Human Kinases Annotated library

• Kinases are enzymatic proteins that phosphorylate other functional proteins

• Physiologically the kinase enzymatic activity can be modulated by
- Catalytic ATP site binders
- Allosteric binders that cause conformational changes within the catalytic ATP site

• Kinases are well recognized as important therapeutic targets for
- Oncology, e.g. cancer immunotherapy
- Inflammatory diseases, e.g. fibrosis, rheumatoid arthritis
- Cardiovascular system, e.g. cerebral vasospasm, pulmonary arterial hypertension