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ChemDiv in Publications and Patents

Revolutionizing GPCR–ligand predictions: DeepGPCR with experimental validation for high-precision drug discovery

Haiping Zhang; Hongjie Fan; Jixia Wang; Tao Hou; Konda Mani Saravanan; Wei Xia; Hei Wun Kan; Junxin Li; John Z H Zhang; Xinmiao Liang; Yang Chen

Original document: PMC | Score: 8.431637 | Text size: 73184 | Find: similar documents

We performed virtual screening against the ChemDiv database using the DeepGPCR_BC, DeepGPCR_RG and Schrödinger docking with Q9HC97 (GPR35) and GLP_1R serving as representative examples. ... The Chemdiv database, provided by ChemDiv company (https://www.chemdiv.com/), contains approximately 1 500 000 compounds, most of which are purchasable from ChemDiv Company. ... The ChemDiv database was screened using the DeepGPCR_BC, DeepGPCR_RG and Schrödinger docking. ... Chemdiv ID ... Chemdiv ID

Carbenoid-involved reactions integrated with scaffold-based screening generates a Nav1.7 inhibitor

Jirong Shu; Yuwei Wang; Weijie Guo; Tao Liu; Song Cai; Taoda Shi; Wenhao Hu

PMC ID: PMC11169417 | DOI: 10.1038/s42004-024-01213-3 | Journal: Communications Chemistry, 7(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-06-12

Original document: PMC | Score: 8.117959 | Text size: 60496 | Find: similar documents

The chemical space of the OREAL library was compared with 3 different commercial compound libraries, compounds with sodium channel inhibitory activity included in ChEMBL49–51, AN4500 Ion Channel library from ASINEX and Voltage-Gated Ion Channel-Targeted Library from ChemDiv(www.chemdiv.com), by using Principal Moment of Inertia (PMI)52 analysis and Principal Component Analysis (PCA)53,54 To explore the characteristics of shapes of virtual compounds, a PMI analysis was taken to visualize the 3D shape diversity of our OREAL. ... A Principal Moment of Inertia (PMI) analysis of four libraries: OREAL (Blue), ChEMBL (Red), ChemDiv (yellow) and ASINEX (green).

Development of scoring-assisted generative exploration (SAGE) and its application to dual inhibitor design for acetylcholinesterase and monoamine oxidase B

Hocheol Lim

PMC ID: PMC11127438 | DOI: 10.1186/s13321-024-00845-w | Journal: Journal of Cheminformatics, 16(1) | Publisher: Springer International Publishing | Publication date: 2024-05-24

Original document: PMC | Score: 6.12045 | Text size: 83907 | Find: similar documents

Two groups of synthetic compounds were obtained from the ZINC Clean Leads [15, 16], and 11 commercially available vendors (BIONET, Chembridge, ChemDiv, Enamine, IBS, LifeChemical, Maybridge, MolPort, Specs, TargetMol, and VitasM).

Computer-aided pattern scoring – A multitarget dataset-driven workflow to predict ligands of orphan targets

Katja Stefan; Vigneshwaran Namasivayam; Sven Marcel Stefan

PMC ID: PMC11116543 | DOI: 10.1038/s41597-024-03343-8 | Journal: Scientific Data, 11(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-05-23

Original document: PMC | Score: 6.3167486 | Text size: 63189 | Find: similar documents

Many vendors are available providing different(ly focused) virtual compound libraries [e.g., ChemDiv (https://www.chemdiv.com), ChemSpace (https://chem-space.com), Enamine (https://enamine.net), MolPort (https://www.molport.com), ZINC (https://zinc20.docking.org), etc];

High-throughput screening identifies broad-spectrum Coronavirus entry inhibitors

Suman Khan; Efrat Ozer Partuk; Jeanne Chiaravalli; Noga Kozer; Khriesto A. Shurrush; Yael Elbaz-Alon; Nadav Scher; Emilie Giraud; Jaouen Tran-Rajau; Fabrice Agou; Haim Michael Barr; Ori Avinoam

PMC ID: PMC11176637 | DOI: 10.1016/j.isci.2024.110019 | Journal: iScience, 27(1) | Publisher: Elsevier | Publication date: 2024-05-17

Original document: PMC | Score: 7.3305492 | Text size: 78673 | Find: similar documents

ChemDiv ... The composition of the screening set was 0.7% Bioactive Screening Libraries (Selleck Chemicals, USA), 7.6% HitFinder Collection (Maybridge, USA), 10.8% Drug-Like Set (Enamine, Ukraine), 26.8% DIVERset-CL (Chembridge, USA), 54.1% Diversity Library (ChemDiv, USA).

Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16

Kejue Wu; Yinfeng Guo; Tiefeng Xu; Weifeng Huang; Deyin Guo; Liu Cao; Jinping Lei; Shijun Zhong

PMC ID: PMC11124212 | DOI: 10.3390/molecules29102312 | Journal: Molecules, 29(1) | Publisher: MDPI | Publication date: 2024-05-15

Original document: PMC | Score: 8.134724 | Text size: 53352 | Find: similar documents

A total of 349,000 compounds from the ZINC15 database and 100,000 compounds from the ChemDiv database were collected and screened by filtering steps of the virtual screening workflow (HTVS, SP, XP) of Schrödinger software. ... Additionally, we selected an extra dataset of 100,000 molecules from ChemDiv ( ... https://www.chemdiv.com/catalog/diversity-libraries ... The virtual screening workflow (HTVS, SP, XP) in Schrödinger software combined with visual inspection of the binding interactions were used for our screening of 349,000 compounds from the ZINC database and 100,000 compounds from the ChemDiv database.

Discovering allatostatin type-C receptor specific agonists

Kübra Kahveci; Mustafa Barbaros Düzgün; Abdullah Emre Atis; Abdullah Yılmaz; Aida Shahraki; Basak Coskun; Serdar Durdagi; Necla Birgul Iyison

PMC ID: PMC11087482 | DOI: 10.1038/s41467-024-48156-w | Journal: Nature Communications, 15(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-05-10

Original document: PMC | Score: 7.8062797 | Text size: 74446 | Find: similar documents

ChemDiv GPCR-Targeted (64515 compounds) and Peptidomimetic (61518 compounds) libraries were used in virtual screening, targeting the orthosteric pocket of the AlstR-C. ... Peptidomimetic70 and GPCR-Targeted71 libraries from ChemDiv were prepared with LigPrep module of Maestro molecular modeling package using OPLS3e72 force field. ... All the finally selected compounds with at least 95% purity were ordered from ChemDiv (https://www.chemdiv.com/).

An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors

Tony Eight Lin; Dyan Yen; Wei‐Chun HuangFu; Yi‐Wen Wu; Jui‐Yi Hsu; Shih‐Chung Yen; Tzu‐Ying Sung; Jui‐Hua Hsieh; Shiow‐Lin Pan; Chia‐Ron Yang; Wei‐Jan Huang; Kai‐Cheng Hsu

Original document: PMC | Score: 6.440691 | Text size: 52408 | Find: similar documents

The screening library (1.6 million compounds) was obtained from ChemDiv (https://www.chemdiv.com).

Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease

Alexandra M. D’Ordine; Gerwald Jogl; John M. Sedivy

PMC ID: PMC11078990 | DOI: 10.1038/s41467-024-48066-x | Journal: Nature Communications, 15(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-05-08

Original document: PMC | Score: 8.151964 | Text size: 83546 | Find: similar documents

The following EN inhibitors were obtained from the listed suppliers through Molport: AD2/ZINC89469886/NSC89640 (Alinda IBS-L0127235), AD3/ZINC100299612 (ChemBridge 5151622), AD5/ZINC100499350 (ChemDiv 1440-2881), AD7/ZINC254379081 (Enamine Z56821059), AD9/ZINC20677610 (ChemDiv K784-1448),

Recent Advances in the Discovery of SIRT1/2 Inhibitors via Computational Methods: A Perspective

Naomi Scarano; Chiara Brullo; Francesca Musumeci; Enrico Millo; Santina Bruzzone; Silvia Schenone; Elena Cichero; George Mihai Nitulescu; Dragos Mihai

PMC ID: PMC11123952 | DOI: 10.3390/ph17050601 | Journal: Pharmaceuticals, 17(1) | Publisher: MDPI | Publication date: 2024-05-08

Original document: PMC | Score: 7.5663624 | Text size: 136419 | Find: similar documents

In particular, the ROC-AUC associated with preliminary screening and an annotated database was reported, and the best performing conformation (PDB ID: 5Y5N) [20] was chosen to perform a VS of a CNS-focused library from ChemDIV (22,000 compounds). ... The selected computational protocol was applied for the search of putative SIRT2Is based on the ChemDIV library (22, 000 compounds), thereby leading to L407-0319 as a modest inhibitor (see previous Table 5, Entry 6). ... ChemDIV (22,000)

Small-Molecule Inhibitors of TIPE3 Protein Identified through Deep Learning Suppress Cancer Cell Growth In Vitro

Xiaodie Chen; Zhen Lu; Jin Xiao; Wei Xia; Yi Pan; Houjun Xia; Youhai H. Chen; Haiping Zhang; Alexander E. Kalyuzhny; David Qian

PMC ID: PMC11082981 | DOI: 10.3390/cells13090771 | Journal: Cells, 13(1) | Publisher: MDPI | Publication date: 2024-04-30

Original document: PMC | Score: 6.2764883 | Text size: 60410 | Find: similar documents

Our screening encompassed the ZINC database (version 2019), and this methodology could be applied to subsequent versions of ZINC or other popular databases like ChemDiv or the Natural Product Database.

Illuminating Dark Chemical Matter Using the Cell Painting Assay

Axel Pahl; Jie Liu; Sohan Patil; Soheila Rezaei Adariani; Beate Schölermann; Jens Warmers; Jana Bonowski; Sandra Koska; Yasemin Akbulut; Carina Seitz; Sonja Sievers; Slava Ziegler; Herbert Waldmann

Original document: PMC | Score: 8.441963 | Text size: 61732 | Find: similar documents

ChemDiv offers a DCM library17 that represents the overlap of the 140,000 DCM compounds published by Wassermann et al. and the ChemDiv compound stock. ... The structural overlap of the full ChemDiv data set with our internal compound database (“COMAS DB”, 194,832 compounds) was determined by InChIKey to be 2818 compounds (Figure 1A). ... The full ChemDiv DCM data set was filtered for compounds with sufficient availability (“available” ≥ 2 mg), leaving 18,411 compounds. ... The PAINS filter by Saubern et al. was used to detect problematic moieties.44 All tested compounds were obtained from commercial sources, mostly from ChemDiv.

Data-balanced transformer for accelerated ionizable lipid nanoparticles screening in mRNA delivery

Kun Wu; Xiulong Yang; Zixu Wang; Na Li; Jialu Zhang; Lizhuang Liu

Original document: PMC | Score: 6.440691 | Text size: 61365 | Find: similar documents

Firstly, the pre-training dataset is derived from previous work [44], consisting of 19 datasets.(The 19 datasets include Targetmol (link), Chemdiv (link), Enamine (link), Chembridge (link), Life Chemical (link), Specs (link), Vitas-M (link), InterBioScreen (link), Maybridge (link), Bionet-Key Organics (link), Asinex (link), UkrOrgSynthesis (link), Eximed (link), HTS Biochemie Innovationen (link), Princeton BioMolecular (link), Otava (link), Alinda Chemical (link), Analyticon (link), ZINC (link) and ChemBL (link).) The dataset comprises 19 million molecules, with each molecule randomly generating 11 conformations, resulting in a total of 209 million conformations.

Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Stephane Ferretti; Jacques Hamon; Ruben de Kanter; Clemens Scheufler; Rita Andraos-Rey; Stephanie Barbe; Elisabeth Bechter; Jutta Blank; Vincent Bordas; Ernesta Dammassa; Andrea Decker; Noemi Di Nanni; Marion Dourdoigne; Elena Gavioli; Marc Hattenberger; Alisa Heuser; Christelle Hemmerlin; Jürgen Hinrichs; Grainne Kerr; Laurent Laborde; Isabel Jaco; Eloísa Jiménez Núñez; Hans-Joerg Martus; Cornelia Quadt; Markus Reschke; Vincent Romanet; Fanny Schaeffer; Joseph Schoepfer; Maxime Schrapp; Ross Strang; Hans Voshol; Markus Wartmann; Sarah Welly; Frédéric Zécri; Francesco Hofmann; Henrik Möbitz; Marta Cortés-Cros

Original document: PMC | Score: 5.762312 | Text size: 95858 | Find: similar documents

Compound 1 (ZINC21803075, D475-1631) was purchased from ChemDiv, and the synthesis of compounds 2–6 is described in the Supplementary Information.

The Dual-Targeted Fusion Inhibitor Clofazimine Binds to the S2 Segment of the SARS-CoV-2 Spike Protein

Matthew R. Freidel; Pratiti A. Vakhariya; Shalinder K. Sardarni; Roger S. Armen; Chaoping Chen; Andreas Jekle

PMC ID: PMC11054727 | DOI: 10.3390/v16040640 | Journal: Viruses, 16(1) | Publisher: MDPI | Publication date: 2024-04-20

Original document: PMC | Score: 6.197487 | Text size: 72058 | Find: similar documents

Samples of Arbidol 1 and derivatives were purchased from ChemDiv, including 1 (1635-0087), 1b (8015-5742) and 1c (H027-0218C) and 1d (H027-0205C).

Identification of novel small molecule inhibitors of twin arginine translocation (Tat) pathway and their effect on the control of Campylobacter jejuni in chickens

Loïc Deblais; Mary Drozd; Anand Kumar; Janet Antwi; James Fuchs; Rahul Khupse; Yosra A. Helmy; Gireesh Rajashekara

PMC ID: PMC11061419 | DOI: 10.3389/fmicb.2024.1342573 | Journal: Frontiers in Microbiology, 15(1) | Publisher: Frontiers Media S.A. | Publication date: 2024-04-17

Original document: PMC | Score: 6.0453043 | Text size: 83854 | Find: similar documents

However, known bioactive collection (Biomol 4, MSDiscovery 1, Microsource 1, and MIH Clinical Collection 1 and 2) displayed higher hit rate (approximately 3.54%) than commercial libraries (Asinex, Chembridge 3, Chemdiv 4, Enamine 2, Lifechemicals 1, and Maybridge 5; approximately 1.20%), suggesting that each library might be composed of SM with distinct chemical structures (Supplementary Table S2).

Bioinformatics-driven discovery of novel EGFR kinase inhibitors as anti-cancer therapeutics: In silico screening and in vitro evaluation

Awwad A. Radwan; Fars Alanazi; Abdullah Al-Dhfyan; Wagdy Mohamed Eldehna

PMC ID: PMC11020408 | DOI: 10.1371/journal.pone.0298326 | Journal: PLOS ONE, 19(1) | Publisher: Public Library of Science | Publication date: 2024-04-16

Original document: PMC | Score: 8.431431 | Text size: 42199 | Find: similar documents

In our study we used the ChemDiv diversity database for receptor-based virtual screening to secure EGFR-TK inhibitors chemotherapeutics. ... In our study, we applied the VS study using EGFR-TK receptor-gefitinib complex structure against a diversity set of 350,000 small-molecule compounds (ChemDiv Library DC0, accessed Sep 08, 2022) in order to identify new EGFR inhibitors as potential anti-cancer agents. ... The structures of the screening library of 350,000 compounds were obtained from the ChemDiv (https://www.chemdiv.com/) (accessed on 1-Jan-2022) online collection using the publicly available discovery chemistry (DC01).

Discovery of Strong 3-Nitro-2-Phenyl-2H-Chromene Analogues as Antitrypanosomal Agents and Inhibitors of Trypanosoma cruzi Glucokinase

Shane M. Carey; Destiny M. O’Neill; Garrett B. Conner; Julian Sherman; Ana Rodriguez; Edward L. D’Antonio; Bernhard Biersack

PMC ID: PMC11050443 | DOI: 10.3390/ijms25084319 | Journal: International Journal of Molecular Sciences, 25(1) | Publisher: MDPI | Publication date: 2024-04-13

Original document: PMC | Score: 6.3167486 | Text size: 57713 | Find: similar documents

For the 3-nitro-2-phenyl-2H-chromene analogues, compounds 1–7 were purchased from TimTec, LLC (Tampa, FL, USA), while compounds 8–13 were purchased from ChemDiv, Inc.

Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1

Yanling He; Xinyuan Zhang; Weijun Pan; Jiebiao Zhang; Weiliang Zhu; Jian Zhang; Jian Shi

PMC ID: PMC11077371 | DOI: 10.7150/ijbs.87442 | Journal: International Journal of Biological Sciences, 20(1) pp. 2403-2421 | Publisher: Ivyspring International Publisher | Publication date: 2024-04-08

Original document: PMC | Score: 6.0453043 | Text size: 65419 | Find: similar documents

Based on Chemdiv library, we screened the compounds which have high affinity to CILK1 and relatively low affinity to CDK1 protein, by virtual screening and molecular docking.

The gasdermin family: emerging therapeutic targets in diseases

Chenglong Zhu; Sheng Xu; Ruoyu Jiang; Yizhi Yu; Jinjun Bian; Zui Zou

Original document: PMC | Score: 4.853503 | Text size: 262585 | Find: similar documents

A virtual screen of ChemDiv compounds conducted by Cao et al. revealed that C202-2729 potently inhibits inflammation, manifesting robust anti-inflammatory activity in mouse models of endotoxin shock and EAE.503 C202-2729 does not affect either the cleavage of GSDMD or the initiation of inflammasome activation upstream.

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

Frances M. Bashore; Vittorio L. Katis; Yuhong Du; Arunima Sikdar; Dongxue Wang; William J. Bradshaw; Karolina A. Rygiel; Tina M. Leisner; Rod Chalk; Swati Mishra; C. Andrew Williams; Opher Gileadi; Paul E. Brennan; Jesse C. Wiley; Jake Gockley; Gregory A. Cary; Gregory W. Carter; Jessica E. Young; Kenneth H. Pearce; Haian Fu; Alison D. Axtman; Yanlin Yu

PMC ID: PMC10868801 | DOI: 10.1371/journal.pone.0293548 | Journal: PLOS ONE, 19(1) | Publisher: Public Library of Science | Publication date: 2024-02-15

Original document: PMC | Score: 7.276384 | Text size: 75386 | Find: similar documents

A total of 138,214 compounds from two chemical diversity libraries (ChemDiv and Asinex) at Emory Chemical Biology Discovery Center (ECBDC) have been screened. ... Compounds 2–41 were purchased from ChemDiv, ChemBridge, Vitascreen, LifeChemicals, and Enamine.

Targeting MYC at the intersection between cancer metabolism and oncoimmunology

Simran Venkatraman; Brinda Balasubramanian; Chanitra Thuwajit; Jaroslaw Meller; Rutaiwan Tohtong; Somchai Chutipongtanate

PMC ID: PMC10881682 | DOI: 10.3389/fimmu.2024.1324045 | Journal: Frontiers in Immunology, 15(1) | Publisher: Frontiers Media S.A. | Publication date: 2024-02-08

Original document: PMC | Score: 6.197487 | Text size: 79361 | Find: similar documents

The novel inhibitor was identified using the drug database ChemDiv and molecularly docked to the crystallized structure of the MYC-MAX heterodimer complexed with DNA (PDB ID: 1NKP) (176).

Screening Techniques for Drug Discovery in Alzheimer’s Disease

Sandra Maniam; Subashani Maniam

PMC ID: PMC10870277 | DOI: 10.1021/acsomega.3c07046 | Journal: ACS Omega, 9(1) pp. 6059-6073 | Publisher: American Chemical Society | Publication date: 2024-02-05

Original document: PMC | Score: 5.971982 | Text size: 84447 | Find: similar documents

Virtual screening through ROCS was used to identify inhibitors of BChE (Figure 9a).65 Biochemical evaluations were conducted on Chemdiv database which contains over a million compounds.

Identification of New EGFR Inhibitors by Structure-Based Virtual Screening and Biological Evaluation

Shuyi Wang; Xiaotian Xu; Chuxin Pan; Qian Guo; Qinlan Li; Shanhe Wan; Zhonghuang Li; Jiajie Zhang; Xiaoyun Wu; Elena Levantini

PMC ID: PMC10856253 | DOI: 10.3390/ijms25031887 | Journal: International Journal of Molecular Sciences, 25(1) | Publisher: MDPI | Publication date: 2024-02-04

Original document: PMC | Score: 8.419415 | Text size: 43566 | Find: similar documents

To identify potential inhibitors, molecular docking-based virtual screening was conducted on ChemDiv and Enamine commercial databases using the Glide program. ... Molecular docking was conducted on ChemDiv and Enamine commercial databases. ... Two databases, Chemdiv and Enamine, were rationally selected according to the structural diversity and commercial availability of the compounds. ... First, ChemDiv and Enamine databases were downloaded from the ZINC website [18,19], prepared using the Ligprep module, and filtered using Lipinski’s rule of five to improve compound drug-likeness [20]. ... Commercially available compounds of the ChemDiv (about 1,400,000 compounds) and Enamine (about 1,800,000 compounds) databases were downloaded from the ZINC website.

Molecular fragmentation as a crucial step in the AI-based drug development pathway

Shao Jinsong; Jia Qifeng; Chen Xing; Yajie Hao; Li Wang

PMC ID: PMC10834946 | DOI: 10.1038/s42004-024-01109-2 | Journal: Communications Chemistry, 7(1) | Publisher: Nature Publishing Group UK | Publication date: 2024-02-01

Original document: PMC | Score: 6.3988395 | Text size: 50714 | Find: similar documents

ChemDiv

TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer

Filipa Lynce; Laura E. Stevens; Zheqi Li; Jane E. Brock; Anushree Gulvady; Ying Huang; Faina Nakhlis; Ashka Patel; Jeremy M. Force; Tufia C. Haddad; Naoto Ueno; Vered Stearns; Antonio C. Wolff; Amy S. Clark; Jennifer R. Bellon; Edward T. Richardson; Justin M. Balko; Ian E. Krop; Eric P. Winer; Paulina Lange; E. Shelley Hwang; Tari A. King; Sara M. Tolaney; Alastair Thompson; Gaorav P. Gupta; Elizabeth A. Mittendorf; Meredith M. Regan; Beth Overmoyer; Kornelia Polyak

Original document: PMC | Score: 7.3305492 | Text size: 59286 | Find: similar documents

N.U. is a consultant for AstraZeneca plc, Bayer AG, Pfizer Inc., Gilead Sciences, Inc., Chugai Pharmaceutical Co., CytoDyn Inc., Daiichi Sankyo, Inc., DynaMed, LLC, Eisai Co., Ltd., KeChow Pharma, Inc., Lavender Health Ltd., OBI Pharma Inc., OncoCyte Co., Ourotech, Inc., DBA Pear Bio, Kirilys Therapeutics, Inc., Peptilogics, Inc., Phoenix Molecular Designs, Preferred Medicine, Inc., Puma Biotechnology, Inc., Sumitomo Dainippon Pharma, Inc., Sysmex Co. Ltd., Takeda Pharmaceuticals, Ltd., Unitech Medical, Inc., CARNA Biosciences, Inc., ChemDiv, Inc., DualityBio, LARVOL, Oncolys BioPharma Inc., Rakuten Medical, Inc., Merck Co.

Identification of Triazolopyrimidinyl Scaffold SARS-CoV-2 Papain-Like Protease (PLpro) Inhibitor

Sebastjan Kralj; Marko Jukič; Miha Bahun; Luka Kranjc; Anja Kolarič; Milan Hodošček; Nataša Poklar Ulrih; Urban Bren; Bingfang Yan

PMC ID: PMC10893172 | DOI: 10.3390/pharmaceutics16020169 | Journal: Pharmaceutics, 16(1) | Publisher: MDPI | Publication date: 2024-01-25

Original document: PMC | Score: 6.4830923 | Text size: 44717 | Find: similar documents

We collected commercially available libraries marketed as protease inhibitor libraries (APExBIO (Houston, TX, USA), Asinex (Winston-Salem, NC, USA), ChemDiv (San Diego, CA, USA), Enamine (Cincinnati, OH, USA), Life Chemicals (Kyiv, Ukraine), Otava (Ann Arbor, MI, USA), Selleckchem (Houston, TX, USA), TargetMol (Boston, MA, USA)) and expanded the database with all cysteine protease inhibitors and all viral proteases available in the ChEMBL dataset using SQLite.

Identification of CK2α’ selective inhibitors by the screening of an allosteric-kinase-inhibitor-like compound library

Deepti Mudaliar; Rachel H. Mansky; Angel White; Grace Baudhuin; Jon Hawkinson; Henry Wong; Michael A. Walters; Rocio Gomez-Pastor

PMC ID: PMC10849513 | DOI: 10.1101/2024.01.18.576328 | Journal: bioRxiv | Publisher: Cold Spring Harbor Laboratory | Publication date: 2024-01-22

Original document: PMC | Score: 8.504611 | Text size: 61533 | Find: similar documents

With this promising potential binding pocket as our target, we performed a screen of a commercial library of ~29,000 allosteric kinase inhibitor-like compounds (The ChemDiv Allosteric Kinase Inhibitor (CDAKI) Library) using a CK2α’ activity-dependent ADP-GloTM Kinase assay. ... To identify new CK2α’ hits that could potentially target this Type IV allosteric site, we decided to screen a commercial library of 28,812 allosteric-kinase-inhibitor-like compounds (The ChemDiv Allosteric Kinase Inhibitor (CDAKI) Library). ... The optimized ADP GloTM standard HTS assay was used to screen 28,812 compounds of the ChemDiv Allosteric Kinase Inhibitor (CDAKI) Library (ChemDiv, Inc) (Fig. 3).

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

Si Min Zhang; Cynthia B.J. Paulin; Huazhang Shu; Miriam Yagüe-Capilla; Maurice Michel; Petra Marttila; Florian Ortis; Henri Colyn Bwanika; Christopher Dirks; Rajagopal Papagudi Venkatram; Elisée Wiita; Ann-Sofie Jemth; Ingrid Almlöf; Olga Loseva; Femke M. Hormann; Tobias Koolmeister; Erika Linde; Sun Lee; Sabin Llona-Minguez; Martin Haraldsson; Hanna Axelsson; Kia Strömberg; Evert J. Homan; Martin Scobie; Thomas Lundbäck; Thomas Helleday; Sean G. Rudd

PMC ID: PMC10839966 | DOI: 10.1016/j.isci.2024.108907 | Journal: iScience, 27(1) | Publisher: Elsevier | Publication date: 2024-01-13

Original document: PMC | Score: 5.971982 | Text size: 103523 | Find: similar documents

We initiated this study with one of the largest reported biochemical screening campaigns against SAMHD1, composed of 17,656 diverse chemical entities of both commercial (Enamine, TimTec, Maybridge, and ChemDiv) and/or in-house origins (donation from Biovitrum).

Identification of human phosphoglycerate mutase 1 (PGAM1) inhibitors using hybrid virtual screening approaches

Numan Yousaf; Rima D Alharthy; Maryam; Iqra Kamal; Muhammad Saleem; Muhammad Muddassar

Original document: Medline | Score: 10.21365 | Text size: 2227 | Find: similar documents

The best query model was then employed for performing shape, color, and electrostatics complementarity-based virtual screening of the ChemDiv database.

Identification of a novel small-molecule inhibitor targeting TIM-3 for cancer immunotherapy

Menghan Wu; Aijun Wu; Xiangrui Zhang; Yang Li; Beibei Li; Shengzhe Jin; Qingyu Dong; Xiaoshuang Niu; Lihan Zhang; Xiaowen Zhou; Jiangfeng Du; Yahong Wu; Wenjie Zhai; Xiuman Zhou; Lu Qiu; Yanfeng Gao; Wenshan Zhao

Original document: Medline | Score: 12.223339 | Text size: 1396 | Find: similar documents

Here, to identify small molecule inhibitors targeting TIM-3, the docking pocket in TIM-3 was analyzed by Molecular Operating Environment (MOE) and the Chemdiv compound database was screened.

Exploring allosteric hits of the NS2B-NS3 protease of DENV2 by structure-guided screening

Aditi Gangopadhyay; Achintya Saha

Original document: Medline | Score: 10.21365 | Text size: 2227 | Find: similar documents

This study aimed to identify serotype-specific hits against the allosteric site in the NS2B-NS3 protease of DENV serotype 2 (DENV2) from the Enamine, Selleck, and ChemDiv antiviral libraries.

Machine learning- and structure-based discovery of a novel chemotype as FXR agonists for potential treatment of nonalcoholic fatty liver disease

Tong Qin; Xuefeng Gao; Lei Lei; Jing Feng; Wenxuan Zhang; Yuhua Hu; Zhufang Shen; Zhenming Liu; Yi Huan; Song Wu; Jie Xia; Liangren Zhang

DOI: 10.1016/j.ejmech.2023.115307 | ISSN: 1768-3254 | Journal: European journal of medicinal chemistry, 252 pp. 115307-115307 | Publisher: Editions Scientifiques Elsevier | Publication date: 2023-03-27 | Print publication date: 2023-04-05

Original document: Medline | Score: 14.456684 | Text size: 2581 | Find: similar documents

To this end, we developed a multi-stage computational workflow to screen the Specs and ChemDiv chemical library for FXR agonists, which consisted of machine learning (ML)-based classifiers, shape-based and electrostatic-based models, a FRED-based molecular docking protocol, an ADMET prediction protocol and substructure search. ... As a result, we identified a novel chemotype that has never been reported before, with compound XJ02862 (ChemDiv ID: Y020-6413) as the representative.

Virtual Screening and In Vitro Experimental Verification of LuxS Inhibitors for Escherichia coli O157:H7

Yu-Bin Bai; Xiao-Rong Yang; Bing Li; Xu-Zheng Zhou; Wei-Wei Wang; Fu-Sheng Cheng; Ji-Yu Zhang

Original document: Medline | Score: 8.771491 | Text size: 2730 | Find: similar documents

High-affinity inhibitors were screened from the ChemDiv database (1,535,478 compounds) using LuxS as a ligand.

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches

Leah Amod; Roxanne Mohunlal; Nicole Teixeira; Timothy J Egan; Kathryn J Wicht

Original document: Medline | Score: 13.557122 | Text size: 1349 | Find: similar documents

Identifying Dopamine D3 Receptor Ligands through Virtual Screening and Exploring the Binding Modes of Hit Compounds

Hongshan Jin; Chengjun Wu; Rui Su; Tiemin Sun; Xingzhou Li; Chun Guo

Original document: Medline | Score: 9.682976 | Text size: 2444 | Find: similar documents

All molecules in the ChemDiv library (>1,500,000) were narrowed down to a final set of 37 molecules for the binding assays.

Ligand-Based Drug Design of Novel Antimicrobials against Staphylococcus aureus by Targeting Bacterial Transcription

Jiqing Ye; Xiao Yang; Cong Ma

Original document: Medline | Score: 10.8058605 | Text size: 2040 | Find: similar documents

The ligand-based models-including the pharmacophore model, 3D QSAR, AutoQSAR, and ADME/T calculation-were integrated and used in the following virtual screening of the ChemDiv PPI database.

Inhibiting the growth of ovarian cancer cells in vitro and in vivo by a small molecular inhibitor targeting La-RNA interactions

Yueyan Li; Xuan Huang; Jing Tang

Original document: Medline | Score: 9.682976 | Text size: 2238 | Find: similar documents

A docking virtual assay on the Chemdiv database was used to screen La binders, and their affinity were measured by surface plasmon resonance (SPR).

Molecular docking and dynamics guided approach to identify potential anti-inflammatory molecules as NRF2 activator to protect against drug-induced liver injury (DILI): a computational study

Ajay Mili; Subham Das; Krishnadas Nandakumar; Richard Lobo

Original document: Medline | Score: 10.8058605 | Text size: 2007 | Find: similar documents

Acquiring and preparing the KEAP1-NRF2 Protein (PDB: 4L7D) with Schrodinger Suite was followed by developing a ligand library (Anti-inflammatory library downloaded from ChemDiv database).

Computational investigation of peptidomimetics as potential inhibitors of SARS-CoV-2 spike protein

Mayar Tarek Ibrahim; Peng Tao

Original document: Medline | Score: 15.672428 | Text size: 1864 | Find: similar documents

Virtual screening of two different peptidomimetics databases, ChEMBL and ChemDiv databases, was carried out against both S1 and S2 subunits. ... Multi-layered filtration, based on physicochemical properties and docking scores, of nearly 114,000 compounds found in the ChEMBL database and nearly 14,000 compounds in the ChemDiv database was employed.

Prediction of novel and potent inhibitors of lanosterol 14-α demethylase

Mohd Waseem; Jitendra K Thakur; Naidu Subbarao

Original document: Medline | Score: 11.470976 | Text size: 1619 | Find: similar documents

In this study, we have screened a large number of small molecules from different chemical databases (ZINC, DrugBank, ChEMBL, and ChemDiv) to find out novel and potential inhibitors of LDM.

Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity

Tanaporn Uengwetwanit; Nopporn Chutiwitoonchai; Kanin Wichapong; Nitsara Karoonuthaisiri

Original document: Medline | Score: 12.223339 | Text size: 1549 | Find: similar documents

Molecular docking was employed to screen inhibitors of SARS-CoV-2 from the ZINC ChemDiv database.

In silico high-throughput screening system for AKT1 activators with therapeutic applications in sepsis acute lung injury

Ziyi Wang; Xuesong Wang; Zhe Guo; Haiyan Liao; Yan Chai; Ziwen Wang; Zhong Wang

Original document: Medline | Score: 13.9169035 | Text size: 2549 | Find: similar documents

The current study was aim to construct a high-throughput screening (HTS) system based on the ChemDiv database (https://www.chemdiv.com/complete-list/) and use the system to screen for AKT1 activation agents, which may provide clues for the research and development of new drugs to treat SALI. ... Based on the existing X-ray structure of AKT1 and known AKT activators, a large-scale virtual HTS was performed on the ChemDiv database of small molecules by the cascade docking method and demonstrated both accuracy and screening efficiency.

Structure-based pharmacophore modeling, virtual screening, and molecular dynamics simulation studies for identification of Plasmodium falciparum 5-aminolevulinate synthase inhibitors

Gbolahan O Oduselu; Rufus Afolabi; Ibitayo Ademuwagun; Ashley Vaughan; Ezekiel Adebiyi

Original document: Medline | Score: 10.8058605 | Text size: 2191 | Find: similar documents

Identification of Potent and Selective JAK1 Lead Compounds Through Ligand-Based Drug Design Approaches

Sathya Babu; Santhosh Kumar Nagarajan; Sruthy Sathish; Vir Singh Negi; Honglae Sohn; Thirumurthy Madhavan

Original document: Medline | Score: 9.204724 | Text size: 2774 | Find: similar documents

Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening

Danfeng Shi; Qianqian Pang; Qianyu Qin; Xinsheng Yao; Xiaojun Yao; Yang Yu

Original document: Medline | Score: 10.8058605 | Text size: 1952 | Find: similar documents

Virtual screening based on the structure of more than 105 compounds against four key proteins of SARS-CoV-2: MPro, SRBD, RdRp, and PLpro

Farzan Nabati; Ayshin Kamyabiamineh; Ramin Kosari; Faezeh Ghasemi; Seyedehmasoumeh Seyedebrahimi; Sobhan Mohammadi; Mohammad Moradi

Original document: Medline | Score: 10.8058605 | Text size: 1947 | Find: similar documents

We performed structure-based virtual screening (SBVS) of a library that was built from ChemDiv and PubChem databases against four SARS-CoV-2 target proteins: S-protein (spike), main protease (MPro), RNA-dependent RNA polymerase, and PLpro.

In silico identification and in vitro antiviral validation of potential inhibitors against Chikungunya virus

Jyoti Verma; Abdul Hasan; Sujatha Sunil; Naidu Subbarao

Original document: Medline | Score: 17.851965 | Text size: 2218 | Find: similar documents

Another potential inhibitor with ID ChemDiv 8015-3006 binds at both the target sites and shows anti-CHIKV activity at EC50 = 41 μM. ... The results show dose-dependent inhibitory effects of Taxifolin, Rutin and ChemDiv 8015-3006 against the CHIKV with minimal cytotoxicity. ... In conclusion, our study reports Taxifolin, Rutin and ChemDiv 8015-3006 as potential inhibitors of the CHIKV entry.

Discovery of Chitin Deacetylase Inhibitors through Structure-Based Virtual Screening and Biological Assays

Yaodong Liu; Sibtain Ahmed; Yaowei Fang; Meng Chen; Jia An; Guang Yang; Xiaoyue Hou; Jing Lu; Qinwen Ye; Rongjun Zhu; Qitong Liu; Shu Liu

Original document: Medline | Score: 12.637784 | Text size: 1540 | Find: similar documents

In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening.

MasitinibL shows promise as a drug-like analog of masitinib that elicits comparable SARS-Cov-2 3CLpro inhibition with low kinase preference

Olanrewaju Ayodeji Durojaye; Nkwachukwu Oziamara Okoro; Arome Solomon Odiba; Bennett Chima Nwanguma

PMC ID: PMC10141821 | DOI: 10.1038/s41598-023-33024-2 | Journal: Scientific Reports, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2023-04-28

Original document: PMC | Score: 9.797036 | Text size: 76768 | Find: similar documents

The chemical compound databases screened (based on pharmacophore-matching) include the CHEMBL30, ChemDiv, ChemSpace, Mcule, Mcule-ultimate, MolPort, NCI Open Chemical Repository, WuXi LabNetwork, and the ZINC databases. ... ChemDiv

Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors

Francesca Curreli; Kent Chau; Thanh-Thuy Tran; Isabella Nicolau; Shahad Ahmed; Pujita Das; Christopher D. Hillyer; Mary Premenko-Lanier; Asim K. Debnath; Yinzhong Shen

PMC ID: PMC10141620 | DOI: 10.3390/v15041001 | Journal: Viruses, 15(1) | Publisher: MDPI | Publication date: 2023-04-19

Original document: PMC | Score: 7.26731 | Text size: 59967 | Find: similar documents

We screened a set of twenty-two small molecules, of which NBCoV35-37 were purchased from Chembridge Corporation (San Diego, CA, USA) and NBCoV62-82 were purchased from ChemDiv, Inc.

Exploring potential SARS-CoV-2 Mpro non-covalent inhibitors through docking, pharmacophore profile matching, molecular dynamic simulation, and MM-GBSA

Yunfan Shi; Liting Dong; Zhuang Ju; Qiufu Li; Yanru Cui; Yiran Liu; Jiaoyu He; Xianping Ding

Original document: PMC | Score: 13.953599 | Text size: 38164 | Find: similar documents

ChemDiv ID ... ChemDiv ID ... The database are from TargetMol and the compound files are from ChemDiv.

Identification of human phosphoglycerate mutase 1 (PGAM1) inhibitors using hybrid virtual screening approaches

Numan Yousaf; Rima D. Alharthy; Maryam; Iqra Kamal; Muhammad Saleem; Muhammad Muddassar; Pedro Silva

PMC ID: PMC10084823 | DOI: 10.7717/peerj.14936 | Journal: PeerJ, 11(1) | Publisher: PeerJ Inc. | Publication date: 2023-04-07

Original document: PMC | Score: 15.234975 | Text size: 50044 | Find: similar documents

The best query model was then employed for performing shape, color, and electrostatics complementarity-based virtual screening of the ChemDiv database. ... Chemdiv database was prepared by implementing drug like filter criteria to remove unwanted chemical structures, duplicates and salts. ... Toxicological and pharmacokinetics studies were conducted on virtually screened compounds mined from Chemdiv database by using online tool PreADMETv.2.0 (https://preadmet.bmdrc.kr/adme/) (Lee et al., 2004; Lee et al., 2003). ... After generating optimized query model, the Chemdiv database was screened by matching the query features with its compounds.

VSFlow: an open-source ligand-based virtual screening tool

Sascha Jung; Helge Vatheuer; Paul Czodrowski

PMC ID: PMC10064649 | DOI: 10.1186/s13321-023-00703-1 | Journal: Journal of Cheminformatics, 15(1) | Publisher: Springer International Publishing | Publication date: 2023-03-31

Original document: PMC | Score: 10.434273 | Text size: 24957 | Find: similar documents

The web tool SwissSimilarity allows for the 2D fingerprint and 3D shape screening of common public databases and compound libraries of most commercial vendors such as Enamine or ChemDiv [15, 16].

Computational Approaches Drive Developments in Immune-Oncology Therapies for PD-1/PD-L1 Immune Checkpoint Inhibitors

Patrícia S. Sobral; Vanessa C. C. Luz; João M. G. C. F. Almeida; Paula A. Videira; Florbela Pereira; Jean Christopher Chamcheu; Jean Fotie

PMC ID: PMC10054797 | DOI: 10.3390/ijms24065908 | Journal: International Journal of Molecular Sciences, 24(1) | Publisher: MDPI | Publication date: 2023-03-21

Original document: PMC | Score: 5.9023848 | Text size: 87828 | Find: similar documents

Lyu et al. [85] aimed to identify novel inhibitors by using a structure-based virtual screening approach, retrieving about 500 molecules with a high binding affinity from the Chemdiv-Plus database.

Inhibitors of the Oncogenic PA2G4-MYCN Protein-Protein Interface

Hassina Massudi; Jie-Si Luo; Jessica K. Holien; Satyanarayana Gadde; Sukriti Krishan; Mika Herath; Jessica Koach; Brendan W. Stevenson; Michael A. Gorman; Pooja Venkat; Chelsea Mayoh; Xue-Qun Luo; Michael W. Parker; Belamy B. Cheung; Glenn M. Marshall; Vladimir Spiegelman

PMC ID: PMC10046377 | DOI: 10.3390/cancers15061822 | Journal: Cancers, 15(1) | Publisher: MDPI | Publication date: 2023-03-17

Original document: PMC | Score: 7.26731 | Text size: 60232 | Find: similar documents

All compounds were purchased from Chemdiv (

Novel Insights into RAD52’s Structure, Function, and Druggability for Synthetic Lethality and Innovative Anticancer Therapies

Beatrice Balboni; Francesco Rinaldi; Viola Previtali; Andrea Ciamarone; Stefania Girotto; Andrea Cavalli; John J. Turchi

PMC ID: PMC10046612 | DOI: 10.3390/cancers15061817 | Journal: Cancers, 15(1) | Publisher: MDPI | Publication date: 2023-03-17

Original document: PMC | Score: 8.771591 | Text size: 94741 | Find: similar documents

Virtual screening (docking – PDB: 5JRB ssDNA groove: 47,737 cpds Targeted Diversity Library (TDL) – Chemdiv database, DOCK6.5 software) ... Virtual screening (docking – PDB: 5JRB self-association pocket: 66,608 cpds - Chemdiv database, DOCK6.5 software)

Are we ready to fight the Nipah virus pandemic? An overview of drug targets, current medications, and potential leads

Siyun Yang; Supratik Kar

Original document: PMC | Score: 7.26731 | Text size: 59496 | Find: similar documents

In this study, 8722 chemical entities were collected from Asinex-Antiviral Library, 3700 compounds were collected from Enamine-Antiviral Library, and 67,470 molecules were taken from ChemDiv-Antiviral Library.

Small-Molecule Inhibition of Androgen Receptor Dimerization as a Strategy against Prostate Cancer

Weitao Fu; Hao Yang; Chenxian Hu; Jianing Liao; Zhou Gong; Minkui Zhang; Shuai Yang; Shangxiang Ye; Yixuan Lei; Rong Sheng; Zhiguo Zhang; Xiaojun Yao; Chun Tang; Dan Li; Tingjun Hou

Original document: PMC | Score: 9.110828 | Text size: 35835 | Find: similar documents

Through compound library filtering using Lipinski’s rule-of-five, cascade molecular docking, and structural clustering, a total of 476 structurally diverse compounds were screened out from the ChemDiv database (∼1.6 million compounds) and submitted for AR transcriptional activity assay.

Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis

Zachariah P. Schuurs; John P. McDonald; Laura V. Croft; Derek J. Richard; Roger Woodgate; Neha S. Gandhi

PMC ID: PMC10020695 | DOI: 10.3389/fcimb.2023.1051602 | Journal: Frontiers in Cellular and Infection Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2023-03-03

Original document: PMC | Score: 17.08099 | Text size: 69792 | Find: similar documents

A structure-based virtual screening was performed with the ChemDiv library peptidomimetics of β-turn motifs (ChemDiv, 2019). ... The top 53 compounds were subsequently ordered from ChemDiv to test in vitro. ... The ChemDiv libraries Covalent Generic and Smart Inhibitors (ChemDiv, 2020) was docked to the WT LexA using the CovDock (Toledo Warshaviak et al., 2014; Zhu et al., 2014) workflow in the Schrödinger Maestro suite 2019-4. ... The 80 top scoring compounds were ordered from ChemDiv (San Diego, CA). ... A total of 133 compounds from the two screens were ordered from ChemDiv (San Diego, CA), which consisted of 80 molecules from the covalent screen, and 53 molecules from the β-turn library. ... ChemDiv. ... ChemDiv.

Pharmacophore-Aided Virtual Screening and Molecular Dynamics Simulation Identifies TrkB Agonists for Treatment of CDKL5-Deficiency Disorders

Ibitayo Abigail Ademuwagun; Gbolahan Oladipupo Oduselu; Solomon Oladapo Rotimi; Ezekiel Adebiyi

PMC ID: PMC9989394 | DOI: 10.1177/11779322231158254 | Journal: Bioinformatics and Biology Insights, 17(1) | Publisher: SAGE Publications | Publication date: 2023-03-02

Original document: PMC | Score: 8.495119 | Text size: 43363 | Find: similar documents

The Pharmit web server was configured to include best hits from the following databases: PubChem, MCULE, ZINC database, MolPort, CHEMBL30, ChemDiv, ChemSpace, MCULE-ULTIMATE, NCI Open Chemical Repository, and LabNetwork.13 Specifically, the following features were used as thresholds to filter databases in accordance with Lipinski rule of 5, Veber, Ghose, Egan, and Muegge rules.14-17 These include molecular weight ⩽ 500 g, number of rotable bonds ⩽ 10, logP (octanol-water partition coefficient) value ⩽ 5, topological polar surface area (TPSA) ⩽ 140 Å, hydrogen bonds acceptor ⩽ 10, hydrogen bonds donor ⩽ 5, and number of aromatics ⩽ 2.17

Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro

Sheli R. Radoshitzky; Patrick Iversen; Xianghan Lu; Jing Zou; Suzanne J. F. Kaptein; Kelly S. Stuthman; Sean A. Van Tongeren; Jesse Steffens; Ruoyu Gong; Hoa Truong; Annapurna A. Sapre; Huiling Yang; Xiaodong Xie; Jia Jun Chia; Zhijuan J. Song; Stacey M. Leventhal; Josolyn Chan; Alex Shornikov; Xin Zhang; David Cowfer; Helen Yu; Travis Warren; Tomas Cihlar; Danielle P. Porter; Johan Neyts; Pei-Yong Shi; Jay Wells; John P. Bilello; Joy Y. Feng

PMC ID: PMC9950143 | DOI: 10.1038/s41598-023-29517-9 | Journal: Scientific Reports, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2023-02-23

Original document: PMC | Score: 6.8701305 | Text size: 70342 | Find: similar documents

E864-0360 was purchased from ChemDiv (San Diego, CA).

Identification of Small-Molecule Inhibitors of the Salmonella FraB Deglycase Using a Live-Cell Assay

Anice Sabag-Daigle; Erin F. Boulanger; Pankajavalli Thirugnanasambantham; Jamison D. Law; Alex J. Bogard; Edward J. Behrman; Venkat Gopalan; Brian M. M. Ahmer; Carlos J. Blondel

PMC ID: PMC10100877 | DOI: 10.1128/spectrum.04606-22 | Journal: Microbiology Spectrum, 11(1) | Publisher: American Society for Microbiology | Publication date: 2023-02-21

Original document: PMC | Score: 13.455724 | Text size: 46886 | Find: similar documents

ChemDiv ... ChemDiv ... ChemDiv

Virtual Screening and In Vitro Experimental Verification of LuxS Inhibitors for Escherichia coli O157:H7

Yu-Bin Bai; Xiao-Rong Yang; Bing Li; Xu-Zheng Zhou; Wei-Wei Wang; Fu-Sheng Cheng; Ji-Yu Zhang; Livnat Afriat-Jurnou

PMC ID: PMC10100900 | DOI: 10.1128/spectrum.03502-22 | Journal: Microbiology Spectrum, 11(1) | Publisher: American Society for Microbiology | Publication date: 2023-02-21

Original document: PMC | Score: 15.859128 | Text size: 58848 | Find: similar documents

High-affinity inhibitors were screened from the ChemDiv database (1,535,478 compounds) using LuxS as a ligand. ... The present study screened quorum-sensing inhibitors (QSIs) from the ChemDiv database (1,535,478 compounds). ... A virtual screening was performed using the FRED software, where multiple conformations of each compound from the ChemDiv database (1,535,478 compounds, version 2019; ChemDiv, San Diego, CA) were docked to the LuxS pocket. ... Through the rigid docking strategy, 682 compounds with high affinity were screened from the ChemDiv database. ... The ChemDiv database, a commercially available small-molecule database from Shanghai TopScience Biotechnology Co. with more than 1 million compounds, was used as the screening library.

Phosphomevalonate Kinase Controls β‐Catenin Signaling via the Metabolite 5‐Diphosphomevalonate

Zhiqiang Chen; Xinyi Zhou; Xiaojun Zhou; Yi Tang; Mingzhu Lu; Jianhong Zhao; Chenhui Tian; Mingzhi Wu; Yanliang Liu; Edward V. Prochownik; Fubing Wang; Youjun Li

PMC ID: PMC10131864 | DOI: 10.1002/advs.202204909 | Journal: Advanced Science, 10(1) | Publisher: John Wiley and Sons Inc. | Publication date: 2023-02-21

Original document: PMC | Score: 12.559463 | Text size: 63715 | Find: similar documents

Using a virtual screen, we identified the putative PMVK inhibitor top 5 (PMVKi5) (C24H23ClN2O6,N‐[(E)‐[3‐[(4‐chloro‐3,5‐dimethylphenoxy)methyl]‐4‐methoxyphenyl]methylideneamino]‐3,4,5‐trihydroxybenzamide) from a library of 1.7 million ChemDiv small molecule compounds (Figure 7A). ... The PMVK‐based crystal structure (PDB: 3CH4) was used for computer‐based virtual docking of 1.7 million small molecules from the ChemDiv database. ... Small molecules were downloaded from the ChemDiv database (https://www.chemdiv.com).

Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development

Chia-Ju Hsieh; Sam Giannakoulias; E. James Petersson; Robert H. Mach; Irina Velikyan

PMC ID: PMC9964981 | DOI: 10.3390/ph16020317 | Journal: Pharmaceuticals, 16(1) | Publisher: MDPI | Publication date: 2023-02-18

Original document: PMC | Score: 11.418604 | Text size: 78038 | Find: similar documents

[62,63], WuXi AppTec [64], ChemDiv Inc. ... ChemDiv Compound Libraries ... 1.5 M/ChemDiv

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches

Leah Amod; Roxanne Mohunlal; Nicole Teixeira; Timothy J. Egan; Kathryn J. Wicht

PMC ID: PMC9929333 | DOI: 10.1038/s41598-023-29273-w | Journal: Scientific Reports, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2023-02-14

Original document: PMC | Score: 17.088491 | Text size: 40062 | Find: similar documents

In this study, molecular docking and machine learning techniques, including Bayesian and support vector machine classifiers, were used in sequence to screen the in silico ChemDiv 300k Representative Compounds library for inhibitors of βH with retained activity against P. falciparum. ... The ChemDiv 300k Representative Compounds library was initially filtered for druglikeness using Lipinski’s Rule of Five and OSIRIS DataWarrior’s24 inhouse score. ... Virtual screening of the ChemDiv 300k Representative Compounds library and prioritisation of in-silico hits for purchasing and experimental testing against βH and whole-cell cultures of Pf. ... 40.ChemDiv Inc. http://www.chemdiv.com/. ... (ChemDiv Inc.).

Impact of Laboratory-Adapted Intracellular Trypanosoma cruzi Strains on the Activity Profiles of Compounds with Anti-T. cruzi Activity

Melissa L. Sykes; Emily K. Kennedy; Vicky M. Avery; Katharine Carter

PMC ID: PMC9967867 | DOI: 10.3390/microorganisms11020476 | Journal: Microorganisms, 11(1) | Publisher: MDPI | Publication date: 2023-02-14

Original document: PMC | Score: 6.1931806 | Text size: 80014 | Find: similar documents

Ethyl oxo{[2-(4-phenyl-1-piperazinyl)-2-(3-pyridinyl)ethyl]amino} acetate: 20 mM (E155-0206; Chemdiv, San Diego, CA, USA).

In Silico Discovery of Small Molecule Modulators Targeting the Achilles’ Heel of SARS-CoV-2 Spike Protein

Qing Wang; Fanhao Meng; Yuting Xie; Wei Wang; Yumin Meng; Linjie Li; Tao Liu; Jianxun Qi; Xiaodan Ni; Sanduo Zheng; Jianhui Huang; Niu Huang

Original document: PMC | Score: 6.8701305 | Text size: 64011 | Find: similar documents

Our in-house compound library for virtual screening was constructed from the ChemDiv database (

Sorafenib/2800Z Co-Loaded into Cholesterol and PEG Grafted Polylysine NPs for Liver Cancer Treatment

Chen Zhang; Wu Zhong; Ying Cao; Bohao Liu; Xiaojun Tao; Zhuan Li; Silviya Zustiak

PMC ID: PMC9865580 | DOI: 10.3390/ph16010119 | Journal: Pharmaceuticals, 16(1) | Publisher: MDPI | Publication date: 2023-01-13

Original document: PMC | Score: 7.957362 | Text size: 50224 | Find: similar documents

Sorafenib (BAY 43–9006) was purchased from Selleck Chemicals (Shanghai, China), and 2800Z was purchased from Chemdiv (San Diego, CA, USA).

Opportunities and challenges in application of artificial intelligence in pharmacology

Mandeep Kumar; T. P. Nhung Nguyen; Jasleen Kaur; Thakur Gurjeet Singh; Divya Soni; Randhir Singh; Puneet Kumar

Original document: PMC | Score: 6.5141163 | Text size: 77691 | Find: similar documents

It is built on six datasets collected from the ChEMBL database (EGFR inhibitors); the DNN model also obtained high performance in comparison with the RF method by cross-validation or screening a large compound library (PubChem, ChemDiv database) [87].

Identifying Dopamine D3 Receptor Ligands through Virtual Screening and Exploring the Binding Modes of Hit Compounds

Hongshan Jin; Chengjun Wu; Rui Su; Tiemin Sun; Xingzhou Li; Chun Guo; Dmitri B. Kireev

PMC ID: PMC9862751 | DOI: 10.3390/molecules28020527 | Journal: Molecules, 28(1) | Publisher: MDPI | Publication date: 2023-01-05

Original document: PMC | Score: 15.354868 | Text size: 59245 | Find: similar documents

All molecules in the ChemDiv library (>1,500,000) were narrowed down to a final set of 37 molecules for the binding assays. ... The molecules in the ChemDiv compound database (consisting of 1,535,478 compounds at the time this study was initiated) were analyzed by molecular docking using the AutoDock Vina package in short-searching mode. ... Bioinformatics software, such as AutoDock Vina [10], Schrödinger [25], and Pymol [26] and online resources, such as the National Center for Biotechnology Information [27] and ChemDiv Database ( ... ChemDiv in-stock diverse collection database (downloaded from ... Parametric ChemDiv compounds (recorded in PDBQT files) were docked to the ligand-binding site of D3R with AutoDock Vina using the short docking mode and other conFigureurations described in Section 2.1.3.

Targeting SOST using a small-molecule compound retards breast cancer bone metastasis

Lisha Sun; Yixiao Zhang; Guanglei Chen; Yaoting Ji; Qingtian Ma; Xinbo Qiao; Sijin Wu; Lin Zhou; Jiawen Bu; Xudong Zhu; Xiaoying Zhang; Xiaofan Jiang; Chao Liu; Xinnan Li; Yang Liu; Yongliang Yang; Caigang Liu

PMC ID: PMC9798707 | DOI: 10.1186/s12943-022-01697-4 | Journal: Molecular Cancer, 21(1) | Publisher: BioMed Central | Publication date: 2022-12-29

Original document: PMC | Score: 7.26731 | Text size: 57449 | Find: similar documents

S6 (C29H24N6O2S, molecular weight 520.62, Chemdiv, USA) was dissolved in PBS and adjusted to different concentrations for BLI.

Huanglongbing Pandemic: Current Challenges and Emerging Management Strategies

Dilip Ghosh; Sunil Kokane; Brajesh Kumar Savita; Pranav Kumar; Ashwani Kumar Sharma; Ali Ozcan; Amol Kokane; Swadeshmukul Santra; Subhas Hajeri; Madhurababu Kunta

PMC ID: PMC9824665 | DOI: 10.3390/plants12010160 | Journal: Plants, 12(1) | Publisher: MDPI | Publication date: 2022-12-29

Original document: PMC | Score: 3.1194367 | Text size: 225215 | Find: similar documents

The identified compound ChemDiv C549-0604 specifically inhibits the activity of CLas transcription regulator VisN [161,162,163,164,165], which suggests that the small lead molecules that target transcription regulators of CLas can potentially mitigate HLB.

Identification of probable inhibitors for the DNA polymerase of Monkeypox virus through the virtual screening approach

Swati Kumari; Sayan Chakraborty; Mohammed Ahmad; Varun Kumar; Prafullakumar B. Tailor; Bichitra K. Biswal

Original document: PMC | Score: 11.093979 | Text size: 53650 | Find: similar documents

To identify MPXV DPol specific inhibitors, we screened two compound libraries: drug-like molecules (available at ZINC database [41]) and the antiviral annotated library (ChemDiv, available at https://www.chemdiv.com/catalog/sets/Antiviral annotated-library/). ... In this study, about 7.5 million drug-like compounds from the ZINC database and 21,667 antiviral annotated compounds from ChemDiv Library were virtually screened for identifying the molecule with potential drug-like features.

Ligand-Based Drug Design of Novel Antimicrobials against Staphylococcus aureus by Targeting Bacterial Transcription

Jiqing Ye; Xiao Yang; Cong Ma; Giulio Vistoli

PMC ID: PMC9820117 | DOI: 10.3390/ijms24010339 | Journal: International Journal of Molecular Sciences, 24(1) | Publisher: MDPI | Publication date: 2022-12-25

Original document: PMC | Score: 11.093979 | Text size: 52980 | Find: similar documents

The ligand-based models—including the pharmacophore model, 3D QSAR, AutoQSAR, and ADME/T calculation—were integrated and used in the following virtual screening of the ChemDiv PPI database. ... The selected pharmacophore model was used for pharmacophore-based virtual screening of a focused compounds library from ChemDiv containing 222,447 molecules.

Anti-tuberculosis drug development via targeting the cell envelope of Mycobacterium tuberculosis

Xinyue Xu; Baoyu Dong; Lijun Peng; Chao Gao; Zhiqun He; Chuan Wang; Jumei Zeng

PMC ID: PMC9810820 | DOI: 10.3389/fmicb.2022.1056608 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-21

Original document: PMC | Score: 7.26731 | Text size: 59469 | Find: similar documents

Kumar et al. (2020) analyzed two peptide compound libraries (Asinex and ChemDiv) based on the structure of MurA, and they found that four compounds have acceptable pharmacokinetic properties.

Identification of a small molecule 0390 as a potent antimicrobial agent to combat antibiotic-resistant Escherichia coli

Linhui Li; Pengfei She; Shasha Liu; Yimin Li; Zehao Li; Yifan Yang; Linying Zhou; Yong Wu

PMC ID: PMC9800007 | DOI: 10.3389/fmicb.2022.1078318 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-15

Original document: PMC | Score: 7.713231 | Text size: 53444 | Find: similar documents

The MINI Scaffold library contains a total of 5,033 molecules with its own scaffold based on more than 16,000,000 drug-like small molecules from ChemDiv.

A Comprehensive Survey of Prospective Structure-Based Virtual Screening for Early Drug Discovery in the Past Fifteen Years

Hui Zhu; Yulin Zhang; Wei Li; Niu Huang; Alexandre G. de Brevern

PMC ID: PMC9781938 | DOI: 10.3390/ijms232415961 | Journal: International Journal of Molecular Sciences, 23(1) | Publisher: MDPI | Publication date: 2022-12-15

Original document: PMC | Score: 7.26731 | Text size: 64384 | Find: similar documents

1/15/n.a. (SPECS and Chemdiv libraries)

In silico high-throughput screening system for AKT1 activators with therapeutic applications in sepsis acute lung injury

Ziyi Wang; Xuesong Wang; Zhe Guo; Haiyan Liao; Yan Chai; Ziwen Wang; Zhong Wang

PMC ID: PMC9792167 | DOI: 10.3389/fcimb.2022.1050497 | Journal: Frontiers in Cellular and Infection Microbiology, 12(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-12

Original document: PMC | Score: 17.515972 | Text size: 46829 | Find: similar documents

The current study was aim to construct a high-throughput screening (HTS) system based on the ChemDiv database ( ... Based on the existing X-ray structure of AKT1 and known AKT activators, a large-scale virtual HTS was performed on the ChemDiv database of small molecules by the cascade docking method and demonstrated both accuracy and screening efficiency. ... The pharmacophore model of SC79 was used to match the ChemDiv pharmacophore database model. ... The original ChemDiv Database contained 2091084 compounds, and after preprocessing, it contained 2465124 compounds. ... ChemDiv pharmacophore database model was constructed by using each molecule of ChemDiv database to generate pharmacophore model.

Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth

Karthiga Santhana Kumar; Cyrill Brunner; Matthias Schuster; Levi Luca Kopp; Alexandre Gries; Shen Yan; Simon Jurt; Kerstin Moehle; Dominique Bruns; Michael Grotzer; Oliver Zerbe; Gisbert Schneider; Martin Baumgartner

Original document: PMC | Score: 8.19944 | Text size: 109900 | Find: similar documents

Collection of commercially available fast-delivery compounds of the suppliers Asinex Corp., ChemBridge Corp., ChemDiv, Enamine, Specs, UkrOrgSyntez Ltd. ... The generated pharmacophore was run against a database containing all fast-delivery compounds of the suppliers Asinex Corp., ChemBridge Corp., ChemDiv, Enamine, Specs, UkrOrgSyntez Ltd.

DrugCentral 2023 extends human clinical data and integrates veterinary drugs

Sorin Avram; Thomas B Wilson; Ramona Curpan; Liliana Halip; Ana Borota; Alina Bora; Cristian G Bologa; Jayme Holmes; Jeffrey Knockel; Jeremy J Yang; Tudor I Oprea

Original document: PMC | Score: 7.713231 | Text size: 56955 | Find: similar documents

He served on the Scientific Advisory Board of ChemDiv Inc. and InSilico Medicine.

A Subset Screen of the Compounds Australia Scaffold Library Identifies 7-Acylaminodibenzoxazepinones as Potent and Selective Hits for Anti-Giardia Drug Discovery

Christopher J. S. Hart; Andrew G. Riches; Snigdha Tiash; Erin Clapper; Soumya Ramu; Johannes Zuegg; John H. Ryan; Tina S. Skinner-Adams; Péter Mátyus

PMC ID: PMC9775191 | DOI: 10.3390/biomedicines10123182 | Journal: Biomedicines, 10(1) | Publisher: MDPI | Publication date: 2022-12-08

Original document: PMC | Score: 12.167842 | Text size: 44268 | Find: similar documents

SN00797640 (M013-0086) and SN00776497 (ZZ22822646) were repurchased from ChemDiv (San Diego, CA, USA) and Enamine (Kyiv, Ukraine) respectively for additional activity assays. ... However, the set are a series of regioisomeric 7-acylamides (ChemDiv personal communication and [22]).

Mechano-biochemical marine stimulation of inversion, gastrulation, and endomesoderm specification in multicellular Eukaryota

Ngoc Minh Nguyen; Tatiana Merle; Florence Broders-Bondon; Anne-Christine Brunet; Aude Battistella; Emelie Britt Linnea Land; Florian Sarron; Aditya Jha; Jean-Luc Gennisson; Eric Röttinger; María Elena Fernández-Sánchez; Emmanuel Farge

PMC ID: PMC9754125 | DOI: 10.3389/fcell.2022.992371 | Journal: Frontiers in Cell and Developmental Biology, 10(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-01

Original document: PMC | Score: 9.088693 | Text size: 94365 | Find: similar documents

The S381-0393 small molecule (https://www.chemdiv.com/search-element.php?q=S381-0393) has been selected in silico by ChemDiv upon request from in silico-designed inhibitors of βcat signaling targeting all of the βcat reactive and protein interacting site (https://www.chemdiv.com/catalog/focused-and-targeted-libraries/inhibitors-of-beta-catenin-signaling/?sphrase-id=40485). ... The S381-0393 was selected by ChemDiv as a specific inhibitor of Y654-βcat phosphorylation by mimicking best the α-helix subdomain of E-cadherin that includes I657, A656, and D665 and interacts with Y654 βcat to dock Y654-bcat and thus prevent its phosphorylation.

Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex

Yongmei Feng; Stefan Grotegut; Predrag Jovanovic; Valentina Gandin; Steven H. Olson; Rabi Murad; Anne Beall; Sharon Colayco; Paul De-Jesus; Sumit Chanda; Brian P. English; Robert H. Singer; Michael Jackson; Ivan Topisirovic; Ze’ev A. Ronai

PMC ID: PMC9751428 | DOI: 10.3389/fphar.2022.1029093 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-12-01

Original document: PMC | Score: 6.5141163 | Text size: 73068 | Find: similar documents

We used a large library of approximately 320,000 compounds selected from a pool of over three million compounds from five chemical vendors (ChemBridge, Asinex, Enamine, Life Chemicals, and ChemDiv).

Evaluation of action of steroid molecules on SARS-CoV-2 by inhibiting NSP-15, an endoribonuclease

Anantha Krishnan Dhanabalan; Sriram Srinivasa Raghavan; Selvakumar Rajendran; Velavan Ramasamy; Shaik Abdul Azeez Abdul; Nandhagopal Narayanasamy; Gunasekaran Krishnasamy

Original document: PMC | Score: 16.647287 | Text size: 29129 | Find: similar documents

A total of 533 steroid like compounds were retrieved from ChemDiv database and eight steroid compounds with anti-viral activity as reported [2] were chosen for the structure based virtual screening against NSP-15 protein target. ... To identify a suitable steroid like ligand against NSP-15, ChemDiv DB chemical database was used and SBVS protocol was employed. ... The library of 533 steroids compounds from ChemDIV database was screened against NSP-15 through structure based docking using glide XP module. ... From these analysis, three compounds from ChemDIV (0449-0045, N001-0004, N006-0008) and two compounds (Dexamethasone and Cortisone) from tested compounds were identified as potential compounds based on glide scoring function and ligand–protein interaction profiles.

Discovery of novel DNA‐damaging agents through phenotypic screening for DNA double‐strand break

Doudou Zhang; Takashi Shimokawa; Qianqian Guo; Shingo Dan; Yoshio Miki; Shigeaki Sunada

Original document: PMC | Score: 9.822761 | Text size: 30966 | Find: similar documents

DDA‐1 was obtained from Enamine; analogue numbers 1, 4, 6, 7, 8, and 9 were from Pharmeks, 2 and 5 were from ChemDiv, 3 and 11 from Vitas‐M, and 10 from Life Chemicals.

Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis

Matic Proj; Martina Hrast; Gregor Bajc; Rok Frlan; Anže Meden; Matej Butala; Stanislav Gobec

Original document: PMC | Score: 14.207614 | Text size: 54004 | Find: similar documents

For fragment library preparation, we selected compounds from more than 4500 in-house chemicals and more than 1.57 million compounds available for cherry-picking from ChemDiv (the database was downloaded on 05 October 2020). ... Compound were purchased from several vendors (ChemBridge Corporation, ChemDiv, Enamine, Maybridge, Vitas-M Laboratory, and Wuxi LabNetwork) and used as received. ... (2-Ethoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)(pyridin-2-yl)methanone (6, ChemDiv, S422-0111) ... 7–(4-Chlorophenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (12, ChemDiv, C201-1701)

Pharos 2023: an integrated resource for the understudied human proteome

Keith J Kelleher; Timothy K Sheils; Stephen L Mathias; Jeremy J Yang; Vincent T Metzger; Vishal B Siramshetty; Dac-Trung Nguyen; Lars Juhl Jensen; Dušica Vidović; Stephan C Schürer; Jayme Holmes; Karlie R Sharma; Ajay Pillai; Cristian G Bologa; Jeremy S Edwards; Ewy A Mathé; Tudor I Oprea

Original document: PMC | Score: 7.713231 | Text size: 55875 | Find: similar documents

He served on the scientific advisory board of ChemDiv Inc. and InSilico Medicine.

Discovery of novel anti-tumor compounds targeting PARP-1 with induction of autophagy through in silico and in vitro screening

Danfeng Shi; Qianqian Pang; Qianyu Qin; Xinsheng Yao; Xiaojun Yao; Yang Yu

PMC ID: PMC9638114 | DOI: 10.3389/fphar.2022.1026306 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-10-24

Original document: PMC | Score: 15.052543 | Text size: 57102 | Find: similar documents

Four compounds (Chemdiv codes: 8012-0567, 8018-6529, 8018-7168, 8018-7603) were proved with above 40% inhibitory ratio targeting PARP-1 under 20 μM, and further performed binding mode prediction and dynamic effect evaluation by molecular dynamics simulation. ... Then, a protocol of virtual screening workflow is evaluated and designed for the discovery of novel scaffolds of PARP-1 inhibitors, and 20 compounds were purchased from the Chemdiv database for in vitro assays. ... The Chemdiv database (https://www.chemdiv.com/) that contains over 1.5 million compounds was applied for the screening of PARP-1 inhibitors.

Mind the Gap—Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence

Theresa Noonan; Katrin Denzinger; Valerij Talagayev; Yu Chen; Kristina Puls; Clemens Alexander Wolf; Sijie Liu; Trung Ngoc Nguyen; Gerhard Wolber; Pavel Polishchuk; Thomas Seidel

PMC ID: PMC9695541 | DOI: 10.3390/ph15111304 | Journal: Pharmaceuticals, 15(1) | Publisher: MDPI | Publication date: 2022-10-22

Original document: PMC | Score: 7.697359 | Text size: 125521 | Find: similar documents

The optimized model was then used as the first VS step filtering the ChemDiv library with 1,492,362 compounds yielding 141,916 compounds. ... The DNN and CNN classification models were then used to screen the ChemDiv library (1178506 compounds).

An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

Alessia Caputo; Sara Sartini; Elisabetta Levati; Ilaria Minato; Gian Marco Elisi; Adriana Di Stasi; Catherine Guillou; Peter G. Goekjian; Pierre Garcia; David Gueyrard; Stéphane Bach; Arnaud Comte; Simone Ottonello; Silvia Rivara; Barbara Montanini; Florie Desriac; Yannick Fleury

PMC ID: PMC9598883 | DOI: 10.3390/antibiotics11101449 | Journal: Antibiotics, 11(1) | Publisher: MDPI | Publication date: 2022-10-21

Original document: PMC | Score: 7.713231 | Text size: 53659 | Find: similar documents

Compound 4 was purchased from ChemDiv (San Diego, CA, USA).

Small-molecule Wnt inhibitors are a potential novel therapy for intestinal fibrosis in Crohns disease

Amy Lewis; Saray Sánchez; Giulio Berti; Belen Pan-Castillo; Anke Nijhuis; Shameer Mehta; Liliane Eleid; Hannah Gordon; Radha Gadhok; Christopher Kimberley; Annamaria Minicozzi; Joanne Chin-Aleong; Roger Feakins; Robert Kypta; James Oliver Lindsay; Andrew Silver

Original document: PMC | Score: 6.8701305 | Text size: 72844 | Find: similar documents

For all cell treatments, cells were serum starved overnight prior to 48 h treatment with 10 μM ICG-001 dissolved in DMSO, or 100 nM porcupine inhibitor Wnt-C59 (Selleckchem S7037), or 10 μM FZD8 inhibitor 3235-0367 (C1, ChemDiv), alone or in combination with 10 ng/mL-recombinant human TGFβ1 (R&D Systems).

The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation

Radwa E. Mahgoub; Feda E. Mohamed; Lara Alzyoud; Bassam R. Ali; Juliana Ferreira; Wael M. Rabeh; Shaikha S. AlNeyadi; Noor Atatreh; Mohammad A. Ghattas; Dmitri B. Kireev

PMC ID: PMC9572942 | DOI: 10.3390/molecules27196710 | Journal: Molecules, 27(1) | Publisher: MDPI | Publication date: 2022-10-09

Original document: PMC | Score: 10.625123 | Text size: 61128 | Find: similar documents

A total of 178 compounds from all the screened libraries (i.e., TimTec: 59, ChEMBL: 48, and ChemDiv: 60) were further investigated using MD simulation and MM-GBSA scoring. ... Four libraries were initially downloaded for virtual screening: NCI [40], TimTec [41], ChEMBL [42], and ChemDiv [43].

Identification of a novel specific small-molecule melanocortin-2-receptor antagonist

Rachel Forfar; Mashal Hussain; Puneet Khurana; Jennifer Cook; Steve Lewis; Dillon Popat; David Jackson; Ed McIver; Jeff Jerman; Debra Taylor; Adrian JL Clark; Li F Chan

PMC ID: PMC9641778 | DOI: 10.1530/EC-22-0338 | Journal: Endocrine Connections, 11(1) | Publisher: Bioscientifica Ltd | Publication date: 2022-10-06

Original document: PMC | Score: 9.822761 | Text size: 30319 | Find: similar documents

The eight chemical libraries used in our screening were as follows: LOPAC1280 (Sigma-Aldrich), HitFinder (Maybridge, Cornwall, UK), bioactive compounds (InterBioScreen, Moscow, Russia), BBP-2080 library (BioBiopha, Kunming, China), MEGxm and MEGxp (Analy-Ticon Discovery, Potsdam, Germany), Prestwick chemical library (Prestwick, Illkirch, France), Tocriscreen Total (Tocris, Bristol, UK), and GPCR-targeted library (ChemDiv, San Diego, CA, USA).

Discovery of novel SARS-CoV-2 3CL protease covalent inhibitors using deep learning-based screen

Liying Wang; Zhongtian Yu; Shiwei Wang; Zheng Guo; Qi Sun; Luhua Lai

Original document: PMC | Score: 7.713231 | Text size: 50048 | Find: similar documents

Cysteine Targeted Covalent Library from ChemDiv (https://www.chemdiv.com) contains 39, 301 compounds that have specific warheads, which were designed to react with cysteine.

High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors

Yi Zang; Mingbo Su; Qingxing Wang; Xi Cheng; Wenru Zhang; Yao Zhao; Tong Chen; Yingyan Jiang; Qiang Shen; Juan Du; Qiuxiang Tan; Peipei Wang; Lixin Gao; Zhenming Jin; Mengmeng Zhang; Cong Li; Ya Zhu; Bo Feng; Bixi Tang; Han Xie; Ming-Wei Wang; Mingyue Zheng; Xiaoyan Pan; Haitao Yang; Yechun Xu; Beili Wu; Leike Zhang; Zihe Rao; Xiuna Yang; Hualiang Jiang; Gengfu Xiao; Qiang Zhao; Jia Li

Original document: PMC | Score: 7.713231 | Text size: 54823 | Find: similar documents

The ~1,800,000 compounds of CNCL bought from ChemDiv (USA), ChemBridge (USA), Life Chemicals (Canada), Specs (Holland) and donated by NovoNordisk (Denmark) were primarily screened against Mpro and PLpro at the concentration of 10 and 8 μg/mL respectively.

Lin28 Regulates Cancer Cell Stemness for Tumour Progression

Zhuohui Lin; Mariia Radaeva; Artem Cherkasov; Xuesen Dong; Kavita Shah

PMC ID: PMC9564245 | DOI: 10.3390/cancers14194640 | Journal: Cancers, 14(1) | Publisher: MDPI | Publication date: 2022-09-24

Original document: PMC | Score: 5.6376715 | Text size: 87902 | Find: similar documents

127,007 compounds from LOPAC, Prestwick, Maybridge, ChemDiv, and UMich libraries

Identification and characterization of a novel SNAT2 (SLC38A2) inhibitor reveals synergy with glucose transport inhibition in cancer cells

Gregory Gauthier-Coles; Angelika Bröer; Malcolm Donald McLeod; Amee J. George; Ross D. Hannan; Stefan Bröer

PMC ID: PMC9532951 | DOI: 10.3389/fphar.2022.963066 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-21

Original document: PMC | Score: 18.556135 | Text size: 77822 | Find: similar documents

ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv ... ChemDiv

Highly multiplexed selection of RNA aptamers against a small molecule library

Brent Townshend; Matias Kaplan; Christina D. Smolke; Floyd Romesberg

PMC ID: PMC9477273 | DOI: 10.1371/journal.pone.0273381 | Journal: PLoS ONE, 17(1) | Publisher: Public Library of Science | Publication date: 2022-09-15

Original document: PMC | Score: 12.764881 | Text size: 80266 | Find: similar documents

The target compound library comprises 5,120 small molecule compounds randomly selected from a ChemDiv representative diversity library obtained via the Stanford High-Throughput Bioscience Center [22]. ... However, the second-sourced sample of CDIQ165-N09 showed a clear peak with an m/z corresponding to an M+H adduct of the expected chemical whereas the ChemDiv sample showed no corresponding peak. ... Thus, the difference in observed responses is likely due to the expected chemical not being present in the ChemDiv sample at the expected concentration, possibly caused by degradation or handling of the library prior to our work.

Review of in silico studies dedicated to the nuclear receptor family: Therapeutic prospects and toxicological concerns

Asma Sellami; Manon Réau; Matthieu Montes; Nathalie Lagarde

PMC ID: PMC9513233 | DOI: 10.3389/fendo.2022.986016 | Journal: Frontiers in Endocrinology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-13

Original document: PMC | Score: 4.780143 | Text size: 122095 | Find: similar documents

ChemDiv database (7476 compounds) for prospective screening

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Enrique Crisman; Pablo Duarte; Esteban Dauden; Antonio Cuadrado; María Isabel Rodríguez‐Franco; Manuela G. López; Rafael León

Original document: PMC | Score: 3.892117 | Text size: 165955 | Find: similar documents

Kim et al. 136 identified compound 53 (Table 2) after performing a virtual screening of Asinex and Chemdiv chemical libraries using a ligand‐based pharmacophore, structure‐based pharmacophore, and docking combination strategy.

Discovery of novel IDH1-R132C inhibitors through structure-based virtual screening

Chujiao Hu; Zhirui Zeng; Dan Ma; Zhixin Yin; Shanshan Zhao; Tengxiang Chen; Lei Tang; Shi Zuo

PMC ID: PMC9491111 | DOI: 10.3389/fphar.2022.982375 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-07

Original document: PMC | Score: 13.219877 | Text size: 50053 | Find: similar documents

ChemDiv (2019 version) database with more than 1.5 million molecules was used for the virtual screening. ... ChemDiv, a sub-database of the ZINC15 database, was used as the virtual screening library. ... In summary, the study identified a potent IDH1-R132C inhibitor based on molecular docking-based virtual screening using the ChemDiv database and cellular assays.

Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

Bingwu Wang; Jian Gao; Zhongjun Zhao; Xuefei Zhong; Hao Cui; Hui Hou; Yanping Zhang; Junnian Zheng; Jiehui Di; Yong Liu

Original document: PMC | Score: 7.713231 | Text size: 49706 | Find: similar documents

The small molecule database used as the screening library was the ChemDiv database (commercially available) from TopScience Co. (Shanghai, China), which comprises more than 1 million compounds.

Small molecule SJ572946 activates BAK to initiate apoptosis

Giridhar Sekar; Geetika Singh; Xingping Qin; Cristina D. Guibao; Brittany Schwam; Zintis Inde; Christy R. Grace; Weixing Zhang; P. Jake Slavish; Wenwei Lin; Taosheng Chen; Richard E. Lee; Zoran Rankovic; Kristopher Sarosiek; Tudor Moldoveanu

PMC ID: PMC9485059 | DOI: 10.1016/j.isci.2022.105064 | Journal: iScience, 25(1) | Publisher: Elsevier | Publication date: 2022-09-06

Original document: PMC | Score: 5.6376715 | Text size: 89818 | Find: similar documents

ChemDiv

Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype

Tiffany S. Dwyer; Joseph B. O’Brien; Christopher P. Ptak; Justin E. LaVigne; Daniel P. Flaherty; Val J. Watts; David L. Roman

PMC ID: PMC9486168 | DOI: 10.3389/fphar.2022.977742 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-09-06

Original document: PMC | Score: 16.915955 | Text size: 84849 | Find: similar documents

ChemDiv CNS targeted library FP screen ... For the ChemDiv CNS targeted library (ChemDiv, San Diego, CA) of compounds, the protocol is the same as that outlined for the FDA-approved library, with minor differences as the MMSP and ChemBridge DIVERSet libraries. ... The test plate’s final ChemDiv CNS targeted compounds’ concentration was 14.64 μM (0.147% DMSO). ... The ChemDiv CNS targeted library (CDI, ChemDiv, San Diego, CA) is comprised of compounds selected for CNS protein targets (98 protein sub-families/unit targets) based on literature searches (ranging from 2014-present) as well as novel X-ray and Cryo-EM structures deposited in the PDB.

Virtual Screening in the Identification of Sirtuins’ Activity Modulators

Elena Abbotto; Naomi Scarano; Francesco Piacente; Enrico Millo; Elena Cichero; Santina Bruzzone; Dmitri B. Kireev

PMC ID: PMC9457788 | DOI: 10.3390/molecules27175641 | Journal: Molecules, 27(1) | Publisher: MDPI | Publication date: 2022-09-01

Original document: PMC | Score: 12.4384985 | Text size: 182466 | Find: similar documents

They were merged together to form a single dynamic pharmacophore model, which was then used to screen the CHEMDIV database [258]. ... Maybridge (60,000), Chembridge (50,000), NCI (200,000), and ChemDiv (700 000) ... CHEMDIV database (700 000) ... Specs, ChemDiv, Selleck, and MedChemExpress and in-house database ... Chemdiv database (939319) ... More recently, in 2020, compound Hit20 was also discovered as SIRT-6 activator, thanks to molecular docking adopted to screen commercial chemical databases including Specs, ChemDiv, Selleck, and MedChemExpress, as well as an in-house database (see Section 2.6.1) [173]. ... Subsequent VS screening was carried out by Autodock Vina [301] by taking into account the Chemdiv database [258] containing 939,319 structurally diverse compounds.

Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma

Valeria Napolitano; Charlotte A. Softley; Artur Blat; Vishal C. Kalel; Kenji Schorpp; Till Siebenmorgen; Kamyar Hadian; Ralf Erdmann; Michael Sattler; Grzegorz M. Popowicz; Grzegorz Dubin

PMC ID: PMC9424529 | DOI: 10.1038/s41598-022-18841-1 | Journal: Scientific Reports, 12(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-08-29

Original document: PMC | Score: 9.45341 | Text size: 34007 | Find: similar documents

An in-house 30,000 molecules diversity set (ChemBridge, ChemDiv, Enamine, PPI) and FDA-approved drug library were used in high throughput screening.

New inhibitors of cathepsin V impair tumor cell proliferation and elastin degradation and increase immune cell cytotoxicity

Ana Mitrović; Emanuela Senjor; Marko Jukić; Lara Bolčina; Mateja Prunk; Matic Proj; Milica Perišić Nanut; Stanislav Gobec; Janko Kos

PMC ID: PMC9459403 | DOI: 10.1016/j.csbj.2022.08.046 | Journal: Computational and Structural Biotechnology Journal, 20(1) pp. 4667-4687 | Publisher: Research Network of Computational and Structural Biotechnology | Publication date: 2022-08-28

Original document: PMC | Score: 5.6376715 | Text size: 90683 | Find: similar documents

Compounds were obtained from various sources (Life Chemicals, ENAMINE, Vitas-M, ChemDiv, UkrOrgSynthesis, Otava ltd in InterBioScreen) and used as received.

Hydrogen bonding penalty used for virtual screening to discover potent inhibitors for Papain‐Like cysteine proteases of SARS‐CoV‐2

Guangjian Zhao; Xiaochun Liu; Suyun Wang; Zhongyue Bai; Siyu Zhang; Yifan Wang; Haibo Yu; Ximing Xu

Original document: PMC | Score: 8.217452 | Text size: 46817 | Find: similar documents

The ligand library is taken from “TargetMol, USA” (ChemDiv and “Bioactive Compound Library”).

Molecular docking and dynamics based approach for the identification of kinase inhibitors targeting PI3Kα against non-small cell lung cancer: a computational study†

Debojyoti Halder; Subham Das; Aiswarya R.; Jeyaprakash R. S.

PMC ID: PMC9346375 | DOI: 10.1039/d2ra03451d | Journal: RSC Advances, 12(1) pp. 21452-21467 | Publisher: The Royal Society of Chemistry | Publication date: 2022-07-21

Original document: PMC | Score: 13.219877 | Text size: 49098 | Find: similar documents

In this research work, a specific biological target PI3Kα, which has a pan and a selective inhibitor, was selected and a kinase inhibitor database of 36 324 molecules from ChemDiv was chosen for the structure-based virtual screening to obtain the top ten hits, for further MMGBSA free binding energy analysis, ADMET predictions, IFD (induced fit docking) analysis and MD (molecular dynamics) simulations for the optimization of the kinase inhibitors for pan and selective inhibition of PI3Kα in the treatment of NSCLC squamous carcinoma. ... PI3K is a kind of kinase enzyme which readily mutates in squamous cell carcinoma in NSCLC, and therefore, the kinase inhibitor library from ChemDiv was chosen for the virtual screening.

Virtual Screening of Substances Used in the Treatment of SARS-CoV-2 Infection and Analysis of Compounds With Known Action on Structurally Similar Proteins From Other Viruses

Paul Andrei Negru; Denisa Claudia Miculas; Tapan Behl; Alexa Florina Bungau; Ruxandra-Cristina Marin; Simona Gabriela Bungau

Original document: PMC | Score: 6.1931806 | Text size: 81496 | Find: similar documents

ChemDiv

Screening for positive allosteric modulators of cholecystokinin type 1 receptor potentially useful for management of obesity

Daniela G. Dengler; Qing Sun; Kaleeckal G. Harikumar; Laurence J. Miller; Eduard A. Sergienko

Original document: PMC | Score: 7.26731 | Text size: 59423 | Find: similar documents

(Camelford, Cornwall, UK), ChemBridge Corporation (San Diego, CA, USA), ChemDiv, Inc.

A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer

Vaishnavi Muralikrishnan; Fang Fang; Tyler C. Given; Ram Podicheti; Mikhail Chtcherbinine; Tara X. Metcalfe; Shruthi Sriramkumar; Heather M. O’Hagan; Thomas D. Hurley; Kenneth P. Nephew; Christina M. Annunziata; Adam R. Karpf

PMC ID: PMC9318275 | DOI: 10.3390/cancers14143437 | Journal: Cancers, 14(1) | Publisher: MDPI | Publication date: 2022-07-15

Original document: PMC | Score: 11.093979 | Text size: 59259 | Find: similar documents

Compounds purchased from ChemDiv Corporation (San Diego, CA, USA) and ChemBridge Corporation (San Diego, CA, USA) were >95% pure based on vendor specifications (NMR spectra for the compounds can be found in the ). ... To avoid the potential off-target effects due to the structure of CM38, 974 was chosen amongst the ALDH1A1 inhibitors with high structural similarity to CM38 from commercial sources (ChemDiv Corporation and ChemBridge Corporation, San Diego, CA, USA).

Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors

Aliakbar Khalili Yazdi; Paknoosh Pakarian; Sumera Perveen; Taraneh Hajian; Vijayaratnam Santhakumar; Albina Bolotokova; Fengling Li; Masoud Vedadi

PMC ID: PMC9305828 | DOI: 10.1021/acsinfecdis.2c00165 | Journal: ACS Infectious Diseases | Publisher: American Chemical Society | Publication date: 2022-07-13

Original document: PMC | Score: 11.093979 | Text size: 51452 | Find: similar documents

SARS-CoV-2 nsp13 was screened against a library of potential kinase inhibitors containing 5000 small molecules (ChemDiv Kinase Library) at 50 μM using the optimized ssDNA+ ATPase assay. ... Protein expression and purification details, ChemDiv catalogue numbers for selected eight reproducible hits, detection of nsp13 ATPase activities using the bioluminescence assays, SARS-CoV-2 nsp13 purification, assay optimization, tests of the top eight hits in a counter screen, and dose-response analysis of six hits from the original in-house samples (PDF)

Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells

Katherine Chew; Branden Lee; Simon D. van Haren; Etsuro Nanishi; Timothy O’Meara; Jennifer B. Splaine; Maria DeLeon; Dheeraj Soni; Hyuk-Soo Seo; Sirano Dhe-Paganon; Al Ozonoff; Jennifer A. Smith; Ofer Levy; David J. Dowling

PMC ID: PMC9298130 | DOI: 10.1101/2022.06.17.496630 | Journal: bioRxiv | Publisher: Cold Spring Harbor Laboratory | Publication date: 2022-07-11

Original document: PMC | Score: 6.8701305 | Text size: 70072 | Find: similar documents

704 molecules were chosen for known activity toward PBMCs; these molecules filled up two library plates and originated from the ChemDiv6 library (ChemDiv Inc, San Diego, CA).

CDI Exerts Anti-Tumor Effects by Blocking the FoxM1-DNA Interaction

Woo Dae Jang; Mi Young Lee; Jihye Mun; Gyutae Lim; Kwang-Seok Oh; Seungho Baek

PMC ID: PMC9313426 | DOI: 10.3390/biomedicines10071671 | Journal: Biomedicines, 10(1) | Publisher: MDPI | Publication date: 2022-07-11

Original document: PMC | Score: 8.217452 | Text size: 46289 | Find: similar documents

CDI (CAT#, NO75-0015) was obtained from ChemDiv (San Diego, CA, USA).

Fragment‐based drug discovery—the importance of high‐quality molecule libraries

Marta Bon; Alan Bilsland; Justin Bower; Kirsten McAulay

Original document: PMC | Score: 9.797036 | Text size: 78283 | Find: similar documents

(A) General fragment sets were obtained from Maybridge (30 061 compounds), Life Chemicals (50 597 compounds), Enamine (172 689 compounds) and ChemDiv (11 269 compounds). ... High Fidelity Library (1920 compounds); Life Chemicals, General Fragment Library (50 607 compounds); ChemDiv, Fragments Library (11 269 compounds); Bionet, 2nd Generation Premium Library (1166 compounds).

Characterization of Dense Granule Metalloproteinase INS-16 in Cryptosporidium parvum

Hao Cui; Rui Xu; Yu Li; Yaqiong Guo; Ziding Zhang; Lihua Xiao; Yaoyu Feng; Na Li; Cristina Sánchez-Camacho

PMC ID: PMC9315855 | DOI: 10.3390/ijms23147617 | Journal: International Journal of Molecular Sciences, 23(1) | Publisher: MDPI | Publication date: 2022-07-10

Original document: PMC | Score: 12.167842 | Text size: 41216 | Find: similar documents

Although we failed to obtain the full INS-16 protein with enzymatic activity, based on the structure of human IDE together with known inhibitors, we were able to simulate the active structure of INS-16, leading to the identification of 48 potential inhibitors from the ChemDiv database through molecular docking. ... A total of 48 compounds were selected from the ChemDiv database through the molecular docking of INS-16 as described previously [30] (Table 1).

Modulating mitofusins to control mitochondrial function and signaling

Emmanouil Zacharioudakis; Bogos Agianian; Vasantha Kumar MV; Nikolaos Biris; Thomas P. Garner; Inna Rabinovich-Nikitin; Amanda T. Ouchida; Victoria Margulets; Lars Ulrik Nordstrøm; Joel S. Riley; Igor Dolgalev; Yun Chen; Andre J. H. Wittig; Ryan Pekson; Chris Mathew; Peter Wei; Aristotelis Tsirigos; Stephen W. G. Tait; Lorrie A. Kirshenbaum; Richard N. Kitsis; Evripidis Gavathiotis

PMC ID: PMC9262907 | DOI: 10.1038/s41467-022-31324-1 | Journal: Nature Communications, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-07-07

Original document: PMC | Score: 8.19944 | Text size: 107705 | Find: similar documents

Screened MASMs were purchased from Enamine, ChemBridge and ChemDiv. ... The rest of the screened MFIs were purchased from Enamine, ChemBridge, ChemDiv, Vitas M, and UORSY.

Glioblastoma: Current Status, Emerging Targets, and Recent Advances

Amandeep Thakur; Chetna Faujdar; Ram Sharma; Sachin Sharma; Basant Malik; Kunal Nepali; Jing Ping Liou

Original document: PMC | Score: 2.2328758 | Text size: 332970 | Find: similar documents

To establish the SAR, a total of 89 compounds from the Chemdiv library and NCI development program were tested using the PDI reductase assay.

Structure-based pharmacophore modeling, virtual screening, and molecular dynamics simulation studies for identification of Plasmodium falciparum 5-aminolevulinate synthase inhibitors

Gbolahan O. Oduselu; Rufus Afolabi; Ibitayo Ademuwagun; Ashley Vaughan; Ezekiel Adebiyi

PMC ID: PMC9877529 | DOI: 10.3389/fmed.2022.1022429 | Journal: Frontiers in Medicine, 9(1) | Publisher: Frontiers Media S.A. | Publication date: 2022

Original document: PMC | Score: 15.052543 | Text size: 54985 | Find: similar documents

The best model of the tertiary structure of Pf 5-ALAS was obtained using MolProbity, while the following databases were explored for the pharmacophore-based virtual screening: CHEMBL, ChemDiv, ChemSpace, MCULE, MCULE-ULTIMATE, MolPort, NCI Open Chemical Repository, LabNetwork and ZINC databases. ... The pharmacophore-based screening of the different databases (CHEMBL30, ChemDiv, ChemSpace, MCULE, MCULE-ULTIMATE, MolPort, NCI Open Chemical Repository, LabNetwork and ZINC) gave rise to 2,755 hits (Table 4). ... The total number of hits obtained from the databases are in the order: ChemSpace > ZINC > MCULE > MolPort > CHEMBL30 > ChemDiv > LabNetwork > NCI Open Chemical Repository > MCULE-ULTIMATE.

A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

Karel Miettinen; Nattawat Leelahakorn; Aldo Almeida; Yong Zhao; Lukas R. Hansen; Iben E. Nikolajsen; Jens B. Andersen; Michael Givskov; Dan Staerk; Søren Bak; Sotirios C. Kampranis

PMC ID: PMC9237071 | DOI: 10.1038/s41467-022-31357-6 | Journal: Nature Communications, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-06-27

Original document: PMC | Score: 5.9023848 | Text size: 90076 | Find: similar documents

ANT4 (#3888-1206) and ANT5 (#3909-7498) were bought from ChemDiv, US.

Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies

Said Moshawih; Ai Fern Lim; Chrismawan Ardianto; Khang Wen Goh; Nurolaini Kifli; Hui Poh Goh; Qais Jarrar; Long Chiau Ming; Supriyo Bhattacharya; Xiaolin Cheng

PMC ID: PMC9312989 | DOI: 10.3390/biom12070878 | Journal: Biomolecules, 12(1) | Publisher: MDPI | Publication date: 2022-06-23

Original document: PMC | Score: 4.780143 | Text size: 125484 | Find: similar documents

Commercially available protein-protein interaction small molecules from ChemDiv

Discovery and Characterization of Multiple Classes of Human CatSper Blockers

Erick J. Carlson; Rawle Francis; Yutong Liu; Ping Li; Maximilian Lyon; Celia M. Santi; Derek J. Hook; Jon E. Hawkinson; Gunda I. Georg

Original document: PMC | Score: 10.19429 | Text size: 65842 | Find: similar documents

Over 72,000 compounds from the following libraries were tested in the primary screen at 10 μM: the National Cancer Institute set, the ChemDiv Peptidomimetic and Kinase libraries, the TOCRIS Tocriscreen Complete and Kinase Inhibitor Library, the ChemBridge MicroFormat Library, the LOPAC library, the NIH Clinical Library, the Prestwick Chemical Library, and the MicroSource Spectrum Collection. ... [43] Hits 1 a and 2 a were identified from the LOPAC library, hits 3 a, 4 a, and 5 a came from the ChemBridge library, 6 a from the MicroSource library and compound 7 a from the ChemDiv kinase library.

Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility

Yukari Endo; Linda Groom; Alper Celik; Natalia Kraeva; Chang Seok Lee; Sung Yun Jung; Lois Gardner; Marie-Anne Shaw; Susan L. Hamilton; Philip M. Hopkins; Robert T. Dirksen; Sheila Riazi; James J. Dowling

PMC ID: PMC9192596 | DOI: 10.1038/s41467-022-31088-8 | Journal: Nature Communications, 13(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-06-13

Original document: PMC | Score: 6.5141163 | Text size: 73965 | Find: similar documents

To assess the motor function, 3-dpf fish were individually transferred to a 96-well plate and incubated with 10 μM optovin 6b8 (ChemDiv) at 28.5 °C for 5 min as previously described59.

Discovery of novel SARS-CoV-2 inhibitors targeting the main protease Mpro by virtual screenings and hit optimization

Beatrice Mercorelli; Jenny Desantis; Marta Celegato; Alessandro Bazzacco; Lydia Siragusa; Paolo Benedetti; Michela Eleuteri; Federico Croci; Gabriele Cruciani; Laura Goracci; Arianna Loregian

Original document: PMC | Score: 12.154662 | Text size: 61716 | Find: similar documents

In approaches (1-1) and (1–2) (Fig. 1B), a database of small molecules composed of structures from Specs and ChemDiv vendors (overall 793,212 compounds) was generated by applying the following filters: molecular weight range = 150–500; logP >5; protonation state = most abundant protomer at pH = 7.4; up to 50 conformers with RMSD >0.1. ... Compounds 1–5 were purchased from ChemDiv, compounds 6–8 from Specs, compounds 9–20 from Vitas-M, compound 21 from Fluorochem, and compounds 22–24 from Sigma Aldrich (more details in Dataset S1). ... First, we performed LBVS campaigns on N3 and 13b using a dataset of commercially available compounds (almost 800,000 small molecules from Specs and ChemDiv) employing the FLAP software (Baroni et al., 2007) (Fig. 1B, approaches 1-1 and 1–2).

Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease

Xiaodong Dou; Qi Sun; Guofeng Xu; Yameng Liu; Caifang Zhang; Bingding Wang; Yangbin Lu; Zheng Guo; Lingyu Su; Tongyu Huo; Xinyi Zhao; Chen Wang; Zhongtian Yu; Song Song; Liangren Zhang; Zhenming Liu; Luhua Lai; Ning Jiao

Original document: PMC | Score: 9.42958 | Text size: 73278 | Find: similar documents

A total of 70 compounds were captured and purchased from the ChemDiv and SPECS commercial databases. ... Compounds used for SARS-CoV-2 Mpro inhibitors screening were purchased from ChemDiv (https://www.chemdiv.com/) and SPECS (https://www.specs.net/) commercial databases.

ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL-8/Notch signaling cascade

Valerio Ciccone; Erika Terzuoli; Emma Ristori; Arianna Filippelli; Marina Ziche; Lucia Morbidelli; Sandra Donnini

Original document: PMC | Score: 6.1931806 | Text size: 79064 | Find: similar documents

The ALDH1A1 inhibitor CM037 was from ChemDiv Inc.

Characterization of Calcium-Dependent Protein Kinase 2A, a Potential Drug Target Against Cryptosporidiosis

Fanfan Shu; Yu Li; Wenlun Chu; Xuehua Chen; Ziding Zhang; Yaqiong Guo; Yaoyu Feng; Lihua Xiao; Na Li

PMC ID: PMC9090282 | DOI: 10.3389/fmicb.2022.883674 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-04-25

Original document: PMC | Score: 11.880346 | Text size: 45180 | Find: similar documents

Using molecular docking of the simulated CpCDPK2A structure, small molecules were selected from the ChemDiv database. ... A total of 50 compounds were selected from the ChemDiv core database according to the scores from molecular docking of CpCDPK2A (Table 1).

Novel Inhibitors of 2′-O-Methyltransferase of the SARS-CoV-2 Coronavirus

Alexey Sulimov; Danil Kutov; Ivan Ilin; Yibei Xiao; Sheng Jiang; Vladimir Sulimov; Athina Geronikaki

PMC ID: PMC9100384 | DOI: 10.3390/molecules27092721 | Journal: Molecules, 27(1) | Publisher: MDPI | Publication date: 2022-04-23

Original document: PMC | Score: 16.607422 | Text size: 42506 | Find: similar documents

Here, we performed high-throughput docking into the SAM-binding site of nsp16 for almost 40 thousand structures, prepared for compounds from three libraries: Enamine Coronavirus Library, Enamine Nucleoside Mimetics Library, and Chemdiv Nucleoside Analogue Library. ... The results of calculations for the best ligands and their structures are presented in Table 6 and Figure 8 (ligands selected from the Enamine Coronavirus Library) and Figure 9 (ligands selected from the Chemdiv Nucleoside Analogue Library), respectively. ... Similarly to sinefungin and SAM, three of the four top compounds from the Chemdiv Nucleoside Analogue Library belong to purines.

Identification of Potent and Selective JAK1 Lead Compounds Through Ligand-Based Drug Design Approaches

Sathya Babu; Santhosh Kumar Nagarajan; Sruthy Sathish; Vir Singh Negi; Honglae Sohn; Thirumurthy Madhavan

PMC ID: PMC9068899 | DOI: 10.3389/fphar.2022.837369 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-04-21

Original document: PMC | Score: 13.442831 | Text size: 85497 | Find: similar documents

Based on the validation results, the best pharmacophore models ADHRRR, DDHRRR, DDRRR, DPRRR, DHRRR, ADRRR, DDHRR, and ADPRR were selected and taken for virtual screening against the Maybridge, Asinex, Chemdiv, Enamine, Lifechemicals, and Zinc database to identify the new molecules with novel scaffold that can bind to JAK1. ... The selected pharmacophore models were screened against Maybridge, Lifechemicals, Enamine, Chemdiv, Asinex, and Zinc (chemical and natural) databases for the identification of new hits. ... The fitness score was set to >1.5 for the Maybridge, Asinex, Chemdiv, Lifechemicals, and Enamine databases, whereas for the Zinc database, the fitness score was set to >2 because of high number of molecules retrieved from the Zinc database.

Identifying New Ligands for JNK3 by Fluorescence Thermal Shift Assays and Native Mass Spectrometry

Chongyun Cheng; Miaomiao Liu; Xiaoqin Gao; Dong Wu; Mengchen Pu; Jun Ma; Ronald J. Quinn; Zhicheng Xiao; Zhijie Liu

PMC ID: PMC9088906 | DOI: 10.1021/acsomega.2c00340 | Journal: ACS Omega, 7(1) pp. 13925-13931 | Publisher: American Chemical Society | Publication date: 2022-04-14

Original document: PMC | Score: 9.110828 | Text size: 35916 | Find: similar documents

The compounds were purchased from ChemDiv and Enamine.

Identification of Novel Covalent XPO1 Inhibitors Based on a Hybrid Virtual Screening Strategy

Zheyuan Shen; Weihao Zhuang; Kang Li; Yu Guo; Bingxue Qu; Sikang Chen; Jian Gao; Jing Liu; Lei Xu; Xiaowu Dong; Jinxin Che; Qimeng Li; Dmitri B. Kireev

PMC ID: PMC9024667 | DOI: 10.3390/molecules27082543 | Journal: Molecules, 27(1) | Publisher: MDPI | Publication date: 2022-04-14

Original document: PMC | Score: 9.822761 | Text size: 33395 | Find: similar documents

To ensure the molecular diversity of our covalent compound library, compounds from ChemDiv compound libraries and TargetMol with well-developed skeleton diversities were initially included.

A Small Molecule Promoting Neural Differentiation Suppresses Cancer Stem Cells in Colorectal Cancer

Jung Kyu Choi; Ihn-Sil Kwak; Sae-Bom Yoon; Heeyeong Cho; Byoung-San Moon; Massimo Moro; Luca Falzone

PMC ID: PMC9025482 | DOI: 10.3390/biomedicines10040859 | Journal: Biomedicines, 10(1) | Publisher: MDPI | Publication date: 2022-04-06

Original document: PMC | Score: 8.792208 | Text size: 41016 | Find: similar documents

Specifically, we used a 2000-compound ChemDiv drug screening library platform to identify compounds that would decrease TOP-flash reporter activity in the HEK293 TCF/LEF cell line.

Targeting papain-like protease for broad-spectrum coronavirus inhibition

Shuofeng Yuan; Xiaopan Gao; Kaiming Tang; Jian-Piao Cai; Menglong Hu; Peng Luo; Lei Wen; Zi-Wei Ye; Cuiting Luo; Jessica Oi-Ling Tsang; Chris Chun-Yiu Chan; Yaoqiang Huang; Jianli Cao; Ronghui Liang; Zhenzhi Qin; Bo Qin; Feifei Yin; Hin Chu; Dong-Yan Jin; Ren Sun; Jasper Fuk-Woo Chan; Sheng Cui; Kwok-Yung Yuen

Original document: PMC | Score: 7.713231 | Text size: 55754 | Find: similar documents

The SmartTM chemical library was purchased from Chemdiv (San Diego, USA), which contains 50,080 small-molecule compounds with enhanced diversity and drug-like properties.

Advances in Pathogenesis, Progression, Potential Targets and Targeted Therapeutic Strategies in SARS-CoV-2-Induced COVID-19

Hong Zhou; Wei-Jian Ni; Wei Huang; Zhen Wang; Ming Cai; Yan-Cai Sun

PMC ID: PMC9016159 | DOI: 10.3389/fimmu.2022.834942 | Journal: Frontiers in Immunology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-04-05

Original document: PMC | Score: 3.892117 | Text size: 156041 | Find: similar documents

Virtual screening: High-throughput screening is carried out to identify possible lead compounds from existing compound databases, such as ZINC, DrugBank, or ChemDiv, on the basis of structural biology and homology modeling analysis of protein structure.

A combination screening to identify enhancers of para-aminosalicylic acid against Mycobacterium tuberculosis

Jinyeong Heo; Dahae Koh; Minjeong Woo; Doyoon Kwon; Virgínia Carla de Almeida Falcão; Connor Wood; Honggun Lee; Kideok Kim; Inhee Choi; Jichan Jang; Priscille Brodin; David Shum; Vincent Delorme

PMC ID: PMC8980009 | DOI: 10.1038/s41598-022-08209-w | Journal: Scientific Reports, 12(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-04-04

Original document: PMC | Score: 7.26731 | Text size: 57782 | Find: similar documents

A total of 104,783 small molecules were assembled, including 51,406 compounds from Enamine and 53,377 compounds from various suppliers: ChemDiv (12,270), ChemBridge (11,709), Life Chemicals (7917), Vitas-M (5000), Princeton BioMolecular Research (4751), InterBioScreen (3436), Otava Chemicals (3366), Thermo Fisher Scientific (Maybridge collection, 2951) and Specs (1977).

Proteostasis Regulators in Cystic Fibrosis: Current Development and Future Perspectives

Irene Brusa; Elvira Sondo; Federico Falchi; Nicoletta Pedemonte; Marinella Roberti; Andrea Cavalli

Original document: PMC | Score: 3.4632015 | Text size: 180864 | Find: similar documents

In a different proof-of-principle study, Buchner and co-workers showed that a drug-like small molecule could specifically interfere with the catalytic function of the cochaperone Aha1, without affecting complex formation with Hsp90 (Figure 9, panel 3).113 For that, they screened a library of ∼15,000 chemical compounds from ChemDiv by a FRET-based assay that monitored the interaction between Hsp90 and Aha1 and identified nearly 40 compounds as possible modulators.

STAT3 pathway in cancers: Past, present, and future

Han‐Qi Wang; Qi‐Wen Man; Fang‐Yi Huo; Xin Gao; Hao Lin; Su‐Ran Li; Jing Wang; Fu‐Chuan Su; Lulu Cai,; Yi Shi; Bing Liu,; Lin‐Lin Bu

PMC ID: PMC8942302 | DOI: 10.1002/mco2.124 | Journal: MedComm, 3(1) | Publisher: John Wiley and Sons Inc. | Publication date: 2022-03-23

Original document: PMC | Score: 4.4422913 | Text size: 144025 | Find: similar documents

Moreover, to prevent off‐target side effects, inS3‐54 analogs were searched in the virtual Chemdiv database, and analog A18 was demonstrated to specifically bind to the DBD of STAT3 and inhibit its activity.

A Set of Experimentally Validated Decoys for the Human CC Chemokine Receptor 7 (CCR7) Obtained by Virtual Screening

Matic Proj; Steven De Jonghe; Tom Van Loy; Marko Jukič; Anže Meden; Luka Ciber; Črtomir Podlipnik; Uroš Grošelj; Janez Konc; Dominique Schols; Stanislav Gobec

PMC ID: PMC8972196 | DOI: 10.3389/fphar.2022.855653 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-03-18

Original document: PMC | Score: 7.713231 | Text size: 54897 | Find: similar documents

The third library used for pharmacophore-based screening contained 1.1 million compounds based on curated diversity sets from Asinex, ChemBridge, ChemDiv, Enamine, KeyOrganics, and Pharmeks.

A novel HIF-2α targeted inhibitor suppresses hypoxia-induced breast cancer stemness via SOD2-mtROS-PDI/GPR78-UPRER axis

Yuanyuan Yan; Miao He; Lin Zhao; Huizhe Wu; Yanyun Zhao; Li Han; Binbin Wei; Dongman Ye; Xuemei Lv; Yan Wang; Weifan Yao; Haishan Zhao; Bo Chen; Zining Jin; Jian Wen; Yan Zhu; Tao Yu; Feng Jin; Minjie Wei

Original document: PMC | Score: 8.475872 | Text size: 93408 | Find: similar documents

Recombinant human SOD2 (Abcam, ab93946), Paclitaxel (Sigma, T7402), Doxorubicin, (Sigma, D1515), Mitoxantrone (Sigma, M2305000), Cisplatin (Sigma, P4394), Docetaxel (Sigma, 01885), Mito TEMPO (Sigma, SML0737), PDI inhibitor 16F16 (Sigma, SML0021), YQ-0629 (Topscience, chemdiv diversity discovery library), (3-Aminopropyl) triethoxysilane (sigma, A3648), Glutaraldehyde solution (sigma, G7651). ... The chemical library was from chemdiv diversity discovery library (Topscience Co., Ltd).

CpxA Phosphatase Inhibitor Activates CpxRA and Is a Potential Treatment for Uropathogenic Escherichia coli in a Murine Model of Infection

Kate R. Fortney; Sara N. Smith; Julia J. van Rensburg; Julie A. Brothwell; Jessi J. Gardner; Barry P. Katz; Nagib Ahsan; Adam S. Duerfeldt; Harry L. T. Mobley; Stanley M. Spinola; Bonnie Chase Prokesch

PMC ID: PMC9045377 | DOI: 10.1128/spectrum.02430-21 | Journal: Microbiology Spectrum, 10(1) | Publisher: American Society for Microbiology | Publication date: 2022-03-17

Original document: PMC | Score: 7.26731 | Text size: 59485 | Find: similar documents

Compounds 1 and 6 were purchased from ChemDiv and Aurum Pharmatech, respectively (31, 32).

Changes in Triple-Negative Breast Cancer Molecular Subtypes in Patients Without Pathologic Complete Response After Neoadjuvant Systemic Chemotherapy

Hiroko Masuda; Kenichi Harano; Sakiko Miura; Ying Wang; Yuko Hirota; Oi Harada; Mohit Kumar Jolly; Yuki Matsunaga; Bora Lim; Anita L. Wood; Napa Parinyanitikul; Hee Jin Lee; Gyungyub Gong; Jason T. George; Herbert Levine; Jangsoon Lee; Xiaoping Wang; Anthony Lucci; Arvind Rao; Brock L. Schweitzer; O. Rayne Lawrence; Robert S. Seitz; Stephan W. Morris; David R. Hout; Seigo Nakamura; Savitri Krishnamurthy; Naoto T. Ueno

PMC ID: PMC8939918 | DOI: 10.1200/PO.20.00368 | Journal: JCO Precision Oncology, 6(1) | Publisher: Wolters Kluwer Health | Publication date: 2022-03-16

Original document: PMC | Score: 12.167842 | Text size: 41233 | Find: similar documents

Jangsoon Lee Research Funding: AnHeart Therapeutics, CytoDyn, ChemDiv ... Jangsoon Lee Research Funding: AnHeart Therapeutics, CytoDyn, ChemDiv

Discovery of Novel HPK1 Inhibitors Through Structure-Based Virtual Screening

Huizhen Ge; Lizeng Peng; Zhou Sun; Huanxiang Liu; Yulin Shen; Xiaojun Yao

PMC ID: PMC8967249 | DOI: 10.3389/fphar.2022.850855 | Journal: Frontiers in Pharmacology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-03-14

Original document: PMC | Score: 13.700139 | Text size: 41700 | Find: similar documents

About 1.5 million molecules from the ChemDiv database (version 2019) were used for virtual screening. ... About 1.5 million molecules in the ChemDiv (version 2019) database were used as the screening source. ... In this study, the Glide docking-based virtual screening and kinase inhibition assay were conducted to discover HPK1 inhibitors from the ChemDiv database.

Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer

Yixiao Zhang; Lisha Sun; Haonan Li; Liping Ai; Qingtian Ma; Xinbo Qiao; Jie Yang; Hao Zhang; Xunyan Ou; Yining Wang; Guanglei Chen; Jinqi Xue; Xudong Zhu; Yu Zhao; Yongliang Yang; Caigang Liu; Renata Pasqualini; Mone Zaidi

PMC ID: PMC8937232 | DOI: 10.7554/eLife.68481 | Journal: eLife, 11(1) | Publisher: eLife Sciences Publications, Ltd | Publication date: 2022-03-14

Original document: PMC | Score: 9.797036 | Text size: 73390 | Find: similar documents

Chemdiv Compond, San Diego, CA ... The results showed that C67399 (C38H48O5, 584.79 Da, 4903–2135, Chemdiv Compond, San Diego, CA) could obviously inhibit the cell viability of MDA-MB-231 cells (Figure 5—figure supplement 1C).

An Overview of the Mechanisms Against “Candidatus Liberibacter asiaticus”: Virulence Targets, Citrus Defenses, and Microbiome

Chuanyu Yang; Veronica Ancona

PMC ID: PMC8982080 | DOI: 10.3389/fmicb.2022.850588 | Journal: Frontiers in Microbiology, 13(1) | Publisher: Frontiers Media S.A. | Publication date: 2022-03-10

Original document: PMC | Score: 9.42958 | Text size: 85779 | Find: similar documents

Bortezomib, Chemdiv C549-0604, and Chemdiv D244-0326 etc.

Complex of HIV-1 Integrase with Cellular Ku Protein: Interaction Interface and Search for Inhibitors

Ekaterina Ilgova; Simon Galkin; Maria Khrenova; Marina Serebryakova; Marina Gottikh; Andrey Anisenko; Nuno Taveira

PMC ID: PMC8951179 | DOI: 10.3390/ijms23062908 | Journal: International Journal of Molecular Sciences, 23(1) | Publisher: MDPI | Publication date: 2022-03-08

Original document: PMC | Score: 12.154662 | Text size: 65386 | Find: similar documents

To select such compounds, the representative Diversity Library containing 50,000 compounds with high diversity scoring (ChemDiv, Moscow, Russia) was used for docking into the Ku heterodimer pocket (PDB ID: 1JEQ). ... A total of 50,000 molecules from ChemDiv Diversity Library were selected for structure-based virtual screening against HIV-1 integrase putative binding site of Ku heterodimer. ... All compounds in ChemDiv diversity dataset were filtered for PAINS [58].

Geneticin shows selective antiviral activity against SARS-CoV-2 by targeting programmed −1 ribosomal frameshifting

Carmine Varricchio; Gregory Mathez; Laurent Kaiser; Caroline Tapparel; Andrea Brancale; Valeria Cagno

PMC ID: PMC8923105 | DOI: 10.1101/2022.03.08.483429 | Journal: bioRxiv | Publisher: Cold Spring Harbor Laboratory | Publication date: 2022-03-08

Original document: PMC | Score: 11.3442745 | Text size: 50145 | Find: similar documents

A library of commercially available RNA-targeting compounds was downloaded from Enamine and ChemDiv website. ... To test the druggability of the binding site, we screened an RNA targeted library (Enamine, ChemDIV), which contains 44520 commercially available RNA-binding compounds, against site

Structure-Based Discovery of N-Sulfonylpiperidine-3-Carboxamides as Novel Capsid Assembly Modulators for Potent Inhibition of HBV Replication

Yang Yang; Yu Yan; Jiaxin Yin; Jie Hu; Xuefei Cai; Jieli Hu; Jie Xia; Kai Wang; Ni Tang; Luyi Huang; Koichi Watashi

PMC ID: PMC8876525 | DOI: 10.3390/v14020348 | Journal: Viruses, 14(1) | Publisher: MDPI | Publication date: 2022-02-08

Original document: PMC | Score: 11.093979 | Text size: 54984 | Find: similar documents

Compounds for screening were obtained from Chemdiv Inc. ... Small molecules from ChemDiv and Vitas-M libraries were prepared using Open Babel [42] and were docked into the SBA binding site using AutoDock Vina [43].

Discovery of Chitin Deacetylase Inhibitors through Structure-Based Virtual Screening and Biological Assays

Yaodong Liu; Sibtain Ahmed; Yaowei Fang; Meng Chen; Jia An; Guang Yang; Xiaoyue Hou; Jing Lu; Qinwen Ye; Rongjun Zhu; Qitong Liu; Shu Liu

Original document: PMC | Score: 17.81079 | Text size: 35511 | Find: similar documents

In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening. ... In this study, the 3D structure of AnCDA (pdb code: 2Y8U) was applied as the most reliable docking structure and used to screen the ChemDiv library through the SBVS method. ... The top-ranked 30 compounds derived from the ChemDiv database by structure-based pharmacophore virtual screening were purchased from ChemDiv, Inc. ... Representative molecular properties and key parameters identified in docking-based VS of the 23 purchased compounds from ChemDiv database. ... The compound number labeled in the ChemDiv database. ... According to the purity statements, the purity of all compounds purchased from the ChemDiv database is higher than 95%.

Identification of novel SARS-CoV-2 RNA dependent RNA polymerase (RdRp) inhibitors: From in silico screening to experimentally validated inhibitory activity

Tanaporn Uengwetwanit; Nopporn Chutiwitoonchai; Kanin Wichapong; Nitsara Karoonuthaisiri

PMC ID: PMC8813674 | DOI: 10.1016/j.csbj.2022.02.001 | Journal: Computational and Structural Biotechnology Journal | Publisher: The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. | Publication date: 2022-02-04

Original document: PMC | Score: 13.953599 | Text size: 39315 | Find: similar documents

Molecular docking was employed to screen inhibitors of SARS-CoV-2 from the ZINC ChemDiv database. ... To discover candidate inhibitors that can bind SARS-CoV-2 RdRp, molecular docking was carried out to screen for potential hit compounds from the Zinc (purchasable ChemDiv library) which contain diverse scaffolds [26]. ... Compounds from the purchasable Zinc ChemDiv library were docked into the binding pocket of the SARS-CoV-2 RdRp structure to predict the binding affinity.

Discovery of a novel nonsteroidal selective glucocorticoid receptor modulator by virtual screening and bioassays

Jin-ping Pang; Xue-ping Hu; Yun-xia Wang; Jia-ning Liao; Xin Chai; Xu-wen Wang; Chao Shen; Jia-jia Wang; Lu-lu Zhang; Xin-yue Wang; Feng Zhu; Qin-jie Weng; Lei Xu; Ting-jun Hou; Dan Li

Original document: PMC | Score: 14.207614 | Text size: 52284 | Find: similar documents

By screening the ChemDiv chemical library, 54 potential compounds were identified and submitted to bioassays. ... Before molecule docking, the small molecules in the ChemDiv chemical library were prepared using the LigPrep module in Schrödinger, and filtered by the Lipinski’s rule-of-five [32] and Oprea’s [33] rules. ... We evaluated the toxicity of the compounds purchased from Chemdiv.

Comparative Characterization of CpCDPK1 and CpCDPK9, Two Potential Drug Targets against Cryptosporidiosis

Jiayuan Su; Yiting Shen; Na Li; Yu Li; Ziding Zhang; Lihua Xiao; Yaqiong Guo; Yaoyu Feng; Eric Viscogliosi; Gabriela Certad; Magali Chabé

PMC ID: PMC8875172 | DOI: 10.3390/microorganisms10020333 | Journal: Microorganisms, 10(1) | Publisher: MDPI | Publication date: 2022-02-01

Original document: PMC | Score: 8.217452 | Text size: 47108 | Find: similar documents

These small molecules were selected based on the factors of molecular weight, ligand efficiency, coulomb energy, and H-bond energy in molecular docking of CpCDPK1 and CpCDPK9 in the ChemDiv database.

GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic expression systems

Cristina V. Iancu; Giovanni Bocci; Mohd Ishtikhar; Moumita Khamrai; Mislav Oreb; Tudor I. Oprea; Jun-yong Choe

PMC ID: PMC8791944 | DOI: 10.1038/s41598-022-05383-9 | Journal: Scientific Reports, 12(1) | Publisher: Nature Publishing Group UK | Publication date: 2022-01-26

Original document: PMC | Score: 7.26731 | Text size: 62641 | Find: similar documents

He is on the Scientific Advisory Board of ChemDiv Inc. and Insilico Medicine.

Structure–Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors

Andrey A. Poloznikov; Sergey V. Nikulin; Dmitry M. Hushpulian; Anna Yu. Khristichenko; Andrey I. Osipyants; Andrey F. Asachenko; Olga V. Shurupova; Svyatoslav S. Savin; Sue H. Lee; Irina N. Gaisina; Gregory R. J. Thatcher; Anthony Narciso; Eric P. Chang; Sergey V. Kazakov; Nancy Krucher; Vladimir I. Tishkov; Bobby Thomas; Irina G. Gazaryan; Stanley Omaye

PMC ID: PMC8868400 | DOI: 10.3390/antiox11020220 | Journal: Antioxidants, 11(1) | Publisher: MDPI | Publication date: 2022-01-24

Original document: PMC | Score: 13.455724 | Text size: 47541 | Find: similar documents

Branched-tail oxyquinolines were purchased from ChemDiv (Moscow, Russia) or synthesized using the established protocol [9]; the minimum purity guaranteed by the supplier was 90%, and all purchased compounds were provided with NMR spectra. ... All compounds are commercially available from ChemDiv (Skolkovo, Russia). ... Other compounds are commercially available from ChemDiv (Skolkovo, Russia).

In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease

Muya Xiong; Tianqing Nie; Qiang Shao; Minjun Li; Haixia Su; Yechun Xu

Original document: PMC | Score: 13.953599 | Text size: 38116 | Find: similar documents

In this work, we collected covalent warheads observed among the known peptidomimetic inhibitors of the SARS-CoV-2 3CLpro and used them as reference to pick up the potential covalent binders from the list resulting from the virtual screening on ChemDiv database. ... Our protocol for in silico screening consisted of two stages: a large-scale non-covalent virtual screening of compounds from ChemDiv database, which was followed by a covalent docking of the compounds containing the warheads shown in Fig. 1 . ... ChemDiv ID

Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors

Arup R. Chakraborty; Alex Vassilev; Sushil K. Jaiswal; Constandina E. O'Connell; John F. Ahrens; Barbara S. Mallon; Martin F. Pera; Melvin L. DePamphilis

PMC ID: PMC8828683 | DOI: 10.1016/j.stemcr.2021.12.013 | Journal: Stem Cell Reports, 17(1) pp. 397-412 | Publisher: Elsevier | Publication date: 2022-01-20

Original document: PMC | Score: 7.26731 | Text size: 60240 | Find: similar documents

WX8 (Specs, ChemDiv), Apilimod (Selleck Chemicals), and Adriamycin (MilliporeSigma) were purchased.

Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern

Luca Murer; Romain Volle; Vardan Andriasyan; Anthony Petkidis; Alfonso Gomez-Gonzalez; Liliane Yang; Nicole Meili; Maarit Suomalainen; Michael Bauer; Daniela Sequeira; Dominik Olszewski; Fanny Georgi; Fabien Kuttler; Gerardo Turcatti; Urs F. Greber

PMC ID: PMC8760634 | DOI: 10.1016/j.crviro.2022.100019 | Journal: Current Research in Virological Science | Publisher: Published by Elsevier B.V. | Publication date: 2022-01-15

Original document: PMC | Score: 5.173614 | Text size: 106219 | Find: similar documents

The remaining compounds were purchased from abcr GmbH, AK Scientific, Inc., Abcam plc., Acros Organics, AdipoGen Life Sciences, Inc., Advanced ChemBlocks Inc., Alinda Chemical Trade Company Ltd., Angene, Apollo Scientific Ltd., Axon Medchem, BIOTREND Chemikalien GmbH, BLD Pharmatech Ltd., Biosynth Carbosynth, Cayman Chemical Company, ChemBridge Corporation, ChemDiv Inc., Chemodex Ltd., Cohesion Biosciences Ltd., Combi-Blocks, Inc., Enamine Ltd.

Maiia E. Bragina; Antoine Daina; Marta A. S. Perez; Olivier Michielin; Vincent Zoete; Bruno Pagano

PMC ID: PMC8776004 | DOI: 10.3390/ijms23020811 | Journal: International Journal of Molecular Sciences, 23(1) | Publisher: MDPI | Publication date: 2022-01-12

Original document: PMC | Score: 12.786698 | Text size: 36135 | Find: similar documents

Enamine, ChemBridge, Maybridge, Asinex, AsisChem, Otava, SPECS, TimTec, Vitas, Life Chemicals, ChemDiv, Innovapharm. ... In particular, on top of ZINC (drug-like, lead-like, and fragments), it is possible to screen compounds in the following commercially available chemical libraries: Enamine, ChemBridge, Maybridge, Asinex, AsisChem, Otava, SPECS, TimTec, Vitas, Life Chemicals, ChemDiv, and Innovapharm.

A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes‐Associated Breast Cancer

Qiongyu Hao; Zhimin Huang; Qun Li; Dingxie Liu; Piwen Wang; Kun Wang; Jieqing Li; Wei Cao; Wenhong Deng; Ke Wu; Rui Su; Zhongmin Liu; Jay Vadgama; Yong Wu

PMC ID: PMC8867195 | DOI: 10.1002/advs.202102303 | Journal: Advanced Science, 9(1) | Publisher: John Wiley and Sons Inc. | Publication date: 2022-01-12

Original document: PMC | Score: 11.3442745 | Text size: 50770 | Find: similar documents

A total of 237 (113 from enamine; 84 from chemdiv, 40 from Chembridge) potential hits were identified using the docking‐based virtual screening. ... We then virtually screened seven commercial compound libraries (ChemBridge, ChemDiv, Enamine, InterBioScreen, Life Chemicals, Maybridge and SPECS), including more than 5 million compounds, targeting the binding pocket.

COMPOSITIONS AND METHODS FOR TREATING, PREVENTING OR REVERSING AGE-ASSOCIATED INFLAMMATION AND DISORDERS

John M. SEDIVY [US]; Gerwald JOGL [US]; Alexandra D'ORDINE [US]

Publication date: 2023-05-04 | Patent publication No.: US-20230139684-A1 | Assignees: Brown University [US] | IPC: A61K31/4741; A61K31/198; A61K31/366; A61K31/145; A61K31/17; A61K31/4192; A61K31/445; A61K31/166; A61K31/167; A61K31/64; A61K31/4035; A61K31/505; A61K31/423; A61K31/381; A61K31/53; A61K31/635 | Oldest priority date: 2019-11-22 | Publication date: 2023-05-04

Score: 12.352504 | Text size: 114680 | Find: similar documents

Compounds were obtained from the following sources: AD1 (National Cancer Institute), AD2 (Alinda), AD3 (ChemBridge), AD4 (AK Scientific), AD5 (ChemDiv), AD6 (ChemBridge), AD7 (Enamine), AD8 (Sigma), AD9 (ChemDiv), AD10 (ChemBridge), AD11 (ChemDiv), AD12 (Sigma), AD13 (Specs), AD14 (Specs), AD15 (TargetMol), AD16 (Vitas), AD17 (Vitas), AD18 (UkrOrgSynthesis), AD19 (TimTec), AD20 (Vitas).

INHIBITORS OF VIRAL HELICASES BINDING TO A NOVEL ALLOSTERIC BINDING SITE

MENZER, William M. [DE]; KNOBLOCH, Gunnar [DE]; SCHOMBURG, Adrian [DE]; LIELEG, Corinna [DE]; SENNHENN, Peter [DE]

Publication date: 2023-05-04 | Patent publication No.: WO-2023073222-A1 | Assignees: EISBACH BIO GMBH [DE] | IPC: A61K31/4155; A61K31/433; A61K31/517; A61P31/12; C07D231/00 | Oldest priority date: 2021-10-29 | Publication date: 2023-05-04

Score: 4.3235645 | Text size: 213643 | Find: similar documents

All compounds that have been rationally designed as described in Example 1 were ordered from the manufacturers Enamine (Riga, Latvia), ChemDiv (San Diego CA, USA), or Intonation Research Laboratories (Hyderabad, India) under CDA as shown in the table in Fig. 20.

Pyrazoles

Rudolf Schindler [DE]; Hans-Joachim Lankau [DE]; Norbert Höfgen [DE]; Christian Grunwald [DE]; Ute Egerland [DE]; Barbara Langen [DE]; Rita Dost [DE]; Thorsten Hage [DE]; Simon Ward [GB]

Publication date: 2023-05-02 | Patent publication No.: US-RE049517-E1 | Assignees: JANSSEN PHARMACEUTICALS, INC. [US] | IPC: C07D231/12; A61K31/4155; A61K31/03; C07D403/06 | Oldest priority date: 2014-08-15 | Publication date: 2023-05-02

Score: 12.433797 | Text size: 179865 | Find: similar documents

4-(chloroethyl)-3,5-dimethyl-1H-pyrazole, available from ChemDiv, order ID: BB01-4360 ... 3-(chloromethyl)-1H-pyrazole hydrochloride, available from ChemDiv, order ID: BB20-2557 ... 4-(chloromethyl)-1-ethyl-1H-pyrazole hydrochloride, available from ChemDiv, order ID: BB57-1549 ... 5-(chloromethyl)-1-ethyl-1H-pyrazole hydrochloride, available from ChemDiv, order ID: BB57-3435 ... The reaction mixture was stirred at room temperature for 20 minutes, then 4-(2-chloro-ethyl)-3,5-dimethyl-1H-pyrazole (159 mg, 1.0 mmol) (ChemDiv, BB01-4360) was added.

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USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE

David J. Dowling [US]; Ofer Levy [US]; Francesco Borriello [US]; David A. Scott [US]; Spencer E. Brightman [US]

Publication date: 2023-04-27 | Patent publication No.: US-20230132397-A9 | Assignees: Children's Medical Center Corporation [US]; Dana-Farber Cancer Institute, Inc. [US] | IPC: A61K39/39; A61K45/06; A61K31/739; A61K31/4535; A61K31/381; A61K31/496; A61K31/438; A61K31/4025 | Oldest priority date: 2018-07-27 | Publication date: 2023-04-27

Score: 4.9277406 | Text size: 385657 | Find: similar documents

The chemical libraries screened included known bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... The chemical libraries screened included known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).

Small molecule antiviral drug treatment for human papillomavirus infections

Elliot J. Androphy [US]; Samy Meroueh [US]; Zhijian Lu [US]

Publication date: 2023-04-18 | Patent publication No.: US-11628158-B2 | Assignees: THE TRUSTEES OF INDIANA UNIVERSITY [US]; KOVINA THERAPEUTICS, INC. [US] | IPC: A61K31/381; A61P31/20; A61K9/00; C07D215/06; C07D487/04; C07D495/04; A61K38/10 | Oldest priority date: 2020-04-17 | Publication date: 2023-04-18

Score: 6.3513765 | Text size: 110204 | Find: similar documents

EIN-116(cat #V008-7329), EIN-117(cat #V008-7342), EIN-118(cat #V009-0689), EIN-119(cat #V009-0721), EIN-120(cat #V009-8145), EIN-121(cat #V013-5084), EIN-123(cat #V009-3346), EIN-124(cat #V001-3096), EIN-125(cat #V001-3172), EIN-126(cat #V002-4119), EIN-127(cat #V002-4126), EIN-128(cat #V002-4718), EIN-129(cat #V012-2359), EIN-130(cat #V031-2694), and EIN-131(cat #V031-2717) were each purchased from ChemDiv.

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Methods and pharmaceutical compositions for the treatment of diseases mediated by the NRP-1/OBR complex signaling pathway

Zakia Belaid-Choucair [FR]; Olivier Hermine [FR]; Carmen Garrido-Fleury [FR]; Claude Cochet [FR]; Odile Filhol-Cochet [FR]; Renaud Seigneuric [FR]

Publication date: 2023-04-18 | Patent publication No.: US-11629192-B2 | Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) [FR]; UNIVERSITÉ PARIS CITÉ [FR]; FONDATION IMAGINE [FR]; ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP) [FR]; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR]; UNIVERSITE GRENOBLE ALPES [FR]; COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES [FR]; UNIVERSITE DE BOURGOGNE [FR] | IPC: A61K31/00; A61K39/00; C07K16/28; A61K38/17; A61K31/4745; A61K31/7105; A61K31/713; A61K39/395; A61K45/06; C12N15/113; G01N33/566 | Oldest priority date: 2014-02-18 | Publication date: 2023-04-18

Score: 5.952544 | Text size: 141168 | Find: similar documents

Starting materials useful for preparing compounds of the invention and intermediates thereof are commercially available from sources, such as Aldrich Chemical Co. (Milwaukee, Wis.), Sigma Chemical Co. (St. Louis, Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (San Diego, Calif.), ChemDiv (San Diego, Calif.), SPECS (Delft, The Netherlands), Timtec (Newark, Del.), or alternatively can be prepared by well-known synthetic methods (see, e.g., Harrison et al., “Compendium of Synthetic Organic Methods”, Vols.

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TLR8 AGONIST FOR MODULATING IMMUNE RESPONSE

DOWLING, David, J. [US]; LEVY, Ofer [US]; VAN HAREN, Simon, D. [US]; CHEW, Katherine [US]; SONI, Dheeraj [US]; DE LEON, Maria [US]

Publication date: 2023-04-06 | Patent publication No.: WO-2023056337-A1 | Assignees: THE CHILDREN'S MEDICAL CENTER CORPORATION [US] | IPC: A61K31/4184; A01N43/52; A61P31/04; A61P35/00; C07D235/04; C07D235/20 | Oldest priority date: 2021-09-30 | Publication date: 2023-04-06

Score: 4.530187 | Text size: 212389 | Find: similar documents

These molecules originated from various bioactive and commercial libraries such as ChemDiv, ChemB ridge, and Asinex.

TLR4 AGONIST FOR MODULATING IMMUNE RESPONSE

LEVY, Ofer [US]; DOWLING, David, J. [US]; VAN HAREN, Simon, D. [US]; CHEW, Katherine [US]; SAITO, Yoshine [US]

Score: 4.530187 | Text size: 206951 | Find: similar documents

These molecules originated from various bioactive and commercial libraries such as ChemDiv, ChemBridge, and Asinex.

Identification of Stabilizers of Multimeric Proteins

Isabella A. Graef [US]; Mamoun M. Alhamadsheh [US]

Publication date: 2023-04-06 | Patent publication No.: US-20230105307-A1 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/12; A61K31/4196; A61K31/428; A61K31/433; C07D231/12; C07D487/04; A61K31/519; A61K31/166 | Oldest priority date: 2010-05-07 | Publication date: 2023-04-06

Score: 5.952544 | Text size: 136723 | Find: similar documents

Approximately 120,000 compounds from the Stanford HTBC library were screened (Diverse compounds form Chemdiv, Chembridge, SPECS. and LOPAC1280-1280 compounds Library of Pharmacologically Active Compounds from Sigma).

PHARMACEUTICAL COMPOSITIONS FOR USE IN PREVENTION AND/OR TREATMENT AND/OR CURE OF HEPATITIS B VIRUS

The designation of the inventor has not yet been filed

Score: 12.252368 | Text size: 69943 | Find: similar documents

An additional compound library consisting of 556 analogues was purchased from ChemDiv Inc. ... The inhibitory potential of all compounds of the Spectrum Collection (n = 2000) and the ChemDiv library (n = 556) were determined at equimolar concentrations with 3 μM tauro-nor-THCA-24-DBD.

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MYCOBACTERIUM ABSCESSUS GROWTH INHIBITOR AND MODEL

GRÜBER, Gerhard [SG]; SHIN, Joon [SG]; AMARAVADHI, Venkata Krishna Harikishore [SG]; WONG, Chui Fann [SG]; RAGUNATHAN, Priya [SG]

Publication date: 2023-03-30 | Patent publication No.: WO-2023048641-A2 | Assignees: NANYANG TECHNOLOGICAL UNIVERSITY [SG] | Oldest priority date: 2021-09-21 | Publication date: 2023-03-30

Score: 10.849978 | Text size: 88143 | Find: similar documents

ChemDiv vendor library was employed using the default settings in Phase ligand preparation (Schrodinger release (2020-4) phase. New York, NY: Schrodinger, LLC; 2019; and Dixon, S. L. et al., J. Comput. ... Database screening with this pharmacophore model yielded about 30,000 molecules from the 1.3 million ChemDiv commercial library (San Diego, CA, USA) for further virtual screening studies.

NON-FIBRILLAR HEMOGLOBIN S OLIGOMERS AND METHODS TO IDENTIFY MODULATORS OF HEMOGLOBIN S POLYMERIZATION

David Kevin Wood [US]; Jonathan N. Sachs [US]; Nagamani Vunnam [US]; Chih Hung Lo [SG]

Score: 7.9492164 | Text size: 80817 | Find: similar documents

Small molecule libraries are available, and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library, LOPAC 1280TH, MicroSource Spectrum Collection, Pharmakon, The Prestwick Chemical Library®, SPECS, NIH Clinical Collection, Chiral Centers Diversity Library.

PURMORPHAMINE AS A SMALL COMPOUND POSITIVE ALLOSTERIC MODULATOR OF SECRETIN RECEPTOR FOR THE TREATMENT OF HYPERTENSION

Kailash SINGH [CN]; Billy Kwok Chong CHOW [CN]

Score: 10.262654 | Text size: 113338 | Find: similar documents

Publicly available small molecule libraries used include, but not limited to, PubChem, CHEMBL, MolProt, ChemDiv, ChemSpace, NCI open and ZINC. ... Hits from both the pharmacophore searches were combined together and a total of 1,03,555 small compounds were selected as hits (CHEMBL-11010hits; ChemDiv-330 hits; ChemSpace-8173, Molprot-5,163 hits; NCI open-422; PubChem-71,630; ZINC-6,827) via Pharmit tools.

COMPOUND FOR PREVENTING OR TREATING LIPID METABOLISM-RELATED DISEASES

LU, Boxun [CN]; FU, Yuhua [CN]; DING, Yu [CN]

Publication date: 2023-03-29 | Patent publication No.: EP-4155294-A1 | Assignees: Fudan University [CN] | IPC: C07D209/34; C07D403/06; C07D311/16; C07D239/88; C07D403/12; C07D487/04; C07D401/12; C07D513/04; C07D409/14; C07D239/70; C07J9/00; A61P3/00; A61P3/04; A61P3/10; A61P1/16; A61P35/00; A61P9/10; A61P25/28; A61K31/352; A61K31/404 | Oldest priority date: 2020-04-23 | Publication date: 2023-03-29

Score: 6.047818 | Text size: 409246 | Find: similar documents

Compound A4: commercially purchased from ChemDiv, CAS No. 779-27-1; ... Compound A5: also numbered AN2, PubChem CID 5398649, commercially purchased from ChemDiv, catalog number D715-2435; ... Compound A7: commercially purchased from ChemDiv;

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SMALL MOLECULE INHIBITORS OF VOLTAGE-GATED SODIUM CHANNEL 1.7 AND METHODS OF USING SAME

Andrey BORTSOV [US]; Sharat CHANDRA [US]; Ru-Rong JI [US]

Score: 14.708862 | Text size: 132748 | Find: similar documents

For virtual screening, a database of 1.5 million compounds was downloaded from the Chemdiv website (chemdiv.com, ChemDiv Inc., San Diego, Calif.). ... A similarity threshold value of 0.5 against the compounds from the Chemdiv database was used to screen for potential Nav1.7 inhibitors. ... Similarity search of the ChemDiv database (ChemDiv Inc, San Diego, Calif.) containing 1.5 million pre-synthetized compounds yielded a set of 2000 compounds structurally similar to the query molecules—known inhibitors of Nav1.7. ... Of those, 9 compounds with unique scaffolds and sufficient quantity (1 mg or more) available in stock were selected and purchased from ChemDiv for in vitro and in vivo activity assessment.

COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY

Nigel RAMSDEN [GB]; David John FOX [GB]; James Andrew HUNTINGTON [GB]; James Michael TOMLINSON [GB]

Publication date: 2023-03-23 | Patent publication No.: US-20230089087-A1 | Assignees: Z Factor Limited [GB] | IPC: A61K31/451; A61K31/4709; A61K31/4015; A61P1/16; A61P11/00 | Oldest priority date: 2019-12-13 | Publication date: 2023-03-23

Score: 10.621242 | Text size: 39504 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

Leucine-Rich Repeat Kinase 2 Allosteric Modulators

Wim Versées [BE]; Ranjan Kumar Singh [BE]; Arjan Kortholt [NL]; Christian-Johannes Gloeckner [DE]

Publication date: 2023-03-23 | Patent publication No.: US-20230087785-A1 | Assignees: VIB VZW [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE]; RIJKSUNIVERSITEIT GRONINGEN [NL]; DEUTSCHES ZENTRUM FÜR NEURODEGENERATIVE ERKRANKUNGEN E.V. [DE] | IPC: C07K16/40; G01N33/68 | Oldest priority date: 2020-02-25 | Publication date: 2023-03-23

Score: 4.3235645 | Text size: 232358 | Find: similar documents

Synthetic compound libraries are commercially available from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ. of California).

INHIBITORS OF HSP70 PROTEINS

Eli Chapman [US]; Andrew J. Ambrose [US]; Taoda Shi [US]

Publication date: 2023-03-23 | Patent publication No.: US-20230091297-A1 | Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US] | IPC: A61K31/426; A61K31/427; A61K31/428; A61P35/00 | Oldest priority date: 2020-03-13 | Publication date: 2023-03-23

Score: 6.3513765 | Text size: 120208 | Find: similar documents

Compound 1, N-(3-methyl-1-oxo-1-(thiazol-2-ylamino)butan-2-yl)thiophene-2-carboxamide, was purchased from ChemDIV Inc.

INHIBITORS OF ANOCTAMIN 6 PROTEIN AND USES THEREOF

Jinah JEONG [KR]; Hyunjung KWAK [KR]; Gunhee KIM [KR]; Jeongeun KIM [KR]; Sanghwan LEE [KR]; Seolhee LEE [KR]; Jinhee LEE [KR]; Jihye CHOI [KR]; Hongchul YOON [KR]; Joontae PARK [KR]; Kyungmi AN [KR]; Jungwoo LEE [KR]; Eunjung LEE [KR]

Publication date: 2023-03-16 | Patent publication No.: US-20230080054-A1 | Assignees: ILDONG PHARMACEUTICAL CO., LTD. [KR] | IPC: C07D405/12; C07D307/52; C07D405/14; C07D237/20; C07D401/12; C07D403/12; C07D409/12; C07C237/30; C07D241/20; C07D239/42; C07D413/14; C07D409/14; C07D471/08; C07D213/74; C07D417/12; C07D271/07; C07D213/38; C07D239/26; C07D241/12; C07D211/98 | Oldest priority date: 2021-01-22 | Publication date: 2023-03-16

Score: 19.20178 | Text size: 404586 | Find: similar documents

Chemdiv, Inc ... ChemDiv, Inc. ... ChemDiv, Inc. ... ChemDiv, Inc. ...

COMPOSITIONS AND APPLICATIONS THEREOF

Todor A. Popov [BG]; Peter David Josling [GB]

Publication date: 2023-03-09 | Patent publication No.: US-20230075885-A1 | Assignees: Nasaleze Patents Limited [GB] | IPC: A61K9/16; A61K47/46; A61K31/675; A61K31/352; A61K41/00; A61K38/21; A61K31/215; A61K31/7056; A61K31/513; A61K36/16; A61K31/07; A61K31/375; A61K31/355; A61K36/258; A61K36/82; A61K31/522; A61K31/122; A61K36/23 | Oldest priority date: 2020-02-12 | Publication date: 2023-03-09

Score: 12.913415 | Text size: 93700 | Find: similar documents

A compound that shows potential for use against coronaviruses in general is K22, structural name (Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl) benzamide, available from ChemDiv (San Diego, Calif.: catalog number 4295-0370). ... A compound that shows potential for use against coronaviruses in general is K22, structural name (Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl)benzamide, available from ChemDiv (San Diego, Calif.: catalog number 4295-0370). ... A compound that shows potential for use against coronaviruses in general is K22, structural name (Z)-N-(3-(4-(4-bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl)benzamide, available from ChemDiv (San Diego, Calif.: catalog number 4295-0370).

DIRECT REPROGRAMMING OF SOMATIC CELLS INTO MYOGENIC CELLS

Konrad HOCHEDLINGER [US]; Ori BAR-NUR [US]

Publication date: 2023-02-09 | Patent publication No.: US-20230042917-A1 | Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC: C12N5/077; C12N15/85; C12Q1/6883; A61K35/34 | Oldest priority date: 2016-04-06 | Publication date: 2023-02-09

Score: 5.2883806 | Text size: 164100 | Find: similar documents

Compound libraries can be obtained commercially, for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

Compositions and methods of treatment using nicotinamide mononucleotide

Shin-ichiro Imai [US]; Alessia Grozio [US]

Publication date: 2023-01-31 | Patent publication No.: US-11564936-B2 | Assignees: Washington University [US] | IPC: A61K31/706; A61P3/04; A61K45/06; A61K48/00; C12N15/86; G01N33/50; G01N33/68 | Oldest priority date: 2017-08-10 | Publication date: 2023-01-31

Score: 5.2883806 | Text size: 156540 | Find: similar documents

For experiments with Sirt1 and Sirt6 inhibitors, the ilea from 24-month-old female B6 mice were pre-incubated for 2 h at 37° C. in 500 μl of secretion media contending 0.2% DMSO (vehicle), 20 M EX527 (Cayman chemical, MI) or 20 M STK665401 (ChemDiv, cat #8018-9378; Sociali, G. et al., Eur. J. Med.

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METHODS FOR IDENTIFYING ADAR1 INHIBITORS, AND COMPOSITIONS AND METHODS OF USE IN TREATING CANCER

NISHIKURA, Kazuko [US]

Score: 4.530187 | Text size: 202787 | Find: similar documents

It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.), Fluka Chemika-Biochemica-Analytika (Buchs Switzerland) and the like.

METHODS FOR IDENTIFYING ADAR1 INHIBITORS, AND COMPOSITIONS AND METHODS OF USE IN TREATING CANCER

NISHIKURA, Kazuko [US]

Score: 4.530187 | Text size: 202941 | Find: similar documents

CRYSTAL STRUCTURES OF ALK AND LTK RECEPTOR TYROSINE KINASES AND THEIR LIGANDS

SAVVIDES, Savvas [BE]; DE MUNCK, Steven [BE]

Publication date: 2023-01-12 | Patent publication No.: WO-2023280766-A1 | Assignees: VIB VZW [BE]; UNIVERSITEIT GENT [BE] | IPC: C12N9/12; C07K16/40; C07K14/52; C07K14/715; C30B29/58; G16B15/30 | Oldest priority date: 2021-07-07 | Publication date: 2023-01-12

Score: 6.3513765 | Text size: 123298 | Find: similar documents

ALDH3A2 INHIBITION AND FERROPTOSIS INDUCTION FOR CANCER THERAPY

Rushdia Yusuf [US]; Shrikanta Chattopadhyay [US]; David T. Scadden [US]; Nick Van Gastel [BE]; Azeem S. Sharda [US]; Borja Saez [ES]; Vasanthi S. Viswanathan [US]

Publication date: 2023-01-05 | Patent publication No.: US-20230000896-A1 | Assignees: Rushdia Yusuf [US]; Shrikanta Chattopadhyay [US]; President and Fellows of Harvard College [US]; The Broad Institute, Inc. [US]; The General Hospital Corporation [US] | IPC: A61K31/713; A61P35/00; A61K31/381; A61K31/437; A61K31/496 | Oldest priority date: 2019-12-09 | Publication date: 2023-01-05

Score: 4.530187 | Text size: 205906 | Find: similar documents

The initial screen will be performed on the ChemDiv 6 library, a select set of 44,000 public domain compounds.

TUMOR NECROSIS FACTOR ALPHA (TNF-ALPHA) SMALL MOLECULE INHIBITOR

Sang Dun CHOI [KR]; Mahesh Chandra PATRA [KR]; Nasir JAVAID [KR]; Maria BATOOL [KR]; Dae-Hyun HAHM [KR]

Publication date: 2023-01-05 | Patent publication No.: US-20230000861-A1 | Assignees: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]; UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY [KR] | IPC: A61K31/502; A61P29/00; A61P37/00; C07D417/14; C07D417/12 | Oldest priority date: 2019-11-05 | Publication date: 2023-01-05

Score: 11.169593 | Text size: 89229 | Find: similar documents

SPD304 (MolPort ID: MolPort-042-665-817; ChemDiv catalog #4031-0592), C87 (Tocris Cookson, Bristol, UK), rhTNF-α (Miltenyi Biotec, Auburn, Calif., USA), rhTNF-α (Miltenyi Biotec), act-D (Thermo Fisher Scientific, Inc.), and BS3 (Thermo Fisher Scientific, Inc.) were purchased from the respective companies, noted in parentheses above. ... ChemDiv

COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY

RAMSDEN, Nigel [GB]; FOX, David John [GB]

Score: 13.446067 | Text size: 15363 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

COMPOSITIONS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY

RAMSDEN, Nigel [GB]; FOX, David John [GB]; HUNTINGTON, James Andrew [GB]

Score: 10.057776 | Text size: 43695 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY

RAMSDEN, Nigel [GB]; FOX, David John [GB]

Publication date: 2022-12-22 | Patent publication No.: WO-2022263820-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: A61P1/16; A61P11/00; A61P35/00; C07D241/04; C07D265/30; A61K31/495; A61K31/5375 | Oldest priority date: 2021-06-15 | Publication date: 2022-12-22

Score: 12.766966 | Text size: 19482 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

COMPOUNDS AND THEIR USE FOR THE TREATMENT OF ALPHA1-ANTITRYPSIN DEFICIENCY

RAMSDEN, Nigel [GB]; FOX, David John [GB]

Score: 13.446067 | Text size: 14861 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

E3 LIGASE INHIBITORS AND METHODS OF USE THEREOF

RAPE, Michael [US]; SCHALETZKY, Julia Sabine [US]; WEHRI, Edward Eric [US]; MANFORD, Andrew Garrett [US]

Publication date: 2022-12-22 | Patent publication No.: WO-2022266321-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/42; A61K31/4164; A61P35/00; A61K31/423; A61K31/4709 | Oldest priority date: 2021-06-17 | Publication date: 2022-12-22

Score: 7.061031 | Text size: 104533 | Find: similar documents

Diversity and Antibacterial chemical libraries containing 100,000 and 15,000 small molecule compounds, respectively, were purchased from (Chemdiv, San Diego, CA) with same storage conditions.

RIG-I INNATE IMMUNE RECEPTOR ANTAGONISTS AND METHODS OF USING SAME

Anna Marie Pyle [US]; David Rawling [US]; Erik G. Jagdmann [US]; Olga Potapova [US]

Score: 6.3513765 | Text size: 123176 | Find: similar documents

Using this assay, a library of over 11,000 compounds spanning 11 libraries, including the ChemBridge, Enzo Kinase Inhibitor, Enzo Phosphatase Inhibitor, ChemDiv and Nuclear Receptor Libraries, was screened.

SMALL MOLECULE ACTIVATORS OF INTERFERON REGULATORY FACTOR 3 AND METHODS OF USE THEREOF

Susan Stevens [US]; Mary Stenzel-Poore [US]; Marie Foss [US]; Aaron Nilsen [US]; Haihong Jin [US]

Publication date: 2022-12-15 | Patent publication No.: US-20220395500-A1 | Assignees: Neuralexo, Inc. [US] | IPC: A61K31/496; A61P9/10; A61K31/167; A61K31/519; A61K31/5377; A61K31/341; A61K31/381; A61K31/423; A61K31/428; A61K31/427; A61K31/4365; A61K31/437; A61K31/4439; A61K31/4245; A61K31/4178; A61K31/55 | Oldest priority date: 2020-05-04 | Publication date: 2022-12-15

Score: 3.3945959 | Text size: 288502 | Find: similar documents

This library was purchased from SIGA Technologies in 2014 and is made up of compounds from the ChemBridge DIVERSetTM-CL library, the ChemBridge CORE Library, and two focused antiviral libraries from Life Chemicals and ChemDiv.

COMPOUNDS THAT BIND NON-CANONICAL G-QUADRUPLEX STRUCTURES AND METHODS OF MAKING AND USING THE SAME

SCHNEEKLOTH, John S. [US]; YANG, Mo [US]; LIANG, Xiao [US]; FULLENKAMP, Christopher [US]

Publication date: 2022-12-15 | Patent publication No.: WO-2022261296-A1 | Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US] | IPC: C07D413/04; C07D413/14; A61P35/00; A61K31/501 | Oldest priority date: 2021-06-09 | Publication date: 2022-12-15

Score: 8.120042 | Text size: 273393 | Find: similar documents

Other sequences of DNA/RNA samples used for binding specificity study are summarized in FIGS.1-2: Hit compounds for binding validation were purchased from ChemDiv and Chembridge. ... In these examples, compounds for SAR study were either purchased from ChemDiv (MY-1, MY-2, MY-3, MY-4, MY-9, MY-10, MY-11, MY-12) or synthesized in the lab (MY-5, MY-6, MY-7, MY-8, MY-13, MY-14). ... Briefly, ~15,000 compounds (10 mM in DMSO) from ChemDiv and Chembridge libraries as well as control dyes (Alexa Fluor 647 and 488, 10 μM in DMSO) were prepared in 384 well plates (Arrayjet JetstarTM).

INTEGRATED DRUG DISCOVERY PLATFORM FOR PROTEIN MISFOLDING DISORDERS ASSOCIATED WITH METABOLITE ACCUMULATION

Ehud GAZIT [IL]; Dana LAOR [IL]; Dorin SADE YAZDI [IL]

Score: 3.3945959 | Text size: 318328 | Find: similar documents

Compound libraries are commercially available from a number of companies including but not limited to Maybridge Chemical Co. (Trevillet, Cornwall, UK), Comgenex (Princeton, N.J.), Microsource (New Milford, Conn.), Aldrich (Milwaukee, Wis.), AKos Consulting and Solutions GmbH (Basel, Switzerland), Ambinter (Paris, France), Asinex (Moscow, Russia), Aurora (Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.), Chemical Block Lt, (Moscow, Russia).

PHARMACEUTICAL COMPOSITION FOR TREATING THYROID CANCER COMPRISING TYROSINE KINASE ACTIVITY INHIBITOR AS ACTIVE INGREDIENT

Byeong Cheol AHN [KR]; Ji Min OH [KR]

Publication date: 2022-12-01 | Patent publication No.: US-20220378796-A1 | Assignees: Kyungpook National University Industry-Academic Cooperation Foundation [KR] | IPC: A61K31/519; A61P35/04 | Oldest priority date: 2017-10-20 | Publication date: 2022-12-01

Score: 10.621242 | Text size: 41046 | Find: similar documents

Among the TKI candidates, TKI-0266 was selected, purchased from Chemdiv (USA), dissolved in DMSO, and then stored at −80° C.

COMPOSITIONS AND METHODS FOR SUPPRESSING AND/OR TREATING NEURODEGENERATIVE DISEASES AND/OR A CLINICAL CONDITION THEREOF

Kang-Yell CHOI [KR]; Minguen YOON [KR]; Soung-Hoon LEE [KR]

Score: 10.548147 | Text size: 102776 | Find: similar documents

To initially identify small molecules that inhibited the CXXC5-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described. ... 2280 compounds assayed in 96-well plates as single compounds at 10 mM in DMSO Small molecules ChemDiv and Sigma LOPAC 1280

WEED CONTROL METHOD

WHITTINGHAM, William Guy [GB]; SCUTT, James Nicholas [GB]; HENNESSY, Alan Joseph [GB]; FRYE, Elizabeth Catherine [GB]; DALE, Suzanna [GB]; ASPINALL, Ian Henry [GB]

Score: 7.061031 | Text size: 97018 | Find: similar documents

1-186, 1-6, 1-2 and 1-473 are obtainable as of the priority date of the present application from commercial sources, such as Enamine, Accela and ChemDiv.

SELECTIVE BROMODOMAIN INHIBITION OF FUNGAL BDF1

MCKENNA, Charles E. [US]; PETOSA, Carlo [FR]; GOVIN, Jerome [FR]; KASHEMIROV, Boris A. [US]; FERRI, Elena [US]; MIETTON, Flore [FR]

Publication date: 2022-11-23 | Patent publication No.: EP-3490552-B1 | Assignees: University of Southern California [US]; CNRS [FR]; Université Grenoble Alpes [FR]; Inserm [FR]; Commissariat à l'Energie Atomique et aux Energies Alternatives [FR] | IPC: A61K31/554; A61K31/437; A61K31/454; C07D281/14; C07D417/12; C07D417/14; C07D471/04; C07D513/04; A61P31/10 | Oldest priority date: 2016-07-26 | Publication date: 2022-11-23

Score: 13.495927 | Text size: 145215 | Find: similar documents

DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; chemcats: ChemDiv Inc: XP002799331, Database accession no. 1358915-86-2 ... DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2 March 2002 (2002-03-02), chemcats: ChemDiv Inco: "7-(5-(3-furanyl)-1,2,4-oxadiazol-3-yl)10- (1-methylethyl)-dibenzo(b,f)(1,4)thiazepin e-11(10H)-one", XP002799332, Database accession no. 1359492-68-4 ... DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2 March 2002 (2002-03-02), chemcats: chemdiv inc: "N-(10-cyclopropyl-10,11,dihydro-11-oxodib enzo[b,f][1,4]thiazepin-7-yl)-2-pyridineca rboxamide", XP002799334, Database accession no. 1359492-28-6

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Anti-cancer compounds targeting Ral GTPases and methods of using the same

Dan Theodorescu [US]; Michael Fitzpatrick Wempe [US]; David Ross [US]; Chao Yan [US]; Phillip Reigan [US]

Publication date: 2022-10-18 | Patent publication No.: US-11472812-B2 | Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US] | IPC: C07D491/052; A61K31/4162; A61P35/04; A61K45/06 | Oldest priority date: 2014-07-10 | Publication date: 2022-10-18

Score: 5.0089407 | Text size: 164417 | Find: similar documents

The ChemDiv library [v2006.5, 500,000 compounds excluding those possessing reactive groups, known ADME/toxicity, physicochemical properties lie outside drug-likeness' parameters (Lipinski's rule of 5 and Veber's Rule of 2) at pH 7] was downloaded from ZINC database and docked into the identified site on RalA-GDP using rigid docking protocols.

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Autophagy modulators for use in treating cancer

Melvin L. DePamphilis [US]; Gaurav Sharma [IN]; Juan Jose Marugan [US]; Marc Ferrer [US]; Ajit Roy [US]

Publication date: 2022-10-18 | Patent publication No.: US-11471460-B2 | Assignees: The United States of Americans represented by the Secretary, Department of Health and Human Services [US] | IPC: A61K31/53; A61P35/00; A61K31/506; C07D239/50; C07D251/54; C07D403/12 | Oldest priority date: 2017-12-01 | Publication date: 2022-10-18

Score: 5.952544 | Text size: 133677 | Find: similar documents

Compounds 1, 4, 5, 3, and 2 (Specs, ChemDiv, Life Chemicals) and Rapamycin (S1039, Selleck Chemicals) were dissolved in dimethyl sulfoxide (DMSO) at 20 mM concentrations and stored at −20° C. Compound 1 family compounds (FIG. 1) were assayed for purity by high pressure liquid chromatography and their identity confirmed by Mass spectroscopy.

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NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF

Catherine TACHDJIAN [US]; Andrew P. PATRON [US]; Sara L. ADAMSKI-WERNER [US]; Farid BAKIR [US]; Qing CHEN [US]; Vincent DARMOHUSODO [US]; Stephen Terrence HOBSON [US]; Xiaodong LI [US]; Ming QI [CN]; Daniel H. ROGERS [US]; Marketa RINNOVA [US]; Guy SERVANT [US]; Xiao-Qing TANG [US]; Mark ZOLLER [US]; David WALLACE [US]; Amy XING [US]; Klaus GUBERNATOR [US]

Publication date: 2022-10-13 | Patent publication No.: US-20220326230-A1 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; C07C233/65; C07C235/54; C07C275/30; C07C275/34; C07D307/84; C07D317/68; G01N33/566; G01N33/74; A23L27/20; C07D263/56; C07D213/81; C07D213/85; C07D215/48; C07D217/06; C07D231/14; C07D333/24; C07D333/38; C07D401/04; C07D409/12; C07D417/12; C07D261/18; C07D271/12; C07D275/03; C07D209/08; C07D277/64; C07D209/42; C07D285/135; C07D213/40; C07D307/52; C07D307/68; C07D307/79; C07D307/82; G01N33/50; A23L2/56; A61K8/49; A61K8/55; A61K47/22; A61K47/24; C07D405/12; C07F9/655; A23L27/00 | Oldest priority date: 2003-08-06 | Publication date: 2022-10-13

Score: 2.9692738 | Text size: 326033 | Find: similar documents

USA and their subsidiaries Fluka and Riedel-de Haën, at their various other worldwide offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego Calif., Chembridge of San Diego Calif., Asinex of Moscow Russia, SPECS/BIOSPECS of the Netherlands, Maybridge of Cornwall England, Acros, TimTec of Russia, Comgenex of South San Francisco Calif. and ASDI Biosciences of Newark Del.

CO-POTENTIATORS FOR THERAPY OF CYSTIC FIBROSIS CAUSED BY MINIMAL FUNCTION CFTR MUTANTS

Alan S. VERKMAN [US]; Puay-Wah PHUAN [US]; Peter M. HAGGIE [US]

Publication date: 2022-10-13 | Patent publication No.: US-20220323425-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/438; A61K31/47; A61K45/06; A61K31/4245 | Oldest priority date: 2019-08-28 | Publication date: 2022-10-13

Score: 7.629327 | Text size: 87877 | Find: similar documents

For screening, 120,000 diverse drug-like synthetic compounds (i.e., Structures (A), (B), (C), and (D); ChemDiv Inc., San Diego, Calif.) were tested.

CFTR REGULATORS AND METHODS OF USE THEREOF

VERKMAN, Alan [US]; LEVIN, Marc, H [US]; CIL, Onur [US]; KURTH, Mark, J [US]

Publication date: 2022-10-12 | Patent publication No.: EP-4071140-A1 | Assignees: The Regents of the University of California [US] | IPC: C07D241/44; A61K31/502; A61P11/00; A61P27/02 | Oldest priority date: 2016-08-18 | Publication date: 2022-10-12

Score: 6.2266536 | Text size: 717013 | Find: similar documents

High-throughput screening was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. ... For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... High-throughput screening was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. ... For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... Commercial analogs were purchased from ChemDiv (San Diego, CA).

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NOVEL SULFONAMIDE SERIES OF QR2 INHIBITORS TO TACKLE OXIDATIVE STRESS AND COGNITIVE DECLINE

ROSENBLUM, Kobi [IL]; GOULD, Natheniel [IL]; EDRI, Efrat [IL]

Publication date: 2022-10-06 | Patent publication No.: WO-2022208499-A1 | Assignees: CARMEL HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. [IL] | IPC: A61K31/40; C07D403/12; A61P25/00 | Oldest priority date: 2021-03-30 | Publication date: 2022-10-06

Score: 4.3235645 | Text size: 209193 | Find: similar documents

The chemical libraries used were Selleck Chemicals Bioactives, the Drug-like set from Enamine, HitFinder collection from Maybridge, Spectrum Collection from Microsource, Lopac from Sigma- Aldrich and the diversity sets from ChemDiv and ChemBridge.

TARGETING MELANOCORTIN 3 RECEPTOR FOR TREATMENT/PREVENTION OF EATING, METABOLISM, AND/OR EMOTIONAL DISORDERS

Roger Cone [US]; Patrick Sweeney [US]

Publication date: 2022-10-06 | Patent publication No.: US-20220313789-A1 | Assignees: The Regents of the University of Michigan [US] | IPC: A61K38/34; A61K38/26; A61K31/485; A61K45/06; A61P25/24; A61P3/04 | Oldest priority date: 2019-06-19 | Publication date: 2022-10-06

Score: 5.2883806 | Text size: 165300 | Find: similar documents

A screen was performed with a series of 4160 samples from the ChemDiv 100,000 compound diversity set maintained at CCG (FIG. 2D-F).

COMPOSITIONS COMPRISING RARE GENETIC SEQUENCE VARIANTS ASSOCIATED WITH PULMONARY FUNCTION AND METHODS OF USE THEREOF FOR DIAGNOSIS AND TREATMENT OF ASTHMA IN AFRICAN AMERICAN PATIENTS

Hakon Hakonarson [US]; Patrick Sleiman [US]

Publication date: 2022-10-06 | Patent publication No.: US-20220316008-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6883; A61P11/06; A61K31/5585; A61K31/135 | Oldest priority date: 2019-09-09 | Publication date: 2022-10-06

Score: 7.9492164 | Text size: 85748 | Find: similar documents

In addition, compound libraries are commercially available from a number of companies including but not limited to Maybridge Chemical Co. (Trevillet, Cornwall, UK), Comgenex (Princeton, N.J.), Microsource (New Milford, Conn.), Aldrich (Milwaukee, Wis.), AKos Consulting and Solutions GmbH (Basel, Switzerland), Ambinter (Paris, France), Asinex (Moscow, Russia), Aurora (Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive Chemistry, Ltd (Obninsk, Russia), Enamine (Kiev, Ukraine), Evotec (Hamburg, Germany), Indofine (Hillsborough, N.J.), Interbioscreen (Moscow, Russia), Interchim (Montlucon, France), Life Chemicals, Inc.

Autotaxin inhibitory compounds

Martin Lee Stockley [GB]; Ellen Catherine Macdonald [GB]; Pritom Shah [GB]; Allan Jordan [GB]; James Hitchin [GB]; Niall Hamilton [GB]

Publication date: 2022-09-27 | Patent publication No.: US-11453666-B2 | Assignees: Cancer Research Technology Limited [GB] | IPC: A61P1/00; A61P1/16; A61P29/00; A61P31/20; A61P31/14; A61P31/12; A61P3/10; A61P7/12; A61P17/00; A61P17/04; A61P17/02; A61P35/00; A61P35/02; A61P7/04; A61P7/02; A61P13/02; A61P13/12; A61P9/12; A61P9/00; A61P43/00; A61P19/04; A61K31/5025; A61K31/444; A61K31/4545; A61K31/5377; A61K31/404; A61K31/551; A61K31/55; A61K31/496; A61K31/4184; A61K45/06; C07D235/02; C07D471/04; A61K31/437 | Oldest priority date: 2015-02-06 | Publication date: 2022-09-27

Score: 6.047818 | Text size: 397678 | Find: similar documents

XP-002756982; ChemDiv Screening Collection, “C614-0971”, Database CHEMCATS, Database accession No. 2058888426, May 13, 2015. ... XP-002756983; ChemDiv Screening Collection, “C614-0943”, Database CHEMCATS, Database accession No. 1904759099, May 13, 2015. ... XP-002756988; ChemDiv Screening Collection, “C614-0930”, Database CHEMCATS, Database accession No. 0674250759, May 13, 2015.

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Small molecules for disrupting the super elongation complex and inhibiting transcription elongation for cancer therapy

Ali Shilatifard [US]; Kaiwei Liang [US]; Edwin R. Smith [US]; Gary E. Schiltz [US]; Rama K. Mishra [US]; Kristen Stoltz [US]

Publication date: 2022-09-27 | Patent publication No.: US-11453640-B2 | Assignees: Northwestern University [US] | IPC: C07C235/74; A61P35/00; C07C235/78; C07D213/40; C07D213/75; C07D231/14; C07D239/36; C07D239/42; C07D241/20; C07D257/06; C07D261/18; C07D271/07; C07D277/46 | Oldest priority date: 2018-03-21 | Publication date: 2022-09-27

Score: 7.161399 | Text size: 203009 | Find: similar documents

Based on the structure of KL-1 (FIG. 1C), we performed a KL-1 similarity search with ChemDiv compounds and tested the top 32 most similar compounds. ... The candidate chemicals from the in silico screening were purchased from the vendors ChemDiv, ChemBridge and Enamine.

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INHIBITORS OF ANO6 AND THEIR USES THEREOF

OH, Changmok [KR]; KWON, Sungwook [KR]; LIM, Dami [KR]; LEE, Eunjung [KR]; LEE, Seolhee [KR]; YOON, Hongchul [KR]; AN, Kyung Mi [KR]; PARK, Joontae [KR]; CHO, Sung Min [KR]; CHOI, Won Gu [KR]; LEE, Min Goo [KR]; LEE, Jae Myun [KR]; NAMKUNG, Wan [KR]; LEE, JUNGWOO [KR]

Publication date: 2022-09-22 | Patent publication No.: WO-2022195522-A1 | Assignees: ILDONG PHARMACEUTICAL CO., LTD. [KR]; UIF (UNIVERSITY INDUSTRY FOUNDATION), YONSEI UNIVERSITY [KR] | IPC: A61K31/50; A61K31/505; A61K31/44; A61K31/506; A61K31/501; A61P31/14; C07D237/20; C07D239/42; C07D213/74; C07D405/04 | Oldest priority date: 2021-03-17 | Publication date: 2022-09-22

Score: 6.047818 | Text size: 388308 | Find: similar documents

Compound A24 (ChemDiv; Cat# F575-0482, 3-{[l-benzyl-2-(thiophen-2-yl)-lH-indol- 3-yl]methyl}-l-[(oxolan-2-yl)methyl]urea), Compound A24 (ChemDiv; Cat# F474-2423, ethyl 8-methyl-4-((4-(methylthio)benzyl)amino)-2-oxo-l,2-dihydroquinoline-3-carboxylate), abamectin (Cayman Chemical, Ann Arbor, MI, USA), ivermectin (Sigma-Aldrich, St. Louis, MO, USA), camostat mesylate (Sigma-Aldrich, #SML0057), BAPTA-AM (Sigma-Aldrich, #A1076), amphotericin B solution (Sigma-Aldrich, #A2942), and trypsin (Sigma-Aldrich, #T6567) were purchased commercially. ... For the high-throughput screening of a library of 54,000 drug like small-molecule compounds (Chemdiv, San Diego, CA, USA) and a library of 1,700 approved drugs (TargetMol, Boston, MA, USA), FRT-AN06 cells were treated with 25 mM compounds.

Bicyclic bromodomain inhibitors

John Frederick Quinn [US]; Bryan Cordell Duffy [US]; Shuang Liu [US]; Ruifang Wang [US]; May Xiaowu Jiang [US]; Gregory Scott Martin [US]; Gregory Steven Wagner [US]; Peter Ronald Young [US]

Publication date: 2022-09-20 | Patent publication No.: US-11446306-B2 | Assignees: Zenith Epigenetics Ltd. [CA] | IPC: A61K31/5377; A61K31/4184; A61K31/422; A61K31/423; A61K31/437; A61K31/4545; A61K31/496; A61K31/497; A61K31/498; A61K31/4985; A61K31/517; A61K31/52; A61K45/06; C07D413/04; C07D471/04; C07D473/34; A61P1/16; A61P11/00; A61P1/00; A61P1/02; A61P1/04; A61P1/18; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P3/12; A61P5/14; A61P5/50; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/14; A61P11/02; A61P11/16; A61P13/10; A61P13/12; A61P15/16; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P21/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P27/02; A61P27/04; A61P27/16; A61P29/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P37/08; A61P43/00 | Oldest priority date: 2013-06-21 | Publication date: 2022-09-20

Score: 1.8987279 | Text size: 524734 | Find: similar documents

ChemDiv, Inc. in Chemical Abstracts Record No. 1340694-11-8, Entered into the Registry File Nov. 4, 2011.

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Cystic Fibrosis Transmembrane Conductance Regulator Stabilizing Agents

Jan Steyaert [BE]; Els Pardon [BE]; Toon Laeremans [BE]; Cedric Govaerts [BE]; Magdalena Grodecka [PL]; Maud Sigoillot [BE]; Marie Overtus [BE]; Marianne Sylvia Carlon [BE]; Marjolein Ensinck [BE]; Abel Garcia-Pino [BE]

Publication date: 2022-09-15 | Patent publication No.: US-20220289837-A1 | Assignees: VIB VZW [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE]; UNIVERSITÉ LIBRE DE BRUXELLES [BE]; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D [BE] | IPC: C07K16/28; A61K45/06; A61K39/395; G16B15/30; A61K31/47 | Oldest priority date: 2019-04-30 | Publication date: 2022-09-15

Score: 4.3235645 | Text size: 231016 | Find: similar documents

PIM KINASE INHIBITOR COMPOSITIONS AND USES THEREOF

Mark J. Burk [US]; Brandon Chen [US]

Score: 8.611835 | Text size: 245096 | Find: similar documents

Numerous contract research organizations (CROs) offer PIM kinase assay services, including DiscoverX, Inc, (San Diego, Calif.), Reaction Biology Corporation (Malvern, Pa.), ChemDiv (San Diego, Calif.), and Cams Biosciences (Tokyo, Japan). ... The inhibitory activity of each compound against PIM kinases was measured with the LANCE® Ultra Kinase Assays by ChemDiv, Inc. ... All assays were performed by Reaction Biology Corporation (Malvern, Pa.) or ChemDiv, Inc.

Lipid containing formulations

Muthiah Manoharan [US]; Kallanthottathil G. Rajeev [US]; Akin Akinc [US]; Jayaprakash K. Nair [US]; Muthusamy Jayaraman [US]; Martin Maier [US]

Publication date: 2022-08-23 | Patent publication No.: US-11420931-B2 | Assignees: ARBUTUS BIOPHARMA CORPORATION [CA] | IPC: C07C219/06; A61K9/127; A61K31/325; C07C209/78; C07C233/36; C07C271/10; C07C323/25; A61K47/34 | Oldest priority date: 2006-10-03 | Publication date: 2022-08-23

Score: 10.328181 | Text size: 280810 | Find: similar documents

can be obtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet, Camelford, England; ChemDiv, SanDiego, Calif.

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COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DISEASES AND CONDITIONS

TARKHOV, Andrei Evgenevich [RU]; AVKHACHEV, Konstantin Aleksandrovich [RU]; BURMISTROVA, Olga Andreevna [RU]; KHOLIN, Maksim Nikolaevich [RU]; FEDICHEV, Petr Olegovich [RU]

Publication date: 2022-08-18 | Patent publication No.: WO-2022173333-A2 | Assignees: GERO PTE. LTD. [SG] | IPC: A61K45/00; A61K38/00; A61P9/00; A61P25/16; A61P25/28; A61P3/06; A61P19/00; A61P27/02; A61P35/00 | Oldest priority date: 2021-02-10 | Publication date: 2022-08-18

Score: 6.145057 | Text size: 697071 | Find: similar documents

examples of the providers: eMolecules, Inc, Bio-Techne Corporation (NASDAQ: TECH), Mcule, Enamine, ChemDiv, VitasM, UORSY, ChemBridge, LifeChemicals, ZelinskyInstitute, Specs, ChemicalBlock and Maybridge.

NOVEL SMALL MOLECULE COMPOUND INHIBITING SIGNAL TRANSMISSION PATH OF TLR7 AND TLR9 AND USE THEREOF

Sangdun CHOI [KR]; Haseeb MUHAMMAD [KR]; Mahesh PATRA [KR]; Yang-Seon CHOI [KR]

Score: 13.962267 | Text size: 71578 | Find: similar documents

compounds ZINC druglike 14,480,911 ZINC leadlike 5,449,805 Enamine 3,006,354 ChemBridge 1,591,767 ChemDiv 1,960,042 Life Chemicals 500,011 Maybridge 72,257 Total 27,061,147 The structures were cleaned up

METHODS, COMPOSITIONS AND COMPOUNDS FOR TREATING AGE-RELATED DISEASES AND CONDITIONS

FEDICHEV, Petr Olegovich [RU]; TARKHOV, Andrei Evgenevich [RU]; AVKHACHEV, Konstantin Aleksandrovich [RU]; BURMISTROVA, Olga Andreevna [RU]; KHOLIN, Maksim Nikolaevich [RU]

Publication date: 2022-08-18 | Patent publication No.: WO-2022173334-A2 | Assignees: GERO PTE. LTD. [SG] | IPC: A61K45/00; A61K38/00; A61P9/00; A61P25/16; A61P25/28; A61P3/06; A61P19/00; A61P27/02; A61P35/00 | Oldest priority date: 2021-02-10 | Publication date: 2022-08-18

Score: 2.3034768 | Text size: 2907387 | Find: similar documents

Compounds and methods for promoting stress resistance

Cynthia Kenyon [US]; Peichuan Zhang [US]; James Cregg [US]; Kean-Hooi Ang [US]; Michelle Arkin [US]

Publication date: 2022-08-16 | Patent publication No.: US-11413278-B2 | Assignees: The Regents of the University of California [US] | IPC: A61K31/443; A61P9/00; A61P3/10; A61P29/00; A61K31/12; A61K31/341; A61K31/404; A61K31/4184; A61K31/437; A61K31/4406; A61K31/4439; A61K31/45; A61K31/519; A61K31/55; A61K31/44; A61P35/00 | Oldest priority date: 2015-10-08 | Publication date: 2022-08-16

Score: 8.066998 | Text size: 606219 | Find: similar documents

a “diversity library” that contains 104,121 small molecules ( ̃24K from ChemBridge; ̃50K from ChemDiv; and ̃30K from SPECS) selected to maximize the coverage of chemical space.

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NOVEL ANTIFUNGAL COMPOUNDS

BISCHOFF, Matthias [DE]; LAMPE, Philipp [DE]; SIEVERS, Sonja [DE]; POLYCHRONIDOU, Vasiliki [DE]; ANTONCHICK, Andrey [DE]; THOMA, Annika [DE]; LUDWIG, Nicole [DE]; KAHMANN, Regine [DE]; MÜNCH, Karin [DE]; REISSMANN, Stefanie [DE]

Publication date: 2022-08-11 | Patent publication No.: WO-2022167503-A1 | Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. [DE]; TECHNISCHE UNIVERSITÄT DORTMUND [DE] | IPC: A01N43/40; A01N43/48; A01N43/54; C07D239/72; C07D471/04 | Oldest priority date: 2021-02-03 | Publication date: 2022-08-11

Score: 15.288118 | Text size: 171255 | Find: similar documents

(http://comas.mpi- dortmund.mpg.de/index.php/workflow) were obtained from the chemical providers ChemDiv and Enamine in form of dry film which was dissolved in DMSO to yield a 10 mM stock solution and ... library (http://comas.mpi-dortmund.mpg.de/index.php) consisting mostly of screening compounds from ChemDiv and Enamine and also includes compounds with known mode of action as well as proprietary compounds

COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THE SAME

THATCHER, Gregory R. [US]; SHEN, Zhengnan [US]; XIONG, Rui [US]; RATIA, Kiira [US]; RONG, Lijun [US]; COOPER, Laura [US]

Publication date: 2022-08-11 | Patent publication No.: WO-2022169891-A1 | Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US]; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS [US] | IPC: A61K31/24; C07C229/42; A61P31/12 | Oldest priority date: 2021-02-08 | Publication date: 2022-08-11

Score: 15.95058 | Text size: 328027 | Find: similar documents

by regulatory bodies in other countries (FIG.1B) and a 10,000-compound SMART library subset from ChemDiv (FIG. 1C). ... The libraries included in the screen were purchased from TargetMol (Bioactive Library) and ChemDiv (a 10,000-compound SMART library subset). ... An unbiased ChemDiv library (10,000-compound SMART library subset excluding PAINS compounds) and a biased, annotated

COMPOUND FOR TREATING NEURODEGENERATIVE DISORDERS

Boxun Lu [CN]; Yiyan Fei [CN]; Yu Ding [CN]; Yongjun Dang [CN]

Score: 14.432653 | Text size: 239332 | Find: similar documents

from Selleck, catalog number S1452; Compound 2: PubChem CID 5398649, can be purchased from ChemDiv, catalog numberD715-2435; Compound 3: Semaxanib, can be purchased from Selleck, CAS No. ... 6: can be purchased from TargetMol, CAS No. 842-01-3; Compound 7: can be purchased from ChemDiv.

SARBECOVIRUS BINDERS

SAELENS, Xavier [BE]; DE VLIEGER, Dorien [BE]; ROSSEY, Iebe [BE]; DE CAE, Sieglinde [BE]; SEDEYN, Koen [BE]; VAN SCHIE, Loes [BE]; EECKHAUT, Hannah [BE]; FIJALKOWSKA, Daria [BE]; STORTELERS, Catelijne [BE]; SCHEPENS, Bert [BE]; CALLEWAERT, Nico [BE]; REMAUT, Han [BE]; NERINCKX, Wim [BE]; ROOSE, Kenny [BE]; REITER, Dirk [BE]

Score: 9.930534 | Text size: 368045 | Find: similar documents

from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ, of California).

NOVEL ANTIFUNGAL COMPOUNDS

Publication date: 2022-08-10 | Patent publication No.: EP-4039094-A1 | Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. [DE] | IPC: A01N43/40; A01N43/48; A01N43/54; C07D239/72; C07D471/04 | Oldest priority date: 2021-02-03 | Publication date: 2022-08-10

Score: 18.151299 | Text size: 179069 | Find: similar documents

The tetrahydro-cyclopentapyrimidine compounds (Formula III) were purchased from ChemDiv using the "search for catalog numbers" option https://chemistryondemand.com:8443/eShop/. ... (http://comas.mpi-dortmund.mpg.de/index.php/workflow) were obtained from the chemical providers ChemDiv and Enamine in form of dry film which was dissolved in DMSO to yield a 10 mM stock solution and ... library (http://comas.mpi-dortmund.mpg.de/index.php) consisting mostly of screening compounds from ChemDiv and Enamine and also includes compounds with known mode of action as well as proprietary compounds ... Table 6: COMPOUNDChemDiv IDsIC50 1-C D468-0807 0.67 μM 2-C D468-0522 6.2 μM 3-C D468-0555 6.4 μM 4-C D468-0823 2 μM 5-C

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TETRAHYDRO IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS PD-L1 INTERNALIZATION INDUCERS

LIU, Phillip C. [US]; VOLGINA, Alla [US]; WYNN, Richard [US]; ZOLOTARJOVA, Nina [US]; WU, Liangxing [US]; XIAO, Kaijiong [US]; MEI, Song [US]; LU, Liang [US]; ZHU, Wenyu [US]; YE, Yingda [US]; WANG, Haisheng [US]; QIAN, Ding-Quan [US]; YAO, Wenqing [US]

Publication date: 2022-08-10 | Patent publication No.: EP-3558990-B1 | Assignees: Incyte Corporation [US] | IPC: C07D471/04; A61K31/437; A61P37/00; A61P35/00; A61P37/04; C07D213/81; C07D263/57; C07D413/14; C07D413/06; C07D519/00 | Oldest priority date: 2017-10-09 | Publication date: 2022-08-10

Score: 8.066998 | Text size: 801797 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

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NOVEL IMIDAZOPYRIMIDINE COMPOUNDS AND USES THEREOF

Ofer Levy [US]; David J. Dowling [US]; Francesco Borriello [US]; David A. Scott [US]; Spencer E. Brightman [US]; Frederic Feru [US]

Publication date: 2022-08-04 | Patent publication No.: US-20220242867-A1 | Assignees: Dana-Farber Cancer Institute, Inc. [US]; Children's Medical Center Corporation [US] | IPC: C07D487/04; A61K31/519; A61K45/06 | Oldest priority date: 2017-11-14 | Publication date: 2022-08-04

Score: 13.851352 | Text size: 270451 | Find: similar documents

bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex (see attached pdf of all libraries). ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).

25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR, IS A NOVEL SENOLYTIC

Chandani Limbad [US]; Ryosuke Doi [US]; Munemichi Ohe [JP]; Naoki Inoue [JP]

Score: 8.605278 | Text size: 351521 | Find: similar documents

and real screening services are commercially available from a number of suppliers (see, e.g., ChemDiv (San Diego, Calif.), and the like).

METHODS FOR THE IDENTIFICATION OF SARM1 NADASE ACTIVITY INHIBITORS AND USES THEREOF

Yarden OPATOWSKY [IL]

Score: 10.328181 | Text size: 245283 | Find: similar documents

Enamine (Drug-Like Set (DLS)) 20160 compounds; MayBridge (HitFinderTM Collection) 14400 compounds; ChemDiv (DIVERSet) 100000 compounds; Kinom Set (Kinom Set) 187 compounds; SGC (Epigenetic chemical probes)

A NEW MOLECULAR SCAFFOLD FOR TARGETING HRPN13

WALTERS, Kylie J. [US]; LU, Xiuxiu [US]; TARASOVA, Nadya I. [US]; SWENSON, Rolf Eric [US]; SABBASANI, Venkatareddy [US]; MOCK, Beverly Ann [US]; GAIKWAD, Snehal [US]; CITRIN, Deborah [US]; CHANDRAVANSHI, Monika [US]

Publication date: 2022-08-04 | Patent publication No.: WO-2022165099-A2 | Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US] | IPC: C07C255/44 | Oldest priority date: 2021-01-29 | Publication date: 2022-08-04

Score: 10.328181 | Text size: 315798 | Find: similar documents

commercially available (Enamine diversity set, Emolecules, Mcules, Asinex, UORSY, Chembridge, ChemDiv, ChemSpace) or capable of synthesis (Enamine’s diversity REAL database containing 15 million

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING MICROBIOME DYSREGULATIONS ASSOCIATED WITH CIRCADIAN CLOCK DISRUPTION

CHAMAILLARD, Mathias [FR]

Publication date: 2022-08-03 | Patent publication No.: EP-3458047-B1 | Assignees: Institut National de la Santé et de la Recherche Médicale (INSERM) [FR]; Université de Lille [FR]; Institut Pasteur De Lille [FR]; Centre National de la Recherche Scientifique CNRS [FR] | IPC: A61K31/352; A61K31/277; A61P25/20; A61P43/00 | Oldest priority date: 2016-05-20 | Publication date: 2022-08-03

Score: 13.775837 | Text size: 90652 | Find: similar documents

Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (San Diego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands), Timtec (Newark, DE), or alternatively can be

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PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA

DESAI, Sanjay A. [US]

Publication date: 2022-08-03 | Patent publication No.: EP-2696873-B1 | Assignees: The United States of America, as represented by The Secretary, Department of Health and Human Services [US] | IPC: C07D413/14; C07D409/04; C07D409/14; C07D239/84; C07D417/06; C07D241/44; C07D263/57; A61K31/498; A61K31/554; A61K31/433; A61P33/06; C07D491/048; C07D498/04; C07D277/54; C07D513/04; C07D281/16; C07K14/445 | Oldest priority date: 2011-04-12 | Publication date: 2022-08-03

Score: 15.288118 | Text size: 152665 | Find: similar documents

methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, CA or Peakdale Molecular Limited, High Peak, England. ... temperature using a commercial library of 50,000 compounds with > 90% purity confirmed by NMR (ChemDiv). Screens were performed in 384-well format with individual wells containing a single compound at

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Compositions and methods for the diagnosis and treatment of lymphatic system disorders

Hakon Hakonarson [US]; Dong Li [US]; Lifeng Tian [US]; Kenny Nguyen [US]; Patrick Sleiman [US]

Publication date: 2022-08-02 | Patent publication No.: US-11401553-B2 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/68; C12Q1/6883; A61P43/00; A61K31/4184; A61K31/436; A61K31/4427; A61K31/4709; A61K31/501; A61K31/519; A61K31/5377; A61K45/06 | Oldest priority date: 2016-08-31 | Publication date: 2022-08-02

Score: 12.011612 | Text size: 156918 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

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METHOD FOR ALPHAVIRUS INHIBITION

Glen A. COBURN [US]; Guo-Hua CHU [US]; Jodie C. HAMRICK [US]; Charlotte L. BOWSHER [US]; Daniel C. PEVEAR [US]

Score: 13.245268 | Text size: 95555 | Find: similar documents

the acid, 2-(2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]thiazin-3-ypacetic acid (available from ChemDiv, Inc., reference: Japan Patent JP63008387 A, Jan 14, 1988) (180 mg, 0.8 mmol) in DCM (16 mL) was added

RETROSYNTHESIS SYSTEMS AND METHODS

KONSTANTINOV, Anton [RU]; PUTIN, Evgeny Olegovich [RU]; ZAGRIBELNYY, Bogdan [CN]; IVANENKOV, Yan A. [RU]; ZAVORONKOVS, Aleksandrs [CN]

Score: 12.913692 | Text size: 142589 | Find: similar documents

ready-to-use compound aggregators like open-sourced PubChem, ZINC and ChEMBL or vendor stocks like ChemDiv, Enamine or commercial databases, such as Clarivate Analytics Integrity (Cortellis Drug Discovery

METHOD FOR SCREENING COMPOUND FOR TREATING OR PREVENTING POLYQ-RELATED NEURODEGENERATIVE DISEASES

Boxun Lu [CN]; Yiyan Fei [CN]; Yu Ding [CN]; Yongjun Dang [CN]

Score: 15.755042 | Text size: 132416 | Find: similar documents

from Specs, catalog number AN-655/15003575; Compound 4: PubChem CID 5398649, available from ChemDiv, catalog number D715-2435; Compound 5: Semaxanib, available from Selleck, CAS No. ... 377090-84-1; Compound 7: available from TargetMol, CAS No. 842-01-3; Compound 8: available from ChemDiv.

RETROSYNTHESIS SYSTEMS AND METHODS

Anton Konstantinov [RU]; Evgeny Olegovich Putin [RU]; Bogdan Zagribelnyy [HK]; Yan A. Ivanenkov [RU]; Aleksandrs Zavoronkovs [HK]

Score: 12.913692 | Text size: 139811 | Find: similar documents

NOVEL SMALL MOLECULE COMPOUND INHIBITING SIGNAL TRANSMISSION PATH OF TLR7 AND TLR9 AND USE THEREOF

CHOI, Sangdun [KR]; MUHAMMAD, Haseeb [KR]; PATRA, Mahesh [KR]; CHOI, Yang-Seon [KR]

Publication date: 2022-06-01 | Patent publication No.: EP-4006013-A1 | Assignees: Ajou University Industry-Academic Cooperation Foundation [KR] | IPC: C07D233/88; C07D405/04; A61K31/4168; A61K31/4178; A61P37/00; A61P29/00 | Oldest priority date: 2019-07-26 | Publication date: 2022-06-01

Score: 13.962267 | Text size: 71929 | Find: similar documents

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COMPOSITIONS FOR TREATING AND/OR PREVENTING CELL OR TISSUE NECROSIS SPECIFICALLY TARGETING CATHEPSIN C AND/OR CELA1 AND/OR CELA3A AND/OR STRUCTURALLY RELATED ENZYMES THERETO

Nathan, Ilana [IL]; Khalfin, Boris [IL]

Publication date: 2022-06-01 | Patent publication No.: EP-4005569-A2 | Assignees: ELA Pharma Ltd [IL] | IPC: A61K31/426; A61K31/00; A61K31/415; A61K31/4178; A61K31/4196; A61K31/4439; A61K31/454; A61K31/496; A61K31/4045; A61K31/428; A61K31/536; C07K16/40; C12N15/113; A61P9/10; A61P25/28; A61P39/00; A61P43/00; A61P25/00 | Oldest priority date: 2015-06-04 | Publication date: 2022-06-01

Score: 15.628418 | Text size: 275429 | Find: similar documents

All the compounds disclosed in Table 1 hereinabove were purchased from ChemDiv, San Diego, CA. ... 3D structure similarities and topological analogs The following compounds were prepared by vendor ChemDiv Inc. (San Diego, USA) and their respective ChemDiv I.D. numbers are shown in Table 4 below.

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Identification of stabilizers of multimeric proteins

Isabella A. Graef [US]; Mamoun M. Alhamadsheh [US]

Publication date: 2022-05-24 | Patent publication No.: US-11337935-B2 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/12; C07D231/12; A61K31/4196; A61K31/428; A61K31/433; C07D487/04; A61K31/519; A61K31/166; G01N21/64 | Oldest priority date: 2010-05-07 | Publication date: 2022-05-24

Score: 12.297968 | Text size: 142091 | Find: similar documents

120,000 compounds from the Stanford IITBC library were screened (Diverse compounds form Chemdiv, Chembridge, SPECS, and LOPAC1280-1280 compounds Library of Pharmacologically Active Compounds from

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METHODS OF PROMOTING CELLULAR MATURATION WITH AMPK ACTIVATORS

Charles E. MURRY [US]; Xiulan YANG [US]

Publication date: 2022-05-19 | Patent publication No.: US-20220152117-A1 | Assignees: UNIVERSITY OF WASHINGTON [US] | IPC: A61K35/34; A61K45/06; A61P3/04; A61P3/10; C12N5/0793; C12N5/077; C12N9/12 | Oldest priority date: 2019-03-18 | Publication date: 2022-05-19

Score: 10.988179 | Text size: 220455 | Find: similar documents

for example, from Enzo Life Sciences, Aurora Fine Chemicals, Exclusive Chemistry Ltd., ChemDiv, ChemBridge, TimTec Inc., AsisChem, and Princeton Biomolecular Research, among others.

COMPOSITIONS AND METHODS FOR TARGETING THE INTERACTION OF HOST MYO5B+D AND CORONAVIRUS M PROTEINS

TANGY, Frédéric [FR]; VIDALAIN, Pierre-Olivier [FR]; GOLDENRING, James R. [US]; ROLAND, Joseph T. [US]; LAPIERRE, Lynne A. [US]; MANNING, Elizabeth [US]; DE HAAN, Cornelis Alexander Maria [NL]

Score: 13.417523 | Text size: 100883 | Find: similar documents

ChemBridge Corporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, CA 92121, USA); Life Chemicals (1103 Orange Center Road,

SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS

ELLIOT J. ANDROPHY [US]; SAMY MEROUEH [US]; ZHIJIAN LU [US]; Anne RIETZ [US]

Score: 13.417523 | Text size: 108584 | Find: similar documents

#V012-2359), EIN-130(cat #V031-2694), and EIN-131(cat #V031-2717) were each purchased from ChemDiv.

Compositions and methods for the inhibition of pruritus

Mark A. Hoon [US]; Hans Juergen Solinski [DE]; James Inglese [US]; Patricia Dranchak [US]

Publication date: 2022-05-10 | Patent publication No.: US-11324725-B2 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services [US] | IPC: A61K31/422; A61P17/04; A61K31/5513; A61K31/55; A61K31/506; A61K31/4439; A61K31/497; A61K31/395; A61K31/4545 | Oldest priority date: 2017-11-03 | Publication date: 2022-05-10

Score: 18.49596 | Text size: 94307 | Find: similar documents

(Chemdiv Inc., catalog number S217-0244); (m) N-benzyl-1-(2-cyanobenzyl)-4-oxo-1,5-diazacycloundecane-8-carboxamide (Chemdiv Inc., catalog number S733-0866); or (n) N-benzyl-N-methyl-8-phenylimidazo[1,2-a]pyrazine-2-carboxamide (Chemdiv Inc., catalog number T425-0460). ... (Franklin, Mass.), JS-11 was from Chembridge (San Diego, Calif.), and JS-12-JS-14 were from Chemdiv (San Diego, Calif.

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NOVEL OXADIAZOLE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAM

YANAGISAWA, Katsuhiko [JP]; KAWAI, Akiyoshi [JP]

Publication date: 2022-05-04 | Patent publication No.: EP-3275440-B1 | Assignees: National Center for Geriatrics and Gerontology [JP] | IPC: A61K31/4245; A61K31/41; A61K31/4178; A61K31/4196; A61K31/4709; A61K31/5377; A61P25/28 | Oldest priority date: 2015-03-25 | Publication date: 2022-05-04

Score: 12.011612 | Text size: 312903 | Find: similar documents

UORSY Ltd., Vitas-M Laboratory Ltd., Interbioscreen Ltd., Interchim Inc., Ryan Scientific Inc., ChemDiv Inc., through Namiki Shoji Co., Ltd. or Kishida Chemical Co., Ltd., when purchased in Japan.

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POSITIVE ALLOSTERIC MODULATORS OF SWEET TASTE

Anandasankar RAY [US]; Joel KOWALEWSKI [US]

Score: 13.594319 | Text size: 224595 | Find: similar documents

other well-known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego, Calif.

N-[5-[(3,4-DIMETHOXYPHENYL)METHYL]-1,3,4-THIADIAZOL-2-YL]-2-METHOXY-BENZENEACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS CFTR ACTIVATORS FOR TREATING CONSTIPATION OR CHOLESTASIS

VERKMAN, Alan [US]; LEVIN, Marc, H. [US]; CIL, Onur [US]

Publication date: 2022-04-27 | Patent publication No.: EP-3394083-B9 | Assignees: The Regents of the University of California [US] | IPC: C07D285/135; C07D417/12; C07K5/078; C07K5/062; A61P27/04; A61P1/10 | Oldest priority date: 2015-12-24 | Publication date: 2022-04-27

Score: 16.176003 | Text size: 419260 | Find: similar documents

was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, California, USA) and Asinex (Winston-Salem, North Carolina, USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, California, USA) and Asinex (Winston-Salem, North Carolina, USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.

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USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE

David J. Dowling [US]; Ofer Levy [US]; Francesco Borriello [US]; David A. Scott [US]; Spencer E. Brightman [US]

Publication date: 2022-04-21 | Patent publication No.: US-20220118085-A9 | Assignees: Children's Medical Center Corporation [US]; Dana-Farber Cancer Institute, Inc. [US] | IPC: A61K39/39; A61K45/06; A61K31/739; A61K31/4535; A61K31/381; A61K31/496; A61K31/438; A61K31/4025 | Oldest priority date: 2018-07-27 | Publication date: 2022-04-21

Score: 12.211837 | Text size: 385599 | Find: similar documents

bioactive and commercial libraries from various sources including commercial libraries such as ChemDiv, ChemBridge, and Asinex. ... known bioactive and commercial libraries from various sources (e.g., commercial libraries such as ChemDiv, ChemBridge, and Asinex; see attached pdf of all libraries).

METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS

Beibei Chen [US]; Toren Finkel [US]; Yuan Liu [US]

Score: 15.064883 | Text size: 206195 | Find: similar documents

The following compounds (free base) provided in Table 2 were obtained from commercial sources (ChemDIV, Inc. and Mol port, Inc.): TABLE 2 No. ... The following compounds shown in Table 4 were purchased from ChemDIV, Inc. TABLE 4 No.

COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATIC SYSTEM DISORDERS

Hakon Hakonarson [US]; Yoav Dori [US]; Dong Li [US]; Michael March [US]; Charlly Kao [US]; Christoph Seiler [US]

Publication date: 2022-04-14 | Patent publication No.: US-20220112558-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6883; A61K45/06; C12Q1/6869; C12Q1/6827; A61K31/4184 | Oldest priority date: 2018-09-07 | Publication date: 2022-04-14

Score: 11.227331 | Text size: 252490 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

COMPOUNDS WITH GLUCOCORTICOID SPARING EFFECTS AND USES THEREOF

CARSON, Dennis, A. [US]; HAYASHI, Tomoko [US]; CORR, Mary, Patricia [US]; COTTAM, Howard, B. [US]; HOSOYA, Tadashi [US]; SHUKLA, Nikunj [US]

Publication date: 2022-04-14 | Patent publication No.: WO-2022076473-A1 | Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/495; A61K31/505; A61K31/519; C07D487/02; C07D487/04 | Oldest priority date: 2020-10-05 | Publication date: 2022-04-14

Score: 12.913692 | Text size: 115726 | Find: similar documents

commercially purchased. [0091] Hit compounds were purchased from Chem Bridge (San Diego, CA) and ChemDiv (San Diego, CA) and dissolved in dimethyl sulfoxide (DMSO, Sigma Aldrich, St Louis.

COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS

HOON, Mark A. [US]; SOLINSKI, Hans Juergen [DE]; INGLESE, James [US]; DRANCHAK, Patricia [US]

Publication date: 2022-04-13 | Patent publication No.: EP-3703682-B1 | Assignees: The United States of America, as represented by The Secretary, Department of Health and Human Services [US] | IPC: A61K31/422; A61P43/00; A61P17/04; A61K31/5517; A61K31/5513; A61K31/55; A61K31/519; A61K31/506; A61K31/4985; A61K31/4545; A61K31/439; A61K31/437; A61K31/42; A61K31/015; A61K31/4184; C07D413/12; C07D471/04; C07D487/04 | Oldest priority date: 2018-05-14 | Publication date: 2022-04-13

Score: 13.775837 | Text size: 86296 | Find: similar documents

Discovery (Franklin, MA), JS-11 was from Chembridge (San Diego, CA), and JS-12 - JS-14 were from Chemdiv (San Diego, CA).

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FLY AVATARS FOR CANCER AND USES THEREOF

CAGAN, Ross [US]; BANGI, Erdem [US]

Publication date: 2022-04-13 | Patent publication No.: EP-3397051-B1 | Assignees: Icahn School of Medicine at Mount Sinai [US] | IPC: A01K67/033; C07K14/82; G01N33/50; A61K31/405; A61K31/519; C12N9/16 | Oldest priority date: 2015-12-30 | Publication date: 2022-04-13

Score: 15.95058 | Text size: 240334 | Find: similar documents

Compound Library MedChem Express MAPK Compound Library MedChem Express Akt-Targeted Library ChemDiv PI3K-Targeted Library ChemDiv KRAS-Targeted Library ChemDiv EXPRESS-Pick Collection ChemBridge DIVERSetTM-EXP ChemBridge CORE Library ChemBridge DIVERSetTM-CL

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COMBINATIONS, NANOPARTICLES AND METHODS FOR CONTROLLING NATURAL KILLER CELL ACTIVATION AND FUNCTION

Mira BARDA-SAAD [IL]

Score: 8.902286 | Text size: 331890 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof

Publication date: 2022-03-08 | Patent publication No.: US-11268952-B2 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; C07C233/65; C07C235/54; C07C275/30; C07C275/34; C07D307/84; C07D317/68; G01N33/566; G01N33/74; A23L27/20; C07D263/56; C07D213/81; C07D213/85; C07D215/48; C07D217/06; C07D231/14; C07D333/24; C07D333/38; C07D401/04; C07D409/12; C07D417/12; C07D261/18; C07D271/12; C07D275/03; C07D209/08; C07D277/64; C07D209/42; C07D285/135; C07D213/40; C07D307/52; C07D307/68; C07D307/79; C07D307/82; G01N33/50; A23L2/56; A61K8/49; A61K8/55; A61K47/22; A61K47/24; C07D405/12; C07F9/655; A23L27/00 | Oldest priority date: 2003-08-06 | Publication date: 2022-03-08

Score: 9.562369 | Text size: 374581 | Find: similar documents

offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego Calif., Chembridge of San Diego Calif.

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SMALL MOLECULE MODULATORS OF GSK-3 ACTIVITY

ELDAR-FINKELMAN, Hagit [IL]; SENDEROWITZ, Hanoch [IL]

Publication date: 2022-03-03 | Patent publication No.: WO-2022044024-A1 | Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD. [IL]; BAR-ILAN UNIVERSITY [IL] | IPC: C07D413/14; C07D413/10; C07D413/04; C07D491/113; C07F9/38; A61K31/496; A61K31/4439; A61K31/438; A61K31/675; A61P25/28; A61P25/24; A61P3/10; A61P9/00; A61P9/10; A61P33/00; A61P33/06; A61P35/00; A61P43/00 | Oldest priority date: 2020-08-31 | Publication date: 2022-03-03

Score: 12.011612 | Text size: 173651 | Find: similar documents

by virtual screening were purchased from MolPort Riga, Latvia, that supplied compounds from ChemDiv Inc., San Diego, CA USA, Specs, Zoetermeer, The Netherlands, and Enamine Ltd. NJ, USA.

ANTHRANILIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS

Otto PHANSTIEL, IV [US]; Holly MOOTS [US]; Patrick MALONEY [US]; Paul HERSHBERGER [US]; Satyamaheshwar PEDDIBHOTLA [US]

Publication date: 2022-03-03 | Patent publication No.: US-20220064133-A1 | Assignees: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US]; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE [US] | IPC: C07D295/155; C07D211/46; A61K45/06 | Oldest priority date: 2018-08-10 | Publication date: 2022-03-03

Score: 18.151299 | Text size: 199883 | Find: similar documents

round of SAR was primarily fueled by 38 compounds, which were purchased from commercial vendors (ChemDiv) while a robust synthetic route was under development. ... (0800678) 6 13.3 ± 0.04 EC8 = 6 EC25 = 6 (8-2) 9 (0754479) 8 16.8 ± 0.1 EC49 = 8 EC5 = 8 (8-3) ChemDiv (F687-0882) 9 >50 EC38 = 9 EC11 = 8 (8-4) ChemDiv (F687-0884) 9 46.3 ± 0.02 EC43 = 9 EC0 = 9 (8-5) 33 (0800676) 8 22. ... In terms of toxicity profiles, compounds ChemDiv F687-0882 and ChemDiv F687-0884 and compounds 50 and 64 gave IC50 values >38 μM and were deemed relatively non-toxic.

Cells expressing apolipoprotein E and uses thereof

Susan L. Lindquist [US]; Priyanka Narayan [US]

Publication date: 2022-03-01 | Patent publication No.: US-11261453-B2 | Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C12N15/81; C07K14/775; C07K14/47; G01N33/92; C12Q1/02; G01N33/50; G01N33/68; A61K38/00 | Oldest priority date: 2014-09-12 | Publication date: 2022-03-01

Score: 8.066998 | Text size: 401412 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

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QUORUM SENSING INHIBITORS AND METHODS OF USE

VAN KESSEL BOCHMAN, Julia, Cathering [US]; BROWN, Laura, Caroline [US]

Score: 15.755042 | Text size: 154017 | Find: similar documents

We screened ~60,000 molecules in the ChemBridge and Chemdiv libraries and identified nine compounds that inhibited LuxR activation and/or repression but did ... P1120 D05 and P0074 N08 were purchased from EnamineStore, and P0053 118 was purchased from ChemDiv.

COMPOUND FOR TREATING NEURODEGENERATIVE DISORDERS

LU, Boxun [CN]; FEI, Yiyan [CN]; DING, Yu [CN]; DANG, Yongjun [CN]

Score: 14.432653 | Text size: 232331 | Find: similar documents

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TREX1 INHIBITORS AND USES THEREOF

PERRINO, Fred W. [US]; HOLLIS, Thomas [US]; HARVEY, Scott E. [US]; HEMPHILL, Wayne O. [US]

Score: 18.57923 | Text size: 91650 | Find: similar documents

(HTS) We applied structure-based virtual screening (SBVS) to the commercial 150k-compound ChemDiv Diversity Library and the ~1.2M-compound ChemBridge CORE+EXPRESS libraries. ... The top-scoring 698 and 2004 compounds from the ChemDiv and ChemBridge libraries, respectively, were selected for further study and ordered as physical ... All ChemDiv and Chembridge candidates plus 51/222 (-23%) of the Nanosyn candidates were commercially available, ... The compounds are available from one or more of the following vendors: Ambinter, ChemDiv, ChemBridge, Nanosyn, Sigma-Aldrich.

COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH UNCONTROLLED INFLAMMATORY RESPONSES

Jason Barbour [US]; David Ott [US]

Publication date: 2022-02-03 | Patent publication No.: US-20220031701-A1 | Assignees: Synkrino Biotherapeutics, Inc. [US] | IPC: A61K31/515; A61P37/06; A61P19/02; G16B25/10; G16B40/00; A61K31/437; A61K31/496; A61K31/50; A61K45/06; C12Q1/6883 | Oldest priority date: 2018-08-21 | Publication date: 2022-02-03

Score: 16.251385 | Text size: 87934 | Find: similar documents

Each compound is identified by its ChemDiv catalog number. Values in Table 1 are reported as degree of change from the control state. ... TABLE 1 CompoundChemDiv Compound IdentifierNormalized Average of MIG/CXCL9Normalized Average of IP-10/CXCL10Normalized

TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

Steven Albert Everett [US]; Saraj Ulhaq [GB]

Publication date: 2022-02-03 | Patent publication No.: US-20220031852-A1 | Assignees: University Court of the University of Dundee [GB] | IPC: A61K47/54; A61K31/343; A61K31/352; A61K31/4184; A61K31/428; A61K31/664; C07D307/80; C07D311/16; C07D311/18; C07D405/04; C07D405/12; C07D405/14; C07D407/12; C07D409/12; C07D417/12; C07D487/04; C07D491/22; A61K31/37; A61K31/381; A61K31/513; A61K31/52; A61K31/665 | Oldest priority date: 2009-05-01 | Publication date: 2022-02-03

Score: 16.116692 | Text size: 220210 | Find: similar documents

for CYP181 The target enzyme CYP1B1 was screened against two commercial libraries including the ChemDiv Diversity 50,000 test compound collection and the ChemDiv Kinase Targeted 10,000 test compound collection with a view to identifying activity differentiating ... cross validation on a training set selected from 45,000 and 9,000 test compounds from the ChemDiv Diverse and Kinase libraries.

COMPOSITIONS AND METHODS FOR ACTIVATING NRF2-DEPENDENT GENE EXPRESSION

Raymond MOELLERING [US]; John COUKOS [US]; Gihoon LEE [US]; Jae Won CHANG [US]; Gokhan MUTLU [US]

Score: 15.518069 | Text size: 139140 | Find: similar documents

CBR-470-0 and CBR-581-9 were from ChemDiv. CBR-470-1 (initially from ChemDiv as D470-2172) and related analogs were synthesized in house according to full methods described in

ANTIBACTERIAL COMPOUNDS AND USES THEREOF

Paula I. WATNICK [US]; Julie Szu YU [US]

Publication date: 2022-01-27 | Patent publication No.: US-20220023270-A1 | Assignees: The Children's Medical Center Corporation [US] | IPC: A61K31/433; A61K31/165; A61K31/4525; A61K31/341; A61K31/357; A61K31/519; A61P31/04 | Oldest priority date: 2018-12-06 | Publication date: 2022-01-27

Score: 14.637417 | Text size: 190761 | Find: similar documents

A chemical library comprised of compounds from the Targeted Diversity Library at ChemDiv and purchased and maintained by the Institute of Chemistry and Chemical Biology-Longwood ... Compound O06 was purchased from ChemDiv under the catalog number 8019-0105.

CFTR regulators and methods of use thereof

Alan S. Verkman [US]; Marc H. Levin [US]; Onur Cil [US]; Sujin Lee [US]

Publication date: 2022-01-25 | Patent publication No.: US-11230535-B2 | Assignees: The Regents of the University of California [US] | IPC: C07D251/52; C07D251/46; A61P1/10; A61P27/04; A61K31/496; A61K31/53; A61K31/5377; A61K31/55; A61K45/06; C07D403/04; C07D413/12 | Oldest priority date: 2015-12-24 | Publication date: 2022-01-25

Score: 15.000084 | Text size: 592839 | Find: similar documents

was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested. ... was done using a diverse collection of 120,000 drug-like synthetic compounds obtained from ChemDiv Inc. (San Diego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600 commercially available analogs (ChemDiv Inc.) of active compounds identified in the primary screen were tested.

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SUBSTITUTED 4-(3-AMINOPROP-1-YL)AMINOQUINOLINE ANALOGS AS MODULATORS OF MELANOMA-ASSOCIATED ANTIGEN 11 UBIQUITIN LIGASE

POTTS, Ryan [US]; CHEN, Taosheng [US]; RANKOVIC, Zoran [US]; MIN, Jaeki [US]; LIN, Wenwei [US]; YANG, Seung Wook [US]; MAYASUNDARI, Anand [US]

Score: 9.562369 | Text size: 338749 | Find: similar documents

commercial sources including Sigma, Microsource (Gaylordsville, CT), selleckchem (Houston, TX), ChemDiv (San Diego, CA), ChemBridge (San Diego, CA), Enamine (Monmouth Jet.

METHOD FOR SCREENING COMPOUND FOR TREATING OR PREVENTING POLYQ-RELATED NEURODEGENERATIVE DISEASES

LU, Boxun [CN]; FEI, Yiyan [CN]; DING, Yu [CN]; DANG, Yongjun [CN]

Publication date: 2022-01-19 | Patent publication No.: EP-3940384-A1 | Assignees: Fudan University [CN] | IPC: G01N33/68; G01N33/58; G01N21/64; G01N21/552; G01N21/76; G01N25/48; A61K31/404; A61K31/517; A61K31/352; A61P25/16; A61P25/28 | Oldest priority date: 2019-10-21 | Publication date: 2022-01-19

Score: 15.755042 | Text size: 130423 | Find: similar documents

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TYROSINE, TRYPTOPHAN AND PHENYLALANINE AS mTOR AGONISTS MEDIATING PROTEASOME DYNAMICS, COMPOSITIONS, METHODS AND USES THEREOF IN THERAPY, AND PROGNOSTIC METHODS FOR DRUG-RESISTANCE

LIVNEH, Ido [IL]; COHEN-KAPLAN, Victoria [IL]; CIECHANOVER, Aaron [IL]; GOLDHIRSH, Gilad [IL]; ZOHAR, Yaniv [IL]; LAVI, Noa [IL]; FABRE, Bertrand Francois [FR]

Publication date: 2022-01-13 | Patent publication No.: WO-2022009212-A1 | Assignees: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. [IL]; RAMBAM MED-TECH LTD. [IL] | IPC: A61K31/198; A61P35/00; G01N33/50 | Oldest priority date: 2020-07-09 | Publication date: 2022-01-13

Score: 7.592094 | Text size: 469435 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

S3QELS TO PROTECT AGAINST INTESTINAL PERMEABILITY

Mark A. Watson [GB]; Martin D. Brand [US]; Pankaj Kapahi [US]

Publication date: 2022-01-06 | Patent publication No.: US-20220000873-A1 | Assignees: Buck Institute for Research on Aging [US] | IPC: A61K31/519; A61K31/517; A61K31/343; A61K31/4365; A61K31/495; A61K31/445; A61P1/00; A61P3/04 | Oldest priority date: 2018-12-12 | Publication date: 2022-01-06

Score: 12.297968 | Text size: 137180 | Find: similar documents

Thus, for example, the following S3QELs are available from Chemdiv: S3QEL-1 (catalog ID K284-4710), S3QEL-1.1 (K284-4711), S3QEL-1.2 (K284-4767), S3QEL-1.

Ligands of the mu, kappa, and delta opioid receptors

Evan N. Feinberg [US]; Vijay S. Pande [US]; Susruta Majumdar [US]; Gavril Pasternak [US]

Publication date: 2022-01-04 | Patent publication No.: US-11213518-B2 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US]; Memorial Sloan-Kettering Cancer Center [US] | IPC: A61K31/4453; A61K31/415; A61K9/00 | Oldest priority date: 2017-11-14 | Publication date: 2022-01-04

Score: 19.328047 | Text size: 78827 | Find: similar documents

5421855 298.471 [[image:EMI-C00003]] 4 ChemBridge Corp 5359784 286.419 [[image:EMI-C00004]] 5 ChemDiv, Inc. K416-0034 331.45 [[image:EMI-C00005]] 6 ChemDiv, Inc. 6030-4029 277.408 [[image:EMI-C00006]] 7 ChemDiv, Inc. D171-0103 284.403 [[image:EMI-C00007]] 8 ChemDiv, Inc. K808-9296 317.388 [[image:EMI-C00008]] 9 ChemDiv, Inc. C296-0706 379.43 [[image:EMI-C00009]] 10 ChemDiv, Inc. C656-0381 347.353 [[image:EMI-C00010]] 11 InterBioScreen Ltd. STOCK1S-36272 255.

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Isolated human lung progenitor cells and uses thereof

Jayaraj Rajagopal [US]; Hongmei Mou [US]

Publication date: 2022-01-04 | Patent publication No.: US-11214769-B2 | Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC: C12N5/074; C12N5/071; A61K35/42; A61L27/38; A61L27/56; A61L27/58; G01N33/68; A61K9/00 | Oldest priority date: 2012-01-13 | Publication date: 2022-01-04

Score: 9.930534 | Text size: 267627 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

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Method to prevent cancer metastasis and inhibit inflammation by inhibition of p68 interaction with calmodulin

Zhi-Ren Liu [US]; Haizhen Wang [US]

Score: 13.245268 | Text size: 92806 | Find: similar documents

of chemical libraries including but not limited to ChemBridge Corporation (San Diego, Calif.), ChemDiv (San Diego, Calif.), Life Chemicals (Orange, Conn.), and Maybridge (Cornwall, UK).

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COMPOSITIONS AND METHODS FOR SUPPRESSING AND/OR TREATING METABOLIC DISEASES AND/OR A CLINICAL CONDITION THEREOF

Kang-Yell Choi [KR]; Seol Hwa Seo [KR]; Eunhwan Kim [KR]

Publication date: 2021-12-30 | Patent publication No.: US-20210403432-A1 | Assignees: CK Biotech Inc. [KR] | IPC: C07D215/38; C07D487/04; C07D471/04; C07D207/44; C07D513/04; C07D239/42; C07D498/04; C07D209/40; C07D217/16; C07C229/36; C07D309/38; C07D311/30; C07C237/48; C07C39/215; C07D295/088; C07D487/22; A61P3/04; A61P3/10; G01N33/68 | Oldest priority date: 2018-10-15 | Publication date: 2021-12-30

Score: 15.319015 | Text size: 228995 | Find: similar documents

that inhibited the CXXC5-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described. ... 2280 compounds assayed in 96-well plates as single compounds at 10 mM in DMSO Small molecules ChemDiv and Sigma LOPAC 1280 Screen Format Concentration(s) tested Plate controls Reagent/compound ... of the CXXC5-DVL interface, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5-DVL interaction

COMPOSITIONS AND METHODS FOR USE IN COMBINATION FOR THE TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES

HAKONARSON, Hakon [US]; LI, Yun Rose [US]; KEATING, Brendan [US]

Score: 9.930534 | Text size: 296191 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

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MICROFLUIDIC DEVICE AND USES THEREOF

Doron GERBER [IL]

Score: 9.22053 | Text size: 315123 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

RETROSYNTHESIS-RELATED SYNTHETIC ACCESSIBILITY

ZAGRIBELNYY, Bogdan [CN]; PUTIN, Evgeny Olegovich [RU]; FEDORCHENKO, Sergei Andreevich [RU]; IVANENKOV, Yan A. [RU]; ZAVORONKOVS, Aleksandrs [CN]

Score: 14.350686 | Text size: 86172 | Find: similar documents

-to-use compound aggregators like open-sourced PubChem, ZINC and ChEMBL or vendor stocks like ChemDiv, Enamine or commercial databases such as Clarivate Analytics Integrity (Cortellis Drug Discovery

SMALL MOLECULE ACTIVATORS OF INTERFERON REGULATORY FACTOR 3 AND METHODS OF USE THEREOF

STEVENS, Susan [US]; STENZEL-POORE, Mary [US]; FOSS, Marie [US]; NILSEN, Aaron [US]; JIN, Haihong [US]

Score: 9.22053 | Text size: 295182 | Find: similar documents

library, the ChemBridge CORE Library, and two focused antiviral libraries from Life Chemicals and ChemDiv.

CELL ENTRY-MODULATING AGENTS AND USES THEREFOR

JENNINGS, Michael Paul [AU]; DAY, Christopher James [AU]; KIEFEL, Milton [AU]; HASELHORST, Thomas [AU]

Publication date: 2021-11-11 | Patent publication No.: WO-2021222988-A1 | Assignees: GRIFFITH UNIVERSITY [AU] | IPC: A61K38/10; A61K31/4184; A61K31/4188; A61K31/4745; A61K31/496; A61K31/655; C07D491/22; C07K7/08; A61P31/14 | Oldest priority date: 2020-05-07 | Publication date: 2021-11-11

Score: 11.227331 | Text size: 213173 | Find: similar documents

- 1,050, eDrugs - 1,610, Ligandbox Kegg - 5,814, PRESTWICK OFF PATENTS - 2,062, OTAVA - 9,765, CHEMDIV - 33,145) as 2D SDF molecular format.

CFTR REGULATORS AND METHODS OF USE THEREOF

Alan S. Verkman [US]; Marc H. Levin [US]; Onur Cil [US]; Mark J. Kurth [US]

Publication date: 2021-11-11 | Patent publication No.: US-20210347742-A1 | Assignees: The Regents of the University of California [US] | IPC: C07D241/44; C07D403/04; C07D405/04; C07D498/06; C07D409/04; C07D401/06; C07D405/06; C07D409/06 | Oldest priority date: 2015-12-24 | Publication date: 2021-11-11

Score: 15.528575 | Text size: 712123 | Find: similar documents

COMPOSITIONS AND METHODS FOR TARGETING A VIRAL INFECTION

Bing CHEN [US]; Gary FREY [US]; Tianshu XIAO [US]

Score: 13.489152 | Text size: 294973 | Find: similar documents

1 (Winston-Salem, N.C.), Bionet (Ryan Scientific, Mount Pleasant, S.C.), CEREP (Redmond, Wash.), ChemDiv (San Diego, Calif.), and ChemBridge (San Diego, Calif. ... 1 (Winston-Salem, N.C.), Bionet (Ryan Scientific, Mount Pleasant, S.C.), CEREP (Redmond, Wash.), ChemDiv (San Diego, Calif.), and ChemBridge (San Diego, Calif.

Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia

David J. Tweardy [US]; Moses M. Kasembeli [US]; Marvin X. Xu [CN]; Thomas Kristian Eckols [US]

Publication date: 2021-11-02 | Patent publication No.: US-11161831-B2 | Assignees: Baylor College of Medicine [US] | IPC: C07D333/34; A61K31/47; A61K31/4406; A61K31/415; A61K31/381; A61K31/357; A61K31/145; C07D215/36; C07D213/71; C07D231/18; C07D319/18; C07C311/08; C07C311/10; C07C311/13; C07C311/31; C07C311/24; C07C311/29; C07C311/44; C07C311/49; C07C311/06; A61K31/06; A61K31/18; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4196; A61K31/42; A61K31/428; A61K31/45; A61K31/454; A61K31/4704; A61K31/4709; A61K31/513; C07C311/21; C07C323/49; C07C381/06; A61K45/06 | Oldest priority date: 2013-07-18 | Publication date: 2021-11-02

Score: 14.233541 | Text size: 279831 | Find: similar documents

Commercial chemical databases (Chembridge, Asinex, ChemDiv, Enamine, Keyorganics and Life Chemicals) were chosen as sources of compounds for screening in ... The databases searched included ChemBridge, LifeChemicals, Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for a total of 2.47 million compounds.

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Compounds that enhance Atoh1 expression

Albert Edge [US]; Sang-Jun Jeon [KR]; Kathleen Seyb [US]; Marcie Glicksman [US]; Lixin Qiao [US]; Gregory D. Cuny [US]

Publication date: 2021-11-02 | Patent publication No.: US-11160808-B2 | Assignees: Massachusetts Eye & Ear Infirmary [US]; Brigham & Women's Hospital, Inc. [US] | IPC: A61K31/5377; A61K31/343; A61K31/381; A61K31/415; A61K31/423; A61K31/4245; A61K31/426; A61K31/428; A61K31/341; A61K31/4184; A61K9/00; A61K31/353; A61K31/4436; A61K31/496; A61K31/498; A61K31/517; A61K31/519; A61K35/28; A61K35/545; A61K31/352; A61K31/404; A61K31/4155; A61K31/4192; A61K31/4365; A61K31/437; A61K31/44; A61K31/4439 | Oldest priority date: 2008-02-07 | Publication date: 2021-11-02

Score: 20.760141 | Text size: 210379 | Find: similar documents

N-(4-bromo-3- methylphenyl) quinazolin-4-amine CHEMDIV (3651-6031) CP- 0067053 [[image:EMI-C00070]] 60. N-(4-methoxyphenyl) quinazolin-4-amine CHEMDIV (4491-0691) CP- 0072720 [[image:EMI-C00071]] 61. N-(3-methoxyphenyl)- 9H-purin-6-amine CHEMDIV (8009-2985) CP- 0079810 [[image:EMI-C00072]] 62. N,N-diethyl-1-m-tolyl- 1H-pyrazolo[3,4- d]pyrimidin-4-amine CHEMDIV (K402- 0503) or IFLAB/ LIFE- CHEMICALS (F0518- 0004) CP- 0061777 [[image:EMI-C00073]] 63. (5-(4- bromophenyl)furan-2- yl)(morpholino)methanone CHEMDIV (1975-0198) CP- 0066008 [[image:EMI-C00074]] 64. (Z)-4-bromo-N′-(furan-2- carbonyloxy)benzimida- mide CHEMDIV (4260-1000) CP- 0072253 [[image:EMI-C00075]] 65. N-(4-iodophenyl)furan-2- carboxamide CHEMDIV (8002-5214) CP- 0099289 [[image:EMI-C00076]] 66.

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COMPOSITIONS AND METHODS FOR SUPPRESSING AND/OR TREATING A GROWTH RELATED DISEASE AND/OR A CLINICAL CONDITION THEREOF

Kang-Yell Choi [KR]; Sehee Choi [KR]; Seol Hwa Seo [KR]; Eunhwa Kim [KR]

Publication date: 2021-10-21 | Patent publication No.: US-20210323918-A1 | Assignees: CK Biotech Inc. [KR] | IPC: C07D209/34; A61P19/08; C07D513/14; C07D221/18; C07C237/48; C07D487/22; G01N33/68; A61K9/00 | Oldest priority date: 2018-10-15 | Publication date: 2021-10-21

Score: 17.002005 | Text size: 122516 | Find: similar documents

that inhibited the CXXCS-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described ... 2280 compounds assayed in 96-well plates as single compounds at 10 mM in DMSO Small molecules ChemDiv and Sigma LOPAC 1280 Screen Format Concentration(s) tested Plate controls Reagent/compound ... delay growth plate senescence, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5-DVL interaction

SMALL MOLECULE ANTIVIRAL DRUG TREATMENT FOR HUMAN PAPILLOMAVIRUS INFECTIONS

ANDROPY, Elliot J. [US]; MEROUEH, Samy [US]; LU, Zhijian [US]

Publication date: 2021-10-21 | Patent publication No.: WO-2021212010-A2 | Assignees: THE TRUSTEES OF INDIANA UNIVERSITY [US]; KOVINA THERAPEUTICS INC. [US] | Oldest priority date: 2020-04-17 | Publication date: 2021-10-21

Score: 13.245268 | Text size: 115556 | Find: similar documents

V012-2359), EIN-130(cat# V031-2694), and EIN-131(cat# V031-2717) were each purchased from ChemDiv.

Compositions and methods for treating diseases associated with uncontrolled inflammatory responses

Jason Barbour [US]; David Ott [US]

Publication date: 2021-10-19 | Patent publication No.: US-11147815-B2 | Assignees: Synkrino Biotherapeutics, Inc. | IPC: A61K31/495; A61K31/496; A61K31/513; A61K31/435; A61P19/02; A61P35/00; A61K31/515; A61K31/437; A61K31/50; A61K45/06; C12Q1/6883; G16B40/00; G16B25/10; A61P37/06 | Oldest priority date: 2018-08-21 | Publication date: 2021-10-19

Score: 16.251385 | Text size: 92960 | Find: similar documents

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METHODS AND COMPOSITIONS TO TREAT CANCER

Jeffrey A. Whitsett [US]; Yutaka Maeda [US]; Takuya Fukazawa [JP]

Publication date: 2021-10-14 | Patent publication No.: US-20210315903-A1 | Assignees: Children's Hospital Medical Center [US] | IPC: A61K31/5377; A61K31/429; A61P35/00; A61K31/4427; A61K31/4375; A61K31/444 | Oldest priority date: 2016-07-28 | Publication date: 2021-10-14

Score: 14.656486 | Text size: 44997 | Find: similar documents

(herein after “iMDK” (Compound A, below) was purchased from ChemDiv (San Diego, Calif.

COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING CELL OR TISSUE NECROSIS SPECIFICALLY TARGETING CATHEPSIN C AND/OR CELA1 AND/OR CELA3A AND/OR STRUCTURALLY RELATED ENZYMES THERETO

Ilana Nathan [IL]; Boris Khalfin [IL]

Publication date: 2021-10-07 | Patent publication No.: US-20210309620-A1 | Assignees: Ela Pharma Ltd [IL] | IPC: C07D265/22; A61K31/4178; A61K31/426; A61K31/454; C07D277/42; C12N15/113; A61K31/00; A61K31/496; A61K31/415; C07D405/06; C07D277/56; A61K31/4439; C07D233/44; C07D417/12; A61K31/4196; A61K31/4045; A61P25/00; A61K31/167; A61K31/428; A61K31/536; A61K45/06; C07C233/24; C07D233/48; C07D275/06; C12N5/077 | Oldest priority date: 2015-04-07 | Publication date: 2021-10-07

Score: 15.95058 | Text size: 243527 | Find: similar documents

All the compounds disclosed in Table 1 hereinabove were purchased from ChemDiv, San Diego, Calif. ... 3D Structure Similarities and Topological Analogs The following compounds were prepared by vendor ChemDiv Inc. (San Diego, USA) and their respective ChemDiv I.D. numbers are shown in Table 4 below.

NOVEL BICYCLIC OR TRICYCLIC HETEROCYCLIC COMPOUND

Okuyama, Masahiro [JP]; Fukunaga, Kenji [JP]; Usui, Kenji [JP]; Hayashi, Norimitsu [JP]; Iijima, Daisuke [JP]; Horiuchi, Hideki [JP]; Itagaki, Noriaki [JP]

Publication date: 2021-10-06 | Patent publication No.: EP-3683222-B1 | Assignees: Mitsubishi Tanabe Pharma Corporation [JP] | IPC: C07D513/04; C07D471/04; C07D487/04; C07D513/14; A61K31/437; A61K31/5025; A61K31/519; A61K31/5377; A61P25/00; A61P25/18; A61P25/24; A61P25/28; A61P43/00 | Oldest priority date: 2014-04-23 | Publication date: 2021-10-06

Score: 6.4525156 | Text size: 1112016 | Find: similar documents

sold by plural companies (e.g., AKos Consulting & Solutions GmbH, Ambinter, Aurora Fine Chemicals, ChemDiv, Inc.). However, a KAT-II inhibitory action and other pharmacological activities of these compounds have

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Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators

Sara Buhrlage [US]; Ellen Weisberg [US]; James D. Griffin [US]

Publication date: 2021-10-05 | Patent publication No.: US-11136409-B2 | Assignees: Dana-Farber Cancer Institute, Inc. [US] | IPC: A61P31/00; C07K16/30; A61P35/02; C12Q1/6886; G01N33/50; G01N33/574; A01K67/027; C12Q1/02; C12Q1/6806; C12Q1/6841; C12Q1/6851; C12Q1/686; A61K45/06 | Oldest priority date: 2016-09-20 | Publication date: 2021-10-05

Score: 8.066998 | Text size: 446194 | Find: similar documents

HBX19818 analogs were purchased from ChemDiv and dissolved in DMSO to obtain a 10 mM stock solution.

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Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer

Catherine Tachdjian [US]; Donald Karanewsky [US]; Xiao Qing Tang [US]; Hanghui Liu [US]

Score: 9.562369 | Text size: 467664 | Find: similar documents

other well known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego, Calif.

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Small-molecule UT-A-selective urea transport inhibitors

Alan S. Verkman [US]; Cristina Esteva-Font [US]

Publication date: 2021-09-21 | Patent publication No.: US-11123340-B2 | Assignees: The Regents of the University of California [US] | IPC: A61K31/4709; A61K31/425; A61K31/426; A61K31/427; A61K31/47 | Oldest priority date: 2014-05-09 | Publication date: 2021-09-21

Score: 15.755042 | Text size: 143988 | Find: similar documents

screening was done using a collection of 50,000 chemically diverse, drug-like compounds from ChemDiv (San Diego, Calif.). For analysis of structure-activity relationships, >300 commercially available analogs (ChemDiv and Asinex, Winston-Salem, N.C.) were tested.

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INHIBITORS OF HSP70 PROTEINS

SHI, Taoda [US]; CHAPMAN, Eli [US]; AMBROSE, Andrew J. [US]

Publication date: 2021-09-16 | Patent publication No.: WO-2021183942-A1 | Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA [US] | IPC: A61K31/16; A61K31/165; A61K31/166; C07C233/00; C07C233/04; C07C233/06 | Oldest priority date: 2020-03-13 | Publication date: 2021-09-16

Score: 13.077378 | Text size: 122356 | Find: similar documents

1, N-(3-methyl-l-oxo-l-(thiazol-2-ylamino)butan-2-yl)thiophene-2- carboxamide, was purchased from ChemDIV Inc. (San Diego, CA).

INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF

Gary E. Schiltz [US]; Daniela E. Matei [US]; Purav Vagadia [US]

Publication date: 2021-09-09 | Patent publication No.: US-20210276960-A1 | Assignees: Northwestern University [US]; United States Goverment as represented by the Department of Veterans Affairs [US] | IPC: C07D239/48; A61P35/00; C07D239/42; C07D401/12; C07D403/12; C07D409/12 | Oldest priority date: 2020-03-04 | Publication date: 2021-09-09

Score: 18.463318 | Text size: 190284 | Find: similar documents

To this end, we completed a high throughput screening (HTS) campaign of compounds in the ChemDiv library by using a newly developed AlphaLISA assay that robustly measured the TG2/FN complex ... We had previously reported TG53 as a lead inhibitor selected from high throughput screening of the ChemDiv library using an Alpha-Lisa assay (13). ... the TG2-FN complex formation and were discovered through AlphaLISA based HTS applied to the ChemDiv library11. ... Discovery of TG2/FN inhibitors—HTS using the ChemDiv library: Next, the ChemDiv library containing 10,000 diverse compounds arrayed at 10 μM each was screened using the assay

CORONA VIRUS BINDERS

SCHEPENS, Bert [BE]; SAELENS, Xavier [BE]; CALLEWAERT, Nico [BE]; DE VLIEGER, Dorien [BE]; VAN SCHIE, Loes [BE]; NERINCKX, Wim [BE]; ROOSE, Kenny [BE]; VAN BREEDAM, Wander [BE]; EECKHAUT, Hannah [BE]; FIJALKOWSKA, Daria [BE]; LONIGRO, Chiara [BE]; DE CAE, Sieglinde [BE]; DOMBRECHT, Bruno [BE]; STORTELERS, Catelijne [BE]; NEYTS, Johan [BE]; DELANG, Leen [BE]; KAPTEIN, Suzanne [NL]; DUARTE DA ROCHA PEREIRA, Joana [BE]; GRAHAM, Barney [US]; MCLELLAN, Jason [US]; WRAPP, Daniel [US]; REMAUT, Han [BE]

Publication date: 2021-08-12 | Patent publication No.: WO-2021156490-A2 | Assignees: VIB VZW [BE]; UNIVERSITEIT GENT [BE]; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US]; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US]; TRUSTEES OF DARTMOUTH COLLEGE [US]; KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D [BE]; EXEVIR BIO BV [BE]; VRIJE UNIVERSITEIT BRUSSEL [BE] | IPC: A61K39/215 | Oldest priority date: 2020-02-06 | Publication date: 2021-08-12

Score: 9.562369 | Text size: 377714 | Find: similar documents

from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Flungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands), ZINC15 (Univ. of California).

CFTR regulators and methods of use thereof

Alan S. Verkman [US]; Marc H. Levin [US]; Onur Cil [US]; Mark J. Kurth [US]

Publication date: 2021-08-10 | Patent publication No.: US-11084795-B2 | Assignees: The Regents of the University of California [US] | IPC: C07D241/44; C07D401/06; C07D405/06; C07D409/06; C07D403/04; C07D405/04; C07D498/06; C07D409/04 | Oldest priority date: 2015-12-24 | Publication date: 2021-08-10

Score: 15.528575 | Text size: 764864 | Find: similar documents

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USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE

David J. Dowling [US]; Ofer Levy [US]; Francesco Borriello [US]; David A. Scott [US]; Spencer E. Brightman [US]

Publication date: 2021-08-05 | Patent publication No.: US-20210236632-A1 | Assignees: Children's Medical Center Corporation [US]; Dana-Farber Cancer Institute, Inc. [US] | IPC: A61K39/39; A61K45/06; A61K31/739; A61K31/4535; A61K31/381; A61K31/496; A61K31/438; A61K31/4025 | Oldest priority date: 2018-07-27 | Publication date: 2021-08-05

Score: 12.211837 | Text size: 385572 | Find: similar documents

USING MICRORNAS TO CONTROL ACTIVATION STATUS OF HEPATIC STELLATE CELLS AND TO PREVENT FIBROSIS IN PROGRESSIVE LIVER DISEASES

Michael Yoonsuk CHOI [US]; Byeong-Moo KIM [US]

Score: 11.227331 | Text size: 200752 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

PAK1 inhibitors and uses thereof

Ulrich Steidl [US]; Ashley M. Eckel [US]; Robert F. Stanley [US]; Boris Rogovoy [US]; Ilya Okun [US]

Score: 14.153812 | Text size: 70668 | Find: similar documents

Compounds were screened for PAK1 inhibition using a 50,024 compound library by ChemDiv (San Diego, Calif.

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SWEET FLAVOR MODIFIER

TACHDJIAN, Catherine [US]; KARANEWSKY, Donald [US]; WERNER, Sara [US]; DARMOHUSODO, Vincent [US]; YAMAMOTO, Jeff [US]

Score: 11.477125 | Text size: 221700 | Find: similar documents

other well known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, PA, ChemDiv of San Diego, CA, Chembridge of San Diego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the

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INHIBITION OF FOLLISTATIN

Gerard M. Housey [US]; Monica E. Balash [US]

Score: 12.297968 | Text size: 156156 | Find: similar documents

and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-XInfinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,

SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCER TYPES

Luke L. Lairson [US]; Michael J. Bollong [US]; Peter G. Schultz [US]; Sendurai A. Mani [US]

Publication date: 2021-07-01 | Patent publication No.: US-20210196713-A1 | Assignees: The Scripps Research Institute [US]; Board of Regents, The University of Texas System [US] | IPC: A61K31/502; A61K31/437; A61K31/4704; A61K31/4741; A61K31/497; A61K31/4985; A61K31/551; A61P35/00 | Oldest priority date: 2017-10-30 | Publication date: 2021-07-01

Score: 16.51147 | Text size: 107793 | Find: similar documents

Selected hit compounds were reordered from ChemDiv and tested for selective toxicity in 10-point response assays as above. ... a library of ̃50,000 diverse heterocyclic compounds and biologically active small molecules (ChemDiv, San Diego, Calif., USA) for cytotoxic activity against both cell lines.

CELLS EXPRESSING APOLIPOPROTEIN E AND USES THEREOF

LINDQUIST, Susan L. [US]; NARAYAN, Priyanka [US]

Score: 7.592094 | Text size: 433990 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

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Cellular discovery platform for neurodegenerative diseases

Susan L. Lindquist [US]; Vikram Khurana [US]; Chee-Yeun Chung [US]

Score: 7.1699963 | Text size: 565577 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

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SELECTIVE CALCIUM CHANNEL ANTAGONISTS

Dalton J. Surmeier, Jr. [US]; Richard B. Silverman [US]; Soo Sung Kang [US]; Garry Cooper [US]

Score: 13.245268 | Text size: 99718 | Find: similar documents

to screen 60,480 commercial compounds (ADSI set 6,800; ChemBridge diverse/lead like set 20,000; ChemDiv diverse set 30,000; NIH clinical trial set 480, NCl/DTP set 3,200).

COMPOSITIONS FOR TREATMENT OF FIBROSIS

TWEARDY, David, J. [US]; KASEMBELI, Moses, M. [US]; XU, Marvin, X. [CN]; AGARWAL, Sandeep, K. [US]; PEDROZA, Mesias [US]

Publication date: 2021-06-23 | Patent publication No.: EP-3021839-B1 | Assignees: Baylor College Of Medicine [US] | IPC: A61K31/18; A61K31/05; A61K31/4196; A61K45/06; A61P17/02; A61P35/00; A61K31/343; A61K31/39; A61P19/04 | Oldest priority date: 2013-07-18 | Publication date: 2021-06-23

Score: 15.999366 | Text size: 142511 | Find: similar documents

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ALDH3A2 INHIBITION AND FERROPTOSIS INDUCTION FOR CANCER THERAPY

CHATTOPADHYAY, Shrikanta [US]; YUSUF, Rushdia [US]; VAN GASTEL, Nick [BE]; SHARDA, Azeem, S. [US]; SAEZ, Borja [ES]; VISWANATHAN, Vasanthi, S. [US]; SCADDEN, David, T. [US]

Publication date: 2021-06-17 | Patent publication No.: WO-2021119215-A1 | Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]; THE BROAD INSTITUTE, INC. [US]; THE GENERAL HOSPITAL CORPORATION [US] | IPC: A61P35/00; C12N9/04; A61K45/06 | Oldest priority date: 2019-12-09 | Publication date: 2021-06-17

Score: 10.988179 | Text size: 199135 | Find: similar documents

The initial screen will be performed on the ChemDiv 6 library, a select set of 44,000 public domain compounds.

AGONISTS OF RNA ADENOSINE N-6 METHYLATION FOR USE IN SUPPRESSING HIV-1 LATENT PROVIRUS ACTIVATION AND REPLICATION

SELBERG, Simona [EE]; ŽUSINAITE, Eva [EE]; MERITS, Andres [EE]; SELI, Neinar [EE]; KARELSON, Mati [EE]

Score: 14.9756 | Text size: 35975 | Find: similar documents

Methyl piperazine-2-carboxylate (IX) (ChemDiv, Inc., Catalog Number: FF20-0374, Purity > 90%). Ethyl 2-oxopiperidine-3-carboxylate (X) (Enamine, Ltd.

COMPOUNDS AND THEIR USE FOR THE TREATMENT OF α1-ANTITRYPSIN DEFICIENCY

RAMSDEN, Dr. Nigel [GB]; FOX, Dr. David John [GB]; HUNTINGTON, Prof. James Andrew [GB]; TOMLINSON, Dr. James Michael [GB]

Publication date: 2021-06-17 | Patent publication No.: WO-2021116703-A1 | Assignees: Z FACTOR LIMITED [GB] | IPC: A61P1/16; A61P11/00; A61P35/00; C07D207/48; C07D211/96; C07D401/12; A61K31/40; A61K31/445; A61K31/4709 | Oldest priority date: 2019-12-13 | Publication date: 2021-06-17

Score: 15.196177 | Text size: 41754 | Find: similar documents

This compound is listed as commercially available from Aurora, ChemDiv and the FCH Group but no publications are recorded.

ALPHA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

Iwao Ojima [US]; Dale Deutsch [US]; Martin Kaczocha [US]; Kongzhen Hu [US]; Simon Tong [US]; Matthew Elmes [US]; Su Yan [US]

Publication date: 2021-06-17 | Patent publication No.: US-20210179535-A1 | Assignees: The Research Foundation for The State University of New York [US] | IPC: C07C69/753; C07C69/757; C07C205/55; C07D249/06; C07D309/06; C07C233/25; C07C61/04; C07D215/06 | Oldest priority date: 2016-03-11 | Publication date: 2021-06-17

Score: 13.077378 | Text size: 120610 | Find: similar documents

Competitors included arachidonic acid, BMS309403, 48 test compounds from ChemDiv library, Compound 26 and Compound 49.

SMALL MOLECULE INHIBITORS OF VOLTAGE-GATED SODIUM CHANNEL 1.7 AND METHODS OF USING SAME

BORTSOV, Andrey [US]; CHANDRA, Sharat [US]; JI, Ru-Rong [US]

Score: 19.189526 | Text size: 136261 | Find: similar documents

For virtual screening, a database of 1.5 million compounds was downloaded from the Chemdiv website (chemdiv.com, ChemDiv Inc., San Diego, CA). ... A similarity threshold value of 0.5 against the compounds from the Chemdiv database was used to screen for potential Navi.7 inhibitors. ... Similarity search of the ChemDiv database (ChemDiv Inc, San Diego, CA) containing 1.5 million pre- synthetized compounds yielded a set of 2000 compounds ... and sufficient quantity (1 mg or more) available in stock were selected and purchased from ChemDiv for in vitro and in vivo activity assessment. [0139] Patch-clamp recordings of Navl.

SMALL MOLECULES AGAINST CEREBLON TO ENHANCE EFFECTOR T CELL FUNCTION

Pearlie Burnette [US]; Harshani Lawrence [US]; Nicholas J. Lawrence [US]

Publication date: 2021-06-17 | Patent publication No.: US-20210177825-A1 | Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: A61K31/4545; A61K31/454; A61K31/517; A61K31/513; A61K31/404; A61K31/45; A61K31/4725; A61K31/4525; A61K31/4015; A61K31/5377; A61K31/50; A61K31/4523 | Oldest priority date: 2016-03-16 | Publication date: 2021-06-17

Score: 8.605278 | Text size: 476034 | Find: similar documents

32,000 compounds LifeChemicals 6000 compounds NCl fucused collections 4,000 compounds ChemDiv 30,000 compounds Chembridge 60,000 compounds Kinase libraries.

Methods and compositions for treating mesothelioma and small lung cancer that express midkine

Jeffrey A. Whitsett [US]; Yutaka Maeda [US]; Takuya Fukazawa [JP]

Publication date: 2021-06-08 | Patent publication No.: US-11026950-B2 | Assignees: Children's Hospital Medical Center [US] | IPC: A61K31/5377; A61K31/429; A61P35/00; A61K31/4427; A61K31/4375; A61K31/444 | Oldest priority date: 2016-07-28 | Publication date: 2021-06-08

Score: 14.656486 | Text size: 56241 | Find: similar documents

(herein after “iMDK” (Compound A, below) was purchased from ChemDiv (San Diego, Calif.

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α- and γ-truxillic acid derivatives and pharmaceutical compositions thereof

Iwao Ojima [US]; Dale Deutsch [US]; Martin Kaczocha [US]; William T. Berger [US]; Robert Rizzo [US]; Trent E. Balius [US]

Publication date: 2021-06-08 | Patent publication No.: US-11026910-B2 | Assignees: The Research Foundation for The State University of New York [US] | IPC: A61K31/216; C07C67/08; C07C211/58; C07C233/11; C07C233/58; C07C235/38; C07C235/40; C07C69/753; C07C69/76; C07C67/48; C07C69/757; G01N33/566; A61K31/194; G01N33/68 | Oldest priority date: 2012-07-20 | Publication date: 2021-06-08

Score: 19.70499 | Text size: 144954 | Find: similar documents

Energetically DOCK selected ligands from the ChemDiv library that did not have unfavorable interaction, both VDW and ES, intrinsically selecting ... The following compounds are available from ChemDiv (San Diego, Calif., USA): StructureChemDiv ID Number [[image:EMI-C00036]] 8009-2334 [[image:EMI-C00037]] 8009-3434 [[image:EMI-C00038]] ... acid was from Cayman Chemical (Ann Arbor, Mich.). 48 virtually screened test compounds from ChemDiv, Inc. (Moscow, Russia). ... Competitors included arachidonic acid, BMS309403, 48 test compounds from ChemDiv library, Compound 26 and Compound 49. ... Virtual Screening A high-throughput virtual screening of over one million molecules from the ChemDiv subset of the ZINC database (http://zinc.docking.

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RIG-I INNATE IMMUNE RECEPTOR ANTAGONISTS AND METHODS OF USING SAME

PYLE, Anna, Marie [US]; RAWLING, David [US]; JAGDMANN, G., Erik [US]; POTAPOVA, Olga [US]

Score: 13.077378 | Text size: 123000 | Find: similar documents

11 libraries, including the ChemBridge, Enzo Kinase Inhibitor, Enzo Phosphatase Inhibitor, ChemDiv and Nuclear Receptor Libraries, was screened.

LYMPHOCYTE ANTIGEN CD5-LIKE (CD5L) MONOMER, HOMODIMER, AND INTERLEUKIN 12B (P40) HETERODIMER AGONISTS AND METHODS OF USE THEREOF

Vijay K. Kuchroo [US]; Chao Wang [US]; Aviv Regev [US]

Publication date: 2021-05-13 | Patent publication No.: US-20210139601-A1 | Assignees: The Broad Institute, Inc. [US]; The Brigham and Women's Hospital, Inc. [US]; Massachusetts Institute of Technology [US] | IPC: C07K16/28; C07K14/705; A61K38/17; A61K39/395; A61K45/06; A61P35/00 | Oldest priority date: 2017-05-25 | Publication date: 2021-05-13

Score: 6.7923617 | Text size: 634947 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

COMPOSITIONS AND METHODS FOR INHIBITING GROUP II INTRON RNA

Anna Pyle [US]; Olga Fedorova [US]; Erik Gunnar Jagdmann [US]; Michael Van Zandt [US]; Lin Yuan [US]; Albert DeBerardinis [US]

Publication date: 2021-05-13 | Patent publication No.: US-20210139512-A1 | Assignees: YALE UNIVERSITY [US] | IPC: C07F5/02; C07D307/83; C07D307/80; C07C233/73; C07D405/04; C07D277/26; C07D405/12; C07C243/38; C07D307/52; C07D239/26; C07C49/84; C07C233/65; C07D217/04; C07D207/08; C07D211/16; C07D413/04; C07D233/64; C07D277/24; C07D295/192; C07D277/66; C07D295/215; A61P31/10 | Oldest priority date: 2018-01-26 | Publication date: 2021-05-13

Score: 10.328181 | Text size: 285136 | Find: similar documents

(76 compounds), protease inhibitors (53 compounds) and additional compounds from ChemBridge MW and ChemDiv to bring the total number of compounds to 10000. The D135 ribozyme (Su et al.

INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS

Sanjay A. Desai [US]; Ajay D. Pillai [IN]

Publication date: 2021-04-29 | Patent publication No.: US-20210121476-A1 | Assignees: The United States of America,as represented by the Secretary,Department of Health and Human Services [US] | IPC: A61K31/553; A61K31/165; A61K31/4155; A61K31/423; A61K31/4245; A61K31/433; A61K31/4355; A61K31/437; A61K31/4439; A61K31/4741; A61K31/4745; A61K31/50; A61K31/554; A61K45/06; C07D403/08; C07D498/04; C07D263/57; C07D281/16; C07D413/14; C07D417/06; C07D491/048; C07D513/04; A61K31/421 | Oldest priority date: 2008-07-23 | Publication date: 2021-04-29

Score: 14.451191 | Text size: 51257 | Find: similar documents

methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England.

FERROCHELATASE INHIBITORS AND METHODS OF USE

Timothy W. CORSON [US]; Kamakshi SISHTLA [US]; Seung-Yong SEO [KR]; Bit LEE [KR]

Publication date: 2021-04-29 | Patent publication No.: US-20210121465-A1 | Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US]; Gachon University of Industry-Academic Cooperation [KR] | IPC: A61K31/519; A61K41/00; A61K38/17; A61K39/395; A61K31/4025; A61K31/4706; A61K31/49; A61K31/37; A61K31/4709; A61K31/122; A61K31/155; A61K31/409; A61K31/343; C12N15/113; A61K45/06; C07D487/04; C07D249/14; A61P27/02; A61K31/4196; C07K16/22 | Oldest priority date: 2018-04-30 | Publication date: 2021-04-29

Score: 15.999366 | Text size: 141607 | Find: similar documents

at the Indiana University School of Medicine Chemical Genomics Core Facility (CGCF) using the ChemDiv 10K and a portion (10,000 compounds) of the ChemBridge 50K libraries of chemical compounds. ... IC50 Determination Compounds, reordered from ChemDiv or synthesized as described above, were made to 10 mM in DMSO and tested in the FECH enzymatic

REACTIVE AFFINITY PROBE-INTERACTION DISCOVERY PLATFORM

LABENSKI, Matthew, T. [US]; RETTENMAIER, Terry, J. [US]; JONES, Lyn, H. [US]; MUNCIPINTO, Giovanni [US]

Score: 14.656486 | Text size: 52535 | Find: similar documents

for example, from Enzo Life Sciences, Aurora Fine Chemicals, Exclusive Chemistry Ltd., ChemDiv, ChemBridge, TimTec Inc., AsisChem, and Princeton Biomolecular Research, among others.

RESPIRATORY AND SWEAT GLAND IONOCYTES

Jayaraj Rajagopal [US]; Aviv Regev [US]; Moshe Biton [US]; Adam Haber [US]; Daniel Montoro [US]; Orit Rozenblatt-Rosen [US]

Publication date: 2021-04-22 | Patent publication No.: US-20210115407-A1 | Assignees: The Broad Institute, Inc. [US]; The General Hospital Corporation [US]; Massachusetts Institute of Technology [US] | IPC: C12N5/071; A61K35/42; A61P11/00; G01N33/50 | Oldest priority date: 2017-04-12 | Publication date: 2021-04-22

Score: 7.592094 | Text size: 511847 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM among others.

INHIBITORS OF HIV-1 INTEGRASE MULTIMERIZATION

Mark D. Andrake [US]; Anna Marie Skalka [US]; George W. Merkel [US]

Publication date: 2021-04-22 | Patent publication No.: US-20210113570-A1 | Assignees: Institute for Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center [US] | IPC: A61K31/53; A61K31/4245; A61K31/454 | Oldest priority date: 2017-01-26 | Publication date: 2021-04-22

Score: 17.199627 | Text size: 51249 | Find: similar documents

formation (see FIG. 1B), and used it to screen the 50,000 compound chemical diversity library of ChemDiv, ltd. at 10 uM concentration. ... day were performed to screen the entire Chemical Diversity set of 50,000 compounds obtained from ChemDiv, Ltd.

NATURAL SWEETENER COMPOSITIONS

Anandasankar RAY [US]; Sean Michael BOYLE [US]

Score: 12.913692 | Text size: 221423 | Find: similar documents

other well-known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego, Calif.

METHODS FOR DETECTING PROTEIN-PROTEIN INTERACTIONS

CABANTOUS, Stéphanie [FR]; KORAÏCHI, Faten [FR]; FAVRE, Gilles [FR]

Publication date: 2021-04-21 | Patent publication No.: EP-3314260-B1 | Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale) [FR]; Université Paul Sabatier Toulouse III [FR] | IPC: G01N33/542; G01N33/68 | Oldest priority date: 2015-09-30 | Publication date: 2021-04-21

Score: 13.077378 | Text size: 128423 | Find: similar documents

It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.

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SMALL MOLECULE INHIBITORS OF Id PROTEINS

BENEZRA, Robert [US]; OUERFELLI, Ouathek [US]

Publication date: 2021-04-08 | Patent publication No.: WO-2021067393-A1 | Assignees: MEMORIAL SLOAN KETTERING CANCER CENTER [US] | IPC: A61K31/131; A61K31/135; A61K31/137; C07C211/01; C07C211/03; C07C211/08 | Oldest priority date: 2019-10-01 | Publication date: 2021-04-08

Score: 10.759004 | Text size: 240527 | Find: similar documents

Compiled lists of commercially available compounds (libraries available from ChemBridge, ChemDiv, Maybridge, and Salor) were screened using a beta release of Autodock 4.0 (The Scripps Research

Substituted thiazoles for preventing and/or treating cell or tissue necrosis

Ilana Nathan [IL]; Boris Khalfin [IL]

Publication date: 2021-04-06 | Patent publication No.: US-10968185-B2 | Assignees: ELA PHARMA LTD. [IL] | IPC: A61K31/427; C07D277/20; C07D265/22; A61K31/4178; A61K31/426; A61K31/454; C07D277/42; C12N15/113; A61K31/00; A61K31/496; A61K31/415; C07D405/06; C07D277/56; A61K31/4439; C07D233/44; C07D417/12; A61K31/4196; A61K31/4045; A61P25/00; A61K31/167; A61K31/428; A61K31/536; A61K45/06; C07C233/24; C07D233/48; C07D275/06; C12N5/077 | Oldest priority date: 2015-04-07 | Publication date: 2021-04-06

Score: 15.95058 | Text size: 246336 | Find: similar documents

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Alpha-truxillic acid derivatives and pharmaceutical compositions thereof

Iwao Ojima [US]; Dale Deutsch [US]; Martin Kaczocha [US]; Kongzhen Hu [US]; Simon Tong [US]; Matthew Elmes [US]; Su Yan [US]

Publication date: 2021-04-06 | Patent publication No.: US-10968163-B2 | Assignees: The Research Foundation for the State University of New York [US] | IPC: C07C69/753; C07C61/04; C07C69/757; C07C205/55; C07D249/06; C07D309/06; C07C233/25; C07D215/06 | Oldest priority date: 2016-03-11 | Publication date: 2021-04-06

Score: 13.077378 | Text size: 127287 | Find: similar documents

Competitors included arachidonic acid, BMS309403, 48 test compounds from ChemDiv library, Compound 26 and Compound 49.

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SMALL MOLECULES FOR DISRUPTING THE SUPER ELONGATION COMPLEX AND INHIBITING TRANSCRIPTION ELONGATION FOR CANCER THERAPY

Ali Shilatifard [US]; Kaivvei Liang [US]; Edwin R. Smith [US]; Gary E. Schiitz [US]; Rama K. Mishra [US]; Kristen Stoltz [US]

Publication date: 2021-04-01 | Patent publication No.: US-20210094907-A1 | Assignees: NORTHWESTERN UNIVERSITY [US] | IPC: C07C235/74; C07C235/78; C07D241/20; C07D213/40; C07D257/06; C07D271/07; C07D277/46; C07D213/75; C07D239/42; C07D261/18; C07D231/14; C07D239/36; A61P35/00 | Oldest priority date: 2018-03-21 | Publication date: 2021-04-01

Score: 15.288118 | Text size: 192069 | Find: similar documents

Based on the structure of KL-1 (FIG. 1C), we performed a KL-1 similarity search with ChemDiv compounds and tested the top 32 most similar compounds. ... The candidate chemicals from the in silico screening were purchased from the vendors ChemDiv, ChemBridge and Enamine. MDA231-LM2 Tumor Model.

PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTION OF MALARIA

Sanjay A. Desai [US]

Publication date: 2021-03-25 | Patent publication No.: US-20210085679-A1 | Assignees: The United States of America,as represented by the Secretary,Department of Health and Human Services [US] | IPC: A61K31/501; A61K31/496; A61K45/06; C07D413/14; C07D409/04; C07D409/14; C07D239/84; C07D417/06; C07D241/44; C07D263/57; C07D491/048; C07D498/04; C07D277/54; C07D513/04; C07D281/16; A61K31/42; A61K31/433; A61K31/495; A61K31/498; A61K31/50; A61K31/519; A61K31/554; C07K14/445; A61K31/422; A61K31/4741; A61K31/517; A61K39/015; C07K16/20; A61K31/423; A61K31/427; A61K31/4355; A61K31/437; A61K31/4439 | Oldest priority date: 2011-04-12 | Publication date: 2021-03-25

Score: 15.755042 | Text size: 131078 | Find: similar documents

methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England. ... room temperature using a commercial library of 50,000 compounds with >90% purity confirmed by NMR (ChemDiv). Screens were performed in 384-well format with individual wells containing a single compound at

USE OF THIAZOLE AMIDE COMPOUNDS FOR MODULATING HUMAN IMMUNE RESPONSE

DOWLING, David J. [US]; LEVY, Ofer [US]; BORRIELLO, Francesco [US]

Score: 12.507937 | Text size: 351345 | Find: similar documents

Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases

Philippe Guedat [FR]; Anne Bertolotti [GB]

Publication date: 2021-03-23 | Patent publication No.: US-10954198-B2 | Assignees: United Kingdom Research and Innovation [GB]; Inflectis Bioscience [FR] | IPC: C07D253/075; A61K31/155; A61K31/44; A61K31/53; C07C281/18; C07D213/61; A61K45/06; A61K31/165; A61K31/216; C07C281/16 | Oldest priority date: 2013-01-10 | Publication date: 2021-03-23

Score: 16.251385 | Text size: 109228 | Find: similar documents

EXAMPLES Methods & Materials Example 1 was purchased from Chemdiv ref: 1683-6588 Example 2 was purchased from Chembridge ref: 5173161 Example 4 was purchased from Enamine ref: Z49562642 Example 6 was purchased from Chemdiv ref: 1683-6502 Preparation of the Compounds According to the Present Invention The reactants and

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Compounds useful as modulators of TRPM8

Chad Priest [US]; Alain Noncovich [US]; Andrew Patron [US]; Jane Ung [US]

Publication date: 2021-03-23 | Patent publication No.: US-10953007-B2 | Assignees: Firmenich Incorporated [US] | IPC: A61K31/381; A61K31/4155; A61K31/497; A23L27/00; C07C233/11; C07C235/20; C07C235/24; C07C235/34; C07D213/40; C07D213/75; C07D231/40; C07D277/28; C07D307/52; C07D333/20; C07D333/24; C07D333/32; C07D405/12; C07D407/12; C07D409/14; C07D413/12; C07D417/12; C07D471/04; A61K8/42; A61K8/49; A61K8/69; A61Q19/00; C07D409/12; A01N43/10; A01N43/40; A01N43/56; A01N43/60; A01N43/76; A01N43/80; A01N43/90; A23L33/10; A01N37/18; A01N43/78; A61K31/165; A61K31/415; A61K31/422; A61K31/426; A61K31/437; A61K31/4409; A61K31/4436; A61Q1/02; A61Q5/02; A61Q5/12; A61Q9/02; A61Q11/00; A61Q15/00; A61Q17/02; A61Q17/04; A61Q19/10 | Oldest priority date: 2010-11-05 | Publication date: 2021-03-23

Score: 19.40844 | Text size: 247612 | Find: similar documents

93 This compound was purchased from Chemdiv. ... 96 This compound was purchased from Chemdiv. ... 109 This compound was purchased from Chemdiv. ... 116 This compound was purchased from Chemdiv. ... 123 This compound was purchased from Chemdiv. ... 128 This compound was purchased from Chemdiv. ... 132 This compound was purchased from Chemdiv. ... 163 This compound was purchased from Chemdiv. ... 166 This compound was purchased from Chemdiv. ... 169 This compound was purchased from Chemdiv.

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NOVEL GENETIC MARKERS FOR POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS) AND METHODS OF USE THEREOF FOR DIAGNOSIS AND TREATMENT OF THE SAME

HAKONARSON, Hakon [US]; QU, Huiqi [US]

Publication date: 2021-03-18 | Patent publication No.: WO-2021050608-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: A01H1/00; A01H5/00; C07K14/415; C07K16/16; C12N1/21; C12N5/10; C12N15/63 | Oldest priority date: 2019-09-09 | Publication date: 2021-03-18

Score: 13.775837 | Text size: 86074 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

COMPOSITIONS COMPRISING RARE GENETIC SEQUENCE VARIANTS ASSOCIATED WITH PULMONARY FUNCTION AND METHODS OF USE THEREOF FOR DIAGNOSIS AND TREATMENT OF ASTHMA IN AFRICAN AMERICAN PATIENTS

HAKONARSON, Hakon [US]; SLEIMAN, Patrick [US]

Score: 13.594319 | Text size: 86771 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

VACUOLIN-1 AS AN INHIBITOR OF AUTOPHAGYAND ENDOSOMAL TRAFFICKING AND THE USE THEREOF FOR INHIBITING TUMOR PROGRESSION

YUE, Jianbo [CN]; LU, Yingying [CN]

Score: 14.656486 | Text size: 53377 | Find: similar documents

Figure 14 shows a virtual screening strategy for vacuolin-1 analogue identification using ChemDiv.

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Inhibitors of HIV-1 integrase multimerization

Mark D. Andrake [US]; Anna Marie Skalka [US]; George W. Merkel [US]

Score: 17.199627 | Text size: 54983 | Find: similar documents

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PYRAZOLE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY

Vladimir L. Katanaev [CH]; Alexey Koval [CH]

Score: 19.328047 | Text size: 81564 | Find: similar documents

Compound Identification A commercial (ChemDiv Inc., San Diego, Calif., US) small molecule library (high-diversity GPCR-targeted compound library containing 1000 compounds selected by ChemDiv focusing on maximizing chemical diversity from the 40′000 GPCR-targeted compound library [see http://www.chemdiv.com, particularly http://www.chemdiv. ... overall chemical (Tanimoto) and substructural (via generalized structure search) similarity in the ChemDiv collection (ca. 1.5 mio compounds). The overall set of similars (ca. ... (106, F2-99) V006-4971 24.1 85.2 26 (108) V012-3790 16.5 72.7 27 (109) V008-3606 14.3 86.5 *ChemDiv library catalogue number Example 2: Structure of Identified Wnt Pathway Inhibitors TABLE 2:

Inhibitors of the plasmodial surface anion channel as antimalarials

Sanjay A. Desai [US]; Ajay D. Pillai [IN]

Publication date: 2021-01-05 | Patent publication No.: US-10881669-B2 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services [US] | IPC: A61K31/00; A61K31/553; A61K31/165; A61K31/4155; A61K31/423; A61K31/4245; A61K31/433; A61K31/4355; A61K31/437; A61K31/4439; A61K31/4741; A61K31/4745; A61K31/50; A61K31/554; A61K45/06; C07D403/08; C07D498/04; C07D263/57; C07D281/16; C07D413/14; C07D417/06; C07D491/048; C07D513/04; A61K31/421 | Oldest priority date: 2008-07-23 | Publication date: 2021-01-05

Score: 14.553114 | Text size: 52320 | Find: similar documents

methods as would be known to those skilled in the art or obtained from commercial sources such as ChemDiv Inc., San Diego, Calif. or Peakdale Molecular Limited, High Peak, England.

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Method to detect activity of a polymerase

Tim Bergbrede [DE]; Nils-Göran Larsson [DE]; Claes Gustafsson [SE]; Maria Falkenberg-Gustafsson [SE]

Publication date: 2021-01-05 | Patent publication No.: US-10883137-B2 | Assignees: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. [DE]; LEAD DISCOVERY CENTER GMBH [DE] | IPC: C12Q1/6818; C12Q1/68; C12Q1/6825; G01N33/542; G01N33/58; C12Q1/48 | Oldest priority date: 2015-05-29 | Publication date: 2021-01-05

Score: 13.077378 | Text size: 111794 | Find: similar documents

in the assay was 4-methyl-5-[2-(pyrimidin-2-ylamino)thiazol-4yl]thiazol-2-amine (available at ChemDiv) and is applied using contact-free acoustic droplet-dispensing (Labcyte Echo®) from 10 mM compound

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AMYLOID BETA EXPRESSION CONSTRUCTS AND USES THEREFOR

HAQUE, Aftabul [US]; LINDQUIST, Susan L. [US]

Score: 12.913692 | Text size: 134804 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

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TARGETING MELANOCORTIN 3 RECEPTOR FOR TREATMENT/PREVENTION OF EATING, METABOLISM, AND/OR EMOTIONAL DISORDERS

CONE, Roger [US]; SWEENEY, Patrick [US]

Score: 11.738287 | Text size: 165775 | Find: similar documents

A screen was performed with a series of 4160 samples from the ChemDiv 100,000 compound diversity set maintained at CCG (Fig. 2D-F).

IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE

Phillip C. Liu [US]; Alla Volgina [US]; Richard Wynn [US]; Nina Zolotarjova [US]; Liangxing Wu [US]; Kaijiong Xiao [US]; Song Mei [US]; Liang Lu [US]; Wenyu Zhu [US]; Yingda Ye [US]; Haisheng Wang [US]; Ding-Quan Qian [US]; Wenqing Yao [US]

Publication date: 2020-12-24 | Patent publication No.: US-20200397893-A1 | Assignees: Incyte Corporation [US] | IPC: A61K39/39; A61P37/00; A61P37/04; A61P35/00; A61K45/06; C07D213/81; C07D263/57; C07D413/06; C07D413/14; C07D471/04; C07D519/00; G01N33/50 | Oldest priority date: 2016-12-22 | Publication date: 2020-12-24

Score: 8.327448 | Text size: 635928 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

PHOSPHATIDYLSERINE DECARBOXYLASE INHIBITORS

BEN MAMOUN, Choukri [US]; HOYER, Denton [US]; PLUMMER, Mark [US]; THEKKINIATH, Jose [US]; VOELKER, Dennis R. [US]; CHOI, Jae-Yeon [US]

Publication date: 2020-12-24 | Patent publication No.: WO-2020257753-A1 | Assignees: YALE UNIVERSITY [US]; NATIONAL JEWISH HEALTH [US] | IPC: G01N21/64; A61K49/00; C12Q1/527; G01N21/63; G01N33/50 | Oldest priority date: 2019-06-20 | Publication date: 2020-12-24

Score: 12.59831 | Text size: 130889 | Find: similar documents

in Humans” Collection (Yale Center for Molecular Discovery), and bioactive collections from ChemDiv, ChemBridge, and Analyticon.

Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria

Sanjay A. Desai [US]

Publication date: 2020-12-22 | Patent publication No.: US-10869865-B2 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Serv [US] | IPC: A61K31/506; A61K31/496; A61K31/501; A61K45/06; C07D413/14; C07D409/04; C07D409/14; C07D239/84; C07D417/06; C07D241/44; C07D263/57; C07D491/048; C07D498/04; C07D277/54; C07D513/04; C07D281/16; A61K31/42; A61K31/433; A61K31/495; A61K31/498; A61K31/50; A61K31/519; A61K31/554; C07K14/445; A61K31/422; A61K31/4741; A61K31/517; A61K39/015; C07K16/20; A61K31/423; A61K31/427; A61K31/4355; A61K31/437; A61K31/4439 | Oldest priority date: 2011-04-12 | Publication date: 2020-12-22

Score: 15.999366 | Text size: 142367 | Find: similar documents

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METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING MICROBIOME DYSREGULATIONS ASSOCIATED WITH CIRCADIAN CLOCK DISRUPTION

Mathias CHAMAILLARD [FR]

Publication date: 2020-12-17 | Patent publication No.: US-20200390740-A1 | Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]; UNIVERSITE DE LILLE [FR]; INSTITUT PASTEUR DE LILLE [FR]; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - [FR] | IPC: A61K31/353; A61K31/277; A61P1/00 | Oldest priority date: 2016-05-20 | Publication date: 2020-12-17

Score: 13.775837 | Text size: 87730 | Find: similar documents

Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (San Diego, Calif.), ChemDiv (San Diego, Calif.), SPECS (Delft, The Netherlands), Timtec (Newark, Del.

METHODS TO IDENTIFY MODULATORS OF ACTIN-BINDING PROTEINS

Adam William Avery [US]; Thomas S. Hays [US]; David D. Thomas [US]; Michael E. Fealey [US]; Robyn T. Rebbeck [US]

Score: 13.245268 | Text size: 112512 | Find: similar documents

and include AM:RI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,

Molecules, compositions and methods for modulation of SIRT6

Haim Yosef Cohen [IL]; Yariv Kanfi [IL]

Score: 19.510805 | Text size: 61276 | Find: similar documents

High Throughput Screening In the primary screening, compounds from a library (ChemDiv Inc.) were tested at a single concentration of 20 micromolar for their potential to modulate SIRT6 ... an internal identifier; column 2 gives the CAS number for the molecule while column 3 shows its ChemDiv ID; column 4 gives the molecular structure; and column 5 shows percent activity of the molecule in ... TABLE 1 # CAS number ChemDiv ID Structure% activity 20 uM% activity Max. conc. ... stereoisomer of molecule 768382-41-8 D715-0284 [[image:EMI-C00003]] 70 195 TABLE 2 # CAS numberChemDiv ID Structure% activity 20 uM% activity 100 uM 1 332173-46-3 2803-0068 [[image:EMI-C00004]] 88 428 2

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Methods for treatment of retinal disease by photoreceptor gene expression modulation

Thomas A. Reh [US]; Paul Nakamura [US]; Sheng Ding [US]

Publication date: 2020-12-01 | Patent publication No.: US-10849904-B2 | Assignees: University of Washington [US]; The J. David Gladstone Institutes, a Teatamentary Trust Established Under the Will of J. David. Gladstone [US] | IPC: A61K31/519; C07D495/04; A61K31/426; A61K9/00; A61P27/02 | Oldest priority date: 2015-03-27 | Publication date: 2020-12-01

Score: 18.309502 | Text size: 64672 | Find: similar documents

(I) is CA8801: [[image:EMI-C00006]] Compounds CA88 and CA8801 are commercially available from ChemDiv (San Diego, Calif. ... (II) is CA9513: [[image:EMI-C00010]] Compounds CA95 and CA9513 are commercially available from ChemDiv (San Diego, Calif. ... Nr2e3 interacting molecules specifically identified herein were obtained commercially from ChemDiv (San Diego, Calif.

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AUTOPHAGY MODULATORS FOR USE IN TREATING CANCER

Melvin L. DePamphilis [US]; Gaurav Sharma [IN]; Juan Jose Marugan [US]; Marc Ferrer [US]; Ajit Roy [US]

Publication date: 2020-11-26 | Patent publication No.: US-20200369649-A1 | Assignees: The United States of America,as represented by the Secretary,Department of Health and Human Services [US] | IPC: C07D403/12; C07D251/54; C07D239/50; A61P35/00 | Oldest priority date: 2017-12-01 | Publication date: 2020-11-26

Score: 12.913692 | Text size: 129680 | Find: similar documents

Materials and Methods Reagents Compounds 1, 4, 5, 3, and 2 (Specs, ChemDiv, Life Chemicals) and Rapamycin (S1039, Selleck Chemicals) were dissolved in dimethyl sulfoxide

PHOTORECEPTOR GENE MODULATOR PHOTOREGULIN 3 FOR TREATMENT OF RETINAL DISEASE

Thomas A. Reh [US]; Paul Nakamura [US]; Andy Shimchuk [US]; Shibing Tang [CN]; Sheng Ding [US]

Publication date: 2020-11-26 | Patent publication No.: US-20200368234-A1 | Assignees: University of Washington [US]; The J. David Gladstone Institutes, a Testamentary Trust Established Under the Will of J David Gladst [US] | IPC: A61K31/517; A61K9/00 | Oldest priority date: 2017-08-10 | Publication date: 2020-11-26

Score: 14.867696 | Text size: 40027 | Find: similar documents

It was initially obtained from ChemDiv and then synthesized and purified in large quantities in the lab after initial screening.

Methods to diagnose and treat attention-deficit, hyperactivity disorder (ADHD)

Joseph Glessner [US]; Josephine Elia [US]; Hakon Hakonarson [US]

Score: 10.759004 | Text size: 259413 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

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TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

Steven Albert Everett [US]; Saraj Ulhaq [GB]

Publication date: 2020-11-19 | Patent publication No.: US-20200360521-A1 | Assignees: University Court of the University of Dundee [GB] | IPC: A61K47/54; A61K31/343; A61K31/352; A61K31/4184; A61K31/428; A61K31/664; C07D307/80; C07D311/16; C07D311/18; C07D405/04; C07D405/12; C07D405/14; C07D407/12; C07D409/12; C07D417/12; C07D487/04; C07D491/22; A61K31/37; A61K31/381; A61K31/513; A61K31/52; A61K31/665 | Oldest priority date: 2009-05-01 | Publication date: 2020-11-19

Score: 16.116692 | Text size: 221424 | Find: similar documents

COMPOUNDS FOR TREATING DENGUE VIRUS INFECTION AND OTHER VIRAL INFECTIONS

Priscilla L. Yang [US]; Wenlong Lian [US]; Nathanael S. Gray [US]; Nicholas Paul Kwiatkowski [US]; Jinhua Wang [US]; Jaebong Jang [KR]

Publication date: 2020-11-19 | Patent publication No.: US-20200360381-A1 | Assignees: Dana-Farber Cancer Institute, Inc. [US]; President and Fellows of Harvard College [US] | IPC: A61K31/5025; A61K31/4045; A61K31/416; A61K31/47; A61K31/277; A61K31/167; A61K31/53; A61P31/16 | Oldest priority date: 2017-05-15 | Publication date: 2020-11-19

Score: 10.759004 | Text size: 297179 | Find: similar documents

about 20,000 compounds at the concentration of 10 μM (Selleck Known Bioactive library) or 5 μg/ml (ChemDiv library) in duplicate were applied in the AlphaScreen based competition assay using automation

LIN28/LET-7 CRYSTAL STRUCTURES, PURIFICATION PROTOCOLS, AND MOLECULAR PROBES SUITABLE FOR SCREENING ASSAYS AND THERAPEUTICS

Piotr SLIZ [US]; Yunsun NAM [US]

Publication date: 2020-11-19 | Patent publication No.: US-20200362350-A1 | Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: C12N15/113; A61K31/7105; A61K45/06; A61K31/7115; A61K31/712; A61K31/713; C07K14/47; A61K47/60; A61K47/64; C07H21/02 | Oldest priority date: 2011-11-09 | Publication date: 2020-11-19

Score: 10.328181 | Text size: 292964 | Find: similar documents

2, Prestwick 2 Collection, MSDiscovery 1, Biomol ICCB Know Bioactives, Asinex 1, ChemBridge 3, ChemDiv 4 and 6, Life Chemicals 1, and Maybridge 4 and 5. These libraries can be screened using the

Compounds and Methods for Treating or Preventing Anterior Segment Ocular Disorders and/or Retinal Degenerations

Mark Fields [US]; Lucian Del Priore [US]; Huey Cai [US]; Denton Hoyer [US]

Score: 16.124392 | Text size: 102942 | Find: similar documents

As used herein, “compound 414” or “YU162779-01” refers to ChemDiv library compound number C325-0414, or a salt, solvate or hydrate thereof, having the formula: [[image:EMI-C00011]] As used herein, “compound 434” or “YU162787-01” refers to ChemDiv library compound number C325-0434, or a salt, solvate or hydrate thereof, having the

COMPOSITIONS AND METHODS FOR USE IN COMBINATION FOR THE TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES

Hakonarson, Hakon [US]; Yun, Rose Li [US]; Keating, Brendan [US]

Score: 9.22053 | Text size: 312243 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

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ISOLATED HUMAN LUNG PROGENITOR CELLS AND USES THEREOF

RAJAGOPAL, Jayaraj [US]; MOU, Hongmei [US]

Publication date: 2020-10-28 | Patent publication No.: EP-2802647-B1 | Assignees: The General Hospital Corporation [US] | IPC: C12N5/071; C12N5/077; A61K35/42; A61P11/00; A61L27/38; A61L27/56; A61L27/58; A61K9/00; G01N33/68 | Oldest priority date: 2012-04-03 | Publication date: 2020-10-28

Score: 10.328181 | Text size: 254262 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

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PURMORPHAMINE AS A SMALL COMPOUND POSITIVE ALLOSTERIC MODULATOR OF SECRETIN RECEPTOR FOR THE TREATMENT OF HYPERTENSION

SINGH, Kailash [CN]; CHOW, Billy Kwok Chong [CN]

Score: 13.245268 | Text size: 113705 | Find: similar documents

available small molecule libraries used include, but not limited to, PubChem, CHEMBL, MolProt, ChemDiv, ChemSpace, NCI open and ZINC.

METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCLE WASTING, MUSCLE WEAKNESS, AND/OR CACHEXIA

David J. Tweardy [US]; Moses M. Kasembeli [US]; Marvin X. Xu [CN]; Thomas Kristian Eckols [US]

Publication date: 2020-10-22 | Patent publication No.: US-20200331880-A1 | Assignees: Baylor College of Medicine [US] | IPC: C07D333/34; A61K31/47; A61K31/4406; A61K31/415; A61K31/381; A61K31/357; A61K31/145; C07D215/36; C07D213/71; C07D231/18; C07D319/18; C07C311/08; C07C311/10; C07C311/13; C07C311/21; C07C311/24; C07C311/29; C07C311/44; C07C323/49; C07C381/06; A61K45/06; A61K31/18; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4196; A61K31/42; A61K31/428; A61K31/45; A61K31/454; A61K31/4704; A61K31/4709; A61K31/513 | Oldest priority date: 2013-07-18 | Publication date: 2020-10-22

Score: 14.233541 | Text size: 272534 | Find: similar documents

25-HYDROXYCHOLESTEROL (25HC), CRYAB AGGREGATION INHIBITOR, IS A NOVEL SENOLYTIC

OHE, Munemichi [JP]; INOUE, Naoki [JP]; LIMBAD, Chandani [US]; DOI, Ryosuke [US]

Score: 8.902286 | Text size: 356441 | Find: similar documents

and real screening services are commercially available from a number of suppliers (see, e.g., ChemDiv (San Diego, CA), and the like).

Immunomodulator compounds and methods of use

Liang Lu [US]; Wenyu Zhu [US]; Ding-Quan Qian [US]; Kaijiong Xiao [US]

Publication date: 2020-10-20 | Patent publication No.: US-10806785-B2 | Assignees: Incyte Corporation [US] | IPC: A61K39/39; A61P37/00; A61P37/04; A61P35/00; A61K45/06; C07D213/81; C07D263/57; C07D413/06; C07D413/14; C07D471/04; C07D519/00; G01N33/50; A61K39/00 | Oldest priority date: 2016-12-22 | Publication date: 2020-10-20

Score: 8.605278 | Text size: 618747 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bio net (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

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PAK1 INHIBITORS AND USES THEREOF

Ulrich Steidl [US]; Ashley M. Eckel [US]; Robert F. Stanley [US]; Boris Rogovoy [US]; Ilya Okun [US]

Score: 14.350686 | Text size: 67504 | Find: similar documents

Compounds were screened for PAK1 inhibition using a 50,024 compound library by ChemDiv (San Diego, Calif.

NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES

GUEDAT, Philippe [FR]

Score: 15.288118 | Text size: 154239 | Find: similar documents

& METHODS Compound 3 was purchased from Chembridge ref: 5173161 Compound 4 was purchased from Chemdiv ref: 0589-0012 Compound 5 was purchased from Chemdiv ref: 1683-6502 1.1 - Preparation of the compounds according to the present invention The reactants

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PLASMINOGEN ACTIVATOR-1 INHIBITORS AND METHODS OF USE THEREOF

LAWRENCE, Daniel, A. [US]; EMAL, Cory [US]; REINKE, Ashley [US]; LI, Shih-Hon [US]; WARNOCK, Mark [US]; ABERNATHY, Gregory [US]

Publication date: 2020-10-14 | Patent publication No.: EP-2914575-B1 | Assignees: The Regents of The University of Michigan [US]; Eastern Michigan University [US] | IPC: C07C233/08; C07C233/05; A61K31/16; A61K31/165; C07C259/06; C07C271/16; C07C275/64; C07C69/84; C07C311/17; C07C311/29; C07D417/04; C07C323/60; C07D261/18; C07C235/34; C07D271/113; C07D277/34; C07C243/26; C07D207/48; C07C251/76; C07D209/08 | Oldest priority date: 2012-10-31 | Publication date: 2020-10-14

Score: 12.297968 | Text size: 143816 | Find: similar documents

Chemical Methodologies Libraries Development (Boston University), Maybridge, Chembridge, ChemDiv, National Cancer Institute-Development Therapeutics Program Library, the Cayman Cannabinoid and

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High-throughput, high-precision methods for detecting protein structural changes in living cells

David D. Thomas [US]; Simon Joseph Gruber [US]; Razvan L. Cornea [US]; Gregory David Gillispie [US]; Kurt C. Peterson [US]; Seth Louis Robia [US]

Publication date: 2020-10-06 | Patent publication No.: US-10794898-B2 | Assignees: Regents of the University of Minnesota [US]; Loyola University Chicago [US] | IPC: G01N33/50; G01N21/64; G01N33/58 | Oldest priority date: 2014-01-17 | Publication date: 2020-10-06

Score: 12.913692 | Text size: 131545 | Find: similar documents

and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,

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MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE

John Schneekloth, JR. [US]; John Simmons [US]; Kenneth Felsenstein [US]; Beverly Mock [US]; Lindsey Saunders [US]; David Calabrese [US]; Elena Leon [US]

Publication date: 2020-10-01 | Patent publication No.: US-20200308128-A1 | Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Servic [US] | IPC: C07D307/84; A61K31/343; A61K31/397; A61K31/4025; A61K31/439; A61K31/4525; A61K31/496; A61K31/5377; A61K31/55; A61K45/06; C07D405/06; C07D471/08 | Oldest priority date: 2015-01-05 | Publication date: 2020-10-01

Score: 17.89937 | Text size: 186723 | Find: similar documents

20,000 unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridge and ChemDiv screening libraries, in addition to dyes and controls, were printed in duplicate onto four slides ... No.Peggy (% c-Myc expression compared to untreated) IC50 1 [[image:EMI-C00030]] Commercial: ChemDiv No. D089-0563 50% (at 10 μM) 7.6 μM 2 [[image:EMI-C00031]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95% viability (at 10 μM) 3 [[image:EMI-C00032]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4 [[image:EMI-C00033]] Commercial: ChemDiv No. ... ChemBridge No. 6238398 69% (at 10 μM) 89% viability (at 10 μM) 12 [[image:EMI-C00041]] Commercial: ChemDiv No. D089-0350 43% (at 10 μM) 3.4 μM 13 [[image:EMI-C00042]] Commercial: Otava Chemical No.

TARGETING THE TLK1/NEK1 AXIS IN PROSTATE CANCER

Arrigo DeBENEDETTI [US]; Siddhant BHOIR [IN]; Vibha SINGH [US]; Javeena HUSSAIN [IN]; Rupesh CHIKHALE [GB]; Richard BRYCE [GB]; Sivapriya KIRUBAKARAN [IN]

Publication date: 2020-10-01 | Patent publication No.: US-20200306258-A1 | Assignees: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College [US] | IPC: A61K31/5415; A61K31/167; A61P35/00 | Oldest priority date: 2019-03-29 | Publication date: 2020-10-01

Score: 12.913692 | Text size: 104561 | Find: similar documents

The inventors have screened the Prestwick Library, partially the ChemDiv, and two proprietary libraries (10,000 compounds) for inhibitors of TLK with a high throughput

METHODS OF PROMOTING CELLULAR MATURATION WITH AMPK ACTIVATORS

MURRY, Charles E. [US]; YANG, Xiulan [US]

Score: 10.759004 | Text size: 227455 | Find: similar documents

for example, from Enzo Life Sciences, Aurora Fine Chemicals, Exclusive Chemistry Ltd., ChemDiv, ChemBridge, TimTec Inc., AsisChem, and Princeton Biomolecular Research, among others.

PROTEOSTASIS REGULATORS

Megan Foley [US]; Bradley Tait [US]; Matthew Cullen [US]

Publication date: 2020-09-24 | Patent publication No.: US-20200299270-A1 | Assignees: Proteostasis Therapeutics, Inc. [US] | IPC: C07D403/06; C07D207/333; C07D207/337; C07D231/12; C07D249/06; C07D263/32; C07D275/02; C07D295/185; C07D333/20; C07D401/06; C07D405/06; C07D471/04; C07D333/22 | Oldest priority date: 2011-05-12 | Publication date: 2020-09-24

Score: 11.738287 | Text size: 208821 | Find: similar documents

Compound A47 (also shown below) was purchased from ChemDiv, San Diego, Calif.

SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)

LIST, Alan F. [US]; WEI, Sheng [US]

Score: 11.477125 | Text size: 168410 | Find: similar documents

ChemBridge Corporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, CA 92121, USA); Life Chemicals (1103 Orange Center Road,

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Methods for detecting protein-protein interactions

Stéphanie Cabantous [FR]; Faten Koraïchi [FR]; Gilles Favre [FR]

Publication date: 2020-09-22 | Patent publication No.: US-10782304-B2 | Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]; UNIVERSITÉ PAUL SABATIER TOULOUSE III [FR] | IPC: G01N33/68; G01N33/542; C07K16/18; C40B30/04; G01N33/50; G01N33/533 | Oldest priority date: 2015-06-24 | Publication date: 2020-09-22

Score: 13.417523 | Text size: 112605 | Find: similar documents

It will be appreciated that there are many suppliers of chemical compounds, including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis, Mo.

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CRYSTAL STRUCTURE OF ATP CITRATE LYASE AND USES THEREOF

SAVVIDES, Savvas [BE]; VERSTRAETE, Kenneth [BE]

Score: 13.594319 | Text size: 106637 | Find: similar documents

from, for example, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest, Hungary) and ChemDiv (San Diego, Calif.), Specs (Delft, The Netherlands).

NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES

Philippe GUEDAT [FR]

Score: 15.288118 | Text size: 155351 | Find: similar documents

& Methods Compound 3 was purchased from Chembridge ref: 5173161 Compound 4 was purchased from Chemdiv ref: 0589-0012 Compound 5 was purchased from Chemdiv ref: 1683-6502 1.1—Preparation of the Compounds According to the Present Invention The reactants

Materials and method for inhibiting replication protein A and uses thereof

John J. Turchi [US]

Publication date: 2020-09-15 | Patent publication No.: US-10774063-B2 | Assignees: Indiana University Research and Technology Corporation [US] | IPC: C07D401/04; A61P35/00; C07D403/04; C07D231/06; A61K45/06; A61K47/26; A61K47/38; C07D401/14; C07D413/14; A61K9/00 | Oldest priority date: 2014-11-13 | Publication date: 2020-09-15

Score: 13.775837 | Text size: 80367 | Find: similar documents

Chemical compounds, either purchased from ChemDiv or synthesized in the laboratory, were suspended in DMSO and titrated as detailed in each figure.

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ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME

Dan THEODORESCU [US]; Michael Fitzpatrick WEMPE [US]; David ROSS [US]; Chao YAN [US]; Phillip REIGAN [US]

Publication date: 2020-08-13 | Patent publication No.: US-20200255442-A1 | Assignees: The Regents of the University of Colorado, a body corporate [US] | IPC: C07D491/052; A61K31/4162; A61P35/04; A61K45/06 | Oldest priority date: 2014-07-10 | Publication date: 2020-08-13

Score: 12.297968 | Text size: 143369 | Find: similar documents

The ChemDiv library [v2006.

BENZYLIDENEGUANIDINE DERIVATIVES AND THERAPEUTIC USE FOR THE TREATMENT OF PROTEIN MISFOLDING DISEASES

GUEDAT, Philippe [FR]; BERTOLOTTI, Anne [GB]

Publication date: 2020-08-12 | Patent publication No.: EP-3115357-B1 | Assignees: United Kingdom Research and Innovation [GB]; InFlectis BioScience [FR] | IPC: C07C281/18; C07D253/075; C07D213/61; A61K31/155; A61K31/165; A61K31/216; A61K31/44; A61K31/53; A61K45/06; A61P3/10; A61P25/00; A61P25/16; A61P25/28; A61P35/00 | Oldest priority date: 2013-01-10 | Publication date: 2020-08-12

Score: 16.251385 | Text size: 108206 | Find: similar documents

EXAMPLES Methods & Materials Example 1 was purchased from Chemdiv ref: 1683-6588 Example 2 was purchased from Chembridge ref: 5173161 Example 4 was purchased from Enamine ref: Z49562642 Example 6 was purchased from Chemdiv ref: 1683-6502 Preparation of the compounds : used in the present invention The reactants and

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Inhibitors of RAD52 recombination protein and methods using same

Alexander V. Mazin [US]

Publication date: 2020-08-11 | Patent publication No.: US-10738061-B2 | Assignees: Drexel University [US] | IPC: A61P35/00; A61K31/4188; A61K31/5377; A61K31/4741; A61K45/06; A61K31/55; A61K31/47; A61K31/4525; A61K31/496; A61K31/517; C07D491/056; C07D491/048; C07D471/04; C07D307/82; C07D495/04; C07D405/12; C07D239/95; C07D215/38 | Oldest priority date: 2015-06-04 | Publication date: 2020-08-11

Score: 12.59831 | Text size: 134936 | Find: similar documents

The compounds for confirmation analysis were purchased from Asinex Ltd., ChemBridge Co., ChemDiv Inc, Enamine, FCH Group, Frontier Scientific Services Inc., InterBioScreen Ltd., Life Chemicals Inc.

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PHARMACEUTICAL COMPOSITION FOR TREATING THYROID CANCER COMPRISING TYROSINE KINASE ACTIVITY INHIBITOR AS ACTIVE INGREDIENT

Byeong Cheol AHN [KR]; Ji Min OH [KR]

Score: 14.9756 | Text size: 40797 | Find: similar documents

Among the TKI candidates, TKI-0266 was selected, purchased from Chemdiv (USA), dissolved in DMSO, and then stored at −80° C. 5. Protein Isolation and Western

COMBINATIONS, NANOPARTICLES AND METHODS FOR CONTROLLING NATURAL KILLER CELL ACTIVATION AND FUNCTION

BARDA-SAAD, Mira [IL]

Score: 8.902286 | Text size: 338346 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Ft, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

PYRAZOLOPYRIMIDINE MODULATORS OF RAS GTPASE

GARLAND, William A. [US]; UNGASHE, Solomon B. [US]; YANOFSKY, Stephen D. [US]; LIAW, Philip [US]; LENNEK, Annie L. [US]

Score: 12.59831 | Text size: 144424 | Find: similar documents

A library of over 16,000 distinct chemicals was purchased from ChemDiv, San Diego, CA.

AMYLOID BETA EXPRESSION CONSTRUCTS AND USES THEREFOR

HAQUE, Aftabul [US]; LINDQUIST, Susan L. [US]

Score: 12.913692 | Text size: 134796 | Find: similar documents

(Graz, Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia), ChemStar (Moscow, Russia), Exclusive

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Use of aldehyde dehydrogenase as biomarker for beta-cell dysfunction and loss

Domenico Accili [US]; Ja Young Kim-Muller [US]

Score: 12.011612 | Text size: 258055 | Find: similar documents

Maybridge HitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds); ChemDiv Combilab and International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds); Mixed

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Pyrazolopyrimidine Modulators of RAS GTPase

William A. Garland [US]; Solomon B. Ungashe [US]; Stephen D. Yanofsky [US]; Philip Liaw [US]; Annie L. Lennek [US]

Score: 12.59831 | Text size: 130836 | Find: similar documents

3 Identification of Structure 1 A library of over 16,000 distinct chemicals was purchased from ChemDiv, San Diego, Calif.

6-AMINO-1,3-DIMETHYL-4-(4-(TRIFLUOROMETHYL)PHENYL)-1,4-DIHYDROPYRANO [2,3-C]PYRAZOLE-5-CARBONITRILE AND RELATED COMPOUNDS AS RAL GTPASE INHIBITORS FOR TREATING CANCER METASTASIS

THEODORESCU, Dan [US]; WEMPE, Michael [US]; ROSS, David [US]; YAN, Chao [US]; REIGAN, Philip [US]

Publication date: 2020-07-29 | Patent publication No.: EP-3686202-A1 | Assignees: The Regents of the University of Colorado, a body corporate [US] | IPC: C07D491/052; A61K31/4162; A61P35/00; A61P35/04 | Oldest priority date: 2014-07-10 | Publication date: 2020-07-29

Score: 12.297968 | Text size: 150328 | Find: similar documents

The ChemDiv library [v2006.

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HUMAN PLURIPOTENT STEM CELL DERIVED ENDOCARDIAL ENDOTHELIUM

Charles E. Murry [US]; Lil Pabon [US]; Nathan Palpant [US]

Score: 10.759004 | Text size: 207588 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

NOVEL BICYCLIC OR TRICYCLIC HETEROCYCLIC COMPOUND

Okuyama, Masahiro [JP]; Fukunaga, Kenji [JP]; Usui, Kenji [JP]; Hayashi, Norimitsu [JP]; Iijima, Daisuke [JP]; Horiuchi, Hideki [JP]; Itagaki, Noriaki [JP]

Publication date: 2020-07-22 | Patent publication No.: EP-3683222-A1 | Assignees: Mitsubishi Tanabe Pharma Corporation [JP] | IPC: C07D513/04; C07D471/04; C07D487/04; C07D513/14; A61K31/437; A61K31/5025; A61K31/519; A61K31/5377; A61P25/00; A61P25/18; A61P25/24; A61P25/28; A61P43/00 | Oldest priority date: 2014-04-23 | Publication date: 2020-07-22

Score: 6.4525156 | Text size: 1029257 | Find: similar documents

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NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI OR SWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF

Publication date: 2020-07-16 | Patent publication No.: US-20200225217-A1 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; A23L27/00; C07F9/655; C07D405/12; A61K47/24; A61K47/22; A61K8/55; A61K8/49; A23L2/56; G01N33/50; C07D307/82; C07D307/79; C07D307/68; C07D307/52; C07D213/40; C07D285/135; C07D209/42; C07D277/64; C07D209/08; C07D275/03; C07D271/12; C07D261/18; C07D417/12; C07D409/12; C07D401/04; C07D333/38; C07D333/24; C07D231/14; C07D217/06; C07D215/48; C07D213/85; C07D213/81; C07D263/56; A23L27/20; G01N33/74; G01N33/566; C07D317/68; C07D307/84; C07C275/34; C07C275/30; C07C235/54; C07C233/65 | Oldest priority date: 2003-08-06 | Publication date: 2020-07-16

Score: 9.562369 | Text size: 325239 | Find: similar documents

offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego CA, Chembridge of San Diego Calif.

XPA INHIBITOR COMPOUNDS AND THEIR USE

John J. TURCHI [US]; Navath GAVANDE [US]; Pamela S. VANDERVERE-CAROZZA [US]

Score: 15.518069 | Text size: 174633 | Find: similar documents

Compound X80 (1) (FIG. 2A) and its commercially available analogs 2-24 were purchased from ChemDiv (San Diego, USA) and AKos GmbH (Steinen, Germany) library with highest purity (≥95%) and prepared ... binding pockets and identify inhibitors with improved potency, we first searched the virtual Chemdiv (San Diego, USA) and AKos GmbH (Steinen, Germany) library for X80 analogs with a criterion of

Therapeutic uses of benzylideneguanidine derivatives for the treatment of proteopathies

Philippe Guedat [FR]

Score: 15.288118 | Text size: 153760 | Find: similar documents

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METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS

CHEN, Beibei [US]; FINKEL, Toren [US]; LIU, Yuan [US]

Publication date: 2020-07-09 | Patent publication No.: WO-2020142748-A1 | Assignees: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US] | IPC: A61K31/519; C07D239/72; A61P25/00 | Oldest priority date: 2019-01-03 | Publication date: 2020-07-09

Score: 14.432653 | Text size: 245570 | Find: similar documents

The following compounds (free base) provided in Table 2 were obtained from commercial sources (ChemDIV, Inc. and Molport, Inc. ... The following compounds shown in Table 4 were purchased from ChemDIV, Inc.

COMPOSITIONS AND METHODS OF TREATMENT USING NICOTINAMIDE MONONUCLEOTIDE

Shin-ichiro Imai [US]; Alessia Grozio [US]

Publication date: 2020-07-09 | Patent publication No.: US-20200215087-A1 | Assignees: Washington University [US] | IPC: A61K31/706; A61K45/06; A61K48/00; A61P3/04; C12N15/86; G01N33/50; G01N33/68 | Oldest priority date: 2017-08-10 | Publication date: 2020-07-09

Score: 11.738287 | Text size: 160101 | Find: similar documents

media contending 0.2% DMSO (vehicle), 20 M EX527 (Cayman chemical, MI) or 20 M STK665401 (ChemDiv, cat #8018-9378; Sociali, G. et al., Eur. J. Med. Chem., 2015, 102, 530-539).

Materials for cathepsin B enhancement and methods of use

Ben A. Bahr [US]

Publication date: 2020-07-07 | Patent publication No.: US-10702571-B2 | Assignees: The University of North Carolina at Pembroke [US] | IPC: A61K31/70; A61K31/27; A61K38/05; A61K31/352; C07K5/065; A61K45/06; A61P25/28; A61K9/00 | Oldest priority date: 2015-12-03 | Publication date: 2020-07-07

Score: 12.913692 | Text size: 106619 | Find: similar documents

Z-Phe-Pro-OH is commercially available from ChemDiv Inc. (San Diego, Calif., USA).

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Lin28/let-7 crystal structures, purification protocols, and molecular probes suitable for screening assays and therapeutics

Piotr Sliz [US]; Yunsun Nam [US]

Publication date: 2020-07-07 | Patent publication No.: US-10704049-B2 | Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: C12N15/113; A61K45/06; A61K47/60; C07K14/47; A61K47/64; C07H21/02; A61K48/00; A61K31/7105; A61K31/7115; A61K31/712; A61K31/713 | Oldest priority date: 2011-11-09 | Publication date: 2020-07-07

Score: 10.328181 | Text size: 297420 | Find: similar documents

2, Prestwick 2 Collection, MSDiscovery 1, Biomol ICCB Know Bioactives, Asinex 1, ChemBridge 3, ChemDiv 4 and 6, Life Chemicals 1, and Maybridge 4 and 5. These libraries can be screened using the

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TAF1 inhibitors for the therapy of cancer

Sara Sdelci [AT]; Stefan Kubicek [AT]

Publication date: 2020-07-07 | Patent publication No.: US-10702518-B2 | Assignees: CeMM—Forschungszentrum für Molekulare Medizin GmbH [AT] | IPC: A61K31/4725; A61K31/5517; A61P35/00; C07D413/12; C07D217/26; C07D407/12; C07D401/12; A61K45/06; A61K31/44; A61K31/513; G01N33/50; G01N33/68; G01N33/574; A61K31/4433; A61K31/472; A61K31/22; A61K31/517 | Oldest priority date: 2016-02-15 | Publication date: 2020-07-07

Score: 10.759004 | Text size: 232763 | Find: similar documents

Compounds A2, A3, A4 and A5 were purchased from ChemDiv (San Diego, USA). Synthesis of all other analogs was carried out by Enamine Ltd.

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Methods and compositions for treatment of muscle wasting, muscle weakness, and/or cachexia

David J. Tweardy [US]; Moses M. Kasembeli [US]; Marvin X. Xu [CN]; Thomas Kristian Eckols [US]

Publication date: 2020-06-09 | Patent publication No.: US-10676455-B2 | Assignees: Baylor College of Medicine [US] | IPC: C07D333/34; A61K31/47; A61K31/44; A61K31/194; C07C311/21; C07D215/36; A61K31/4406; A61K31/415; A61K31/381; A61K31/357; A61K31/145; C07D213/71; C07D231/18; C07D319/18; C07C311/08; C07C311/10; C07C311/13; C07C311/24; C07C311/29; C07C311/44; C07C323/49; C07C381/06; A61K45/06; A61K31/18; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4196; A61K31/42; A61K31/428; A61K31/45; A61K31/454; A61K31/4704; A61K31/4709; A61K31/513 | Oldest priority date: 2013-07-18 | Publication date: 2020-06-09

Score: 14.233541 | Text size: 273813 | Find: similar documents

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Anti-cancer compounds targeting Ral GTPases and methods of using the same

Dan Theodorescu [US]; Michael Fitzpatrick Wempe [US]; David Ross [US]; Chao Yan [US]; Phillip Reigan [US]

Publication date: 2020-06-09 | Patent publication No.: US-10676480-B2 | Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate [US] | IPC: C07D491/052; A61K31/4162; A61K45/06; A61P35/04 | Oldest priority date: 2014-07-10 | Publication date: 2020-06-09

Score: 12.59831 | Text size: 162784 | Find: similar documents

The ChemDiv library [v2006.

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Methods and compositions for treating mesothelioma and small lung cancer that express midkine

Takuya Fukazawa [JP]; Jeffrey A. Whitsett [US]; Yutaka Maeda [US]

Publication date: 2020-06-02 | Patent publication No.: US-10668078-B2 | Assignees: Children's Hospital Medical Center [US] | IPC: A61K31/5377; A61K31/429; A61P35/00; A61K31/4427; A61K31/4375; A61K31/444 | Oldest priority date: 2016-07-28 | Publication date: 2020-06-02

Score: 14.656486 | Text size: 55756 | Find: similar documents

(herein after “iMDK” (Compound A, below) was purchased from ChemDiv (San Diego, Calif.

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NETRIN- 1 AND DEPENDENCE RECEPTOR PROTEINS AND METHOD OF USE

Jorg Stetefeld [CA]

Score: 12.913692 | Text size: 130967 | Find: similar documents

and include AMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridge Library, ChemDiv Library, Enamine Library, The Greenpharma Natural Compound Library, Life Chemicals Library,

Non-beta lactam antibiotics

Mayland Chang [US]; Shahriar Mobashery [US]; Edward Spink [GB]; Derong Ding [US]; Sebastian Testero [AR]; Erika Leemans [BE]; Marc Boudreau [US]

Publication date: 2020-05-26 | Patent publication No.: US-10662164-B2 | Assignees: University of Notre Dame du Lac [US] | IPC: A61K31/4245; C07D271/107; C07D413/04; C07D471/04; C07D271/06; C07F9/653 | Oldest priority date: 2014-09-25 | Publication date: 2020-05-26

Score: 15.288118 | Text size: 174083 | Find: similar documents

A library of 1.2 million drug-like compounds from the ChemDiv subset of the ZINC database (Irwin et al., J. Chem. Inf. Model. ... From these, 29 compounds were selected and purchased from ChemDiv for in vitro activity experiments. Syntheses.

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LYMPHOCYTE ANTIGEN CD5LIKE (CD5L) MONOMER, HOMODIMER, AND INTERLEUKIN 12B (P40) HETERODIMER ANTAGONISTS AND METHODS OF USE THEREOF

Aviv Regev [US]; Vijay K. Kuchroo [US]; Chao Wang [US]

Publication date: 2020-05-21 | Patent publication No.: US-20200157237-A1 | Assignees: The Broad Institute, Inc. [US]; Massachusetts Institute of Technology [US]; The Brigham and Women's Hospital, Inc. [US] | IPC: C07K16/28; C07K16/30; C12N15/113; G01N33/50; G01N33/574; G16B50/30; G16H50/70 | Oldest priority date: 2017-05-25 | Publication date: 2020-05-21

Score: 6.7923617 | Text size: 644529 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES

GUEDAT, Philippe [FR]

Score: 15.288118 | Text size: 168703 | Find: similar documents

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COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES

WU, Jay Jie-Qiang [US]

Publication date: 2020-05-20 | Patent publication No.: EP-3135672-B9 | Assignees: VM Discovery, Inc. [US] | IPC: C07D401/14; C07D401/02; C07D279/14; C07D241/40; C07D487/04; C07D265/36; C07D498/04; A61K31/4162; A61P35/00 | Oldest priority date: 2008-10-10 | Publication date: 2020-05-20

Score: 11.738287 | Text size: 207681 | Find: similar documents

Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (San Diego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands), Timtec (Newark, DE) or can be synthesized.

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Small molecule inhibitors of USP1 deubiquitinating enzyme activity

Alan D. D'Andrea [US]; Gregory D. Cuny [US]; Ross L. Stein [US]; Marcie Glicksman [US]; April Case [US]; Jun Xian [US]; David Wilson [US]; Min Huang [CN]

Publication date: 2020-05-19 | Patent publication No.: US-10653676-B2 | Assignees: Dana-Farber Cancer Institute, Inc. [US]; The Brigham and Women's Hospital, Inc. [US] | IPC: A61K31/423; C07D405/06; C07D263/60; A61K31/136; A61K31/472; A61K31/4725; A61K45/06; C07C225/30; C07D217/24 | Oldest priority date: 2010-04-30 | Publication date: 2020-05-19

Score: 11.738287 | Text size: 199526 | Find: similar documents

consists of known bioactive libraries, natural product libraries, and commercial libraries such as ChemDiv, ChemBridge, etc.

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COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING DISEASES AND DISORDERS ASSOCIATED WITH MUTANT KCNJ5

Richard Lifton [US]; Ute Scholl [DE]

Score: 20.795069 | Text size: 190171 | Find: similar documents

70.1 75.5 72.8 YU039827 Microsource 2300165 Amiodarone hydrochloride 77.8 65.9 71.8 YU200116 ChemDiv G281-2440 54.5 87.7 71.1 YU164429 ChemDiv D089-0725 65.8 75.6 70.7 YU182169 ChemDiv D393-0253 63.3 77.5 70.4 YU163288 ChemDiv C620-0363 70.5 68.6 69.5 YU164416 ChemDiv D089-0533 53.7 82.7 68.2 YU214875 ChemDiv L491-0661 84.0 52.1 68.1 YU165270 ChemDiv D297-0001 94.9 40.9 67.9 YU164350 ChemDiv D089-0310 81.9 50.4 66.1 YU039449 NCC SAM001246981 Indatraline 70.6 61.3 65.9 YU171244 ChemDiv 5340-0013 58.6 73.1 65.8 YU155938 ChemDiv 2434-0134 83.4 47.9 65.7 YU195274 ChemDiv F580-1522 74.6 49.9 62.3 YU156667 ChemDiv 3534-0434 68.1 56.0 62.0 YU164338 ChemDiv D089-0264 54.7 69.0 61.9 YU164351 ChemDiv D089-0311 77.7 44.0 60.8 YU164423 ChemDiv D089-0559 66.6 54.9 60.8 YU200600 ChemDiv G345-0648 84.

CFTR REGULATORS AND METHODS OF USE THEREOF

Alan S. VERKMAN [US]; Marc H. LEVIN [US]; Onur Cil [US]

Score: 15.926296 | Text size: 420283 | Find: similar documents

1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATING CANCER

BASTIAN, Jolie Anne [US]; CHEN, Jiehao [US]; COHEN, Jeffrey Daniel [US]; HENRY, James Robert [US]; MCMILLEN, William Thomas [US]; REAMAN, Bradley Earl [US]; RUBIO, Almudena [US]; SALL, Daniel Jon [US]; ZHAO, Gaiying [US]

Score: 12.59831 | Text size: 133158 | Find: similar documents

of unlabeled 1-(2,4-difluorophenyl)-3-{[1-(phenylcarbonyl)-2,3-dihydro-1H-indol-5-yl]methyl}urea (ChemDiv, Cat# G714-0242) )100 μM to 50 nM

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COMPOSITIONS AND METHODS FOR SUPPRESSING AND/OR TREATING A GROWTH RELATED DISEASE AND/OR A CLINICAL CONDITION THEREOF

CHOI, Kang-Yell [KR]; CHOI, Sehee [KR]; SEO, Seol Hwa [KR]; KIM, Eunhwan [KR]

Score: 15.755042 | Text size: 118797 | Find: similar documents

that inhibited the CXXC5–DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described ... delay growth plate senescence, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5–DVL interaction

COMPOSITIONS AND METHODS FOR ACTIVATING NRF2-DEPENDENT GENE EXPRESSION

MOELLERING, Raymond [US]; COUKOS, John [US]; LEE, Gihoon [US]; CHANG, Jae Won [US]; MUTLU, Gokhan [US]

Score: 15.518069 | Text size: 138489 | Find: similar documents

CBR-470-0 and CBR-581-9 were from ChemDiv. CBR-470- 1 (initially from ChemDiv as D470-2172) and related analogs were synthesized in house according to full methods described in

COMPOSITIONS AND METHODS FOR SUPPRESSING AND/OR TREATING METABOLIC DISEASES AND/OR A CLINICAL CONDITION THEREOF

CHOI, Kang-Yell [KR]; SEO, Seol Hwa [KR]; KIM, Eunhwan [KR]

Score: 15.628418 | Text size: 228572 | Find: similar documents

that inhibited the CXXC5-DVL interaction, chemical libraries (2,280 compounds: 1,000 from ChemDiv and 1,280 from SigmaLOPAC) were screened by in vitro binding assay that was previously described. ... Library size single compounds at 10 mM in DMSO Library composition Small molecules Source ChemDiv and Sigma LOP AC 1280 Screen Format 96-well black polystyrene plates Coneentration(s) tested ... of the CXXC5-DVL interface, 2,280 compounds were screened from chemical libraries (1,000 from ChemDiv and 1,280 from SigmaLOPAC) with an in vitro assay system that monitors the CXXC5-DVL interaction

RNF41 as a biomarker predicting response to lenalidomide in non-del(5q) MDS

Alan List [US]

Publication date: 2020-04-07 | Patent publication No.: US-10612097-B2 | Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc. [US] | IPC: C12Q1/68; G01N33/574; C12Q1/6883; G01N33/573; A61K45/06; A61K31/454 | Oldest priority date: 2012-12-05 | Publication date: 2020-04-07

Score: 14.656486 | Text size: 45103 | Find: similar documents

Corporation (16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, Calif.

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Human pluripotent stem cell derived endocardial endothelium

Charles E. Murry [US]; Lil Pabon [US]; Nathan Palpant [US]

Score: 10.759004 | Text size: 222748 | Find: similar documents

for example, from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM, among others.

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CFTR regulators and methods of use thereof

Alan S. Verkman [US]; Marc H. Levin [US]; Onur Cil [US]; Sujin Lee [US]

Publication date: 2020-03-31 | Patent publication No.: US-10604492-B2 | Assignees: THE REGENTS OF THE UNIVERSTIY OF CALIFORNIA [US] | IPC: C07D251/52; C07D251/46; C07D403/04; A61K45/06; A61K31/53; A61K31/5377; A61K31/496; A61P27/04; A61P1/10; A61K31/55; C07D413/12 | Oldest priority date: 2015-12-24 | Publication date: 2020-03-31

Score: 15.221389 | Text size: 548871 | Find: similar documents

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MYC G-quadruplex stabilizing small molecules and their use

John Schneekloth, Jr. [US]; John Simmons [US]; Kenneth Felsenstein [US]; Beverly Mock [US]; Lindsey Saunders [US]; David Calabrese [US]; Elena Leon [US]

Publication date: 2020-03-31 | Patent publication No.: US-10604499-B2 | Assignees: The United States of America as represented by the Secretary, Department of Health and Human Service [US] | IPC: C07D307/84; A61K31/343; A61P35/00; A61K31/397; A61K31/4025; A61K31/439; A61K31/4525; A61K31/496; A61K31/5377; A61K31/55; A61K45/06; C07D405/06; C07D471/08 | Oldest priority date: 2015-01-05 | Publication date: 2020-03-31

Score: 17.89937 | Text size: 191734 | Find: similar documents

20,000 unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridge and ChemDiv screening libraries, in addition to dyes and controls, were printed in duplicate onto four slides ... Catalog No.Peggy (% c-Myc expression compared to untreated IC50 1 [[image:EMI-C00029]] Commercial: ChemDiv No. D089-563 50% (at 10 μM) 7.6 μM 2 [[image:EMI-C00030]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95% viability (at 10 μM) 3 [[image:EMI-C00031]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4 [[image:EMI-C00032]] Commercial: ChemDiv No. ... No. 6238398 69% (at 10 μM) 89% viability (at 10 μM) 12 [[image:EMI-C00040]] Commercial: ChemDiv No. D089-0350 43% (at 10 μM) 3.4 μM 13 [[image:EMI-C00041]] Commercial: Otava Chemical No.

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GENERATION OF LUNG BUD ORGANOIDS WITH BRANCHING STRUCTURES AND USES THEREOF FOR LUNG DISEASE MODELING

Hans-Willem SNOECK [US]; Ya-Wen CHEN [US]

Score: 12.913692 | Text size: 154155 | Find: similar documents

(A division of Key Organics Limited), Camelford, UK; ChemBridge Corporation, San Diego, Calif.; ChemDiv Inc, San Diego, Calif.; ChemRx Advanced Technologies, South San Francisco, Calif.; ComGenex Inc.

BRAIN OSTEOCALCIN RECEPTOR AND COGNITIVE DISORDERS

Gerard KARSENTY [US]; Arnaud OBRI [US]; Lori KHRIMIAN [US]

Score: 10.759004 | Text size: 254322 | Find: similar documents

COMPOSITIONS AND METHODS FOR TREATING DISEASES ASSOCIATED WITH UNCONTROLLED INFLAMMATORY RESPONSES

BARBOUR, Jason [US]; OTT, David [US]

Score: 13.245268 | Text size: 93189 | Find: similar documents

Each compound is identified by its ChemDiv catalog number. Values in Table 1 are reported as degree of change from the control state.

COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATIC SYSTEM DISORDERS

Hakon Hakonarson [US]; Dong Li [US]; Lifeng Tian [US]; Kenny Nguyen [US]; Patrick Sleiman [US]

Publication date: 2020-02-20 | Patent publication No.: US-20200056238-A1 | Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6883; A61K31/4184; A61K31/4427; A61K31/4709; A61K31/501; A61K31/436; A61K31/519; A61K31/5377; A61P43/00 | Oldest priority date: 2016-08-31 | Publication date: 2020-02-20

Score: 12.011612 | Text size: 151277 | Find: similar documents

Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego, Calif.), ChemDiv, (San Diego, Calif.

SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)

Alan F. List [US]; Sheng Wei [US]

Publication date: 2020-02-20 | Patent publication No.: US-20200055916-A1 | Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: C07K14/705; G01N33/68; A61K47/69; C07K19/00; A61K38/17 | Oldest priority date: 2013-07-05 | Publication date: 2020-02-20

Score: 11.477125 | Text size: 161706 | Find: similar documents

Corporation (16981 Via Taxon, Suite G, San Diego, Calif., 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, Calif.

COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN AND OTHER DISEASES

WU, Jay Jie-Qiang [US]

Publication date: 2020-02-19 | Patent publication No.: EP-3135672-B1 | Assignees: VM Discovery, Inc. [US] | IPC: C07D401/14; C07D401/02; C07D279/14; C07D241/40; C07D487/04; C07D265/36; C07D498/04; A61K31/4162; A61P35/00 | Oldest priority date: 2008-10-10 | Publication date: 2020-02-19

Score: 11.738287 | Text size: 207682 | Find: similar documents

Mo.), Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (San Diego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands), Timtec (Newark, DE) or can be synthesized.

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SMALL MOLECULE-INHIBITORS OF 6-PHOSPHOFRUCTO-1-KINASE FOR REDUCING LACTATE GENERATION BY CANCER CELLS

LEGISA, Matic [SI]; LESNIK, Samo [SI]; KONC, Janez [SI]; SOLMAJER, Tomaz [SI]; VODOPIVEC, Tina [SI]; CAMERNIK, Katja [SI]; K POTOKAR, Urska [SI]; KAVCIC, Luka [SI]

Score: 14.153812 | Text size: 66099 | Find: similar documents

and 18 potential PFK-P inhibitors were purchased from Enamine (1 -8), Chembridge (9-16) and ChemDiv (17 and 18) for in-depth testing (1 st generation of Inhibitors).

NON-POLYAMINE BASED POLYAMINE TRANSPORT INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS

PHANSTIEL IV, Otto [US]; MOOTS, Holly [US]; MALONEY, Patrick [US]; HERSHBERGER, Paul [US]; PEDDIBHOTLA, Satyamaheshwar [US]

Publication date: 2020-02-13 | Patent publication No.: WO-2020033944-A2 | Assignees: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. [US]; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE [US] | IPC: A61K31/496 | Oldest priority date: 2018-08-10 | Publication date: 2020-02-13

Score: 17.002005 | Text size: 190919 | Find: similar documents

round of SAR was primarily fueled by 38 compounds, which were purchased from commercial vendors (ChemDiv) while a robust synthetic route was under development. ... In terms of toxicity profiles, compounds ChemDiv F687-0882 and ChemDiv F687-0884 and compounds 50 and 64 gave IC50 values >38 mM and were deemed relatively non-toxic.

Flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof

Publication date: 2020-02-11 | Patent publication No.: US-10557845-B2 | Assignees: Firmenich Incorporated [US] | IPC: G01N33/543; C07C233/65; C07C235/54; C07C275/30; C07C275/34; C07D307/84; C07D317/68; G01N33/566; G01N33/74; G01N33/50; A23L2/56; A61K8/49; A61K8/55; A61K47/22; A61K47/24; C07D405/12; C07F9/655; A23L27/00; A23L27/20; C07D263/56; C07D213/81; C07D213/85; C07D215/48; C07D217/06; C07D231/14; C07D333/24; C07D333/38; C07D401/04; C07D409/12; C07D417/12; C07D261/18; C07D271/12; C07D275/03; C07D209/08; C07D277/64; C07D209/42; C07D285/135; C07D213/40; C07D307/52; C07D307/68; C07D307/79; C07D307/82 | Oldest priority date: 2003-08-06 | Publication date: 2020-02-11

Score: 9.562369 | Text size: 375177 | Find: similar documents

offices, and other well know suppliers such as Fisher Scientific, TCI America of Philadelphia Pa., ChemDiv of San Diego Calif., Chembridge of San Diego Calif.

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COMPOSITIONS AND METHODS FOR TARGETING A VIRAL INFECTION

CHEN, Bing [US]; FREY, Gary [US]; XIAO, Tianshu [US]

Score: 13.489152 | Text size: 307779 | Find: similar documents

Asinex 1 (Winston-Salem, NC), Bionet (Ryan Scientific, Mount Pleasant, SC), CEREP (Redmond, WA), ChemDiv (San Diego, CA), and ChemBridge (San Diego, CA), ENAMINE (Ukraine), Life Chemicals (Burlington, ON, ... Asinex 1 (Winston-Salem, NC), Bionet (Ryan Scientific, Mount Pleasant, SC), CEREP (Redmond, WA), ChemDiv (San Diego, CA), and ChemBridge (San Diego, CA), ENAMINE (Ukraine), Life Chemicals (Burlington, ON,

USE OF TOLL-LIKE RECEPTOR 2 (TLR-2) AGONIST FOR MODULATING HUMAN IMMUNE RESPONSE

DOWLING, David, J. [US]; LEVY, Ofer [US]; BORRIELLO, Francesco [US]; SCOTT, David, A. [US]; BRIGHTMAN, Spencer, E. [US]

Publication date: 2020-01-30 | Patent publication No.: WO-2020023872-A1 | Assignees: CHILDREN'S MEDICAL CENTER CORPORATION [US]; DANA-FARBER CANCER INSTITUTE, INC. [US] | IPC: A01N43/04; A61K31/70 | Oldest priority date: 2018-07-27 | Publication date: 2020-01-30

Score: 12.211837 | Text size: 387085 | Find: similar documents

Methods for producing enteroendocrine cells that make and secrete insulin

Chutima Talchai [US]; Domenico Accili [US]

Publication date: 2020-01-28 | Patent publication No.: US-10544415-B2 | Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: C12N15/113; G01N33/50; A61K31/7088; A61K39/395; C12N5/071 | Oldest priority date: 2010-05-12 | Publication date: 2020-01-28

Score: 11.477125 | Text size: 206394 | Find: similar documents

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MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE

SCHNEEKLOTH, John, Jr. [US]; SIMMONS, John [US]; FELSENSTEIN, Kenneth [US]; MOCK, Beverly [US]; SAUNDERS, Lindsey [US]; GAREISS, Peter [US]; CALABRESE, David [US]; LEON, Elena [US]

Publication date: 2020-01-22 | Patent publication No.: EP-3597186-A1 | Assignees: The U.S.A. as represented by the Secretary, Department of Health and Human Services [US]; Yale University, Inc. [US] | IPC: A61K31/343; A61P35/00; C07D307/84 | Oldest priority date: 2015-01-05 | Publication date: 2020-01-22

Score: 18.024454 | Text size: 182184 | Find: similar documents

20,000 unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridge and ChemDiv screening libraries, in addition to dyes and controls, were printed in duplicate onto four slides ... No.Peggy (% c-Myc expression compared to untreated)IC50 1 [[image:ib0038]] Commercial: ChemDiv No. D089-0563 50% (at 10 μM) 7.6 μM 2 [[image:ib0039]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95% viability (at 10 μM) 3 [[image:ib0040]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4 [[image:ib0041]] Commercial: ChemDiv No. D089-0559 73% (at 10 μM) 75% viability (at 10 μM) 5 [[image:ib0042]] Commercial: ChemBridge No.

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Methods of treating muscular dystrophy

Dean Burkin [US]; Ryan Wuebbles [US]

Publication date: 2020-01-21 | Patent publication No.: US-10537553-B2 | Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/404; A61K45/06 | Oldest priority date: 2013-03-15 | Publication date: 2020-01-21

Score: 10.328181 | Text size: 367834 | Find: similar documents

et al., 2006). 2) DIVERSet library (Chembridge Corp., San Diego, Calif.) and compounds from the ChemDiv library. 3) LOPAC library (Sigma-RPI) consists of 1280 pharmaceutically active compounds.

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Oxadiazole derivative and pharmaceutical containing same

Katsuhiko Yanagisawa [JP]; Akiyoshi Kawai [JP]

Publication date: 2020-01-21 | Patent publication No.: US-10538516-B2 | Assignees: National Center for Geriatrics and Gerontology [JP] | IPC: C07D413/04; C07D413/14; C07D413/12; C07D413/06; C07D285/08; C07D285/12; C07D271/06; C07D271/10; A61K31/4196; A61K31/4709; A61K31/5377; A61K31/41; A61K31/4245; A61K31/4178 | Oldest priority date: 2015-03-25 | Publication date: 2020-01-21

Score: 11.227331 | Text size: 311357 | Find: similar documents

UORSY Ltd., Vitas-M Laboratory Ltd., Interbioscreen Ltd., Interchim Inc., Ryan Scientific Inc., ChemDiv Inc., through Namiki Shoji Co., Ltd. or Kishida Chemical Co., Ltd., when purchased in Japan.

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SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INHIBITORS

Alan S. Verkman [US]; Cristina Esteva-Font [US]

Score: 15.518069 | Text size: 143763 | Find: similar documents

Identification of Stabilizers of Multimeric Proteins

Isabella A. Graef [US]; Mamoun M. Alhamadsheh [US]

Publication date: 2020-01-16 | Patent publication No.: US-20200016098-A1 | Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/12; A61K31/4196; A61K31/428; A61K31/433; C07D231/12; C07D487/04; A61K31/519; A61K31/166 | Oldest priority date: 2010-05-07 | Publication date: 2020-01-16

Score: 12.011612 | Text size: 137828 | Find: similar documents

120,000 compounds from the Stanford IITBC library were screened (Diverse compounds form Chemdiv, Chembridge, SPECS, and LOPAC1280-1280 compounds Library of Pharmacologically Active Compounds from

SWEET FLAVOR MODIFIER

TACHDJIAN, Catherine [US]; KARANEWSKY, Donald [US]; WERNER, Sara [US]; DARMOHUSODO, Vincent [US]; YAMAMOTO, Jeff [US]

Score: 10.759004 | Text size: 249393 | Find: similar documents

other well known chemical suppliers such as Fisher Scientific, TCI America of Philadelphia, PA, ChemDiv of San Diego, CA, Chembridge of San Diego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the

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Proteostasis regulators

Megan Foley [US]; Bradley Tait [US]; Matthew Cullen [US]

Publication date: 2020-01-14 | Patent publication No.: US-10532996-B2 | Assignees: Proteostasis Therapeutics, Inc. [US] | IPC: C07D403/06; C07D405/06; C07D401/06; C07D249/06; C07D207/333; C07D207/337; C07D231/12; C07D263/32; C07D275/02; C07D295/185; C07D333/20; C07D471/04; C07D333/22 | Oldest priority date: 2011-05-12 | Publication date: 2020-01-14

Score: 12.011612 | Text size: 219476 | Find: similar documents

Compound A47 (also shown below) was purchased from ChemDiv, San Diego, Calif.

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METHOD TO DETECT ACTIVITY OF A POLYMERASE

BERGBREDE, Tim [DE]; LARSSON, Nils-Göran [DE]; GUSTAFSSON, Claes [SE]; FALKENBERG-GUSTAFSSON, Maria [SE]

Publication date: 2020-01-08 | Patent publication No.: EP-3303613-B1 | Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. [DE]; Lead Discovery Center GmbH [DE] | IPC: C12Q1/68 | Oldest priority date: 2015-05-29 | Publication date: 2020-01-08

Score: 12.913692 | Text size: 122895 | Find: similar documents

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SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)

LIST, Alan F. [US]; WEI, Sheng [US]

Score: 11.477125 | Text size: 173774 | Find: similar documents

ChemBridge Corporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA, www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego, CA 92121, USA); Life Chemicals (1103 Orange Center Road,

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Anti-oral Squamous Cell Carcinoma Effects of a Potent TAZ Inhibitor AR-42

Lingyu Su; Si Wang; Ting Yuan; Xudong Xie; Xiaoming Fu; Ping Ji; Lei Zhong; Wenzhao Liu

PMC ID: PMC6930442 | DOI: 10.7150/jca.32436 |Journal: Journal of Cancer, 11(1) pp. 364-373 | Publisher: IvyspringInternational Publisher |Publication date: 2020-01-01

Originaldocument: PMC | Score: 16.650314 | Text size: 33910 | Find: similardocuments

In brief, HEK293-TAZ cells were seeded in 96-well plates, and treated with small molecules from ChemDiv compound library and an in-house focused library for 24 h at 37 °C. ... reporter assay on HEK293-TAZ cells to screen TAZinhibitor in an in-house focused library and ChemDiv compound library, and found that the HDAC inhibitor AR-42 (Fig.

Identification of Plasmodium dipeptidyl aminopeptidase allostericinhibitors by high throughput screening

Mateo I. Sanchez; Laura E. deVries; Christine Lehmann; Jeong T. Lee; Kenny K. Ang; Christopher Wilson; Steven Chen; Michelle R.Arkin; Matthew Bogyo; Edgar Deu; Luzia Helena Carvalho

PMC ID: PMC6919601 | DOI: 10.1371/journal.pone.0226270 |Journal: PLoS ONE, 14(1) | Publisher: PublicLibrary of Science | Publication date: 2019-12-18

Original document: PMC | Score: 13.996932 | Text size: 57294 | Find: similardocuments

is composedof 104,121 compounds and was assembled from numerous commercial vendors (ChemBridge,ChemDiv and SPECS), and the Celera Protease Inhibitor Collection of 1,817 compounds, which is unique and

Discovery of Non-peptide Small Molecule Allosteric Modulators of theSrc-family Kinase, Hck

Heather R.Dorman; David Close; Bentley M.Wingert; Carlos J.Camacho; Paul A. Johnston; Thomas E.Smithgall

PMC ID: PMC6893557 | DOI: 10.3389/fchem.2019.00822 |Journal: Frontiers in Chemistry, 7(1) | Publisher: Frontiers Media S.A. |Publication date: 2019-11-28

Originaldocument: PMC | Score: 13.996932 | Text size: 48193 | Find: similardocuments

Screeninglibraries were purchased from ChemDiv (10,000 non-peptidepeptidomimetic library) and ChemBridge (50,000 compound diversity library).

Nanomolar-potency ‘co-potentiator’ therapy for cystic fibrosis caused bya defined subset of minimal function CFTR mutants

Puay-Wah Phuan; Joseph-AnthonyTan;Amber A. Rivera; Lorna Zlock; Dennis W.Nielson;Walter E.Finkbeiner;Peter M. Haggie; Alan S. Verkman

PMC ID: PMC6881293 | DOI: 10.1038/s41598-019-54158-2 |Journal: Scientific Reports, 9(1) | Publisher: NaturePublishing Group UK |Publication date: 2019-11-27

Originaldocument: PMC | Score: 14.2392435 | Text size: 45168 | Find: similar documents

Forscreening, 120,000 diverse drug-like synthetic compounds (ChemDiv Inc.,San Diego, CA) were tested. Other chemicals were purchased from Sigma unlessotherwise stated.

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2inhibitors

Irina Kufareva; Benoit Bestgen; Paul Brear; Renaud Prudent; BéatriceLaudet;VirginieMoucadel;MohamedEttaoussi;Celine F. Sautel; Isabelle Krimm; Matthias Engel; Odile Filhol; Marc Le Borgne; ThierryLomberget;Claude Cochet; Ruben Abagyan

PMC ID: PMC6828666 | DOI: 10.1038/s41598-019-52141-5 |Journal: Scientific Reports, 9(1) | Publisher: NaturePublishing Group UK |Publication date: 2019-11-04

Originaldocument: PMC | Score: 13.536236 | Text size: 82786 | Find: similardocuments

reagent gradeor better and were supplied by the following companies: Chembridge (San Diego,CA), ChemDiv(San Diego, CA), Enamine (Kiev, Ukraine),InterBioScreen (Moscow, Russia), LifeChemicals (Kiev,

Novel Hit Compounds as Putative Antifungals: The Case of Aspergillusfumigatus

Eftichia Kritsi; Minos-TimotheosMatsoukas;ConstantinosPotamitis;Anastasia Detsi; Marija Ivanov; Marina Sokovic; Panagiotis Zoumpoulakis;AthinaGeronikaki;Rino Ragno

PMC ID: PMC6864791 | DOI: 10.3390/molecules24213853 |Journal: Molecules, 24(1) | Publisher: MDPI | Publication date: 2019-10-25

Original document: PMC | Score: 14.363574 | Text size: 49217 | Find: similardocuments

Sample Availability:Samples of the compounds 1–2, 3–5 and 6–8 were purchased from ChemDiv,Mcule and eMolecules, respectively. Supplementary Materials The following areavailable online.

A Chemosensory GPCR as a Potential Target to Control the Root-KnotNematode Meloidogyne incognita Parasitism in Plants

Emmanuel Bresso; Diana Fernandez; Deisy X. Amora; Philippe Noel; Anne-SophiePetitot;Maria-EugêniaLisei de Sa;Erika V. S.Albuquerque;Etienne G. J.Danchin;Bernard Maigret; NatáliaF. Martins

PMC ID: PMC6832152 | DOI: 10.3390/molecules24203798 |Journal: Molecules, 24(1) | Publisher: MDPI | Publication date: 2019-10-22

Originaldocument: PMC | Score: 17.646307 | Text size: 62242 | Find: similardocuments

selectedmolecules allowed the identification of an active compound, namely C260-2124,from the ChemDivprovider, which can serve as a starting point forfurther investigations. ... From this list, it appeared that 85 compounds camefrom the ChemDiv provider’s library. ... the GPCR-centredlibraries encompassing six compounds providers: Asinex [73], Chembridge[74], ChemDiv [75], LifeChemicals [76], Otava [77] andSelleckchem [78], representing 112,951 molecules.

Design and Selection of Novel C1s Inhibitors by In Silico and In VitroApproaches

KatalinSzilágyi; IstvánHajdú; BeátaFlachner;ZsoltLőrincz; JúliaBalczer;PéterGál;PéterZávodszky; Chiara Pirli; BalázsBalogh;István M.Mándity;SándorCseh;GyörgyDormán

PMC ID: PMC6832932 | DOI: 10.3390/molecules24203641 |Journal: Molecules, 24(1) | Publisher: MDPI | Publication date: 2019-10-09

Originaldocument: PMC | Score: 16.44229 | Text size: 76556 | Find: similardocuments

removal ofthe duplicated structures resulted in 445,457 compounds (Enamine (71,311compounds), ChemDiv(258,797 compounds), Chembridge (60,052 compounds),Interbioscreen (31,255 compounds) and Life ... from the actual edition of thetop vendor databases (~5 million compounds): Asinex, ChemBridge, ChemDiv,Enamine, Interbioscreen, Life Chemicals, Specs, UkrOrg, etc.[21,22,23,24,25,26,27,28].

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic OcularNeovascularization

Paulina M.Wojnarowicz;Raquel Lima eSilva;Masayuki Ohnaka; Sang Bae Lee; Yvette Chin; Anita Kulukian; Sung-Hee Chang; Bina Desai; Marta GarciaEscolano;Riddhi Shah; Marta Garcia-Cao; Sijia Xu; Rashmi Kadam; Yehuda Goldgur; Meredith A.Miller;OuathekOuerfelli;Guangli Yang;Tsutomu Arakawa; Steven K.Albanese;William A.Garland;Glenn Stoller; JaideepChaudhary;Larry Norton; Rajesh KumarSoni;John Philip; Ronald C.Hendrickson;Antonio Iavarone; Andrew J.Dannenberg;John D. Chodera; Nikola Pavletich; Anna Lasorella; Peter A.Campochiaro;Robert Benezra

PMC ID: PMC6896334 | DOI: 10.1016/j.celrep.2019.08.073 |Journal: Cell reports, 29(1) pp. 62-75.e7 |Publicationdate: 2019-10-01 | Print publication date: 2019-10-01

Originaldocument: PMC | Score: 13.104898 | Text size: 96574 | Find: similardocuments

Compiledlists of commercially available compounds (libraries available fromChemBridge, ChemDiv, Maybridge, and Salor) were screened using abeta release of Autodock 4.0 (The Scripps Research

Identification of Fatty Acid Binding Protein 5 Inhibitors Through Similarity-BasedScreening

Yuchen Zhou; Matthew W. Elmes; Joseph M.Sweeney;Olivia M. Joseph; Joyce Che; Hao-Chi Hsu; Huilin Li; Dale G. Deutsch; Iwao Ojima; Martin Kaczocha; Robert C. Rizzo

Originaldocument: PMC | Score: 14.2392435 | Text size: 67063 | Find: similardocuments

in thebinding site from different rank-ordered lists, 78 compounds were ultimatelypurchased (ChemDivvendor) for experimental testing.

Predictive Power of In Silico Approach to Evaluate Chemicals against M.tuberculosis: A Systematic Review

Giulia OliveiraTimo;Rodrigo SouzaSilva Valle dos Reis; AdrianaFrançozo de Melo; Thales VianaLabourdette Costa; Pérola deOliveira Magalhães;MauricioHomem-de-Mello

PMC ID: PMC6789803 | DOI: 10.3390/ph12030135 |Journal: Pharmaceuticals, 12(1) | Publisher: MDPI | Publication date: 2019-09-16

Original document: PMC | Score: 14.490094 | Text size: 58450 | Find: similardocuments

CollaborativeDrug Discovery Database [49,50]; Other (CDRI [60], FDA approved drugs[67], ChemDiv [6], ChemSpider [59], TAACF [16], GSK [16],Enamine REAL [61], NCI [21] and Specs [70]).

Leishmania mexicana Trypanothione Reductase Inhibitors: Computational andBiological Studies

Félix Matadamas-Martínez; AliciaHernández-Campos; AlfredoTéllez-Valencia; AlejandraVázquez-Raygoza; SandraComparán-Alarcón; LiliánYépez-Mulia; Rafael Castillo

PMC ID: PMC6767256 | DOI: 10.3390/molecules24183216 |Journal: Molecules, 24(1) | Publisher: MDPI | Publication date: 2019-09-04

Originaldocument: PMC | Score: 14.301138 | Text size: 52177 | Find: similardocuments

GeneralInformation Compounds ZINC04684558 and ZINC09642432 were purchased from ChemDiv (SanDiego, CA, USA), and compounds ZINC12151998, ZINC14970552, and ZINC11841871were purchased

Identification of Novel Antibacterials Using Machine Learning Techniques

Yan A. Ivanenkov; Alex Zhavoronkov; Renat S.Yamidanov;Ilya A. Osterman; Petr V. Sergiev; Vladimir A.Aladinskiy;Anastasia V.Aladinskaya;Victor A.Terentiev;Mark S. Veselov; Andrey A.Ayginin;Victor G.Kartsev;Dmitry A.Skvortsov;Alexey V.Chemeris;Alexey Kh.Baimiev;Alina A.Sofronova;Alexander S.Malyshev;Gleb I. Filkov; Dmitry S.Bezrukov;Bogdan A.Zagribelnyy;Evgeny O. Putin; Maria M.Puchinina;Olga A. Dontsova

PMC ID: PMC6719509 | DOI: 10.3389/fphar.2019.00913 |Journal: Frontiers in Pharmacology, 10(1) | Publisher: Frontiers Media S.A. |Publication date: 2019-08-27

Originaldocument: PMC | Score: 17.583435 | Text size: 67557 | Find: similardocuments

In general,we used two collections of commercially available compounds by ChemDiv andIBS. WhileChemDiv stock mainly contains organic compounds ofsynthetic origin, IBS basically focuses on nature-based ... These moleculeswere randomly selected and purchased from ChemDiv and IBScollections.

High‐ThroughputApproaches in Carbohydrate ‐Active Enzymology: Glycosidase and GlycosylTransferase Inhibitors, Evolution, and Discovery

Lemeng Chao; Seino Jongkees

Originaldocument: PMC | Score: 14.426556 | Text size: 49031 | Find: similardocuments

group,initial hits against O‐GlcNAc transferase from an expanded version of the the commercial ChemDivlibrary21were diversified through combinatorial chemistry based on a conserved

A Ligand-Based Virtual Screening Method Using Direct Quantification ofGeneralization Ability

Weixing Dai; Dianjing Guo

PMC ID: PMC6651094 | DOI: 10.3390/molecules24132414 |Journal: Molecules, 24(1) | Publisher: MDPI | Publication date: 2019-06-30

Originaldocument: PMC | Score: 14.74994 | Text size: 37243 | Find: similardocuments

All the testcompounds were bought from ChemDiv (San Diego, CA, USA).

TRAF6 mediates human DNA2 polyubiquitination and nuclear localization tomaintain nuclear genome integrity

Yuan Meng; Changwei Liu; Lei Shen; Mian Zhou; Wenpeng Liu; Claudia Kowolik; Judith LCampbell;Li Zheng; Binghui Shen

Originaldocument: PMC | Score: 13.76273 | Text size: 62685 | Find: similardocuments

The TRAF6 E3ligase inhibitor C25–140 (ChemDiv, Catalog #G827–0140) was added for 48h at a final concentration of 30 μM.

Development and optimization of a high-throughput screening methodutilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics

Laura Abriola; Denton Hoyer; Conor R. Caffrey; David L.Williams;Timothy P.Yoshino;Jon J. Vermeire; Josué deMoraes

PMC ID: PMC6546214 | DOI: 10.1371/journal.pone.0217019 |Journal: PLoS ONE, 14(1) | Publisher: PublicLibrary of Science | Publicationdate: 2019-06-03

Originaldocument: PMC | Score: 14.618862 | Text size: 29332 | Find: similardocuments

Small MW,ChemBridge DiverSet, Enzo kinase inhibitor, Yale Compounds, MicroSourcePharmakon 1600,ChemDiv Diversity, Rainforest Endophyte Extracts)were screened against A. ceylanicum eggs in our egg hatch

Leveraging heterogeneous data from GHS toxicity annotations, molecularand protein target descriptors and Tox21 assay readouts to predict andrationalise acute toxicity

Chad H. G. Allen; Lewis H. Mervin; Samar Y. Mahmoud; Andreas Bender

PMC ID: PMC6544914 | DOI: 10.1186/s13321-019-0356-5 |Journal: Journal of Cheminformatics, 11(1) | Publisher: SpringerInternational Publishing | Publicationdate: 2019-05-31

Originaldocument: PMC | Score: 16.524874 | Text size: 84316 | Find: similardocuments

with the“reactive, unstable, toxic” endpoint, which includes structural alerts definedby ChemDiv, LifeChemicals and Enamine used for their internalcompound selection purposes, which was also ... propane and cyclopropane 25.13.1 × 10−5 Life chemicals TA567 Thioureas 25.1 3.1 ×10−5 ChemDiv TA885 Life chemicals TA1075 Ontarioinstitute for cancer research TA914 Nitrosos 16.

Subcellular compartmentalization of PKM2 identifies anti-PKM2 therapyresponse in vitro and in vivo mouse model of human non-small-cell lung cancer

Akiko Suzuki; Sachin Puri; Pamela Leland; Ankit Puri; Tarsem Moudgil; Bernard A. Fox; Raj K. Puri; Bharat H. Joshi; Aamir Ahmad

PMC ID: PMC6532891 | DOI: 10.1371/journal.pone.0217131 |Journal: PLoS ONE, 14(1) | Publisher: PublicLibrary of Science | Publicationdate: 2019-05-23

Originaldocument: PMC | Score: 13.878843 | Text size: 55081 | Find: similardocuments

(SMI-Compound2825–0090, N-(3-carboxy-4-hydroxy) phenyl 1–2,5,-dimethylpyrole) was purchasedfromChemDiv (San Diego, CA) and dissolved in PBS for treating theNSCLC and normal lung cell lines.

Novel chemical starting points for drug discovery in leishmaniasis andChagas disease

Irene Roquero; Juan Cantizani; Ignacio Cotillo; M. Pilar Manzano; Albane Kessler; J. JulioMartín; Case W. McNamara

PMC ID: PMC6545338 | DOI: 10.1016/j.ijpddr.2019.05.002 |Journal: International Journal for Parasitology: Drugs and DrugResistance, 10(1) pp. 58-68 | Publisher: Elsevier | Publication date: 2019-05-22

Originaldocument: PMC | Score: 13.76273 | Text size: 72868 | Find: similardocuments

the screencompounds. 76 T. cruzi hits and 63 L. donovani hits were available for resupplyfrom ChemDiv and Life Chemicals.

Advancement of the5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarmthe Bacterial SOS Response

Trevor Selwood; Brian J. Larsen; Charlie Y. Mo; Matthew J.Culyba;Zachary M.Hostetler;Rahul M. Kohli; Allen B. Reitz; Simon D. P. Baugh

PMC ID: PMC6305444 | DOI: 10.3389/fmicb.2018.02961 |Journal: Frontiers in Microbiology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-12-18

Originaldocument: PMC | Score: 14.2392435 | Text size: 51939 | Find: similardocuments

Analogswhich were not synthesized were obtained from commercial vendors ChemDiv (SanDiego, CA, United States) and Vitas-M Laboratory (Champagne, IL).

Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoicacid/HIF-1α/VEGF signalling in MCF-7 breastcancer cells

Valerio Ciccone; Erika Terzuoli; Sandra Donnini; AntonioGiachetti;Lucia Morbidelli; Marina Ziche

Originaldocument: PMC | Score: 13.536236 | Text size: 64085 | Find: similardocuments

MethodsChemicals and reagents The ALDH1A1 selective inhibitor CM037 was from ChemDivInc. (San Diego, CA, USA).

Inhibition of CPAP–tubulin interaction prevents proliferation ofcentrosome‐amplified cancercells

AruljothiMariappan;Komal Soni; Kenji Schorpp; Fan Zhao; Amin Minakar; Xiangdong Zheng; Sunit Mandad; Iris Macheleidt; Anand Ramani; TomášKubelka;MaciejDawidowski;KristinaGolfmann;Arpit Wason; Chunhua Yang; Judith Simons; Hans‐Günther Schmalz; Anthony A Hyman; Ritu Aneja;Roland Ullrich; Henning Urlaub; MargareteOdenthal;ReinhardtBüttner; Haitao Li; Michael Sattler; Kamyar Hadian; JayGopalakrishnan

Originaldocument: PMC | Score: 12.700202 | Text size: 117793 | Find: similardocuments

in the CPAP‐tubulin HTScampaign was composed of compounds acquired from three providers, namelyChemDiv,Inc. (10,000 compounds), Enamine, Ltd. (10,000 compounds), andChemBridge, Corp. (5,000 compounds).

An Experimental Pipeline for Initial Characterization of Bacterial TypeIII Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia

Jessica M.Morgan;Hanh N. Lam; Jocelyn Delgado; Justin Luu; Sina Mohammadi; Ralph R. Isberg; Helen Wang; VictoriaAuerbuch

PMC ID: PMC6262202 | DOI: 10.3389/fcimb.2018.00404 |Journal: Frontiers in Cellular and Infection Microbiology, 8(1) | Publisher: FrontiersMedia S.A. | Publicationdate: 2018-11-22

Originaldocument: PMC | Score: 13.996932 | Text size: 65275 | Find: similardocuments

INP0010(CAS# 68639-26-9) was obtained from ChemDiv.

QSAR-Based Virtual Screening: Advances and Applications in Drug Discovery

Bruno J. Neves; Rodolpho C.Braga;Cleber C.Melo-Filho;JoséTeófilo Moreira-Filho; Eugene N.Muratov;Carolina HortaAndrade

PMC ID: PMC6262347 | DOI: 10.3389/fphar.2018.01275 |Journal: Frontiers in Pharmacology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-11-13

Originaldocument: PMC | Score: 14.74994 | Text size: 33091 | Find: similardocuments

data wereused to develop QSAR models and, then, applied to screen near 700,000 compoundsfromChemDiv database.

Discovery of a Novel Microtubule Targeting Agent as an Adjuvant forCancer Immunotherapy

Fumi Sato-Kaneko; Xiaodong Wang; Shiyin Yao; Tadashi Hosoya; Fitzgerald S.Lao;Karen Messer; Minya Pu; Nikunj M. Shukla; Howard B. Cottam;Michael Chan; Dennis A. Carson; Maripat Corr; Tomoko Hayashi

Originaldocument: PMC | Score: 13.996932 | Text size: 52535 | Find: similardocuments

Othercompounds were purchased from ChemBridge Corporation and ChemDiv andwere verified for purity (>98%) by LC-MS.

Correcting glucose-6-phosphate dehydrogenase deficiency with asmall-molecule activator

Sunhee Hwang; Karen Mruk; Simin Rahighi; Andrew G. Raub; Che-Hong Chen; Lisa E. Dorn; Naoki Horikoshi; Soichi Wakatsuki; James K. Chen;DariaMochly-Rosen

PMC ID: PMC6168459 | DOI: 10.1038/s41467-018-06447-z |Journal: Nature Communications, 9(1) | Publisher: NaturePublishing Group UK |Publication date: 2018-10-02

Originaldocument: PMC | Score: 13.536236 | Text size: 71259 | Find: similardocuments

All thecompounds purchased from SPECS, Chembridge, ChemDiv Kinase,LOPAC, Microsource Spectrum, Biomol FDA, Biomol ICCB, and NIH ClinicalCollection were

Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STATTargeting Compounds as a Novel Treatment Strategy of CVDs

MartynaPlens-Galaska; MalgorzataSzelag;Aida Collado; Patrice Marques; Susana Vallejo; MariellaRamos-González; Joanna Wesoly; MaríaJesus Sanz;ConcepciónPeiró; Hans A. R.Bluyssen

PMC ID: PMC6156247 | DOI: 10.3389/fimmu.2018.02141 |Journal: Frontiers in Immunology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-09-19

Originaldocument: PMC | Score: 12.700202 | Text size: 108167 | Find: similardocuments

C01 andC01L_A03-C01L_F03 were purchased from Enamine; E01 from Asinex; F01 from ChemDiv;STX-0119 from Merck and STATTIC from Sigma-Aldrich.

Small molecules that target group II introns are potent antifungal agents

Olga Fedorova; G. Erik Jagdmann; Rebecca L. Adams; Lin Yuan; Michael C. VanZandt;Anna Marie Pyle

Originaldocument: PMC | Score: 13.878843 | Text size: 58425 | Find: similardocuments

(76compounds), protease inhibitors (53 compounds) and additional compounds fromChemBridge MW andChemDiv to bring the total number of compounds to 10000.

The Small-Compound Inhibitor K22 Displays Broad Antiviral Activityagainst Different Members of the Family Flaviviridae and Offers Potential as aPanviral Inhibitor

ObdulioGarcía-Nicolás; Philip V'kovski; Nathalie J.Vielle;Nadine Ebert; Roland Züst; Jasmine Portmann; HanspeterStalder;VéroniqueGaschen;GabrielleVieyres;Michael Stoffel; MatthiasSchweizer;ArturSummerfield;Olivier Engler; ThomasPietschmann;Daniel Todt; Marco P. Alves;Volker Thiel; StephaniePfaender

Originaldocument: PMC | Score: 13.648543 | Text size: 65154 | Find: similardocuments

benzamide)was purchased from ChemDiv (catalog number 4295-0370; SanDiego, CA) and DMSO.

The TMEM16A channel mediates the fast polyspermy block in Xenopus laevis

Katherine L.Wozniak;Wesley A. Phelps; Maiwase Tembo; Miler T. Lee; Anne E. Carlson

Originaldocument: PMC | Score: 14.2392435 | Text size: 54256 | Find: similardocuments

and 2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide(Ani9) from ChemDiv.

Discovery and Identification of Pyrazolopyramidine Analogs as NovelPotent Androgen Receptor Antagonists

Lingyan Wang; Tianqing Song; Xin Wang; Jiazhong Li

PMC ID: PMC6121070 | DOI: 10.3389/fphar.2018.00864 |Journal: Frontiers in Pharmacology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-08-28

Originaldocument: PMC | Score: 18.165255 | Text size: 48086 | Find: similardocuments

Then the ARcrystal structure (PDB ID:1T65) and Anti-AR were both used to virtually screenthe ChemDivdatabase by using Glide standard precision (SP) dockingprogram. Glide SP, a semi flexible docking method, performs exhaustive samplingand is the recommended balance between speed and accuracy. ChemDiv isnow the recognized global leader in discovery chemistry with the industry'slargest, most ... regression (MLR) method were employed to in silico evaluatethe bioactivities of the filtered ChemDiv chemicals containedin database 2. The development and validation of QSAR models The linear MLR ...preparation Considering the diversity of the molecular structure, thecommercially available ChemDiv structural library(http://www.chemdiv.

A metabolite-derived protein modification integrates glycolysis withKEAP1-NRF2 signaling

Michael J.Bollong;Gihoon Lee; John S. Coukos; Hwayoung Yun; Claudio Zambaldo; Jae Won Chang; Emily N. Chin; Insha Ahmad; Arnab K.Chatterjee;Luke L. Lairson; Peter G. Schultz; Raymond E.Moellering

Originaldocument: PMC | Score: 15.963614 | Text size: 82825 | Find: similardocuments

CBR-470-0and CBR-581-9 were from ChemDiv. CBR-470-1 (initially from ChemDiv asD470-2172) and related analogs were synthesized in house according to fullmethods described in

K284-6111 prevents the amyloid beta-induced neuroinflammation andimpairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression

Ji Yeon Choi; In Jun Yeo; Ki Cheon Kim; Won Rack Choi; Jae-Kyung Jung; Sang-Bae Han; Jin Tae Hong

PMC ID: PMC6087013 | DOI: 10.1186/s12974-018-1269-3 |Journal: Journal of Neuroinflammation, 15(1) | Publisher: BioMedCentral |Publication date: 2018-08-11

Originaldocument: PMC | Score: 13.878843 | Text size: 52408 | Find: similardocuments

(K284-6111)and other chemicals were obtained from ChemDiv, Inc. (Cat No.3292320, San Diego, CA).

Targeting the Microenvironment in High Grade Serous Ovarian Cancer

Nkechiyere G.Nwani;Livia E. Sima; WilbertoNieves-Neira; Daniela Matei

PMC ID: PMC6115937 | DOI: 10.3390/cancers10080266 |Journal: Cancers, 10(1) | Publisher: MDPI | Publication date: 2018-08-10

Originaldocument: PMC | Score: 13.42576 | Text size: 89735 | Find: similardocuments

efforts usedan AlphaLISA-based assay adapted to high-throughput screening and applied tothe ChemDivlibrary leading to the discovery and validation ofseveral small molecules [126].

Insights into the development of chemical probes for RNA

Brittany SMorgan;Jordan E Forte; Amanda EHargrove

Originaldocument: PMC | Score: 14.2392435 | Text size: 66141 | Find: similardocuments

Recently,chemical companies have designed such focused libraries (ChemDiv,Nucleic Acid Ligands: http://www.chemdiv.

Biaryl sulfonamide motifs up- or down-regulate ion channel activity byactivating voltage sensors

Sara I. Liin; Per-Eric Lund; Johan E. Larsson; Johan Brask; BjörnWallner;Fredrik Elinder

Originaldocument: PMC | Score: 14.2392435 | Text size: 60672 | Find: similardocuments

ConsortiumSweden)*; Natural derivatives (TimTec); NIH Clinical Collection (NIH);Peptidomimetics (ChemDiv Inc.)*; and Tocriscreen Plus (Tocris Bioscience).

Identification of a novel c-Myc inhibitor with antitumor effects onmultiple myeloma cells

Ruosi Yao; Xiaoyang Sun; Yu Xie; Xiaoshen Sun; Yao Yao; Hujun Li; Zhenyu Li; Jian Gao; Kailin Xu

Originaldocument: PMC | Score: 17.709631 | Text size: 28027 | Find: similar documents

It wasidentified from the ChemDiv compound database by moleculardocking-based, high-throughput virtual screening. ... The ChemDiv database,a commercially available small molecule database from TopScience Co. ...Because only 2D-structural information was available, all compounds inthe ChemDiv database were preprocessed by using the dbtranslate module in Sybyl-X2.

Identification of a small molecule inhibitor of Ebola virus genomereplication and transcription using in silico screening

Victoria Easton; Martin McPhillie; IsabelGarcia-Dorival; John N. Barr; Thomas A.Edwards;Richard Foster; Colin Fishwick; Mark Harris

Originaldocument: PMC | Score: 17.646307 | Text size: 42059 | Find: similardocuments

Dry stocksof the original compounds were later purchased from the original supplier (ChemDiv)to confirm initial biological activity. Follow-up compounds were purchased fromChemBridge or ChemDiv and shipped as dry stocks. ...structural derivatives, where particular functional groups had been modified,were purchased (from ChemDiv Inc) and a further eight ChemBridgeanalogues were identified using the programme ROCS (rapid overlay

Screening and analysis of acetyl-cholinesterase (AChE) inhibitors in thecontext of Alzheimer's disease

Mohd. Babu Khan; Bhagath KumarPalaka;Tuleshwori DeviSapam;Naidu Subbarao; Dinakara RaoAmpasala

PMC ID: PMC6166398 | DOI: 10.6026/97320630014414 |Journal: Bioinformation, 14(1) pp. 414-428 | Publisher: BiomedicalInformatics |Publication date: 2018-08

Originaldocument: PMC | Score: 19.113825 | Text size: 36455 | Find: similardocuments

Ligandlibrary preparation A library of 23,731 CNS_BBB compounds was obtained fromthe ChemDiv database (http://www.chemdiv.com/cns-bbblibrary/)[21]. CNS-BBB ChemDiv database compound is a known asantioxidant and anti-inflammatory nature, and the 2D structures in Sdf formatwere downloaded from theChemDiv database, and created a 3D-Phasedatabase from Phase module of the Schrodinger, phase version 3.2. ...Discussion Based on this CNS-BBB, Standard Data Format (SDF) data, provided bythe ChemDiv Data base server, finding the top three ligandinhibitors as M1, M8, and M10 shows a good ... -204.27+/-50.94 -214.40 +/12.67Table 3 ADMET Property profile of the top ten hits of CNS-BBB of ChemDiv databasecompounds Compound Ida Molecular Weight1 SASA2 QPLogS3 QPlog- HERG4 QPlog-BB5 %HOA6

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

VirginiaMurillo-Garzón; IrantzuGorroño-Etxebarria; MalinÅkerfelt; Mikael ChristerPuustinen;Lea Sistonen; Matthias Nees; James Carton;Jonathan Waxman; Robert M. Kypta

PMC ID: PMC5931552 | DOI: 10.1038/s41467-018-04042-w |Journal: Nature Communications, 9(1) | Publisher: NaturePublishing Group UK |Publication date: 2018-05-01

Originaldocument: PMC | Score: 13.104898 | Text size: 82903 | Find: similardocuments

Inhibitor 1(3235-0367) and 2 (2124-0331), which were obtained from ChemDiv Inc. (CA,USA) were used at 10 μM for 24 hin migration assays.

Small molecule KDM4s inhibitors as anti-cancer agents

Hongzhi Lin; Qihang Li; Qi Li; Jie Zhu; Kai Gu; Xueyang Jiang; Qianqian Hu; Feng Feng; Wei Qu; Yao Chen; Haopeng Sun

Originaldocument: PMC | Score: 13.536236 | Text size: 76162 | Find: similardocuments

A moleculardocking-based virtual screening against various chemical libraries includeSpecs and ChemDivwas performed to retrieve two compounds withmodest inhibition rate against KDM4D (> 50% at 10 μM).

High Performance Virtual Screening by Targeting a High-resolution RNADynamic Ensemble

Laura R. Ganser; Janghyun Lee; Atul Rangadurai; Dawn K. Merriman; Megan L. Kelly; Aman D. Kansal; BharathwajSathyamoorthy; Hashim M.Al-Hashimi

Originaldocument: PMC | Score: 14.117049 | Text size: 66856 | Find: similardocuments

Michigan,Ann Arbor. 100,000 molecules were synthetic organic molecules with drug-likeproperties (ChemDiv). The other 3,498 compounds consisted of 2,000bioactive molecules (MicroSource Discovery Systems

In Silico Discovery of a Substituted 6-Methoxy-quinalidine withLeishmanicidal Activity in Leishmania infantum

StrahinjaStevanović; Andrej Perdih; MilanSenćanski; SanjaGlišić; Margarida Duarte; Ana M.Tomás; Filipa V. Sena; Filipe M. Sousa; Manuela M.Pereira;Tom Solmajer; Thomas J.Schmidt

PMC ID: PMC6017605 | DOI: 10.3390/molecules23040772 |Journal: Molecules : A Journal of Synthetic Chemistry andNatural Product Chemistry, 23(1) | Publisher: MDPI | Publication date: 2018-03-27

Originaldocument: PMC | Score: 14.301138 | Text size: 49462 | Find: similardocuments

of 500,000commercially available compounds originating from different vendors (e.g.,VITAS-M, ChemDiv, ChemBridge, etc.

Computer-Aided Drug Design in Epigenetics

Wenchao Lu; Rukang Zhang; Hao Jiang; Huimin Zhang; Cheng Luo

PMC ID: PMC5857607 | DOI: 10.3389/fchem.2018.00057 |Journal: Frontiers in Chemistry, 6(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-03-12

Originaldocument: PMC | Score: 13.42576 | Text size: 116979 | Find: similar documents

LSD1; PRMT5ChEMBL ~1.7 million http://www.ebi.ac.uk/chembldb/index.php GCN5; BRD4 ChemDiv ~1.5million http://www.chemdiv.

Exploring G Protein-Coupled Receptors (GPCRs) Ligand Space viaCheminformatics Approaches: Impact on Rational Drug Design

Shaherin Basith; Minghua Cui; Stephani J. Y.Macalino;Jongmi Park; Nina A. B.Clavio;Soosung Kang; Sun Choi

PMC ID: PMC5854945 | DOI: 10.3389/fphar.2018.00128 |Journal: Frontiers in Pharmacology, 9(1) | Publisher: Frontiers Media S.A. |Publication date: 2018-03-09

Originaldocument: PMC | Score: 16.120045 | Text size: 112002 | Find: similardocuments

Kruse etal., 2013 Ki=1.2 uM A, nonrhodopsin (lipid-like) CB2R Enamine, Otava,ChemBridge, ChemDiv, Vitasm, IBS, LifeChemicals, Specs, and TimTec:5,613,820 compounds 13 hits ≥ 50% inhibition at 10 ... 80,700https://www.keyorganics.net ChemBridge 1,100,000 Yhttp://www.chembridge.com ChemDiv 1,500,000 Yhttp://www.chemdiv.com CoCoCo 6,981,500 http://cococo.isof.cnr.

Virtual Screening of Small Molecular Inhibitors against DprE1

Gang Zhang; Song Guo; Huaqing Cui; Jianguo Qi

PMC ID: PMC6017230 | DOI: 10.3390/molecules23030524 |Journal: Molecules : A Journal of Synthetic Chemistry andNatural Product Chemistry, 23(1) | Publisher: MDPI | Publication date: 2018-02-27

Originaldocument: PMC | Score: 18.638195 | Text size: 23102 | Find: similardocuments

Weidentified potential DprE1 inhibitors from the ChemDiv datasetthrough virtual screening based on pharmacophore and molecular docking. ...Results and Discussion The ChemDiv is the industry’s largest,most diverse, and most pharmacologically-relevant commercial collection, ...Preparation for Virtual Screening TheChemDiv dataset containing1.96 million compounds was downloaded from the ZINC database [11]. ... FirstRound of Screening Based on Oprea’s Lead-Likeness Criteria The ChemDiv dataset,containing 1,962,494 compounds, was filtered to exclude compounds that did notfollow ... We identified DprE1 inhibitors from theChemDiv datasetthrough virtual screening based on pharmacophore and molecular docking.

Combination of Virtual Screening Protocol by in Silico toward theDiscovery of Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

Ying Fu; Yi-Na Sun; Ke-Han Yi; Ming-Qiang Li; Hai-Feng Cao; Jia-Zhong Li; Fei Ye

PMC ID: PMC5807903 | DOI: 10.3389/fchem.2018.00014 |Journal: Frontiers in Chemistry, 6(1) | Publisher: FrontiersMedia S.A. |Publication date: 2018-02-06

Originaldocument: PMC | Score: 18.863625 | Text size: 48724 | Find: similardocuments

pharmacophoremodel was used as a 3D query for searching four databases (Maybridge,Chembridge,ChemDiv, and Specs) to discern novel HPPD inhibitors and alsoutilized as a predictive program to estimate ... Subsequently, Chembridge,Maybridge, ChemDiv and Specs were selected as “Input Database”and Hypo1 was imported to “Input Pharmacophore” to ... as a 3D query tool toscreen the chemical databases like Maybridge (20565), Chembridge (40637), ChemDiv (12620),and Specs (37738). ... As a result, 643, 392, 416, and 466 (a total of 1917)compounds from Maybridge, Chembridge, ChemDiv and Specs, weremapped upon all the features of Hypo1.

QStatin, a Selective Inhibitor of Quorum Sensing in Vibrio Species

Byoung Sik Kim; Song Yee Jang; Ye-ji Bang; Jungwon Hwang; Youngwon Koo; Kyung Ku Jang; Dongyeol Lim; Myung Hee Kim; Sang Ho Choi; E. PeterGreenberg

PMC ID: PMC5790914 | DOI: 10.1128/mBio.02262-17 |Journal: mBio, 9(1) | Publisher: AmericanSociety for Microbiology | Publicationdate: 2018-01-30

Originaldocument: PMC | Score: 13.996932 | Text size: 72030 | Find: similardocuments

Hitmolecules were either purchased from ChemDiv (San Diego, CA)or synthesized as described below.

Identification of allosteric inhibitors of the ecto-5'-nucleotidase(CD73) targeting the dimer interface

Rahila Rahimova; Simon Fontanel; Corinne Lionne; Lars PeterJordheim;SuzannePeyrottes;Laurent Chaloin; AvnerSchlessinger

Originaldocument: PMC | Score: 13.76273 | Text size: 68647 | Find: similardocuments

was composedof unique molecules, commercially available from several main suppliers(Asinex, ChemDiv Inc., Vitas-M laboratory and Enamine).

NMR-Fragment Based Virtual Screening: A Brief Overview

Meenakshi Singh; Benjamin Tam; Barak Akabayov

PMC ID: PMC6017141 | DOI: 10.3390/molecules23020233 |Journal: Molecules : A Journal of Synthetic Chemistry andNatural Product Chemistry, 23(1) | Publisher: MDPI | Publication date: 2018-01-25

Originaldocument: PMC | Score: 13.996932 | Text size: 94229 | Find: similardocuments

1500Modified Ro3 compliant Kinase focused fragment library 500 19F labeled fragmentlibrary 500 ChemDiv3D designed fragment library >4000 Ro3compliant Enamine “Simple” fragment library 126,597 Ro3

Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells

Brent D. G. Page; Nicholas C. K.Valerie;Roni H. G.Wright;Olov Wallner; Rebecka Isaksson; Megan Carter; Sean G. Rudd; Olga Loseva; Ann-Sofie Jemth; IngridAlmlöf;Jofre Font-Mateu; SabinLlona-Minguez; PawelBaranczewski; Fredrik Jeppsson; Evert Homan; Helena Almqvist; Hanna Axelsson; Shruti Regmi; Anna-LenaGustavsson;ThomasLundbäck; Martin Scobie; KiaStrömberg; PålStenmark;Miguel Beato; Thomas Helleday

PMC ID: PMC5772648 | DOI: 10.1038/s41467-017-02293-7 |Journal: Nature Communications, 9(1) | Publisher: NaturePublishing Group UK |Publication date: 2018-01-17

Originaldocument: PMC | Score: 13.317075 | Text size: 78980 | Find: similardocuments

(CBCS)primary screening set and several commercial libraries from Enamine, TimTec,Maybridge andChemDiv.

Identification of Collateral Sensitivity to Dihydroorotate DehydrogenaseInhibitors in Plasmodium falciparum

Leila Saxby Ross; MariaJosé Lafuente-Monasterio; TomoyoSakata-Kato;Rebecca E. K.Mandt;Francisco JavierGamo;Dyann F. Wirth; Amanda K. Lukens

Originaldocument: PMC | Score: 14.426556 | Text size: 40292 | Find: similardocuments

IDI-6273 waspurchased from ChemDiv.

Reverting iodine avidity of radioactive-iodine refractory thyroid cancerwith a new tyrosine kinase inhibitor (K905-0266) excavated by high-throughputNIS (sodium iodide symporter) enhancer screening platform using dual reportergene system

Ji Min Oh; SenthilkumarKalimuthu;Prakash Gangadaran; Se Hwan Baek; Liya Zhu; Ho Won Lee; Ramya LakshmiRajendran;Chae Moon Hong; Shin Young Jeong; Sang-Woo Lee; Jaetae Lee; Byeong-Cheol Ahn

PMC ID: PMC5805537 | DOI: 10.18632/oncotarget.24159 |Journal: Oncotarget, 9(1) pp. 7075-7087 |Publisher: Impact Journals LLC |Publication date: 2018-01-11

Originaldocument: PMC | Score: 14.117049 | Text size: 45448 | Find: similardocuments

K905-0266TKI was purchased from ChemDiv (San Diego, CA, USA) anddissolved in dimethyl sulfoxide (DMSO) and stored at −80°C.

Jian Ping Du; Lin Li; Jun Zheng; Ding Zhang; Wei Liu; Wei Hong Zheng; Xiao Song Li; Ru Cheng Yao; Fangyu Wang; Sen Liu; Xiao Tan

PMC ID: PMC5849182 | DOI: 10.18632/oncotarget.24132 |Journal: Oncotarget, 9(1) pp. 12894-12906 | Publisher: Impact Journals LLC |Publication date: 2018-01-10

Originaldocument: PMC | Score: 16.44229 | Text size: 45197 | Find: similardocuments

In silicoscreening of novel KLK7 inhibitors The 1,044,623 molecules in the ChemDiv databasewere prepared in Pipeline Pilot to generate 3-D conformations and minimized(Figure 5). ... Experimental validation of novel KLK7 inhibitors The 300compounds purchased from the ChemDiv library were evaluatedfor the in vitro inhibition of KLK7 by measuring the hydrolysis of the FRET

Polarized actin and VE-cadherin dynamics regulate junctional remodellingand cell migration during sprouting angiogenesis

Jiahui Cao; Manuel Ehling; Sigrid März; Jochen Seebach; KatsiarynaTarbashevich; Tomas Sixta; Mara E.Pitulescu;Ann-CathrinWerner;Boris Flach;Eloi Montanez; Erez Raz; Ralf H. Adams; Hans Schnittler

PMC ID: PMC5738342 | DOI: 10.1038/s41467-017-02373-8 |Journal: Nature Communications, 8(1) | Publisher: NaturePublishing Group UK |Publication date: 2017-12-20

Originaldocument: PMC | Score: 13.104898 | Text size: 94651 | Find: similardocuments

purchasedfrom Calbiochem (Bad Soden, Germany), and the active inhibitor CK548 waspurchased fromChemDiv (#K205-1650, San Diego, USA). Regents were usedat concentrations as indicated in the text.

Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23Hmouse model of retinitis pigmentosa

Paul A Nakamura; Andy A Shimchuk; Shibing Tang; Zhizhi Wang; Kole DeGolier; Sheng Ding; Thomas A Reh; Jeremy Nathans

PMC ID: PMC5693111 | DOI: 10.7554/eLife.30577 |Journal: eLife, 6(1) | Publisher: eLifeSciences Publications, Ltd | Publicationdate: 2017-11-17

Originaldocument: PMC | Score: 17.52101 | Text size: 49512 | Find: similardocuments

LaboratoryJackson Stock No: 000664; RRID:IMSR_JAX:000664 Chemical compound Photoregulin3(PR3)ChemDiv, and then synthesized in Ding Lab PubChem CID: 2092851Chemical compound Photoregulin1 (PR1)ChemDiv, and then synthesized inDing Lab PubChem CID: 7901316 Antibody Anti- Rhodopsin (Rho4D2), mouse ... Itwas initially obtained from ChemDiv and then synthesized andpurified in large quantities in the lab after initial screening.

A novel Fer/FerT targeting compound selectively evokes metabolic stressand necrotic death in malignant cells

Yoav Elkis; Moshe Cohen; Etai Yaffe; ShirlySatmary-Tusk; Tal Feldman; Elad Hikri; Abraham Nyska; Ariel Feiglin; Yanay Ofran; Sally Shpungin; Uri Nir

PMC ID: PMC5643328 | DOI: 10.1038/s41467-017-00832-w |Journal: Nature Communications, 8(1) | Publisher: Nature Publishing Group UK |Publication date: 2017-10-16

Originaldocument: PMC | Score: 15.367116 | Text size: 95412 | Find: similardocuments

robot, andapplied for screening a library comprised of 100,000 synthetic compounds (ChemDiv,USA). ... E260 was also computationally analyzed using the ChemSoft software (ChemDiv,USA) and proven to possess drug-likeness according to the Lipinski’s rule of 561.

Nanoparticulate vacuolar ATPase blocker exhibits potent host-targetedantiviral activity against feline coronavirus

Che-Ming Jack Hu; Wei-Shan Chang; Zih-Syun Fang; You-Ting Chen; Wen-Lin Wang; Hsiao-Han Tsai; Ling-Ling Chueh; Tomomi Takano; Tsutomu Hohdatsu; Hui-Wen Chen

PMC ID: PMC5638965 | DOI: 10.1038/s41598-017-13316-0 |Journal: Scientific Reports, 7(1) | Publisher: NaturePublishing Group UK |Publication date: 2017-10-12

Originaldocument: PMC | Score: 13.996932 | Text size: 51246 | Find: similardocuments

Diphyllinand diphyllin-encapsulated nanoparticles Diphyllin (ChemDiv, San Diego,CA) and bafilomycin A1 (Sigma) were dissolved in dimethyl sulfoxide (DMSO,Sigma).

Novel direct AMPK activator suppresses non-small cell lung cancer throughinhibition of lipid metabolism

Xi Chen; Chun Xie; Xing-Xing Fan; Ze-Bo Jiang; Vincent Kam-WaiWong;Jia-Hui Xu; Xiao-Jun Yao; Liang Liu; Elaine Lai-HanLeung

PMC ID: PMC5707083 | DOI: 10.18632/oncotarget.21716 |Journal: Oncotarget, 8(1) pp. 96089-96102 | Publisher: Impact Journals LLC |Publication date: 2017-10-09

Original document: PMC | Score: 13.878843 | Text size: 55446 | Find: similardocuments

MATERIALSAND METHODS Materials The compound library consisting 74 compounds werepurchased fromChemDiv (San Diego, CA, USA).

Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treginduction in mice

ToshiharuOnodera;AtsunoriFukuhara;Jihoon Shin; TomonoriHayakawa;Michio Otsuki; IichiroShimomura

PMC ID: PMC5496870 | DOI: 10.1038/s41598-017-04474-2 |Journal: Scientific Reports, 7(1) | Publisher: NaturePublishing Group UK |Publication date: 2017-07-04

Originaldocument: PMC | Score: 13.996932 | Text size: 45088 | Find: similardocuments

GPR119antagonist TM43718 was purchased as E897-0145 from ChemDiv (SanDiego, CA, USA).

Identification of Direct Activator of Adenosine Monophosphate-ActivatedProtein Kinase (AMPK) by Structure-Based Virtual Screening and MolecularDocking Approach

Tonghui Huang; Jie Sun; Shanshan Zhou; Jian Gao; Yi Liu

PMC ID: PMC5535900 | DOI: 10.3390/ijms18071408 |Journal: International Journal of Molecular Sciences, 18(1) | Publisher: MDPI |Publicationdate: 2017-06-30

Originaldocument: PMC | Score: 18.617102 | Text size: 32937 | Find: similardocuments

A chemicallibrary containing with 1,500,000 commercially available compounds (ChemDiv database)was docked to the molecular models of α1β1γ1 and α2β1γ1 AMPKisoforms in silico, respectively. Prior to docking, the ChemDiv databasewas split into eight subsets for molecular docking. ... The ChemDiv databasewas supplied by Topscience Co. ... Figure 5 Structures of retrieved hitstargeting α1β1γ1 AMPK isoformfromChemDiv database. Figure 6 The binding modes of typical hitcompounds for α1β1γ1 AMPKisoform. ... Figure 7 Structures of retrieved hits targeting α2β1γ1 AMPKisoform from ChemDiv database. Figure 8 The binding modes oftypical activators for α2β1γ1 AMPKisoform.

Identification of benzazole compounds that induce HIV-1 transcription

Jason D. Graci; Daniel Michaels; Guangming Chen; Gillian M.Schiralli Lester; Sarah Nodder; Marla Weetall; Gary M. Karp; Zhengxian Gu; Joseph M.Colacino;Andrew J.Henderson;Fatah Kashanchi

PMC ID: PMC5489165 | DOI: 10.1371/journal.pone.0179100 |Journal: PLoS ONE, 12(1) | Publisher: PublicLibrary of Science | Publicationdate: 2017-06-28

Originaldocument: PMC | Score: 13.878843 | Text size: 63610 | Find: similardocuments

Compound 1,2-(4-(5-amino-1H-benzimidazol-2-yl)phenyl)benzoxazol-5-amine, was acquiredfrom ChemDiv(San Diego, CA). Compounds 2–6 were synthesized at PTCTherapeutics, Inc.

3D Pharmacophore-Based Virtual Screening and Docking Approaches towardthe Discovery of Novel HPPD Inhibitors

Ying Fu; Yi-Na Sun; Ke-Han Yi; Ming-Qiang Li; Hai-Feng Cao; Jia-Zhong Li; Fei Ye; AlessandroPedretti

PMC ID: PMC6152767 | DOI: 10.3390/molecules22060959 |Journal: Molecules : A Journal of Synthetic Chemistry andNatural Product Chemistry, 22(1) | Publisher: MDPI | Publication date: 2017-06-09

Originaldocument: PMC | Score: 19.086233 | Text size: 32321 | Find: similardocuments

The ChemDiv databasewas screened using CBP-Hypo2 as a 3D query, and the best-fit hits subjected tomolecular ... HPPD inhibitors pharmacophore model molecule docking HipHop modelvirtual screeningChemDiv 1. Introduction Weeds compete with cropsfor sunshine, water, nutrients, and space, which ... having inhibitory activityagainst HPPD based on receptor, CBP-Hypo2 was used to screen the ChemDiv libraryto find potential HPPD inhibitors and Fit Value was selected as an importantcriterion. The hydrophobic groups (benzene and methyl) of the four compoundsobtained from the ChemDiv database formed hydrophobicinteractions with Met314 and Pro205, and the intermediate aromatic ring

A covalent PIN1 inhibitor selectively targets cancer cells by a dualmechanism of action

Elena Campaner; AlessandraRustighi;AlessandroZannini;AlbertoCristiani;Silvano Piazza; Yari Ciani; Ori Kalid; Gali Golan; Erkan Baloglu; Sharon Shacham; BarbaraValsasina;Ulisse Cucchi; Agnese ChiaraPippione;Marco LucioLolli;Barbara Giabbai; Paola Storici; Paolo Carloni; Giulia Rossetti; FedericaBenvenuti;Ezia Bello; MaurizioD'Incalci;ElisaCappuzzello;Antonio Rosato; Giannino Del Sal

PMC ID: PMC5472749 | DOI: 10.1038/ncomms15772 |Journal: Nature Communications, 8(1) | Publisher: NaturePublishing Group |Publication date: 2017-06-09

Originaldocument: PMC | Score: 15.963614 | Text size: 81154 | Find: similardocuments

Bionet (www.keyorganics.co.uk),Specs (www.specs.net), Chembridge (www.chembridge.com), ChemDiv(www.chemdiv.com)and Enamine (www.enamine.net). ... measurement 15 μl of Trypsin50 mg ml−1 (Sigma) and 5 μl of Suc-AEPF-MCA peptide 100 μg ml−1 (ChemDiv)in TFE LiCl 480 mM were added and the solutions mixed.

Comparative functional genomic screens of three yeast deletioncollections reveal unexpected effects of genotype in response to diverse stress

Erica Acton; Amy Huei-Yi Lee; Pei Jun Zhao; StephaneFlibotte;Mauricio Neira; Sunita Sinha; Jennifer Chiang; Patrick Flaherty; Corey Nislow; Guri Giaever

PMC ID: PMC5493772 | DOI: 10.1098/rsob.160330 |Journal: Open Biology, 7(1) | Publisher: The RoyalSociety | Publicationdate: 2017-06-07

Originaldocument: PMC | Score: 14.490094 | Text size: 61522 | Find: similardocuments

Screeningconcentrations for each compound (cisplatin (Toronto Research Chemicals), PCID16001701 (ChemDiv), CCCP (Sigma), FCCP (Sigma)) were determined byanalysing dose–response curves on wild-type

Screening of the ‘Open Scaffolds’ collection from Compounds Australiaidentifies a new chemical entity with anthelmintic activities against differentdevelopmental stages of the barber's pole worm and other parasitic nematodes☆

Sarah Preston; Yaqing Jiao; Jonathan B.Baell;Jennifer Keiser; Simon Crawford; Anson V. Koehler; Tao Wang; Moana M. Simpson; Ray M. Kaplan;Karla J. Cowley; Kaylene J.Simpson;Andreas Hofmann; Abdul Jabbar; Robin B. Gasser

PMC ID: PMC5517787 | DOI: 10.1016/j.ijpddr.2017.05.004 |Journal: International Journal for Parasitology: Drugs and DrugResistance, 7(1) pp. 286-294 | Publisher: Elsevier | Publication date: 2017-05-28

Originaldocument: PMC | Score: 14.363574 | Text size: 46349 | Find: similardocuments

microfilariaeof B. malayi A compound with known activity against H. contortus was purchasedfrom ChemDiv(USA) and then dissolved in DMSO to reach a stockconcentration of 30 mM, and then tested for its

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonasaeruginosa after Quorum Sensing Inhibitor Treatment

GiuseppeAllegretta;Christine K.Maurer;Jens Eberhard; Damien Maura; Rolf W. Hartmann; Laurence Rahme; Martin Empting

PMC ID: PMC5442231 | DOI: 10.3389/fmicb.2017.00924 |Journal: Frontiers in Microbiology, 8(1) | Publisher: FrontiersMedia S.A. |Publication date: 2017-05-24

Originaldocument: PMC | Score: 14.117049 | Text size: 45945 | Find: similardocuments

Thetricyclic 3 (Figure 2) and amitriptyline were purchased from ChemDiv (UnitedStates) and Alfa Aesar (Germany), respectively.

Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity

Joseph S.Bednash;NathanielWeathington;James Londino; Mauricio Rojas; Dexter L. Gulick; Robert Fort; SeungHye Han; Alison C.McKelvey;Bill B. Chen; Rama K.Mallampalli

PMC ID: PMC5437278 | DOI: 10.1038/ncomms15203 |Journal: Nature Communications, 8(1) | Publisher: NaturePublishing Group |Publication date: 2017-05-11

Originaldocument: PMC | Score: 13.317075 | Text size: 66892 | Find: similardocuments

The top 10score-ranking molecules were synthesized by a contract research organization (ChemDiv)and further tested in cell based and in vitro models.

Identification of Antifungal H+-ATPase Inhibitors with Effect on PlasmaMembrane Potential

Lasse Kjellerup; Sandra Gordon; Karen O'HanlonCohrt;William DalbyBrown;Anja ThoeFuglsang;Anne-Marie L.Winther

Originaldocument: PMC | Score: 13.76273 | Text size: 53127 | Find: similardocuments

Key Organics(13,681 compounds; Cornwall, UK), ChemBridge (63,042 compounds; San Diego,CA), ChemDiv Inc. (34,000 compounds; San Diego, CA), InterBioScreen(24,072 compounds; Chernogolovka, Russia), Specs

Comparative analyses of structural features and scaffold diversity forpurchasable compound libraries

Jun Shang; Huiyong Sun; Hui Liu; Fu Chen; Sheng Tian; Peichen Pan; Dan Li; Dexin Kong; Tingjun Hou

PMC ID: PMC5400773 | DOI: 10.1186/s13321-017-0212-4 |Journal: Journal of Cheminformatics, 9(1) | Publisher: Springer International Publishing | Publication date: 2017-04-21

Originaldocument: PMC | Score: 19.467783 | Text size: 54464 | Find: similardocuments

compoundlibraries deposited in ZINC15 were chosen in the analysis, and they are Mcule,Enamine, ChemDiv, VitasM, UORSY, ChemBridge, LifeChemicals,ZelinskyInstitute, Specs, ChemicalBlock and Maybridge. ... 4,922,295 4,876,889Large, individual service Enamine 1,959,026 1,958,807 Lead-like, diverse ChemDiv1,741,8071,741,603 Selected VitasM 1,460,248 1,460,009 Novel compounds UORSY 1,301,0921,293,353 ... 105,467 964 125,082 514,422 41,024 493,990 1255 85 543 345025,788 107,898 ChemDiv 103,562 440 129,997 512,142 40,933369,011 2021 69 784 3493 21,875 93,439 ChemicalBlock 96,236 1204 ... chains(3543) is at the average level, which is still higher than those of ChemBridge(3450) and ChemDiv (3493). However, Chembridge and ChemDiv bearthe top two numbers of chains (>510,000).

Cytotoxicity of Zardaverine in Embryonal Rhabdomyosarcoma from a CostelloSyndrome Patient

Donna M.Cartledge;Katherine M.Robbins;Katherine M.Drake;Rachel Sternberg; Deborah L.Stabley;Karen W. Gripp; E. Anders Kolb; Katia Sol-Church; Andrew D. Napper

PMC ID: PMC5376947 | DOI: 10.3389/fonc.2017.00042 |Journal: Frontiers in Oncology, 7(1) | Publisher: Frontiers Media S.A. | Publicationdate: 2017-04-03

Originaldocument: PMC | Score: 13.42576 | Text size: 69015 | Find: similardocuments

followingzardaverine analogs were supplied through Ryan Scientific (Mount Pleasant, SC,USA): ChemDivD216-0257, D216-0505, and D216-0543; Life ChemicalsF1967-0306 and F1967-0458; Specs

Identification of a small molecule inhibitor that stalls splicing at anearly step of spliceosome activation

AnzhalikaSidarovich;Cindy L Will; Maria M Anokhina; Javier Ceballos; Sonja Sievers; Dmitry EAgafonov;Timur Samatov; Penghui Bao; Berthold Kastner; Henning Urlaub; Herbert Waldmann; ReinhardLührmann; Timothy W Nilsen

PMC ID: PMC5354520 | DOI: 10.7554/eLife.23533 |Journal: eLife, 6(1) | Publisher: eLifeSciences Publications, Ltd | Publicationdate: 2017-03-16

Originaldocument: PMC | Score: 16.041449 | Text size: 117036 | Find: similardocuments

pyrimidine-2,4,6(1H,3H,5H)-trione (synthesized in-house or purchased from ChemDiv,cat. no. 3679-1153) dissolved in DMSO, and were incubated at 30°C for theindicated times. ... (2277–0005), 164502 (0327–0135), 344340 (0327–0183) and344341 (0327–0199) were purchased from ChemDiv (catalog numberin parentheses) and their purity was determined by HPLC-MS prior to use.

Identification of a small molecule inhibitor that stalls splicing at anearly step of spliceosome activation

PMC ID: PMC5354520 | DOI: 10.7554/eLife.23533 |Journal: eLife, 6(1) | Publisher: eLifeSciences Publications, Ltd | Publicationdate: 2017-03-16

Originaldocument: PMC | Score: 15.2631445 | Text size: 4095 | Find: similardocuments

splicing andalso provide the catalogue numbers for all of the compounds that we purchasedfrom ChemDiv.

Inhibitor SBFI26 suppresses the malignant progression ofcastration-resistant PC3-M cells by competitively binding to oncogenic FABP5

Waseem Al-Jameel; Xiaojun Gou; Shiva S.Forootan;Majed Saad AlFayi;Philip S.Rudland;Farzad S.Forootan;Jiacheng Zhang; Philip A.Cornford;Syed A. Hussain; Youqiang Ke

PMC ID: PMC5458187 | DOI: 10.18632/oncotarget.16055 |Journal: Oncotarget, 8(1) pp. 31041-31056 |Publisher: Impact Journals LLC |Publication date: 2017-03-09

Originaldocument: PMC | Score: 13.996932 | Text size: 56836 | Find: similardocuments

SBFI19 (cat#5511-0235), SBFI27 (cat# 8009-7646) and SBFI31 (cat# C075-0064) were purchasedfromChemDiv, dissolved in DMSO, and stored at –20°C.

A high-throughput phenotypic screen identifies clofazimine as a potentialtreatment for cryptosporidiosis

Melissa S. Love; Federico C.Beasley;Rajiv S. Jumani; Timothy M.Wright;Arnab K.Chatterjee;Christopher D.Huston;Peter G. Schultz; Case W. McNamara; Timothy G. Geary

Originaldocument: PMC | Score: 13.648543 | Text size: 64131 | Find: similardocuments

powders(> 95% purity) from Selleck Chemicals, Calbiochem, Ambinter, Enzo LifeSciences, NCI, ChemDiv, or Life Chemicals.

Discovery of Novel Small Molecule Inhibitors of VEGF Expression in TumorCells Using a Cell-Based High Throughput Screening Platform

Liangxian Cao; Marla Weetall; Jenelle Bombard; Hongyan Qi; Tamil Arasu; William Lennox; Jean Hedrick; Josephine Sheedy; Nicole Risher; Peter C. Brooks; PanayiotaTrifillis;ChristopherTrotta;Young-Choon Moon; John Babiak; Neil G. Almstead; Joseph M.Colacino;Thomas W. Davis; Stuart W. Peltz; Thomas Preiss

PMC ID: PMC5161367 | DOI: 10.1371/journal.pone.0168366 |Journal: PLoS ONE, 11(1) | Publisher: PublicLibrary of Science | Publicationdate: 2016-12-16

Originaldocument: PMC | Score: 13.648543 | Text size: 62792 | Find: similardocuments

were chosenand commercially purchased from several vendors, including about 80,000compounds fromChemDiv (San Diego, CA), 30,000 from Coelacanthchemical (New Jersey), 37,000 from ChemBridge corporation

Structural Characterization and Ligand/Inhibitor Identification Provide FunctionalInsights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1*

Jude T. Chenge; Le Van Duyet; Shalini Swami; Kirsty J. McLean; Madeline E.Kavanagh;Anthony G. Coyne; Stephen E. J.Rigby;Myles R.Cheesman;Hazel M. Girvan; Colin W. Levy; Bernd Rupp; Jens P. vonKries;Chris Abell; David Leys; Andrew W. Munro

Originaldocument: PMC | Score: 15.81019 | Text size: 103371 | Find: similardocuments

wereidentified as “hits,” and the top ranking compounds were purchased, whereavailable, from ChemDiv (San Diego, CA) or Vitas M (Apeldoorn,The Netherlands). ... Medicinal Chemistry, Leibniz Institute of MolecularPharmacology (Berlin, Germany) or sourced from ChemDiv orVitas M. Bacterial growth medium (2xYT) was from Melford Laboratories (Ipswich,Suffolk, UK).

Identification of a novel Polo-like kinase 1 inhibitor that specificallyblocks the functions of Polo-Box domain

Yunyu Chen; Jing Zhang; Dongsheng Li; Jiandong Jiang; Yanchang Wang; Shuyi Si

PMC ID: PMC5352051 | DOI: 10.18632/oncotarget.13603 |Journal: Oncotarget, 8(1) pp. 1234-1246 |Publisher: Impact Journals LLC |Publication date: 2016-11-25

Originaldocument: PMC | Score: 16.279572 | Text size: 52079 | Find: similardocuments

From arandom compound library purchased from ChemDiv (20,000compounds), T521 was identified as a potent Plk1 PBD inhibitor with an IC50 of1.22±0. ... potent Plk1 PBD inhibitor from the diverse chemical libraries of20,000 small-molecule compounds (ChemDiv). Because a large amount ofT521 was needed for its characterization, we designed chemical

Three-Dimensional Biologically Relevant Spectrum (BRS-3D): ShapeSimilarity Profile Based on PDB Ligands as Molecular Descriptors

Ben Hu; Zheng-Kun Kuang; Shi-Yu Feng; Dong Wang; Song-Bing He; De-Xin Kong; James W. Gauld

PMC ID: PMC6273508 | DOI: 10.3390/molecules21111554 |Journal: Molecules, 21(1) | Publisher: MDPI | Publication date: 2016-11-17

Originaldocument: PMC | Score: 14.426556 | Text size: 67349 | Find: similardocuments

virtualscreening contained more than 300,000 drug-like or lead-like compounds derivedfrom Specs,ChemDiv, and Enamine.

Phenylphthalazines as small-molecule inhibitors of urea transporter UT-Band their binding model

Jian-hua Ran; Min Li; Weng-Ieong Tou; Tian-luo Lei; Hong Zhou; Calvin Yu-ChianChen;Bao-xue Yang

Originaldocument: PMC | Score: 16.524874 | Text size: 43068 | Find: similardocuments

primaryscreening was performed using a collection of 10 000 diverse, drug-likecompounds from ChemDiv, Inc (San Diego, CA, USA), and 96-wellplates containing a single compound per well (2. ... Structure-activityrelationship Approximately 160 commercially available analogs (ChemDiv Inc,San Diego, CA, USA) of active compounds identified in the primary screeningwere tested against

Ani9, A Novel Potent Small-Molecule ANO1 Inhibitor with Negligible Effecton ANO2

Yohan Seo; Ho K. Lee; Jinhong Park; Dong-kyu Jeon; Sungwoo Jo; Minjae Jo; Wan Namkung; Alexander A.Mongin

PMC ID: PMC4878759 | DOI: 10.1371/journal.pone.0155771 |Journal: PLoS ONE, 11(1) | Publisher: PublicLibrary of Science | Publicationdate: 2016-05-24

Originaldocument: PMC | Score: 16.360525 | Text size: 47331 | Find: similardocuments

Ani9 and itsanalogs were purchased from ChemDiv (San Diego, CA).Recombinant Human IL-4 was purchased from R&D systems (Minneapolis, MN).The compound collections used for screening included 54,400 drug-like moleculeswere purchased from ChemDiv.

Pharmit: interactive exploration of chemical space

Jocelyn Sunseri; David Ryan Koes

Originaldocument: PMC | Score: 14.951023 | Text size: 28906 | Find: similardocuments

Pharmit haspre-built libraries generated from CHEMBL21 (10), with >1.4 millioncompounds; ChemDiv(www.chemdiv.com), with >1.4 millioncompounds; MolPort (www.molport.com), with >6.

Structure–Activity Relationship for the 4(3H)-QuinazolinoneAntibacterials

Renee Bouley; Derong Ding; Zhihong Peng; Maria Bastian; Elena Lastochkin; Wei Song; Mark A. Suckow; Valerie A.Schroeder;William R.Wolter;ShahriarMobashery;Mayland Chang

Originaldocument: PMC | Score: 13.648543 | Text size: 65531 | Find: similardocuments

72quinazolinone derivatives (Scheme 1), and an additional 5 compounds werepurchased from ChemDiv.

Imbalance in chemical space: How to facilitate the identification ofprotein-protein interaction inhibitors

MélaineA. Kuenemann; Céline M.Labbé; Adrien H. Cerdan; Olivier Sperandio

PMC ID: PMC4817116 | DOI: 10.1038/srep23815 |Journal: Scientific Reports, 6(1) | Publisher: NaturePublishing Group | Publication date:2016-04-01

Originaldocument: PMC | Score: 13.996932 | Text size: 70381 | Find: similar documents

fromcommercial databases BDM 39,186 Compounds from commercial databases(Asinex, ChemDiv and Enamine) Table 2 All of the names of the2D descriptors and their description.

Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), aResistance Mechanism for Two Distinct Compound Classes

Pamela A.Magistrado;Victoria C.Corey;Amanda K. Lukens; Greg LaMonte; Erika Sasaki; Stephan Meister; Melanie Wree; ElizabethWinzeler;Dyann F. Wirth

Originaldocument: PMC | Score: 14.2392435 | Text size: 56141 | Find: similardocuments

10(C776-3585), 11 (C776-3587), 12 (C776-3670), 13 (C776-3575), and 14 (C776-3628)were from ChemDiv, USA; quinine, atovaquone, and mefloquine were fromSigma-Aldrich, USA.

Structure-Based Drug Design of Small Molecule Peptide DeformylaseInhibitors to Treat Cancer

Jian Gao; Tao Wang; Shengzhi Qiu; Yasheng Zhu; Li Liang; Youguang Zheng; Derek J. McPhee

PMC ID: PMC6273975 | DOI: 10.3390/molecules21040396 |Journal: Molecules, 21(1) | Publisher: MDPI | Publication date: 2016-03-23

Originaldocument: PMC | Score: 16.863674 | Text size: 32414 | Find: similardocuments

the crystalstructure (3G5K) was utilized to screen the HsPDF inhibitors from theTopscience ChemDivdatabase (commercially available). ... The smallmolecule database was the ChemDiv database (commerciallyavailable) from Topscience Co.

Global Survey of Cell Death Mechanisms Reveals Metabolic Regulation ofFerroptosis

Kenichi Shimada; Rachid Skouta; Anna Kaplan; Wan Seok Yang; Miki Hayano; Scott J. Dixon; Lewis M. Brown; Carlos A.Valenzuela;Adam J. Wolpaw;Brent R.Stockwell

Originaldocument: PMC | Score: 13.648543 | Text size: 66174 | Find: similar documents

compounds,as well as structural analogs of CIL41/70, were purchased from Asinex,ChemBridge, ChemDiv, Enamine, InterBioScreen, MayBridge, TimTec,Vitas M Labs, and Zelinsky.

Nuclear envelope expansion is crucial for proper chromosomal segregationduring a closed mitosis

Ai Takemoto; Shigehiro A.Kawashima;Juan-Juan Li; Linda Jeffery; Kenzo Yamatsugu; Olivier Elemento; Paul Nurse

Originaldocument: PMC | Score: 16.524874 | Text size: 52513 | Find: similardocuments

In the end,the collection of 30 plates contained 2112 ChemDiv (San Diego,CA) compounds, 352 AMRI (Albany, NY) compounds, 5280 Enamine (Kiev, Ukraine)compounds, ... Registry Number: 53296-08-5), and Cutin-2 (CAS Registry Number:957489-42-8) were purchased from ChemDiv (San Diego, CA).

Small molecule inhibitors of the Dishevelled‐CXXC5interaction are new drug candidates for bone anabolic osteoporosis therapy

Hyun‐Yi Kim; Sehee Choi; Ji‐Hye Yoon; Hwan Jung Lim; Hyuk Lee; Jiwon Choi; Eun Ji Ro; Jung‐Nyoung Heo; Weontae Lee; Kyoung Tai No; Kang‐Yell Choi

Originaldocument: PMC | Score: 13.996932 | Text size: 52543 | Find: similardocuments

of KoreaResearch Institute of Chemical Technology (Daejeon, Korea) or were purchasedfrom ChemDiv Inc.(San Diego, CA).

Identification of Adjuvantic Activity of Amphotericin B in a Novel,Multiplexed, Poly-TLR/NLR High-Throughput Screen

Alex C. D.Salyer;Giuseppe Caruso; Karishma K.Khetani;Lauren M. Fox; Subbalakshmi S.Malladi;Sunil A. David; SuryaprakashSambhara

PMC ID: PMC4769227 | DOI: 10.1371/journal.pone.0149848 |Journal: PLoS ONE, 11(1) | Publisher: PublicLibrary of Science | Publicationdate: 2016-02-26

Originaldocument: PMC | Score: 14.301138 | Text size: 49042 | Find: similardocuments

HighThroughput Screening laboratory which include Life Chemicals (15,040),ChemBridge (43,736), ChemDiv(56,232), Selleck Bioactives (1649),TimTec (5000), and FDA Repurposed Library (2,286) were used.

In Silico Screening, Alanine Mutation, and DFT Approaches forIdentification of NS2B/NS3 Protease Inhibitors

R. Balajee; V.Srinivasadesikan; M. Sakthivadivel; P. Gunasekaran

Originaldocument: PMC | Score: 18.879087 | Text size: 43739 | Find: similardocuments

Ligand5PubChem −38.16 1.29 6 Ligand6 PubChem −44.67 33.89 7 Ligand7PubChem −45.83 0.1 8 Ligand8ChemDiv −48.40 15.6 9Ligand9 ChemDiv −44.21 86.7 10 Ligand10 ChemDiv −31.3432.2 11 Ligand11ChemDiv −41.67 12.5 12 Ligand12 ChemDiv −39.143.9 13 Ligand13 ChemDiv −39.09 26.4 14 Ligand14ChemDiv −51.3175.3 15 Ligand15 PubChem −42.52 0.12 16 Ligand16 PubChem −31.57 4.717 Ligand17 PubChem −35.

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

Laetitia J.Martin;Manfred Koegl; Gerd Bader; Xiao-LingCockcroft;Oleg Fedorov; Dennis Fiegen; ThomasGerstberger;Marco H. Hofmann; Anja F. Hohmann; Dirk Kessler; Stefan Knapp; Petr Knesl; Stefan Kornigg; SusanneMüller;Herbert Nar; Catherine Rogers; Klaus Rumpel; Otmar Schaaf;Steffen Steurer; Cynthia Tallant; Christopher R.Vakoc;Markus Zeeb; Andreas Zoephel; Mark Pearson; Guido Boehmelt; Darryl McConnell

Originaldocument: PMC | Score: 13.76273 | Text size: 57065 | Find: similardocuments

Compound 3is commercially available from, e.g., ChemDiv.

Targeting BRCA1- and BRCA2-deficient cells with RAD52 small moleculeinhibitors

Fei Huang; Nadish Goyal; KatherineSullivan;KritikaHanamshet;Mikir Patel; Olga M. Mazina; Charles X. Wang; W. Frank An; James Spoonamore;Shailesh Metkar; Kyle A. Emmitte; Simon Cocklin; Tomasz Skorski; Alexander V.Mazin

Originaldocument: PMC | Score: 13.878843 | Text size: 52951 | Find: similardocuments

Thecompounds for confirmation analysis were purchased from Asinex Ltd., ChemBridgeCo., ChemDiv Inc, Enamine, FCH Group, Frontier Scientific ServicesInc., InterBioScreen Ltd., Life Chemicals Inc.

DDRI-9: a novel DNA damage response inhibitor that blocks mitoticprogression

Dong Wha Jun; Mihwa Hwang; Yun-Hee Kim; Kyung-Tae Kim; Sunshin Kim; Chang-Hun Lee

PMC ID: PMC4951243 | DOI: 10.18632/oncotarget.7135 |Journal: Oncotarget, 7(1) pp. 17699-17710 |Publisher: Impact Journals LLC |Publication date: 2016-02-02

Originaldocument: PMC | Score: 14.2392435 | Text size: 39331 | Find: similardocuments

(C13H10FN5O4)was provided by the Korea Chemical Bank (Daejeon, Korea) or purchased fromeitherChemDiv (La Jolla, CA, USA) or Hanchem (Daejeon, Korea).

Small molecule screen for inhibitors of expression from canonical CREBresponse element-containing promoters

Bryan Mitton; Katie Hsu; Ritika Dutta; Bruce C. Tiu; Nick Cox; Kevin G. McLure; Hee-Don Chae; Mark Smith; Elizabeth A.Eklund;David E.Solow-Cordero; Kathleen M.Sakamoto

PMC ID: PMC4890994 | DOI: 10.18632/oncotarget.7085 |Journal: Oncotarget, 7(1) pp. 8653-8662 |Publisher: Impact Journals LLC |Publication date: 2016-01-30

Original document: PMC | Score: 16.777678 | Text size: 29614 | Find: similardocuments

Thiscollection was assembled from several commercial vendors, including ChemDiv,Specs, and Chembridge, and possesses drug-like qualities [7]. ... Thesecompounds are drug-like and were assembled from various commercial sourcesincluding, ChemDiv (60 K), Specs (30 K), and Chembridge (23.5K).

CFTR Activator Increases Intestinal Fluid Secretion and Normalizes StoolOutput in a Mouse Model of Constipation

Onur Cil; Puay-Wah Phuan; Sujin Lee; Joseph Tan; Peter M. Haggie; Marc H. Levin; Liang Sun; Jay R.Thiagarajah;Tonghui Ma; Alan S. Verkman

PMC ID: PMC4844355 | DOI: 10.1016/j.jcmgh.2015.12.010 |Journal: Cellular and Molecular Gastroenterology andHepatology, 2(1) pp. 317-327| Publisher: Elsevier | Publication date: 2016-01-09

Originaldocument: PMC | Score: 16.360525 | Text size: 45259 | Find: similardocuments

wasperformed using a diverse collection of 120,000 drug-like synthetic compoundsobtained from ChemDiv, Inc (San Diego, CA) and Asinex(Winston-Salem, NC). For structure-activity analysis, 600 commerciallyavailable analogs (ChemDiv, Inc) of active compounds identified in theprimary screen were tested.

Characterization of a Novel Human-Specific STING Agonist that ElicitsAntiviral Activity Against Emerging Alphaviruses

Tina M. Sali; Kara M. Pryke; Jinu Abraham; Andrew Liu; Iris Archer; Rebecca Broeckel; Julia A.Staverosky;Jessica L. Smith; AhmedAl-Shammari;Lisi Amsler; Kayla Sheridan; Aaron Nilsen; Daniel N.Streblow;Victor R. DeFilippis; Sara Cherry

Originaldocument: PMC | Score: 12.899377 | Text size: 100799 | Find: similardocuments

Stocks ofG10 were purchased from ChemDiv.

Improving drug discovery with high-content phenotypic screens bysystematic selection of reporter cell lines

Jungseog Kang; Chien-Hsiang Hsu; Qi Wu; Shanshan Liu; Adam D. Coster; Bruce A. Posner; Steven J.Altschuler;Lani F. Wu

Originaldocument: PMC | Score: 13.996932 | Text size: 71285 | Find: similardocuments

approximatingthe chemical diversity of the 230K institutional library that was purchasedfrom ChemDiv, ChemBridge, Comgenix, and TimTek).

Discovery of Small Molecules that Inhibit the Disordered Protein, p27Kip1

Luigi I. Iconaru; David Ban; KavithaBharatham;ArvindRamanathan;Weixing Zhang; Anang A. Shelat; Jian Zuo; Richard W.Kriwacki

PMC ID: PMC4623604 | DOI: 10.1038/srep15686 |Journal: Scientific Reports, 5(1) | Publisher: NaturePublishing Group | Publicationdate:2015-10-28

Originaldocument: PMC | Score: 13.996932 | Text size: 68110 | Find: similardocuments

for Group 1and 2 molecules were used to query a database of 10,455 fragment-like moleculesfrom ChemDiv(www.chemdiv.com) using the FIeldScreen module inForge.

Mechanism of Action and Initial, In Vitro SAR of an Inhibitor of theShigella flexneri Virulence Regulator VirF

Anthony A.Emanuele;George A. Garcia; Nicholas JMantis

PMC ID: PMC4564171 | DOI: 10.1371/journal.pone.0137410 |Journal: PLoS ONE, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-09-09

Originaldocument: PMC | Score: 14.117049 | Text size: 52411 | Find: similardocuments

(Moscow,Russia), while compounds 144092, 144143, 153578, and 24904 were purchasedfrom ChemDiv (San Diego, CA). Analogs of 19615 were purchasedthrough Aldrich Market Select (St. Louis, MO).

Chemical perturbation of an intrinsically disordered region of TFIIDdistinguishes two modes of transcription initiation

Zhengjian Zhang; Zarko Boskovic; Mahmud M Hussain; Wenxin Hu; Carla Inouye; Han-Je Kim; A KatherineAbole;Mary K Doud; Timothy A Lewis;Angela N Koehler; Stuart LSchreiber;Robert Tjian; Danny Reinberg

Originaldocument: PMC | Score: 19.331345 | Text size: 103808 | Find: similardocuments

Weidentified one compound (1, ChemDiv 7241-4207) thatreproducibly and selectively bound to both Drosophila and human TFIID (Figure... Yellow arrows denote the lead compound (1, ChemDiv 7241-4207).... We found that the commercially supplied compound 1 (ChemDiv 7241-4207)inhibited both Drosophila and human TFIID-directed transcription, but nottranscription ... transcription, but not TBP-directed transcription, by theoriginally purchased lead compound (1, ChemDiv 7241-4207). ...More specifically, ‘ChemDiv’ stands forChemDiv Inc. (SanDiego, CA); ‘Otava’ stands for Otava Ltd (Vaughan, Canada); ‘Princeton’ standsfor Princeton

Myosin 1b functions as an effector of EphB signaling to control cellrepulsion

Marie-ThérèseProspéri; PriscillaLépine; Florent Dingli; PerrinePaul-Gilloteaux; RenéMartin;Damarys Loew; Hans-JoachimKnölker; Evelyne Coudrier

Originaldocument: PMC | Score: 13.648543 | Text size: 68898 | Find: similardocuments

Drugtreatments 100 μm CK666 (ChemDiv,Inc.) in 0.1% DMSO, 50 μm blebbistatin (Sigma-Aldrich) in 0.3% DMSO, and 1 μm PCIP (giftfrom H.-J.

Overcoming Chemical, Biological, and Computational Challenges in theDevelopment of Inhibitors Targeting Protein-Protein Interactions

Luca Laraia; Grahame McKenzie; David R. Spring; Ashok R.Venkitaraman; David J. Huggins

Originaldocument: PMC | Score: 16.44229 | Text size: 93702 | Find: similardocuments

ChemDiv, Asinex,Comminex, Life Chemicals, Otava Chemicals, and NQuix all have librariestargeted at PPIs, ... NA NA http://nquix.com/screening-libraries ChemDiv 125,000peptidomimetics http://www.chemdiv.

Targeted inhibition of the Shroom3–Rho kinase protein–protein interactioncircumvents Nogo66 to promote axon outgrowth

Heather MDickson;Amanda Wilbur; Ashley A Reinke; Mathew A Young; Anne B Vojtek

PMC ID: PMC4467669 | DOI: 10.1186/s12868-015-0171-5 |Journal: BMC Neuroscience, 16(1) | Publisher: BioMed Central | Publicationdate: 2015-06-16

Originaldocument: PMC | Score: 17.397476 | Text size: 49546 | Find: similardocuments

The assaywas then optimized for high-throughput screening in 384-well plates. 20,000compounds (ChemDiv) were screened in the Center for Chemical Genomics atthe University of Michigan. ... with fresh powder 32 of the 36 hits from theprimary screen were available for purchase from ChemDiv andwere diluted in DMSO and stored at −20°C. ... (10 μM,Calbiochem, San Diego, CA, USA), a ROCK 1/2 inhibitor, or CCG-17444 (25 μM of3347-0032, ChemDiv, San Diego, CA, USA), were added to CGNs inculture media [DMEM (Invitrogen) supplemented with 2%

Identification of β-hematininhibitors in the MMV Malaria Box

Kim Y. Fong; Rebecca D.Sandlin;David W. Wright

PMC ID: PMC4486462 | DOI: 10.1016/j.ijpddr.2015.05.003 |Journal: International Journal for Parasitology: Drugs and Drug Resistance, 5(1) pp.84-91 |Publisher: Elsevier | Publicationdate: 2015-06-06

Originaldocument: PMC | Score: 14.2392435 | Text size: 42195 | Find: similardocuments

Malaria Box,the additional testing was conducted using compounds purchased from ChemBridgeandChemDiv.

New Small Molecules Targeting Apoptosis and Cell Viability inOsteosarcoma

Doris Maugg; Ina Rothenaigner; Kenji Schorpp; Harish KumarPotukuchi;EberhardKorsching;Daniel Baumhoer; Kamyar Hadian; Jan Smida;MichaelaNathrath;DominiqueHeymann

PMC ID: PMC4454490 | DOI: 10.1371/journal.pone.0129058 |Journal: PLoS ONE, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-06-03

Original document: PMC | Score: 13.76273 | Text size: 56891 | Find: similardocuments

The twocompounds found in the screening were obtained from ChemDiv (SanDiego, CA), and can be re-ordered using the compound IDs for A13 (compound ID:6228–2300) and

The enzyme activities of Caf1 and Ccr4 are both required fordeadenylation by the human Ccr4–Not nuclease module

Maryati Maryati; BlessingAirhihen;G. SebastiaanWinkler

Originaldocument: PMC | Score: 16.650314 | Text size: 42713 | Find: similardocuments

ChemDiv),NCC-00001590(N-[6-(isobutylsulfamoyl)-1,3-benzothiazol-2-yl]-2-methyl-benzamide; ChemDiv)and NCC-00039069

Structure–activity exploration of a small-molecule Lipid II inhibitor

Steven Fletcher; Wenbo Yu; Jing Huang; Steven M Kwasny; Jay Chauhan; Timothy JOpperman;Alexander DMacKerell;Erik PH de Leeuw

PMC ID: PMC4422293 | DOI: 10.2147/DDDT.S79504 |Journal: Drug Design, Development and Therapy, 9(1) pp. 2383-2394 | Publisher: Dove MedicalPress |Publicationdate: 2015-04-24

Originaldocument: PMC | Score: 18.75121 | Text size: 38458 | Find: similardocuments

ChemBridgeNo No 8005-4461 C14H16N 198.3 1,2,5-Trimethyl-4-phenylpyridinium ChemDiv NoNo 8005-4525 C14H14N3 224.3 1-Methyl-3-(1-methyl-1H-benzimidazol-2-yl)pyridinium ChemDiv NoNo 8005-4452 C14H17N2 213.3 1,2,5-Trimethyl-4-(phenylamino)pyridinium ChemDiv NoNo 0865-0038 C18H16N3 274.31,3-Dimethyl-2-(quinolin-2-yl)-1H-3,1-benzimidazol-3-lum ChemDiv NoNo 0865-0043 C14H14N 196.3 1-Methyl-2-[(E)-2-phenylethenyl]pyridinium ChemDiv NoNo 8009-7229 C23H22ClN3O 391.91-(4-Chlorophenyl)-3-methyl-4-[2-(1,3,3-trimethylindolin-2-ylidene)ethylidene]-1,2-diazolin-5-one ChemDiv NoNo Z56594936 C19H18BrNO 356.

Selective activators of protein phosphatase 5 target the auto-inhibitorymechanism

VeronikaHaslbeck;Adrian Drazic; Julia M. Eckl; Ferdinand Alte; Martin Helmuth; GrzegorzPopowicz;Werner Schmidt; Frank Braun; Matthias Weiwad; Gunter Fischer; Gerd Gemmecker; Michael Sattler; Frank Striggow; Michael Groll; Klaus Richter

Originaldocument: PMC | Score: 17.614815 | Text size: 49370 | Find: similardocuments

NewChemistry and Discovery Chemistry Collection consisting of 10000 compounds wasobtained fromChemDiv. Substances PP5 small-molecule activator (P5SA)-1,P5SA-2, P5SA-3, P5SA-4 and P5SA-5 were purchased from ChemDiv. ...compound library consisting of 10000 compounds (New Chemistry and DiscoveryChemistry Collection, ChemDiv) was screened using a chromometricphosphatase assay with para-nitrophenyl phosphate (pNPP) as

Identification of Selective Inhibitors of the Plasmodium falciparumHexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

Diana Ortiz; W. Armand Guiguemde; Alex Johnson; Carolyn Elya; Johanna Anderson; Julie Clark; Michele Connelly; Lei Yang; Jaeki Min; Yuko Sato; R. Kiplin Guy; Scott M.Landfear;Stuart AlexanderRalph

PMC ID: PMC4404333 | DOI: 10.1371/journal.pone.0123598 |Journal: PLoS ONE, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-04-20

Originaldocument: PMC | Score: 13.996932 | Text size: 51793 | Find: similardocuments

Compound 1and 10–15 were purchases from ChemDiv (San Diego, CA).

Structure- and Ligand-Based Virtual Screening Identifies New Scaffoldsfor Inhibitors of the Oncoprotein MDM2

Douglas R.Houston;Li-Hsuan Yen; Simon Pettit; Malcolm D.Walkinshaw;ManuelaHelmer-Citterich

PMC ID: PMC4401541 | DOI: 10.1371/journal.pone.0121424 |Journal: PLoS ONE, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-04-17

Originaldocument: PMC | Score: 14.5541935 | Text size: 46122 | Find: similardocuments

in SDFformat of ChemBridge, Asinex, Maybridge, Enamine, LifeChemicals, Specs,InterBioScreen, ChemDivand KeyOrganics were merged.

Discovery of Novel New Delhi Metallo-β-Lactamases-1 Inhibitors by Multistep Virtual Screening

Xuequan Wang; Meiling Lu; Yang Shi; Yu Ou; Xiaodong Cheng; Horacio Bach

PMC ID: PMC4348537 | DOI: 10.1371/journal.pone.0118290 |Journal: PLoS ONE, 10(1) | Publisher: PublicLibrary of Science | Publicationdate: 2015-03-03

Originaldocument: PMC | Score: 14.363574 | Text size: 44807 | Find: similardocuments

bindingsite, 44 molecules (Table B in S1 File) were ultimately selected and purchasedfrom the ChemDiv (San Diego, CA) for experimental validationusing in vitro assays.

In silico discovery and validation of potent small-molecule inhibitorstargeting the activation function 2 site of human oestrogen receptor α

Kriti Singh; Ravi ShashiNayana Munuganti; Eric Leblanc; Yu Lun Lin; Euphemia Leung; Nada Lallous; Miriam Butler; Artem Cherkasov; Paul S Rennie

Originaldocument: PMC | Score: 13.42576 | Text size: 75135 | Find: similardocuments

(San Diego,CA, USA; compounds VPC-16007, VPC-16003, VPC-16004, VPC-16222 andVPC-16223), ChemDiv(San Diego, CA, USA; compound VPC-16019), TimTec(Newark, DE, USA; compounds VPC-16041, VPC-16046,

A Serpin Shapes the Extracellular Environment to Prevent Influenza AVirus Maturation

Meike Dittmann; Hans-HeinrichHoffmann;Margaret A. Scull; Rachel H.Gilmore;Kierstin L. Bell; MichaelCiancanelli;Sam J. Wilson; Stefania Crotta; Yingpu Yu; Brenna Flatley; Jing W. Xiao; Jean-LaurentCasanova;Andreas Wack; Paul D. Bieniasz; Charles M. Rice

Originaldocument: PMC | Score: 13.317075 | Text size: 79183 | Find: similardocuments

Diphyllin (ChemDiv)was used to block IAV entry at 10 μM, and Ribavirin at 500 μM asreplication inhibition control,

Target validation and structure–activity analysis of a series of novelPCNA inhibitors

Kelsey LDillehay;William L Seibel; Daoli Zhao; Shan Lu; Zhongyun Dong

Originaldocument: PMC | Score: 14.301138 | Text size: 40221 | Find: similardocuments

SAR-15 andSAR-16 were purchased from ChemDiv (San Diego, CA).

Automated High-Content Assay for Compounds Selectively Toxic toTrypanosoma cruzi in a Myoblastic Cell Line

JulioAlonso-Padilla; Ignacio Cotillo; Jesús L.Presa;Juan Cantizani; ImanolPeña;Ana I. Bardera; Jose J.Martín; Ana Rodriguez; Genevieve Milon

Originaldocument: PMC | Score: 14.117049 | Text size: 52266 | Find: similardocuments

mesylate(Tocris Bioscience), hydrazide derivative PCH1 (InterBioScreen), LP10 (ChemDiv),loperamide (Enamine), posaconazole (Sheckchem.

Compounds targeting disulfide bond forming enzyme DsbB of Gram-negativebacteria

Cristina Landeta; Jessica L.Blazyk;Feras Hatahet; Brian M. Meehan; Markus Eser; Alissa Myrick; LudmilaBronstain;Shoko Minami; Holly Arnold;Na Ke; Eric J. Rubin; Barbara C. Furie; Bruce Furie; Jon Beckwith; Rachel Dutton; Dana Boyd

Originaldocument: PMC | Score: 13.648543 | Text size: 68715 | Find: similar documents

50,374compounds from several commercial small molecule libraries (Asinex 1,ChemBridge 3, ChemDiv 4, Life Chemicals 1, and Enamine 2) andsmall libraries of known bioactive molecules and natural

Novel PDE4 Inhibitors Derived from Chinese Medicine Forsythia

Tiffany A. Coon; Alison C.McKelvey;Nate M.Weathington;Rahel L. Birru; Travis Lear; George D.Leikauf;Bill B. Chen; Min Wu

PMC ID: PMC4280171 | DOI: 10.1371/journal.pone.0115937 |Journal: PLoS ONE, 9(1) | Publisher: PublicLibrary of Science | Publicationdate: 2014-12-30

Original document: PMC | Score: 14.363574 | Text size: 34844 | Find: similardocuments

Forsythinwas from Stanford Chemicals; all other synthetic compounds were purchasedfrom ChemDiv, Inc.and Vitas-M Laboratory, Ltd. All compounds are>98% pure by HPLC.

A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS AutoimmuneInflammatory Disease

Kareem L. Graham; Jian V. Zhang; SusannaLewén; Thomas M. Burke; Ton Dang; Maria Zoudilova; Raymond A. Sobel; Eugene C.Butcher;Brian A. Zabel; Michael Platten

PMC ID: PMC4249827 | DOI: 10.1371/journal.pone.0112925 |Journal: PLoS ONE, 9(1) | Publisher: PublicLibrary of Science | Publicationdate: 2014-12-01

Originaldocument: PMC | Score: 13.42576 | Text size: 68210 | Find: similardocuments

The StanfordHTBC compound library contains ∼130,000 diverse compounds from ChemDiv (60,000), SPECS(30,000), Chembridge (23,500), ChemRX (10,000), Microsource Sepctrum,(2,320),Enzo

Novel Imidazoline Antimicrobial Scaffold That Inhibits DNA Replicationwith Activity against Mycobacteria and Drug Resistant Gram-Positive Cocci

Kendra K. Harris; Allison Fay; Han-Guang Yan; Pratima Kunwar; Nicholas D.Socci;NarenderPottabathini; Ramakrishna R.Juventhala;Hakim Djaballah; Michael S.Glickman

Originaldocument: PMC | Score: 14.301138 | Text size: 45216 | Find: similardocuments

obtainedfrom ChemBridge Research Laboratories, Biofocus, AnalytiCon Discovery, SPECS,NCI, ChemDiv, and Magellan Bioscience.

Identification of β-hematininhibitors in a high-throughput screening effort reveals scaffolds with invitro antimalarial activity

Rebecca D.Sandlin;Kim Y. Fong; Kathryn J. Wicht; Holly M. Carrell; Timothy J. Egan; David W. Wright

PMC ID: PMC4266794 | DOI: 10.1016/j.ijpddr.2014.08.002 |Journal: International Journal for Parasitology: Drugs and Drug Resistance, 4(1) pp.316-325 | Publisher: Elsevier | Publicationdate: 2014-09-11

Originaldocument: PMC | Score: 16.524874 | Text size: 44692 | Find: similardocuments

Thescreening library consisted of compounds originating from ChemBridge and ChemDiv.... in the Vanderbilt University High-Throughput Screening Facility originatedfrom ChemBridge and ChemDiv.

A broad HIV-1 inhibitor blocks envelope glycoprotein transitions criticalfor entry

Alon Herschhorn; Christopher Gu; Nicole Espy; Jonathan Richard; AndrésFinzi;Joseph G.Sodroski

Originaldocument: PMC | Score: 13.76273 | Text size: 63676 | Find: similardocuments

were fromChembridge, San Diego, CA; compounds 613 (24), 616 (27), 620 (31) and 621 (32)were fromChemDiv, San Diego, CA.

Screening-based discovery of Aspergillus fumigatus plant-type chitinaseinhibitors

Deborah E.A.Lockhart;AlexanderSchuettelkopf; David E. Blair; Daan M.F. vanAalten

Originaldocument: PMC | Score: 14.426556 | Text size: 40879 | Find: similardocuments

Compounds 1,2, 6 and 7 (ChemBridge Corporation, San Diego, CA, USA); compounds 3, 4 and 8 (ChemDiv,San Diego, CA, USA); compounds 9 and 11 (Asinex Europe, Rijswijk, NED);compound 5 (Maybridge,

High Content Image-Based Screening of a Protease Inhibitor LibraryReveals Compounds Broadly Active against Rift Valley Fever Virus and OtherHighly Pathogenic RNA Viruses

Rajini Mudhasani; Krishna P. Kota; Cary Retterer; Julie P. Tran; Chris A.Whitehouse;Sina Bavari; Anton Simeonov

Originaldocument: PMC | Score: 18.981396 | Text size: 77242 | Find: similardocuments

CompoundLibrary and Reference Reagents ChemDiv was the source of theSerine/Cysteine Protease (SCP) inhibitor library used in this study. ChemDiv builtthe library using a variety of computational programs to qualify a smallmolecule as a ... For subsequent mechanism of action studies, compounds werereordered (ChemDiv, USA) at least three different times and testedindependently to ensure consistency across batches. ... Primary Screening ofthe ChemDiv Protease Inhibitor Library The ChemDiv proteaseinhibitor library was screened against RVFV strain MP12 at 20 μM in 0.5%(v/v) DMSO. ... Screening of the ChemDiv Protease InhibitorLibrary A total of 849 compounds from ChemDiv proteaseinhibitor library were used for antiviral screening.

An Allosteric Modulator of HIV-1 Protease Shows Equipotent Inhibition ofWild-Type and Drug-Resistant Proteases

Peter M.-U. Ung; James B. Dunbar; Jason E.Gestwicki;Heather A.Carlson

Originaldocument: PMC | Score: 18.065512 | Text size: 57809 | Find: similardocuments

the querysearches against academic and commercial chemical libraries: ChemBridge(2007), ChemDiv (2007), MayBridge (2007), and the CCG(2007.10) chemical libraries. ... solubility, cost, and availability from thevendors (CCG, 5 compounds; ChemBridge, 30 compounds; ChemDiv, 8compounds; MayBridge, 5 compounds). ... and libraries of three commercialvendors: ChemBridge (EXPRESS-Pick v2007, ∼50000 compounds), ChemDiv(2007,∼120000compounds), and MayBridge (v2007, ∼56000 compounds) chemical libraries. ... Finally, 48 compounds (5 from CCG,30 from ChemBridge, 8 from ChemDiv, and 5 from MayBridge) werepurchased for experimental testing (listed in Table S1 of

Mechanisms of Neuroblastoma Cell Growth Inhibition by CARP-1 FunctionalMimetics

Magesh Muthu; Vino T. Cheriyan; Sara Munie; Edi Levi; John Frank; Abdelkader E.Ashour;Mandip Singh; Arun K. Rishi; Surinder K.Batra

PMC ID: PMC4102511 | DOI: 10.1371/journal.pone.0102567 |Journal: PLoS ONE, 9(1) | Publisher: PublicLibrary of Science | Publicationdate: 2014-07-17

Originaldocument: PMC | Score: 13.317075 | Text size: 68438 | Find: similar documents

CFM-1, -4and -5 were obtained from ChemDiv, San Diego, and Ryan Scientific,Inc., Mt.

Discovery of a Novel Compound with Anti-Venezuelan Equine EncephalitisVirus Activity That Targets the Nonstructural Protein 2

Dong-Hoon Chung; Colleen B.Jonsson;Nichole A. Tower; Yong-Kyu Chu; Ergin Sahin; Jennifer E.Golden;James W. Noah; Chad E.Schroeder;Julie B. Sotsky; Melinda I. Sosa; Daniel E. Cramer; Sara N. McKellip; Lynn Rasmussen; E. Lucile White; Connie S.Schmaljohn;Justin G.Julander;Jeffrey M. Smith; Claire MarieFilone;John H. Connor; Yasuteru Sakurai; Robert A. Davey; Timothy L.Tellinghuisen

Originaldocument: PMC | Score: 14.117049 | Text size: 50437 | Find: similardocuments

Synthesis ofquinazolinone CID15997213 CID15997213 is commercially available from ChemDiv,Inc. (CAS# 900134-28-3); however, it was synthesized at the Universityof Kansas for the purpose of

A cell-based, high-throughput homogeneous time-resolved fluorescenceassay for the screening of potential κ-opioid receptoragonists

Yue Wang; Ming Yan; Guang-yao Zheng; Ling He; Huan Yang

Originaldocument: PMC | Score: 14.2392435 | Text size: 41510 | Find: similardocuments

The testedcompounds were obtained from ChemDiv, Inc (San Diego, CA,USA).

Selective Chemical Inhibition of agr Quorum Sensing in Staphylococcusaureus Promotes Host Defense with Minimal Impact on Resistance

Erin K. Sully; NataliaMalachowa;Bradley O.Elmore;Susan M.Alexander;Jon K. Femling; Brian M. Gray; Frank R. DeLeo; Michael Otto; Ambrose L.Cheung;Bruce S. Edwards; Larry A. Sklar; Alexander R.Horswill;Pamela R. Hall; Hattie D.Gresham;Eric P. Skaar

Originaldocument: PMC | Score: 13.104898 | Text size: 80402 | Find: similardocuments

sulfonyl-1H-triazolo[1,5-a] quinazolin-5-one, CID#3243271) was synthesized by ChemDiv,confirmed purified by HPLC, and stored in DMSO at −80°C.

Beta-Catenin Regulated ALDH1A1 is a Target in Ovarian Cancer Spheroids

SalvatoreCondello;Cynthia A.Morgan;Sarbajeet Nagdas; Liyun Cao; John Turek; Thomas D. Hurley; Daniela Matei

Originaldocument: PMC | Score: 17.397476 | Text size: 60472 | Find: similardocuments

We used anovel ALDH1A1 inhibitor (A37) identified through high throughput screening ofthe ChemDiv library and the less selective inhibitor DEAB. A37has a molecular weight of 431. ... The ALDH1A1 inhibitor (A37) was from ChemDiv (SanDiego, CA, USA), having >95% purity. ... A high-throughput screen (HTS) of64,000 compounds from the ChemDiv Corp. was performed toidentify activators and inhibitors of ALDH1A1.

A novel Aβ-fibrinogeninteraction inhibitor rescues altered thrombosis and cognitive decline inAlzheimer’s disease mice

Hyung Jin Ahn; J. FraserGlickman;Ka Lai Poon; DariaZamolodchikov; Odella C.Jno-Charles;Erin H. Norris; SidneyStrickland

Originaldocument: PMC | Score: 13.648543 | Text size: 64554 | Find: similardocuments

Vendor listfor primary screening library Provider No. of compound from each provider ChemDiv 21,986Prestwick 1,110 Cerep 4,000 ChemBridge 5,000 Microsource 2,000 AMRI 50,000Biofocus

Identification of Small-Molecule Frequent Hitters from AlphaScreenHigh-Throughput Screens

Kenji Schorpp; Ina Rothenaigner; Elena Salmina; JeanetteReinshagen;Terence Low; Jara K. Brenke; JayGopalakrishnan; Igor V. Tetko; Sheraz Gul;Kamyar Hadian

Originaldocument: PMC | Score: 14.2392435 | Text size: 49966 | Find: similardocuments

library usedin the HTS campaigns was composed of compounds acquired from threeproviders—namely,ChemDiv (San Diego, CA; 10,000 compounds), EnamineLtd.

Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition ofDiverse Coronaviruses Including the Middle East Respiratory Syndrome Virus

Anna Lundin; Ronald Dijkman; TomasBergström; Nina Kann; Beata Adamiak; Charles Hannoun; Eveline Kindler; Hulda R.Jónsdóttir; Doreen Muth;Joeri Kint; Maria Forlenza; Marcel A.Müller;ChristianDrosten;Volker Thiel; Edward Trybala; Andrew Pekosz

Originaldocument: PMC | Score: 13.317075 | Text size: 80136 | Find: similar documents

Hit compoundK22 was purchased from ChemDiv (San Diego, CA; catalog number4295–0370).

Combination of 2D/3D Ligand-Based Similarity Search in Rapid VirtualScreening from Multimillion Compound Repositories. Selection and BiologicalEvaluation of Potential PDE4 and PDE5 Inhibitors

Krisztina Dobi; IstvánHajdú; BeátaFlachner;GabriellaFabó;MáriaSzaszkó; MelindaBognár; Csaba Magyar; IstvánSimon;DánielSzisz;ZsoltLőrincz; SándorCseh;GyörgyDormán

PMC ID: PMC6270928 | DOI: 10.3390/molecules19067008 |Journal: Molecules, 19(1) pp. 7008-7039 |Publisher: MDPI | Publicationdate:2014-05-28

Originaldocument: PMC | Score: 14.490094 | Text size: 53589 | Find: similardocuments

availablefrom the actual edition of the top vendor databases (~5 million compounds):ChemBridge, ChemDiv, Asinex, Enamine, IfLab, UkrOrg, AMRI, Specs,Maybridge, Interbioscreen

A Fragment-Based Method to Discover Irreversible Covalent Inhibitors ofCysteine Proteases

Stefan G.Kathman;Ziyang Xu; Alexander V.Statsyuk

Originaldocument: PMC | Score: 14.5541935 | Text size: 31413 | Find: similardocuments

fromAccelrys, 94275 commercially available carboxylic acids were identified fromthe ChemBridge, ChemDiv, MayBridge, NCI, and Sigma-Aldrichlibraries using SMARTS query strings.

DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNAdamage response

Laureen Colis; Karita Peltonen; Paul Sirajuddin; Hester Liu; Sara Sanders; Glen Ernst; James C. Barrow; Marikki Laiho

PMC ID: PMC4147329 | Journal: Oncotarget, 5(1) pp. 4361-4369 |Publisher: Impact Journals LLC | Publicationdate: 2014-05-26

Original document: PMC | Score: 14.301138 | Text size: 32671 | Find: similardocuments

N-[2(dimethylamino)ethyl]-12-oxo(BMH-21) was obtained from ChemDiv, verified for purity using LC/MSmass spectrometry and 1H-NMR.

Enrichment of Chemical Libraries Docked to Protein ConformationalEnsembles and Application to Aldehyde Dehydrogenase 2

Bo Wang; Cameron D.Buchman;Liwei Li; Thomas D. Hurley; Samy O. Meroueh

Originaldocument: PMC | Score: 17.614815 | Text size: 56294 | Find: similardocuments

The negativeset consisted of 5000 randomly selected compounds from the ChemDiv librarydocked to a pocket within the target of interest. ... The 5000 randomly pickedcompounds from ChemDiv library docked to ALDH2 crystalstructure were used as the negative set to build the SVMSP model. ... A focusedset of theChemDiv commercial library64 containing 50 000 compoundswere docked to each of the 50 snapshots by

A kinetic fluorescence assay reveals unusual features of Ca++ uptake inPlasmodium falciparum-infected erythrocytes

Elizabeth MZipprer;McKinzie Neggers; Ambuj Kushwaha; KempaiahRayavara;Sanjay A Desai

PMC ID: PMC4078004 | DOI: 10.1186/1475-2875-13-184 |Journal: Malaria Journal, 13(1) pp. 184-184 |Publisher: BioMed Central |Publication date: 2014-05-18

Originaldocument: PMC | Score: 14.2392435 | Text size: 40362 | Find: similardocuments

exception ofthe specific PSAC inhibitor ISPA-28 (a dihydroisoxazole-5-carboxamidederivative from ChemDiv, San Diego, CA, USA).

The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 duringfission yeast cytokinesis

Ning Wang; Libera Lo Presti; Yi-Hua Zhu; Minhee Kang; Zhengrong Wu; Sophie G. Martin; Jian-Qiu Wu

Originaldocument: PMC | Score: 13.878843 | Text size: 86332 | Find: similardocuments

The Arp2/3inhibitor CK666 (ChemDiv; Nolen et al.

Potential Novel Antibiotics from HTS Targeting the Virulence-regulatingTranscription Factor, VirF, from Shigella flexneri

Anthony A.Emanuele;Nancy E. Adams; Yi-Chen Chen; Anthony T.Maurelli;George A. Garcia

Originaldocument: PMC | Score: 19.076883 | Text size: 42995 | Find: similardocuments

Compoundsselected for reconfirmation screening were purchased from ChemDiv (7compounds, San Diego, CA) and Vitas-M Laboratory (3 compounds, Moscow, Russia).... Small Molecule Library A 100,000 compound library produced by ChemDiv (SanDiego, CA) was screened at the Center for Chemical Genomics (CCG, University ofMichigan Ann ... Non-cytotoxic Conc. (μM)3Bacterial GrowthInhibition4 19615 Vitas-M 14 6.25 2% @ 100 μM 144092 ChemDiv 236.25 13% @ 100 μM144143 ChemDiv 23 6.25 14% @ 100 μM 153578ChemDiv 3712.5 19% @ 100 μM24904 ChemDiv 66 50 13% @ 50 μM 1Compounds 25354, 3776,25073, 16977 and 21496 did not reconfirm and were not

Identification of Novel Serotonin Transporter Compounds by VirtualScreening

Mari Gabrielsen; RafałKurczab;Agata Siwek; MałgorzataWolak;Aina W. Ravna; Kurt Kristiansen; Irina Kufareva; Ruben Abagyan; Gabriel Nowak;ZdzisławChilmonczyk;Ingebrigt Sylte; Andrzej J.Bojarski

Originaldocument: PMC | Score: 16.735006 | Text size: 51913 | Find: similardocuments

and buildingblock collections of five commercial databases were screened: Asinex,40ChemBridge,41ChemDiv,42 Enamine,43 and Life Chemicals. ... first step ofthe VS protocol, screening of the druglike subsets of the Asinex,40ChemBridge,41 ChemDiv,42 Enamine,43 and Life Chemicals44 databasesusing 2D pharmacophore-based fingerprints and

Design, Synthesis, and Structure–Activity Relationship of a Novel Seriesof GluN2C-Selective Potentiators

Sommer S. Zimmerman; Alpa Khatri; Ethel C. Garnier-Amblard; PraseedaMullasseril;Natalie L.Kurtkaya;Stefka Gyoneva; Kasper B. Hansen;Stephen F.Traynelis;Dennis C. Liotta

Originaldocument: PMC | Score: 12.899377 | Text size: 127425 | Find: similardocuments

Receptors Afluorescence-based screen of 57504 compounds obtained from Asinex and ChemDiv librarieswas performed in BHK cells with inducible expression of GluN1/GluN2C receptors.

Development of Selective Inhibitors for Aldehyde Dehydrogenases Based onSubstituted Indole-2,3-diones

Ann C.Kimble-Hill;Bibek Parajuli; Che-Hong Chen; DariaMochly-Rosen; Thomas D. Hurley

Originaldocument: PMC | Score: 17.583435 | Text size: 45337 | Find: similardocuments

this groupof compounds further, we obtained an additional 33 structurally similaranalogues from ChemDivand ChemBridge and evaluated their ability toinhibit ALDH1A1, ALDH2, and ALDH3A1 using ... The following compounds werepurchased from ChemDiv for further screening: 0764-0625,1-pentyl-2,3-dihydro-1H-indole-2,3-dione (compound 2); ... Inhibitors thatemerged from the screens were purchased from ChemBridge orChemDiv.

In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors

Yaxue Zhao; Qingqing Meng; Linquan Bai; Huchen Zhou

PMC ID: PMC3907873 | DOI: 10.3390/ijms15011358 |Journal: International Journal of Molecular Sciences, 15(1) pp.1358-1373 | Publisher:Molecular Diversity Preservation International(MDPI) |Publicationdate: 2014-01-20

Originaldocument: PMC | Score: 14.618862 | Text size: 35215 | Find: similardocuments

When thispharmacophore was used to search the ChemDiv diversecollection database [53], thirty-one compounds were identified.

Identification of Clinically Viable Quinolinol Inhibitors of BotulinumNeurotoxin A Light Chain

DejanCaglič;Michelle C.Krutein;Kristin M. Bompiani; Deborah J.Barlow;Galit Benoni; Jeffrey C.Pelletier;Allen B. Reitz; Luke L. Lairson; Karen L.Houseknecht;Garry R. Smith; Tobin J.Dickerson

Originaldocument: PMC | Score: 16.60829 | Text size: 39082 | Find: similardocuments

A range ofquinolinol compounds are commercially available from ChemDiv andChemBridge small molecule repositories and were included into a screening setbased on the ... Purity of ChemDiv compounds was confirmed bythe supplier by LC/MS and NMR and had a purity of >95%.

In Vitro Evaluation of Novel Inhibitors against the NS2B-NS3 Protease ofDengue Fever Virus Type 4

Thi Thanh HanhNguyen;Sun Lee; Hsi-Kai Wang; Hsin-Yen Chen; Ying-Ta Wu; Simon C. Lin; Do-Won Kim; Doman Kim

PMC ID: PMC6269914 | DOI: 10.3390/molecules181215600 |Journal: Molecules, 18(1) pp. 15600-15612 |Publisher: MDPI | Publicationdate: 2013-12-13

Originaldocument: PMC | Score: 16.863674 | Text size: 31340 | Find: similardocuments

The NS3prodocking library comprised 300,000 compounds from ChemDiv Inc. (SanDiego, CA, USA), a commercially available compound library, was used for VS.... Sample Availability: All tested compounds are commercially availablefrom ChemDiv Inc. (San Diego, CA, USA).

PITPs as Targets for Selectively Interfering With PhosphoinositideSignaling in Cells

Aaron H. Nile; AshutoshTripathi;Peihua Yuan; Carl J. Mousley; Sundari Suresh; Iain MichaelWallace;Sweety D. Shah; Denise TeoticoPohlhaus;Brenda Temple; Corey Nislow; Guri Giaever; AlexanderTropsha;Ronald W. Davis; Robert P. StOnge;Vytas A.Bankaitis

Originaldocument: PMC | Score: 13.878843 | Text size: 72104 | Find: similardocuments

Smallmolecule inhibitors The compounds shown in Supplementary Figure 1 werefrom ChemDiv (San Diego, CA).

Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1Nef function using a yeast-based phenotypic screen

Ronald P Trible; PurushottamNarute;Lori AEmert-Sedlak; John JeffAlvarado;Katelyn Atkins; Laurel Thomas; Toshiaki Kodama; Naveena Yanamala;VasiliyKorotchenko;Billy W Day; Gary Thomas; Thomas ESmithgall

PMC ID: PMC3874621 | DOI: 10.1186/1742-4690-10-135 |Journal: Retrovirology, 10(1) pp. 135-135 |Publisher: BioMed Central |Publication date: 2013-11-14

Originaldocument: PMC | Score: 17.869274 | Text size: 72190 | Find: similardocuments

μl) wereplated in duplicate wells of a 96-well plate in the presence of each compoundfrom the ChemDivkinase-biased inhibitor library (ChemDiv, Inc.,San Diego, CA). All compounds were initially screened at 10 μM with 0.5%DMSO as carrier solvent. ... observed with A-419259 were obtained in powderform from the provider of the original library (ChemDiv) and assayed athird time in triplicate at 1, 3, 10, and 30 μM in comparison with 5 μM A-419259.... The test compounds DQBS, 2,3-diaminoquinoxaline (ChemDiv) anddasatinib (LC Laboratories) were solubilized in DMSO and diluted into the DSFassays, followed

Turning Defense into Offense: Defensin Mimetics as Novel AntibioticsTargeting Lipid II

Kristen M.Varney;Alexandre M. J.J. Bonvin;Marzena Pazgier; Jakob Malin; Wenbo Yu; Eugene Ateh; Taiji Oashi; Wuyuan Lu; Jing Huang; MarliesDiepeveen-de Buin; Joseph Bryant; Eefjan Breukink; Alexander D.MacKerell;Erik P. H. deLeeuw;Michael Zasloff

Originaldocument: PMC | Score: 13.76273 | Text size: 68381 | Find: similardocuments

databases;Maybridge (Thermo Fisher Scientific Inc., Wattham, MA), ChemBridge (San Diego,CA), and ChemDiv(San Diego, CA), which contain 59676, 482276, and533143 compounds, respectively.

Wnt signaling blockage inhibits cell proliferation and migration, andinduces apoptosis in triple-negative breast cancer cells

Birdal Bilir; Omer Kucuk; Carlos S Moreno

PMC ID: PMC4228255 | DOI: 10.1186/1479-5876-11-280 |Journal: Journal of Translational Medicine, 11(1) pp. 280-280 |Publisher: BioMed Central | Publicationdate: 2013-11-04

Originaldocument: PMC | Score: 13.878843 | Text size: 47742 | Find: similardocuments

Louis, MO).iCRT-3, iCRT-5 and iCRT-14 were obtained from ChemDiv (SanDiego, CA). IWP-4 was purchased from Stemgent (San Diego, CA).

Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growththrough Innate Immunity

MarianneLucas-Hourani; Daniel Dauzonne; Pierre Jorda; GaëlleCousin;Alexandru Lupan; Olivier Helynck; GrégoryCaignard;GenevièveJanvier;GwénaëlleAndré-Leroux; Samira Khiar; Nicolas Escriou; PhilippeDesprès; Yves Jacob; HélèneMunier-Lehmann; FrédéricTangy;Pierre-OlivierVidalain;Ganes C. Sen

Originaldocument: PMC | Score: 15.963614 | Text size: 82706 | Find: similardocuments

librariesacquired through Prestwick Chemical (1,120 compounds;www.prestwickchemical.com) andChemDiv (eu.chemdiv. ... Compoundsfrom Prestwick Chemical and ChemDiv were at 2 mg/ml, whichcorresponds to 6.32±2.8 mM (Prestwick Chemical), 5.57±0.89 (CDI) and 5.35±1.

AutomiG, a Biosensor to Detect Alterations in miRNA Biogenesis and inSmall RNA Silencing Guided by Perfect Target Complementarity

ClémentCarré; CarolineJacquier;Anne-LaureBougé; Fabrice deChaumont;CorinneBesnard-Guerin; HélèneThomassin;Josette Pidoux; Bruno Da Silva; EleftheriaChalatsi;Sarah Zahra; Jean-ChristopheOlivo-Marin;HélèneMunier-Lehmann; ChristopheAntoniewski;HelenWhite-Cooper

PMC ID: PMC3760873 | DOI: 10.1371/journal.pone.0074296 |Journal: PLoS ONE, 8(1) | Publisher: PublicLibrary of Science | Publicationdate: 2013-09-03

Originaldocument: PMC | Score: 13.996932 | Text size: 54936 | Find: similardocuments

and 9360compounds (ATP-mimic library) and 4624 compounds (nucleoside-like library)from ChemDiv Inc(http://eu.chemdiv.com/).

Small molecule Plasmodium FKBP35 inhibitor as a potential antimalariaagent

AmaravadhiHarikishore;Makhtar Niang; Sreekanth Rajan; Peter RainerPreiser;Ho Sup Yoon

PMC ID: PMC3752609 | DOI: 10.1038/srep02501 |Journal: Scientific Reports, 3(1) | Publisher: NaturePublishing Group | Publicationdate:2013-08-26

Originaldocument: PMC | Score: 16.692554 | Text size: 46063 | Find: similardocuments

Uponscreening our in-house ADME property filtered 3D virtual database of ChemDiv commerciallibrary with this five feature structure based pharmacophore model (Fig. ...Pharmacophore screening on ChemDiv library resulted in afocused library of 13,000 molecules.

Inhibition of the Growth Factor MDK/Midkine by a Novel Small MoleculeCompound to Treat Non-Small Cell Lung Cancer

Huifang Hao; Yutaka Maeda; Takuya Fukazawa; Tomoki Yamatsuji; Munenori Takaoka; Xiao-Hong Bao; Junji Matsuoka; Tatsuo Okui; Tsuyoshi Shimo;Nagio Takigawa; Yasuko Tomono; Motowo Nakajima; Iris M.Fink-Baldauf; Sandra Nelson; William Seibel; Ruben Papoian; Jeffrey A.Whitsett;Yoshio Naomoto; Masaru Katoh

PMC ID: PMC3745462 | DOI: 10.1371/journal.pone.0071093 |Journal: PLoS ONE, 8(1) | Publisher: PublicLibrary of Science | Publicationdate: 2013-08-16

Original document: PMC | Score: 13.996932 | Text size: 40424 | Find: similardocuments

[2,1-beta][1],[3]thiazol-6-yl]-2H-chromen-2-one (hereafter iMDK) purchased from ChemDiv (SanDiego, CA) was dissolved in DMSO.

A Yeast-Based Chemical Screen Identifies a PDE Inhibitor That ElevatesSteroidogenesis in Mouse Leydig Cells via PDE8 and PDE4 Inhibition

Didem Demirbas; Arlene R. Wyman; MasamiShimizu-Albergine; Ozgur Cakici; Joseph A. Beavo; Charles S.Hoffman;Gordon Chua

PMC ID: PMC3743849 | DOI: 10.1371/journal.pone.0071279 |Journal: PLoS ONE, 8(1) | Publisher: PublicLibrary of Science | Publicationdate: 2013-08-14

Originaldocument: PMC | Score: 18.948826 | Text size: 43543 | Find: similardocuments

leu1-32cgs2-2 pap1Δars1::pNMT1-PDE8Acat Small Molecules Small molecules were purchased fromChemDiv (SanDiego, CA; BC8-15: E973-0331, BC8-15A: E881-0067, BC8-15C: C301-5319). ...School ICCB Screening facility (Asinex 1, Biomol-TimTec1, Bionet 1, Bionet 2,CEREP, ChemBridge 3, ChemDiv 1, ChemDiv2, ChemDiv 3, ChemDiv 4, ChemDiv 6,Enamine 1, Enamine 2, I.F. Lab 2, Life Chemicals 1, MayBridge 1, MayBridge 2,MayBridge 3, ... of the 63 strong hits that produced OD values of >0.6 camefrom only six libraries (ChemBridge 3, ChemDiv 3, ChemDiv 4,Enamine 1, Enamine 2, and MayBridge 3) that represented 37% of the screenedcompounds.

Small-Molecule Inhibitors of toxT Expression in Vibrio cholerae

RebeccaAnthouard;Victor J. DiRita

PMC ID: PMC3735192 | DOI: 10.1128/mBio.00403-13 |Journal: mBio, 4(1) | Publisher: AmericanSociety of Microbiology | Publicationdate:2013-08-06

Originaldocument: PMC | Score: 16.524874 | Text size: 50364 | Find: similardocuments

pyrazol-6-one]were obtained from ChemDiv (San Diego, CA). ... displayeddose-dependent activity, the 50 most potent (a low GFP/OD600 value) wereordered from ChemDiv and similarly retested for effects ongrowth and toxT transcription and for effects on CT

Inhibition of Histo-blood Group Antigen Binding as a Novel Strategy toBlock Norovirus Infections

Xu-Fu Zhang; Ming Tan; Monica Chhabra; Ying-Chun Dai; Jarek Meller; Xi Jiang; Eugene A.Permyakov

PMC ID: PMC3716607 | DOI: 10.1371/journal.pone.0069379 |Journal: PLoS ONE, 8(1) | Publisher: PublicLibrary of Science | Publicationdate: 2013-07-19

Originaldocument: PMC | Score: 14.490094 | Text size: 37822 | Find: similardocuments

(http://www.molport.com) supplied by Maybridg, TimTec, ChemBridge, Pharmeks, Specs, Otava, ChemDiv,InterBioScreen Ltd, Vitas-M Laboratory, Princeton Biomolecular Research andEnamine Ltd.

Structure-based discovery of fiber-binding compounds that reduce thecytotoxicity of amyloid beta

Lin Jiang; Cong Liu; David Leibly; Meytal Landau; Minglei Zhao; Michael P Hughes; David SEisenberg;John Kuriyan

PMC ID: PMC3713518 | DOI: 10.7554/eLife.00857 |Journal: eLife, 2(1) | Publisher: eLifeSciences Publications, Ltd | Publicationdate: 2013-07-16

Originaldocument: PMC | Score: 17.724873 | Text size: 88775 | Find: similardocuments

5 ± 8ZINC28616347 BAF17 C23H25N5O2 404 Sigma-Aldrich 6 ± 3 ZINC00579168 BAF18C24H16O2 336ChemDiv 6 ± 2 ZINC02168932 BAF19 C18H14N2O6 354 ChemDiv 3± 4 ZINC01507439 BAF20 C25H19N5OS 438 ChemDiv 8 ± 4ZINC15859747 BAF21 C19H14Br2O 418 ChemDiv 6 ± 3 ZINC38206526BAF22 C21H16N2O3S2 408 Life Chemicals 3 ± 5 ZINC04496365 BAF23 C16H11ClO5S 351

Development of Dimethyl Sulfoxide Solubility Models Using 163 000Molecules: Using a Domain Applicability Metric to Select More ReliablePredictions

Igor V. Tetko; SergiiNovotarskyi;Iurii Sushko; Vladimir Ivanov; Alexander E.Petrenko;Reiner Dieden; Florence Lebon; Benoit Mathieu

Originaldocument: PMC | Score: 14.5541935 | Text size: 58439 | Find: similardocuments

A previousestimation of inconsistencies in DMSO solubility measurements has been reportedby the ChemDivcompany: a random re-evaluation of their datarevealed a 1% error rate.

Targeting Fatty Acid Binding Protein (FABP) Anandamide Transporters – ANovel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs

William T.Berger;Brian P. Ralph; Martin Kaczocha; Jing Sun; Trent E. Balius; Robert C. Rizzo; SamirHaj-Dahmane;Iwao Ojima; Dale G. Deutsch;AlbericoCatapano

PMC ID: PMC3517626 | DOI: 10.1371/journal.pone.0050968 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-12-07

Originaldocument: PMC | Score: 19.39129 | Text size: 49852 | Find: similardocuments

The mostpotent inhibitor, γ-truxillicacid 1-naphthyl ester (ChemDiv 8009-2334), was determined to haveKi value of 1.19±0.01 μM. ...include: (1) Screen approximately one million compounds using a subset of theZINC [12] database (ChemDiv. ... the 48 compounds tested, 23 showed atleast 25% inhibition and 4 compounds, having the following ChemDiv ID(Stony Brook ID) numbers 5511-0235 (SB-FI-19), 8009-2334 (SB-FI-26 orSB-FI-49), 8009-7646 ... Overall, four compounds from the ChemDiv compoundlibrary were identified as potential competitive inhibitors of FABP5. The mostpotent compound, ChemDiv 8009-2334, was found to possess adiphenyl-cyclobutane core characteristic of the known natural

A phenotypic screening platform to identify small molecule modulators ofChlamydomonas reinhardtii growth, motility and photosynthesis

Simon E Alfred; AnuradhaSurendra;Chris Le; Ken Lin; Alexander Mok; Iain M Wallace; Michael Proctor; Malene L Urbanus; Guri Giaever; Corey Nislow

Originaldocument: PMC | Score: 16.60829 | Text size: 52782 | Find: similardocuments

that wecollated based on yeast growth inhibition from ChemBridge (NOVACore and DIVERSet)and ChemDiv(Divers) collections [38] (Table S2 in Additional file2). ... yeast actives set derived from ChemBridge (NOVACore and DIVERSet, SanDiego, CA, USA) and ChemDiv (Divers, San Diego, CA, USA), andtwo stock plates from ChemBridge (NOVACore, San Diego, CA, USA).

Identification of Small Molecules That Suppress Ricin-InducedStress-Activated Signaling Pathways

Paul G. Wahome; Sarita Ahlawat; Nicholas J.Mantis;Ludger Johannes

PMC ID: PMC3486792 | DOI: 10.1371/journal.pone.0049075 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-11-01

Originaldocument: PMC | Score: 18.140217 | Text size: 41649 | Find: similardocuments

pure compoundsfrom the commercially available chemical libraries (Actimol TimTec,Bionet, ChemDiv, CEREP, Enamine, I.F. Lab, Maybridge, and Peakdale)was performed at the National Screening ... cell-based assay at the NSRB toscreen more than 118,000 compounds in the Actimol TimTec, Bionet, ChemDiv,CEREP, Enamine, I. F. Lab, Maybridge, and Peakdale libraries for inhibitors ofricin toxin [16]. ... 9 PW69 6-oxo-N-(1-phenylbutan-2-yl)-5H-benzo[b][1], [4]benzothiazepine-3-carboxamide 6623219b ChemDiv 23 PW69B 6-oxo-N-(4-phenylbutan-2-yl)-5H-benzo[b][1],[4] benzothiazepine-3-carboxamide 20885127b ChemDiv 22 PW721-[3-(furan-2-yl)-7-(furan-2-ylmethylidene)-3a,4,

Structure and Activity Analysis of Inauhzin Analogs as Novel AntitumorCompounds That Induce p53 and Inhibit Cell Growth

Qi Zhang; Derong Ding; Shelya X. Zeng; Qi-Zhuang Ye; Hua Lu; Hirofumi Arakawa

PMC ID: PMC3480348 | DOI: 10.1371/journal.pone.0046294 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-10-24

Originaldocument: PMC | Score: 13.996932 | Text size: 50141 | Find: similardocuments

Materialsand Methods Compounds S1–S34 INZ analogs S1–S34 were purchased fromAsinex, ChemDiv and ChemBridge.

Identification of Fungicidal 2,6-Disubstituted Quinolines with Activityagainst Candida Biofilms

Nicolas Delattin; DorothéeBardiot;Arnaud Marchand; Patrick Chaltin; Katrijn DeBrucker;Bruno P. A.Cammue;Karin Thevissen

PMC ID: PMC6268363 | DOI: 10.3390/molecules171012243 |Journal: Molecules, 17(1) pp. 12243-12251 |Publisher: MDPI | Publicationdate: 2012-10-18

Originaldocument: PMC | Score: 14.684109 | Text size: 21705 | Find: similardocuments

(18) werepurchased from ChemDiv (San Diego, CA, USA). Synthesis of theamide derivatives has been described previously [14].

Anti-Cancer Activity of a Novel Small Molecule Compound ThatSimultaneously Activates p53 and Inhibits NF-κB Signaling

Sun Gwan Hwang; Jinah Park; Joo Young Park; Cheol HyoungPark;Ki-Ho Lee; Jeong Woo Cho; Jong-Ik Hwang; Jae Young Seong; Aamir Ahmad

PMC ID: PMC3441512 | DOI: 10.1371/journal.pone.0044259 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-09-13

Originaldocument: PMC | Score: 13.878843 | Text size: 49359 | Find: similardocuments

compoundlibrary consisted of 200,000 chemicals provided by the ChemBridge (San Diego,CA, USA),ChemDiv (San Diego, CA, USA), and Asinex (Moscow, Russia)chemical libraries.

Mining collections of compounds with Screening Assistant 2

Vincent LeGuilloux;Alban Arrault; LionelColliandre;StéphaneBourg;Philippe Vayer; Luc Morin-Allory

PMC ID: PMC3547782 | DOI: 10.1186/1758-2946-4-20 |Journal: Journal of Cheminformatics, 4(1) pp. 20-20 |Publisher: BioMed Central |Publication date: 2012-08-31

Originaldocument: PMC | Score: 14.74994 | Text size: 65469 | Find: similardocuments

ChemDiv (CU=54.97%,SU=45.23% and FU=31.49%).

ToxAlerts: A Web Server of Structural Alerts for Toxic Chemicals andCompounds with Potential Adverse Reactions

Iurii Sushko; Elena Salmina; Vladimir A.Potemkin;Gennadiy Poda; Igor V. Tetko

Originaldocument: PMC | Score: 18.995876 | Text size: 34364 | Find: similardocuments

ToxAlertsplatform, we virtually screened screening libraries from three providers ofchemicals: ChemDiv ( www.chemdiv.com), LifeChemicals (www.lifechemicals.com), and Enamine ( www.enamine. ... by the company and builtaround 2181 original templates.21 The largest compound library was from ChemDiv andcontained almost 400 000 chemical structures available in stock from thiscompany. ... and Set of Structural Alerts from Three Different Providersprovideralertsscreening compounds ChemDiv alerts 100 391145Life Chemicals alerts 72 343949 Enamine alerts 108 228899 Screening Results The... Results for Three Compound Libraries and DrugBank against Three Sets ofStructural Alertsa ChemDiv compounds Life Chemicals compoundsEnamine compounds DrugBank compounds alerts settotal

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51

Shamila S.Gunatilleke;Claudia M.Calvet;Jonathan B.Johnston;Chiung-KuangChen;Grigori Erenburg; Jiri Gut; Juan C. Engel; Kenny K. H. Ang;Joseph Mulvaney; Steven Chen; Michelle R.Arkin;James H.McKerrow;Larissa M.Podust;Michael P.Pollastri

Originaldocument: PMC | Score: 16.279572 | Text size: 67554 | Find: similardocuments

consistingof 103,986 diverse small molecules purchased from ChemBridge (San Diego,California), ChemDiv(San Diego, California) and SPECS (Delft,Netherlands) was screened against recombinant T. cruzi ...{α-[(4-methylcyclohexyl)carbonylamino]-N-4-pyridinyl-1H-indole-3-propanamide}purchased from ChemDiv (#C155-0123) (San Diego, California), referenced previously as LP-10 [14], [23],[26], was used as

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1and IKKε

Jessica E. Hutti; Melissa A.Porter;Adam W. Cheely; Lewis C. Cantley; Xiaodong Wang; Dmitri Kireev; Albert S.Baldwin;William P.Janzen;Edward Harhaj

PMC ID: PMC3408500 | DOI: 10.1371/journal.pone.0041494 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-07-30

Original document: PMC | Score: 14.618862 | Text size: 34916 | Find: similardocuments

than 100Kcompounds were initially reviewed in the form of SD files from LifeChemicals, ChemDiv, Asinex and Enamine.

Antidiarrheal efficacy of a quinazolin CFTR inhibitor on human intestinalepithelial cell and in mouse model of cholera

JenvitPatanayindee; ChatchaiMuanprasat;SunhapasSoodvilai;VaranujChatsudthipong

Originaldocument: PMC | Score: 14.5541935 | Text size: 22203 | Find: similardocuments

(UT, USA);carbachol, amiloride, and amphotericin B from Sigma-Aldrich (MO, USA); and DQAfrom ChemDiv(CA, USA).

Characterization of Plasmodium falciparum Adenylyl Cyclase-β and Its Role in Erythrocytic Stage Parasites

Eric Salazar; Erin M. Bank; Nicole Ramsey; Kenneth C. Hess; Kirk W. Deitsch; Lonny R. Levin; Jochen Buck; Stuart AlexanderRalph

PMC ID: PMC3383692 | DOI: 10.1371/journal.pone.0039769 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-06-26

Originaldocument: PMC | Score: 14.301138 | Text size: 42743 | Find: similardocuments

of WeillMedical College of Cornell University, and other KH7-like compounds werepurchased from ChemDiv(San Diego, CA).

Arp2/3 complex–dependent actin networks constrain myosin II function indriving retrograde actin flow

Qing Yang; Xiao-Feng Zhang; Thomas D.Pollard;Paul Forscher

Originaldocument: PMC | Score: 13.42576 | Text size: 75678 | Find: similardocuments

CK666 waspurchased from ChemDiv, Inc. CK689, CK869, CK312,blebbistatin, and Y27632 were purchased from EMD.

A Novel Small Molecule Inhibitor of Influenza A Viruses that TargetsPolymerase Function and Indirectly Induces Interferon

Mila BrumOrtigoza;Oliver Dibben; Jad Maamary; LuisMartinez-Gil; Victor H.Leyva-Grado;Pablo Abreu; Juan Ayllon; Peter Palese; Megan L. Shaw;Kanta Subbarao

Originaldocument: PMC | Score: 18.045282 | Text size: 83571 | Find: similardocuments

Scientific,Mount Pleasant, SC), Chembridge 3 (10,560 compounds; ChemBridge Corp., SanDiego, CA),ChemDiv 2 (8,560 compounds; ChemDiv, Inc.,San Diego, CA), ChemDiv 4 (1,320 compounds; ChemDiv,Inc., San Diego, CA), Enamine 2 (26,576 compounds; ENAMINE Ltd. ...compounds; Maybridge Ltd., Trevillett, England), Mixed Commercial Plate 5 (268compounds from ChemDiv and Maybridge libraries), Peakdale 2(352 compounds; Peakdale Molecular Ltd.

IspE Inhibitors Identified by a Combination of In Silico and In VitroHigh-Throughput Screening

NaomiTidten-Luksch; RaffaellaGrimaldi;Leah S. Torrie; Julie A.Frearson;William N.Hunter;Ruth Brenk; RamónCampos-Olivas

PMC ID: PMC3340893 | DOI: 10.1371/journal.pone.0035792 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-04-25

Originaldocument: PMC | Score: 13.878843 | Text size: 66500 | Find: similardocuments

was ordered fromMaybridge (Fisher Scientific UK Ltd, Leicestershire, UK), compounds 2 and 3from ChemDiv(San Diego, USA), compounds 4, 7, 9, 11, 12, 13 fromEnamine Ltd.

The EYA Tyrosine Phosphatase Activity Is Pro-Angiogenic and Is Inhibitedby Benzbromarone

EmmanuelTadjuidje;Tim Sen Wang; Ram NareshPandey;Saulius Sumanas; Richard A. Lang; Rashmi S. Hegde; Justin Kumar

PMC ID: PMC3335822 | DOI: 10.1371/journal.pone.0034806 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-04-24

Original document: PMC | Score: 13.878843 | Text size: 54067 | Find: similardocuments

L129305) andcompounds 1b–1j from ChemDiv (cat. nos.

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumourgrowth through activation of p53

Qi Zhang; Shelya X Zeng; Yu Zhang; Yiwei Zhang; Derong Ding; Qizhuang Ye; Samy O Meroueh; Hua Lu

Originaldocument: PMC | Score: 15.963614 | Text size: 72194 | Find: similardocuments

our initialcomputational screening of half a million of commercially available compoundsfrom the ChemDivchemical library, we selected and purchased 50 topcandidates. ... compounds for the cell-based screen, INZ and its analogues werepurchased from Asinex, ChemDiv and ChemBridge.

Identification of Novel Mt-Guab2 Inhibitor Series Active against M.tuberculosis

VeeraraghavanUsha;Judith V.Hobrath;Sudagar S.Gurcha;Robert C.Reynolds;Gurdyal S. Besra; Anil Kumar Tyagi

PMC ID: PMC3315515 | DOI: 10.1371/journal.pone.0033886 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-03-29

Originaldocument: PMC | Score: 18.756086 | Text size: 61499 | Find: similar documents

hits listedin Figure S3 that are available from Life Chemicals and a single compoundfrom ChemDiv. ... was purchased from the commercial vendorsChembridge (Chembridge set), Life Chemicals and ChemDiv (LifeChemicals set) and were used as supplied from the vendors without furthercharacterization or ... Life Chemicals compound set, consisting of seventeencompounds from Life Chemicals and one from ChemDiv. ... (UC) 71.3(UC) 6.70 >5.97 3 F2536-1573 79.0 (UC) 55.0 (UC) 1.02 6.68 >128 Compound1499-0691 fromChemDiv is also included in this set. ... Of theeighteen hits from the Life Chemicals and ChemDiv compoundset, seven compounds exhibited antimycobacterial activity against M. smegmatis,four of

A Chemical Screen Probing the Relationship between Mitochondrial Contentand Cell Size

Toshimori Kitami; David J. Logan; Joseph Negri; Thomas Hasaka; Nicola J.Tolliday;Anne E.Carpenter;Bruce M.Spiegelman;Vamsi K. Mootha;Yidong Bai

PMC ID: PMC3315575 | DOI: 10.1371/journal.pone.0033755 |Journal: PLoS ONE, 7(1) | Publisher: PublicLibrary of Science | Publicationdate: 2012-03-29

Original document: PMC | Score: 14.618862 | Text size: 31623 | Find: similardocuments

Commercial compounds:3520 drug-like libraries from TimTec, Maybridge, and ChemDiv.

Structure-Based Virtual Screening for Drug Discovery: a Problem-CentricReview

Tiejun Cheng; Qingliang Li; Zhigang Zhou; Yanli Wang; Stephen H.Bryant

PMC ID: PMC3282008 | DOI: 10.1208/s12248-012-9322-0 |Journal: The AAPS Journal, 14(1) pp. 133-141 |Publisher: Springer US |Publication date: 2012-01-27

Originaldocument: PMC | Score: 14.684109 | Text size: 51086 | Find: similardocuments

56,000http://www.maybridge.com WOMBAT Commercial 263,000http://www.sunsetmolecular.com ChemDivCommercial 1.5 millionhttp://www.chemdiv.com ChemNavigator Commercial 55.3 million http://www.

Defective CFTR-Dependent CREB Activation Results in ImpairedSpermatogenesis and Azoospermia

Wen Ming Xu; Jing Chen; Hui Chen; Rui Ying Diao; Kin Lam Fok; Jian Da Dong; Ting Ting Sun; Wen Ying Chen; Mei Kuen Yu; Xiao Hu Zhang; Lai Ling Tsang; Ann Lau; Qi Xian Shi; Qing Hua Shi; Ping Bo Huang; Hsiao Chang Chan; Irina Agoulnik

PMC ID: PMC3090391 | DOI: 10.1371/journal.pone.0019120 |Journal: PLoS ONE, 6(1) | Publisher: PublicLibrary of Science | Publication date: 2011-05-09

Originaldocument: PMC | Score: 14.117049 | Text size: 61054 | Find: similar documents

In someexperiment groups, 10 μM CFTRinh172(Sigma), 10 μM KH7 (ChemDiv),50 ng recombinant FSH were added to the media.

Anticancer activity of the iron facilitator LS081

Zhen Li; Hiroki Tanaka; Floyd Galiano; Jonathan Glass

Originaldocument: PMC | Score: 16.44229 | Text size: 43845 | Find: similardocuments

The chemicallibraries were obtained from ChemDiv (San Diego, CA) andTimTec (Newark, DE). ... In the initial screening of the compounds obtained from ChemDiv thirtycompounds exhibited negative values for Δ Fn, i.e. Δ Fn <-50% and were therefore defined as

Identification of Human IKK-2 Inhibitors of Natural Origin (Part I):Modeling of the IKK-2 Kinase Domain, Virtual Screening and Activity Assays

Esther Sala; Laura Guasch; JustynaIwaszkiewicz; Miquel Mulero; Maria-JosepaSalvadó; MontserratPinent;Vincent Zoete; AurélienGrosdidier;SantiagoGarcia-Vallvé; OlivierMichielin;Gerard Pujadas; Vladimir Uversky

PMC ID: PMC3044726 | DOI: 10.1371/journal.pone.0016903 |Journal: PLoS ONE, 6(1) | Publisher: PublicLibrary of Science | Publicationdate: 2011-02-24

Originaldocument: PMC | Score: 14.363574 | Text size: 71781 | Find: similardocuments

this sense,the results of the present study outperform those of a recent in silico surveyon the ChemDivdatabase (http://us.chemdiv.

Essential Metabolites of Mycobacterium tuberculosis and Their Mimics

Gyanu Lamichhane; Joel S.Freundlich;Sean Ekins; NilukaWickramaratne; Scott T. Nolan; William R.Bishai

PMC ID: PMC3031304 | DOI: 10.1128/mBio.00301-10 |Journal: mBio, 2(1) | Publisher: AmericanSociety of Microbiology | Publicationdate:2011-02-01

Originaldocument: PMC | Score: 14.2392435 | Text size: 56556 | Find: similardocuments

50 Bleomycin57 MIC=0.1 μg/ml CDDdatabase Hydroxymethylbilane ChemDiv 4286-0015d 45 IC50=3.38μMc CDDdatabase Porfimer 45 CDD database a Examples of biomolecules

Modular Chemical Descriptor Language (MCDL): Stereochemical modules

Andrei A Gakh; Michael NBurnett;Sergei VTrepalin;Alexander VYarkov

PMC ID: PMC3042968 | DOI: 10.1186/1758-2946-3-5 |Journal: Journal of Cheminformatics, 3(1) pp. 5-5 |Publisher: BioMed Central |Publication date: 2011-01-31

Originaldocument: PMC | Score: 14.783076 | Text size: 43276 | Find: similardocuments

Thefollowing differences were found in non-stereo testing of 20,000-records inthe ChemDiv database [26]: 1. Porphyrines.

Development and evaluation of human AP endonuclease inhibitors inmelanoma and glioma cell lines

M Z Mohammed; V N Vyjayanti; C A Laughton; L V Dekker; P M Fischer; D M Wilson; R Abbotts; S Shah; P M Patel; I D Hickson; S Madhusudan

Originaldocument: PMC | Score: 13.878843 | Text size: 53367 | Find: similardocuments

(Braunschweig,Germany), Enamine Ltd. (Kiev, Ukraine), Specs Chemicals (Delft, theNetherlands), ChemDiv Inc. (San Diego, CA, USA),Ukrorgsynthesis Ltd (Kiev, Ukraine) and Sigma-Aldrich.

Identification of a Chemical That Inhibits the Mycobacterial UvrABCComplex in Nucleotide Excision Repair†

Nayef Mazloum; Melanie A.Stegman;Deborah L.Croteau;Bennett VanHouten;Nyoun Soo Kwon; Yan Ling; CaitlynDickinson;Aditya Venugopal;Mohammad AtifTowheed;Carl Nathan

Originaldocument: PMC | Score: 14.363574 | Text size: 42116 | Find: similardocuments

High-ThroughputScreening Thirty-eight thousand compounds with drug-like properties from ChemDiv andChembridge were screened at the Rockefeller University-Weill Cornell MedicalCollege High

A novel small molecule target in human airway smooth muscle for potentialtreatment of obstructive lung diseases: a staged high-throughput biophysicalscreening

Steven S An; Peter S Askovich; Thomas IZarembinski;Kwangmi Ahn; John M Peltier; Moritz vonRechenberg;SudhirSahasrabudhe; Jeffrey JFredberg

Originaldocument: PMC | Score: 14.426556 | Text size: 38390 | Find: similardocuments

58,019structurally diverse chemical compounds were obtained from ChemBridge (SanDiego, CA) andChemDiv (San Diego, CA).

An Efficient New Route to Dihydropyranobenzimidazole Inhibitors of HCVReplication

Matthew A.Parker;Emily Satkiewicz; Thomas Hermann; B. MikaelBergdahl

PMC ID: PMC6259416 | DOI: 10.3390/molecules16010281 |Journal: Molecules, 16(1) pp. 281-290 |Publisher: MDPI | Publicationdate:2010-12-30

Original document: PMC | Score: 14.74994 | Text size: 24925 | Find: similardocuments

LeRoyLafferty for NMR support, and ChemDiv, Inc., for a generousdonation of equipment and supplies.

Chemical genetics approach to restoring p27Kip1 reveals novel compoundswith antiproliferative activity in prostate cancer cells

ElizabethRico-Bautista; Chih-Cheng Yang; Lifang Lu; Gregory P Roth; Dieter A Wolf

PMC ID: PMC3025922 | DOI: 10.1186/1741-7007-8-153 |Journal: BMC Biology, 8(1) pp. 153-153 |Publisher: BioMed Central | Publicationdate: 2010-12-23

Originaldocument: PMC | Score: 13.317075 | Text size: 77402 | Find: similardocuments

SMIP0019 waspurchased from ChemDiv, Inc (CA, USA).

Targeting the OB-Folds of Replication Protein A with Small Molecules

Victor J.Anciano Granadillo; Jennifer N.Earley;Sarah C. Shuck; Millie M.Georgiadis;Richard W. Fitch; John J. Turchi

Originaldocument: PMC | Score: 14.117049 | Text size: 41167 | Find: similardocuments

SMIs wasidentified from screening and analysis of structure activity relationships(SARs) of the ChemDiv library [12].

IKKβ inhibitor identification: amulti-filter driven novel scaffold

Shanthi Nagarajan; Hyunah Choo; Yong Seo Cho; Kye Jung Shin; Kwang-Seok Oh; Byung Ho Lee; Ae Nim Pae

PMC ID: PMC2957683 | DOI: 10.1186/1471-2105-11-S7-S15 |Journal: BMC Bioinformatics, 11(1) pp. S15-S15 |Publisher: BioMed Central |Publication date: 2010-10-15

Originaldocument: PMC | Score: 17.805475 | Text size: 36287 | Find: similardocuments

virtualscreening (VS) technique has been applied to identify IKKβ inhibitorsfrom the ChemDiv database with 0.7 million compounds. ...investigation, we have applied various computational models sequentially tovirtually screen the ChemDiv database, and identified a smallmolecule that has an IC50 value of 20.3μM. ... Virtual Screening Byusing the above mentioned models, we have been able to filter the ChemDiv database,that has approximately 0.7 million compounds (Fig. 3).

Gene Annotation and Drug Target Discovery in Candida albicans with aTagged Transposon Mutant Collection

Julia Oh; Eula Fung; Ulrich Schlecht; Ronald W. Davis; Guri Giaever; Robert P. St.Onge;AdamDeutschbauer; Corey Nislow; Scott G. Filler

Originaldocument: PMC | Score: 13.76273 | Text size: 87594 | Find: similardocuments

Drugscreening A diversity library was obtained from ChemDiv, Inc. anddissolved in DMSO.

Navigating the Human Metabolome for Biomarker Identification and Designof Pharmaceutical Molecules

IreneKouskoumvekaki; GianniPanagiotou

Originaldocument: PMC | Score: 17.21541 | Text size: 86538 | Find: similardocuments

drugs fromDrugBank v.2, as well as for a randomly selected subset of 59,025 compoundsfrom ChemDiv, a commercial provider of small compounds for drugdiscovery HTS. ... On the other hand, only 182 compounds from the subsetof ChemDiv were found similar to any human metabolite, formingjust 1,563 similarity pairs in total. This low similarity of ChemDiv couldbe attributed to the fact that HTS databases contain small molecules withsimple structures

Identification of Novel p53 Pathway Activating Small-Molecule CompoundsReveals Unexpected Similarities with Known Therapeutic Agents

Karita Peltonen; Laureen Colis; Hester Liu; SariJäämaa; Henna M. Moore; JuuliaEnbäck;Pirjo Laakkonen; Anne Vaahtokari; Richard J. Jones; Taija M. afHällström; Marikki Laiho; Joseph AlanBauer

PMC ID: PMC2946317 | DOI: 10.1371/journal.pone.0012996 |Journal: PLoS ONE, 5(1) | Publisher: PublicLibrary of Science | Publicationdate: 2010-09-27

Original document: PMC | Score: 13.996932 | Text size: 49987 | Find: similardocuments

Cells wereplated at 10,000 cells/well onto 96-well plates and treated at 3 μM (ChemDiv,Tripos) or 10 μM (SpectrumCollection) compound concentration for 24 h. Mock treatment (DMSO

Combinations of Physiologic Estrogens with Xenoestrogens Alter ERKPhosphorylation Profiles in Rat Pituitary Cells

Yow-Jiun Jeng; Cheryl S. Watson

Originaldocument: PMC | Score: 14.363574 | Text size: 46540 | Find: similardocuments

TheG-protein–coupled ER (GPER) agonist G1 was a gift from Chemdiv Inc. (SanDiego, CA) arranged by E. Prossnitz.

Reconstruction and flux-balance analysis of the Plasmodium falciparummetabolic network

GermánPlata;Tzu-Lin Hsiao; Kellen LOlszewski;ManuelLlinás; Dennis Vitkup

PMC ID: PMC2964117 | DOI: 10.1038/msb.2010.60 |Journal: Molecular Systems Biology, 6(1) pp. 408-408 |Publisher: Nature Publishing Group | Publicationdate: 2010-09-07

Originaldocument: PMC | Score: 16.360525 | Text size: 85455 | Find: similardocuments

Thecompounds 1_03 and 3_02 were acquired from ChemDiv (http://chemdiv.emolecules.com; ChemDiv IDs8003-6329 and 5350-0029, respectively) and resuspended at 100 mM in DMSO.

Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands withDistinct Modes of Pharmacology

Alexis S.Hammond;Alice L.Rodriguez;Steven D.Townsend;Colleen M. Niswender; Karen J. Gregory; Craig W. Lindsley; P. Jeffrey Conn

Originaldocument: PMC | Score: 13.648543 | Text size: 65341 | Find: similardocuments

ScreeningCenter compound collection was obtained from ChemBridge Corporation (San Diego,CA) andChemDiv, Inc. (San Diego, CA). l-Glutamate and MPEP wereobtained from Tocris Bioscience (Ellisville, MO).

Binding of Protein Kinase Inhibitors to Synapsin I Inferred fromPair-Wise Binding Site Similarity Measurements

Enrico DeFranchi;Claire Schalon; Mirko Messa; Franco Onofri; Fabio Benfenati; Didier Rognan; Floyd Romesberg

PMC ID: PMC2922380 | DOI: 10.1371/journal.pone.0012214 |Journal: PLoS ONE, 5(1) | Publisher: PublicLibrary of Science | Publicationdate: 2010-08-16

Original document: PMC | Score: 14.2392435 | Text size: 55498 | Find: similardocuments

San Diego,CA), 70159800251 (Otava, kiev, Ukraine), H-89 (LC Laboratories, Woburn, MA),4072–7730 (ChemDiv, San Diego, CA), R59022 and novobiocin (MPBiochemicals, Illkirch, France) and last CCT018059

Identification of Small Molecule Inhibitors of Clostridium perfringens ε -Toxin Cytotoxicity Using a Cell-BasedHigh-Throughput Screen

Michelle Lewis; Charles DavidWeaver;Mark S. McClain

PMC ID: PMC2922765 | DOI: 10.3390/toxins2071825 |Journal: Toxins, 2(1) pp. 1825-1847 |Publisher: MDPI | Publicationdate: 2010-07-09

Originaldocument: PMC | Score: 18.45006 | Text size: 48439 | Find: similardocuments

compoundsrepresents a diverse subset of the >1 million member inventories of twocompanies, ChemDivand ChemBridge. Each chemical is dissolved at aconcentration of 10 mM in dimethylsulfoxide. Confirmed hits and theirstructural analogs were acquired from commercial sources (ChemDiv,ChemBridge, and Specs) as dry powders and dissolved in DMSO. ... VanderbiltInstitute of Chemical Biology HTS facility has chemical libraries from twosources, ChemDiv and ChemBridge. The 151,616 chemicalsscreened in this assay are representative of the chemical diversity of thelarger ChemDiv and ChemBridge compound collections.

Inhibition of receptor tyrosine kinase signalling by small moleculeagonist of T-cell protein tyrosine phosphatase

Elina Mattila; Heidi Marttila; Niko Sahlberg; Pekka Kohonen; SiriTähtinen; Pasi Halonen; MerjaPerälä; Johanna Ivaska

PMC ID: PMC2820462 | DOI: 10.1186/1471-2407-10-7 |Journal: BMC Cancer, 10(1) pp. 7-7 |Publisher: BioMed Central | Publicationdate:2010-01-07

Originaldocument: PMC | Score: 18.470776 | Text size: 41249 | Find: similardocuments

DiscoverySystems, LOPAC (Library of Pharmacologically Active Compounds) 1280 fromSigma, ChemDiv fromChemDiv Inc., ChemBridge fromChemBridge Corporation, and Tripos from Tripos International. ... compounds,LOPAC1280 with 1280 pharmaceutically active compounds, Tripos with 6000 compounds,ChemDiv with25000 compounds and ChemBridge with 30000 compounds were screened in an invitro phosphatase ... LibraryCompoundsPrimary hitsConfirmed activators Tripos6000 5 1 ChemDiv 25000 23 1 ChemBridge 30000 167 0 MicrosourceSpectrum 2000 16 2 Sigma Lopac 1280 2 2 Total 64280 ... Five small moleculelibraries, the Spectrum Collection, LOPAC1280, ChemDiv, ChemBridgeand Tripos were screened for TCPTP activators.

Generation of 500-Member Library of10-Alkyl-2-R1,3-R2-4,10-DihydrobenzoDihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones

Svetlana M. Sirko; Nikolay Yu.Gorobets;Vladimir I.Musatov;Sergey M.Desenko

PMC ID: PMC6254725 | DOI: 10.3390/molecules14125223 |Journal: Molecules, 14(1) pp. 5223-5234 |Publisher: Molecular Diversity Preservation International | Publication date: 2009-12-15

Originaldocument: PMC | Score: 14.951023 | Text size: 25352 | Find: similardocuments

AcknowledgementsWe thank ChemDiv, Inc. San Diego, CA, USA for supporting thiswork.

Molecular Mechanism for Human Sperm Chemotaxis Mediated by Progesterone

Maria E. Teves; Hector A.Guidobaldi;Diego R.Uñates; Raul Sanchez; Werner Miska; Stephen J.Publicover;Aduén A.Morales Garcia; Laura C.Giojalas;Immo A. Hansen

PMC ID: PMC2782141 | DOI: 10.1371/journal.pone.0008211 |Journal: PLoS ONE, 4(1) | Publisher: PublicLibrary of Science | Publicationdate: 2009-12-08

Originaldocument: PMC | Score: 13.996932 | Text size: 55740 | Find: similardocuments

USA); HumanSerum Albumin (UNC, Argentina); Nifedipine, 2-APB (Calbiochem, Germany); KH7 (ChemDiv,USA); mouse monoclonal anti-phosphotyrosine, clone 4G10 (UPSTATE, USA); rabbitpolyclonal

Physiochemical property space distribution among human metabolites, drugsand toxins

Varun Khanna; ShobaRanganathan

PMC ID: PMC2788350 | DOI: 10.1186/1471-2105-10-S15-S10 |Journal: BMC Bioinformatics, 10(1) pp. S10-S10 |Publisher: BioMed Central |Publication date: 2009-12-03

Originaldocument: PMC | Score: 16.524874 | Text size: 56456 | Find: similardocuments

set ofmolecules from NPs obtained from four databases namely BioSPECS natural productdatabase,ChemDiv natural product database, Interbioscreeen IBS2001Nand HTS-NC database, drugs obtained from ... obtained from (MayBridge HTSdatabase, ChemBridge EXPRESS-Pick database ComGenex Collection,ChemDiv Collectionand SPECS screening compound database).

Translocation Biosensors – Cellular System Integrators to DissectCRM1-Dependent Nuclear Export by Chemicogenomics

Verena Fetz; Shirley K.Knauer;Carolin Bier; Jens Peter vonKries;Roland H.Stauber

PMC ID: PMC3274152 | DOI: 10.3390/s90705423 |Journal: Sensors (Basel, Switzerland), 9(1) pp. 5423-5445 |Publisher: Molecular Diversity Preservation International (MDPI) | Publication date: 2009-07-09

Originaldocument: PMC | Score: 13.996932 | Text size: 58089 | Find: similardocuments

Compoundswere purchased from ChemDiv (San Diego, CA, USA) and dissolvedin DMSO (50 mM).

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expandscardiac cell lineages

Gabriela Molina; Andreas Vogt; Ahmet Bakan; Weixiang Dai; Pierre Queirozde Oliveira;Wade Znosko; Thomas E.Smithgall;Ivet Bahar; John S. Lazo; Billy W. Day; Michael Tsang

Originaldocument: PMC | Score: 14.117049 | Text size: 44421 | Find: similar documents

the NaturalProducts library (MicroSource Discovery Systems Inc.) and Phosphatase targetedset (ChemDiv Inc.) were screened in this study.

Small-Molecule Activators of Insulin-Degrading Enzyme Discovered throughHigh-Throughput Compound Screening

ChristelleCabrol;Malwina A.Huzarska;ChristopherDinolfo;Maria C.Rodriguez;Lael Reinstatler; Jake Ni; Li-An Yeh; Gregory D. Cuny; Ross L. Stein;Dennis J. Selkoe; Malcolm A.Leissring;Andreas Hofmann

PMC ID: PMC2668070 | DOI: 10.1371/journal.pone.0005274 |Journal: PLoS ONE, 4(1) | Publisher: PublicLibrary of Science | Publicationdate: 2009-04-22

Originaldocument: PMC | Score: 14.363574 | Text size: 39120 | Find: similardocuments

(Ilkirch,France), Specs and Biospecs (CP Rijswijk, the Netherlands), ENAMINE (Kiev,Ukraine), and ChemDiv(San Diego, CA). Ia1 and Ia2 were purchasedfrom Bionet. SP1 was synthesized by SynPep Corp.

Chemical Probes that Competitively and Selectively Inhibit Stat3Activation

Xuejun Xu; Moses M.Kasembeli;Xueqing Jiang; Benjamin J.Tweardy;David J. Tweardy; Harald H. H. W.Schmidt

PMC ID: PMC2653189 | DOI: 10.1371/journal.pone.0004783 |Journal: PLoS ONE, 4(1) | Publisher: PublicLibrary of Science | Publicationdate: 2009-03-10

Originaldocument: PMC | Score: 16.44229 | Text size: 53112 | Find: similardocuments

Commercialchemical databases (ChemBridge, Asinex, ChemDiv, Enamine,KeyOrganics and LifeChemicals) were chosen as sources of compounds forscreening in ... The databases searched included ChemBridge, LifeChemicals,Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for atotal of 2.47 million compounds.

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacteriumtuberculosis Screen Hit

Chiung-KuangChen;Patricia S.Doyle;Liudmila V.Yermalitskaya; Zachary B.Mackey;Kenny K. H. Ang; James H. McKerrow; Larissa M.Podust;Greg Matlashewski

Originaldocument: PMC | Score: 17.646307 | Text size: 42398 | Find: similardocuments

DataCollection, and Determination of Crystal Structure Five compounds (Fig. 2),purchased from ChemDiv (San Diego, California) were used for co-crystallizationwith the CYP51Mt C37L/C442A double mutant. ... structures and bindingaffinities of compounds. 1Compounds are identified by the numbers in the ChemDiv,Inc., product library catalog. 10.1371/journal.pntd.0000372.t001 Table 1Crystallographic data and statistics. Compound # Compound 8 Compound 9 Compound11 ChemDiv # 4596-0233 C155-0065 C155-0337 PDB ID 2W0B 2W092W0A Data collection Wavelength, Å 1.0000 1.0000

Golgicide A reveals essential roles for GBF1 in Golgi assembly andfunction

Jose B. Saenz; William J. Sun; Jae Won Chang; Jinmei Li; Badry Bursulaya; Nathanael S.Gray;David B. Haslam

Originaldocument: PMC | Score: 13.996932 | Text size: 47015 | Find: similar documents

characterizationof GCA GCA was identified from a commercial compound library availablefrom ChemDiv.

Glucose and GLP-1 Stimulate cAMP Production via Distinct AdenylylCyclases in INS-1E Insulinoma Cells

Lavoisier S.Ramos;Jonathan HaleZippin;Margarita Kamenetsky; Jochen Buck; Lonny R. Levin

Originaldocument: PMC | Score: 14.117049 | Text size: 47594 | Find: similardocuments

KH7 wassynthesized by ChemDiv, Inc. or by the Milstein Chemical CoreFacility of Weill Medical College of Cornell University.

Identification of Small Molecule Inhibitors of Pseudomonas aeruginosaExoenzyme S Using a Yeast Phenotypic Screen

Anthony Arnoldo; Jasna Curak; SaranyaKittanakom;Igor Chevelev; Vincent T. Lee; MehdiSahebol-Amri; Becky Koscik; Lana Ljuma; Peter J. Roy;Antonio Bedalov; Guri Giaever; Corey Nislow; Rod A. Merrill; Stephen Lory; Igor Stagljar; Michael Snyder

Originaldocument: PMC | Score: 13.536236 | Text size: 68024 | Find: similardocuments

Sigma-Aldrich),the SPECTRUM library (2,000 compounds, MicroSource Discovery Inc.) and a ChemDiv library(53,000 compounds) were screened at a final concentration of 50 μM.

Calcium-sensing soluble adenylyl cyclase mediates TNF signal transductionin human neutrophils

Hyunsil Han; AlexanderStessin;Julia Roberts; Kenneth Hess; Narinder Gautam; MargaritaKamenetsky;Olivia Lou; Edward Hyde; Noah Nathan;William A.Muller;Jochen Buck; Lonny R. Levin; Carl Nathan

Originaldocument: PMC | Score: 13.996932 | Text size: 46151 | Find: similardocuments

A collectionof 15,000 compounds with drug-like characteristics from ChemDiv Labswas screened robotically in the High Throughput Screening Facility at TheRockefeller

Discovery of Glycine Hydrazide Pore-occluding CFTR Inhibitors

ChatchaiMuanprasat;N.D. Sonawane; Danieli Salinas; AlessandroTaddei;Luis J.V.Galietta;A.S. Verkman

Originaldocument: PMC | Score: 13.536236 | Text size: 54001 | Find: similardocuments

molecules(most 250–550 D) were selected for screening from commercial sources(ChemBridge andChemDiv) using algorithms designed to maximize chemicaldiversity and drug-like properties.

Structural model of nicotinic acetylcholine receptor isotypes bound toacetylcholine and nicotine

MatthieuSchapira;Ruben Abagyan; Maxim Totrov

PMC ID: PMC65631 | DOI: 10.1186/1472-6807-2-1 |Journal: BMC Structural Biology, 2(1) pp. 1-1 |Publisher: BioMed Central | Publicationdate: 2002-01-18

Originaldocument: PMC | Score: 17.77341 | Text size: 28361 | Find: similardocuments

be specificfor beta2-containing nAChR subtypes, we searched a database of over 200,000compounds (ChemDiv Inc., San Diego, CA), for alpha4-beta2 ligandcandidates presenting a functional group close to Ala 135 ... ligand wassimilar than the grid docking previously described [21]: each flexible ligandof the ChemDivpublic library (ChemDiv Inc., San Diego) wasdocked automatically into the combination of potential maps described above,and

Identification of new potent A1 adenosine receptor antagonists using amultistage virtual screening approach

Yu Wei; Mukuo Wang; Yang Li; Zhangyong Hong; Dongmei Li; Jianping Lin

DOI: 10.1016/j.ejmech.2019.111936 |ISSN: 1768-3254,0223-5234 | Journal: European journal of medicinal chemistry, 187 pp.111936-111936 | Publisher: EditionsScientifiques Elsevier | Publication date: 2019-12-04 | Printpublication date: 2019-12-04

Originaldocument: Medline | Score: 21.96154 | Text size: 2134 | Find: similardocuments

ChemDiv library(1,492,362 compounds).

Identification of peptidomimetic compounds as potential inhibitorsagainst MurA enzyme of Mycobacterium tuberculosis

Prateek Kumar; Kumar UditSaumya;Rajanish Giri

Originaldocument: Medline | Score: 25.324753 | Text size: 1964 | Find: similardocuments

strategy, wehave designed this study where two libraries of peptidomimetic compounds(Asinex & ChemDiv) were first screened against our modeled MurAstructure and then validated through molecular dynamic simulations. From ourvirtual screening, top four compounds (ChemDiv: D675-0102, D675-0217;Asinex: BDE25373574, BDE 26717803) were selected based on their docking

A Chemosensory GPCR as a Potential Target to Control the Root-KnotNematode Meloidogyne incognita Parasitism in Plants

Emmanuel Bresso; Diana Fernandez; Deisy X Amora; Philippe Noel; Anne-SophiePetitot;Maria-EugêniaLisei de Sa;Erika V SAlbuquerque;Etienne G J Danchin; Bernard Maigret; Natália FMartins

Originaldocument: Medline | Score: 22.316162 | Text size: 1604 | Find: similardocuments

selectedmolecules allowed the identification of an active compound, namely C260-2124,from the ChemDivprovider, which can serve as a starting point forfurther investigations.

Structural optimization on a virtual screening hit of smoothened receptor

Shiwei Song; Jinyi Jiang; Li Zhao; Qin Wang; Wenfeng Lu; Chaonan Zheng; Jie Zhang; Haikuo Ma; Sheng Tian; Jiyue Zheng; Lusong Luo; Youyong Li;Zeng-Jie Yang; Xiaohu Zhang

DOI: 10.1016/j.ejmech.2019.03.057 |ISSN: 1768-3254,0223-5234 | Journal: European journal of medicinal chemistry, 172 pp. 1-15 |Publisher: EditionsScientifiques Elsevier | Publicationdate: 2019-03-26 | Print publication date: 2019-06-15

Originaldocument: Medline | Score: 21.122412 | Text size: 2638 | Find: similardocuments

The mostpotent compound (ChemDiv ID C794-1677: 47 nM) showed comparable Hhsignaling inhibition to the marketed drug vismodegib (46

Chemical Space Overlap with Critical Protein-Protein Interface Residuesin Commercial and Specialized Small-Molecule Libraries

Yubing Si; David Xu; KhuchtumurBum-Erdene;Mona K Ghozayel; Baocheng Yang; Paul A Clemons; Samy O Meroueh

Originaldocument: Medline | Score: 20.804443 | Text size: 3341 | Find: similardocuments

ChemDiv), acollection of diversity-oriented synthesis (DOS) compounds that containsnatural-product-like

Identification of a novel c-Myc inhibitor with antitumor effects onmultiple myeloma cells

Ruosi Yao; Xiaoyang Sun; Yu Xie; Xiaoshen Sun; Yao Yao; Hujun Li; Zhenyu Li; Jian Gao; Kailin Xu

Originaldocument: Medline | Score: 21.285069 | Text size: 1980 | Find: similardocuments

ChemDiv compounddatabase by molecular docking-based, high-throughput virtual screening.

Discovery of potent and novel smoothened antagonists via structure-basedvirtual screening and biological assays

Wenfeng Lu; Dihua Zhang; Haikuo Ma; Sheng Tian; Jiyue Zheng; Qin Wang; Lusong Luo; Xiaohu Zhang

DOI: 10.1016/j.ejmech.2018.05.035 |ISSN: 1768-3254,0223-5234 | Journal: European journal of medicinal chemistry, 155 pp. 34-48 |Publisher: EditionsScientifiques Elsevier | Publicationdate: 2018-05-23 | Print publication date: 2018-07-15

Originaldocument: Medline | Score: 20.649023 | Text size: 3052 | Find: similardocuments

moleculardocking-based virtual screening was conducted to identify promising Smoantagonists fromChemDiv library.

Adversarial Threshold Neural Computer for Molecular de Novo Design

Evgeny Putin; Arip Asadulaev; QuentinVanhaelen;Yan Ivanenkov; Anastasia VAladinskaya;Alex Aliper; Alex Zhavoronkov

Originaldocument: Medline | Score: 22.316162 | Text size: 2231 | Find: similardocuments

The SMILESrepresentations of 15K druglike molecules from the ChemDiv collectionwere used as a training data set. For the different functions, ATNC outperformsORGANIC.

Virtual Screening of Small Molecular Inhibitors against DprE1

Gang Zhang; Song Guo; Huaqing Cui; Jianguo Qi

Originaldocument: Medline | Score: 21.87464 | Text size: 1534 | Find: similardocuments

ChemDiv datasetthrough virtual screening based on pharmacophore and molecular docking.

Discovery of non-peptidic small molecule inhibitors of cyclophilin D asneuroprotective agents in Aβ-inducedmitochondrial dysfunction

Insun Park; Ashwini M Londhe; Ji Woong Lim; Beoung-Geon Park; Seo Yun Jung; Jae Yeol Lee; Sang Min Lim; Kyoung Tai No; Jiyoun Lee; Ae Nim Pae

Originaldocument: Medline | Score: 20.804443 | Text size: 2674 | Find: similardocuments

structure ofCypD-cyclosporine A (CsA) complex and performed virtual screening of ChemDiv database,which yielded forty-five potential hit compounds with novel scaffolds.

In silico probing and biological evaluation of SETDB1/ESET-targeted novelcompounds that reduce tri-methylated histone H3K9 (H3K9me3) level

Insun Park; Yu Jin Hwang; TaeHun Kim; Ambily Nath InduViswanath;Ashwini M Londhe; Seo Yun Jung; Kyoung Mi Sim; Sun-Joon Min; Ji Eun Lee;Jihye Seong; Yun Kyung Kim; Kyoung Tai No; Hoon Ryu; Ae Nim Pae

Originaldocument: Medline | Score: 21.122412 | Text size: 2508 | Find: similardocuments

pharmacophoremodel was built and employed for the virtual screening of ChemDiv andAsinex database.

Fusion of Structure and Ligand Based Methods for Identification of NovelCDK2 Inhibitors

Priya Mahajan; Gousia Chashoo; Monika Gupta; Amit Kumar; Parvinder PalSingh;Amit Nargotra

DOI: 10.1021/acs.jcim.7b00293 |ISSN: 1549-960X,1549-9596 | Journal: Journal of chemical information and modeling, 57(8)pp. 1957-1969 |Publisher: American Chemical Society | Publicationdate: 2017-08-03 | Print publication date: 2017-08-28

Originaldocument: Medline | Score: 21.533804 | Text size: 2024 | Find: similardocuments

A druglikelibrary of 50,000 compounds from ChemDiv and ChemBridgedatabases was screened against CDK2, and 110 compounds were identified usingthe

3D Pharmacophore-Based Virtual Screening and Docking Approaches towardthe Discovery of Novel HPPD Inhibitors

Ying Fu; Yi-Na Sun; Ke-Han Yi; Ming-Qiang Li; Hai-Feng Cao; Jia-Zhong Li; Fei Ye

Originaldocument: Medline | Score: 25.209267 | Text size: 2228 | Find: similardocuments

ChemDiv databasewas screened using CBP-Hypo2 as a 3D query, and the best-fit hits subjected tomolecular ... Keywords ChemDiv HPPD inhibitors HipHop modelmolecule docking pharmacophore model virtual screening MeSH

Identification of Novel Small-Molecule ASGP-R Ligands

Alexander GMajouga;Yan A Ivanenkov; Mark S Veselov; Anton V Lopuhov; Svetlana VMaklakova;Elena KBeloglazkina; Petr V Binevski; Natalya LKlyachko;Yuri BSandulenko;Natalia YGalkina;Victor EKoteliansky

Originaldocument: Medline | Score: 22.13743 | Text size: 1513 | Find: similardocuments

ChemDiv collectionand compounds provided by our colleagues to reveal potential ASGP-R binders.

Discovery of new Mycobacterium tuberculosis proteasome inhibitors using aknowledge-based computational screening approach

Rukmankesh Mehra; Reena Chib; GurunadhamMunagala;Kushalava ReddyYempalla;Inshad Ali Khan; Parvinder PalSingh;Farrah Gul Khan; Amit Nargotra

Originaldocument: Medline | Score: 21.702883 | Text size: 2179 | Find: similardocuments

ChemDiv (30,000compounds) databases.

Identification and optimization of Escherichia coli GlmU inhibitors: anin silico approach with validation thereof

Rukmankesh Mehra; Rashmi Sharma; Inshad Ali Khan; Amit Nargotra

DOI: 10.1016/j.ejmech.2014.12.030 |ISSN: 1768-3254,0223-5234 | Journal: European journal of medicinal chemistry, 92 pp. 78-90 |Publisher: EditionsScientifiques Elsevier | Publicationdate: 2014-12-18 | Print publication date: 2015-03-06

Originaldocument: Medline | Score: 21.367338 | Text size: 2185 | Find: similardocuments

ChemDiv databases.

Ethyl2-(benzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylateanalogues as a new scaffold for protein kinase casein kinase 2 inhibitor

Cheng-Hao Jin; Kyu-Yeon Jun; Eunjung Lee; Seongrak Kim; Youngjoo Kwon; Kunhong Kim; Younghwa Na

Originaldocument: Medline | Score: 21.122412 | Text size: 3074 | Find: similardocuments

ChemDiv chemicallibraries (2000: randomly selected; 2000: kinase-biased) and performed in vitrokinase

Virtual screening and synthesis of novel antitubercular agents throughinteraction-based pharmacophore and molecular docking studies

Deepak Bhattarai; MuhammadMuddassar;Jae Wan Jang; Seung Kon Hong; Eunice EunkyeongKim;Taegwon Oh; Sang-Nae Cho; Ae Nim Pae;Gyochang Keum

Originaldocument: Medline | Score: 21.533804 | Text size: 2250 | Find: similardocuments

ChemDiv database.

Identification of dual Acetyl-CoA carboxylases 1 and 2 inhibitors bypharmacophore based virtual screening and molecular docking approach

AnuseemaBhadauriya;Gaurao V Dhoke; Rahul P Gangwal; Mangesh V Damre; Abhay TSangamwar

Originaldocument: Medline | Score: 22.005249 | Text size: 1746 | Find: similardocuments

pharmacophoremodels were used to screen several small-molecule databases, including Specs,NCI,ChemDiv and Natural product databases to identify the potentialdual ACC inhibitors.

Targeting the transposase domain of the DNA repair component Metnase toenhance chemotherapy

Elizabeth AWilliamson;Leah Damiani; Andrei Leitao; Chelin Hu; Helen Hathaway; Tudor Oprea; Larry Sklar; Montaser Shaheen; Julie Bauman; Wei Wang; Jac A Nickoloff; Suk-Hee Lee; Robert Hromas

Originaldocument: Medline | Score: 20.804443 | Text size: 2425 | Find: similardocuments

ChemDiv libraryto identify small molecules that might dock in the active site of thetransposase nuclease

Application of validated QSAR models of D1 dopaminergic antagonists fordatabase mining

Scott Oloff; Richard BMailman;AlexanderTropsha

Originaldocument: Medline | Score: 22.093195 | Text size: 2350 | Find: similardocuments

(NCI)database of ca. 250,000 compounds, the Maybridge Database of ca. 56,000compounds, and theChemDiv Database of ca. 450,000 compounds. These searchesresulted in only 54 consensus hits (i.

Kinase inhibitor recognition by use of a multivariable QSAR model

D G Sprous; John Zhang; Lei Zhang; Zhaolin Wang; M A Tepper

Originaldocument: Medline | Score: 22.316162 | Text size: 2265 | Find: similardocuments

We appliedthis model to evaluate the commercial kinase libraries available from Asinex,BioFocus, ChemDivand LifeChemicals to facilitate purchase decisionsfor compounds for HTS for lead compounds.

SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)

LIST, Alan F.[US];WEI, Sheng [US]

Publicationdate: 2020-01-08 | Patent publication No.: EP-3016512-B1|Assignees: H. Lee Moffitt Cancer Center And Research Institute, Inc. [US] | IPC: A01N25/00;A61K39/00; C12P21/04 | Oldestpriority date: 2014-04-10 | Publication date: 2020-01-08

Score: 11.569273 | Text size: 173774 | Find: similardocuments

ChemBridgeCorporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA, www.chembridge.com);ChemDiv (6605Nancy Ridge Drive, San Diego, CA 92121, USA); Life Chemicals (1103 OrangeCenter Road,

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METHOD TO DETECT ACTIVITY OF A POLYMERASE

BERGBREDE, Tim[DE];LARSSON,Nils-Göran [DE]; GUSTAFSSON,Claes [SE];FALKENBERG-GUSTAFSSON,Maria [SE]

Publicationdate: 2020-01-08 | Patent publication No.: EP-3303613-B1|Assignees: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. [DE];Lead Discovery Center GmbH [DE] | IPC: C12Q1/68 | Oldestpriority date: 2015-05-29 | Publication date: 2020-01-08

Score: 13.327991 | Text size: 122895 | Find: similardocuments

in the assaywas 4-methyl-5-[2-(pyrimidin-2-ylamino)thiazol-4yl]thiazol-2-amine (availableat ChemDiv) and is applied using contact-free acousticdroplet-dispensing (Labcyte Echo®) from 10 mM compound

External link

COMPOSITIONS AND METHODS FOR INHIBITION OF AUTOPHAGY

Elizabeth J.Goldsmith [US]; Alexander T.Piala [US];Malia B. Potts[US]

Publicationdate: 2020-01-02 | Patent publication No.: US-20200000806-A1|Assignees: Board of Regents, The University of Texas System [US] | IPC: A61K31/517;A61K31/427; A61K31/428 | Oldestpriority date: 2016-05-26 | Publication date: 2020-01-02

Score: 14.293713 | Text size: 60848 | Find: similardocuments

These 13compounds were purchased from Chembridge Inc. and ChemDiv Inc. formeasurement of direct binding using Differential Scanning Fluorimetry (DSF).

INHIBITORS OF HIV-1 INTEGRASE MULTIMERIZATION

Mark D. ANDRAKE[US];Anna MarieSKALKA [US];George W. Merkel[US]

Publicationdate: 2019-12-19 | Patent publication No.: US-20190381054-A1|Assignees: Institute for Cancer Research d/b/a The Research Institute of Fox ChaseCancer Center [US] | IPC: A61K31/53; A61K31/4245; A61K31/454 | Oldest priority date: 2017-01-26 | Publication date: 2019-12-19

Score: 17.30191 | Text size: 55022 | Find: similardocuments

formation(see FIG. 1B), and used it to screen the 50,000 compound chemical diversitylibrary of ChemDiv, ltd. at 10 uM concentration. ... day wereperformed to screen the entire Chemical Diversity set of 50,000 compoundsobtained from ChemDiv, Ltd.

METHODS FOR TREATMENT OF RETINAL DISEASE BY PHOTORECEPTOR GENE EXPRESSIONMODULATION

Thomas A. Reh[US];Paul Nakamura[US];Sheng Ding [US]

Publicationdate: 2019-12-19 | Patent publication No.: US-20190381047-A1|Assignees: University of Washington [US]; The J. David Gladstone Institutes, aTestamentary Trust Established Under the Will of J. David Glads [US] | IPC: A61K31/519;C07D495/04; A61K31/426; A61K9/00; A61P27/02 | Oldest priority date: 2015-03-27 | Publication date: 2019-12-19

Score: 18.390413 | Text size: 53739 | Find: similar documents

(I) isCA8801: [[image:EMI-C00006]] Compounds CA88 and CA8801 are commerciallyavailable from ChemDiv(San Diego, Calif. ... (II) is CA9513:[[image:EMI-C00010]] Compounds CA95 and CA9513 are commercially availablefrom ChemDiv (San Diego, Calif. ... Nr2e3 interactingmolecules specifically identified herein were obtained commercially from ChemDiv (SanDiego, Calif.

Osteocalcin as a treatment for cognitive disorders

Gerard Karsenity[US];Franck Oury [US]

Score: 10.089907 | Text size: 305978 | Find: similardocuments

MaybridgeHitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352compounds);ChemDiv Combilab and International (28,864 compounds);Mixed Commercial Plate 1 (352 compounds); Mixed

COMPOUNDS COMPRISING LINKED HETERO ARYL MOIETIES AND THEIR USE AS NOVELUMAMI FLAVOR MODIFIERS, TASTANTS AND TASTE ENHANCERS FOR COMESTIBLECOMPOSITIONS

TACHDJIAN,Catherine [US]; WALLACE, David[US];LEBL-RINNOVA,Marketa [US]

Publicationdate: 2019-12-18 | Patent publication No.: EP-1850681-B1|Assignees: Firmenich Incorporated [US] | IPC: A23L27/20; A23L27/26; A23L2/56; A23L23/00; A23L2/02; A61K31/395;C07D401/12; C07D401/14 | Oldestpriority date: 2005-02-04 | Publication date:2019-12-18

Score: 11.239684 | Text size: 190835 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, PA, ChemDiv of San Diego, CA, Chembridge of SanDiego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the

External link

Inhibitors of RAD52 Recombination Protein and Methods Using Same

Alexander V.MAZIN [US]

Publicationdate: 2019-12-12 | Patent publication No.: US-20190375761-A1|Assignees: DREXEL UNIVERSITY [US] | IPC: C07D495/04; C07D491/056; C07D307/82; A61K45/06; A61K31/55; A61K31/5377;A61K31/517; A61K31/496; A61K31/4741; A61K31/4525; A61P35/00; C07D471/04;C07D239/95; C07D405/12; C07D215/38 | Oldestpriority date: 2015-06-04 | Publication date: 2019-12-12

Score: 12.484504 | Text size: 132719 | Find: similardocuments

Thecompounds for confirmation analysis were purchased from Asinex Ltd., ChemBridgeCo., ChemDiv Inc, Enamine, FCH Group, Frontier Scientific ServicesInc., InterBioScreen Ltd., Life Chemicals Inc.

MASP-2 INHIBITORS AND METHODS OF USE

Neil S. Cutshall[US];Jennifer LynnGage [US];Franz A.Gruswitz [US]; Juhienah Khalaf[US];Thomas L. Little[US];Markus Metz [US]; Jeremiah H.Nguyen [US];Peter KurtNollert von Specht [US]; Jennifer Tsoung[US];MichaelCicirelli [US]; Sara RebeccaGoldstein [US]; Santosh KumarKeshipeddy [US]; Do Yeon Kwon[US];Robert HuertaLemus [US];Sudheer BabuVaddela [US]

Publicationdate: 2019-12-05 | Patent publication No.: US-20190367452-A1|Assignees: Omeros Corporation [US] | IPC: C07D205/04; C07D211/60; C07D401/12; C07D217/14; C07C251/24; C07D213/73;C07D239/94; C07D235/30; C07D207/24; C07D295/135; C07C235/88; C07D295/033;C07D257/04; C07D207/16; C07D207/36; C07D295/26; C07D213/81; C07D417/12;C07D277/56; C07D231/44; C07D471/04; C07D233/64; C07D403/12; C07D249/08;C07D401/14; C07D417/14; C07D471/06; C07D413/12; C07D409/14; C07D495/04;C07D409/10; C07D413/14; C07D401/06; C07D403/06; C07D239/96 | Oldest priority date: 2018-05-29 | Publication date: 2019-12-05

Score: 8.340613 | Text size: 1173407 | Find: similardocuments

In certainaspects, a ChemDiv library (12760 High Bluff Drive, Suite 370,San Diego, Calif. 92130 USA) is used. The ChemDiv libraryoffers a wide variety of compounds including more than 1.5 M individual solidscreening

MASP-2 INHIBITORS AND METHODS OF USE

METZ, Markus[US];GOLDSTEIN, SaraRebecca [US]; KESHIPEDDY,Santosh Kumar [US]; KWON, Do Yeon[US];LEMUS, RobertHuerta [US];VADDELA, SudheerBabu [US];CUTSHALL, NeilS. [US];GAGE, JenniferLynn [US];GRUSWITZ, FranzA. [US];KHALAF, Juhienah[US];LITTLE, ThomasL. [US];NGUYEN, JeremiahH. [US];NOLLERT VONSPECHT, Peter Kurt [US]; TSOUNG, Jennifer[US];CICIRELLI,Michael [US]; METZ, Markus[US];GOLDSTEIN, SaraRebecca [US]; KESHIPEDDY,Santosh Kumar [US]; KWON, Do Yeon[US];LEMUS, RobertHuerta [US];VADDELA, SudheerBabu [US]

Score: 8.340613 | Text size: 1086216 | Find: similardocuments

is a publicaccess service for structure-based ligand discovery. [0203] In certain aspects,a ChemDiv library (12760 High Bluff Drive, Suite 370, SanDiego, CA 92130 USA) is used. The ChemDiv library offers awide variety of compounds including more than 1.5 M individual solid screening

INHIBITION OF FOLLISTATIN

HOUSEY, Gerard,M. [US];BALASH, Monica,E. [US];HOUSEY, Gerard,M. [US]

Score: 12.290053 | Text size: 157205 | Find: similardocuments

and includeAMRI library, AnalytiCon, BioFocus DPI Library, Chem-XInfmity, ChemBridgeLibrary, ChemDivLibrary, Enamine Library, The Greenpharma NaturalCompound Library, Life Chemicals Library,

HIGH PRECISION SPECTRAL FRET ASSAYS

Tory M. Schaaf[US];David D. Thomas[US];Benjamin Grant[US];Kurt C. Peterson[US];Gregory D.Gillispie [US]

Publicationdate: 2019-11-21 | Patent publication No.: US-20190353663-A9|Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA [US] | IPC: G01N33/68;G01N33/52; G01N33/542; G01N33/58 | Oldestpriority date: 2017-01-25 | Publication date: 2019-11-21

Score: 11.918776 | Text size: 202839 | Find: similardocuments

and includeAMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridgeLibrary, ChemDivLibrary, Enamine Library, The Greenpharma NaturalCompound Library, Life Chemicals Library,

Flavivirus protease inhibitors

RadhakrishnanPadmanabhan [US]; TadahisaTeramoto [US]; Mark Manzano[US]

Publicationdate: 2019-11-12 | Patent publication No.: US-10471082-B2|Assignees: Georgetown University [US] | IPC: A61K31/7032; A61K31/519; A61K31/12; A61K31/352; A61K31/415; A61K31/426;A61K31/44; A61K31/7034; A61K31/4178; A61K45/06 | Oldest priority date:2012-10-23 | Publication date: 2019-11-12

Score: 14.971729 | Text size: 52283 | Find: similardocuments

from, forexample, Alfa Aesar (Ward Hill, Mass.); ChemBridge Corporation (San Diego,Calif.); ChemDiv (San Diego, Calif.); and WaterstoneTechnology (Carmel, Ind.). IV.

FERROCHELATASE INHIBITORS AND METHODS OF USE

CORSON, TimothyW. [US];SEO, Seung-Yong[KR];LEE, Bit [KR]

Publicationdate: 2019-11-07 | Patent publication No.: WO-2019213076-A1|Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US]; GACHONUNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR] | IPC: A61K31/522;C07D487/04 | Oldestpriority date: 2018-04-30 | Publication date: 2019-11-07

Score: 16.068731 | Text size: 145281 | Find: similardocuments

at theIndiana University School of Medicine Chemical Genomics Core Facility (CGCF)using the ChemDiv 10K and a portion (10,000 compounds) of theChemBridge 50K libraries of chemical compounds. ... IC50 determinationCompounds, reordered from ChemDiv or synthesized as describedabove, were made to 10 mM in DMSO and tested in the FECH enzymatic

SLC26A3 INHIBITORS AND USE THEREOF

VERKMAN, Alan S.[US];CIL, Onur [US]; HAGGIE, Peter M.[US]

Publicationdate: 2019-10-31 | Patent publication No.: WO-2019210103-A2|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/37;A61K31/4164; A61K31/472; A61P1/10; C07D311/42 | Oldest priority date: 2018-04-25 | Publication date: 2019-10-31

Score: 17.506392 | Text size: 107835 | Find: similardocuments

Initialscreening was done of -50,000 drug-like synthetic small molecules (ChemDiv,San Diego, CA) at a concentration of 25 mM using a Cl /T exchange protocol toassay slc26a3 function. Following initial screening, compound analogs werepurchased (ChemDiv, San Diego, CA) to generate structure-activity data.... After initial screening, analogs of active compounds were purchased (ChemDiv)to generate structure-activity relationship data.

PROTEOSTASIS REGULATORS

FOLEY, Megan[US];TAIT, Bradley[US];CULLEN, Matthew[US]

Score: 10.354719 | Text size: 282678 | Find: similar documents

Compound A47(also shown below) was purchased from ChemDiv, San Diego, CA.

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Inhibitors of RAD52 recombination protein and methods using same

Alexander V.Mazin [US]

Publicationdate: 2019-10-15 | Patent publication No.: US-10442817-B2|Assignees: Drexel University [US] | IPC: C07D215/38; C07D405/12; C07D239/95; C07D471/04; C07D495/04; A61K31/517;A61K31/496; A61K31/55; A61K31/47; A61K45/06; A61P35/00; C07D491/048;A61K31/4525; A61K31/4741; A61K31/5377; C07D307/82; C07D491/056; A61K31/4188 | Oldest priority date: 2015-06-04 | Publication date:2019-10-15

Score: 12.484504 | Text size: 136518 | Find: similardocuments

Thecompounds for confirmation analysis were purchased from Asinex Ltd., ChemBridgeCo., ChemDiv Inc, Enamine, FCH Group, Frontier Scientific ServicesInc., InterBioScreen Ltd., Life Chemicals Inc.

NOVEL ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE

Bonnie L.Bassler [US]; Nina M.Hoyland-Kroghsbo [DK]; Jon E.Paczkowski [US]

Publicationdate: 2019-10-10 | Patent publication No.: US-20190307818-A1|Assignees: The Trustees of Princeton University [US] | IPC:A61K35/76; A61K45/06; A61P31/04; A01N63/00; G01N33/68; A61K31/353;A61K31/12; A61K31/44; A61K31/381; A61K31/365; A23L3/3454 |Oldest prioritydate: 2016-04-08 | Publication date: 2019-10-10

Score: 14.450268 | Text size: 180781 | Find: similardocuments

made to 10mM and stored at −20° C.. lab Princeton Chemistry Department Various(TCI, ChemBridge,ChemDiv, Cayman Chemicals, Santa Cruz Chemicals, ALFAAESA) Arabinose inducer 10% w/v in H2O (autoclaved, ... Princeton ChemistryDepartment Various (TCI, ChemBridge, ChemDiv, Cayman Chemicals,Santa Cruz Cehmicals, ALFA AESA) Arabinose inducer stock 10% w/v in H2O

TRPC4 INHIBITORS AND USES THEREOF

CRAWFORD, John,Stuart [US];OSTERTAG, Eric[US]

Score: 12.290053 | Text size: 124973 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigrna-Aldrich (St.Louis, Mo.

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GLUN2C/D SUBUNIT SELECTIVE ANTAGONISTS OF THE N-METHYL-D-ASPARTATERECEPTOR

LIOTTA, DennisC. [US];TRAYNELIS,Stephen F. [US]; JING, Yao [US]

Score: 13.10661 | Text size: 133326 | Find: similardocuments

lT7-pyrazol-l-yl)-4-oxobutanoicacid (DQP-1105) was selected from a Ca2+-based screen of ChemDiv andAsinex diversity libraries as GluN2C/D-selective antagonists [75,76] andexhibited inhibition

Methods of treating muscular dystrophy

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2019-09-03 | Patent publication No.: US-10398749-B2|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THEUNIVERSITY OF NEVADA, RENO [US] | IPC: A61K38/05; A61K31/496; A61K31/4985; A61K31/506; A61K38/39; A61K31/5375;A61K31/343; A61K31/4418; A61K31/444; A61K31/4709; A61K31/53; A61K45/06;A61K31/5377; A61K31/5383; A61K31/551; A61K31/57; A61K31/661; A61K31/16;A61K31/575; A61K31/5365; A61K31/4178; A61K31/20; A61K31/519; A61K31/541;A61K31/19; A61K31/277; A61K31/341; A61K31/36; A61K31/37; A61K31/381;A61K31/4025; A61K31/4035; A61K31/41; A61K31/415; A61K31/4196; A61K31/421;A61K31/426; A61K31/4365; A61K31/4402; A61K31/47; A61K31/473; A61K31/498;A61K31/404; A61K31/4164; A61P21/00 | Oldestpriority date: 2012-09-10 | Publication date: 2019-09-03

Score: 14.190399 | Text size: 216957 | Find: similardocuments

Heidelberg);the DIVERSet library (Chembridge Corp., San Diego, Calif.) and compounds fromthe ChemDivlibrary. ... to activate expression of the α7 integrinCompound (Obtained Commercially from ChemDiv Library)[[image:EMI-C00026]] [[image:EMI-C00027]] 1080-0573 5α-cholestan-3β- 20

USE OF ALDEHYDE DEHYDROGENASE AS BIOMARKER FOR BETA-CELL DYSFUNCTION ANDLOSS

Domenico Accili[US];Ja YoungKim-Muller [US]

Score: 11.569273 | Text size: 251540 | Find: similardocuments

Methods and compositions to treat cancer

Jeffrey Whitsett[US];Yutaka Maeda[US]

Score: 14.039395 | Text size: 70642 | Find: similardocuments

3-[2-(4-fluorobenzyl)imidazo[2,1-beta][1,3]thiazol-6-yl]-2H-chromen-2-one(iMDK) purchased from ChemDiv(San Diego, Calif.) was dissolved inDMSO.

SWEET FLAVOR MODIFIER

Score: 10.089907 | Text size: 294647 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, PA, ChemDiv of San Diego, CA, Chembridge of SanDiego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the

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COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATEACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14

TRAN, Nhan [US]; MEURICE,Nathalie [US]; DHRUV, Harshil[US];YIN, Hongwei[US]

Publicationdate: 2019-08-21 | Patent publication No.: EP-3019874-B1|Assignees: The Translational Genomics Research Institute [US] |IPC: G01N33/68; A61K31/53; A61K31/542; A61K31/4704; A61K31/541; A61K31/4188;A61K31/4192; A61K31/24; A61K45/06; A61K31/4745; A61K33/24 | Oldest priority date: 2013-09-20 | Publication date: 2019-08-21

Score: 18.245615 | Text size: 196068 | Find: similardocuments

implementedto identify virtual hits from a vendor compound library of peptidomimeticmolecules (ChemDiv, 13,637 compounds). ... The peptidomimetic setof ChemDiv (version of May 2011; 13,137 compounds) wasprepared using LigPrep version 2.5 in Schrodinger v2011 ... The peptidomimeticset of ChemDiv (13,137 compounds, v05.2011) was selected forthis study and pre-processed as described in methods. ... As shown in Figure10A, 4 compounds from the supplier ChemDiv with compoundidentifiers G873-0032, F151-0435, D715-0890, and J004-1091 showed an average... These core substructures served as query to perform a substructure searchin the ChemDiv online catalogue.

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FIBROSIS INHIBITING COMPOUNDS FOR USE IN THE PREVENTION OR TREATMENT OFFIBROSING DISEASES

GOMER, Richard,H. [US];COX, Nehemiah[US]

Publicationdate: 2019-08-21 | Patent publication No.: EP-3065548-B1|Assignees: THE TEXAS A&M UNIVERSITY SYSTEM [US] | IPC:A01N43/00; A61K31/33; A61K31/41; A61K31/425; A61K31/38; A01N37/18;A61K31/16; A61P11/06; A61P11/00; A61P1/16; A61P1/00; A61P9/00; A61P13/12;A61P17/00; A61P19/00; A61P43/00 | Oldestpriority date: 2013-09-30 | Publication date: 2019-08-21

Score: 14.165414 | Text size: 61824 | Find: similardocuments

Compound 2(Cat#545-1519) and compound 3 (Cat#4545-1530) were purchased from ChemDiv (SanDiego, CA).

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MYC G-QUADRUPLEX STABILIZING SMALL MOLECULES AND THEIR USE

SCHNEEKLOTH,John, Jr. [US]; SIMMONS, John[US];FELSENSTEIN,Kenneth [US]; MOCK, Beverly[US];SAUNDERS,Lindsey [US]; GAREISS, Peter[US];CALABRESE, David[US];LEON, Elena [US]

Publicationdate: 2019-08-21 | Patent publication No.: EP-3242661-B1|Assignees: The U.S.A. as represented by the Secretary, Department of Health and HumanServices [US]; Yale University [US] | IPC: C07D307/84; A61K31/343; A61P35/00 | Oldest priority date: 2015-01-05 | Publication date: 2019-08-21

Score: 18.078405 | Text size: 187023 | Find: similardocuments

20,000unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridgeand ChemDivscreening libraries, in addition to dyes and controls,were printed in duplicate onto four slides ... No.Peggy (% c-Myc expressioncompared to untreated)IC50 1 [[image:ib0037]] Commercial: ChemDiv No.D089-0563 50% (at 10 μM) 7.6 μM 2[[image:ib0038]] Commercial: ChemDiv No. D089-0474 72% (at 10 μM) 95%viability (at 10 μM) 3[[image:ib0039]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4[[image:ib0040]] Commercial: ChemDiv No. D089-0559 73% (at 10 μM) 75%viability (at 10 μM) 5[[image:ib0041]] Commercial: ChemBridge No.

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Methods for use in combination for the treatment and diagnosis ofautoimmune diseases

Hakon Hakonarson[US];Yun Rose Li [US]; Brendan Keating[US]

Score: 9.370946 | Text size: 364358 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Methods and Compositions for Re-activating Epstein-Barr Virus andScreening Compounds Therefor

Paul M.Lieberman [US]; NadezhdaTikhmyanova-Eckert [US]; Joseph M.Salvino [US]

Publicationdate: 2019-08-08 | Patent publication No.: US-20190240202-A1|Assignees: The Wistar Institute of Anatomy and Biology [US]; Drexel University [US] | IPC: A61K31/437;C12Q1/02; A61K45/06; A61K31/19; A61K31/69; A61K31/522; C07D471/04 | Oldest priority date:2013-08-31 | Publication date: 2019-08-08

Score: 19.037996 | Text size: 98277 | Find: similardocuments

FIG. 2B is ascatter plot of luminescence values for HTS campaign of the ChemDiv library.The well number is indicated on the X-axis. FIG. 2C is a scatter plot of datafrom HTS of ChemDiv screen (FIG. 2B) re-sorted according tothe fold induction of luminescence relative to DMSO. FIG. ... clinicalcollection, a 14,400 compound library from Maybridge, and a 50,000 compoundlibrary from ChemDiv. The Maybridge “Hit Finder” library representslead-like diversity from the larger Maybridge screening collection (56,000).The ChemDivlibrary consists of a 30,000 compound “DiscoveryChemistry” set of diverse lead-like small

Electrophysiological assays using oocytes that express human enac and theuse of phenamil to improve the effect of enac enhancers in assays usingmembrane potential reporting dyes

Guy SERVANT [US]; Hong Chang [US]; Cyril REDCROW[US];Sumita Ray [US]; lmran CLARK [US]; Bryan MOYER [US]

Score: 12.484504 | Text size: 152301 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

METHODS OF TREATING MUSCULAR DYSTROPHY

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2019-08-08 | Patent publication No.: US-20190240195-A1|Assignees: Board of Regents of the Nevada System of Higher Education, on Behalf of theUniv of Nevada, Reno [US] | IPC: A61K31/404; A61K45/06 | Oldestpriority date: 2013-03-15 | Publication date:2019-08-08

Score: 10.089907 | Text size: 347299 | Find: similardocuments

et al.,2006). 2) DIVERSet library (Chembridge Corp., San Diego, Calif.) and compoundsfrom the ChemDivlibrary. 3) LOPAC library (Sigma-RPI) consists of1280 pharmaceutically active compounds.

COMPOSITIONS AND METHODS FOR INHIBITING GROUP II INTRON RNA

PYLE, Anna [US]; FEDOROVA, Olga[US];JAGDMANN, Erik,Gunnar [US];VAN ZANDT,Michael [US]; YUAN, Lin [US]; DeBERARDINIS,Albert [US]

Score: 10.089907 | Text size: 282266 | Find: similardocuments

(76compounds), protease inhibitors (53 compounds) and additional compounds fromChemBridge MW andChemDiv to bring the total number of compounds to10000. The D135 ribozyme (Su et al.

Methods for treatment of retinal disease by photoreceptor gene expressionmodulation

Thomas A. Reh[US];Paul Nakamura[US];Sheng Ding [US]

Publicationdate: 2019-07-30 | Patent publication No.: US-10363256-B2|Assignees: University of Washington [US]; The J. David Gladstone Institutes, aTestamentary Trust Established Under the Will of J. David Gladstone [US] | IPC: A61K9/00;A61P27/02; A61K31/426; A61K31/519; C07D495/04 | Oldest priority date: 2015-03-27 | Publication date: 2019-07-30

Score: 18.390413 | Text size: 64233 | Find: similardocuments

(I) isCA8801: [[image:EMI-C00006]] Compounds CA88 and CA8801 are commercially availablefrom ChemDiv(San Diego, Calif. ... (II) is CA9513:[[image:EMI-C00010]] Compounds CA95 and CA9513 are commercially availablefrom ChemDiv (San Diego, Calif. ... Nr2e3 interactingmolecules specifically identified herein were obtained commercially from ChemDiv (SanDiego, Calif.

Methods for identifying subjects with a genetic risk for developing IgAnephropathy

Ali Gharavi [US]; KrzysztofKiryluk [US]; Richard Lifton[US]

Publicationdate: 2019-07-23 | Patent publication No.: US-10358678-B2|Assignees: The Trustees of Columbia University in the City of New York [US]; YaleUniversity [US] | IPC: C12Q1/6883 | Oldestpriority date: 2011-02-17 | Publication date: 2019-07-23

Score: 12.484504 | Text size: 190979 | Find: similardocuments

(A divisionof Key Organics Limited), Camelford, UK; ChemBridge Corporation, San Diego,Calif.; ChemDiv Inc., San Diego, Calif.; ChemRx AdvancedTechnologies, South San Francisco, Calif.; ComGenex Inc.

Small molecule inhibitors of influenza A RNA-dependent RNA polymerase

Kayvan Niazi[US];ShahroozRabizadeh [US]; Anne-Laure Le Ny[US];Oleksandr Buzko[US];Justin Golovato[US];PatrickSoon-Shiong [US]

Publicationdate: 2019-07-16 | Patent publication No.: US-10350225-B1|Assignees: Nant Holdings IP, LLC [US] | IPC: C07D417/12; A61K31/635; A61K31/55; A61K31/501; A61K31/5377; A61K31/47;A61K31/4409; A61K31/4709; A61K31/496; A61K31/4545; A61K31/444; A61K31/426;A61K31/454; G16B5/00 | Oldestpriority date: 2013-01-31 | Publication date: 2019-07-16

Score: 14.692947 | Text size: 57917 | Find: similardocuments

(ChemDiv,

METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITIONCONTAINING STABILIZED SWEET ENHANCER

CatherineTachdjian [US]; DonaldKaranewsky [US]; Xiao Qing Tang[US];Hanghui Liu [US]

Score: 8.557886 | Text size: 449476 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

COMPOUNDS AND METHODS FOR TREATING OR PREVENTING ANTERIOR SEGMENT OCULARDISORDERS AND/OR RETINAL DEGENERATIONS

FIELDS, Mark[US];DEL PRIORE,Lucian [US];CAI, Huey [US]; HOYER, Denton[US]

Score: 16.402758 | Text size: 100248 | Find: similardocuments

As usedherein,“compound 414” or“YU 162779-01” refers to ChemDiv librarycompound number C325-0414, or a salt, solvate or hydrate thereof, having theformula: [[image:imgf000013_0001]] As used herein,“compound 434”or“YU162787-01” refers to ChemDiv library compound numberC325-0434, or a salt, solvate or hydrate thereof, having the

Soluble CD33 for treating myelodysplastic syndromes (MDS)

Alan F. List[US];Sheng Wei [US]

Publicationdate: 2019-07-09 | Patent publication No.: US-10344072-B2|Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc. [US] | IPC: A61K38/17;C07K19/00; C07K14/705; A61K47/00; A61K47/50; G01N33/68; A61K47/69; C07K14/735;A61K38/00 | Oldestpriority date: 2013-07-05 | Publication date: 2019-07-09

Score: 11.918776 | Text size: 178331 | Find: similardocuments

Corporation(16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA,www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, SanDiego, Calif.

COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, ANDTREATMENT OF AML USING USP10 BIOMARKERS AND MODULATORS

Sara Buhrlage[US];Ellen Weisberg[US];James D. Griffin[US]

Publicationdate: 2019-07-04 | Patent publication No.: US-20190202929-A1|Assignees: Sara BUHRLAGE [US]; Ellen WEISBERG [US]; James Douglas GRIFFIN [US];Dana-Farber Cancer Institute, Inc. [US] | IPC: C07K16/30;C12Q1/686; C12Q1/6806; A61P35/02; C12Q1/02; C12Q1/6841; C12Q1/6851; A01K67/027|Oldestpriority date: 2016-09-20 | Publication date: 2019-07-04

Score: 7.874651 | Text size: 455531 | Find: similardocuments

HBX19818analogs were purchased from ChemDiv and dissolved in DMSO toobtain a 10 mM stock solution.

ALPHA- AND GAMMA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICALCOMPOSITIONS THEREOF

Iwao Ojima [US]; Dale Deutsch[US];Martin Kaczocha[US];William T.Berger [US];Robert Rizzo[US];Trent E. Balius[US]

Publicationdate: 2019-07-04 | Patent publication No.: US-20190201365-A1|Assignees: The Research Foundation for The State University of New York [US] | IPC: A61K31/216;C07C69/76; A61K31/194; G01N33/68; C07C67/08; C07C211/58; C07C69/757;C07C69/753; G01N33/566; C07C67/48; C07C235/40; C07C235/38; C07C233/58;C07C233/11 | Oldestpriority date: 2012-07-20 | Publication date: 2019-07-04

Score: 19.91218 | Text size: 140509 | Find: similardocuments

EnergeticallyDOCK selected ligands from the ChemDiv library that did nothave unfavorable interaction, both VDW and ES, intrinsically selecting ... The followingcompounds are available from ChemDiv (San Diego, Calif., USA):StructureChemDiv ID Number [[image:EMI-C00036]] 8009-2334[[image:EMI-C00037]] 8009-3434 [[image:EMI-C00038]] ... acid was from CaymanChemical (Ann Arbor, Mich.). 48 virtually screened test compounds from ChemDiv,Inc. (Moscow, Russia). ... Competitors included arachidonic acid,BMS309403, 48 test compounds from ChemDiv library, Compound 26and Compound 49. ... Virtual Screening A high-throughput virtual screening ofover one million molecules from the ChemDiv subset of the ZINCdatabase (http://zinc.docking.

USE OF IMIDAZOPYRIMIDINE FOR MODULATING HUMAN IMMUNE RESPONSE

LEVY, Ofer [US]; DOWLING, DavidJ. [US];BORRIELLO,Francesco [US]; SCOTT, David A.[US];BRIGHTMAN,Spencer E. [US]; FERU, Frederic[US]

Publicationdate: 2019-05-23 | Patent publication No.: WO-2019099578-A1|Assignees: CHIDREN'S MEDICAL CENTER CORPORATION [US]; DANA-FARBER CANCER INSTITUTE,INC. [US] | IPC: A61K31/52; C07D473/32 | Oldestpriority date: 2017-11-14 | Publication date: 2019-05-23

Score: 13.4640045 | Text size: 324834 | Find: similardocuments

bioactiveand commercial libraries from various sources including commercial librariessuch as ChemDiv, ChemBridge, and Asinex (see attached pdf of alllibraries). ... known bioactive and commercial libraries from various sources (e.g.,commercial libraries such as ChemDiv, ChemBridge, and Asinex; seeattached pdf of all libraries).

NOVEL IMIDAZOPYRIMIDINE COMPOUNDS AND USES THEREOF

LEVY, Ofer [US]; DOWLING, DavidJ. [US];BORRIELLO,Francesco [US]; SCOTT, David, A[US];BRIGHTMAN,Spencer E. [US]; FERU, Frederic[US]

Publicationdate: 2019-05-23 | Patent publication No.: WO-2019099564-A1|Assignees: CHILDREN'S MEDICAL CENTER CORPORATION [US]; DANA-FARBER CANCER INSTITUTE,INC. [US] | IPC: A61K31/4188; A61K31/519; C07D487/04; A61P37/02 | Oldest priority date: 2017-11-14 |Publicationdate: 2019-05-23

Score: 13.4640045 | Text size: 269157 | Find: similardocuments

bioactiveand commercial libraries from various sources including commercial librariessuch as ChemDiv, ChemBridge, and Asinex (see attached pdf of alllibraries). ... known bioactive and commercial libraries from various sources(e.g., commercial libraries such as ChemDiv, ChemBridge, andAsinex; see attached pdf of all libraries).

IDENTIFICATION OF NOVEL LOCI IN ASTHMA AND METHODS OF USE THEREOF FOR THEDIAGNOSIS AND TREATMENT OF ASTHMA

Hakon Hakonarson[US];Berta Almogurea[US];Lyam M. Vasquex[US];Patrick M.a.Sleiman [US]

Publicationdate: 2019-05-23 | Patent publication No.: US-20190153523-A1|Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US] | IPC: C12Q1/6827;C12Q1/6883; A61K45/06; A61P11/06 | Oldestpriority date: 2016-07-21 | Publication date: 2019-05-23

Score: 12.484504 | Text size: 171594 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

USING MICRORNAS TO CONTROL ACTIVATION STATUS OF HEPATIC STELLATE CELLSAND TO PREVENT FIBROSIS IN PROGRESSIVE LIVER DISEASES

Michael YoonsukCHOI [US];Byeong-Moo KIM[US]

Score: 11.569273 | Text size: 199903 | Find: similardocuments

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive ChemistryLtdTM, ChemDiv, ChemBridgeTM, TimTec IncTM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.

ISL1-Based Gene Therapy to Treat Hearing Loss

Zheng-Yi Chen[US];Yujuan Ju [US]

Score: 12.484504 | Text size: 137874 | Find: similardocuments

availablecompound libraries (suppliers include Chembridge Corp (San Diego, Calif.)and ChemDiv (San Diego, Calif.)).

COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS

HOON, Mark A.[US];SOLINSKI, HansJuergen [DE]; INGLESE, James[US];DRANCHAK,Patricia [US]; HOON, Mark A.[US];SOLINSKI, HansJuergen [DE]; INGLESE, James[US];DRANCHAK,Patricia [US]

Publicationdate: 2019-05-09 | Patent publication No.: WO-2019090039-A1|Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENTOF HEALTH AND HUMAN SERVICES [US] | IPC: A61K31/422; A61K31/4184; A61K31/015; A61K31/42; A61K31/437; A61K31/439;A61K31/4545; A61K31/4985; A61K31/506; A61K31/519; A61K31/55; A61K31/5513;A61K31/5517; A61P17/04; A61P43/00 | Oldestpriority date: 2017-11-03 | Publication date: 2019-05-09

Score: 18.04004 | Text size: 92160 | Find: similardocuments

a][l,4]diazepine-4,4'-piperidin]-r-yl)methanone(Chemdiv Inc., catalog number S217-0244); (m)N-benzyl-l-(2-cyanobenzyl)-4-oxo-l ,5-diazacycloundecane-8-carboxamide (ChemdivInc., catalog number S733-0866); or (n)N-benzyl-N-methyl-8-phenylimidazo[l,2-a]pyrazine-2-carboxamide (Chemdiv Inc.,catalog number T425-0460).

ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME

Dan THEODORESCU[US];MichaelFitzpatrick WEMPE [US]; David ROSS [US]; Chao YAN [US]; Phillip REIGAN[US]

Publicationdate: 2019-05-09 | Patent publication No.: US-20190135824-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate [US] | IPC: C07D491/052;A61K31/4162; A61K45/06 | Oldestpriority date: 2014-07-10 | Publication date: 2019-05-09

Score: 12.290053 | Text size: 139037 | Find: similardocuments

The ChemDiv library[v2006.

COMPOSITIONS AND METHODS FOR THE INHIBITION OF PRURITUS

Mark A. Hoon[US];Hans JuergenSolinski [DE]; James Inglese[US];PatriciaDranchak [US]

Publicationdate: 2019-05-09 | Patent publication No.: US-20190135804-A1|Assignees: The United States of America,as represented by the Secretary,Department ofHealth and Human Services [US] | IPC: C07D471/04; C07D487/04; C07D413/12; A61P17/04 | Oldest priority date: 2017-11-03 | Publication date: 2019-05-09

Score: 18.248644 | Text size: 72732 | Find: similardocuments

(ChemdivInc., catalog number S217-0244); (m)N-benzyl-1-(2-cyanobenzyl)-4-oxo-1,5-diazacycloundecane-8-carboxamide (ChemdivInc., catalog number S733-0866); or (n)N-benzyl-N-methyl-8-phenylimidazo[1,2-a]pyrazine-2-carboxamide (Chemdiv Inc.,catalog number T425-0460).

SMALL MOLECULE INHIBITORS OF CANCER STEM CELLS AND MESENCHYMAL CANCERTYPES

LAIRSON, Luke L.[US];BOLLONG, MichaelJ. [US];SCHULTZ, PeterG. [US];MANI, SenduraiA. [US]

Publicationdate: 2019-05-09 | Patent publication No.: WO-2019089577-A1|Assignees: THE SCRIPPS RESEARCH INSTITUTE [US]; BOARD OF REGENTS, THE UNIVERSITY OFTEXAS SYSTEM [US] | IPC: A61K31/437; A61K31/4704; A61K31/4741; A61K31/497; A61K31/498; A61K31/4985;A61K31/502; A61K31/551; A61P35/04 | Oldestpriority date: 2017-10-30 | Publication date: 2019-05-09

Score: 16.930674 | Text size: 99538 | Find: similardocuments

Selected hitcompounds were reordered from ChemDiv and tested for selectivetoxicity in 10-point response assays as above. ... a library of -50,000 diverseheterocyclic compounds and biologically active small molecules (ChemDiv,San Diego, CA, USA) for cytotoxic activity against both cell lines, [00139] Preliminaryscreening

METHODS AND COMPOSITIONS TO TREAT CANCER

Jeffrey A.Whitsett [US]; Yutaka Maeda[US];Takuya Fukazawa[JP]

Publicationdate: 2019-05-09 | Patent publication No.: US-20190134053-A1|Assignees: Takuya FUKAZAWA [JP]; Children's Hospital Medical Center [US] | IPC: A61K31/5377;A61K31/429; A61K31/444; A61K31/4375; A61P35/00 | Oldest priority date: 2016-07-28 | Publication date:2019-05-09

Score: 14.557414 | Text size: 46365 | Find: similardocuments

(hereinafter “iMDK” (Compound A, below) was purchased from ChemDiv (SanDiego, Calif.

Methods to identify modulators of RyR calcium channels

Razvan L. Cornea[US];Donald M. Bers[US];David D. Thomas[US];Gregory D.Gillispie [US]

Score: 12.290053 | Text size: 179884 | Find: similardocuments

and includeAMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridgeLibrary, ChemDivLibrary, Enamine Library, The Greenpharma NaturalCompound Library, Life Chemicals Library,

NON-BETA LACTAM ANTIBIOTICS

Mayland CHANG[US];ShahriarMobashery [US]; Edward Spink[GB];Derong Ding [US]; SebastianTestero [AR]; Erika Leemans[BE];Marc Boudreau[US]

Publicationdate: 2019-05-02 | Patent publication No.: US-20190127340-A1|Assignees: University Of Notre Dame Du Lac [US] | IPC:C07D271/107; C07D413/04; C07F9/653; C07D471/04 | Oldest priority date: 2014-09-25 | Publication date: 2019-05-02

Score: 14.999643 | Text size: 177982 | Find: similardocuments

A library of1.2 million drug-like compounds from the ChemDiv subset of theZINC database (Irwin et al., J. Chem. Inf. Model. ... From these, 29 compoundswere selected and purchased from ChemDiv for in vitro activityexperiments. Syntheses.

Isolated human lung progenitor cells and uses thereof

JayarajRajagopal [US]; Hongmei Mou [US]

Publicationdate: 2019-04-30 | Patent publication No.: US-10273450-B2|Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC:C12N5/074; A61K35/42; A61L27/38; A61L27/56; A61L27/58; G01N33/68;C12N5/071; A61K9/00 | Oldestpriority date: 2012-01-13 |Publicationdate: 2019-04-30

Score: 9.838301 | Text size: 266887 | Find: similardocuments

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM Exclusive ChemistryLtd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.

Subunit selective NMDA receptor potentiators for the treatment ofneurological conditions

Stephen F.Traynelis [US]; Dennis C. Liotta[US];Rose M.Santangelo [US]; Ethel C. Garnier[US]

Publicationdate: 2019-04-30 | Patent publication No.: US-10273214-B2|Assignees: Emory University [US] | IPC: C07D217/16; C07D491/056; C07D409/06; C07D405/06; C07D401/06; C07D413/06;C07D409/04; C07D401/04; C07D277/34; C07D263/58; C07D239/88; C07D215/22;C07D209/08 | Oldestpriority date: 2009-01-28 | Publication date: 2019-04-30

Score: 16.882145 | Text size: 168432 | Find: similardocuments

molecules,such as beta-turn mimetic libraries and the like, may be purchased from forexample ChemDiv, Pharmacopia or Combichem or synthesized and aredescribed in Tietze and Lieb, Curr. Opin. Chem. ... For example, ChemDiv usesmore than 800 individual chemical cores, a unique Building Block Library, andproprietary ... In addition, ChemDiv's compounds are designed toensure their similarity to drugs adjusted according to proprietary

Screening methods for the binding affinity of chemical entities tobiological molecules and NEDD4-1 inhibitors identified by the screening methods

Alexander V.Statsyuk [US]; Stefan G.Kathman [US]

Publicationdate: 2019-04-30 | Patent publication No.: US-10273208-B2|Assignees: Northwestern University [US] | IPC: G01N33/68; H01J49/00; H01J49/16; C07C235/40; C07D209/42; C07D231/56;C07D307/84; C07D471/04 | Oldestpriority date: 2014-05-23 | Publication date: 2019-04-30

Score: 11.918776 | Text size: 196210 | Find: similardocuments

fromAccelrys, 94,275 commercially available carboxylic acids were identified fromthe ChemBridge, ChemDiv, MayBridge, NCI and Sigma-Aldrich librariesusing SMARTS query strings.

Methods of treating muscular dystrophy

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2019-04-30 | Patent publication No.: US-10272069-B2|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THEUNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/40; A01N43/38; A61K31/404; A61K45/06 | Oldest priority date: 2012-09-10 | Publication date: 2019-04-30

Score: 14.450268 | Text size: 238806 | Find: similardocuments

Heidelberg);the DIVERSet library (Chembridge Corp., San Diego, Calif.) and compounds fromthe ChemDivlibrary. ... α7 integrin Compound (ObtainedIncreased A7 Expression Commercially from Myotubes + MyoblastsChemDiv Library)EC100 Myoblasts Only 5α-cholestan-3β-ol-6-oneN032-0003 N066-0070 N069-0071 N069-0075

TAF1 INHIBITORS FOR THE THERAPY OF CANCER

Sara SDELCI [AT]; Stefan KUBICEK[AT]

Publicationdate: 2019-04-25 | Patent publication No.: US-20190117641-A1|Assignees: CeMM - Forschungszentrum für Molekulare Medizin GmbH [AT] | IPC: A61K31/4725;A61P35/00; A61K31/22; A61K31/517; A61K31/5517 | Oldest priority date: 2016-02-15 | Publication date: 2019-04-25

Score: 10.354719 | Text size: 235623 | Find: similardocuments

CompoundsA2, A3, A4 and A5 were purchased from ChemDiv (San Diego,USA). Synthesis of all other analogs was carried out by Enamine Ltd.

MITOFUSIN ACTIVATORS AND USES THEREOF

GAVATHIOTIS,Evripidis [US]; KITSIS, Richard,N. [US];BIRIS, Nikolaos[US];ZACHARIOUDAKIS,Emmanouil [US]

Score: 14.293713 | Text size: 58596 | Find: similardocuments

ScreenedMASMs were purchased from Enamine, ChemBridge and ChemDiv.

Plasmodial surface anion channel inhibitors for the treatment orprevention of malaria

Sanjay A. Desai[US]

Publicationdate: 2019-04-23 | Patent publication No.: US-10265313-B2|Assignees: The United States of America, as represented by the Secretary, Departmentof Health and Human Services [US] | IPC: A61K31/4985; A61K31/501; A61K31/496; C07D413/14; C07D409/04; C07D409/14;C07D239/84; C07D417/06; C07D241/44; C07D263/57; C07D491/048; C07D498/04;C07D277/54; C07D513/04; C07D281/16; A61K31/42; A61K31/433; A61K31/495;A61K31/498; A61K31/50; A61K31/519; A61K31/554; C07K14/445; A61K31/422;A61K31/4741; A61K31/517; A61K39/015; C07K16/20; A61K45/06; A61K31/423;A61K31/427; A61K31/4355; A61K31/437; A61K31/4439 | Oldest priority date:2011-04-12 | Publication date: 2019-04-23

Score: 15.906768 | Text size: 142600 | Find: similardocuments

methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, Calif. or Peakdale MolecularLimited, High Peak, England. ... room temperature using a commercial library of50,000 compounds with >90% purity confirmed by NMR (ChemDiv). Screenswere performed in 384-well format with individual wells containing a singlecompound at

Complement C3d-binding compounds

DimitriosMorikis [US]; Ronald D.Gorham, Jr. [US]

Publicationdate: 2019-04-16 | Patent publication No.: US-10259824-B2|Assignees: The Regents of the University of California [US] | IPC:C07D495/04; C07D249/04; C07D417/14; C07D471/04; A61P27/02; A61K31/165 | Oldest priority date: 2015-05-01 | Publication date: 2019-04-16

Score: 13.793969 | Text size: 93675 | Find: similardocuments

Selecteddrug-like compounds were obtained from Enamine, Pharmeks, ChemDiv,ChemBridge, and Maybridge.

TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

Steven AlbertEverett [US]; Saraj Ulhaq [GB]

Publicationdate: 2019-02-28 | Patent publication No.: US-20190060472-A1|Assignees: University Court of the University of Dundee [GB] | IPC: A61K47/54;C07D491/22; A61K31/513; C07D417/12; C07D409/12; C07D407/12; C07D405/14;C07D405/12; C07D405/04; C07D311/18; C07D311/16; C07D307/80; A61K31/664;A61K31/428; A61K31/4184; A61K31/352; A61K31/343; A61K31/52; A61K31/665;A61K31/37; A61K31/381; C07D487/04 | Oldestpriority date: 2009-05-01 | Publication date: 2019-02-28

Score: 16.189404 | Text size: 219848 | Find: similardocuments

for CYP1B1The target enzyme CYP1B1 was screened against two commercial librariesincluding the ChemDivDiversity 50,000 test compound collection andthe ChemDiv Kinase Targeted 10,000 test compound collectionwith a view to identifying activity differentiating ... cross validation on atraining set selected from 45,000 and 9,000 test compounds from the ChemDiv Diverseand Kinase libraries.

STRUCTURE OF PLASMEPSIN V IN COMPLEX WITH AN INHIBITOR AND USES THEREOF

Justin BODDEY[AU];Alan COWMAN [AU]; Peter CZABOTAR[AU];Tony HODDER [AU]; Brad SLEEBS [AU]

Score: 7.2924438 | Text size: 927233 | Find: similardocuments

from, forexample, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest,Hungary) and ChemDiv(San Diego, Calif.), Specs (Delft, The Netherlands).

Electrophysiological assays using oocytes that express human ENaC and theuse of phenamil to improve the effect of ENaC enhancers in assays usingmembrane potential reporting dyes

Guy Servant [US]; Hong Chang [US]; Cyril Redcrow[US];Sumita Ray [US]; Imran Clark [US]; Bryan Moyer [US]

Score: 12.484504 | Text size: 153665 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

α- and γ-truxillic acid derivatives and pharmaceuticalcompositions thereof

Iwao Ojima [US]; Dale Deutsch[US];Martin Kaczocha[US];William T.Berger [US];Robert Rizzo[US];Trent E. Balius[US]

Publicationdate: 2019-02-26 | Patent publication No.: US-10213406-B2|Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK [US] | IPC: A61K31/216;C07C67/08; C07C211/58; C07C233/11; C07C233/58; C07C235/38; C07C235/40;C07C69/753; C07C69/76; C07C67/48; C07C69/757; G01N33/566; A61K31/194; G01N33/68|Oldestpriority date: 2012-07-20 | Publication date: 2019-02-26

Score: 19.91218 | Text size: 149952 | Find: similardocuments

EnergeticallyDOCK selected ligands from the ChemDiv library that did nothave unfavorable interaction, both VDW and ES, intrinsically selecting ... Thefollowing compounds are available from ChemDiv (San Diego,Calif., USA): StructureChemDiv ID Number [[image:EMI-C00036]] 8009-2334[[image:EMI-C00037]] 8009-3434 [[image:EMI-C00038]] ... acid was from CaymanChemical (Ann Arbor, Mich.). 48 virtually screened test compounds from ChemDiv,Inc. (Moscow, Russia). ... Competitors included arachidonic acid,BMS309403, 48 test compounds from ChemDiv library, Compound 26and Compound 49. ... Virtual Screening A high-throughput virtual screening ofover one million molecules from the ChemDiv subset of the ZINCdatabase (http://zinc.docking.

SMALL MOLECULE INHIBITORS OF PENDRIN ION EXCHANGE AND PHARMACEUTICALCOMPOSITIONS

Alan S. VERKMAN[US];Peter M. HAGGIE[US];Onur CIL [US]

Publicationdate: 2019-02-21 | Patent publication No.: US-20190054071-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/437;A61P31/04; A61P31/12; A61P11/00 | Oldestpriority date: 2016-02-26 | Publication date: 2019-02-21

Score: 16.234026 | Text size: 92083 | Find: similardocuments

Screeningwas done with ̃36,000 compounds from ChemDiv (San Diego,Calif.), TimTec (Newark, Del. ... PDSinh-C01 was purchased from ChemDiv (SanDiego Calif., USA). Other chemicals were purchased from Sigma unless otherwisestated.

Eis inhibitors

SylvieGarneau-Tsodikova [US]; Oleg V. Tsodikov[US];James E. Posey[US]

Publicationdate: 2019-02-19 | Patent publication No.: US-10208000-B2|Assignees: University of Kentucky Research Foundation [US] |IPC: C07D241/44; A61K31/498; A61K31/7036; A61K45/06 | Oldest priority date: 2015-12-16 | Publication date: 2019-02-19

Score: 18.946571 | Text size: 151048 | Find: similardocuments

Compoundswere retested as fresh powder samples purchased from ChemDiv. ...Center for Chemical Genomics (CCG, University of Michigan) against 123,000compounds from (i) a ChemDiv library (120,000), (ii) theBioFocus NCC library, and (iii) the MicroSource MS2000 library. ... or triagefalse positives were performed with hit compounds from fresh powders purchasedfrom ChemDiv (San Diego, Calif., USA). ... Center for ChemicalGenomics (CCG, University of Michigan) against 123,000 compounds from (i)a ChemDiv library (120,000), (ii) the BioFocus NCC library,and (iii) the MicroSource MS2000 library. ... The activity of promisingcompounds was confirmed using fresh powder samples purchased from ChemDiv (SanDiego, Calif., USA). Note: All concentrations noted below are finalconcentration.

Methods, systems, and devices for an invertebrate model of traumaticbrain injury

Barry S.Ganetzky [US]; David A.Wassarman [US]

Score: 14.293713 | Text size: 88506 | Find: similardocuments

DiscoverySystems, Inc. (Gaylordsville, Conn.); ChemBridge Corporation (San Diego,Calif.); and ChemDiv Inc.(San Diego, Calif.

Methods of treating muscular dystrophy

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2019-02-19 | Patent publication No.: US-10206903-B2|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THEUNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/404; A61K45/06 | Oldestpriority date: 2013-03-15 | Publication date: 2019-02-19

Score: 10.089907 | Text size: 367348 | Find: similardocuments

et al.,2006). 2) DIVERSet library (Chembridge Corp., San Diego, Calif.) and compoundsfrom the ChemDivlibrary. 3) LOPAC library (Sigma-RPI) consists of1280 pharmaceutically active compounds.

COMPOSITIONS AND METHODS OF TREATMENT USING NICOTINAMIDE MONONUCLEOTIDE

IMAI,Shin-Ichiro [US]; GROZIO, Alessia[US]

Score: 11.918776 | Text size: 164006 | Find: similardocuments

media contending0.2% DMSO (vehicle), 20μΜ EX527(Cayman chemical, MI) or 20μΜ STK665401 (ChemDiv, cat #8018-9378;Sociali, G. et al., Eur. J. Med. Chem., 2015, 102, 530-539).

PHOTORECEPTOR GENE MODULATOR PHOTOREGULIN 3 FOR TREATMENT OF RETINALDISEASE

REH, Thomas, A.[US];NAKAMURA, Paul[US];SHIMCHUK, Andy[US];TANG, Shibing[CN];DING, Sheng [US]

Publicationdate: 2019-02-14 | Patent publication No.: WO-2019032999-A1|Assignees: UNIVERSITY OF WASHINGTON [US]; THE J. DAVID GLADSTONE INSTITUTES [US] | IPC: A61K31/426;A61K31/519; A61K9/00 | Oldestpriority date: 2017-08-10 | Publication date: 2019-02-14

Score: 14.971729 | Text size: 41868 | Find: similardocuments

It wasinitially obtained from ChemDiv and then synthesized andpurified in large quantities in the lab after initial screening.

PROTEOSTASIS REGULATORS

FOLEY, Megan[US];TAIT, Bradley[US];CULLEN, Matthew[US]

Score: 12.685205 | Text size: 128793 | Find: similar documents

Compound A47(also shown below) was purchased from ChemDiv, San Diego, CA.

External link

Anti-cancer compounds targeting Ral GTPases and methods of using the same

Dan Theodorescu[US];MichaelFitzpatrick Wempe [US]; David Ross [US]; Chao Yan [US]; Phillip Reigan[US]

Publicationdate: 2019-02-12 | Patent publication No.: US-10202397-B2|Assignees: The Regents of the University of Colorado, a body corporate [US] | IPC: C07D491/052;A61K31/4162; A61K45/06 | Oldestpriority date: 2014-07-10 | Publication date: 2019-02-12

Score: 12.290053 | Text size: 154638 | Find: similardocuments

The ChemDiv library[v2006.

MYC G-quadruplex stabilizing small molecules and their use

JohnSchneekloth, Jr. [US]; John Simmons[US];KennethFelsenstein [US]; Beverly Mock[US];Lindsey Saunders[US];Peter Gareiss[US];David Calabrese[US];Elena Leon [US]

Publicationdate: 2019-02-05 | Patent publication No.: US-10196372-B2|Assignees: The United States of America, as represented by the Secretary, Departmentof Health and Human Services [US]; Yale University [US] | IPC: C07D307/84;A61K31/343; A61K31/397; A61K31/4025; A61K31/439; A61K31/4525; A61K31/496;A61K31/5377; A61K31/55; A61K45/06; C07D405/06; C07D471/08 | Oldest priority date: 2015-01-05 |Publicationdate: 2019-02-05

Score: 18.078405 | Text size: 187752 | Find: similardocuments

20,000unique small molecule stock solutions (10 mM in DMSO) purchased from ChemBridgeand ChemDivscreening libraries, in addition to dyes and controls,were printed in duplicate onto four slides ... No.Peggy (% c-Myc expressioncompared to untreated) IC50 1 [[image:EMI-C00030]] Commercial: ChemDiv No.D089-0563 50% (at 10 μM) 7.6 μM 2[[image:EMI-C00031]] Commercial: ChemDiv No. D089-0474 72% (at10 μM) 95%viability (at 10 μM) 3[[image:EMI-C00032]] Commercial: Otava Chemical No. 7018860541 52% (at 10 μM) 6.3 μM 4[[image:EMI-C00033]] Commercial: ChemDiv No. ... ChemBridgeNo. 6238398 69% (at 10 μM) 89%viability (at 10 μM) 12[[image:EMI-C00041]] Commercial: ChemDiv No. D089-0350 43% (at10 μM) 3.4 μM 13[[image:EMI-C00042]] Commercial: Otava Chemical No.

CFTR REGULATORS AND METHODS OF USE THEREOF

Alan S. Verkman[US];Marc H. Levin[US];Onur Cil [US]; Mark J. Kurth[US]

Publicationdate: 2019-01-31 | Patent publication No.: US-20190031622-A1|Assignees: The Regents of the University of California [US] |IPC: C07D241/44; C07D401/06; C07D405/06; C07D409/06 | Oldest priority date: 2015-12-24 | Publication date: 2019-01-31

Score: 14.70854 | Text size: 764675 | Find: similardocuments

was doneusing a diverse collection of 120,000 drug-like synthetic compounds obtainedfrom ChemDiv Inc.(San Diego, Calif., USA) and Asinex (Winston-Salem,N.C., USA). For structure-activity analysis, 600 commercially available analogs(ChemDiv Inc.) of active compounds identified in the primary screen weretested. ... was done using a diverse collection of 120,000 drug-like syntheticcompounds obtained from ChemDiv Inc. (San Diego, Calif., USA)and Asinex (Winston-Salem, N.C., USA). For structure-activity analysis, 600commercially available analogs (ChemDiv Inc.) of active compoundsidentified in the primary screen were tested.

CFTR REGULATORS AND METHODS OF USE THEREOF

Alan S. Verkman[US];Marc H. Levin[US];Onur Cil [US]

Publicationdate: 2019-01-31 | Patent publication No.: US-20190031630-A1|Assignees: The Regents of the University of California [US] |IPC: C07D285/135; C07D417/12; A61P1/10; A61P27/04 | Oldest priority date: 2015-12-24 | Publication date: 2019-01-31

Score: 15.53077 | Text size: 433087 | Find: similardocuments

was doneusing a diverse collection of 120,000 drug-like synthetic compounds obtainedfrom ChemDiv Inc.(San Diego, Calif., USA) and Asinex(Winston-Salem, N.C., USA). For structure-activity analysis, 600 commerciallyavailable analogs (ChemDiv Inc.) of active compounds identified in theprimary screen were tested. ... was done using a diverse collection of 120,000drug-like synthetic compounds obtained from ChemDiv Inc. (SanDiego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). Forstructure-activity analysis, 600 commercially available analogs (ChemDivInc.) of active compounds identified in the primary screen were tested.

NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI ORSWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF

TACHDJIAN,Catherine [US]; PATRON, Andrew,P. [US];ADAMSKI-WERNER,Sara, L. [US]; BAKIR, Farid[US];CHEN, Qing [US]; DARMOHUSODO,Vincent [US]; ROGERS, Daniel,Harry [US];LI, Xiadong [US]; QI, Ming, CaiLun Lu [CN];ROGERS, Daniel,Harry [US];RINNOVA, Marketa[US];SERVANT, Guy[US];TANG, Xiao-Qing[US];ZOLLER, Mark[US];WALLACE, Mark[US];XING, Amy [US]; GUBERNATOR,Klaus [US]

Publicationdate: 2019-01-23 | Patent publication No.: EP-3431464-A2|Assignees: Senomyx Inc. [US] | IPC: C07C275/30; C07C275/34; C07C233/65; C07C235/54; C07D317/68; C07D307/84;G01N33/566; G01N33/74; C07D307/34; C07D333/02; C07D221/00; C07D247/00; C07D261/00;C07D283/00; A23L27/20 | Oldestpriority date: 2004-03-09 | Publication date: 2019-01-23

Score: 7.874651 | Text size: 425415 | Find: similar documents

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia PA, ChemDiv of San Diego CA, Chembridge of SanDiego CA, Asinex of Moscow Russia, SPECS/BIOSPECS of the

External link

Anti-depression compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]; Jeffrey M.Zigman [US]

Publicationdate: 2019-01-22 | Patent publication No.: US-10183011-B2|Assignees: Board of Regents of The University of Texas System [US] | IPC: A61K31/4045;C07D209/04; C07D209/82; C07D401/06; C07D413/06; C07D471/04; C07D403/12;C07D403/06; C07F5/02; C07D487/04; A61K31/44; A61K31/403; A61K31/4439;A61K31/404; A61K31/4155; A61K31/4192; A61K31/422; A61K31/437; A61K31/4425;A61K31/506; C07D413/14; C07D401/12; C07D403/14; C07D407/06; C07D209/88;C07D405/12; C07D495/04; C07D209/08; C07D209/86; C07F7/08; A61K31/4188;A61K31/41; A61K31/429; A61K31/5377; A61K31/69 | Oldest priority date: 2009-01-09 | Publication date: 2019-01-22

Score: 17.703602 | Text size: 787374 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 60.1-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00139]] This compound can be purchased from ChemDiv, Inc.Example61. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00140]] This compound can be purchased from ChemDiv, Inc. Example62. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00141]] This compound can be purchased from ChemDiv, Inc. Example63. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00142]] This compound can be purchased from ChemDiv, Inc. Example64.

FLY AVATARS FOR CANCER AND USES THEREOF

Ross Cagan [US]; Erdem Bangi [US]

Publicationdate: 2019-01-10 | Patent publication No.: US-20190011435-A1|Assignees: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US] | IPC: G01N33/50;A61K31/519; A61K31/405; A01K67/033 | Oldestpriority date: 2015-12-30 | Publication date: 2019-01-10

Score: 15.970954 | Text size: 228933 | Find: similardocuments

CompoundLibrary MedChem Express MAPK Compound Library MedChem Express Akt-TargetedLibraryChemDiv PI3K-Targeted Library ChemDiv KRAS-TargetedLibrary ChemDiv EXPRESS-Pick Collection ChemBridge DIVERSetTM-EXP ChemBridge CORE Library ChemBridge DIVERSet

YEAST CELLS EXPRESSING TAR DNA-BINDING PROTEIN 43 AND USES THEREFOR

Susan L.Lindquist [US]; Aaron D. Gitler[US]

Score: 14.039395 | Text size: 75222 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

MEANS AND METHODS FOR IDENTIFYING RIBOSOME ASSOCIATED RNA MOLECULES

Gerber,André [CH]; Nairz, Knud [CH]

Score: 16.644737 | Text size: 231521 | Find: similardocuments

compoundlibrary or chemical library such as, for example, Enzo Life Science'slibrary, ChemDiv library, the SPECS library or the Chembridgelibrary. ... from a compound library or chemical library such as, for example,Enzo Life Science's library, ChemDiv library, the SPECSlibrary or the Chembridge library. ... from a compound library or chemicallibrary such as, for example, Enzo Life Science's library, ChemDiv library,the SPECS library or the Chembridge library.

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STRUCTURE OF INSULIN IN COMPLEX WITH N- AND C-TERMINAL REGIONS OF THEINSULIN RECEPTOR ALPHA-CHAIN

LAWRENCE,Michael Colin [AU]; MENTING, JohnGerbrandt Tasman [AU]; SMITH, BrianJohn [AU]

Publicationdate: 2018-11-21 | Patent publication No.: EP-2901154-B1|Assignees: The Walter and Eliza Hall Institute of Medical Research [AU] | IPC: G01N33/483;C07K1/32; C07K14/62; C07K14/72; G01N23/20; G01N23/207; G01N33/74; G06F19/12 | Oldest priority date: 2012-09-25 | Publication date: 2018-11-21

Score: 10.633806 | Text size: 479760 | Find: similardocuments

from, forexample, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest,Hungary) and ChemDiv(San Diego, CA), Specs (Delft, TheNetherlands).

External link

PEPTIDES AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS

SHEN, Yingjie[US];GU, Yuanzheng[US];XU, Kui [US]

Score: 12.892465 | Text size: 151410 | Find: similardocuments

ChemBridgeCorporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA,www.chembridge.com);ChemDiv (6605 Nancy Ridge Drive, San Diego, CA92121, USA); Life Chemicals (1103 Orange Center Road,

CFTR REGULATORS AND METHODS OF USE THEREOF

Alan S. Verkman[US];Marc H. Levin[US];Onur Cil [US]; Sujin Lee [US]

Publicationdate: 2018-11-15 | Patent publication No.: US-20180327369-A1|Assignees: The Regents of the University of California [US] |IPC: C07D251/52; A61K45/06; A61K31/53; C07D251/46; C07D403/04; A61K31/55;A61K31/5377; C07D413/12; A61K31/496; A61P27/04; A61P1/10 | Oldest priority date: 2015-12-24 | Publication date: 2018-11-15

Score: 14.397283 | Text size: 591380 | Find: similar documents

was doneusing a diverse collection of 120,000 drug-like synthetic compounds obtainedfrom ChemDiv Inc.(San Diego, Calif., USA) and Asinex(Winston-Salem, N.C., USA). For structure-activity analysis, 600 commerciallyavailable analogs (ChemDiv Inc.) of active compounds identified in theprimary screen were tested. ... was done using a diverse collection of 120,000drug-like synthetic compounds obtained from ChemDiv Inc. (SanDiego, Calif., USA) and Asinex (Winston-Salem, N.C., USA). For structure-activityanalysis, 600 commercially available analogs (ChemDiv Inc.) of activecompounds identified in the primary screen were tested.

Pharmacological chaperones for treating obesity

FAN, Jian-qiang[US];VANLENZANO, Ken[US];LEE, Gary [US]; BOUVIER, Michel[CA];RENÉ,Patricia [CA]

Publicationdate: 2018-11-14 | Patent publication No.: EP-2933265-B1|Assignees: Amicus Therapeutics, Inc. [US]; Université de Montréal [CA] | IPC: C07K14/72;C12N5/071; A61K31/497; A61K31/505; A61K31/4164 | Oldest priority date: 2006-06-02 | Publication date: 2018-11-14

Score: 17.126425 | Text size: 145127 | Find: similardocuments

ResearchBiochemicals; Cetek Corporation; Charybdis Technologies, Inc.; ChemBridgeCorporation; ChemDiv, Inc.; ChemGenics Pharmaceuticals Inc.;ChemOvation Ltd.; ChemStar, Ltd.; Chrysalon; ComGenex, Inc. ... compounds);Maybridge 2 (704 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352compounds);ChemDiv Combilab and International (28,864 compounds);Mixed Commercial Plate 1 (352 compounds); Mixed ... ActiMol; AralBiosynthetics; ASDI Biosciences; Biotechnology Corporation of America;Chembridge;ChemDiv; Florida Center - Heterocyclic Compounds; Microsource/MSDI; NorthStar; Peakdale; Texas Retaining

External link

Compounds and methods for treating mammalian gastrointestinal microbialinfections

Lizbeth K.Hedstrom [US]; Gregory D. Cuny[US];Deviprasad R.Gollapalli [US]; SivapriyaKirubakaran [IN]; Sushil K. Maurya[GB];Boris Striepen[US];Suresh K. Gorla[IN];Corey R. Johnson[US];MandapatiKavitha [IN]; Jihan Khan [US]

Publicationdate: 2018-11-13 | Patent publication No.: US-10125116-B2|Assignees: Brandeis University [US]; University of Georgia Research Foundation, Inc.[US]; The Brigham and Women's Hospital, Inc. [US] | IPC: C07D401/12;C07C233/15; C07C235/24; C07C235/38; C07C237/20; C07C255/60; C07C275/28;C07C275/30; C07C275/42; C07C309/15; C07D209/08; C07D209/12; C07D209/30;C07D215/38; C07D235/26; C07D237/32; C07D263/56; C07D263/57; C07D295/192;C07D401/04; C07D401/14; C07D409/04; C07D413/04; C07D417/04; C07D417/14;C07D471/08; C07D491/052; C07D249/06 | Oldestpriority date: 2009-03-20 | Publication date: 2018-11-13

Score: 10.633806 | Text size: 238357 | Find: similardocuments

Compounds D,E, F, G, and H were purchased from ChemDiv Inc. (San Diego,Calif.), Compounds A, B and C were synthesized as described previously.

Pro-Neurogenic Compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Publicationdate: 2018-11-08 | Patent publication No.: US-20180318255-A1|Assignees: Board of Regents of the University of Texas System [US] | IPC: A61K31/403;A61K31/4439; C07D403/12; C07D209/56; C07D487/04; C07F5/02; C07D209/88;C07D209/86; C07D209/08; C07D495/04; C07D471/04; C07D413/06; C07D405/12;C07D403/06; C07D401/12; C07D401/06 | Oldestpriority date: 2009-01-09 |Publicationdate: 2018-11-08

Score: 17.703602 | Text size: 718508 | Find: similar documents

compound canbe purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00139]] This compound can be purchased from ChemDiv, Inc.Example61 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00140]] This compound can be purchased from ChemDiv, Inc. Example62 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00141]] This compound can be purchased from ChemDiv, Inc. Example63 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00142]] This compound can be purchased from ChemDiv, Inc. Example

METHODS OF TREATING MUSCULAR DYSTROPHY

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2018-11-08 | Patent publication No.: US-20180318380-A1|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THEUNIVERSITY OF NEVADA [US] | IPC: A61K38/05; A61K45/06; A61K31/16; A61K31/661; A61K31/575; A61K31/57;A61K31/551; A61K31/541; A61K31/5383; A61K31/5377; A61K31/5375; A61K31/5365;A61K31/53; A61K31/519; A61K31/506; A61K31/4985; A61K31/498; A61K31/496;A61K31/473; A61K31/4709; A61K31/47; A61K31/444; A61K31/4418; A61K31/4402;A61K31/4365; A61K31/426; A61K31/421; A61K31/4196; A61K31/4178; A61K38/39;A61K31/19; A61K31/415; A61K31/41; A61K31/4035; A61K31/4025; A61K31/381; A61K31/37;A61K31/36; A61K31/343; A61K31/341; A61K31/277; A61K31/20; A61K31/404;A61K31/4164 | Oldestpriority date:2012-09-10 | Publication date: 2018-11-08

Score: 14.190399 | Text size: 216692 | Find: similardocuments

METHODS AND COMPOSITIONS TO TREAT CANCER

WHITSETT,Jeffrey [US]; MAEDA, Yutaka[US]

Score: 14.039395 | Text size: 66477 | Find: similar documents

3-[2-(4-fluorobenzyl)imidazo[2,1-beta][1,3]thiazol-6-yl]-2H-chromen-2-one(iMDK) purchased from ChemDiv(San Diego, CA) was dissolved in DMSO.

External link

ANTI-CANCER COMPOUNDS TARGETING RAL GTPASE

THEODORESCU, Dan[US];WEMPE, Michael,Fitzpatrick [US]; ROSS, David [US]; MEROUEH, Samy[US];SCHWARTZ,Martin, A. [US]; REIGAN, Phillip[US]

Publicationdate: 2018-10-31 | Patent publication No.: EP-2793881-B1|Assignees: The Regents of the University of Colorado [US]; University of VirginiaPatent Foundation [US]; Indiana University Research and Technology Corporation[US] |IPC: A61K31/351; A61K31/4162; A61K31/437; A61K31/505; A61K31/5513; A61K45/06;A61P35/00; A61P35/04; C07D491/052 | Oldestpriority date: 2011-12-21 | Publication date: 2018-10-31

Score: 12.484504 | Text size: 138493 | Find: similardocuments

To do so,RalA-GDP was set up for docking, and the ChemDiv library(v2006.

External link

Methods and compositions for treatment of fibrosis

David J. Tweardy[US];Moses M.Kasembeli [US]; Marvin X. Xu[CN];Sandeep K.Agarwal [US]; Mesias Pedroza[US]

Publicationdate: 2018-10-30 | Patent publication No.: US-10112933-B2|Assignees: BAYLOR COLLEGE OF MEDICINE [US] | IPC:C07D417/12;A61K31/18; C07C317/28; C07C317/30; C07C317/32; C07D213/71; C07D215/06;C07D231/18; C07D239/60; C07D261/10; C07D333/34; C07D409/12; C07D413/12;A61K31/343; A61K31/39; A61K31/4196; A61K45/06 | Oldest priority date: 2013-07-18 | Publication date: 2018-10-30

Score: 15.5924425 | Text size: 191754 | Find: similardocuments

Commercialchemical databases (Chembridge, Asinex, ChemDiv, Enamine,Keyorganics and Life Chemicals) were chosen as sources of compounds forscreening in ... The databases searched included ChemBridge, LifeChemicals,Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for atotal of 2.47 million compounds.

ALK Kinase Inhibitor and its use

Xiao-Jun Yao[MO];Elaine Lai-HanLeung [MO];Lian-Xiang Luo[MO];Liang Liu [MO]

Score: 14.557414 | Text size: 57121 | Find: similardocuments

The compoundof Formula (V) was purchased from ChemDiv.

Yeast cells expressing TAR DNA-binding protein 43 and uses therefor

Susan L.Lindquist [US]; Aaron D. Gitler[US]

Score: 14.165414 | Text size: 75794 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Selective calcium channel antagonists

Dalton J.Surmeier, Jr. [US]; Richard B.Silverman [US]; Soo Sung Kang[US];Garry Cooper[US]

Score: 13.556976 | Text size: 114377 | Find: similardocuments

to screen60,480 commercial compounds (ADSI set 6,800; ChemBridge diverse/lead like set20,000; ChemDivdiverse set 30,000; NIH clinical trial set 480,NCI/DTP set 3,200).

RNA-Focused Small Molecules for Inhibiting RNA Toxicity in MyotonicDystrophy

Matthew D.Disney [US];Suzanne Rzuczek[US]

Score: 13.793969 | Text size: 97035 | Find: similardocuments

Compounds 8and 25 were obtained from ChemDiv, Inc. Compounds 14, 23, and27 were purchased from Sigma-Aldrich.

RESPIRATORY AND SWEAT GLAND IONOCYTES

RAJAGOPAL,Jayaraj [US]; REGEV, Aviv [US]; BITON, Moshe[US];HABER, Adam [US]; MONTORO, Daniel[US];ROZENBLATT-ROSEN,Orit [US];RAJAGOPAL,Jayaraj [US]; REGEV, Aviv [US]; BITON, Moshe[US];HABER, Adam [US]; MONTORO, Daniel[US]

Publicationdate: 2018-10-18 | Patent publication No.: WO-2018191520-A1|Assignees: THE BROAD INSTITUTE, INC. [US]; THE GENERAL HOSPITAL CORPORATION [US];MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US] | IPC: C12N5/071 | Oldest priority date: 2017-04-12 |Publicationdate: 2018-10-18

Score: 7.874651 | Text size: 518033 | Find: similardocuments

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive ChemistryLtd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.

METHODS FOR PRODUCING ENTEROENDOCRINE CELLS THAT MAKE AND SECRETE INSULIN

TALCHAI, Chutima[US];ACCILI, Domenico[US]

Publicationdate: 2018-10-17 | Patent publication No.: EP-2569430-B1|Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: C12N15/113;C07H21/04; A61K31/7088; A61K31/713; A61K39/00; A61P3/08 | Oldest priority date: 2010-05-12 | Publication date: 2018-10-17

Score: 11.239684 | Text size: 195304 | Find: similardocuments

External link

Recombinant RSV reporter virus

Richard K.Plemper [US]; Dan Yan [US]

Score: 16.234026 | Text size: 141225 | Find: similardocuments

Corporation(16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA,www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, SanDiego, Calif. ... The screening library was obtained from ChemDiv.

Schizophrenia-associated genetic loci identified in genome wide associationstudies and methods of use thereof

Hakon Hakonarson[US];Patrick Sleiman[US];Xiao Chang [US]

Publicationdate: 2018-10-16 | Patent publication No.: US-10100362-B2|Assignees: The Children's Hospital of Philadelphia [US] | IPC:C12Q1/68; G01N33/68; C12Q1/6883; G01N33/50 | Oldest priority date: 2013-03-14 | Publication date: 2018-10-16

Score: 13.327991 | Text size: 147817 | Find: similardocuments

Austria),BioFocus DPI (Switzerland), Bionet (Camelford, UK), Chembridge (San Diego,Calif.), ChemDiv (San Diego, Calif.

COMPOUNDS AND METHODS FOR PROMOTING STRESS RESISTANCE

Cynthia Kenyon[US];Peichuan Zhang[US];James Cregg [US]; Kean-Hooi Ang[US];Michelle Arkin[US]

Publicationdate: 2018-10-11 | Patent publication No.: US-20180289682-A1|Assignees: The Regents of the University of California [US] |IPC: A61K31/443; A61K31/12; A61K31/4184; A61K31/4439; A61K31/341; A61K31/404;A61K31/519; A61K31/55; A61K31/437; A61K31/4406; A61K31/45; A61P35/00; A61P3/10;A61P9/00; A61P29/00 | Oldestpriority date: 2015-10-08 | Publication date: 2018-10-11

Score: 7.2924438 | Text size: 624038 | Find: similardocuments

a “diversitylibrary” that contains 104,121 small molecules ( ̃24K from ChemBridge;̃50K from ChemDiv; and ̃30K from SPECS) selected tomaximize the coverage of chemical space.

SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATINGCELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATINGDISORDERS

WALENSKY, Loren,D. [US];STEWART,Michelle, L. [US]; COHEN, Nicole[US]

Publicationdate: 2018-10-10 | Patent publication No.: EP-2528893-B1|Assignees: Dana-Farber Cancer Institute, Inc. [US] | IPC:C07C251/20; C07D215/16; C07D249/08; A61K31/41; A61P35/00; C07D403/04;C07D403/08; C07C335/16; C07C251/84 | Oldestpriority date:2010-01-29 | Publication date: 2018-10-10

Score: 12.290053 | Text size: 126505 | Find: similardocuments

CellularBiology at Harvard Medical School and employed commercial libraries (Asinex,Chembridge,ChemDiv, Enamine, Life Chemicals, and Maybridge).

External link

COMPOUNDS, COMPOSITIONS, ANDMETHODS FOR REDUCING OR ELIMINATING BITTER TASTE

BRENNAN, FrancisXavier [US];JONES, WilliamP. [US];LELAND, Jane V.[US];HAYASHI, David[US]

Publicationdate: 2018-09-12 | Patent publication No.: EP-2768492-B1|Assignees: Chromocell Corporation [US]; Kraft Foods Group Brands LLC [US] | IPC: A61K31/045;A61K47/00; A23L27/40 | Oldestpriority date: 2011-10-20 | Publication date: 2018-09-12

Score: 12.290053 | Text size: 151418 | Find: similardocuments

may beobtained from commercial vendors for synthetic and natural compounds, such asVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

External link

Genetic alterations on chromosomes 21Q, 6Q and 15Q and methods of usethereof for the diagnosis and treatment of type 1 diabetes

Hakon Hakonarson[US];Struan FrederickAirth Grant [US]; Jonathan PaulBradfield [US]; ConstantinPolychronakos [CA]; Hui-Qi Qu [US]

Publicationdate: 2018-09-04 | Patent publication No.: US-10066266-B2|Assignees: The Children's Hospital of Philadelphia [US] | IPC:C07H21/02; C07H21/04; C12Q1/6883; A61K38/28; C12N15/113 | Oldest priority date: 2008-05-16 | Publication date: 2018-09-04

Score: 13.10661 | Text size: 139040 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Flavors, flavor modifiers, tastants, taste enhancers, umami or sweettastants, and/or enhancers and use thereof

Publicationdate: 2018-08-28 | Patent publication No.: US-10060909-B2|Assignees: Senomyx, Inc. [US] | IPC: G01N33/543; G01N33/50; A61K8/55; A61K47/22; A61K8/49; A61K47/24;C07C233/65; C07C235/54; C07C275/30; C07C275/34; C07D307/84; C07D317/68;G01N33/566; G01N33/74; A23L2/56; C07D405/12; C07F9/655; A23L27/00; A23L27/20 | Oldest priority date: 2003-08-06 | Publication date: 2018-08-28

Score: 8.94598 | Text size: 387718 | Find: similardocuments

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia Pa., ChemDiv of San Diego Calif., Chembridge ofSan Diego Calif.

Positive allosteric modulators of mGluR3

Justin Potnick[US]

Publicationdate: 2018-08-28 | Patent publication No.: US-10059671-B2|Assignees: PREXTON THERAPEUTICS SA [CH] | IPC: C07D217/26; C07D213/85; C07D491/052; C07D495/04; A61K31/438; A61K31/472;A61K31/5377 | Oldestpriority date: 2013-02-04 | Publication date:2018-08-28

Score: 17.9036 | Text size: 90818 | Find: similardocuments

No.CommercialSource 4 Amb17360718 Ambinter 3 5921-0170 ChemDiv 8STOCK1S60655 Interbioscreen 7 5921-0172 ChemDiv 28640-0536 ChemDiv 6 STOCK1S39100 Interbioscreen 5 STOCK6S08899Interbioscreen TABLE 1 Compound No.

METHODS OF TREATING MUSCULAR DYSTROPHY

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2018-08-23 | Patent publication No.: US-20180235932-A1|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THEUNIVERSITY OF NEVADA, [US] | IPC: A61K31/404; A61K45/06 | Oldestpriority date: 2013-03-15 |Publicationdate: 2018-08-23

Score: 10.089907 | Text size: 347047 | Find: similardocuments

et al.,2006). 2) DIVERSet library (Chembridge Corp., San Diego, Calif.) and compoundsfrom the ChemDivlibrary. 3) LOPAC library (Sigma-RPI) consists of1280 pharmaceutically active compounds.

BRAIN OSTEOCALCIN RECEPTOR AND COGNITIVE DISORDERS

KARSENTY, Gerard[US];OBRI, Arnaud[US];KHRIMIAN, Lori[US]

Publicationdate: 2018-08-23 | Patent publication No.: WO-2018152292-A1|Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US] | IPC: A61K38/22;A61K9/00 | Oldestpriority date: 2017-02-15 | Publication date: 2018-08-23

Score: 10.633806 | Text size: 259184 | Find: similardocuments

MaybridgeHitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds);ChemDiv Combilaband International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds);Mixed

HIGH PRECISION SPECTRAL FRET ASSAYS

Tory M. Schaaf[US];David D. Thomas[US];Benjamin Grant[US];Kurt C. Peterson[US];Gregory D.Gillispie [US]

Publicationdate: 2018-08-23 | Patent publication No.: US-20180238901-A1|Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA [US] | IPC: G01N33/68;G01N33/52; G01N33/542; G01N33/58 | Oldestpriority date: 2017-01-25 | Publication date: 2018-08-23

Score: 11.918776 | Text size: 202850 | Find: similardocuments

and includeAMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridgeLibrary, ChemDivLibrary, Enamine Library, The Greenpharma NaturalCompound Library, Life Chemicals Library,

Osteocalcin as a treatment for cognitive disorders

Gerard Karsenty[US];Franck Oury [US]

Publicationdate: 2018-08-21 | Patent publication No.: US-10052364-B2|Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: A61K38/22;G01N33/68 | Oldestpriority date: 2013-03-15 | Publication date: 2018-08-21

Score: 10.089907 | Text size: 334642 | Find: similardocuments

MaybridgeHitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds);ChemDiv Combilaband International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds);Mixed

Electrophysiological assays using oocytes that express human ENaC and theuse of phenamil to improve the effect of ENaC enhancers in assays usingmembrane potential reporting dyes

Guy Servant [US]; Hong Chang [US]; Cyril Redcrow[US];Sumita Ray [US]; Imran Clark [US]; Bryan Moyer [US]

Score: 12.484504 | Text size: 153382 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

High-affinity small molecule formylpeptide receptor ligands fromscreening of combinatorial mixture-based libraries

Bruce S. Edwards[US];Larry A. Sklar[US];ClemenciaPinilla [US]; Richard A.Houghten [US]; Jon R. Appel[US];Marc A.Giulianotti [US]; JoseMedina-Franco [US]

Publicationdate: 2018-08-14 | Patent publication No.: US-10048272-B2|Assignees: STC.UNM [US]; Torrey Pines Institute for Molecular Studies [US] | IPC: A61K31/497;A61K31/517; A61K31/17; G01N33/68; C07D403/14; A61K31/496; A61K45/06;C07C275/28; C40B30/02; G01N33/74; A61K38/00; C07D241/08; C07K1/04 | Oldest priority date: 2013-02-07 | Publication date: 2018-08-14

Score: 12.290053 | Text size: 203716 | Find: similardocuments

on the basisof a preliminary computational screen of 480,000 compounds from thecommercial ChemDivcollection using an FPR homology model andpharmacophore (Edwards, et al., 2005).

INHIBITORS OF HIV-1 INTEGRASE MULTIMERIZATION

ANDRAKE, Mark D.[US];SKALKA, AnnaMarie [US];MERKEL, GeorgeW. [US]

Publicationdate: 2018-08-02 | Patent publication No.: WO-2018140762-A1|Assignees: INSTITUTE FOR CANCER RESEARCH d.b.a THE RESEARCH INSTITUTE OF FOX CHASECANCER CENTER [US] | IPC: A61K39/395 | Oldestpriority date: 2017-01-26 | Publication date: 2018-08-02

Score: 17.397278 | Text size: 55551 | Find: similardocuments

IB), andused it to screen the 50,000 compound chemical diversity library of ChemDiv,ltd.at lOu M concentration. ... day were performed to screen the entire ChemicalDiversity set of 50,000 compounds obtained from ChemDiv, Ltd.

PRO-NEUROGENIC COMPOUNDS

MCKNIGHT,Steven, L. [US]; PIEPER, Andrew,A. [US];READY, Joseph,M. [US];DE BRABANDER,Jef [US]

Publicationdate: 2018-08-01 | Patent publication No.: EP-2385829-B1|Assignees: Board of Regents of the University of Texas System [US] | IPC: A61P25/16;A61P25/28; A61P25/18; A61K31/403; A61K31/415; A61K31/437; A61K31/44; A61K31/506|Oldestpriority date: 2009-01-09 | Publication date: 2018-08-01

Score: 19.449032 | Text size: 311213 | Find: similardocuments

(reference)[[image:ib0108]] Purchased from ChemDiv, Inc. Example 59.1-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol (reference)[[image:ib0109]] Purchased from ChemDiv, Inc. Example 60.1-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol (reference)[[image:ib0110]] Purchased fromChemDiv, Inc. Example 61.1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol(reference) [[image:ib0111]] Purchased from ChemDiv, Inc. Example62. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol(reference) [[image:ib0112]] Purchased from ChemDiv, Inc. Example63. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol (reference)[[image:ib0113]] Purchased fromChemDiv, Inc. Example 64.

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Methods of treating muscular dystrophy

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2018-07-24 | Patent publication No.: US-10028992-B2|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THEUNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/415; A61K31/405; A61K38/05; A61K31/16; A61K31/343; A61K31/4418;A61K31/444; A61K31/4709; A61K31/53; A61K31/5375; A61K31/5377; A61K31/5383;A61K31/551; A61K31/57; A61K31/661; A61K45/06; A61K31/20; A61K31/4178;A61K31/5365; A61K31/575; A61K38/39; A61K31/19; A61K31/277; A61K31/341;A61K31/36; A61K31/37; A61K31/381; A61K31/4025; A61K31/4035; A61K31/41;A61K31/4196; A61K31/421; A61K31/426; A61K31/4365; A61K31/4402; A61K31/47; A61K31/473;A61K31/496; A61K31/498; A61K31/4985; A61K31/506; A61K31/519; A61K31/541;A61K31/4164; A61K31/404 | Oldestpriority date: 2012-09-10 | Publication date: 2018-07-24

Score: 13.939713 | Text size: 290051 | Find: similardocuments

Heidelberg);the DIVERSet library (Chembridge Corp., San Diego, Calif.) and compounds fromthe ChemDivlibrary. ... Increased A7 Expression MyotubesIncreasedA7 Expression Commercially (Obtained + Myoblasts from ChemDiv Library)EC100 Myoblasts Only 5α-cholestan-20 μM + NA 3β-ol-6-oneN032-0333 12.

IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE

Phillip C. Liu[US];Alla Volgina[US];Richard Wynn[US];Nina Zolotarjova[US];Liangxing Wu[US];Kaijiong Xiao[US];Song Mei [US]; Liang Lu [US];Wenyu Zhu [US]; Yingda Ye [US]; Haisheng Wang[US];Ding-Quan Qian[US];Wenqing Yao [US]

Publicationdate: 2018-06-28 | Patent publication No.: US-20180177870-A1|Assignees: Incyte Corporation [US] | IPC: A61K39/39; A61K45/06; G01N33/50; C07D471/04; C07D213/81; C07D519/00;C07D413/06; C07D263/57; C07D413/14; A61P35/00; A61P37/04 | Oldest priority date: 2016-12-22 | Publication date: 2018-06-28

Score: 7.572373 | Text size: 636740 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

METHODS AND COMPOSITIONS TO TREAT CANCER

Jeffrey Whitsett[US];Yutaka Maeda[US]

Score: 14.039395 | Text size: 62344 | Find: similardocuments

3-[2-(4-fluorobenzyl)imidazo[2,1-beta][1,3]thiazol-6-yl]-2H-chromen-2-one(iMDK) purchased from ChemDiv(San Diego, Calif.) was dissolved inDMSO.

TETRAHYDRO IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS PD-L1 INTERNALIZATIONINDUCERS

LIU, Phillip C.[US];VOLGINA, Alla[US];WYNN, Richard[US];ZOLOTARJOVA,Nina [US];WU, Liangxing[US];XIAO, Kaijiong[US];MEI, Song [US]; LU, Liang [US]; ZHU, Wenyu [US]; YE, Yingda [US]; WANG, Haisheng[US];QIAN, Ding-Quan[US];YAO, Wenqing[US]

Score: 7.572373 | Text size: 592953 | Find: similar documents

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

SMALL MOLECULE FERROPTOSIS INDUCERS

STOCKWELL, BrentR. [US]

Publication date: 2018-06-28 | Patentpublication No.: WO-2018118711-A1|Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US] | IPC: A61K31/15;A61K31/18; C07C13/567 | Oldestpriority date: 2016-12-19 | Publication date: 2018-06-28

Score: 12.685205 | Text size: 137488 | Find: similardocuments

compounds,as well as structural analogs of CIL41/70, were purchased from Asinex,ChemBridge, ChemDiv, Enamine, InterBioScreen, MayBridge, TimTec,Vitas M Labs, and Zelinsky.

ASSOCIATION OF RARE RECURRENT GENETIC VARIATIONS TO ATTENTION-DEFICIT,HYPERACTIVITY DISORDER (ADHD) AND METHODS OF USE THEREOF FOR THE DIAGNOSIS ANDTREATMENT OF THE SAME

GLESSNER, Joseph[US];ELIA, Josephine[US];HAKONARSON,Hakon [US]

Score: 12.290053 | Text size: 201627 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

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Lin28/let-7 crystal structures, purification protocols, and molecularprobes suitable for screening assays and therapeutics

Piotr Sliz [US]; Yunsun Nam [US]

Publicationdate: 2018-06-19 | Patent publication No.: US-10000756-B2|Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: A61K48/00;C07H21/04; C12N15/113; A61K45/06; A61K31/713 | Oldest priority date: 2011-11-09 | Publication date: 2018-06-19

Score: 10.354719 | Text size: 297912 | Find: similardocuments

2, Prestwick2 Collection, MSDiscovery 1, Biomol ICCB Know Bioactives, Asinex 1, ChemBridge3, ChemDiv 4 and 6, Life Chemicals 1, and Maybridge 4 and 5.These libraries can be screened using the

Small molecules for the modulation of MCL-1 and methods of modulatingcell death, cell division, cell differentiation and methods of treatingdisorders

Loren D.Walensky [US]; Michelle L.Stewart [US]; Nicole Cohen[US]

Publicationdate: 2018-06-19 | Patent publication No.: US-10000511-B2|Assignees: Dana-Farber Cancer Institute, Inc. [US] | IPC:C07D513/04; C07D249/12; C07D401/12; C07D413/14; C07D409/12; C07C311/20;C07D409/14; C07D405/14; C07D417/14; C07D307/54; C07D405/12; C07D409/06;C07D413/06; C07D279/06; C07D327/04; C07D239/60; C07D403/06; C07D277/34;C07D417/04; C07C337/08; C07C251/20; C07C251/84; C07C335/16; C07D403/04;C07D403/08 | Oldestpriority date: 2010-01-29 | Publication date: 2018-06-19

Score: 11.918776 | Text size: 203235 | Find: similardocuments

CellularBiology at Harvard Medical School and employed commercial libraries (Asinex,Chembridge,ChemDiv, Enamine, Life Chemicals, and Maybridge).

SYNAPTIC VESICLE CYCLING ASSAYS ANDSYSTEMS

Q-StateBiosciences, Inc. [US]; Q-StateBiosciences, Inc. [US]; David J. Gerber[US];Jeffrey R.Cottrell [US]; Timothy A. Ryan[US];Jonathan M.Levenson [US]

Score: 14.450268 | Text size: 266343 | Find: similardocuments

commercialvendors such as ChemBridge Libraries (chembridge.com), BIOMOL International,ASINEX,ChemDiv, ChemDB, ICCB-Longwood or alternatively synthesized denovo. ... commercial vendors such as ChemBridge Libraries (chembridge.com),BIOMOL International, ASINEX, ChemDiv, ChemDB, ICCB-Longwood.

Inhibitors of RAD52 Recombination Protein and Methods Using Same

Alexander V.MAZIN [US]

Publicationdate: 2018-05-17 | Patent publication No.: US-20180134727-A1|Assignees: DREXEL UNIVERSITY [US] | IPC: C07D495/04; C07D491/056; A61K31/4741; A61K45/06; A61P35/00; C07D471/04;A61K31/5377; C07D405/12; A61K31/4525; C07D307/82; A61K31/496; C07D215/38;C07D239/95; A61K31/517; A61K31/55 | Oldestpriority date: 2015-06-04 | Publication date: 2018-05-17

Score: 12.290053 | Text size: 146944 | Find: similardocuments

Thecompounds for confirmation analysis were purchased from Asinex Ltd., ChemBridgeCo., ChemDiv Inc, Enamine, FCH Group, Frontier Scientific ServicesInc., InterBioScreen Ltd., Life Chemicals Inc.

MODULATION OF PROTEIN ACCUMULATION AND USES THEREFOR

RAYNER,Stephanie [AU]; LEE, Albert [AU]; CHUNG, Roger[AU];BLAIR, Ian [AU]; MOLLOY, Mark[AU];GWEE, Serene[AU];YANG, Shu [AU]

Score: 11.239684 | Text size: 208132 | Find: similardocuments

Commerciallyavailable compound libraries can be obtained from, e.g., TocrisBioscience, ChemDiv, ArQule, Pharmacopia, graffinity, Panvera,Vitas-M Lab, Biomol International and Oxford.

Pro-Neurogenic Compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Publicationdate: 2018-05-10 | Patent publication No.: US-20180127367-A1|Assignees: Board of Regents of the Univeristy of Texas System [US] | IPC: C07D209/88;C07D209/82; C07D405/12; A61K31/422; A61K31/4188; A61K31/4192; A61K31/4155;C07D403/12; C07D403/06; C07D401/12; C07D401/06; C07D209/86; C07D209/08;A61K31/506; A61K31/4439; A61K31/437; A61K31/4045; A61K31/404; C07F5/02;C07D495/04; C07D471/04; C07D413/06; A61K31/403 | Oldest priority date: 2009-01-09 | Publication date: 2018-05-10

Score: 18.456491 | Text size: 507599 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 60.1-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00132]] This compound can be purchased from ChemDiv, Inc.Example61. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00133]] This compound can be purchased from ChemDiv, Inc. Example62. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00134]] This compound can be purchased from ChemDiv, Inc. Example63. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00135]] This compound can be purchased from ChemDiv, Inc. Example64.

METHODS FOR TREATMENT OF RETINAL DISEASE BY PHOTORECEPTOR GENE EXPRESSIONMODULATION

Thomas A. Reh[US];Paul Nakamura[US];Sheng Ding [US]

Publicationdate: 2018-05-10 | Patent publication No.: US-20180125847-A1|Assignees: University of Washington [US]; The J. David Gladstone Institutes, aTestamentary Trust Established Under the Will of J. David Glads [US] | IPC: A61K31/519; A61K31/426;A61K9/00; A61P27/02 | Oldestpriority date: 2015-03-27 | Publication date: 2018-05-10

Score: 18.319254 | Text size: 57098 | Find: similardocuments

Pro-neurogenic compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Publicationdate: 2018-05-08 | Patent publication No.: US-09962368-B2|Assignees: Board of Regents of the University of Texas System [US] | IPC: C07D209/88;A61K31/403; A61K31/4439; C07D403/12; C07D401/06; C07D401/12; C07D403/06;C07D405/12; C07D413/06; C07D471/04; C07D495/04; C07D209/08; C07D209/86;C07F5/02; C07D487/04; C07D209/56 | Oldestpriority date: 2009-01-09 | Publication date: 2018-05-08

Score: 17.703602 | Text size: 742093 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 60.1-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol [[image:EMI-C00139]]This compound can be purchased from ChemDiv, Inc.Example 61.1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00140]] This compound can be purchased from ChemDiv, Inc. Example62. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00141]] This compound can be purchased from ChemDiv, Inc. Example63. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00142]] This compound can be purchased from ChemDiv, Inc. Example64.

Use of small molecule inhibitors targeting EYA tyrosine phosphatase

Rashmi Hegde[US]

Score: 11.569273 | Text size: 172026 | Find: similardocuments

L129305) andcompound 1b from ChemDiv (cat. no. 3039-0682).

SMALL MOLECULE INHIBITORS OF TLR2 SIGNALING

Stefanie N.Vogel [US];AlexanderMacKerell [US]

Publicationdate: 2018-04-26 | Patent publication No.: US-20180110746-A1|Assignees: University of Maryland, Baltimore [US] | IPC:A61K31/196; A61K31/11; A61K31/513; A61K31/437; A61K31/381; A61K31/5377;A61K31/4439; A61K31/519; A61K31/517; A61K31/18; A61K45/06; A61P29/00 | Oldest priority date: 2015-04-06 | Publication date: 2018-04-26

Score: 20.166632 | Text size: 89928 | Find: similardocuments

thefollowing chemical structure: [[image:EMI-C00001]] Compound C10 is availablecommercially fromChemDiv (San Diego, Calif.) as compound chemdiv4011686.Compound C14 refers to a compound having the following chemical structure:[[image:EMI-C00002]] Compound C14 is available commercially from ChemDiv(SanDiego, Calif.) as compound chemdiv4033090. Compound C24 refers to a compoundhaving the following chemical structure: [[image:EMI-C00003]] Compound C24 isavailable commercially from ChemDiv (San Diego, Calif.) ascompound chemdiv4124964. Compound C25 refers to a compound having the followingchemical structure: [[image:EMI-C00004]] Compound C25 is available commerciallyfrom ChemDiv (San Diego, Calif.) as compound chemdiv4166820.

MUCOADHESIVE DEVICES FOR DELIVERY OF ACTIVE AGENTS

Baruch Z. HARRIS[US];Vijay M. K.MURTHY [US];David AdamSTEINBERG [US]; Rodney PEARLMAN[US];Howard BrianROSEN [US];Robert SamuelLANGER [US];HilaESPTEIN-BARASH [US]; Jonathan RobertBEHR [US];Samir SureshMITRAGOTRI [US]

Publicationdate: 2018-04-12 | Patent publication No.: US-20180098934-A1|Assignees: ENTREGA, INC. [US]; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K9/00;A61K9/20; A61K38/23; A61K38/28 | Oldestpriority date: 2012-06-14 | Publication date:2018-04-12

Score: 12.290053 | Text size: 141526 | Find: similardocuments

fromcommercial and academic sources, for example. from Sigma-Aldrich(www.sigmaaldrich.com), ChemDiv(www.chemdiv.com), Evotec (www.evotec.comor ICCB (iccb.med.harvard.

Prolylhydroxylase inhibitors and methods of use

Ratan, Rajiv R[US];Gazaryan, Irina[US];Smirnova,Natalya [US]

Publicationdate: 2018-04-11 | Patent publication No.: EP-2891649-B1|Assignees: Cornell University [US] | IPC: C07D209/18; C07D401/12; A61K31/404; A61K31/4709; A61P9/00; A61P25/00 | Oldest priority date: 2010-02-23 | Publication date: 2018-04-11

Score: 16.234026 | Text size: 140267 | Find: similardocuments

160validated hits The screen of 85,000 compounds library (including those fromSpectrum, ChemDiv, AMRI, ChemBridge. ... Extended SAR analysis Oxyquinolineswere purchased from ChemDiv (San Diego, CA) and tested in96-format plates with varied concentrations of an inhibitor (0.

External link

Pharmacological chaperones for treating obesity

Jian-Qiang Fan[US];KennethValenzano [US]; Gary Lee [US]; Michel Bouvier[CA];PatriciaRené [CA]

Publicationdate: 2018-04-10 | Patent publication No.: US-09937165-B2|Assignees: Amicus Therapeutics, Inc. [US]; Universite de Montreal [CA] | IPC: A61K31/505;A61K31/495; A61K31/497; A61K9/00 | Oldestpriority date: 2005-06-03 | Publication date: 2018-04-10

Score: 17.126425 | Text size: 142063 | Find: similardocuments

ResearchBiochemicals; Cetek Corporation; Charybdis Technologies, Inc.; ChemBridgeCorporation; ChemDiv, Inc.; ChemGenics Pharmaceuticals Inc.;ChemOvation Ltd.; ChemStar, Ltd.; Chrysalon; ComGenex, Inc. ... compounds);Maybridge 2 (704 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352compounds);ChemDiv Combilab and International (28,864 compounds);Mixed Commercial Plate 1 (352 compounds); Mixed ... ActiMol; AralBiosynthetics; ASDI Biosciences; Biotechnology Corporation of America;Chembridge;ChemDiv; Florida Center—Heterocyclic Compounds;Microsource/MSDI; NorthStar; Peakdale; Texas Retaining

ISOXAZOLE-AMIDES FOR TREATING CARDIAC DISEASES

KINNUNEN, Sini[FI];TÖLLI,Marja [FI];VÄLIMÄKI,Mika [FI];JUMPPANEN,Mikael [FI];BOIJE AFGENNÄS, Gustav [FI]; YLI-KAUHALUOMA,Jari [FI];RUSKOAHO, Heikki[FI]

Publicationdate: 2018-03-29 | Patent publication No.: WO-2018055235-A1|Assignees: UNIVERSITY OF HELSINKI [FI]; UNIVERSITY OF OULU [FI] | IPC: C07D261/18;C07D413/12; C07D417/12; C07D413/04; C07D413/14; A61K31/42; A61P9/00 | Oldest priority date: 2016-09-21 |Publicationdate: 2018-03-29

Score: 12.484504 | Text size: 124613 | Find: similardocuments

C5.8 waspurchased from Maybridge (Catalog code: SPB03213) C6.1 Compound C6.1 waspurchased fromChemDiv (Catalog code: G794- 1887) C6.2 Compound C6.

COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENTOF AML USING USP10 BIOMARKERS AND MODULATORS

BUHRLAGE, Sara[US];WEISBERG, Ellen[US];BUHRLAGE, Sara[US];WEISBERG, Ellen[US]

Score: 8.202065 | Text size: 450073 | Find: similardocuments

HBX19818analogs were purchased from ChemDiv and dissolved in DMSO toobtain a 10 mM stock solution.

Multivalent RAS binding compounds

Brent R.Stockwell [US]; Matthew Welsch[US]

Publicationdate: 2018-03-27 | Patent publication No.: US-09926293-B2|Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: C07D209/14;A61K31/496; C07D401/12; C07D403/12; C07D401/14; C07D295/108 | Oldest priority date: 2014-05-30 |Publicationdate: 2018-03-27

Score: 10.928354 | Text size: 216763 | Find: similardocuments

availablecompounds were compiled from the inventories of Asinex, Enamine,Chembridge, ChemDiv, IBS, Life, Maybridge and TimTec.

Treatment or prophylaxis of proliferative conditions

Steven AlbertEverett [US]; Saraj Ulhaq [GB]

Publicationdate: 2018-03-20 | Patent publication No.: US-09919060-B2|Assignees: University Court of the University of Dundee [GB] |IPC: A61K47/48; A61K31/37; A61K31/52; A61K31/343; A61K31/381; A61K31/428;A61K31/513; A61K31/665; A61K47/54; C07D491/22; C07D487/04; C07D417/12;C07D409/12; C07D407/12; C07D405/14; C07D405/12; C07D405/04; C07D311/18;C07D311/16; C07D307/80; A61K31/664; A61K31/4184; A61K31/352 | Oldest priority date: 2009-05-01 | Publication date: 2018-03-20

Score: 15.970954 | Text size: 249958 | Find: similardocuments

for CYP1B1The target enzyme CYP1B1 was screened against two commercial librariesincluding the ChemDivDiversity 50,000 test compound collection andthe ChemDiv Kinase Targeted 10,000 test compound collectionwith a view to identifying activity differentiating ... cross validation on atraining set selected from 45,000 and 9,000 test compounds from the ChemDiv Diverseand Kinase libraries.

RNF41 AS A BIOMARKER PREDICTING RESPONSE TO LENALIDOMIDE IN NON-DEL(5Q)MDS

Alan List [US]

Publicationdate: 2018-03-15 | Patent publication No.: US-20180073078-A1|Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: C12Q1/68;A61K31/454; A61K45/06; G01N33/574; G01N33/573 | Oldest priority date: 2012-12-05 | Publication date: 2018-03-15

Score: 14.831028 | Text size: 44463 | Find: similardocuments

Corporation(16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA,www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, San Diego,Calif.

NOVEL OXADIAZOLE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME

KatsuhikoYanagisawa [JP]; Akiyoshi Kawai[JP]

Publicationdate: 2018-03-15 | Patent publication No.: US-20180072708-A1|Assignees: National Center for Geriatrics and Gerontology [JP] | IPC: C07D413/04;C07D413/14; C07D413/12; C07D413/06; C07D285/08; C07D285/12; C07D271/06;C07D271/10 | Oldestpriority date:2015-03-25 | Publication date: 2018-03-15

Score: 10.928354 | Text size: 283076 | Find: similardocuments

UORSY Ltd., Vitas-MLaboratory Ltd., Interbioscreen Ltd., Interchim Inc., Ryan ScientificInc., ChemDiv Inc., through Namiki Shoji Co., Ltd. or KishidaChemical Co., Ltd., when purchased in Japan.

COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATICSYSTEM DISORDERS

HAKONARSON, Hakon[US];LI, Dong [US]; TIAN, Lifeng[US];NGUYEN, Kenny[US];SLEIMAN, Patrick[US]

Score: 12.290053 | Text size: 152849 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

LIPID CONTAINING FORMULATIONS

MuthiahManoharan [US]; KallanthottathilG. Rajeev [US]; Akin Akinc [US]; Jayaprakash K.Nair [US];MuthusamyJayaraman [US]; Martin Maier[US]

Publicationdate: 2018-03-08 | Patent publication No.: US-20180065918-A1|Assignees: Arbutus Biopharma Corporation [CA] | IPC:C07C219/06; C07C323/25; C07C271/10; C07C233/36; A61K9/127; C07C209/78;A61K31/325; A61K47/34 | Oldestpriority date: 2006-10-03 |Publicationdate: 2018-03-08

Score: 10.354719 | Text size: 272764 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, SanDiego, Calif.

Selective inhibitors of constitutive androstane receptor

Taosheng Chen[US];Milu Cherian[US];Wenwei Lin [US]

Publicationdate: 2018-03-06 | Patent publication No.: US-09908890-B2|Assignees: St. Jude Children's Research Hospital [US] | IPC:C07D487/08; C07D403/06; C07D401/06; C07D409/06; C07D403/14; C07D401/14;C07D413/14; C07D405/12; C07D223/28; C07D223/22 | Oldest priority date: 2014-10-20 | Publication date: 2018-03-06

Score: 11.501497 | Text size: 513556 | Find: similardocuments

Allylisothiocyanate and chemicals 81, 82, 84, 87, and 89 were purchased from ChemDiv (SanDiego, Calif. ... the compound has the structure given by the formula:[[image:EMI-C00159]] CINPA1 was obtained fromChemDiv (San Diego,Calif.

2,3-dihydro-1H-indole compounds

Jolie AnneBastian [US]; Jiehao Chen [US]; Jeffrey DanielCohen [US];James RobertHenry [US];William ThomasMcMillen [US]; Bradley EarlReaman [US];Almudena Rubio[US];Daniel Jon Sall[US];Gaiying Zhao[US]

Publicationdate: 2018-01-23 | Patent publication No.: US-09872853-B2|Assignees: Eli Lilly and Company [US] | IPC: A61K31/403; C07D209/12; C07D209/02; C07C233/57; C07C233/01; C07D309/00 | Oldest priority date: 2016-06-10 | Publication date: 2018-01-23

Score: 12.484504 | Text size: 128944 | Find: similardocuments

of unlabeled1-(2,4-difluorophenyl)-3-{[1-(phenylcarbonyl)-2,3-dihydro-1H-indol-5-yl]methyl}urea(ChemDiv, Cat# G714-0242)) 100 μM to 50 nM

Compounds, compositions, and methods for reducing or eliminating bittertaste

Kambiz Shekdar[US];Daniel Lavery[US];Joseph Gunnet[US];Jessica Langer[US];Jane V. Leland[US];David Hayashi[US];Peter H. Brown[US];Louise Slade[US];William P. Jones[US]

Publicationdate: 2018-01-23 | Patent publication No.: US-09872514-B2|Assignees: Chromocell Corporation [US] | IPC: A61K47/00; A23L27/00; A61K47/06; A61K47/08; A61K47/10; A61K47/12;A61K47/14; A61K47/22; A61K47/44; C07C63/06; C07C69/78; C07D311/20; C07D311/22;C07D311/72; A23L27/20; A23L27/16; A61K47/02 | Oldest priority date: 2010-04-15 | Publication date: 2018-01-23

Score: 8.557886 | Text size: 397804 | Find: similardocuments

wereobtained from commercial vendors for synthetic and natural compounds, includingVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

YEAST CELLS EXPRESSING AMYLOID BETA AND USES THEREFOR

Kent E.S.Matlack [US]; Susan L.Lindquist [US]; SebastianTreusch [US]

Score: 14.039395 | Text size: 76609 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT ORPREVENTION OF MALARIA

Sanjay A. Desai[US]

Publicationdate: 2018-01-18 | Patent publication No.: US-20180015086-A1|Assignees: The United States of America, as represented by the Secretary, Departmentof Health and Human Serv [US] | IPC: A61K31/501; A61K31/422; C07K16/20; C07K14/445; C07D513/04; C07D498/04;C07D491/048; C07D417/06; C07D413/14; C07D409/04; C07D281/16; C07D277/54;C07D263/57; C07D241/44; C07D239/84; A61K45/06; A61K31/42; A61K31/554;A61K31/519; A61K31/517; A61K31/50; A61K31/498; A61K31/496; A61K31/495;A61K31/4741; A61K31/4439; A61K31/437; A61K31/4355; A61K31/433; A61K31/427;A61K31/423; A61K39/015 | Oldestpriority date: 2011-04-12 | Publication date: 2018-01-18

Score: 15.748037 | Text size: 139266 | Find: similardocuments

methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, Calif. or Peakdale MolecularLimited, High Peak, England. ... room temperature using a commercial library of50,000 compounds with >90% purity confirmed by NMR (ChemDiv), Screenswere performed in 384-well format with individual wells containing a singlecompound at

Process for treating an individual with an esthetic defect of skin bymodulating SASPase FLG2 complex

DominiqueBernard [FR]; AgnesThomas-Collignon [FR]; Roger Rozot [FR]; Benoit Muller[FR]

Score: 18.433235 | Text size: 108823 | Find: similardocuments

modulatorycompounds that are suitable for use in the invention may be obtained from thedatabank ChemDivDiscovery Chemistry Collection Public Database(Order Number: 4477-2039), ChemDiv, Inc. San Diego, USA). ...The screening of a molecule databank HBGXS10 (ChemDiv DiscoveryChemistry Collection Public Database (Order Number: 4477-2039), ChemDiv,Inc. San Diego, USA) made it possible to identify the compound,referred to as “M7”, of formula (II)

ISOLATED HUMAN LUNG PROGENITOR CELLS AND USES THEREOF

JayarajRajagopal [US]; Hongmei Mou [US]

Publicationdate: 2017-12-28 | Patent publication No.: US-20170369839-A1|Assignees: THE GENERAL HOSPITAL CORPORATION [US] |IPC: C12N5/074; A61L27/38; C12N5/071; G01N33/68; A61L27/58; A61K35/42;A61L27/56; A61K9/00 | Oldestpriority date: 2012-01-13 |Publicationdate: 2017-12-28

Score: 9.838301 | Text size: 256485 | Find: similardocuments

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM Exclusive ChemistryLtd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.

TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

Steven AlbertEverett [US]; Saraj Ulhaq [GB]

Publicationdate: 2017-12-28 | Patent publication No.: US-20170368188-A1|Assignees: University Court of the University of Dundee [GB] | IPC: A61K47/54;A61K31/343; C07D417/12; C07D409/12; C07D407/12; C07D405/14; C07D405/12;C07D405/04; C07D311/18; C07D311/16; C07D307/80; A61K31/665; A61K31/664;A61K31/52; A61K31/513; A61K31/428; A61K31/4184; A61K31/381; A61K31/37;A61K31/352; C07D487/04; C07D491/22 | Oldestpriority date: 2009-05-01 | Publication date: 2017-12-28

Score: 15.970954 | Text size: 232983 | Find: similardocuments

2,3-DIHYDRO-1H-INDOLE COMPOUNDS

Jolie AnneBastian [US]; Jiehao Chen [US]; Jeffrey DanielCohen [US];James RobertHenry [US];William ThomasMcMillen [US]; Bradley EarlReaman [US];Almudena Rubio[US];Daniel Jon Sall[US];Gaiying Zhao[US]

Publicationdate: 2017-12-14 | Patent publication No.: US-20170354641-A1|Assignees: Eli Lilly and Company [US] | IPC: A61K31/403; C07C233/57; C07D209/02; C07C233/01; C07D309/00 | Oldest priority date: 2016-06-10 | Publication date: 2017-12-14

Score: 12.484504 | Text size: 127735 | Find: similardocuments

of unlabeled1-(2,4-difluorophenyl)-3-{[1-(phenylcarbonyl)-2,3-dihydro-1H-indol-5-yl]methyl}urea(ChemDiv, Cat# G714-0242)) 100 μM to 50 nM

1-TETRAHYDROPYRANYLCARBONYL-2,3-DIHYDRO-1H-INDOLE COMPOUNDS FOR TREATINGCANCER

BASTIAN, JolieAnne [US];CHEN, Jiehao[US];COHEN, JeffreyDaniel [US];HENRY, JamesRobert [US];MCMILLEN,William Thomas [US]; REAMAN, BradleyEarl [US];RUBIO, Almudena[US];SALL, Daniel Jon[US];ZHAO, Gaiying[US]

Score: 12.484504 | Text size: 133055 | Find: similardocuments

unlabeledl-(2,4-difluorophenyl)-3-{[l-(phenylcarbonyl)-2,3-dihydro-lH-indol-5-yl]methyl}urea (ChemDiv, Cat# G714-0242) )100 μΜ to 50 nMl-(2,4-

COMPOUNDS ACTIVE TOWARDS BROMODOMAINS

Jimmi GernerSEITZBERG [SE]; Tine TitilolaAkinlemnu KRONBORG [DK]; Visnja POLJAK[DK];Gitte FRIBERG[DK];Lene TEUBER [DK]

Publicationdate: 2017-12-07 | Patent publication No.: US-20170349607-A1|Assignees: NUEVOLUTION A/S [DK] | IPC: C07D498/08; C07D491/107; C07D487/04; C07D471/04; C07D413/02; C07D215/227;C07D405/14; C07D405/12; C07D401/14; C07D401/12; C07D498/04; C07D413/14 | Oldest priority date: 2014-08-01 | Publication date: 2017-12-07

Score: 14.397283 | Text size: 631507 | Find: similardocuments

piperidyl)-2-morpholino-pyrimidine-5-carboxylic acid [[image:EMI-C00075]] ChemDiv 5-(benzenesulfonamido)-2-(4-methylpiperazin-1-yl)benzoic acid [[image:EMI-C00076]] ChemDiv 5-(ethylsulfonylamino)-2-(4-methylpiperazin-1-yl)benzoic acid [[image:EMI-C00077]] ChemDiv 2-(methanesulfonamido)-5-morpholino-benzoic acid [[image:EMI-C00078]] ChemDiv 6-amino-1-methyl-3,4-dihydroquinolin-2-one [[image:EMI-C00079]]

USE OF SMALL MOLECULE INHIBITORS TARGETING EYA TYROSINE PHOSPHATASE

Rashmi Hegde[US]

Score: 10.928354 | Text size: 185537 | Find: similardocuments

L129305) andcompound 1b from ChemDiv (cat. no. 3039-0682).

INHIBITION OF PROLINE CATABOLISM FOR THE TREATMENT OF CANCER AND OTHERTHERAPEUTIC APPLICATIONS

GARY K. SCOTT[US];CHRISTOPHER C.BENZ [US]

Publicationdate: 2017-12-07 | Patent publication No.: US-20170348266-A1|Assignees: Buck Institute for Research on Aging [US] | IPC:A61K31/198; A61K31/365; A61K31/496; A61K31/5377; G01N33/574; A61K31/341;A61K31/713; C12N15/113; A61K31/501 | Oldestpriority date: 2014-11-13 | Publication date: 2017-12-07

Score: 19.848673 | Text size: 222808 | Find: similardocuments

395.37 1.720 3 Aldrich 34395522 28 [[image:EMI-C00046]] 456.493 3.802 75.63 4 ChemDiv F992-0176Aldrich 111388699 29 [[image:EMI-C00047]] 427.408 2.479 105.669 4 LifeChemicals F0614-0106 Aldrich 30873123 30 [[image:EMI-C00048]] 451.468 3.5 06 ChemDiv C073-6425 Aldrich 30292264 31 [[image:EMI-C00049]]444.457 3.68 0 6 UrkOrg- Synthesis PB10136403 04 32 [[image:EMI-C00050]]557.636 3.543 106.2 8ChemDiv C073-6425 Aldrich 30292264 33[[image:EMI-C00051]] 477.56 3.886 78.66 5 ChemDiv C301-4018Aldrich 61632667 34 [[image:EMI-C00052]] 522.552 −0.639 142.93 1 Vitas-MSTK593537 Pharmeks PHAR119569 35 [[image:EMI-C00053]] 574.582 3.472 117.376 ChemDiv C090-0436 Aldrich 30295114 36 [[image:EMI-C00054]]556.589 0.69 159.

INHIBITORS OF THE NOTCH SIGNALLING PATHWAY AND SECRETION FOR USE INMEDICINE

KAETHER,Christoph [DE]; KRÄMER,Andreas [DE]

Publicationdate: 2017-12-06 | Patent publication No.: EP-2854809-B1|Assignees: Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V.(FLI) [DE] | IPC: A61K31/47; C07D215/54; A61P35/00 | Oldestpriority date: 2012-06-01 | Publication date: 2017-12-06

Score: 19.43171 | Text size: 150874 | Find: similardocuments

No.OrderlDand VendorMWFormulam/Z foundPurity MS FLI-06 1630-0135 ChemDiv 438.53C25H30N2O5 438 OK FLI-14 C329-0322 ChemDiv 512.61 C30H32N4O4 512OK FLI-15 C548-2756 Chem Div* 405.49 C17H19N5O3S2 405 OK FLI-19 4464-0971 ChemDiv 565.70C32H43N3O6 588 (M+Na+) OK FLI-20 STK164160 Vitas-M 383.51 C21H25N3O2S 438Impurity with M=438.6 F 4 (3) BAS00087237 Asinex 398.45 C22H26N2O5 398 OK F25(11) 1630-1646 ChemDiv 393.52 C25H31NO3 393 OK F 7 (4)OSSL_264545 Princeton Biomol. Res. 426.51 C24H30N2O5 426 OK F B (5) OSSK_158427Princeton Biomol. Res. 452.23 C26H32N2O5 452 OK *TheChemDiv entrycontains C15H19ClN4O5S3, MW=466.02; the correct structure was determined byNMR.

External link

Method for treating pain syndrome and other disorders

Jay Jie-Qiang Wu[US]

Publicationdate: 2017-12-05 | Patent publication No.: US-09834555-B2|Assignees: VM Therapeutics LLC. [US] | IPC: A61K31/519; C07D471/04; A61K31/4184; A61K31/498; C07D401/06; C07D513/04;A61K31/517; A61K9/00; A61K9/06 | Oldestpriority date: 2008-02-29 |Publicationdate: 2017-12-05

Score: 12.685205 | Text size: 107369 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

Sweet flavor modifier

CatherineTachdjian [US]; Xiao Qing Tang[US];Donald S.Karanewsky [US]; Guy Servant [US]; Xiaodong Li [US]; Feng Zhang [US]; Qing Chen [US];Hong Zhang [US]; Timothy JamesDavis [US];VincentDarmohusodo [US]; Melissa S. Wong[US];Victor Selchau[US]

Publicationdate: 2017-12-05 | Patent publication No.: US-09834544-B2|Assignees: Senomyx, Inc. [US] | IPC: C07D405/12; A23L2/60; C07D401/12; C07D215/54; C07D451/06; A61K47/22;C07D215/42; A23L27/00 | Oldestpriority date: 2011-08-12 | Publication date: 2017-12-05

Score: 10.928354 | Text size: 203955 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

METHODS OF TREATING MUSCULAR DYSTROPHY

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2017-11-30 | Patent publication No.: US-20170340606-A1|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THEUNIVERSITY OF NEVADA, [US] | IPC: A61K31/404; A61K45/06 | Oldestpriority date: 2013-03-15 |Publicationdate: 2017-11-30

Score: 10.354719 | Text size: 337339 | Find: similardocuments

et al.,2006). 2) DIVERSet library (Chembridge Corp., San Diego, Calif.) and compoundsfrom the ChemDivlibrary. 3) LOPAC library (Sigma-RPI) consists of1280 pharmaceutically active compounds.

COMPOSITIONS AND METHODS FOR INHIBITION OF AUTOPHAGY

Elizabeth J.Goldsmith [US]; Alexander T.Piala [US];Malia B. Potts[US]

Publicationdate: 2017-11-30 | Patent publication No.: US-20170340636-A1|Assignees: Board of Regents, The University of Texas System [US] | IPC: A61K31/517;A61K31/428; A61K31/427 | Oldestpriority date: 2016-05-26 | Publication date: 2017-11-30

Score: 14.165414 | Text size: 63081 | Find: similardocuments

These 13compounds were purchased from Chembridge Inc. and ChemDiv Inc. formeasurement of direct binding using Differential Scanning Fluorimetry (DSF).

Inhibitors of the notch signaling pathway and secretion for use inmedicine

ChristophKaether [DE]; AndreasKrämer [DE]

Publicationdate: 2017-11-28 | Patent publication No.: US-09828344-B2|Assignees: LEIBNIZ-INSTITUT FÜR ALTERSFORSCHUNG FRITZ-LIPMANN-INSTITUT E.V. (FLI)[DE] |IPC: C07D215/54 | Oldestpriority date: 2012-06-01 | Publication date: 2017-11-28

Score: 19.588453 | Text size: 140007 | Find: similardocuments

No.OrderIDand VendorMWFormulam/Z foundPurity MS FLI-06 1630-0135 ChemDiv 438.53C25H30N2O5 438 OK FLI-14 C329-0322 ChemDiv 512.81 C30H32N4O4512 OK FLI-15 C548-2756 ChemDiv* 405.49 C17H19N5O3S2 405 OK FLI-194464-0971 ChemDiv 565.70 C32H43N3O6 588 (M + Na+) OK FLI-20STK164160 Vitas-M 383.51 C21H25N3O2S 438 Impurity with M=438.6 FLI-24 (3)BAS00087237 Asinex 398.45 C22H26N2O5 398 OK FLI-25 (11) 1630-1646 ChemDiv 393.52C25H31NO3 393 OK FLI-27 (4) OSSL_264545 Princeton Biomol. Res. 426.51C24H30N2O5 426 OK FLI-28 (5) OSSK_158427 Princeton Biomol. Res. 452.23C26H32N2O5 452 OK *The ChemDiv entry contains C15H19CIN4O5S3,MW=466.02; the correct structure was determined by NMR.

Isolated human lung progenitor cells and uses thereof

JayarajRajagopal [US]; Hongmei Mou [US]

Publicationdate: 2017-11-28 | Patent publication No.: US-09828583-B2|Assignees: THE GENERAL HOSPITAL CORPORATION [US] | IPC:C12N5/074; A61K35/42; A61L27/38; A61L27/56; A61L27/58; G01N33/68;C12N5/071; A61K9/00 | Oldestpriority date: 2012-01-13 |Publicationdate: 2017-11-28

Score: 9.838301 | Text size: 266788 | Find: similardocuments

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive ChemistryLtdTM, ChemDiv, ChemBridgeTM, TimTec IncTM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING MICROBIOMEDYSREGULATIONS ASSOCIATED WITH CIRCADIAN CLOCK DISRUPTION

CHAMAILLARD,Mathias [FR]

Publicationdate: 2017-11-23 | Patent publication No.: WO-2017198847-A1|Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHEMÉDICALE) [FR]; UNIVERSITE DE LILLE 2 DROIT ET SANTE [FR]; UNIVERSITE DELILLE 1 SCIENCES ET TECHNOLOGIES [FR]; INSTITUT PASTEUR DE LILLE [FR]; CENTRENATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - [FR] | IPC: A61K31/277;A61K31/352; A61P43/00 | Oldestpriority date: 2016-05-20 | Publication date: 2017-11-23

Score: 13.793969 | Text size: 90391 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (SanDiego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, TheNetherlands), Timtec (Newark, DE), or alternatively can be

GENETIC ALTERATIONS ON CHROMOSOMES21Q, 6Q AND 15Q AND METHODS OF USE THEREOF FOR THE DIAGNOSIS AND TREATMENT OFTYPE I DIABETES

HAKONARSON,Hakon [US];GRANT, Struan[US];BRADFIELD,Jonathan [US]; POLYCHRONAKOS,Constantin [CA]; QU, Hui-Qi [CA]

Score: 13.327991 | Text size: 141303 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

External link

Method of screening for a compound for inhibitory activity of FN14-tweakinteraction

Nhan Tran [US]; Nathalie Meurice[US];Harshil Dhruv[US];Hongwei Yin [US]

Publicationdate: 2017-10-24 | Patent publication No.: US-09797882-B2|Assignees: The Translational Genomics Research Institute [US] |IPC: G01N33/50; A61K31/167; A61K31/53; A61K31/47; A61K31/635; A61K31/542;A61K31/433; A61K31/498; A61K31/437; A61K31/4045; A61K31/4155; A61K31/5513;A61K31/426; A61K31/55; A61K31/519; A61K31/422; A61K31/4192; A61K31/541;A61K45/06; A61K31/4188; A61K31/4704; A61K31/4745; A61K33/24 | Oldest priority date: 2013-07-09 | Publication date: 2017-10-24

Score: 18.078405 | Text size: 197671 | Find: similardocuments

implementedto identify virtual hits from a vendor compound library of peptidomimeticmolecules (ChemDiv, 13,637 compounds). ... The peptidomimetic setof ChemDiv (version of May 2011; 13,137 compounds) was preparedusing LigPrep version 2.5 in Schrodinger v2011 ... The peptidomimetic setof ChemDiv (13,137 compounds, v05.2011) was selected for thisstudy and pre-processed as described in methods. ... As shown in FIG. 10A, 4compounds from the supplier ChemDiv with compound identifiersG873-0032, F151-0435, D715-0890, and J004-1091 showed an average ... These coresubstructures served as query to perform a substructure search in the ChemDiv onlinecatalogue.

SMALL MOLECULE INHIBITORS OF HIV-1 ENTRY AND METHODS OF USE THEREOF

Joseph Sodroski [US]; Alon Herschhorn[US];Christopher Gu[US];Joel R. Courter[US];Mark Farrell[US];Amos B. Smith,III [US]

Publicationdate: 2017-10-19 | Patent publication No.: US-20170298056-A1|Assignees: Dana-Farber Cancer Institute, Inc. [US]; The Trustees of the University ofPennsylvania [US] | IPC: C07D417/12; C07D285/14 | Oldestpriority date: 2014-05-08 | Publication date: 2017-10-19

Score: 19.43171 | Text size: 132038 | Find: similardocuments

mg/mL BionetCEREP 4800 5 mg/mL CEREP ChemBridge3 10560 5 mg/mL ChemBridge ChemDiv1 26048 5mg/mL ChemDiv Chemical Diversity 2 8560 5 mg/mL ChemDiv ChemDiv316544 5 mg/mL ChemDivChemDiv4 14677 5 mg/mL ChemDiv ChemDiv51249 5 mg/mL ChemDiv ChemDiv6 44000 10 mM ChemDivEnamine1 6004 5 mg/mL Enamine Enamine 2 26576 5 mg/mL Enamine IFLab2 292 5 mg/mL IFLabLife ... 4576 5 mg/mL Maybridge Maybridge5 3212 5 mg/mL Maybridge Mixedcommercial plate 5 268 5 mg/mL ChemDivand Maybridge TABLE 2:Small-molecule screening data Category Parameter Description Assay Type of

Asthma susceptibility loci located at chromosome 1q31 for use indiagnostic and therapeutic methods

Hakon Hakonarson[US];Patrick M. A.Sleiman [US]

Publicationdate: 2017-10-17 | Patent publication No.: US-09790550-B2|Assignees: The Children's Hospital of Philadelphia [US] | IPC:C07H21/02; C07H21/04; C12Q1/68; C12P19/34 | Oldest priority date: 2008-05-16 | Publication date: 2017-10-17

Score: 13.556976 | Text size: 139851 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Small molecule activators of calcium-activated chloride channels andmethods of use

Alan S. Verkman[US];Wan Namkung [US]

Publicationdate: 2017-10-17 | Patent publication No.: US-09790218-B2|Assignees: The Regents of the University of California [US] | IPC:C07D417/12; A61K31/41; A61K31/426; A61K31/4439; C07D277/46 | Oldest priority date: 2011-08-05 | Publication date: 2017-10-17

Score: 15.5924425 | Text size: 147083 | Find: similardocuments

The compoundcollections used for screening included: ̃100,000 synthetic smallmolecules from ChemDiv (San Diego, Calif. ...Structure-activity analysis was done on analogs purchased from ChemDiv andAsinex.

Benzimidazole derivatives and uses thereof

Susan L.Lindquist [US]; Stephen L.Buchwald [US]; Daniel Tardiff[US];Nathan Jui [US]

Publicationdate: 2017-10-17 | Patent publication No.: US-09790188-B2|Assignees: Whitehead Institute for Biomedical Research [US]; Massachusetts Instituteof Technology [US] | IPC: C07D235/04; A61K31/4184; C07D235/16; A61K45/06; A61K31/4439; C07D235/08;C07D401/12; C07D403/04; C07D405/04; C07D409/12 | Oldest priority date: 2013-03-15 | Publication date: 2017-10-17

Score: 10.354719 | Text size: 276180 | Find: similardocuments

describedherein. [[image:EMI-C00079]] The original screen hit compound, ABI, waspurchased from ChemDiv(K783-0286). Subsequent synthesis wasperformed according to the following strategy.

Small molecules that replace or agonize p53 function

ShahroozRabizadeh [US]; Kayvan R. Niazi[US];Dale E. Bredesen[US]

Score: 17.493702 | Text size: 54980 | Find: similardocuments

Inhibitors of calcium-activated chloride channels

Alan S. Verkman[US];Ricardo De LaFuente Gonzalez [ES]

Publicationdate: 2017-10-17 | Patent publication No.: US-09789095-B2|Assignees: The Regents of the University of California [US] | IPC:A61K31/381; C07D333/50; A61K31/426; C07D277/42; C07D277/46; C07D333/68;C07D333/80; C07D409/12; G01N33/50; G01N33/84 | Oldest priority date: 2007-12-14 | Publication date: 2017-10-17

Score: 14.719831 | Text size: 205109 | Find: similardocuments

Compoundsfor primary screening were purchased from ChemDiv (San Diego,Calif. ... Compounds for the secondary screening were purchased from ChemDiv andAsinex.

DIRECT REPROGRAMMING OF SOMATIC CELLS INTO MYOGENIC CELLS

HOCHEDLINGER,Konrad [US];BAR-NUR, Ori[US]

Score: 12.484504 | Text size: 165107 | Find: similardocuments

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive ChemistryLtd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.

PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF

Daniel A.Lawrence [US]; Cory Emal [US]; Ashley Reinke[US];Shih-Hon Li [US]; Mark Warnock[US];GregoryAbernathy [US]

Publicationdate: 2017-10-12 | Patent publication No.: US-20170291893-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]; EASTERN MICHIGAN UNIVERSITY[US] |IPC: C07D417/10; C07C275/64; C07C235/80; C07C237/20; C07C243/26; C07D249/08;C07D277/34; C07D209/34; C07C311/48; C07C311/29; C07D207/48; C07D209/08;C07C311/37; C07C271/16; C07C235/34; C07C323/60; C07C69/94; C07D271/113 | Oldest priority date: 2012-10-31 | Publication date: 2017-10-12

Score: 11.918776 | Text size: 151482 | Find: similardocuments

ChemicalMethodologies Libraries Development (Boston University), Maybridge,Chembridge, ChemDiv, National Cancer Institute-Development TherapeuticsProgram Library, the Cayman Cannabinoid and

Indazole ureas and method of use

Jerome F. Daanen[US];David A. DeGoey[US];Jennifer M.Frost [US];John R. Koenig[US];Steve Latshaw[US];Mark Matulenko[US];Marc Scanio [US]; Lei Shi [CN]; William H.Bunnelle [US]

Publicationdate: 2017-10-10 | Patent publication No.: US-09783527-B2|Assignees: AbbVie Inc. [US] | IPC: A61K31/497; A61K31/4178; A61K31/4985; C07D403/04; C07D403/14; C07D487/14;C07D491/08; C07D413/14; C07D405/14; C07D417/14; C07D401/14 | Oldest priority date: 2014-09-16 | Publication date: 2017-10-10

Score: 8.94598 | Text size: 583224 | Find: similardocuments

was stirredat ambient temperature for 30 minutes, and then2-bromo-1-(pyrrolidin-1-yl)ethanone (ChemDiv, 2.33 g, 12.15 mmol) wasadded.

Highly potent inhibitors of porcupine

Lawrence Lum[US];Chuo Chen [US]

Publicationdate: 2017-10-10 | Patent publication No.: US-09783550-B2|Assignees: The Board of Regents of the University of Texas System [US] | IPC: A61K31/33;C07D495/04; A61K31/519; A61K45/06; A61N5/10 | Oldest priority date: 2013-05-14 | Publication date: 2017-10-10

Score: 13.327991 | Text size: 108128 | Find: similardocuments

four IWPlead compounds (1-4) were identified in the initial screen of 200,000 compounds(ChemDiv, ChemBridge, ComGenex, Prestwick and TimTek libraries) bearsimilar molecular skeletons (FIG. 1).

Oncogenic ROS1 and ALK kinase inhibitor

Xiao Jun Yao[CN];Lai Han Leung[CN];Lian Xiang Luo[CN];Liang Liu [CN]

Publicationdate: 2017-10-10 | Patent publication No.: US-09782400-B2|Assignees: Macau University of Science and Technology [MO] |IPC: A01N43/42; A61K31/444; A61K31/4745 | Oldest priority date: 2015-06-24 | Publication date: 2017-10-10

Score: 14.039395 | Text size: 79486 | Find: similardocuments

G341-0312was purchased from ChemDiv company.

Quinazolinone antibiotics

Mayland Chang[US];ShahriarMobashery [US]; Renee Bouley[US]

Publicationdate: 2017-10-03 | Patent publication No.: US-09776975-B2|Assignees: University of Notre Dame du Lac [US] | IPC:A61K31/517; C07D239/91; C07D401/06; C07D405/06; C07D471/04; A61K45/06;A61K31/43; A61K31/431; A61K31/545; A61K31/546; A61K31/7036; A61K31/7048;A61K31/519; A61K31/5377; C07D401/12 | Oldestpriority date: 2013-03-05 | Publication date: 2017-10-03

Score: 15.5924425 | Text size: 137196 | Find: similardocuments

X-raystructure of PBP-2a was used to screen by docking and scoring 1.2 millioncompounds from theChemDiv drug-like subset of the ZINC database insilico using multiple scoring functions (Autodock, Glide, ... A library of 1.2million drug-like compounds from the ChemDiv subset of theZINC database was prepared for high-throughput virtual screening against theX-ray

PYRAZOLES

Rudolf Schindler[DE];Hans-JoachimLankau [DE];NorbertHöfgen [DE]; ChristianGrunwald [DE]; Ute Egerland[DE];Barbara Langen[DE];Rita Dost [DE]; Thorsten Hage[DE];Simon Ward [GB]

Publicationdate: 2017-09-28 | Patent publication No.: US-20170275254-A1|Assignees: Janssen Pharmaceuticals, Inc. [US] | IPC:C07D231/12; A61K31/4155; A61K31/03; C07D403/06 | Oldest priority date: 2014-08-15 | Publication date: 2017-09-28

Score: 18.589487 | Text size: 149287 | Find: similardocuments

fromFluorochem, order ID: 313369 4-(chloroethyl)-3,5-dimethyl-1H-pyrazole,available from ChemDiv, order ID: BB01-43603-(chloromethyl)-1H-pyrazole hydrochloride, available from ChemDiv,order ID: BB20-2557 4-(chloromethyl)-1-ethyl-1H-pyrazole hydrochloride,available from ChemDiv, order ID: BB57-15495-(chloromethyl)-1-ethyl-1H-pyrazole hydrochloride, available from ChemDiv,order ID: BB57-3435 3-(chloromethyl)-1-cyclopentyl-1H-pyrazole, available fromEnamine, order ID: ... temperature for 20 minutes, then 4-(2-chloro-ethyl)-3,5-dimethyl-1H-pyrazole(159 mg, 1.0 mmol) (ChemDiv, BB01-4360) was added. The reaction mixturewas stirred at room temperature for 20 hours.

Antibacterial compounds

Francis XavierWilson [GB];Peter DavidJohnson [GB]; Richard Vickers[GB];Richard Storer[GB];Graham MichaelWynne [GB];Alan GeoffreyRoach [GB];Olivier De Moor[GB];Colin Richard Dorgan[GB];Paul James Davis[GB]

Score: 12.484504 | Text size: 138415 | Find: similardocuments

Vol. 26, No2, January 2006]. (ii) Commercial Compounds All compounds below were purchasedfromChemDiv:3,3′-(1H,1H-5,5′-Bibenzo[d]imidazole-2,2′-diyl)dianiline(Compound 2).

α-TRUXILLIC ACID DERIVATIVES ANDPHARMACEUTICAL COMPOSITIONS THEREOF

OJIMA, Iwao [US]; DEUTSCH, Dale[US];KACZOCHA, Martin[US];HU, Kongzhen[US];TONG, Simon [US]; ELMES, Matthew[US];YAN, Su [US]

Publicationdate: 2017-09-14 | Patent publication No.: WO-2017156354-A1|Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK [US] | IPC: C07C69/753;C07C69/757; C07C205/55; C07C233/25; C07D309/06; C07D249/06; A61K31/216;A61K31/35; A61K31/167; A61K31/4192; A61P43/00; A61P29/00 | Oldest priority date: 2016-03-11 | Publication date: 2017-09-14

Score: 13.10661 | Text size: 126222 | Find: similardocuments

Competitorsincluded arachidonic acid, BMS309403, 48 test compounds from ChemDiv library,Compound 26 and Compound 49.

Compounds that inhibit human DNA ligases and methods of treating cancer

Alan E.Tomkinson [US]; Helen Xi Chen[US];BarbaraDziegielewska [US]; Alexander D.Mackerell [US]; Shijun Zhong[US];Gerald M. Wilson[US]

Publicationdate: 2017-09-12 | Patent publication No.: US-09757375-B2|Assignees: University of Maryland, Baltimore [US] | IPC:A61K31/165; A61K31/505; C40B30/02; G06F19/16; A61K31/166; A61K31/255;A61N5/10; G01N21/64; G06F19/00; A61K31/397; C07D307/68; A61K31/175; A61K31/341;A61K31/404; A61K31/41; A61K31/4184; A61K31/423; A61K31/4245; A61K31/428;A61K31/433; A61K31/436; A61K31/4439; A61K31/495; A61K31/553; A61K45/06;C07D209/30; C07D235/28; C07D257/04; C07D263/58; C07D267/18; C07D271/12;C07D277/74; C07D285/14; C07D401/12; C07D407/12 | Oldest priority date: 2007-04-10 | Publication date: 2017-09-12

Score: 12.892465 | Text size: 150347 | Find: similardocuments

Compoundsidentified by CADD screening were purchased from ChemBridge, ChemDiv,MayBridge, MDD, Nanosyn, Specs, Timtec, and Tripos.

SMALL MOLECULE INHIBITORS OF PENDRIN ION EXCHANGE AND PHARMACEUTICALCOMPOSITIONS

VERKMAN, Alan,S., [US];HAGGIE, Peter[US];CIL, Onur [US]; VERKMAN, Alan,S., [US]

Publicationdate: 2017-08-31 | Patent publication No.: WO-2017147523-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/18;A61K31/4162; A61K31/4353 | Oldestpriority date: 2016-02-26 | Publication date: 2017-08-31

Score: 16.402758 | Text size: 96416 | Find: similardocuments

Screeningwas done with -36,000 compounds from ChemDiv (San Diego, CA),TimTec (Newark, DE), and Asinex (Winston-Salem, NC). ... PDSmh-COl was purchasedfrom ChemDiv (San Diego CA, USA). Other chemicals werepurchased from Sigma unless otherwise stated.

PROTEOSTASIS REGULATORS

Megan Foley [US]; Bradley Tait[US];Matthew Cullen[US]

Publicationdate: 2017-08-31 | Patent publication No.: US-20170247355-A1|Assignees: Proteostasis Therapeutics, Inc. [US] | IPC:C07D403/06; C07D207/337; C07D401/06; C07D295/185; C07D263/32; C07D275/02;C07D333/22; C07D249/06; C07D207/333; C07D231/12 |Oldest priority date: 2011-05-12 | Publicationdate: 2017-08-31

Score: 10.928354 | Text size: 236067 | Find: similardocuments

Compound A47(also shown below) was purchased from ChemDiv, San Diego, Calif.

Materials and method for inhibitingreplication protein A and uses thereof

John J. Turchi[US];Sarah Shuck [US]

Publicationdate: 2017-08-15 | Patent publication No.: US-09730942-B2|Assignees: Indiana University Research and Technology Corporation [US] | IPC: A01N43/00;A61K31/33; A61K31/5377; A61K31/4709; A61K9/00; A61K47/38; A61K47/26; A61K45/06|Oldestpriority date: 2010-02-05 | Publication date: 2017-08-15

Score: 18.390413 | Text size: 61791 | Find: similardocuments

EDCcoupling. [[image:EMI-C00007]] In Vitro Analysis Small molecule inhibitors wereobtained from ChemDivand resuspended in DMSO. ... A further studyundertook screening of a ChemDiv library using a fluorescencepolarization (FP) modification to the original assay (11). ... Eighty-oneanalogs were identified and obtained from the ChemDiv librarywith differing substitutions off the phenyl ring (R2) and varying substituentsat position

METHODS OF TREATING MUSCULAR DYSTROPHY

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2017-08-10 | Patent publication No.: US-20170224657-A1|Assignees: BOARD OF REGENTS OF NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OFUNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/404; A61K45/06 | Oldestpriority date: 2012-09-10 |Publicationdate: 2017-08-10

Score: 14.450268 | Text size: 217404 | Find: similardocuments

Methods for Identifying Subjects with a Genetic Risk for Developing IgANephropathy

Ali Gharavi [US]; KrzysztofKiryluk [US]; Richard Lifton[US]

Score: 12.484504 | Text size: 171801 | Find: similardocuments

SELECTIVE INHIBITORS OF CONSTITUTIVE ANDROSTANE RECEPTOR

Taosheng CHEN[US];Milu Cherian[US];Wenwei Lin [US]

Publicationdate: 2017-08-10 | Patent publication No.: US-20170226115-A1|Assignees: ST. JUDE CHILDREN'S RESEARCH HOSPITAL [US] |IPC: C07D487/08; C07D403/06; C07D401/06; C07D409/06; C07D403/14; C07D401/14;C07D413/14; C07D405/12; C07D223/28; C07D223/22 |Oldest priority date: 2014-10-20 | Publicationdate: 2017-08-10

Score: 11.501497 | Text size: 505716 | Find: similardocuments

Use of small molecule inhibitors targeting EYA tyrosine phosphatase

Rashmi Hegde[US]

Score: 11.239684 | Text size: 191306 | Find: similardocuments

L129305) andcompound 1b from ChemDiv (cat. no. 3039-0682).

ALPHA- AND GAMMA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICALCOMPOSITIONS THEREOF

Iwao Ojima [US]; Dale Deutsch[US];Martin Kaczocha[US];William T.Berger [US];Robert Rizzo[US];Trent E. Balius[US]

Publicationdate: 2017-08-03 | Patent publication No.: US-20170216241-A1|Assignees: The Research Foundation for The State University of New York [US] | IPC: A61K31/216;G01N33/68; A61K31/194 | Oldestpriority date: 2012-07-20 | Publication date: 2017-08-03

Score: 19.91218 | Text size: 138837 | Find: similardocuments

EnergeticallyDOCK selected ligands from the ChemDiv library that did nothave unfavorable interaction, both VDW and ES, intrinsically selecting ... Thefollowing compounds are available from ChemDiv (San Diego,Calif., USA): StructureChemDiv ID Number [[image:EMI-C00036]] 8009-2334[[image:EMI-C00037]] 8009-3434 [[image:EMI-C00038]] ... acid was from CaymanChemical (Ann Arbor, Mich.). 48 virtually screened test compounds from ChemDiv,Inc. (Moscow, Russia). ... Competitors included arachidonic acid,BMS309403, 48 test compounds from ChemDiv library, Compound 26and Compound 49. ... Virtual Screening A high-throughput virtual screening ofover one million molecules from the ChemDiv subset of the ZINCdatabase (http://zinc.docking.

Tunable control of protein degradation in synthetic and endogenousbacterial systems

Douglas EwenCameron [US]; James J. Collins[US]

Publicationdate: 2017-08-01 | Patent publication No.: US-09718858-B2|Assignees: TRUSTEES OF BOSTON UNIVERSITY [US] | IPC:A61K38/04; C07K5/00; C07K7/00; C07K16/00; C07K17/00; A61K38/06; C07K5/097;C07K14/30; G01N33/50; C07K5/083; C07K5/087; C07K5/09; C07K5/093; C07K5/103;C07K5/107; C07K5/11; C07K5/117; C07K7/06 | Oldest priority date: 2013-03-13 | Publication date: 2017-08-01

Score: 11.569273 | Text size: 266007 | Find: similardocuments

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive ChemistryLtd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.

Plasminogen activator inhibitor-1 inhibitors and methods of use thereof

Daniel A.Lawrence [US]; Cory Emal [US]; Ashley Reinke[US];Shih-Hon Li [US]; Mark Warnock[US];GregoryAbernathy [US]

Publicationdate: 2017-08-01 | Patent publication No.: US-09718760-B2|Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]; EASTERN MICHIGAN UNIVERSITY[US] |IPC: C07C243/26; C07C69/84; C07C259/06; C07C271/16; C07C275/64; C07C311/17;C07C311/29; C07C311/48; C07C311/49; C07D417/04; C07C323/60; C07D249/08;C07C233/13; C07C233/56; C07D261/18; C07C235/34; C07C235/46; C07D271/113;C07D277/34; C07D207/48; C07C251/76; C07D209/08; C07D209/34; C07D213/42 | Oldest priority date: 2012-10-31 |Publicationdate: 2017-08-01

Score: 12.290053 | Text size: 162691 | Find: similardocuments

ChemicalMethodologies Libraries Development (Boston University), Maybridge,Chembridge, ChemDiv, National Cancer Institute-DevelopmentTherapeutics Program Library, the Cayman Cannabinoid and

Vacuolin-1 as an inhibitor of autophagy and endosomal trafficking and theuse thereof for inhibiting tumor progression

Jianbo Yue [CN]; Yingying Lu [CN]

Publicationdate: 2017-08-01 | Patent publication No.: US-09717737-B2|Assignees: THE UNIVERSITY OF HONG KONG [CN] | IPC:A61K31/535;A61K31/5377; A61K31/337; A61K31/436; A61K31/513 | Oldest priority date: 2014-02-19 | Publication date: 2017-08-01

Score: 14.831028 | Text size: 48155 | Find: similardocuments

FIG. 14shows a virtual screening strategy for vacuolin-1 analogue identificationusing ChemDiv.

ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME

Dan THEODORESCU[US];MichaelFitzpatrick WEMPE [US]; David ROSS [US]; Chao YAN [US]; Phillip REIGAN[US]

Publicationdate: 2017-07-20 | Patent publication No.: US-20170204112-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate [US] | IPC: C07D491/052;A61K31/4162; A61K45/06 | Oldestpriority date: 2014-07-10 | Publication date: 2017-07-20

Score: 11.918776 | Text size: 143190 | Find: similardocuments

The ChemDiv library[v2006.

SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY

Alan D. D'Andrea[US];Gregory D. Cuny[US];Ross L. Stein[US];Marcie Glicksman[US];April Case [US]; Jun Xian [US]; David Wilson[US];Min Huang [CN]

Publicationdate: 2017-07-20 | Patent publication No.: US-20170202810-A1|Assignees: Dana-Farber Cancer Institute, Inc. [US]; The Brigham and Women's Hospital,Inc. [US] | IPC: A61K31/423 | Oldestpriority date: 2010-04-30 | Publication date: 2017-07-20

Score: 11.239684 | Text size: 179384 | Find: similardocuments

consists ofknown bioactive libraries, natural product libraries, and commercial librariessuch as ChemDiv, ChemBridge, etc.

Methods of treating muscular dystrophy

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2017-07-18 | Patent publication No.: US-09707210-B2|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THEUNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/404; A61K45/06 | Oldestpriority date: 2013-03-15 | Publication date: 2017-07-18

Score: 10.354719 | Text size: 365566 | Find: similardocuments

et al.,2006). 2) DIVERSet library (Chembridge Corp., San Diego, Calif.) and compoundsfrom the ChemDivlibrary. 3) LOPAC library (Sigma-RPI) consists of1280 pharmaceutically active compounds.

Compounds, compositions, and methods for reducing or eliminating bittertaste

Francis XavierBrennan [US]; William P. Jones[US];Jane V. Leland[US];David Hayashi[US]

Publicationdate: 2017-07-18 | Patent publication No.: US-09706790-B2|Assignees: CHROMOCELL CORPORATION [US] | IPC: A23L29/00; A23L27/30; A23L33/00; A23L27/40; A23L27/00; A23L13/00; A23L5/20;A23L1/22 | Oldestpriority date: 2011-10-20 | Publication date: 2017-07-18

Score: 11.239684 | Text size: 195943 | Find: similardocuments

may beobtained from commercial vendors for synthetic and natural compounds, such asVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

MUCOADHESIVE DEVICES FOR DELIVERY OF ACTIVE AGENTS

Publicationdate: 2017-07-13 | Patent publication No.: US-20170196800-A1|Assignees: ENTREGA INC. [US]; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K9/00; A61K38/23;A61K9/20; A61K38/28 | Oldestpriority date: 2012-06-14 | Publication date:2017-07-13

Score: 12.685205 | Text size: 121248 | Find: similardocuments

fromcommercial and academic sources, for example, from Sigma-Aldrich(www.sigmaaldrich.com), ChemDiv(www.chemdiv.com), Evotec(www.evotec.com or ICCB (iccb.med.harvard.

COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS

WU, JayJie-qiang [US]; WANG, Ling [US]

Publicationdate: 2017-07-05 | Patent publication No.: EP-2194783-B1|Assignees: VM Discovery, Inc. [US] | IPC: C07D403/12; C07D401/14; C07D215/56; C07D401/06; C07D401/10; C07D401/12;C07D403/06; C07D413/12; C07D405/12; C07D413/10; C07D417/10; C07D417/12;C07D249/18; C07D471/04; C07D251/54; C07D487/04; C07D487/08; C07D491/048;C07D491/107; C07D495/04; C07D491/113 |Oldest priority date: 2008-04-21 | Publicationdate: 2017-07-05

Score: 11.918776 | Text size: 150641 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (SanDiego, CA), ChemDiv (San Diego, CA), SPECS (Delft, TheNetherlands), Timtec (Newark, DE) or can be synthesized.

External link

Sweet flavor modifier

Sara Adamski-Werner[US];VincentDarmohusodo [US]; CatherineTachdjian [US]; DonaldKaranewsky [US]; Goran Petrovic[US];Rachel Kimmich[US];Joseph R.Fotsing [US]

Publicationdate: 2017-07-04 | Patent publication No.: US-09695162-B2|Assignees: Senomyx, Inc. [US] | IPC: C07D417/14; C07D417/12; C07D471/04; C07D473/00; C07D498/04; A23L27/20;A23L33/15 | Oldestpriority date: 2013-02-19 | Publication date: 2017-07-04

Score: 11.569273 | Text size: 221686 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

SWEET FLAVOR MODIFIER

CatherineTachdjian [US]; DonaldKaranewsky [US]; Sara Werner [US]; VincentDarmohusodo [US]; Jeff Yamamoto[US]

Score: 10.928354 | Text size: 221535 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USESTHEREOF

John J. Turchi[US];Sarah Shuck [US]

Publicationdate: 2017-06-29 | Patent publication No.: US-20170182055-A1|Assignees: Indiana University Research and Technology Corporation [US] | IPC: A61K31/5377;A61K45/06; A61K47/38; A61K47/26; A61K31/4709; A61K9/00 | Oldest priority date: 2010-02-05 |Publicationdate: 2017-06-29

Score: 18.390413 | Text size: 57656 | Find: similardocuments

EDCcoupling. [[image:EMI-C00008]] In Vitro Analysis Small molecule inhibitors wereobtained from ChemDivand resuspended in DMSO. ... A further studyundertook screening of a ChemDiv library using a fluorescencepolarization (FP) modification to the original assay (11). ... Eighty-oneanalogs were identified and obtained from the ChemDiv librarywith differing substitutions off the phenyl ring (R2) and varying substituentsat position

CFTR REGULATORS AND METHODS OF USE THEREOF

VERKMAN, Alan[US];LEVIN, Marc, H.[US];CIL, Onur [US]

Publicationdate: 2017-06-29 | Patent publication No.: WO-2017112947-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: C07K5/078;C07K5/062; C07D285/135 | Oldestpriority date: 2015-12-24 | Publication date: 2017-06-29

Score: 15.53077 | Text size: 440344 | Find: similardocuments

was doneusing a diverse collection of 120,000 drug-like synthetic compounds obtainedfrom ChemDiv Inc.(San Diego, California, USA) and Asinex(Winston-Salem, North Carolina, USA). For structure-activity analysis, 600commercially available analogs (ChemDiv Inc.) of active compoundsidentified in the primary screen were tested. ... was done using a diversecollection of 120,000 drug-like synthetic compounds obtained fromChemDivInc. (San Diego, California, USA) and Asinex (Winston-Salem, NorthCarolina, USA). For structure-activity analysis, 600 commercially availableanalogs (ChemDiv Inc.) of active compounds identified in the primaryscreen were tested.

CFTR REGULATORS AND METHODS OF USE THEREOF

VERKMAN, Alan[US];LEVIN, Marc, H.[US];CIL, Onur [US]; LEE, Sujin [US]

Publicationdate: 2017-06-29 | Patent publication No.: WO-2017112951-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: C07D251/70;C07D251/50; C07D251/44 | Oldestpriority date: 2015-12-24 | Publication date: 2017-06-29

Score: 14.397283 | Text size: 592136 | Find: similardocuments

COMPOSITIONS AND METHODS FORTREATMENT OF LEUKEMIA

HESS, Jay [US]; GREMBECKA,Jolanta [US]; CIERPICKI,Tomasz [US]

Publicationdate: 2017-06-14 | Patent publication No.: EP-2473054-B1|Assignees: The Regents of the University of Michigan [US]; University of VirginiaPatent Foundation [US] | IPC: A61K31/519; A61P35/00 | Oldestpriority date: 2009-09-04 | Publication date: 2017-06-14

Score: 20.573181 | Text size: 70372 | Find: similardocuments

in FP assaywith FLSN-MLL (μM)Vendor/Cat#IC50 in HTRF assay (μM) Compound32 [[image:ib0068]] 13ChemDiv Inc. Cat # 4780-0051 7 Compound 33 [[image:ib0069]]29 ChemDiv Inc. Cat # 5742-0717 28 Compound 34[[image:ib0070]] 12 ChemDiv Inc. Cat # 3393-0109 ND Compound35 [[image:ib0071]] 35ChemDiv Inc. Cat # 3393-0126 ND Compound 36[[image:ib0072]] 63 ChemDiv Inc. Cat # 3170-5216 ND Compound37 [[image:ib0073]] 100 ChemDiv Inc. Cat # 3404-5359 NDCompound 38 [[image:ib0074]] 115 ChemBridge Cat # 6369841 ND Compound 39[[image:ib0075]] 230 ChemDiv Inc. Cat # 3170-5232 ND Compound40 [[image:ib0076]] NA ChemDiv Inc. Cat # 5531-8211 NDCompound 41 [[image:ib0077]] NAChemDiv Inc. Cat # 3770-0060 NDCompound 84 [[image:ib0078]] 100 Interbioscree n STOCK2S-89112 ND Compound 85

External link

Yeast cells expressing amyloid beta and uses therefor

Kent E. S.Matlack [US]; Susan L.Lindquist [US]; SebastianTreusch [US]

Score: 14.039395 | Text size: 79481 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Anti-depression Compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]; Jeffrey M.Zigman [US]

Publicationdate: 2017-06-08 | Patent publication No.: US-20170157092-A1|Assignees: Board of Regents of the University of Texas System [US] | IPC: A61K31/4045;A61K31/422; A61K31/506; A61K31/4192; A61K31/5377; A61K31/429; A61K31/69;A61K31/4188; A61K31/41; A61K31/4439; A61K31/4155 | Oldest priority date: 2009-01-09 | Publication date: 2017-06-08

Score: 17.703602 | Text size: 739755 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 60.1-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00139]] This compound can be purchased from ChemDiv, Inc.Example61. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00140]] This compound can be purchased from ChemDiv, Inc. Example62. 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol [[image:EMI-C00141]]This compound can be purchased from ChemDiv, Inc. Example 63.1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00142]] This compound can be purchased from ChemDiv, Inc. Example64.

MATERIALS FOR CATHEPSIN B ENHANCEMENT AND METHODS OF USE

BAHR, Ben, A.[US];BAHR, Ben, A.[US]

Score: 12.685205 | Text size: 112903 | Find: similardocuments

Z-Phe-Pro-OHis commercially available from ChemDiv Inc. (San Diego, CA,USA).

CELLULAR DISCOVERY PLATFORM FOR NEURODEGENERATIVE DISEASES

Susan L.Lindquist [US]; Vikram Khurana[US];Chee-Yeun Chung[US]

Score: 7.2924438 | Text size: 554894 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

SCREENING METHODS FOR THE BINDING AFFINITY OF CHEMICAL ENTITIES TOBIOLOGICAL MOLECULES AND NEDD4-1 INHIBITORS IDENTIFIED BY THE SCREENING METHODS

Alexander V.Statsyuk [US]; Stefan G.Kathman [US]

Publicationdate: 2017-06-01 | Patent publication No.: US-20170152228-A1|Assignees: Northwestern University [US] | IPC: C07D209/42; C07D231/56; C07D307/84; C07D471/04; C12Q1/25; C07C235/40 | Oldest priority date: 2017-02-09 | Publication date: 2017-06-01

Score: 11.918776 | Text size: 185690 | Find: similardocuments

fromAccelrys, 94,275 commercially available carboxylic acids were identified fromthe ChemBridge, ChemDiv, MayBridge, NCI and Sigma-Aldrich librariesusing SMARTS query strings.

Lipid containing formulations

MuthiahManoharan [US]; KallanthottathilG. Rajeev [US]; Akin Akinc [US]; Jayaprakash K.Nair [US];MuthusamyJayaraman [US]; Martin Maier[US]

Publicationdate: 2017-05-30 | Patent publication No.: US-09663449-B2|Assignees: ARBUTUS BIOPHARMA CORPORATION [CA] | IPC:A61K9/48; C07C229/00; A61K9/127; A61K47/34; C07C233/36; C07C209/78;C07C219/06; A61K31/325; C07C271/10; C07C323/25 | Oldest priority date: 2006-10-03 | Publication date: 2017-05-30

Score: 10.354719 | Text size: 282954 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet, Camelford,England; ChemDiv, SanDiego, Calif.

Targeting human thymidylate kinase induces DNA repair toxicity inmalignant tumor cells

Zee-Fen Chang[TW];Jim-Min Fang[TW]

Publicationdate: 2017-05-30 | Patent publication No.: US-09662328-B2|Assignees: NATIONAL YANG-MING UNIVERSITY [TW]; NATIONAL TAIWAN UNIVERSITY [TW] | IPC: A61K31/496;C07D513/04; A61K31/704; C07D519/00; C07D275/04; C07F7/18; A61K31/695; C07D417/04|Oldest priority date: 2010-11-29 | Publication date: 2017-05-30

Score: 11.239684 | Text size: 195206 | Find: similardocuments

2010) wasmodified and used to screen 21,120 structurally diversified compounds selectedfrom ChemDivlibrary (San Diego, USA).

STING AGONISTS AND METHODS OF SELECTING STING AGONISTS

VictorDeFilippis [US]; Tina Sali [US]; Kara Pryke [US]; Jinu Abraham[US];Andrew Liu [US]; Iris Archer [US]; Kayla Sheridan[US];Aaron Nilsen[US];Rebecca Broeckel[US];Jessica Smith[US];Lisi Amsler [US]; Daniel Streblow[US];Andrew Placzek[US]

Score: 12.484504 | Text size: 120821 | Find: similardocuments

Stocks ofG10 were purchased from ChemDiv.

LIN28/LET-7 CRYSTAL STRUCTURES, PURIFICATION PROTOCOLS, AND MOLECULARPROBES SUITABLE FOR SCREENING ASSAYS AND THERAPEUTICS

Piotr SLIZ [US]; Yunsun NAM [US]

Score: 10.354719 | Text size: 290557 | Find: similardocuments

2, Prestwick2 Collection, MSDiscovery 1, Biomol ICCB Know Bioactives, Asinex 1, ChemBridge3, ChemDiv 4 and 6, Life Chemicals 1, and Maybridge 4 and 5.These libraries can be screened using the

Methods and compositions for identifying and validating modulators ofcell fate

Kambiz Shekdar[US];Dennis J.Sawchuk [US]; Jessica C.Langer [US]

Publicationdate: 2017-05-23 | Patent publication No.: US-09657357-B2|Assignees: CHROMOCELL CORPORATION [US] | IPC: C12P21/02; C12N15/85; C12Q1/68; G01N33/50; C12N5/07; C12N15/00 | Oldest priority date: 2009-07-31 | Publication date: 2017-05-23

Score: 10.633806 | Text size: 268004 | Find: similardocuments

Non-limitingexamples of small molecule libraries include LOPAC, TimTec, ChemDiv,Asinex and Ryan Scientific.

PDE-DELTA INHIBITOR FOR THE TREATMENT OF CANCER

Xiao Jun Yao[CN];Lai Han Leung[CN];Lian Xiang Luo[CN];Liang Liu [CN]

Score: 14.557414 | Text size: 62841 | Find: similardocuments

Compound ofFormula (VII), i.e. 3237-1526, was purchased from ChemDiv company.

RECOMBINANT RSV REPORTER VIRUS

Richard K.Plemper [US]; Dan Yan [US]

Score: 16.234026 | Text size: 128620 | Find: similardocuments

Corporation(16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA,www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, SanDiego, Calif. ... The screening library was obtained from ChemDiv.

Modulators of GTPase and use in relevant treatment

AngelaWandinger-Ness [US]; Larry Sklar [US]; Zurab Surviladze[US];Tudor Oprea [US]; Laurie Hudson[US];Jeffrey Aube[US];Jennifer E.Golden [US];Chad E.Schroeder [US]; Denise S.Simpson [US]; Julica J. Noth[DE]

Publicationdate: 2017-05-09 | Patent publication No.: US-09642835-B2|Assignees: STC.UNM [US]; UNIVERSITY OF KANSAS [US] | IPC:A61K31/415; A61K45/06; C07D231/06; A61K31/403; A61K31/407 | Oldest priority date: 2010-06-17 | Publication date: 2017-05-09

Score: 12.484504 | Text size: 149742 | Find: similardocuments

In total1243 compounds were tested in dose response assays based on both MLSMRand ChemDiv virtual screening.

Methods for maturing cardiomyocytes and uses thereof

HanneleRuohola-Baker [US]; KavithaKuppusamy [US]; Henrik Sperber[US]

Publicationdate: 2017-04-18 | Patent publication No.: US-09624471-B2|Assignees: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION [US] | IPC: C12N5/16;C12N5/22; C12N15/06; C12N15/07; C12N15/113; A61K35/44; A61K48/00; C12N5/077;C12N15/11; A61K35/34 | Oldestpriority date: 2013-06-12 | Publication date: 2017-04-18

Score: 11.918776 | Text size: 202704 | Find: similardocuments

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive Chemistry Ltd.TM, ChemDiv,ChemBridgeTM, TimTec Inc.TM, AsisChemTM, and Princeton Biomolecular ResearchTM,among others.

Compounds for treating pruritic conditions

Amale Hawi [US]

Score: 13.327991 | Text size: 97072 | Find: similardocuments

other well knownchemical suppliers such as Fisher Scientific, TCI America of Philadelphia,Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego,Calif.

COMPOUNDS AND METHODS FOR PROMOTING STRESS RESISTANCE

CREGG, James[US];KENYON, Cinthia[US];ZHANG, Peichuan[US];ANG, Kean-hooi[US];ARKIN, Michael[US];CREGG, James[US]

Publicationdate: 2017-04-13 | Patent publication No.: WO-2017062751-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: C12Q1/68;A23L33/10; A61P35/00; G01N33/15 | Oldestpriority date: 2015-10-08 | Publication date: 2017-04-13

Score: 7.874651 | Text size: 591535 | Find: similardocuments

a"diversity library" that contains 104, 121 small molecules (~24K fromChemBridge; ~50K from ChemDiv; and ~30K from SPECS) selected tomaximize the coverage of chemical space.

Anti-depression compounds

Steven L.McKnight [US]; Andew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]; Jeffrey M.Zigman [US]

Publicationdate: 2017-04-11 | Patent publication No.: US-09616048-B2|Assignees: Board of Regents of The University of Texas System [US] | IPC: A61K31/44;A61K31/403; A61K31/4439; A61K31/4045; C07D209/04; C07D209/82; C07D401/06;C07D413/06; C07D471/04; C07D403/12; C07D403/06; C07F5/02; C07D487/04;A61K31/404; A61K31/4155; A61K31/4192; A61K31/422; A61K31/437; A61K31/4425;A61K31/506; C07D413/14; C07D401/12; C07D403/14; C07D407/06; C07D209/88;C07D405/12; C07D495/04; C07D209/08; C07D209/86; C07F7/08; A61K31/4188 | Oldest priority date: 2009-01-09 | Publication date: 2017-04-11

Score: 17.703602 | Text size: 778884 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00139]] This compound can be purchased from ChemDiv, Inc.Example61 1-(3,6-dibromo-9H-carbazol-9-yl)-3(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00140]] This compound can be purchased from ChemDiv, Inc. Example62 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol [[image:EMI-C00141]]This compound can be purchased from ChemDiv, Inc. Example 631-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00142]] This compound can be purchased from ChemDiv, Inc. Example

CARBOXAMIDE INHIBITORS

Luca ARISTA [CH]; Simona COTESTA[CH];PierD'ALESSANDRO [CH]; Anne-MarieEDWARDS [GB]; Rene LATTMANN[CH];Dimitrios LIZOS[CH];Robert AlexanderPULZ [CH];Lisa Ann ROONEY[GB];Nichola SMITH[US];Jessica LouiseTAYLOR [GB];Thomas J.TROXLER [CH]

Score: 15.290299 | Text size: 176286 | Find: similardocuments

(registrynumber 688050-41-1; Library: ChemDiv. ... (registry number912760-79-3; Library: ChemDiv.

IDENTIFICATION OF COMPOUNDS THAT DISPERSE TDP-43 INCLUSIONS

Benjamin Wolozin[US];Marcie Glicksman[US];Gregory D. Cuny[US];Justin Boyd [US]

Publicationdate: 2017-03-30 | Patent publication No.: US-20170088515-A1|Assignees: AQUINNAH PHARMACEUTICALS, INC. [US]; THE BRIGHAM AND WOMEN'S HOSPITAL, INC.[US] |IPC: C07D207/36; C07D401/12; C07D211/34; C07D487/04; C07D215/36; G01N33/50;C07D211/26; C07D211/52; C07D239/94; C07D215/227; C07D403/06; C07D417/04;C07D239/52 | Oldestpriority date: 2011-05-20 |Publicationdate: 2017-03-30

Score: 15.290299 | Text size: 173409 | Find: similardocuments

Exemplaryembodiments of compounds of formulas (I)-(VI) may be obtained commerciallyfrom ChemDiv (San Diego, Calif.; http://us.chemdiv.com),ChemBridge (San Diego, Calif.; http://www.chembridge. ... C279-0807) are available from ChemDiv.

COMPOSITIONS AND METHODS FOR USE INCOMBINATION FOR THE TREATMENT AND DIAGNOSIS OF AUTOIMMUNE DISEASES

HAKONARSON,Hakon [US];LI, Yun, Rose[US];KEATING, Brendan[US]

Score: 9.838301 | Text size: 317517 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia),ChemStar (Moscow, Russia), Exclusive

COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN ANDOTHER DISEASES

WU, JayJie-Qiang [US]

Publicationdate: 2017-03-01 | Patent publication No.: EP-3135672-A1|Assignees: VM Discovery, Inc. [US] | IPC: C07D401/14; C07D401/02; C07D279/14; C07D241/40; C07D487/04; C07D265/36;C07D498/04; A61K31/4162; A61P35/00 | Oldestpriority date: 2008-10-10 | Publication date: 2017-03-01

Score: 10.633806 | Text size: 248344 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (SanDiego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, TheNetherlands), Timtec (Newark, DE) or can be synthesized.

External link

Methods and Pharmaceutical Compositions for the Treatment of DiseasesMediated by the NRP-1/OBR Complex Signaling Pathway

ZakiaBelaid-Choucair [FR]; Olivier Hermine[FR];CarmenGarrido-Fleury [FR]; Claude Cochet[FR];OdileFilhol-Cochet [FR]; RenaudSeigneuric [FR]

Publicationdate: 2017-02-23 | Patent publication No.: US-20170051062-A1|Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale) [FR];Universite Paris Descartes [FR]; Fondation Imagine [FR]; AssistancePublique-Hopitaux de Paris (APHP) [FR]; Centre National de la RechercheScientifique (CNRS) [FR]; Universite Grenoble Alpes [FR]; Commissariat al'Energie Atomique et aux Energies Alternatives [FR]; Universite de Bourgogne[FR] |IPC: C07K16/28; A61K39/395; G01N33/566; A61K31/7105; A61K31/713; A61K45/06;C12N15/113 | Oldestpriority date: 2014-02-18 | Publication date: 2017-02-23

Score: 11.918776 | Text size: 144308 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

Compositions and Methods for Use in Combination for the Treatment andDiagnosis of Autoimmune Diseases

Hakon Hakonarson[US];Yun Rose Li [US]; Brendan Keating[US]

Score: 9.370946 | Text size: 361002 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Methods of Treating Autoimmune Conditions in Patients with GeneticVariations in DCR3 or in a DCR3 Network Gene

Hakon Hakonarson[US];Charlly Kao [US]; ChristopherCardinale [US]; Rahul Pandey[US];Yun Rose Li [US]

Score: 12.290053 | Text size: 158524 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Methods for Producing Enteroendocrine Cells That Make and Secrete Insulin

Chutima Talchai[US];Domenico Accili[US]

Publicationdate: 2017-02-16 | Patent publication No.: US-20170044532-A1|Assignees: The Trustees Of Columbia University In The City Of New York [US] | IPC: C12N15/113;C12N5/071; G01N33/50 | Oldestpriority date: 2010-05-12 | Publication date: 2017-02-16

Score: 11.239684 | Text size: 181544 | Find: similardocuments

Methods of treating muscular dystrophy

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2017-02-14 | Patent publication No.: US-09566310-B2|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THEUNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/16; A01N37/18; A61K31/415; A61K38/05; A61K31/343; A61K31/4418;A61K31/444; A61K31/4709; A61K31/53; A61K31/5375; A61K31/5377; A61K31/5383;A61K31/551; A61K31/57; A61K31/661; A61K45/06; A61K31/20; A61K31/4178;A61K31/5365; A61K31/575; A61K38/39; A61K31/19; A61K31/277; A61K31/341;A61K31/36; A61K31/37; A61K31/381; A61K31/4025; A61K31/4035; A61K31/41;A61K31/4196; A61K31/421; A61K31/426; A61K31/4365; A61K31/4402; A61K31/47; A61K31/473;A61K31/496; A61K31/498; A61K31/4985; A61K31/506; A61K31/519; A61K31/541 | Oldest priority date: 2012-09-10 |Publicationdate: 2017-02-14

Score: 14.450268 | Text size: 242294 | Find: similardocuments

In vivo cellular screening methods and compositions for modeling andtreating nervous system dysfunction

Barry Ganetzky[US];Daniel L. Miller[US];Shannon L.Ballard [US]

Publicationdate: 2017-02-14 | Patent publication No.: US-09568468-B2|Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION [US] |IPC: G01N33/00; A01K67/00; G01N33/50; G01N33/68 | Oldest priority date: 2013-03-15 | Publication date: 2017-02-14

Score: 13.327991 | Text size: 121267 | Find: similardocuments

DiscoverySystems, Inc. (Gaylordsville, Conn.); ChemBridge Corporation (San Diego,Calif.); and ChemDiv Inc.(San Diego, Calif.

Compositions and methods for inhibiting norovirus infection

Xi Jiang [US]; Ming Tan [US]; Xufu Zhang [CN]

Publicationdate: 2017-02-07 | Patent publication No.: US-09561239-B2|Assignees: Children's Hospital Medical Center [US] | IPC:A61K31/56; A61K31/57; C07J41/00; C07J7/00; C07J9/00; C07J3/00; A61K31/568;A61K31/575 | Oldestpriority date: 2013-07-12 | Publication date: 2017-02-07

Score: 14.039395 | Text size: 112530 | Find: similardocuments

Molport(http://www.molport.com) supplied by Maybridg, TimTec, ChemBridge, Pharmeks,Specs, Otava,ChemDiv, InterBioScreen Ltd, Vitas-M Laboratory, PrincetonBiomolecular Research and Enamine Ltd.

SWEET FLAVOR MODIFIER

SaraAdamski-Werner [US]; VincentDarmohusodo [US]; CatherineTachdjian [US]; DonaldKaranewsky [US]; Goran Petrovic[US];Rachel Kimmich[US];Joseph R.Fotsing [US]

Publicationdate: 2017-02-02 | Patent publication No.: US-20170029416-A1|Assignees: SENOMYX, INC. [US] | IPC: C07D417/12; A23L27/20; C07D473/00; C07D498/04; C07D417/14; C07D471/04 | Oldest priority date: 2013-02-19 | Publication date: 2017-02-02

Score: 11.569273 | Text size: 192755 | Find: similar documents

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

Proteostasis regulators

Megan Foley [US]; Bradley Tait[US];Matthew Cullen[US]

Publicationdate: 2017-01-31 | Patent publication No.: US-09556166-B2|Assignees: Proteostasis Therapeutics, Inc. [US] | IPC:C07D401/06; C07D403/06; C07D405/06; C07D471/04; C07D207/333; C07D207/337;C07D231/12; C07D249/06; C07D263/32; C07D275/02; C07D295/185; C07D333/20 | Oldest priority date: 2011-05-12 | Publication date: 2017-01-31

Score: 11.569273 | Text size: 218842 | Find: similar documents

Compound A47(also shown below) was purchased from ChemDiv, San Diego, Calif.

ASSOCIATION OF RARE RECURRENT GENETIC VARIATIONS TO ATTENTION-DEFICIT,HYPERACTIVITY DISORDER (ADHD) AND METHODS OF USE THEREOF FOR THE DIAGNOSIS ANDTREATMENT OF THE SAME

Joseph Glessner[US];Josephine Elia[US];Hakon Hakonarson[US]

Score: 10.354719 | Text size: 248856 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Antimicrobial potentiators

Timothy J.Opperman [US]; Son T. Nguyen[US];Steven M. Kwasny[US];Xiaoyuan Ding[US]

Publicationdate: 2017-01-10 | Patent publication No.: US-09540389-B2|Assignees: Microbiotix, Inc. [US] | IPC: A61K31/5377; C07D491/052; A61K31/551; C07D493/04; C07D513/04; A61K45/06;A61K31/436; A61K31/496; A61K31/541; A01N43/90; A01N47/44; A61K31/5383;A61K31/553 | Oldestpriority date: 2013-05-03 | Publication date: 2017-01-10

Score: 11.569273 | Text size: 164783 | Find: similardocuments

librariesused in high-throughput screens were purchased from Chembridge (San Diego,Calif.), ChemDiv (San Diego, Calif.), and TimTec (Newark, Del.).MBX2319 was synthesized by Microbiotix, Inc.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OR ELIMINATING BITTERTASTE

Kambiz Shekdar[US];Daniel Lavery[US];Joseph Gunnet[US];Jessica Langer[US];Jane V. Leland[US];David Hayashi[US];Peter H. Brown[US];Louise Slade[US];William P. Jones[US]

Publicationdate: 2017-01-05 | Patent publication No.: US-20170000178-A1|Assignees: Chromocell Corporation [US]; Kraft Foods Group Brands LLC [US] | IPC: A23L27/00;A61K47/12; A61K47/14; A23L27/20; A61K47/02 | Oldest priority date: 2010-04-15 | Publication date:2017-01-05

Score: 8.557886 | Text size: 381502 | Find: similardocuments

wereobtained from commercial vendors for synthetic and natural compounds, includingVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

Materials and method for inhibiting replication protein A and usesthereof

John J. Turchi[US];Sarah Shuck [US]

Publicationdate: 2017-01-03 | Patent publication No.: US-09533969-B2|Assignees: Indiana University Research and Technology Corporation [US] | IPC: A01N43/00;A61K31/33; C07D401/04; A61K31/415; A61K31/4709; A61K31/5377; A61K33/24;A61K45/06 | Oldestpriority date: 2010-02-05 | Publication date: 2017-01-03

Score: 18.390413 | Text size: 60495 | Find: similardocuments

Inhibition of human immunodeficiency virus integrase reaching dimerformation utilizing single-chain variable antibodies

Anna MarieSkalka [US];Mark Andrake[US];Ravi ShankarBojja [US]

Publicationdate: 2017-01-03 | Patent publication No.: US-09533040-B2|Assignees: Institute for Cancer Research [US] | IPC: C12Q1/34;C07K16/10; A61K39/395; C12Q1/18; C12N9/22 | Oldest priority date: 2010-12-23 | Publication date: 2017-01-03

Score: 14.999643 | Text size: 192236 | Find: similardocuments

JohnsHopkins Clinical Compound Library ( ̃1100 compounds) and a 50,000 compoundcollection fromChemDiv. ... Screening will continue with the ChemDiv collection,as it contains a large number of synthetic compounds, and has the potential of

METHODS AND KITS FOR DETECTING PROTEIN-PROTEIN INTERACTIONS

CABANTOUS,Stéphanie [FR]; KORAÏCHI,Faten [FR];FAVRE, Gilles[FR]

Publicationdate: 2016-12-29 | Patent publication No.: WO-2016207313-A1|Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHEMÉDICALE) [FR]; UNIVERSITÉ PAUL SABATIER TOULOUSE III [FR] | IPC: G01N33/542;G01N33/68 | Oldestpriority date: 2015-06-24 | Publication date: 2016-12-29

Score: 13.556976 | Text size: 115481 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

USE OF NOVEL AUTOPHAGY INHIBITORS TO TREAT AUTOPHAGY RELATED HUMANDISEASES

Jianbo Yue [CN]; Yingying Lu [CN]

Score: 14.831028 | Text size: 50288 | Find: similardocuments

FIG. 14shows a virtual screening strategy for vacuolin-1 analogue identificationusing ChemDiv.

ONCOGENIC ROS1 AND ALK KINASE INHIBITOR

Xiao Jun Yao[CN];Lai Han Leung[CN];Lian Xiang Luo[CN];Liang Liu [CN]

Score: 14.039395 | Text size: 79359 | Find: similardocuments

G341-0312was purchased from ChemDiv company.

COMPOUNDS FOR TREATING PAIN SYNDROME AND OTHER DISORDERS

WU, JayJie-qiang [US]

Publicationdate: 2016-12-21 | Patent publication No.: EP-3106166-A1|Assignees: VM Therapeutics LLC [US] | IPC: A61K31/517; C07D403/08; C07D403/02; C07D495/04; A61P29/00; A61P25/06 | Oldest priority date: 2008-02-29 | Publication date: 2016-12-21

Score: 12.484504 | Text size: 106447 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (SanDiego, CA), ChemDiv (San Diego, CA), SPECS (Delft, TheNetherlands), Timtec (Newark, DE) or the compounds can be

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ANTIBACTERIAL COMPOUNDS

WILSON, FrancisXavier [GB];JOHNSON, PeterDavid [GB];VICKERS, Richard[GB];STORER, Richard[GB];WYNNE, GrahamMichael [GB]; ROACH, AlanGeoffrey [GB]; DE MOOR, Olivier[GB];DORGAN, ColinRichard [GB]; DAVIS, PaulJames [GB]

Score: 12.290053 | Text size: 133709 | Find: similardocuments

[M7-A7, Vol.26, No2, Jan 2006]. (ii) Commercial Compounds All compounds below werepurchased fromChemDiv:3,3'-(1H,1'H-5,5'-Bibenzo[d]imidazole-2,2'-diyl)dianiline (Compound 2).

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SWEET FLAVOR MODIFIER

CatherineTachdjian [US]; DonaldKaranewsky [US]; Sara Werner [US]; VincentDarmohusodo [US]; Jeff Yamamoto[US]

Score: 10.633806 | Text size: 241148 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

INDOLINYL-SULFONAMIDE INHIBITORS OF TANKYRASE AND METHODS OF USE THEREOF

LUM, Lawrence[US];CHEN, Chuo [US]; ZHANG, Xuewu[US];KULAK, Ozlem[US];WU, Xiaofeng[US]

Score: 16.882145 | Text size: 156200 | Find: similardocuments

Sources ofchemicals: IWR-3 to -8 (ChemDiv or ChemBridge), XAV-939 (Maybridge)and LGK-974 (ActiveBiochem). See Example 4 for IWR-8 synthesis. ... 1.65-1 .55(m, 2H), 1.05 (t, J=7.1 Hz, 3H). [[image:imgf000056_0001]] The procedurereported by ChemDiv (Dorogov, et at, 2004) was used tosynthesize the presumed structure of IWR8 (1) that was originally purchasedfrom ChemDiv (scheme).

COMPLEMENT C3D-BINDING COMPOUNDS

MORIKIS, Dimitrios[US];GORHAM, Jr.Ronald, D. [US]

Score: 13.793969 | Text size: 95555 | Find: similardocuments

Selecteddrug-like compounds were obtained from Enamine, Pharmeks, ChemDiv,ChemBridge, and Maybridge.

INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS

Sanjay A. Desai[US];Ajay D. Pillai[IN]

Publicationdate: 2016-11-10 | Patent publication No.: US-20160324866-A1|Assignees: The United States of America, as represented by the Secretary, Departmentof Health and Human Serv [US] | IPC: A61K31/553; A61K31/4355; A61K31/437; A61K31/4439; A61K31/433; A61K31/421 | Oldest priority date: 2008-07-23 | Publication date: 2016-11-10

Score: 14.293713 | Text size: 54941 | Find: similardocuments

methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, Calif. or Peakdale MolecularLimited, High Peak, England.

SMALL MOLECULE RAS LIGANDS

STOCKWELL, BrentR. [US];THOMAS, StevenB. [US]

Publicationdate: 2016-11-03 | Patent publication No.: WO-2016176338-A1|Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US] | IPC: A61K31/132;A61K35/02 | Oldestpriority date: 2015-04-30 | Publication date: 2016-11-03

Score: 13.327991 | Text size: 108558 | Find: similardocuments

availablecompounds were compiled from the inventories of Asinex, Enamine,Chembridge, ChemDiv, IBS, Life, Maybridge and TimTec.

HIGH-AFFINITY SMALL MOLECULE FORMYLPEPTIDE RECEPTOR LIGANDS FROMSCREENING OF COMBINATORIAL MIXTURE-BASED LIBRARIES

Bruce S. Edwards[US];Larry A. Sklar[US];ClemenciaPinilla [US]; Richard A.Houghten [US]; Jon R. Appel[US];Marc A.Giulianotti [US]; JoseMedina-Franco [US]

Publicationdate: 2016-11-03 | Patent publication No.: US-20160320402-A1|Assignees: STC.UNM [US]; TORREY PINES INSTITUTE FOR MOLECULAR STUDIES [US] | IPC: G01N33/68;A61K31/17; A61K31/496; C40B30/02; G01N33/74 | Oldest priority date: 2013-02-07 |Publicationdate: 2016-11-03

Score: 12.290053 | Text size: 190856 | Find: similardocuments

on the basisof a preliminary computational screen of 480,000 compounds from thecommercial ChemDivcollection using an FPR homology model andpharmacophore (Edwards, et al., 2005).

METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS

Jay Jie-Qiang Wu[US]

Score: 12.685205 | Text size: 98381 | Find: similar documents

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

COMPOUNDS FOR TREATING PRURITIC CONDITIONS

Amale HAWI [US]

Score: 13.327991 | Text size: 96590 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

COMPOUNDS FOR TREATING PRURITIC CONDITIONS

HAWI, Amale [US]

Score: 13.556976 | Text size: 88796 | Find: similar documents

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, PA, ChemDiv of San Diego, CA, Chembridge of SanDiego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the

SELECTIVE CALCIUM CHANNEL ANTAGONISTS

Dalton J.Surmeier, JR. [US]; Richard B.Silverman [US]; Soosung Kang[US];Garry Cooper[US]

Score: 13.556976 | Text size: 98507 | Find: similardocuments

to screen60,480 commercial compounds (ADSI set 6,800; ChemBridge diverse/lead like set20,000; ChemDivdiverse set 30,000; NIH clinical trial set 480,NCl/DTP set 3,200).

Sweet flavor modifier

Sara Adamski-Werner[US];VincentDarmohusodo [US]; CatherineTachdjian [US]; DonaldKaranewsky [US]; Goran Petrovic[US];Rachel Kimmich[US];Joseph Fotsing[US]

Publicationdate: 2016-10-25 | Patent publication No.: US-09475803-B2|Assignees: Senomyx, Inc. [US] | IPC: C07D417/14; C07D417/12; A23L1/226; A23L1/302; C07D471/04; C07D473/00;C07D498/04 | Oldestpriority date: 2013-02-19 | Publication date: 2016-10-25

Score: 11.569273 | Text size: 205848 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

INHIBITORS OF ESTROGEN RECEPTOR ALPHA AND THEIR USE AS THERAPEUTICS FORCANCER

TCHERKASSOV,Artem [CA];RENNIE, Paul, S.[CA];SINGH, Kriti[CA];MUNUGANTI, RaviShashi Nayana [CA]

Publicationdate: 2016-10-20 | Patent publication No.: WO-2016165007-A1|Assignees: THE UNIVERSITY OF BRITISH COLUMBIA [CA] | IPC:C07D411/06; A61K31/166; A61K31/357; A61K31/36; A61K31/381; A61K31/404;A61K31/4152; A61K31/4155; A61P35/00; C07D333/64; C07D409/06 | Oldest priority date: 2015-04-17 | Publication date: 2016-10-20

Score: 13.793969 | Text size: 107667 | Find: similardocuments

VPC-13002),ChemBridge (compounds VPC-16007, VPC-16003, VPC-16004, VPC-16222 and VPC-16223),ChemDiv (compound VPC-16019), TimTec (compounds VPC-16041 ,VPC-16046, VPC-16038, VPC-16040 and VPC-16021 )

COMPOSITIONS FOR TREATING AND/OR PREVENTING CELL OR TISSUE NECROSISSPECIFICALLY TARGETING CATHEPSIN C AND/OR CELA1 AND/OR CELA3A AND/ORSTRUCTURALLY RELATED ENZYMES THERETO

NATHAN, Ilana[IL];KHALFIN, Boris[IL];NATHAN, Ilana[IL];KHALFIN, Boris[IL]

Publicationdate: 2016-10-13 | Patent publication No.: WO-2016162870-A1|Assignees: NATHAN, Ilana [IL]; KHALFIN, Boris [IL] | IPC:A61K31/00; A61K31/415; A61K31/4178; A61K31/4196; A61K31/426; A61K31/4439;A61K31/454; A61K31/496; A61K31/4045; C07D401/04; C07D403/04; C07D407/14;C07D417/12; C07D417/14; C07K16/40; C12N15/113; A61P9/10; A61P25/28; A61P39/00;A61P43/00 | Oldestpriority date: 2015-04-07 | Publication date: 2016-10-13

Score: 15.551273 | Text size: 271484 | Find: similardocuments

All thecompounds disclosed in Table 1 hereinabove were purchased from ChemDiv,San Diego, CA. ... similarities and topological analogs [00437] The followingcompounds were prepared by vendor ChemDiv Inc.(San Diego, USA) andtheir respective ChemDiv I.D. numbers are shown in Table 4below.

SMALL MOLECULE INHIBITORS OF TLR2 SIGNALING

VOGEL, Stefanie,N. [US];MACKERELL,Alexander [US]

Publicationdate: 2016-10-13 | Patent publication No.: WO-2016164414-A1|Assignees: UNIVERSITY OF MARYLAND, BALTIMORE [US] | IPC:A01K67/00; A61K31/16; A61K31/19; A61K31/195 | Oldest priority date: 2015-04-06 | Publication date: 2016-10-13

Score: 20.166632 | Text size: 91203 | Find: similardocuments

structure:[[image:imgf000014_0001]] Formula IV Compound C25 is available commerciallyfrom ChemDiv(San Diego, CA) as compound chemdiv4166820. CompoundC26 refers to a compound having the following chemical structure:[[image:imgf000014_0002]] Formula V Compound C26 is available commercially fromChemDiv (SanDiego, CA) as compound chemdiv4166839. ... structure: [[image:imgf000016_0002]]Formula IX Compound C32 is available commercially from ChemDiv (SanDiego, CA) as compound chemdiv0322211. Compound C33 refers to a compound havingthe following chemical structure: [[image:imgf000017_0001]] Formula X CompoundC33 is available commercially from ChemDiv as compoundchemdiv0328055.

METHODS FOR TREATMENT OF RETINAL DISEASE BY PHOTORECEPTOR GENE EXPRESSIONMODULATION

REH, Thomas, A.[US];NAKAMURA, Paul[US];DING, Sheng [US]

Publicationdate: 2016-10-06 | Patent publication No.: WO-2016160718-A1|Assignees: UNIVERSITY OF WASHINGTON [US]; THE J. DAVID GLADSTONE INSTITUTES, ATESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J. DAVID GLADSTONE [US] | IPC: A61K31/519;C07D495/04; A61P27/02 | Oldestpriority date: 2015-03-27 | Publication date: 2016-10-06

Score: 18.319254 | Text size: 58972 | Find: similardocuments

is CA8801 :[[image:imgf000009_0002]] Compounds CA88 and CA8801 are commercially availablefromChemDiv (San Diego, CA). ... is CA9513 :[[image:imgf000010_0003]] Compounds CA95 and CA9513 are commercially availablefrom ChemDiv (San Diego, CA). ... Nr2e3 interacting moleculesspecifically identified herein were obtained commercially from ChemDiv (SanDiego, CA).

Pharmacological Chaperones for Treating Obesity

Jian-Qiang Fan[US];KennethValenzano [US]; Gary Lee [US]; Michel Bouvier[CA];PatriciaRené [CA]

Publicationdate: 2016-10-06 | Patent publication No.: US-20160287581-A1|Assignees: Amicus Therapeutics, Inc . [US]; Universite de Montreal [CA] | IPC: A61K31/495;A61K9/00 | Oldestpriority date: 2005-06-03 | Publication date: 2016-10-06

Score: 17.126425 | Text size: 132642 | Find: similardocuments

ResearchBiochemicals; Cetek Corporation; Charybdis Technologies, Inc.; ChemBridgeCorporation; ChemDiv, Inc.; ChemGenics Pharmaceuticals Inc.;ChemOvation Ltd.; ChemStar, Ltd.; Chrysalon; ComGenex, Inc. ... compounds);Maybridge 2 (704 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352compounds);ChemDiv Combilab and International (28,864 compounds);Mixed Commercial Plate 1 (352 compounds); Mixed ... ActiMol; Aral Biosynthetics;ASDI Biosciences; Biotechnology Corporation of America; Chembridge;ChemDiv;Florida Center—Heterocyclic Compounds; Microsource/MSDI; NorthStar; Peakdale;Texas Retaining

SWEET FLAVOR MODIFIER

TACHDJIAN,Catherine [US]; TANG, Xiao Qing[US];KARANEWSKY,Donald S. [US]; SERVANT, Guy[US];LI, Xiaodong[US];ZHANG, Feng [US]; CHEN, Qing [US]; ZHANG, Hong [US]; DAVIS, Timothy[US];DARMOHUSODO,Vincent [US]; WONG, Melissa[US];SELCHAU, Victor[US]

Publicationdate: 2016-10-05 | Patent publication No.: EP-2742026-B1|Assignees: Senomyx, Inc. [US] | IPC: A23L27/00; A23L2/60; C07D215/42; C07D215/54; C07D401/12; C07D405/12;C07D451/06 | Oldest prioritydate: 2011-08-12 | Publication date: 2016-10-05

Score: 10.928354 | Text size: 213341 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, PA, ChemDiv of San Diego, CA, Chembridge of SanDiego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the

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Methods for producing enteroendocrine cells that make and secrete insulin

Chutima Talchai[US];Domenico Accili[US]

Publicationdate: 2016-10-04 | Patent publication No.: US-09457079-B2|Assignees: The Trustees Of Columbia University In The City Of New York [US] | IPC: A61K39/395;A61K31/7088; C12N15/113; G01N33/50 | Oldestpriority date: 2010-05-12 | Publication date: 2016-10-04

Score: 11.239684 | Text size: 193357 | Find: similardocuments

Electrophysiological assays using oocytes that express human enac and theuse of phenamil to improve the effect of enac enhancers in assays usingmembrane potential reporting dyes

Guy Servant [US]; Hong Chang [US]; Cyril Redcrow[US];Sumita Ray [US]; Imran Clark [US]; Bryan Moyer [US]

Score: 12.484504 | Text size: 153497 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

CELLS EXPRESSING APOLIPOPROTEIN EAND USES THEREOF

Susan L.Lindquist [US]; Priyanka Narayan[US]

Publicationdate: 2016-09-01 | Patent publication No.: US-20160251665-A1|Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C12N15/81;C07K14/775; C07K14/47; G01N33/92 | Oldestpriority date: 2014-09-12 | Publication date: 2016-09-01

Score: 7.572373 | Text size: 412859 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

4-AMINOQUINAZOLINE DERIVATIVES AS MTH1 INHIBITORS FOR THE THERAPY OFCANCER

HUBER, Kilian[AT]

Score: 14.719831 | Text size: 179310 | Find: similardocuments

Certaincompounds of formula (I) are also commercially available, e.g., from ChemDiv (SanDiego, CA, USA). ... by UV (A280). 4-Aminoquinazoline compounds The followingcompounds (1 ) to (3) were obtained fromChemDiv (San Diego, CA,USA) and were tested for their activity on MTH1 as described further

INHIBITORS OF FAPP2 AND USES THEREOF

Raffaele LAMONTAGNA [IT]; Maria AntoniettaDE MATTEIS [IT]; GiovanniD'ANGELO [IT]

Publicationdate: 2016-09-01 | Patent publication No.: US-20160250221-A1|Assignees: FONDAZIONE TELETHON [IT] | IPC: A61K31/5415; A61K31/192; C12Q1/68; A61K31/4045; A61K31/4453; A61K31/454;A61K31/343; A61K31/41 | Oldestpriority date: 2013-07-25 | Publication date: 2016-09-01

Score: 11.918776 | Text size: 196602 | Find: similardocuments

vendors suchas ChemBridge Libraries (www.chembridge.com), BIOMOL International,ASINEX, ChemDiv, ChemDB, ICCB-Longwood.

Selective calcium channel antagonists

Dalton J.Surmeier, Jr. [US]; Richard B.Silverman [US]; Soosung Kang[US];Garry Cooper[US]

Score: 13.556976 | Text size: 114132 | Find: similardocuments

to screen60,480 commercial compounds (ADSI set 6,800; ChemBridge diverse/lead like set20,000; ChemDivdiverse set 30,000; NIH clinical trial set 480,NCl/DTP set 3,200).

Plant genes that confer resistance to trichothecene mycotoxins andfusarium head blight

Nilgun ErekenTumer [US];John EdwardMcLaughlin [US]; Mohamed AnwarBin-Umer [US]

Score: 13.10661 | Text size: 136412 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS ANDMETHODS OF TREATMENT

Richard SmithLarson [US];Larry A. Sklar[US];Bruce S. Edwards[US];Juan JacobStrouse [US]; Irenalvnitski-Steele [US]; Hadya M. Khawaja[US];Jerec WarrenRicci [US];Jeffrey Aube[US];JenniferElizabeth Golden [US]; TuanIi Yao [US]; Warren S. Weiner[US];Chad E.Schroeder [US]

Score: 14.999643 | Text size: 206714 | Find: similardocuments

Compoundsordered for SAR by commerce were purchased from ChemDiv (SanDiego, Calif.) and Ryan Scientific (Mt. ... Compounds ordered for SAR bycommerce were purchased from ChemDiv (San Diego, Calif.) andRyan Scientific (Mt.

Sweet flavor modifier

CatherineTachdjian [US]; DonaldKaranewsky [US]; Sara Werner [US]; VincentDarmohusodo [US]; Jeff Yamamoto[US]

Publicationdate: 2016-08-23 | Patent publication No.: US-09420814-B2|Assignees: Senomyx, Inc. [US] | IPC: C07D471/04; C07D417/12; C07D417/14; A23L1/236; A23L1/22; A23L2/56;A23L2/60; A23L1/09 | Oldestpriority date: 2012-08-06 | Publication date: 2016-08-23

Score: 10.633806 | Text size: 268180 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

Vitamin D receptor-coregulator inhibitors

Alexander E.Arnold [US];Preetpal SinghSidhu [US];PremchendarNandhikonda [US]; Rakesh K. Singh[US]

Publicationdate: 2016-08-16 | Patent publication No.: US-09416104-B2|Assignees: UWM Research Foundation, Inc. [US]; Women and Infants' Hospital of RhodeIsland [US] | IPC: C07D407/12; C07D209/16; C07D209/10; C07D209/14; A61K45/06; A61K31/404;C07D401/12 |Oldest priority date: 2011-08-26 | Publicationdate: 2016-08-16

Score: 11.239684 | Text size: 193603 | Find: similardocuments

The smallmolecule collection consisted of 275,000 unique compounds from commercial sources(ChemDiv, ChemBridge, and Life Chemicals).

MULTIVALENT RAS BINDING COMPOUNDS

Brent R.Stockwell [US]; Matthew Welsch[US]

Publicationdate: 2016-08-11 | Patent publication No.: US-20160229836-A1|Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US] | IPC: C07D401/12;C07D209/14; C07D403/12 | Oldestpriority date: 2014-05-30 | Publication date: 2016-08-11

Score: 10.633806 | Text size: 232265 | Find: similardocuments

availablecompounds were compiled from the inventories of Asinex, Enamine,Chembridge, ChemDiv, IBS, Life, Maybridge and TimTec.

Small-molecule inhibitors of dengue virus proteases

Stanley J.Watowich [US]; Usha Viswanathan[US]

Score: 14.692947 | Text size: 60516 | Find: similardocuments

compoundsthat were available for purchase from either ChemBridge Corporation (San Diego,Calif.), ChemDiv Inc. (San Diego, Calif.), Ryan ScientificInc.

Compounds, compositions, and methods for reducing or eliminating bittertaste

Kambiz Shekdar[US];Daniel Lavery[US];Joseph Gunnet[US];Jessica Langer[US];Jane V. Leland[US];David Hayashi[US];Peter H. Brown[US];Louise Slade[US];William P. Jones[US]

Publicationdate: 2016-08-09 | Patent publication No.: US-09408407-B2|Assignees: CHROMOCELL CORPORATION [US]; KRAFT FOODS GROUP BRANDS LLC [US] | IPC: A61K47/00; A23L1/22;A61K47/06; A61K47/08; A61K47/10; A61K47/12; A61K47/14; A61K47/22; A61K47/44;A23L1/226; C07C63/06; C07C69/78; C07D311/20; C07D311/22; C07D311/72 | Oldest priority date: 2010-04-15 | Publication date: 2016-08-09

Score: 8.202065 | Text size: 418887 | Find: similardocuments

wereobtained from commercial vendors for synthetic and natural compounds, includingVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

Screening methods for identifying Plasmodium proteases inhibitors

Jean-ChristopheBarale [FR];Anthony Bouillon[FR];David Giganti[FR];Olivier LouisGabiel Gorgette [FR]; Veronique Stoven[FR];Michael Nilges[FR];Odile Puijalon[FR]

Score: 14.039395 | Text size: 82701 | Find: similardocuments

Database Thevirtual screening was performed using the commercially available compoundsfrom Chemdiv, Inc (chemdiv.com). The Chemdiv molecules werefiltered using the program Filter (openeye.

Method for treating pain syndrome and other disorders

Jay Jie-Qiang Wu[US]

Publicationdate: 2016-08-02 | Patent publication No.: US-09402848-B2|Assignees: VM Therapeutics LLC [US] | IPC: A61K31/519; A61K31/4184; A61K31/498; C07D401/06; C07D471/04; C07D513/04 | Oldest priority date: 2008-02-29 | Publication date: 2016-08-02

Score: 12.892465 | Text size: 103077 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)

Alan F. List[US];Sheng Wei [US]

Publicationdate: 2016-07-28 | Patent publication No.: US-20160215038-A1|Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: C07K14/705;A61K47/48; G01N33/68 | Oldestpriority date: 2013-07-05 | Publication date: 2016-07-28

Score: 11.569273 | Text size: 162870 | Find: similardocuments

Corporation(16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA, www.chembridge.com); ChemDiv (6605Nancy Ridge Drive, San Diego, Calif.

Compositions Associated with and Methods of Managing Neutrophil Movement

Richard H. Gomer[US];Nehemiah Cox[US]

Publicationdate: 2016-07-21 | Patent publication No.: US-20160208002-A1|Assignees: Richard H. Gomer [US]; Nehemiah Cox [US] | IPC:C07K16/28; A61K31/7056; A61K31/192; A61K31/7034; A61K31/427; A61K31/63 | Oldest priority date: 2013-09-30 | Publication date: 2016-07-21

Score: 13.793969 | Text size: 72569 | Find: similardocuments

Compound 1(ChemBridge, San Diego, Calif.), and compound 3 (ChemDiv, San Diego,Calif.

Anti-depression Compounds

Steven L.McKnight [US]; Andew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]; Jeffrey M.Zigman [US]

Publicationdate: 2016-07-21 | Patent publication No.: US-20160206596-A1|Assignees: Board of Regents of The University of Texas System [US] | IPC: A61K31/4045;A61K31/404; A61K31/422; A61K31/4188; A61K31/506; A61K31/4192; A61K31/4155;A61K31/4439; A61K31/437 | Oldestpriority date: 2009-01-09 | Publication date: 2016-07-21

Score: 17.703602 | Text size: 739198 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00139]] This compound can be purchased from ChemDiv, Inc.Example61 1-(3,6-dibromo-9H-carbazol-9-yl)-3(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00140]] This compound can be purchased from ChemDiv, Inc. Example62 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00141]] This compound can be purchased from ChemDiv, Inc. Example63 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00142]] This compound can be purchased from ChemDiv, Inc. Example

Pro-Neurogenic Compounds

Steven L.McKnight [US]; Joseph M. Ready[US];Andrew A. Pieper[US];Jef K. DeBrabander [US]

Publicationdate: 2016-07-21 | Patent publication No.: US-20160206594-A1|Assignees: Board of Regents of The University of Texas System [US] | IPC: A61K31/403;A61K31/422; A61K31/4155; A61K31/506; A61K31/4192; A61K31/404; A61K31/4439;A61K31/437 | Oldestpriority date: 2009-01-09 | Publication date: 2016-07-21

Score: 19.449032 | Text size: 284965 | Find: similardocuments

from ChemDiv,Inc. Example 591-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol [[image:EMI-C00109]]Purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00110]] Purchased from ChemDiv, Inc. Example 611-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol [[image:EMI-C00111]]Purchased fromChemDiv, Inc. Example 621-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00112]] Purchased from ChemDiv, Inc. Example 631-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol [[image:EMI-C00113]]Purchased from ChemDiv, Inc. Example

Methods and Compositions for Re-activating Epstein-Barr Virus andScreening Compounds Therefor

Paul M.Lieberman [US]; NadezhdaTikmyanova [US]; Joseph M.Salvino [US]

Publicationdate: 2016-07-21 | Patent publication No.: US-20160206601-A1|Assignees: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY [US]; DREXEL UNIVERSITY [US] | IPC: A61K31/437;C12Q1/02; A61K31/69; A61K31/522; A61K45/06; A61K31/19 | Oldest priority date:2013-08-31 | Publication date: 2016-07-21

Score: 18.946571 | Text size: 103077 | Find: similardocuments

FIG. 2B is ascatter plot of luminescence values for HTS campaign of the ChemDiv library.The well number is indicated on the X-axis. FIG. 2C is a scatter plot of datafrom HTS of ChemDiv screen (FIG. 2B) re-sorted according tothe fold induction of luminescence relative to DMSO. FIG. ... clinicalcollection, a 14,400 compound library from Maybridge, and a 50,000 compound libraryfrom ChemDiv. The Maybridge “Hit Finder” library representslead-like diversity from the larger Maybridge screening collection (56,000).The ChemDivlibrary consists of a 30,000 compound “DiscoveryChemistry” set of diverse lead-like small

Inhibitors of the plasmodial surface anion channel as antimalarials

Sanjay A. Desai[US];Ajay D. Pillai[IN]

Publicationdate: 2016-07-19 | Patent publication No.: US-09394316-B2|Assignees: The United States of America, as represented by the Secretary, Departmentof Health and Human Services [US] | IPC: A61K31/41; A61K31/44; C07D513/04; A61K31/165; A61K31/4155; A61K31/423;A61K31/4245; A61K31/433; A61K31/4355; A61K31/437; A61K31/4439; A61K31/4741;A61K31/4745; A61K31/50; A61K31/554; A61K45/06; C07D263/57; C07D281/16;C07D413/14; C07D417/06; C07D491/048; C07D403/08; C07D498/04 | Oldest priority date: 2008-07-23 |Publicationdate: 2016-07-19

Score: 14.557414 | Text size: 51201 | Find: similardocuments

methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, Calif. or Peakdale MolecularLimited, High Peak, England.

A high-throughput assay to identify molecules that modulate Rb-E2Fbinding

Seth M Rubin[US]

Score: 15.875378 | Text size: 19494 | Find: similardocuments

PreliminaryScreen Results The investigators tested ̃21,000 compounds from the ChemDiv libraryin the UCSC Chemical Screening Center at a concentration of 50 μM.

Sweet flavor modifier

SaraAdamski-Werner [US]; VincentDarmohusodo [US]; CatherineTachdjian [US]; DonaldKaranewsky [US]

Publicationdate: 2016-06-21 | Patent publication No.: US-09371317-B2|Assignees: Senomyx, Inc. [US] | IPC: C07D417/14; C07D417/12; A23L1/226; A23L1/302; C07D471/04; C07D473/00;C07D498/04 | Oldestpriority date: 2013-02-19 | Publication date: 2016-06-21

Score: 12.484504 | Text size: 148288 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

Identification of compounds that disperse TDP-43 inclusions

Benjamin Wolozin[US];Marcie Glicksman[US];Gregory D. Cuny[US];Justin Boyd [US]

Publicationdate: 2016-06-07 | Patent publication No.: US-09359363-B2|Assignees: AQUINNAH PHARMACEUTICALS, INC. [US]; THE BRIGHAM AND WOMEN'S HOSPITAL, INC.[US] |IPC: C07D487/04; C07D207/36; C07D211/26; C07D211/52; C07D215/227; C07D215/36;C07D239/52; C07D239/94; C07D401/04; C07D401/12; C07D403/06; C07D417/04;A61P25/28; A61K31/4025; A61K31/445; A61K31/454; A61K31/4545; A61K31/47;A61K31/505; A61K31/517; A61K31/519; A61K31/551; A61K31/365; A61K31/704;C07D211/34; G01N33/50 | Oldestpriority date: 2011-05-20 | Publication date: 2016-06-07

Score: 15.290299 | Text size: 175674 | Find: similardocuments

Exemplaryembodiments of compounds of formulas (I)-(VI) may be obtained commerciallyfrom ChemDiv (San Diego, Calif.; http://us.chemdiv.com), ChemBridge(San Diego, Calif.; http://www.chembridge. ... C279-0807) are availablefrom ChemDiv.

TARGETING HUMAN THYMIDYLATE KINASE INDUCES DNA REPAIR TOXICITY INMALIGNANT TUMOR CELLS

Zee-Fen CHANG[TW];Jim-Min FANG[TW]

Publicationdate: 2016-06-02 | Patent publication No.: US-20160151362-A1|Assignees: NATIONAL YANG-MING UNIVERSITY [TW]; NATIONAL TAIWAN UNIVERSITY [TW] | IPC: A61K31/496;A61K31/704; C07D417/04; C07D275/04; C07F7/18; A61K31/695; C07D513/04;C07D519/00 | Oldestpriority date: 2010-11-29 | Publication date: 2016-06-02

Score: 11.239684 | Text size: 197565 | Find: similardocuments

2010) wasmodified and used to screen 21,120 structurally diversified compounds selectedfrom ChemDivlibrary (San Diego, USA).

Anti-cancer compounds targeting Ral GTPases and methods of using the same

Dan Theodorescu[US];MichaelFitzpatrick Wempe [US]; David Ross [US]; Samy Meroueh[US];Martin A.Schwartz [US]; Phillip Reigan[US]

Publicationdate: 2016-05-31 | Patent publication No.: US-09353121-B2|Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate [US]; THEUNIVERSITY OF VIRGINIA PATENT FOUNDATION [US]; INDIANA UNIVERSITY RESEARCH ANDTECHNOLOGY CORPORATION [US] | IPC: A61K31/4162; A61K31/351; A61K31/437; A61K31/505; A61K31/5513; A61K45/06;C07D491/052 | Oldestpriority date: 2011-12-21 | Publication date: 2016-05-31

Score: 12.484504 | Text size: 146384 | Find: similardocuments

To do so,RalA-GDP was set up for docking, and the ChemDiv library(v2006.

Defensin-like molecules as novel antimicrobial agents

Erik De Leeuw[US];Alexander D.Mackerell, Jr. [US]

Publicationdate: 2016-05-31 | Patent publication No.: US-09351963-B2|Assignees: University of Maryland, Baltimore [US] | IPC:A61K31/35; A61K31/351; A61K31/40; A61K31/403; A61K31/428; A61K31/404;A61K31/4174; A61K31/09; A61K31/05; A61K31/4709; A61K31/433 | Oldest priority date: 2010-11-04 | Publication date: 2016-05-31

Score: 14.165414 | Text size: 84337 | Find: similardocuments

Maybridge(Thermo Fisher Scientific Inc., Wattham, Mass.), ChemBridge (San Diego,Calif.), and ChemDiv (San Diego, Calif.), which contain 59676,482276, and 533143 compounds, respectively.

OSTEOCALCIN AS A TREATMENT FOR FRAILTY ASSOCIATED WITH AGING

KARSENTY, Gerard[US];MERA, Paula [US]; ARTEAGA-SOLIS,Emilio [US]

Score: 9.838301 | Text size: 320714 | Find: similardocuments

MaybridgeHitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds);ChemDiv Combilaband International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds);Mixed

COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATEACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14

Nhan Tran [US]; Nathalie Meunice[US];Harshil Dhruv[US];Hongwei Yin [US]

Publicationdate: 2016-05-26 | Patent publication No.: US-20160146784-A1|Assignees: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE [US] | IPC: G01N33/50;A61K31/53; A61K31/47; A61K31/635; A61K31/542; A61K31/433; A61K31/498;A61K31/437; A61K31/4045; A61K31/4155; A61K31/5513; A61K31/426; A61K31/55;A61K31/519; A61K31/422; A61K31/4192; A61K31/541; A61K31/167 | Oldest priority date: 2013-07-09 | Publication date: 2016-05-26

Score: 18.078405 | Text size: 196891 | Find: similardocuments

implementedto identify virtual hits from a vendor compound library of peptidomimeticmolecules (ChemDiv, 13,637 compounds). ... The peptidomimetic setof ChemDiv (version of May 2011; 13,137 compounds) wasprepared using LigPrep version 2.5 in Schrodinger v2011 ... The peptidomimeticset of ChemDiv (13,137 compounds, v05.2011) was selected forthis study and pre-processed as described in methods. ... As shown in FIG. 10A,4 compounds from the supplier ChemDiv with compoundidentifiers G873-0032, F151-0435, D715-0890, and J004-1091 showed an average... These core substructures served as query to perform a substructure searchin the ChemDiv online catalogue.

MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USESTHEREOF

TURCHI, John J.[US]

Publicationdate: 2016-05-19 | Patent publication No.: WO-2016077752-A2|Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] | IPC: C07D401/04;C07D403/04; C07D231/06; A61K31/4725; A61K31/4155; A61P35/00 | Oldest priority date: 2014-11-13 | Publication date: 2016-05-19

Score: 13.793969 | Text size: 86304 | Find: similardocuments

Chemicalcompounds, either purchased from ChemDiv or synthesized in thelaboratory, were suspended in DMSO and titrated as detailed in each figure.

METHODS FOR MATURING CARDIOMYOCYTES AND USES THEREOF

HanneleRUOHOLA-BAKER [US]; KavithaKUPPUSAMY [US]; Henrik SPERBER[US]

Score: 11.918776 | Text size: 190003 | Find: similardocuments

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive ChemistryLtd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.

INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS

DESAI, Sanjay,A. [US];PILLAI, Ajay, D.[US]

Publicationdate: 2016-05-11 | Patent publication No.: EP-2313100-B1|Assignees: The United States Of America, As Represented By The Secretary, DepartmentOf Health And Human Services [US] | IPC: A61K31/554; A61K31/165; A61K31/4245; A61K31/433; A61K31/4355; A61K31/437;A61P33/06; A61K31/4155; A61K31/423; A61K31/4439; A61K31/4745; A61K31/50;A61K31/4741; C07D413/14; C07D403/08; C07D417/06; C07D263/57; C07D491/048;C07D498/04; C07D281/16; C07D513/04 | Oldestpriority date: 2008-07-23 | Publication date:2016-05-11

Score: 14.692947 | Text size: 58909 | Find: similardocuments

methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, CA or Peakdale Molecular Limited,High Peak, England.

External link

SELECTIVE INHIBITORS OF CONSTITUTIVE ANDROSTANE RECEPTOR

CHEN, Taosheng[US];CHERIAN, Milu[US];LIN, Wenwei [US]

Score: 11.175703 | Text size: 505967 | Find: similardocuments

Allylisothiocyanate and chemicals 81, 82, 84, 87, and 89 were purchased from ChemDiv (SanDiego, CA). Chemicals 1, 80, 83, 85, and 86 were purchased from ChemBridge (SanDiego, CA). ... the structure given by the formula: [[image:imgf000178_0001]] .[00533] CINPA1 was obtained from ChemDiv (San Diego, CA).

HIGHLY POTENT INHIBITORS OF PORCUPINE

Lawrence LUM[US];Chuo CHEN [US]

Publicationdate: 2016-04-28 | Patent publication No.: US-20160115177-A1|Assignees: The Board of Regents of the University of Texas System [US] | IPC: C07D495/04;A61K45/06; A61N5/10; A61K31/519 | Oldestpriority date: 2013-05-14 | Publication date: 2016-04-28

Score: 13.10661 | Text size: 112955 | Find: similardocuments

four IWPlead compounds (1-4) were identified in the initial screen of 200,000 compounds(ChemDiv, ChemBridge, ComGenex, Prestwick and TimTek libraries) bearsimilar molecular skeletons (FIG. 1).

SirT INHIBITORS THAT BIND TO NAD

Andrew D. Napper[US];Peter DiStefano[US];Rory Curtis [US]; Jeffrey Hixon[US];Thomas E.McDonagh [US]; L. Julie Huber[US];Jonathan M.Solomon [US]; Russel J. Thomas[GB];Jean-francoisPons [GB]

Score: 11.569273 | Text size: 177148 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, SanDiego, Calif.

METHODS AND COMPOSITIONS TO TREAT CANCER

Jeffrey Whitsett[US];Yutaka Maeda[US]

Score: 14.039395 | Text size: 62307 | Find: similardocuments

3-[2-(4-fluorobenzyl)imidazo[2,1-beta][1,3]thiazol-6-yl]-2H-chromen-2-one (iMDK) purchased from ChemDiv(San Diego,Calif.) was dissolved in DMSO.

Compositions and methods for inhibiting norovirus infection

Xi Jiang [US]; Ming Tan [US]; Xufu Zhang [CN]

Publicationdate: 2016-04-26 | Patent publication No.: US-09321803-B2|Assignees: Children's Hospital Medical Center [US] | IPC:A61K31/56; C07J41/00; C07J7/00; C07J9/00; C07J3/00 | Oldest priority date: 2013-07-12 | Publication date: 2016-04-26

Score: 14.039395 | Text size: 113020 | Find: similardocuments

Molport(http://www.molport.com) supplied by Maybridg, TimTec, ChemBridge, Pharmeks,Specs, Otava,ChemDiv, InterBioScreen Ltd, Vitas-M Laboratory, PrincetonBiomolecular Research and Enamine Ltd.

Plasmodial surface anion channel inhibitors for the treatment orprevention of malaria

Sanjay A. Desai[US]

Publicationdate: 2016-04-26 | Patent publication No.: US-09320786-B2|Assignees: The United States of America, as represented by the Secretary, Departmentof Health and Human Services [US] | IPC: A61K39/015; C07D413/14; C07D409/04; C07D409/14; C07D239/84; C07D417/06;C07D241/44; C07D263/57; C07D491/048; C07D498/04; C07D277/54; C07D513/04;C07D281/16; A61K31/42; A61K31/433; A61K31/495; A61K31/498; A61K31/50;A61K31/519; A61K31/554; C07K14/445; A61K31/422; A61K31/4741; A61K31/501;A61K31/517; C07K16/20; A61K45/06 | Oldestpriority date: 2011-04-12 | Publication date: 2016-04-26

Score: 15.906768 | Text size: 140738 | Find: similardocuments

Regulators of aldehyde dehydrogenase ALDH3A1 and related therapeuticmethods

Thomas D. Hurley[US]

Publicationdate: 2016-04-26 | Patent publication No.: US-09320722-B2|Assignees: Indiana University Research and Technology Corporation [US] | IPC: A61K38/00;A61P35/00; A61K31/145; A61K45/06; A61K31/167; A61K31/63; A61K31/635;A61K31/4184; A61K31/136; A61K31/381; A61K31/426; A61K31/4436; A61K31/4439;A61K31/4468; A61K31/5377; A61K31/5386; A61K31/553 | Oldest priority date: 2013-09-27 | Publication date: 2016-04-26

Score: 15.5924425 | Text size: 157389 | Find: similardocuments

The chemicallibraries for performing high throughput screening were purchased from ChemDiv Corp.and ChemBridge Corp. Mafosfamide was bought from Niomech-IIT GmbH, Bielefeld,Germany. ... selective inhibitors 2 8 Selective inhibitors 2 TABLE 4: ScreeningHit Compounds: (A) Hits from ChemDiv Screen: IC50 (micromolar)ALDH1A1IC50 (micromolar) ALDH2IC50 (micromolar) ALDH3A1 CD4

Methods for identifying inhibitors of solute transporters

Alan S. Verkman[US];Marc HarrisLevin [US]

Publicationdate: 2016-04-19 | Patent publication No.: US-09316633-B2|Assignees: The Regents of the University of California [US] | IPC:G01N33/50; G01N33/62; G01N33/68; G01N33/80 | Oldest priority date: 2006-11-16 | Publication date: 2016-04-19

Score: 14.450268 | Text size: 193749 | Find: similardocuments

drug-likecompounds (>90% with molecular size of 250-500 Da) obtained from acommercial source (CHEMDIV Inc., San Diego, Calif. ... Studies of UT-BInhibitors The activity of approximately 700 commercially available analogs (CHEMDIVInc. and Asinex; Moscow, Russia) of active compounds from the fourdistinct chemical structural classes

Small molecule inhibitors of influenza A RNA-dependent RNA polymerase

Kayvan Niazi[US];ShahroozRabizadeh [US]; Anne-Laure Le Ny[US];Oleksandr Buzko[US];Justin Golovato[US];PatrickSoon-Shiong [US]

Publicationdate: 2016-04-19 | Patent publication No.: US-09315464-B1|Assignees: Nant Holdings IP, LLC [US] | IPC: C07D215/52; C07D401/12; C07D401/04; C07D405/14; C07D413/12; C07D413/14;C07D401/14; G06F19/12; C07D498/04; C07D417/12; C07D417/14 | Oldest priority date: 2013-01-31 | Publication date: 2016-04-19

Score: 14.692947 | Text size: 60730 | Find: similardocuments

sulfamoylphenyl)-3-(thiophen-2-yl)-1H-pyrazole-4-carboxamide [[image:EMI-C00022]] A1008: (ChemDiv, E456-2276)2-(3- methoxyphenyl)-1-oxo-N-(4- sulfamoylphenyl)-1,2-dihydroisoquinoline-4-

Antibacterial compounds

Score: 12.484504 | Text size: 134284 | Find: similardocuments

Vol. 26, No2, January 2006]. (ii) Commercial Compounds All compounds below were purchasedfromChemDiv:3,3′-(1H,1′H-5,5′-Bibenzo[d]imidazole-2,2′-diyl)dianiline(Compound 2).

Antimicrobial Potentiators

Timothy J.Opperman [US]; Son T. Nguyen[US];Steven M. Kwasny[US];Xiaoyuan Ding[US]

Publicationdate: 2016-03-17 | Patent publication No.: US-20160075714-A1|Assignees: MICROBIOTIX, INC. [US] | IPC: C07D491/052; A61K31/5377; A01N43/90; A61K31/436; A61K31/5383; A61K31/551; A61K31/541;A61K31/553; A01N47/44; A61K45/06; A61K31/496 | Oldest priority date: 2013-05-03 | Publication date: 2016-03-17

Score: 11.569273 | Text size: 170320 | Find: similardocuments

librariesused in high-throughput screens were purchased from Chembridge (San Diego,Calif.), ChemDiv (San Diego, Calif.), and TimTec (Newark,Del.). MBX2319 was synthesized by Microbiotix, Inc.

PRO-NEUROGENIC COMPOUNDS

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Publicationdate: 2016-03-17 | Patent publication No.: US-20160074361-A1|Assignees: Board of Regents of the University of Texas System [US] | IPC: A61K31/403;A61K31/422; A61K31/4188; A61K31/404; A61K31/4192; A61K31/4155; A61K31/4439;A61K31/506 | Oldestpriority date: 2009-01-09 | Publication date: 2016-03-17

Score: 18.456491 | Text size: 511588 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 60 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00132]] This compound can be purchased from ChemDiv, Inc.Example61 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00133]] This compound can be purchased from ChemDiv, Inc. Example62 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00134]] This compound can be purchased from ChemDiv, Inc. Example63 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol [[image:EMI-C00135]]This compound can be purchased from ChemDiv, Inc. Example

Antimicrobial Compounds

Terence Moy [US]; Annie Conery[US];Kim Lewis [US]; Frederick M.Ausubel [US]; ReadPukkila-Worley [US]

Score: 18.04004 | Text size: 80724 | Find: similardocuments

BiologyProgram, Broad Institute, Cambridge, Mass.), ChemBridge kinases (San Diego,Calif.), ChemDiv (San Diego, Calif.), TimTec (Newark, Del. ...Synthesis (DOS) 11,666 1 0.01% ChemBridge kinases Commercial compounds: 8,24021 0.27% ChemDiv 11,616 12 0.10% TimTec 8,512 7 0.08%MayBridge 5,448 3 0.06% ChemBridge 704 1 0.14% Total 53,946b ... Example 6Antimicrobial Assay Methods Compounds 6, 7, 15 were purchased from TimTec and ChemDiv,dissolved in DMSO at a concentration of 5 or 10 mg/ml, and further diluted inDMSO as indicated.

Electrophysiological assays using oocytes that express human enac and theuse of phenamil to improve the effect of enac enhancers in assays usingmembrane potential reporting dyes

Guy Servant [US]; Hong Chang [US]; Cyril Redcrow[US];Sumita Ray [US]; Imran Clark [US]; Bryan Moyer [US]

Score: 12.290053 | Text size: 168305 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

Compounds for inhibiting mammalian s-nitrosoglutathione reductase

Sanghani, Paresh[US]

Publication date: 2016-03-09 | Patentpublication No.: EP-2581451-B1|Assignees: Indiana University Research and Technology Corporation [US] | IPC: C12Q1/25;A61P11/06; A61P11/00; A61P9/00; A61P15/00; A61P17/00; A61P25/28; A61K31/519;A61P29/00; A61P13/00; A61P35/00 | Oldestpriority date: 2008-01-17 | Publication date: 2016-03-09

Score: 13.793969 | Text size: 81798 | Find: similardocuments

Thescreening for GSNOR inhibitors was performed using a library of 60,000compounds from ChemDiv Inc in the Chemical Genomics Corefacility at Indiana University.

External link

Compositions and methods useful for the treatment and diagnosis ofinflammatory bowel disease

Joshua R.Friedman [US]; Adam Zahm [US]; Meena Thayu [US]; Nicholas Hand[US];Edwin deZoeten[US]

Score: 13.793969 | Text size: 98534 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Targeting human thymidylate kinase induces DNA repair toxicity inmalignant tumor cells

Zee Fen Chang[TW];Jim-Min Fang[TW];Chun-Mei Hu [TW]; Ming-Tyng Yeh[TW]

Publicationdate: 2016-03-08 | Patent publication No.: US-09278982-B2|Assignees: NATIONAL YANG-MING UNIVERSITY [TW]; NATIONAL TAIWAN UNIVERSITY [TW] | IPC: C07D513/04;C07D275/04; C07D275/06; A61K31/403; A61K31/425; A61K31/704; A61K45/06 | Oldest priority date: 2010-11-29 | Publication date: 2016-03-08

Score: 11.239684 | Text size: 190288 | Find: similardocuments

2010) was modifiedand used to screen 21,120 structurally diversified compounds selectedfrom ChemDivlibrary (San Deigo, USA).

Pro-neurogenic compounds

Steven L.McKnight [US]; Joseph M. Ready[US];Andrew A. Pieper[US];Jef K. DeBrabander [US]

Publicationdate: 2016-03-08 | Patent publication No.: US-09278923-B2|Assignees: Board of Regents of The University of Texas System [US] | IPC: A61K31/403;C07D209/08; A61K31/00; A61K31/415; A61K31/437; A61K31/44; A61K31/506;C07D209/86; C07D401/06; C07D403/06; C07D403/12; C07D405/12; C07D413/06;C07D471/04; C07D209/88; C07D401/12 | Oldestpriority date: 2009-01-09 | Publication date: 2016-03-08

Score: 19.449032 | Text size: 325720 | Find: similardocuments

from ChemDiv,Inc. Example 591-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol[[image:EMI-C00108]] Purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00109]] Purchased from ChemDiv, Inc. Example 611-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00110]] Purchased fromChemDiv, Inc. Example 621-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00111]] Purchased from ChemDiv, Inc. Example 631-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00112]] Purchased from ChemDiv, Inc. Example

Tetrahydrocarbazoles as active agents for inhibiting VEGF production bytranslational control

William Lennox[US];Hongyan Qi [US]; Duck-Hyung Lee[KR];Soongyu Choi[US];Young-Choon Moon[US]

Publicationdate: 2016-03-01 | Patent publication No.: US-09271960-B2|Assignees: PTC Therapeutics, Inc. [US] | IPC: A61K31/403; C07D209/90; C07D209/08; C07D471/04; A61K31/343; A61K31/4035;A61K31/407; A61K31/4162; A61K31/4184; A61K31/4188; A61K31/424; A61K31/4245;A61K31/506; A61K31/5377 | Oldestpriority date: 2004-11-23 | Publication date: 2016-03-01

Score: 19.295942 | Text size: 171253 | Find: similardocuments

ChemBridge5133291 [[image:EMI-C00301]] ChemBridge 5309760 [[image:EMI-C00302]] ChemDiv 8010-1969[[image:EMI-C00303]] ChemBridge 5259158 [[image:EMI-C00304]] Tripos 2000-13782[[image:EMI-C00305]] Chem Div 3606-0172 [[image:EMI-C00306]] ChemDiv 3474-0005[[image:EMI-C00307]] ChemDiv 0075-0033 [[image:EMI-C00308]] ChemDiv 3606-0516[[image:EMI-C00309]] Tripos 2000-12661 [[image:EMI-C00310]] Tripos ...ChemBridge 7111705 [[image:EMI-C00323]] ChemBridge 5277652[[image:EMI-C00324]] ChemDiv3474-0005 [[image:EMI-C00325]] ChemDiv 3606-0161[[image:EMI-C00326]] ChemDiv 8005-8953 REFERENCES 1. CarmelietP. Angiogenesis in health and disease. Nat Med.

Compounds for modulating TLR2

Robert W.Finberg [US]; Evelyn A.Kurt-Jones [US]; Shenghua Zhou[US]

Publicationdate: 2016-03-01 | Patent publication No.: US-09271972-B2|Assignees: University of Massachusetts [US] | IPC: A61K31/423; A61K31/454; A61K31/4725; A61K31/496; A61K31/42; A61K31/4245;A61K31/505; A61K31/551; A61K31/429; A61K31/443; A61K31/4433; A61K31/4439;A61K31/4535; A61K31/4745; A61K31/506 | Oldestpriority date: 2009-11-18 | Publication date: 2016-03-01

Score: 15.5924425 | Text size: 143563 | Find: similardocuments

Othercommercial sources include ChemDiv, ChemBridge, Aurora, Tim Tec,and Scientific exchange product list. ... Compound libraries screened includedthose from ChemDiv, Maybridge, ChemBridge, Biomol-TimTec, and someFungal Extracts.

USE OF SMALL MOLECULE INHIBITORS TARGETING EYA TYROSINE PHOSPHATASE

Rashmi HEGDE[US]

Score: 10.928354 | Text size: 184364 | Find: similardocuments

L129305) andcompound 1b from ChemDiv (cat. no. 3039-0682).

PYRAZOLES

SCHINDLER,Rudolf [DE];LANKAU,Hans-Joachim [DE]; HÖFGEN,Norbert [DE]; GRUNWALD,Christian [DE]; EGERLAND, Ute[DE];LANGEN, Barbara[DE];DOST, Rita [DE]; HAGE, Thorsten[DE];WARD, Simon [GB]

Publicationdate: 2016-02-18 | Patent publication No.: WO-2016025918-A1|Assignees: JANSSEN PHARMACEUTICALS, INC. [US] | IPC:C07D231/12; C07D403/06; A61K31/4155; A61P25/00 | Oldest priority date: 2014-08-15 | Publication date: 2016-02-18

Score: 18.76633 | Text size: 141796 | Find: similardocuments

fromFluorochem, order ID: 313369 ■ 4-(chloroethyl)-3,5-dimethyl-1H-pyrazole,available from ChemDiv, order ID: BB01- 4360 ■3-(chloromethyl)-1H-pyrazole hydrochloride, available from ChemDiv,order ID: BB20- 2557 ■ 4-(chloromethyl)-1-ethyl-1H-pyrazolehydrochloride, available from ChemDiv, order ID: BB57-1549 ■5-(chloromethyl)-1-ethyl-1H-pyrazole hydrochloride, available from ChemDiv,order ID: BB57-3435 ■ 3-(chloromethyl)-1-cyclopentyl-1H-pyrazole,available from Enamine, order ... temperature for 20 minutes, then 4-(2-chloro-ethyl)-3,5-dimethyl-1H-pyrazole (159 mg, 1.0 mmol) (ChemDiv, BB01-4360)was added. The reaction mixture was stirred at room temperature for 20 hours.

OSTEOCALCIN AS A TREATMENT FOR COGNITIVE DISORDERS

THE TRUSTEES OFCOLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US]; THE TRUSTEES OFCOLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US]; Gerard KARSENTY[US];Franck OURY [US]

Publicationdate: 2016-02-18 | Patent publication No.: US-20160045571-A1|Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US] | IPC: A61K38/22;G01N33/68 | Oldestpriority date: 2013-03-15 | Publication date: 2016-02-18

Score: 10.089907 | Text size: 302229 | Find: similardocuments

COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA

JolantaGrembecka [US]; Tomasz Cierpicki[US];Jay Hess [US]

Publicationdate: 2016-02-18 | Patent publication No.: US-20160045504-A1|Assignees: The Regents of the University of Michigan [US]; University of VirginiaPatent Foundation [US] | IPC: A61K31/519; A61K31/551; A61K31/5513; A61K31/5377 | Oldest priority date: 2009-09-04 |Publicationdate: 2016-02-18

Score: 20.573181 | Text size: 69866 | Find: similardocuments

assay withFLSNMLL (μM)Vendor/Cat # IC50 in HTRF assay (μM) Compound 32[[image:EMI-C00064]] 13ChemDiv Inc. Cat # 4780- 0051 7 Compound 33 [[image:EMI-C00065]]29 ChemDiv Inc. Cat # 5742- 0717 28 Compound 34[[image:EMI-C00066]] 12 ChemDiv Inc. Cat # 3393- 0109 NDCompound 35 [[image:EMI-C00067]] 35 ChemDiv Inc. Cat # 3393-0126 ND Compound 36 [[image:EMI-C00068]] 63 ChemDiv Inc. Cat #3170- 5216 ND Compound 37 [[image:EMI-C00069]] 100 ChemDiv Inc. Cat# 3404- 5359 ND Compound 38 [[image:EMI-C00070]] 115 ChemBridge Cat # 6369841ND Compound 39 [[image:EMI-C00071]] 230 ChemDiv Inc. Cat #3170- 5232 ND Compound 40 [[image:EMI-C00072]] NA ChemDiv Inc. Cat# 5531- 8211 ND Compound 41 [[image:EMI-C00073]] NA ChemDiv Inc. Cat# 3770- 0060 ND Compound 84 [[image:EMI-C00074]] 100

CELLULAR DISCOVERY PLATFORM FOR NEURODEGENERATIVE DISEASES

Susan L.Lindquist [US]; Vikram Khurana[US];Chee-Yeun Chung[US]

Score: 7.2924438 | Text size: 554847 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

SCHIZOPHRENIA-ASSOCIATED GENETIC LOCI IDENTIFIED IN GENOME WIDEASSOCIATION STUDIES AND METHODS OF USE THEREOF

Hakon Hakonarson[US];Patrick Sleiman[US];Xiao Chang [US]

Score: 13.10661 | Text size: 152842 | Find: similardocuments

Austria),BioFocus DPI (Switzerland), Bionet (Camelford, UK), Chembridge (San Diego,Calif.), ChemDiv (San Diego, Calif.

QUINAZOLINONE ANTIBIOTICS

Mayland CHANG[US];ShahriarMOBASHERY [US]; Renee BOULEY[US]

Publicationdate: 2016-02-04 | Patent publication No.: US-20160031832-A1|Assignees: University of Notre Dame Du Lac [US] | IPC:C07D239/91; C07D401/06; C07D405/06; A61K45/06; A61K31/519; C07D401/12;A61K31/5377; A61K31/517; C07D471/04 | Oldestpriority date:2013-03-05 | Publication date: 2016-02-04

Score: 15.5924425 | Text size: 138708 | Find: similardocuments

BENZIMIDAZOLE DERIVATIVES AND USES THEREOF

Susan L.Lindquist [US]; Stephen L.Buchwald [US]; Daniel Tardiff[US];Nathan Jui [US]

Publicationdate: 2016-02-04 | Patent publication No.: US-20160031824-A1|Assignees: Whitehead Institute for Biomedical Research [US]; Massachusetts Instituteof Technology [US] | IPC: C07D235/16; C07D405/04; C07D403/04; C07D401/12; C07D409/12 | Oldest priority date:2013-03-15 | Publication date: 2016-02-04

Score: 10.354719 | Text size: 275463 | Find: similardocuments

describedherein. [[image:EMI-C00079]] The original screen hit compound, ABI, waspurchased from ChemDiv(K783-0286). Subsequent synthesis was performed according to thefollowing strategy.

METHODS OF TREATING MUSCULAR DYSTROPHY

Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2016-02-04 | Patent publication No.: US-20160030390-A1|Assignees: Board of Regents of the Nevada System of Higher Ed ucation on behalf of theUniversity of Nevada Ren [US] | IPC: A61K31/404; A61K45/06 | Oldestpriority date: 2013-03-15 | Publication date: 2016-02-04

Score: 10.089907 | Text size: 348634 | Find: similardocuments

et al.,2006). 2) DIVERSet library (Chembridge Corp., San Diego, Calif.) and compoundsfrom the ChemDivlibrary. 3) LOPAC library (Sigma-RPI) consists of1280 pharmaceutically active compounds.

Antimicrobial compounds

Terence Moy [US]; Annie Conery[US];Kim Lewis [US]; Frederick M.Ausubel [US]; ReadPukkila-Worley [US]

Publicationdate: 2016-01-26 | Patent publication No.: US-09241928-B2|Assignees: The General Hospital Corporation [US]; Northeastern University [US] | IPC: A61K31/44;A61K31/427; A61K31/4427; A61K31/4725; A61K31/501 | Oldest priority date: 2009-06-26 | Publication date: 2016-01-26

Score: 18.178576 | Text size: 80806 | Find: similardocuments

Biology Program,Broad Institute, Cambridge, Mass.), ChemBridge kinases (San Diego,Calif.), ChemDiv (San Diego, Calif.), TimTec (Newark, Del. ...Synthesis (DOS) 11,666 1 0.01% ChemBridge kinases Commercial compounds: 8,24021 0.27% ChemDiv 11,616 12 0.10% TimTec 8,512 7 0.08%MayBridge 5,448 3 0.06% ChemBridge 704 1 0.14% Total 53,946b ... Example 6Antimicrobial Assay Methods Compounds 6, 7, 15 were purchased from TimTecand ChemDiv, dissolved in DMSO at a concentration of 5 or 10 mg/ml,and further diluted in DMSO as indicated.

AMYLOID BETA EXPRESSION CONSTRUCTSAND USES THEREFOR

Aftabul Haque[US];Susan L.Lindquist [US]

Publicationdate: 2015-12-17 | Patent publication No.: US-20150361148-A1|Assignees: Whitehead Institute for Biomedical Research [US] | IPC: C07K14/47;C12N15/85; C12Q1/18; C12N15/81 | Oldestpriority date: 2014-06-13 | Publication date: 2015-12-17

Score: 13.10661 | Text size: 157881 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

AMYLOID BETA EXPRESSION CONSTRUCTS AND USES THEREFOR

HAQUE, Aftabul[US];LINDQUIST, SusanL. [US]

Score: 13.10661 | Text size: 161745 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

POSITIVE ALLOSTERIC MODULATORS OF MGLUR3

Justin POTNICK[US]

Publicationdate: 2015-12-17 | Patent publication No.: US-20150361046-A1|Assignees: Merck Patent GmbH [DE] | IPC: C07D217/26; C07D213/85; A61K31/438; A61K31/472; C07D495/04; C07D491/052;A61K31/5377 | Oldestpriority date: 2013-02-04 | Publication date:2015-12-17

Score: 17.506392 | Text size: 102331 | Find: similardocuments

Therapeutic compounds for blocking DNA synthesis of POX viruses

Robert P.Ricciardi [US]

Publicationdate: 2015-12-15 | Patent publication No.: US-09211296-B2|Assignees: The Trustees of the University of Pennsylvania [US] |IPC: A61K31/65; A61K31/095; A61K31/166; A61K31/198; A61K31/426; A61K31/10;A61K31/341; A61K31/351; A61K31/352; A61K31/357; A61K31/42; A61K31/427;A61K31/429; A61K31/473; A61K31/496; A61K31/519 | Oldest priority date: 2007-02-06 | Publication date: 2015-12-15

Score: 17.610455 | Text size: 174477 | Find: similardocuments

A total of45,832 chemical compounds from the following libraries: ChemDiv 3(16,544 compounds), MixCommercial 5 (268 compounds), Maybridge 4 (4,576compounds), ActiMol ... 59 (6.9%) 57 (6.7%) 54 (6.3%) ICBG Fungal Extracts 2460 18 (3.9%) 30 (6.5%) 24 (5.2%) Synthetic ChemDiv 3 16,54421 (0.1%) 64 (0.4%) 89 (0.5%) Compounds MixCommercial 5 268 0 (0.0%) 0 (0.0%) 1(0. ... A total of 45832 synthetic compounds, representing 11 independentlibraries (ChemDiv 3 (16544 compounds), MixCommercial 5 (268compounds), Maybridge 4 (4576 compounds), ActiMol TimTec ... or failed to blockviral infection. bThe synthetic compounds belong to the followinglibraries: ChemDiv 3 (library 1); Maybridge 4 (library 3);ActiMol TimTec (library 4); and Bionet 2 (library 5).

Thioxothiazolidine inhibitors

Brian J. Geiss[US];Susan M. Keenan[US];Hillary Jo Beek[US]

Publicationdate: 2015-12-08 | Patent publication No.: US-09206412-B2|Assignees: Colorado State University Research Foundation [US] |IPC: A61K31/425; C12N9/99; C12N7/00; C12N9/12; A61K31/426; A61K9/00; A61K9/06;A61K9/20; A61K9/48; A61K31/427 | Oldestpriority date: 2012-05-31 | Publication date: 2015-12-08

Score: 16.068731 | Text size: 119734 | Find: similardocuments

Compoundswere obtained from ChemDiv and Hit2Lead. ... The fourcompounds from Table 1 and Scheme A were ordered in 5 mg quantities from ChemDiv andHit2Lead.

MULTIVALENT RAS BINDING COMPOUNDS

STOCKWELL, BrentR. [US];WELSCH, Matthew[US]

Publicationdate: 2015-12-03 | Patent publication No.: WO-2015184349-A2|Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US] | IPC: C07D401/00;C07D487/00; A01N43/40 | Oldestpriority date: 2014-05-30 | Publication date: 2015-12-03

Score: 10.928354 | Text size: 237783 | Find: similardocuments

availablecompounds were compiled from the inventories of Asinex, Enamine,Chembridge, ChemDiv, IBS, Life, Maybridge and TimTec.

RNF41 AS A BIOMARKER PREDICTING RESPONSE TO LENALIDOMIDE IN NON-DEL(5Q)MDS

Alan List [US]

Publicationdate: 2015-12-03 | Patent publication No.: US-20150344953-A1|Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: C12Q1/68;G01N33/573 | Oldestpriority date: 2012-12-05 | Publication date: 2015-12-03

Score: 14.831028 | Text size: 44182 | Find: similardocuments

Corporation(16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA,www.chembridge.com); ChemDiv (6605 Nancy Ridge Drive, SanDiego, Calif.

Materials and methods for inhibiting mamalian S-nitrosoglutathionereductase

Paresh Sanghani[US]

Publicationdate: 2015-12-01 | Patent publication No.: US-09198909-B1|Assignees: Indiana University Research and Technology Corporation [US] | IPC: A61K31/519;A61K31/402; A61K31/404 | Oldestpriority date: 2007-12-13 | Publication date: 2015-12-01

Score: 13.793969 | Text size: 77697 | Find: similardocuments

Thescreening for GSNOR inhibitors was performed using a library of 60,000compounds from ChemDiv Inc in the Chemical Genomics Corefacility at Indiana University.

PRPK-TPRKB modulators and uses thereof

Eun Sun Park[US];Henry E. Pelish[US];Astrid S. Clarke[US];Grace L.Williams [US]; Maria PaolaCastaldi [US]; AlexanderArefolov [US]; Jennifer E. Ring[US];Matthew D. Shair[US];Randall W. King[US]

Score: 14.450268 | Text size: 236832 | Find: similardocuments

commercialvendors such as ChemBridge Libraries (chembridge.com), BIOMOL International,ASINEX,ChemDiv, ChemDB, ICCB-Longwood. ... commercial vendors such asChemBridge Libraries (chembridge.com), BIOMOL International, ASINEX, ChemDiv,ChemDB, ICCB-Longwood or alternatively synthesized de novo.

CARBOXAMIDE DERIVATIVES

ARISTA, Luca[CH];COTESTA, Simona[CH];D'ALESSANDRO, Pier [CH]; D'SOUZA,Anne-marie [GB]; LATTMANN, Rene[CH];LIZOS, Dimitrios[CH];PULZ, Robert,Alexander [CH]; ROONEY, Lisa,Ann [GB];SMITH, Nichola[GB];TAYLOR, Jessica,Louise [GB];TROXLER, Thomas,J. [CH];ARISTA, Luca[CH];COTESTA, Simona[CH];D'ALESSANDRO, Pier [CH]; D'SOUZA,Anne-marie [GB]; LATTMANN, Rene [CH]; LIZOS, Dimitrios[CH];PULZ, Robert,Alexander [CH]; ROONEY, Lisa,Ann [GB];SMITH, Nichola[GB];TAYLOR, Jessica,Louise [GB];TROXLER, Thomas,J. [CH]

Publicationdate: 2015-11-19 | Patent publication No.: WO-2015173656-A1|Assignees: NOVARTIS AG [CH] | IPC: C07D403/12; A61K31/4192; A61P9/12; A61P19/02; A61P19/04; A61P19/08;C07D413/14; C07D413/12 | Oldestpriority date: 2014-05-14 | Publication date: 2015-11-19

Score: 15.5924425 | Text size: 161894 | Find: similardocuments

H-pyrazol-4-yl)-5-(4-fluorophenyl)isoxazole-3-carboxamide (registry number 688050-41-1;Library: ChemDiv. ... H-pyrazol-4-yl)-5-(3-chlorophenyl)isoxazole-3-carboxamide (registry number 912760-79-3;Library: ChemDiv.

SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INHIBITORS

VERKMAN, Alan,S. [US];ESTEVA-FONT,Cristina [US]

Score: 12.484504 | Text size: 145954 | Find: similardocuments

screeningwas done using a collection of 50,000 chemically diverse, drug-like compounds from ChemDiv (SanDiego, CA).

PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF

Daniel A.Lawrence [US]; Cory Emal [US]; Ashley Reinke[US];Shih-Hon Li [US]; Mark Warnock[US];GregoryAbernathy [US]

Publicationdate: 2015-11-05 | Patent publication No.: US-20150315178-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]; EASTERN MICHIGAN UNIVERSITY[US] |IPC: C07D417/04; C07C275/64; C07D209/34; C07D249/08; C07D277/34; C07D271/113;C07C233/56 | Oldestpriority date: 2012-10-31 | Publication date: 2015-11-05

Score: 11.918776 | Text size: 151332 | Find: similardocuments

ChemicalMethodologies Libraries Development (Boston University), Maybridge,Chembridge, ChemDiv, National Cancer Institute-DevelopmentTherapeutics Program Library, the Cayman Cannabinoid and

SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATINGCELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATINGDISORDERS

Loren D.Walensky [US]; Michelle L.Stewart [US]; Nicole Cohen[US]

Publicationdate: 2015-11-05 | Patent publication No.: US-20150315211-A1|Assignees: Dana-Farber Cancer Institute, Inc. [US] | IPC:C07D513/04; C07D409/12; C07C311/20; C07D409/14; C07D401/12; C07D413/14;C07D405/14; C07D417/14; C07D307/54; C07D405/12; C07D409/06; C07D413/06;C07D279/06; C07D327/04; C07D239/60; C07D403/06; C07D277/34; C07D417/04;C07C337/08; C07D249/12 | Oldestpriority date: 2010-01-29 | Publication date: 2015-11-05

Score: 11.918776 | Text size: 167565 | Find: similardocuments

CellularBiology at Harvard Medical School and employed commercial libraries (Asinex,Chembridge,ChemDiv, Enamine, Life Chemicals, and Maybridge).

COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER

Alan E.Tomkinson [US]; Helen Xi Chen[US];BarbaraDziegielewska [US]; Alexander D.Mackerell [US]; Shijun Zhong[US];Gerald M. Wilson[US]

Publicationdate: 2015-11-05 | Patent publication No.: US-20150313898-A1|Assignees: University of Maryland, Baltimore [US] | IPC:A61K31/505; G06F19/16; A61K31/165; G06F19/00; A61K31/255; A61N5/10;G01N21/64; C40B30/02; A61K31/166 | Oldestpriority date: 2007-04-10 | Publication date: 2015-11-05

Score: 12.892465 | Text size: 141052 | Find: similardocuments

Compoundsidentified by CADD screening were purchased from ChemBridge, ChemDiv,MayBridge, MDD, Nanosyn, Specs, Timtec, and Tripos.

Inhibitors of phosphodiesterase 11 (PDE11)

Charles StuartHoffman [US]; Ozge Ceyhan [US]

Publicationdate: 2015-11-03 | Patent publication No.: US-09173884-B2|Assignees: Trustees of Boston College [US] | IPC: C07D495/04; A61K31/519; C07D513/04; A61K45/06; A61K31/416; A61K31/437;A61K31/53; A61K31/573 | Oldestpriority date: 2011-11-30 | Publication date: 2015-11-03

Score: 14.96154 | Text size: 330160 | Find: similardocuments

1 (0.8%; 68hits from 8,518 compounds), Chembridge 3 (0.7%; 74 hits from 10,560 compounds),and ChemDiv6 (0.64%; 283 from 44,000 compounds) libraries. Incontrast, the lowest frequency of hits was observed in theChemDiv 1library (0. ... by four different companies (BC11-15, Enamine T0515-1965;BC11-19, Maybridge BTB 12009; BC11-28, ChemDiv K405-0344;BC11-38, Life Chemicals F0579-0060).

SUBSTITUTED ISOXAZOLE AMIDE COMPOUNDS AS INHIBITORS OF STEAROYL-COADESATURASE 1 (SCD1)

Shawn DavidErickson [US]; Paul Gillespie[US];Eric Mertz [US]

Score: 16.068731 | Text size: 135752 | Find: similardocuments

acid ethylester, the compound of formula 5, which is commercially available from vendorssuch as ChemDiv, Inc., 6605 Nancy Ridge Dr, San Diego, Calif.,92121, USA. ... acid ethyl ester (available from ChemDiv Inc., 6605Nancy Ridge Dr, San Diego, Calif., 92121, USA; 15 g, 60.

COMPOSITIONS OF ALDH1A1 INHIBITORS AND METHODS OF USE IN TREATING CANCER

Thomas D. Hurley[US];Daniela Matei[US]

Publicationdate: 2015-10-29 | Patent publication No.: US-20150306108-A1|Assignees: Indiana University Research & Technology Corporation [US] | IPC: A61K31/522;A61K31/277; A61K31/4184; A61K31/519 | Oldestpriority date: 2014-01-31 | Publication date: 2015-10-29

Score: 19.148819 | Text size: 136272 | Find: similardocuments

The chemicallibrary consisted of 64,000 compounds from ChemDiv Corp (SanDiego, Calif.) at a final concentration of 10 μM. ... Hits from the HTS wereordered from ChemDiv to determine if they had any effect onaldehyde oxidation and whether they were selective for ... Compounds werepurchased from ChemDivCorp. (San Diego, Calif.) and were >95%pure based on the NMR spectra provided by the vendor. ... We used a novelALDH1A1 inhibitor (CM037) identified through high throughput screening ofthe ChemDiv library and the less selective inhibitor DEAB.CM037 has a molecular weight of 431. ... The ALDH1A1 inhibitor (CM037) wasfrom ChemDiv (San Diego, Calif.), having >95% purity. CellCultures.

Benzodiazepine compounds with anti-flavivirus activity

Andrea Cuconati[US];Jinhong Chang[US];Timothy M. Block[US];Ju-Tao Guo [US]

Publicationdate: 2015-10-27 | Patent publication No.: US-09168260-B2|Assignees: Baruch S. Blumberg Institute [US]; Drexel University [US] | IPC: A61K31/5513;C07D243/24; C12Q1/70; C12Q1/68 | Oldestpriority date: 2012-02-24 | Publication date: 2015-10-27

Score: 15.717271 | Text size: 19074 | Find: similardocuments

EXAMPLE 1High Throughput Screening Compound library: 26,900 compounds from a library (ChemDivInc.) were tested at a single concentration of 10 micromolar.

Genetic Alterations on Chromosomes 21Q, 6Q and 15Q and Methods of UseThereof for the Diagnosis and Treatment of Type 1 Diabetes

Hakon Hakonarson[US];Struan F.A.Grant [US];JonathanBradfield [US]; ConstantinPolychronakos [US]; Hui-Qi Qu [CA]

Score: 13.10661 | Text size: 137403 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

IN SILICO IDENTIFICATION OF CANCER MOLECULAR SIGNALING PATHWAYS AND DRUGCANDIDATES

Johnathan M.Lancaster [US]; Yin Xiong [US]

Publicationdate: 2015-10-22 | Patent publication No.: US-20150302140-A1|Assignees: H. LEE MOFFIT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: G06F19/12;G06F19/20 | Oldestpriority date: 2012-11-02 | Publication date: 2015-10-22

Score: 10.928354 | Text size: 178424 | Find: similardocuments

Corporation(16981 Via Tazon, Suite G, San Diego, Calif., 92127, USA, www.chembridge.com); ChemDiv (6605Nancy Ridge Drive, San Diego, Calif.

SWEET FLAVOR MODIFIER

CatherineTachdjian [US]; Xiao Qing Tang[US];Donald S.Karanewsky [US]; Guy Servant [US]; Xiaodong Li [US]; Feng Zhang [US]; Qing Chen [US];Hong Zhang [US]; Timothy Davis[US];VincentDarmohusodo [US]; Melissa Wong[US];Victor Selchau[US]

Score: 9.838301 | Text size: 290065 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

Sweet flavor modifier

CatherineTachdjian [US]; DonaldKaranewsky [US]; Sara Werner [US]; VincentDarmohusodo [US]; Jeff Yamamoto[US]

Score: 10.633806 | Text size: 265967 | Find: similardocuments

TCI Americaof Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridgeof San Diego, Calif.

METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES ANDCONDITIONS

LARSEN, Scott D.[US];BELL, Jessica L.[US];NEUBIG, Richard[US];HUTCHINGS, Kim[US]

Publicationdate: 2015-09-17 | Patent publication No.: WO-2015138326-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]; BOARD OF TRUSTEES OFMICHIGAN STATE UNIVERSITY [US] | IPC: A61K31/4245 | Oldestpriority date: 2014-03-10 | Publication date:2015-09-17

Score: 19.89482 | Text size: 138918 | Find: similardocuments

Table 2 Rhoinhibition by a variety of compounds [[image:imgf000049_0002]] ChemDiv (SanH [[image:imgf000050_0001]] 105557 5.2 Diego, CA) if ChemDiv (San107983 >100 Diego, CA) ChemDiv (San 111085 >100 Diego,CA) ChemDiv (San [[image:imgf000050_0002]] 114898 6.7 Diego,CA) CH., ChemDiv (San OH 123851 1.5 Diego, CA) ChemDiv (San123852 0.34 Diego, CA) [[image:imgf000051_0001]] 123867 >100 Diego,CA) ChemDiv (San 123869 87 Diego, CA) t ChemDiv (San123873 >100 Diego, CA) ChemDiv (San 211911 3.6 Diego, CA)[[image:imgf000052_0001]] ChemDiv (San 211912 >100 Diego,CA) ChemDiv (San 211913 >100 Diego, CA) ChemDiv (San[[image:imgf000052_0002]] 211914 >100 Diego, CA) [[image:imgf000053_0001]]

SWEET FLAVOR MODIFIER

SaraAdamski-Werner [US]; VincentDarmohusodo [US]; CatherineTachdjian [US]; DonaldKaranewsky [US]

Score: 12.484504 | Text size: 116215 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

Novel Gene Targets Associated with Amyotrophic Lateral Sclerosis andMethods of Use Thereof

Aaron D. Gitler[US]

Score: 12.290053 | Text size: 156490 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

METHODS AND COMPOSITIONS FOR INHIBITING RHO/MRTF-MEDIATED DISEASES ANDCONDITIONS

Scott D. Larsen[US];Jessica L. Bell[US];Richard Neubig[US];Kim Hutchings[US]

Publicationdate: 2015-09-10 | Patent publication No.: US-20150250769-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]; BOARD OF TRUSTEES OFMICHIGAN STATE UNIVERSITY [US] | IPC: A61K31/4245; A61K45/06 | Oldestpriority date: 2014-03-10 |Publicationdate: 2015-09-10

Score: 20.643097 | Text size: 136952 | Find: similardocuments

Rhoinhibition by a variety of compounds IDSRE-Luciferase IC50 (uM) SourceStructure 20321 >100 ChemDiv(San Diego, CA) [[image:EMI-C00023]]58146 0.18 ChemDiv (San Diego, CA) [[image:EMI-C00024]] 581500.004ChemDiv (San Diego, CA) [[image:EMI-C00025]] 105557 5.2 ChemDiv (SanDiego, CA) [[image:EMI-C00026]] 107983 >100 ChemDiv (SanDiego, CA) [[image:EMI-C00027]] 111085 >100 ChemDiv (SanDiego, CA) [[image:EMI-C00028]] 114898 6.7 ChemDiv (San Diego,CA) [[image:EMI-C00029]] 123851 1.5 ChemDiv (San Diego, CA)[[image:EMI-C00030]] 123852 0.34 ChemDiv (San Diego, CA)[[image:EMI-C00031]] 123853 6.4ChemDiv (San Diego, CA)[[image:EMI-C00032]] 123855 0.16 ChemDiv (San Diego, CA)[[image:EMI-C00033]] 123859 3.5 ChemDiv (San Diego, CA)[[image:EMI-C00034]] 123860 43 ChemDiv (San Diego, CA)

Generation of Airway and Lung Progenitors and Epithelial Cells andThree-Dimensional Anterior Foregut Spheres

Hans-WillemSnoeck [US];Sarah XuelianHuang [US];Ya-Wen Chen [US]; JaharBhattacharya [US]; Mohammad NaeemIslam [US]

Publicationdate: 2015-09-03 | Patent publication No.: US-20150247124-A1|Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US] | IPC: C12N5/071;G01N33/50; G01N33/68 | Oldestpriority date: 2012-07-24 | Publication date: 2015-09-03

Score: 12.892465 | Text size: 116000 | Find: similardocuments

(A divisionof Key Organics Limited), Camelford, UK; ChemBridge Corporation, San Diego,Calif.; ChemDiv Inc, San Diego, Calif.; ChemRx AdvancedTechnologies, South San Francisco, Calif.; ComGenex Inc.

METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITIONCONTAINING STABILIZED SWEET ENHANCER

CatherineTachdjian [US]; DonaldKaranewsky [US]; Xiao Qing Tang[US];Hanghui Liu [US]

Score: 8.557886 | Text size: 466643 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

METHODS AND COMPOSITIONS FOR INHIBITING GRAM POSITIVE BACTERIA

Stefan Richter[US];Dominique M.Missiakas [US]; Olaf Schneewind[US]

Score: 11.569273 | Text size: 215967 | Find: similardocuments

Smallmolecule libraries from different vendors (Asinex, ChemBridge, ChemDiv,Enamine, LifeChemicals, Maybridge, TimTec) were tested in duplicate at theNational Screening

METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF DISEASES MEDIATEDBY THE NRP-1/OBR COMPLEX SIGNALING PATHWAY

BELAID-CHOUCAIR,Zakia [FR];HERMINE, Olivier[FR];GARRIDO-FLEURY,Carmen [FR];COCHET, Claude[FR];FILHOL-COCHET,Odile [FR];SEIGNEURIC,Renaud [FR]

Publicationdate: 2015-08-27 | Patent publication No.: WO-2015124588-A1|Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHEMÉDICALE) [FR]; UNIVERSITÉ PARIS DESCARTES [FR]; FONDATIONIMAGINE [FR]; ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) [FR]; CENTRENATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR]; UNIVERSITÉ GRENOBLE IJOSEPH FOURIER [FR]; COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUXÉNERGIES ALTERNATIVES [FR]; UNIVERSITÉ DE BOURGOGNE [FR] | IPC: G01N33/574;G01N33/50 | Oldestpriority date: 2014-02-18 | Publication date: 2015-08-27

Score: 12.290053 | Text size: 146320 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston- Salem, NC), ChemBridge (SanDiego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, TheNetherlands), Timtec (Newark, DE), or alternatively can be

Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of UseThereof

Yohannes T.Ghebremariam [US]; John P. Cooke[US]

Publicationdate: 2015-08-27 | Patent publication No.: US-20150238472-A1|Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/444;A61K31/4439 | Oldestpriority date: 2012-02-14 | Publication date: 2015-08-27

Score: 16.857985 | Text size: 227052 | Find: similardocuments

Center(HTBC) contains over 130,000 small molecules selected from diverse sourcesincluding Sigma,ChemDiv, MicroSource, ChemBridge, the NIH clinicalcollection (NIH CC), National Cancer Institute (NCI), ... compounds such asphenylmercuric acetate (IC50<0.78 μM) and quinone-type compoundssuch as ChemDiv2548-0707 (IC50=5.5 μM) and 2548-0703 (IC50=9.0 μM). ...showing inhibition of human DDAH-1 activity by selected small molecules usingthe CPM assay: A) ChemDiv Compound 2548-0707; B) ChemDiv Compound2548-0703; C) 4-MMP; and D) SCH-202676.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OR ELIMINATING BITTERTASTE

Kambiz Shekdar[US];Daniel Lavery[US];Joseph Gunnet[US];Jessica Langer[US];Jane V. Leland[US];David Hayashi[US];Peter H. Brown[US];Louise Slade[US];William P. Jones[US]

Publicationdate: 2015-08-27 | Patent publication No.: US-20150237900-A1|Assignees: CHROMOCELL CORPORATION [US]; KRAFT FOODS GROUP BRANDS LLC [US] | IPC: A23L1/22;C07D311/72; C07C69/78; C07D311/20; C07C63/06; A23L1/226; C07D311/22 | Oldest priority date:2010-04-15 | Publication date: 2015-08-27

Score: 8.557886 | Text size: 394748 | Find: similardocuments

wereobtained from commercial vendors for synthetic and natural compounds, includingVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

METHOD FOR REDUCING BCL2 GENE EXPRESSION

HURLEY, Laurence[US];KENDRICK,Samantha [US]; GOKHALE, Vijay[US];YANG, Danzhou[US];AGRAWAL,Prashansa [US]; HURLEY, Laurence[US];KENDRICK,Samantha [US]; GOKHALE, Vijay[US];YANG, Danzhou[US];AGRAWAL, Prashansa[US]

Publicationdate: 2015-08-20 | Patent publication No.: WO-2015123617-A1|Assignees: ARIZONA BOARD OF REGENTS FOR THE UNIVERSITY OF ARIZONA [US] | IPC: A61K45/06;A61K45/00; A61K31/4453; A61K31/56; A61K31/575; A61K31/58; A61P35/00 | Oldest priority date: 2014-02-14 | Publication date: 2015-08-20

Score: 12.685205 | Text size: 136375 | Find: similardocuments

This led toa secondary screening of an additional 14 steroidal compounds from ChemDiv,all of which either increased the FRET intensity or had no effect (eight of thecompounds that

METHOD FOR INCREASING BCL2 GENE EXPRESSION

HURLEY, Laurence[US];KENDRICK,Samantha [US]; GOKHALE, Vijay[US];KANG, Hyunjin[US];YANG, Danzhou[US];AGRAWAL,Prashansa [US];HURLEY, Laurence[US];KENDRICK,Samantha [US]; GOKHALE, Vijay[US];KANG, Hyunjin[US];YANG, Danzhou[US];AGRAWAL,Prashansa [US]

Publicationdate: 2015-08-20 | Patent publication No.: WO-2015123618-A1|Assignees: ARIZONA BOARD OF REGENTS FOR THE UNIVERSITY OF ARIZONA [US] | IPC: A61K45/06;A61K45/00; A61K31/4453; A61K31/56; A61K31/575; A61K31/58; A61P25/28 | Oldest priority date: 2014-02-14 | Publication date: 2015-08-20

Score: 12.685205 | Text size: 133390 | Find: similardocuments

This led toa secondary screening of an additional 14 steroidal compounds from ChemDiv,all of which either increased the FRET intensity or had no effect (eight of thecompounds that

Antibacterial Compound

Wilson, Francis,Xavier [GB];Johnson, Peter,David [GB];Vickers, Richard[GB];Storer, Richard[GB];Wynne, Graham,Michael [GB]; Roach, Alan,Geoffrey [GB]; De Moor, Olivier[GB];Dorgan, Colin,Richard [GB]; Davis, Paul,James [GB]

Score: 12.290053 | Text size: 131561 | Find: similardocuments

[M7-A7, Vol.26, No2, Jan 2006]. (ii) Commercial Compounds All compounds below werepurchased fromChemDiv:3,3'-(1H,1'H-5,5'-Bibenzo[d]imidazole-2,2'-diyl)dianiline (Compound 2).

External link

NETRIN-1 AND DEPENDENCE RECEPTOR PROTEINS AND METHODS OF USE

STETEFELD, Jorg[CA];STETEFELD, Jorg[CA]

Publicationdate: 2015-08-13 | Patent publication No.: WO-2015118514-A1|Assignees: UNIVERSITY OF MANITOBA [CA] | IPC: C07K14/47; A61K38/17; A61K39/395; A61P35/00; C07K16/18; C07K19/00;C12N5/07; C12N5/09 | Oldestpriority date: 2014-02-10 | Publication date:2015-08-13

Score: 13.10661 | Text size: 132116 | Find: similardocuments

and includeAMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridgeLibrary, ChemDivLibrary, Enamine Library, The Greenpharma NaturalCompound Library, Life Chemicals Library,

Inhibitors of filovirus entry into host cells

Arnab Basu [US]; Debra M. Mills[US];Norton P. Peet[US];John D. Williams[US]

Publicationdate: 2015-08-11 | Patent publication No.: US-09101635-B2|Assignees: MICROBIOTIX, INC. [US] | IPC: A61K31/18; A61K31/5513; C07D213/74; C07D215/40; C07D243/12; C07D249/10;C07D307/71; C07D405/06; C07D405/12; C07D405/14; C07D409/04; C07D471/04;C07D491/22 | Oldestpriority date: 2009-07-10 | Publication date: 2015-08-11

Score: 15.906768 | Text size: 120890 | Find: similardocuments

asChemBridge Corporation (San Diego, Calif., USA), Life Chemicals Inc.(Burlington, ON, Canada), ChemDiv Inc.(San Diego, Calif., USA), andTimtec LLC (Newark, Del., USA). ... Da, and obtained from several vendors:Chembridge (San Diego, Calif.), Timtec (Newark, Del.), and ChemDiv (SanDiego, Calif.

SMALL MOLECULE HAVING ANTIVIRAL PROPERTIES

EVANS, David[US]

Score: 16.139202 | Text size: 8197 | Find: similardocuments

and TZV Byusing Substructure searches (SSS) of chemical libraries available from vendorssuch as ChemDiv(San Diego, CA), ChemBridge, Enamine, MayBridge (UK)and others it is possible to identify and

Antiviral compounds and uses thereof

Megan Shaw [US]; Hans-HeinrichHoffmann [US]; AdolfoGarcia-Sastre [US]; Peter Palese[US]

Publicationdate: 2015-08-04 | Patent publication No.: US-09096585-B2|Assignees: Icahn School of Medicine at Mount Sinai [US] | IPC:A61K31/41; A61K31/515; A61K31/535; C07D413/14; A61K31/4245; C07D413/10;C07D413/12; A61K31/55; A61K31/5377 | Oldestpriority date:2010-05-28 | Publication date: 2015-08-04

Score: 13.4640045 | Text size: 303074 | Find: similardocuments

LeadCompound C2 was identified in a screen of the ChemDiv 4 sourcelibrary (14,677 Compounds; ChemDiv Inc., San Diego, Calif., USA).

Pro-neurogenic compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Publicationdate: 2015-08-04 | Patent publication No.: US-09095572-B2|Assignees: Board of Regents of The University of Texas System [US] | IPC: C07D209/82;A61K31/403; A61K31/404; A61K31/4045; A61K31/437; A61K31/4439; A61K31/506;C07D209/08; C07D209/86; C07D209/88; C07D401/06; C07D401/12; C07D403/06;C07D403/12; C07D405/12; C07D413/06; C07D471/04; C07D495/04; C07F5/02 | Oldest priority date: 2009-01-09 | Publication date: 2015-08-04

Score: 18.456491 | Text size: 553130 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00132]] This compound can be purchased from ChemDiv, Inc.Example61 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00133]] This compound can be purchased from ChemDiv, Inc. Example62 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00134]] This compound can be purchased from ChemDiv, Inc. Example63 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00135]] This compound can be purchased from ChemDiv, Inc. Example

Prolylhydroxylase inhibitors and methods of use

Ratan, Rajiv R[US];Gazaryan, Irina[US];Smirnova,Natalya [US]

Publicationdate: 2015-07-08 | Patent publication No.: EP-2891649-A1|Assignees: Cornell University [US] | IPC: C07D209/18; C07D401/12; A61K31/404; A61K31/4709; A61P9/00; A61P25/00 | Oldest priority date: 2010-02-23 | Publication date: 2015-07-08

Score: 15.906768 | Text size: 136835 | Find: similardocuments

160validated hits The screen of 85,000 compounds library (including those fromSpectrum, ChemDiv, AMRI, ChemBridge. ... Extended SAR analysisOxyquinolines were purchased from ChemDiv (San Diego, CA) andtested in 96-format plates with varied concentrations of an inhibitor (0.

External link

Tricyclic pyrazol amine derivatives

Pascale Gaillard[FR];IsabelleJeanclaude-Etter [CH]; Vincent Pomel[FR];Eric Sebille[FR];SeenisamyJeyaprakashnarayanan [IN]; MathildeMuzerelle [FR]

Score: 7.032474 | Text size: 693842 | Find: similardocuments

compound B1,referenced under the Registry Number 931355-99-6, is commercially availablefrom ChemDivCompany. This compound was not used for anypharmaceutical or medical indication.

Compounds that inhibit human DNA ligases and methods of treating cancer

Alan E.Tomkinson [US]; Helen Xi Chen[US];BarbaraDziegielewska [US]; Alexander D.Mackerell [US]; Shijun Zhong[US];Gerald M. Wilson[US]

Publicationdate: 2015-07-07 | Patent publication No.: US-09073896-B2|Assignees: University of Maryland, Baltimore [US] | IPC:A61K31/505; A61K31/15; A61K45/06; C07D407/12; A61K31/397; C07D307/68;A61K31/175; A61K31/341; A61K31/404; A61K31/41; A61K31/4184; A61K31/423;A61K31/4245; A61K31/428; A61K31/433; A61K31/436; A61K31/4439; A61K31/495;A61K31/553; C07D209/30; C07D235/28; C07D257/04; C07D263/58; C07D267/18;C07D271/12; C07D277/74; C07D285/14; C07D401/12 | Oldest priority date: 2007-04-10 |Publicationdate: 2015-07-07

Score: 13.10661 | Text size: 149893 | Find: similardocuments

Compoundsidentified by CADD screening were purchased from ChemBridge, ChemDiv,MayBridge, MDD, Nanosyn, Specs, Timtec, and Tripos.

ALPHA- AND GAMMA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICALCOMPOSITIONS THEREOF

Iwao Ojima [US]; Dale Deutsch[US];Martin Kaczocha[US];William T.Berger [US];Robert Rizzo[US];Trent E. Balius[US]

Publicationdate: 2015-07-02 | Patent publication No.: US-20150183715-A1|Assignees: The Research Foundation for The State University of New York [US] | IPC: C07C69/757;C07C67/48; G01N33/566; C07C67/08 | Oldestpriority date: 2012-07-20 | Publication date: 2015-07-02

Score: 19.862059 | Text size: 146997 | Find: similardocuments

EnergeticallyDOCK selected ligands from the ChemDiv library that did nothave unfavorable interaction, both VDW and ES, intrinsically selecting ... Thefollowing compounds are available from ChemDiv (San Diego,Calif., USA): StructureChemDiv ID Number [[image:EMI-C00037]] 8009-2334 [[image:EMI-C00038]] 8009- 3434 [[image:EMI-C00039]] ... acid was fromCayman Chemical (Ann Arbor, Mich.). 48 virtually screened test compoundsfrom ChemDiv, Inc. (Moscow, Russia). ... Competitors includedarachidonic acid, BMS309403, 48 test compounds from ChemDiv library,Compound 26 and Compound 49. ... Virtual Screening A high-throughput virtualscreening of over one million molecules from the ChemDiv subsetof the ZINC database (http://zinc.docking.

Cell based methods and systems for the identification of RNA regulatorysequences and compounds that modulate their functions

Matthew C.Pelligrini [US]

Score: 13.327991 | Text size: 118654 | Find: similardocuments

INHIBITORS OF THE NOTCH SIGNALLING PATHWAY AND SECRETION FOR USE INMEDICINE

ChristophKaether [DE]; AndreasKrämer [DE]

Publicationdate: 2015-06-25 | Patent publication No.: US-20150175548-A1|Assignees: Leibniz-Institut für Altersforschung Fritz-Lipmann -Institut e.V.(FLI) [DE] | IPC: C07D215/54 | Oldestpriority date: 2012-06-01 | Publication date: 2015-06-25

Score: 19.588453 | Text size: 141729 | Find: similardocuments

No.OrderIDand VendorMWFormulam/Z foundPurity MS FLI-06 1630-0135 ChemDiv 438.53C25H30N2O5 438 OK FLI-14 C329-0322 ChemDiv 512.81 C30H32N4O4512 OK FLI-15 C548-2756 ChemDiv* 405.49 C17H19N5O3S2 405 OK FLI-194464-0971 ChemDiv 565.70 C32H43N3O6 588 (M + Na+) OK FLI-20STK164160 Vitas-M 383.51 C21H25N3O2S 438 Impurity with M=438.6 FLI-24 (3)BAS00087237 Asinex 398.45 C22H26N2O5 398 OK FLI-25 (11) 1630-1646 ChemDiv 393.52C25H31NO3 393 OK FLI-27 (4) OSSL_264545 Princeton Biomol. Res. 426.51C24H30N2O5 426 OK FLI-28 (5) OSSK_158427 Princeton Biomol. Res. 452.23C26H32N2O5 452 OK *The ChemDiv entry contains C15H19CIN4O5S3,MW=466.02; the correct structure was determined by NMR.

MUCOADHESIVE DEVICES FOR DELIVERY OF ACTIVE AGENTS

Baruch Z. Harris[US];Vijay M.K.Murthy [US];David AdamSteinberg [US]; Rodney Pearlman[US];Howard BrianRosen [US];Robert SamuelLanger [US];Hila Esptein-Barash[US];Jonathan RobertBehr [US];Samir SureshMitragotri [US]

Publicationdate: 2015-06-25 | Patent publication No.: US-20150174076-A1|Assignees: Entrega, Inc. [US]; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K9/20; A61K47/38;A61K38/23; A61K47/36; A61K31/352; A61K38/28 | Oldest priority date: 2012-06-14 | Publication date: 2015-06-25

Score: 12.685205 | Text size: 122054 | Find: similardocuments

fromcommercial and academic sources, for example, from Sigma-Aldrich(www.sigmaaldrich.com), ChemDiv(www.chemdiv.com), Evotec(www.evotec.com), or ICCB (iccb.med.harvard.

Selective efflux inhibitors and related pharmaceutical compositions andmethods of treatment

Richard SmithLarson [US];Larry A. Sklar[US];Bruce S. Edwards[US];Juan JacobStrouse [US]; IrenaIvnitski-Steele [US]; Hadya M. Khawaja[US];Jerec WarrenRicci [US];Jeffrey Aube[US];JenniferElizabeth Golden [US]; Tuanli Yao [US]; Warren S. Weiner[US];Chad E.Schroeder [US]

Publicationdate: 2015-06-16 | Patent publication No.: US-09056111-B1|Assignees: STC.UNM [US]; UNIVERSITY OF KANSAS [US] | IPC:A01N43/90; A61K31/519; C07D487/00; A61K31/437; C07D487/04 | Oldest priority date: 2011-09-21 | Publication date: 2015-06-16

Score: 14.999643 | Text size: 227321 | Find: similardocuments

ALDEHYDE DEHYDROGENASE INHIBITORS AND METHODS OF USE THEREOF

HURLEY, Thomas,D. [US];CHEN, Che-Hong[US];MOCHLY-ROSEN,Daria [US]

Publicationdate: 2015-06-11 | Patent publication No.: WO-2015084731-A1|Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US];INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] | IPC: A01N43/38;A01N43/36; A61K31/40 | Oldestpriority date: 2013-12-02 | Publication date: 2015-06-11

Score: 15.970954 | Text size: 218385 | Find: similardocuments

Thefollowing compounds were purchased from ChemDiv for furtherscreening: 0764-0625, 1 -pentyl-2,3-dihydro- 1 H-indole-2,3 -dione (ALDiBl 7);... Inhibitors that emerged from the screens were purchased from ChemBridgeor ChemDiv and were designated ALDiBxx as they are as ALDHinhibitors and B designates that they are a ... this group of compounds, weobtained an additional 33 structurally similar analogs from ChemDivandChemBridge was obtained; the ability of these compounds to inhibit ALDHl Al,ALDH2 and ALDH3A1,

WNT PROTEIN SIGNALLING INHIBITORS

Lawrence Lum[US];Michael Roth[US];Baozhi Chen [US]; Michael Dodge[US];Chuo Chen [US]

Publicationdate: 2015-06-11 | Patent publication No.: US-20150157633-A1|Assignees: The Board of Regents of the University of Texas System [US] | IPC: A61K31/519;A61K31/495; A61K31/42; A61K31/4709; A61K45/06; A61K31/44; A61K31/4439;A61K31/453; A61K31/353; A61K31/444; A61K31/517 | Oldest priority date: 2012-05-11 | Publication date: 2015-06-11

Score: 12.685205 | Text size: 130688 | Find: similardocuments

TheUniversity of Texas Southwestern Medical Center chemical library is assembledfrom ChemDiv, ChemBridge, ComGenex, Prestwick, and TimT3kcollections.

METHODS TO IDENTIFY MODULATORS OF RYR CALCIUM CHANNELS

Razvan L. Cornea[US];Donald M. Bers[US];David D. Thomas[US];Gregory D.Gillispie [US]

Publicationdate: 2015-06-11 | Patent publication No.: US-20150160216-A1|Assignees: REGENTS OF THE UNIVERSITY OF MINNESOTA [US]; THE REGENTS OF THE UNIVERSITYOF CALIFORNIA [US] | IPC: G01N33/569 | Oldestpriority date: 2013-12-10 | Publication date: 2015-06-11

Score: 12.290053 | Text size: 159372 | Find: similardocuments

and includeAMRI library, AnalytiCon, BioFocus DPI Library, Chem-X-Infinity, ChemBridgeLibrary, ChemDivLibrary, Enamine Library, The Greenpharma NaturalCompound Library, Life Chemicals Library,

Compounds and assays for controlling Wnt activity

Dakai Liu [US]; Xiaofeng Li [US]; Richard Jin [US]; Yuaxin Liang[US];Wei Cheng [US]; RiddhiBhattacharyya [US]; Guangrong Zhang[US]

Publicationdate: 2015-06-09 | Patent publication No.: US-09052324-B2|Assignees: Enzo Biochem, Inc. [US] | IPC: A61K31/538; G01N33/68; C40B30/02; C07D265/28; C07D265/38; C07D265/34;A61K31/536 | Oldestpriority date: 2009-05-22 | Publication date: 2015-06-09

Score: 12.290053 | Text size: 191520 | Find: similardocuments

from the NCIdatabase/chemical library as well as commercial database/chemical librariesfrom ChemDiv, Inc.(San Diego, Calif.), Chembridge Corporation (SanDiego, Calif.

Sweet flavor modifier

Publicationdate: 2015-06-09 | Patent publication No.: US-09049878-B2|Assignees: Senomyx, Inc. [US] | IPC: A23L1/236; A23L1/22; A23L1/226; C07D215/54; C07D215/60; C07D401/12;C07D405/12; C07D471/04; C07D491/048; C07D495/04; A61K47/22 | Oldest priority date:2010-04-02 | Publication date: 2015-06-09

Score: 9.838301 | Text size: 311178 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

ANTIBACTERIAL COMPOUNDS

Francis XavierWILSON [GB];Peter DavidJohnson [GB]; Richard Vickers[GB];Richard Storer[GB];Graham MichaelWynne [GB];Alan GeoffreyRoach [GB];Olivier De Moor[GB];Colin Richard Dorgan[GB];Paul James Davis[GB]

Score: 12.484504 | Text size: 123721 | Find: similar documents

Vol. 26, No2, January 2006]. (ii) Commercial Compounds All compounds below were purchasedfromChemDiv:3,3′-(1H,1′H-5,5′-Bibenzo[d]imidazole-2,2′-diyl)dianiline(Compound 2).

METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS

Jay Jie-Qiang Wu[US]

Score: 12.685205 | Text size: 98587 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

Activators of protein phosphatase 5

Groll, Michael[DE];Richter, Klaus[DE];Haslbeck,Veronika [DE]; Striggow, Frank[DE];Martin, Helmuth[DE];Schmidt, Werner[DE];Weiwad, Matthias[DE];Fischer, Gunter[DE]

Publicationdate: 2015-06-03 | Patent publication No.: EP-2878677-A1|Assignees: Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) [DE];Technische Universität München [DE] | IPC: C12Q1/42 | Oldest priority date: 2013-11-28 | Publication date:2015-06-03

Score: 14.190399 | Text size: 203404 | Find: similardocuments

Allcompounds were purchased by ChemDiv (San Diego, California,USA). ... P5SA-1, P5SA-2, P5SA-3, P5SA-4 and P5SA-5 (see Fig. 1B for structure)were purchased from ChemDiv (San Diego, California, USA) withthe respective ChemDiv-Code 5638-0063, C301-7823, E635-0056,

External link

SMALL-MOLECULE INHIBITORS OF DENGUE VIRUS PROTEASES

Stanley J.Watowich [US]; Usha Viswanathan[US]

Score: 14.692947 | Text size: 60143 | Find: similardocuments

compoundsthat were available for purchase from either ChemBridge Corporation (San Diego,Calif.), ChemDiv Inc. (San Diego, Calif.), Ryan ScientificInc.

Methods and Compositions for Identifying and Validating Modulators ofCell Fate

Kambiz Shekdar[US];Dennis J.Sawchuk [US]; Jessica C.Langer [US]

Score: 10.354719 | Text size: 254599 | Find: similardocuments

Non-limitingexamples of small molecule libraries include LOPAC, TimTec, ChemDiv,Asinex and Ryan Scientific.

SWEET FLAVOR MODIFIER

CatherineTACHDJIAN [US]; Xiao Qing TANG[US];Donald S.KARANEWSKY [US]; Guy SERVANT [US]; Xiaodong LI [US]; Feng ZHANG [US]; Qing CHEN [US]; Hong ZHANG [US]; Timothy JamesDAVIS [US];VincentDARMOHUSODO [US]; Melissa WONG[US];Victor SELCHAU[US]

Score: 10.928354 | Text size: 193272 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

TETRAHYDROCARBAZOLES AS ACTIVE AGENTS FOR INHIBITING VEGF PRODUCTION BYTRANSLATIONAL CONTROL

William Lennox[US];Hongyan Qi [US]; Duck-Hyung Lee[KR];Soongyu Choi[US];Young-Choon Moon[US]

Publicationdate: 2015-05-21 | Patent publication No.: US-20150141418-A1|Assignees: PTC Therapeutics, Inc. [US] | IPC: A61K31/403; A61K31/4035; A61K31/5377; A61K31/343; A61K31/4184; A61K31/424;A61K31/4162; A61K31/4188; A61K31/506; A61K31/407; A61K31/4245 |Oldestpriority date: 2004-11-23 | Publication date: 2015-05-21

Score: 19.295942 | Text size: 173708 | Find: similardocuments

ChemBridge5133291 [[image:EMI-C00301]] ChemBridge 5309760 [[image:EMI-C00302]] ChemDiv 8010-1969[[image:EMI-C00303]] ChemBridge 5259158 [[image:EMI-C00304]] Tripos 2000-13782[[image:EMI-C00305]] Chem Div 3606-0172 [[image:EMI-C00306]] ChemDiv 3474-0005[[image:EMI-C00307]] ChemDiv 0075-0033[[image:EMI-C00308]] ChemDiv 3606-0516 [[image:EMI-C00309]]Tripos 2000-12661 [[image:EMI-C00310]] Tripos ... ChemBridge 7111705[[image:EMI-C00323]] ChemBridge 5277652 [[image:EMI-C00324]] ChemDiv3474-0005[[image:EMI-C00325]] ChemDiv 3606-0161[[image:EMI-C00326]] ChemDiv 8005-8953 REFERENCES 1. Carmeliet P. Angiogenesis in healthand disease. Nat Med.

FIBROSIS INHIBITING COMPOUNDS ANDMETHODS OF USE THEREOF IN THE PREVENTION OR TREATMENT OF FIBROSING DISEASES

GOMER, Richard,H. [US];COX, Nehemiah[US]

Publicationdate: 2015-04-02 | Patent publication No.: WO-2015048641-A2|Assignees: THE TEXAS A&M UNIVERSITY SYSTEM [US] | IPC:A01N43/00; A61K31/33; A61K31/41; A61K31/425; A61K31/38; A01N37/18;A61K31/16 | Oldestpriority date: 2013-09-30 | Publication date:2015-04-02

Score: 14.039395 | Text size: 67153 | Find: similardocuments

Compound 2(Cat#545- 1519) and compound 3 (Cat#4545-1530) were purchased from ChemDiv (SanDiego, CA).

COMPOSITIONS ASSOCIATED WITH AND METHODS OF MANAGING NEUTROPHIL MOVEMENT

GOMER, Richard,H. [US];COX, Nehemiah[US]

Score: 13.327991 | Text size: 86546 | Find: similardocuments

Compound 1(ChemBridge, San Diego, CA), and compound 3 (ChemDiv, San Diego, CA)were dissolved in demethyl sulfoxide (DMSO) (Sigma-Aldrich) to a final

NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI ORSWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF

CatherineTACHDJIAN [US]; Andrew P. PATRON[US];Sara L.ADAMSKI-WERNER [US]; Farid BAKIR [US]; Qing CHEN [US]; VincentDARMOHUSODO [US]; Stephen TerrenceHOBSON [US];Xiaodong LI [US]; Ming QI [CN]; Daniel H. ROGERS[US];Marketa RINNOVA[US];Guy SERVANT [US]; Xiao-Qing TANG[US];Mark ZOLLER [US]; David WALLACE[US];Amy XING [US]; Klaus GUBERNATOR[US]

Publicationdate: 2015-04-02 | Patent publication No.: US-20150093339-A1|Assignees: SENOMYX, INC. [US] | IPC: A23L1/22; C07D317/68; A61K8/49; C07D405/12; A61K47/24; A61K8/55; C07F9/655;A23L2/56; A61K47/22 | Oldestpriority date: 2003-08-06 |Publicationdate: 2015-04-02

Score: 8.94598 | Text size: 338101 | Find: similardocuments

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia Pa., ChemDiv of San Diego Calif., Chembridge ofSan Diego Calif.

Inhibitors Targeting the DNA-Binding Domain of Human STAT3 for Treatmentof Metastatic Cancers

Jian-Ting Zhang[US]

Score: 13.556976 | Text size: 94291 | Find: similardocuments

In-silicodock screening of 200,000 compounds from the ChemDiv librarywas performed using UCSF DOCK 6.0 program.

PYRIMIDO-PYRROLO-QUINOXALINEDIONE INHIBITORS OF CYSTIC FIBROSISTRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND USES THEREFOR

VERKMAN, Alan,S. [US];TRADTRANTIP,Lukmanee [US]

Publicationdate: 2015-04-01 | Patent publication No.: EP-2464354-B1|Assignees: The Regents of the University of California [US] | IPC:A61P1/12; A61P13/12; C07D487/14; A61K31/407; A61K31/495 | Oldest priority date: 2009-08-10 | Publication date: 2015-04-01

Score: 15.5924425 | Text size: 180341 | Find: similardocuments

screening toidentify CFTR inhbitors included approximately 105,000 synthetic smallmolecules from ChemDiv(San Diego, CA) and Asinex (San Diego, CA),and approximately 7500 purified natural compounds from ... Structure-activityanalysis was performed using analogs purchased from ChemDiv andAsinex.

External link

Method for treatment of cachexia by administering inhibitors of adiposetriglyceride lipase expression or activity

Robert Zimmerman[AT];Rudolf Zechner[AT];GüntherHaemmerle [AT]; GeraldHöfler [AT]; Suman Das [AT]; Achim Lass [AT]

Publicationdate: 2015-03-31 | Patent publication No.: US-08993509-B2|Assignees: Robert Zimmerman [AT]; Rudolf Zechner [AT]; Günther Haemmerle [AT];Gerald Höfler [AT]; Suman Das [AT]; Achim Lass [AT] | IPC: A01N61/00;A61K31/00; A01N57/00; A61K31/66; A01N43/00; A61K31/33; A01N43/58; A61K31/50;A01N43/40; A61K31/435; A01N43/44; C12Q1/44; A61K31/41; A61K31/495 | Oldest priority date: 2010-03-31 | Publication date: 2015-03-31

Score: 17.41611 | Text size: 188264 | Find: similardocuments

Furthermore,the compounds described in Example 3 can be ordered from: ChemDiv, Inc. (“ChemDiv”),6605 Nancy Ridge Drive, San Diego, Calif. 92121, USA (world wide web atchemdiv. ... In particular, compounds 2, 3, 4, 6, 7, 8, and 9 as described inExample 3 can be obtained from ChemDiv; their ChemDiv supplier'sID numbers are indicated in Example 3. Compound 5 as described in Example 3 canbe

Compositions and methods for treatment of leukemia

JolantaGrembecka [US]; Tomasz Cierpicki[US];Jay Hess [US]

Publicationdate: 2015-03-31 | Patent publication No.: US-08993552-B2|Assignees: The Regents of The University of Michigan [US]; University of VirginiaPatent Foundation [US] | IPC: A61K31/33; A61K31/519; A61K31/5513 | Oldest priority date: 2009-09-04 | Publication date: 2015-03-31

Score: 20.573181 | Text size: 71259 | Find: similardocuments

assay withFLSNMLL (μM)Vendor/Cat # IC50 in HTRF assay (μM) Compound 32[[image:EMI-C00065]] 13ChemDiv Inc. Cat # 4780-0051 7 Compound 33 [[image:EMI-C00066]]29 ChemDiv Inc. Cat # 5742-0717 28 Compound 34[[image:EMI-C00067]] 12 ChemDiv Inc. Cat # 3393-0109 NDCompound 35 [[image:EMI-C00068]] 35 ChemDiv Inc. Cat #3393-0126 ND Compound 36 [[image:EMI-C00069]] 63 ChemDiv Inc. Cat# 3170-5216 ND Compound 37 [[image:EMI-C00070]] 100 ChemDiv Inc. Cat# 3404-5359 ND Compound 38 [[image:EMI-C00071]] 115 ChemBridge Cat # 6369841 NDCompound 39 [[image:EMI-C00072]] 230 ChemDiv Inc. Cat #3170-5232 ND Compound 40 [[image:EMI-C00073]] NA ChemDiv Inc. Cat# 5531-8211 ND Compound 41 [[image:EMI-C00074]] NA ChemDiv Inc. Cat# 3770-0060 ND Compound 84 [[image:EMI-C00075]] 100 Interbioscreen STOCK2S-

NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONSAND METHODS OF TREATMENT OF CANCER

Robert Hromas[US];Andrei Leitao[BR];Tudor I. Oprea[US];Larry A. Sklar[US];Elizabeth A.Williamson [US]; Justin Wray [US]; Wei Wang [US]

Publicationdate: 2015-03-26 | Patent publication No.: US-20150087886-A1|Assignees: STC.UNM [US] | IPC: C07D215/56; C07D401/06; A61K31/475; A61N5/10; C07D401/12; A61K45/06; C07D401/10;A61K31/7048; A61K31/47; A61K31/496 | Oldestpriority date: 2010-01-26 |Publicationdate: 2015-03-26

Score: 11.918776 | Text size: 146844 | Find: similardocuments

Example 2Metnase/Intnase Inhibitor ChemDiv 5483-0023 and RelatedStudies Virtually screening for compounds that can dock within the active

Small molecule inhibitors of the α4-paxillininteraction

Mark Ginsberg[US];ChristianeKummer [US]

Publicationdate: 2015-03-24 | Patent publication No.: US-08987294-B2|Assignees: The Regents of the University of California [US] | IPC:A61K31/435; C07D221/06; A61K31/4375 | Oldest priority date: 2009-09-18 | Publication date: 2015-03-24

Score: 18.874147 | Text size: 88465 | Find: similardocuments

Thefollowing libraries were screened: Mixed Commercials 1, 2 & 4, ChemDiv 1& 2, Specplus, Maybridge 2 & 3, Peakdale2, Starr Foundation Extracts 1& 2, Philippines Plant ... 40,000 compounds was screened at a concentrationof 16 μg/ml usingthe Mixed Commercials 1, 2 & 4, ChemDiv 1 & 2,Specplus, Maybridge 2 & 3, Peakdale2, Starr Foundation Extracts 1 & 2,Philippines Plant ... Inhibitor In dose response ELISA binding assays theinhibitory effect of compound 6-B345TTQ (ChemDiv, San Diego, Calif.) wasverified for the interaction of leupaxin with α4-integrin. Interestingly, anisomer (6-B234TTQ (ChemDiv, San Diego, Calif.

Method for treating pain syndrome and other disorders

Jay Jie-Qiang Wu[US]

Score: 12.685205 | Text size: 101872 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

Antibacterial compounds

Publicationdate: 2015-03-10 | Patent publication No.: US-08975416-B2|Assignees: Summit Corporation PLC [GB] | IPC: C07D401/14; C07D403/04; C07D403/14; A61K31/4184; A61K31/4439; C07D235/18 | Oldest priority date: 2008-12-02 | Publication date: 2015-03-10

Score: 12.290053 | Text size: 142808 | Find: similardocuments

Vol. 26, No2, January 2006]. (ii) Commercial Compounds All compounds below were purchasedfromChemDiv:3,3′-(1H,1′H-5,5′-Bibenzo[d]imidazole-2,2′-diyl)dianiline(Compound 2).

METHODS AND COMPOSITIONS FOR RE-ACTIVATING EPSTEIN-BARR VIRUS ANDSCREENING COMPOUNDS THEREFOR

LIEBERMAN, Paul,M. [US];TIKHMYANOVA,Nadezhda [US]; SALVINO, Joseph,M. [US]

Publicationdate: 2015-03-05 | Patent publication No.: WO-2015031759-A1|Assignees: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY [US]; DREXEL UNIVERSITY [US] | IPC: A61K31/437;C07D471/02 | Oldestpriority date: 2013-08-31 | Publication date: 2015-03-05

Score: 18.946571 | Text size: 112170 | Find: similardocuments

Fig. 2B is ascatter plot of luminescence values for HTS campaign of the ChemDiv library.The well number is indicated on the X-axis. Fig. 2C is a scatter plot of datafrom HTS of ChemDiv screen (Fig. 2B) re-sorted according tothe fold induction of luminescence relative to DMSO. Fig. ... clinicalcollection, a 14,400 compound library from Maybridge, and a 50,000 compoundlibrary from ChemDiv. The Maybridge "Hit Finder" libraryrepresents lead-like diversity from the larger Maybridge screening collection(56,000). The ChemDiv library consists of a 30,000 compound"Discovery Chemistry" set of diverse lead-like small

Compounds and methods for treating mammalian gastrointestinal microbialinfections

Lizbeth K.Hedstrom [US]; Gregory D. Cuny[US];Deviprasad R.Gollapalli [US]; Boris Striepen[US];Suresh KumarGorla [US];MandapatiKavitha [US]

Publicationdate: 2015-03-03 | Patent publication No.: US-08969342-B2|Assignees: Brandeis University [US]; University of Georgia Research Foundation, Inc.[US]; The Brigham and Women's Hospital, Inc. [US] | IPC: A61K31/535 | Oldest priority date: 2009-03-20 |Publicationdate: 2015-03-03

Score: 10.633806 | Text size: 231650 | Find: similardocuments

Compounds D,E, F, G, and H were purchased from ChemDiv Inc. (San Diego,Calif.), Compounds A, B and C were synthesized as described previously.

Gene targets associated with amyotrophic lateral sclerosis and methods ofuse thereof

Aaron D. Gitler[US]

Publicationdate: 2015-03-03 | Patent publication No.: US-08969005-B2|Assignees: The Trustees of the University of Pennsylvania [US] |IPC: C12Q1/68; C07H21/04; C12N1/19; C12N5/10; C12N15/79 | Oldest priority date: 2010-03-28 | Publication date: 2015-03-03

Score: 12.290053 | Text size: 155241 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Compounds comprising linked heteroaryl moieties and their use as novelumami flavor modifiers, tastants and taste enhancers for comestiblecompositions

CatherineTachdjian [US]; MarketaLebl-Rinnova [US]; David Wallace[US]

Publicationdate: 2015-03-03 | Patent publication No.: US-08968708-B2|Assignees: Senomyx, Inc. [US] | IPC: A61K8/00; A61K8/18; A61Q11/00; A01N43/54; A61K31/41; A61K9/00; A23L1/226;A23L1/231; A23L1/39; A23L2/02; A23L2/56; C07D401/12; C07D405/14; A61K31/395 |Oldestpriority date: 2005-02-04 | Publication date: 2015-03-03

Score: 10.928354 | Text size: 212682 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

TRIAZOLOTHIENOPYRIMIDINE COMPOUND INHIBITORS OF UREA TRANSPORTERS ANDMETHODS OF USING INHIBITORS

Marc Anderson[US];Marc Anderson[US];Marc Anderson[US];Alan S. Verkman[US]

Publicationdate: 2015-02-26 | Patent publication No.: US-20150057274-A1|Assignees: Marc Anderson [US]; The Regents of the University of California [US] | IPC: C07D495/22 | Oldest priority date: 2012-03-27 | Publication date: 2015-02-26

Score: 14.450268 | Text size: 216255 | Find: similardocuments

For analysisof structure-activity relationships >900 commercially available analogs (ChemDiv andAsinex) were tested. ... Commercial triazolothienopyrimidine analogues werepurchased from ChemDiv (San Diego, Calif.

Pro-Neurogenic Compounds

Steven L.McKnight [US]; Joseph M. Ready[US];Andew A. Pieper[US];Jef K. DeBrabander [US]

Publicationdate: 2015-02-26 | Patent publication No.: US-20150057301-A1|Assignees: Board of Regents of the University of Texas System [US] | IPC: C07D209/08;C07D401/06; C07D413/06; C07D209/86; C07D401/12; C07D403/12; C07D405/12;C07D209/88; C07D471/04 |Oldest priority date: 2009-01-09 | Publicationdate: 2015-02-26

Score: 19.36226 | Text size: 292521 | Find: similardocuments

A HIGH-THROUGHPUT ASSAY TO IDENTIFY MOLECULES THAT MODULATE RB-E2FBINDING

RUBIN, Seth, M.[US];RUBIN, Seth, M.[US]

Score: 15.915403 | Text size: 18440 | Find: similardocuments

PreliminaryScreen Results [0030] The investigators tested -21,000 compounds from the ChemDiv libraryin the UCSC Chemical Screening Center at a concentration of 50 μΜ.

MUCOADHESIVE DEVICES FOR DELIVERY OF ACTIVE AGENTS

MURTHY, Vijay M.K. [US];STEINBERG, DavidAdam [US];PEARLMAN, Rodney[US];ROSEN, HowardBrian [US];LANGER, RobertSamuel [US];EPSTEIN-BARASH,Hila [US];BEHR, JonathanRobert [US];HARRIS, BaruchZ. [US];MITRAGOTRI,Samir Suresh [US]

Score: 12.290053 | Text size: 149530 | Find: similardocuments

fromcommercial and academic sources, for example, from Sigma-Aldrich(www.sigmaaldrich.com), ChemDiv(www.chemdiv.com), Evotec(www.evotec.com ), or ICCB (iccb .med.harvard.

ANTIBACTERIAL COMPOUNDS

WILSON, Francis,Xavier [GB];JOHNSON, Peter,David [GB];VICKERS, Richard[GB];STORER, Richard[GB];WYNNE, Graham,Michael [GB];ROACH, Alan,Geoffrey [GB]; DE MOOR, Olivier[GB];DORGAN, Colin,Richard [GB]; DAVIS, Paul,James [GB]

Score: 13.327991 | Text size: 105574 | Find: similardocuments

[M7-A7, Vol.26, No2, Jan 2006]. (ii) Commercial Compounds All compounds below werepurchased fromChemDiv: 3,3'-(1H,1'H-5,5'-Bibenzo[d]imidazole-2,2'-diyl)dianiline(Compound 2).

External link

SWEET FLAVOR MODIFIER

CatherineTACHDJIAN [US]; DonaldKARANEWSKY [US]; Sara WERNER [US]; VincentDARMOHUSODO [US]; Jeff YAMAMOTO[US]

Score: 10.633806 | Text size: 243672 | Find: similar documents

TCI Americaof Philadelphia, Pa., ChemDiv of San Diego, Calif., Chembridgeof San Diego, Calif.

Use of Stem Cells to Generate Inner Ear Cells

Huawei Li [CN]; Albert Edge [US]; Stefan Heller[US]

Score: 12.484504 | Text size: 123319 | Find: similardocuments

availablecompound libraries (suppliers include ChemBridge Corp (San Diego, Calif.)and ChemDiv (San Diego, CA)).

METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCLE WASTING, MUSCLEWEAKNESS, AND/OR CACHEXIA

TWEARDY, David,J. [US];KASEMBELI,Moses, M. [US]; XU, Marvin, X.[CN];ECKOLS, Thomas,Kristian [US]

Score: 14.450268 | Text size: 243802 | Find: similardocuments

Commercialchemical databases (Chembridge, Asinex, ChemDiv, Enamine,Keyorganics and Life Chemicals) were chosen as sources of compounds for screeningin ... The databases searched included ChemBridge, LifeChemicals,Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for atotal of 2.47 million compounds.

METHODS AND COMPOSITIONS FOR PREVENTION OF ALLERGIC REACTION

TWEARDY, David,J. [US];KASEMBELI,Moses, M. [US]; XU, Marvin, X.[CN];MILNER, Josh[US];BOCCHINI, ClaireE. [US]

Publicationdate: 2015-01-22 | Patent publication No.: WO-2015010106-A1|Assignees: BAYLOR COLLEGE OF MEDICINE [US]; THE UNITED STATES OF AMERICA, ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US] | IPC: A61K31/18;A61K31/05 | Oldestpriority date: 2013-07-18 | Publication date: 2015-01-22

Score: 15.906768 | Text size: 164720 | Find: similardocuments

Commercialchemical databases (Chembridge, Asinex, ChemDiv, Enamine,Keyorganics and Life Chemicals) were chosen as sources of compounds for screeningin ... The databases searched included ChemBridge, LifeChemicals,Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for atotal of 2.47 million compounds.

METHODS AND COMPOSITIONS FOR TREATMENT OF FIBROSIS

TWEARDY, David,J. [US];KASEMBELI,Moses, M. [US]; XU, Marvin, X.[CN];AGARWAL,Sandeep, K. [US]; PEDROZA, Mesias[US]

Score: 15.906768 | Text size: 161456 | Find: similardocuments

METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCLE WASTING, MUSCLEWEAKNESS, AND/OR CACHEXIA

David J. Tweardy[US];Moses M.Kasembeli [US]; Marvin X. Xu[CN];Thomas KristianEckols [US]

Publicationdate: 2015-01-22 | Patent publication No.: US-20150024032-A1|Assignees: BAYLOR COLLEGE OF MEDICINE [US] | IPC:C07D333/34;A61K31/4406; A61K31/415; A61K31/381; A61K31/357; C07C317/28; C07D215/36;C07D213/71; C07D231/18; C07D319/18; C07C317/34; A61K31/47; A61K31/145 | Oldest priority date: 2013-07-18 | Publication date: 2015-01-22

Score: 14.190399 | Text size: 270404 | Find: similardocuments

Commercialchemical databases (Chembridge, Asinex, ChemDiv, Enamine,Keyorganics and Life Chemicals) were chosen as sources of compounds for screeningin ... The databases searched included ChemBridge, LifeChemicals,Enamine, ChemDiv, Asinex, AcbBlocks, KeyOrganics and PubChem for atotal of 2.47 million compounds.

MODULATORS OF TOUSLED KINASE IN CELLULAR PROCESSES

ArrigoDeBenedetti [US]; Gulshan Sunavala[US]

Publicationdate: 2015-01-15 | Patent publication No.: US-20150018294-A1|Assignees: Arrigo DE BENEDETTI [US]; Gulshan SUNAVALA [US] | IPC: A61K31/5415;A61N5/10; A61K31/7064; A61K31/553; A61K31/65; A61K31/22 | Oldest priority date: 2012-02-07 | Publication date: 2015-01-15

Score: 11.239684 | Text size: 184553 | Find: similardocuments

the FWCC)screened the Prestwick library, two other proprietary libraries, and a subsetof the ChemDiv library ( ̃6000 compounds).

COMPOSITIONS AND METHODS FOR INHIBITING NOROVIRUS INFECTION

Xi Jiang [US]; Ming Tan [US]; Xufu Zhang [CN]

Publicationdate: 2015-01-15 | Patent publication No.: US-20150018326-A1|Assignees: CHILDREN'S HOSPITAL MEDICAL CENTER [US] |IPC: C07J41/00; C07J9/00; C07J3/00; C07J7/00 | Oldest priority date: 2013-07-12 | Publication date: 2015-01-15

Score: 13.793969 | Text size: 82826 | Find: similardocuments

Molport(http://www.molport.com) supplied by Maybridg, TimTec, ChemBridge, Pharmeks,Specs, Otava,ChemDiv, InterBioScreen Ltd, Vitas-M Laboratory, PrincetonBiomolecular Research and Enamine Ltd.

POSITIVE ALLOSTERIC MODULATORS FOR MELANOCORTIN RECEPTORS

Roger D. Cone[US];Julien A. Sebag[US];Jacques Pantel[FR];Savannah Y.Williams [US]; David C. Weaver[US];Gary A.Sulikowski [US]; Craig W.Lindsley [US]; Padma S.Portonova [US]; Chao Zhang [US]

Publicationdate: 2015-01-15 | Patent publication No.: US-20150018371-A1|Assignees: Vanderbilt University [US] | IPC: A61K31/519; A61K31/4192; A61K31/343; A61K31/427; A61K31/437; A61K31/381;A61K31/495; A61K31/4355; A61K31/506; A61K31/4709; A61K31/4152; A61K31/4162;A61K31/426; A61K31/517; A61K31/166; A61K31/47; A61K31/436; A61K31/216;G01N33/50; A61K31/4045 | Oldestpriority date:2012-03-06 | Publication date: 2015-01-15

Score: 14.293713 | Text size: 59054 | Find: similardocuments

from theVanderbilt Small Molecule Library, which includes over 160,000 compoundsobtained from ChemDivand ChemBridge. The present invention isillustrated by the following examples.

COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATEACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14

TRAN, Nhan [US]; MEURICE,Nathalie [US]; DHRUV, Harshil[US];YIN, Hongwei[US];TRAN, Nhan [US]; MEURICE,Nathalie [US]; DHRUV, Harshil[US];YIN, Hongwei[US]

Score: 18.078405 | Text size: 205795 | Find: similardocuments

implementedto identify virtual hits from a vendor compound library of peptidomimeticmolecules (ChemDiv, 13,637 compounds). ... The peptidomimetic setof ChemDiv (version of May 2011; 13,137 compounds) wasprepared using LigPrep version 2.5 in Schrodinger v2011 ... The peptidomimeticset of ChemDiv (13,137 compounds, v05.2011) was selected forthis study and pre-processed as described in methods. ... As shown in Figure10A, 4 compounds from the supplier ChemDiv with compoundidentifiers G873-0032, F151-0435, D715-0890, and J004- 1091 showed an average... These core substructures served as query to perform a substructure searchin the ChemDiv online catalogue.

FN14 ANTAGONISTS AND THERAPEUTIC USES THEREOF

Nhan Tran [US]; Nathalie Meurice[US];Harshil Dhruv[US]

Publicationdate: 2015-01-15 | Patent publication No.: US-20150017263-A1|Assignees: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE [US] | IPC: A61K31/542;A61K31/541; A61K45/06; A61K31/53; A61K31/47 | Oldest priority date: 2013-07-09 | Publication date:2015-01-15

Score: 17.914232 | Text size: 208322 | Find: similardocuments

implementedto identify virtual hits from a vendor compound library of peptidomimeticmolecules (ChemDiv, 13,637 compounds). ... The peptidomimetic setof ChemDiv (version of May 2011; 13,137 compounds) wasprepared using LigPrep version 2.5 in Schrodinger v2011 ... The peptidomimeticset of ChemDiv (13,137 compounds, v05.2011) was selected forthis study and pre-processed as described in methods. ... As shown in FIG. 10A,4 compounds from the supplier ChemDiv with compoundidentifiers G873-0032, F151-0435, D715-0890, and J004-1091 showed an average... These core substructures served as query to perform a substructure searchin the ChemDiv online catalogue.

SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)

LIST, Alan F.[US];WEI, Sheng [US]

Publicationdate: 2015-01-08 | Patent publication No.: WO-2015003149-A2|Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: A01N25/00;A61K39/00; C12P21/04 | Oldestpriority date: 2013-07-05 | Publication date: 2015-01-08

Score: 11.569273 | Text size: 159579 | Find: similardocuments

ChemBridgeCorporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA,www.chembridge.com);ChemDiv (6605 Nancy Ridge Drive, San Diego, CA92121, USA); Life Chemicals (1103 Orange Center Road,

TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

Steven AlbertEverett [US]; Saraj Ulhaq [GB]

Publicationdate: 2015-01-08 | Patent publication No.: US-20150011512-A1|Assignees: University Court of the University of Dundee [GB] | IPC: A61K47/48;A61K31/37; A61K31/4184; A61K31/343; A61K31/428; A61K31/52; A61K31/513; A61K31/665;A61K31/381 | Oldestpriority date: 2009-05-01 | Publication date: 2015-01-08

Score: 15.970954 | Text size: 225141 | Find: similardocuments

Benzodiazepine compounds with anti-flavivirus activity

Andrea Cuconati[US];Jinhong Chang[US];Timothy M. Block[US];Ju-Tao Guo [US]

Publicationdate: 2015-01-08 | Patent publication No.: US-20150011537-A1|Assignees: Baruch S. Blumberg Institute [US]; Philadelphia Health & EducationCorporation d/b/a Drexel University College of Medicine [US] | IPC: C12Q1/02;A61K31/5513 | Oldestpriority date: 2012-02-24 | Publication date: 2015-01-08

Score: 15.639392 | Text size: 20470 | Find: similardocuments

EXAMPLE 1High Throughput Screening Compound library: 26,900 compounds from a library (ChemDivInc.) were tested at a single concentration of 10 micromolar.

METHODS, SYSTEMS, AND DEVICES FOR AN INVERTEBRATE MODEL OF TRAUMATICBRAIN INJURY

Barry S.Ganetzky [US]; David A.Wassarman [US]

Publicationdate: 2014-12-25 | Patent publication No.: US-20140377183-A1|Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION [US] | IPC: A61K49/00;A61B5/00; A61D3/00; G01N33/50 | Oldestpriority date: 2013-06-25 | Publication date: 2014-12-25

Score: 14.293713 | Text size: 77386 | Find: similardocuments

DiscoverySystems, Inc. (Gaylordsville, Conn.); ChemBridge Corporation (San Diego,Calif.); and ChemDiv Inc.(San Diego, Calif.

SMALL MOLECULE ACTIVATORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS ANDMETHODS OF USE

Alan S. Verkman[US];Wan Namkung [US]

Score: 15.5924425 | Text size: 140692 | Find: similardocuments

METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS

Jay Jie-Qiang Wu[US]

Score: 12.685205 | Text size: 101385 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OR ELIMINATING BITTERTASTE

Francis XavierBrennan [US]; William P. Jones[US];Jane V. Leland[US];David Hayashi[US]

Score: 11.239684 | Text size: 188315 | Find: similardocuments

may beobtained from commercial vendors for synthetic and natural compounds, such asVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

METHODS AND COMPOSITIONS TO TREAT CANCER

WHITSETT,Jeffrey [US]; MAEDA, Yutaka[US]

Score: 14.039395 | Text size: 67976 | Find: similardocuments

3-[2-(4-fluorobenzyl)imidazo[2,l-beta][l,3]thiazol-6-yl]-2H- chromen-2-one (iMDK) purchased from ChemDiv(SanDiego, CA) was dissolved in DMSO.

METHODS FOR MATURING CARDIOMYOCYTES AND USES THEREOF

RUOHOLA-BAKER,Hannele [US]; KUPPUSAMY,Kavitha [US]; SPERBER, Henrik[US]

Score: 11.918776 | Text size: 194728 | Find: similardocuments

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive ChemistryLtd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.

COMPOSITIONS AND METHODS TO PROTECTCELLS BY BLOCKING ENTRY OF PATHOGEN PROTEINS

Brett Tyler [US]; Shiv Kale [US]; VincenzoAntignani [US]

Score: 11.569273 | Text size: 183050 | Find: similardocuments

severalsources including established chemical vendors like Asinex, Analyticon, Biomol,Bionet, ChemDiv, Enamine, Maybridge, Spectrum, TimTec as well as arange of diversity oriented synthesis compounds

Sweet flavor modifier

CatherineTachdjian [US]; DonaldKaranewsky [US]; Sara Werner [US]; VincentDarmohusodo [US]; Jeff Yamamoto[US]

Score: 10.928354 | Text size: 242770 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America of Philadelphia,Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego,Calif.

Methods for treating Parkinson's disease using pro-neurogenic compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Publicationdate: 2014-11-04 | Patent publication No.: US-08877797-B2|Assignees: Board of Regents of The University of Texas System [US] | IPC: A61K31/4439;C07D209/86; C07D401/12; C07D405/12; C07D209/08; A61K31/403; C07D495/04;C07D209/88; C07D413/06; C07F5/02; C07D401/06; C07D209/56; C07D487/04;C07D403/12; C07D471/04; C07D403/06 | Oldestpriority date: 2009-01-09 | Publication date: 2014-11-04

Score: 17.997265 | Text size: 720397 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol [[image:EMI-C00138]]This compound can be purchased from ChemDiv, Inc.Example 611-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00139]] This compound can be purchased from ChemDiv, Inc. Example62 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00140]] This compound can be purchased from ChemDiv, Inc. Example63 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00141]] This compound can be purchased from ChemDiv, Inc. Example

INHIBITORS OF PHOSPODIESTERASES 11 (PDE11) AND METHODS OF USE TO ELEVATECORTISOL PRODUCTION

Charles StuartHoffman [US]; Ozge Ceyhan [US]

Score: 14.592621 | Text size: 341537 | Find: similardocuments

ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME

Dan Theodorescu[US];MichaelFitzpatrick Wempe [US]; David Ross [US]; Samy Meroueh[US];Martin A.Schwartz [US]; Phillip Reigan[US]

Publicationdate: 2014-10-23 | Patent publication No.: US-20140315894-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US] | IPC: C07D491/052;A61K45/06; A61K31/351; A61K31/505; A61K31/437; A61K31/4162; A61K31/5513 | Oldest priority date: 2011-12-21 | Publication date: 2014-10-23

Score: 12.484504 | Text size: 131314 | Find: similardocuments

To do so,RalA-GDP was set up for docking, and the ChemDiv library(v2006.

Compounds, compositions, and methods for reducing or eliminating bittertaste

Kambiz Shekdar[US];Daniel Lavery[US];Joseph Gunnet[US];Jessica Langer[US];Jane V. Leland[US];David Hayashi[US];Peter H. Brown[US];Louise Slade[US];William P. Jones[US]

Publicationdate: 2014-10-21 | Patent publication No.: US-08865779-B2|Assignees: Chromocell Corporation [US]; Kraft Foods Group Brands LLC [US] | IPC: A61K47/00; C07C49/00|Oldestpriority date: 2010-04-15 | Publication date: 2014-10-21

Score: 8.557886 | Text size: 402725 | Find: similardocuments

wereobtained from commercial vendors for synthetic and natural compounds, includingVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

Method for treating pain syndrome and other disorders

Jay Jie-Qiang Wu[US]

Publicationdate: 2014-10-21 | Patent publication No.: US-08865727-B2|Assignees: VM Therapeutics LLC [US] | IPC: A61K31/519; A61K31/4184; C07D401/06; C07D513/04; C07D471/04; A61K31/498 | Oldest priority date: 2008-02-29 | Publication date: 2014-10-21

Score: 12.892465 | Text size: 96311 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

Materials and method for inhibiting replication protein A and usesthereof

John J. Turchi[US];Sarah Shuck [US]

Score: 18.390413 | Text size: 59220 | Find: similardocuments

TRANSIENT UP-REGULATION OF MYC IN B-CELL LYMPHOMAS

THOMAS-TIKHONENKO,Andrei [US];SOTILLO-PINEIRO,Elena [US]

Score: 15.261294 | Text size: 27966 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

COMPOUNDS FOR MODULATING TLR2

Robert W.Finberg [US]; Evelyn A.Kurt-Jones [US]; Shenghua Zhou[US]

Publicationdate: 2014-10-02 | Patent publication No.: US-20140296219-A1|Assignees: UNIVERSITY OF MASSACHUSETTS [US] | IPC:A61K31/454;A61K31/423; A61K31/4535; A61K31/4725; A61K31/4433; A61K31/443; A61K31/506;A61K31/4745; A61K31/551; A61K31/429; A61K31/4439; A61K31/496 | Oldest priority date: 2009-11-18 | Publication date: 2014-10-02

Score: 15.290299 | Text size: 153148 | Find: similardocuments

DIMETHYLARGININE DIMETHYLAMINOHYDROLASE INHIBITORS AND METHODS OF USETHEREOF

COOKE, John P.[US];GHEBREMARIAM,Yohannes T. [US]

Score: 16.167183 | Text size: 337095 | Find: similardocuments

Center(HTBC) contains over 130,000 small molecules selected from diverse sourcesincluding Sigma,ChemDiv, MicroSource, ChemBridge, the NIH clinicalcollection (NIH CC), National Cancer Institute (NCI), ... compounds such asphenylmercuric acetate (IC50 < 0.78 μΜ) and quinone-type compoundssuch as ChemDiv2548-0707 (IC50=5.5 μΜ) and 2548-0703 (IC50=9.0 μΜ). ...showing inhibition of human DDAH-1 activity by selected small molecules usingthe CPM assay: A) ChemDiv Compound 2548-0707; B) ChemDiv Compound2548-0703; C) 4-MMP; and D) SCH-202676.

STAT3 Inhibitors

David J. Tweardy[US];Xuejun Xu [US]; Moses M.Kasembeli [US]

Publicationdate: 2014-10-02 | Patent publication No.: US-20140296270-A1|Assignees: Baylor College of Medicine [US] | IPC:A61K31/515;A61K31/427; C07D417/06; A61K31/194; A61K45/06; A61K31/192; C07C65/17;A61K31/37; C07D311/74; C07D405/06; A61K31/357; C07C311/21 | Oldest priority date: 2008-06-04 | Publication date: 2014-10-02

Score: 14.719831 | Text size: 223807 | Find: similar documents

TUNABLE CONTROL OF PROTEIN DEGRADATION IN SYNTHETIC AND ENDOGENOUSBACTERIAL SYSTEMS

CAMERON,Douglas, Ewen [US]; COLLINS, James,J. [US]

Score: 11.239684 | Text size: 264313 | Find: similar documents

for example,from Enzo Life SciencesTM, Aurora Fine ChemicalsTM, Exclusive ChemistryLtd.TM, ChemDiv, ChemBridgeTM, TimTec Inc.TM, AsisChemTM, andPrinceton Biomolecular ResearchTM, among others.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING SWEET TASTE

LUO, Robert,Zhiyong [US]; CURRAN, Kevin,Joseph [US];HAYDEN, Stuart[US];YANG, Gengcheng[US];JIANG, Deshou[US];KRAL, Vincent[US]

Score: 8.557886 | Text size: 323987 | Find: similardocuments

may beobtained from commercial vendors for synthetic and natural compounds, such asVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

OSTEOCALCIN AS A TREATMENT FOR COGNITIVE DISORDERS

KARSENTY, Gerard[US];OURY, Franck[US]

Publicationdate: 2014-09-25 | Patent publication No.: WO-2014152497-A2|Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US] | IPC: A01N33/00;A61K38/00 | Oldestpriority date: 2013-03-15 | Publication date: 2014-09-25

Score: 10.089907 | Text size: 309669 | Find: similardocuments

MaybridgeHitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds);ChemDiv Combilaband International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds);Mixed

CELLULAR DISCOVERY PLATFORM FOR NEURODEGENERATIVE DISEASES

LINDQUIST, SusanL. [US];KHURANA, Vikram[US];CHUNG, Chee-yeun[US]

Score: 7.032474 | Text size: 621639 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow, Russia),ChemStar (Moscow, Russia), Exclusive

SUBUNIT SELECTIVE NMDA RECEPTOR POTENTIATORS FOR THE TREATMENT OFNEUROLOGICAL CONDITIONS

Stephen F.Traynelis [US]; Dennis C. Liotta[US];Rose M.Santangelo [US]; Ethel C. Garnier[US]

Publicationdate: 2014-09-18 | Patent publication No.: US-20140275529-A1|Assignees: Stephen F. Traynelis [US]; Dennis C. Liotta [US]; Rose M. Santangelo [US];Ethel C. Garnier [US] | IPC: C07D217/16; C07D491/056; C07D405/06; C07D413/06; C07D401/06; C07D409/06 | Oldest priority date: 2009-01-28 | Publication date: 2014-09-18

Score: 16.882145 | Text size: 148812 | Find: similardocuments

METHODS OF TREATING MUSCULAR DYSTROPHY

BURKIN, Dean[US];WUEBBLES, Ryan[US];BURKIN, Dean[US];WUEBBLES, Ryan[US]

Publicationdate: 2014-09-18 | Patent publication No.: WO-2014144606-A2|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THEUNIVERSITY OF NEVADA, RENO [US] | IPC: A61K31/404; C07D209/04 | Oldestpriority date: 2013-03-15 | Publication date: 2014-09-18

Score: 11.239684 | Text size: 287657 | Find: similardocuments

et al.,2006). 2) DIVERSet library (Chembridge Corp., San Diego, CA) and compounds fromthe ChemDiv library. 3) LOPAC library (Sigma-RPI) consists of1280 pharmaceutically active compounds.

BENZIMIDAZOLE DERIVATIVES AND USES THEREOF

LINDQUIST,Susan, L. [US]; BUCHWALD,Stephen, L. [US]; TARDIFF, Daniel[US];JUI, Nathan [US]

Publicationdate: 2014-09-18 | Patent publication No.: WO-2014145887-A1|Assignees: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH [US]; MASSACHUSETTS INSTITUTEOF TECHNOLOGY [US] | IPC: A01N37/18; A01N43/40; A01N43/50 | Oldestpriority date: 2013-03-15 | Publication date: 2014-09-18

Score: 10.354719 | Text size: 277781 | Find: similardocuments

of compoundsof Formula (I). [00219] The original screen hit compound, ABI, was purchasedfrom ChemDiv(K783- 0286). Subsequent synthesis was performedaccording to the following strategy.

QUINAZOLINONE ANTIBIOTICS

CHANG, Mayland[US];MOBASHERY,Shahriar [US]; BOULEY, Renee[US]

Publicationdate: 2014-09-12 | Patent publication No.: WO-2014138302-A1|Assignees: UNIVERSITY OF NOTRE DAME DU LAC [US] | IPC:C07D239/91; C07D401/02; C07D403/02; C07D407/06; C07D413/02; A61K31/517;A61K31/519; A61P31/04 | Oldestpriority date: 2013-03-05 |Publicationdate: 2014-09-12

Score: 15.5924425 | Text size: 140045 | Find: similardocuments

USE OF SMALL MOLECULE INHIBITORSTARGETING EYA TYROSINE PHOSPHATASE

HEGDE, Rashmi[US]

Score: 11.239684 | Text size: 186206 | Find: similardocuments

L129305) andcompound lb from ChemDiv (cat. no. 3039-0682).

Compounds comprising linked heteroaryl moieties and their use as novelumami flavor modifiers, tastants and taste enhancers for comestiblecompositions

CatherineTachdjian [US]; MarketaLebl-Rinnova [US]; David Wallace[US]

Publicationdate: 2014-07-22 | Patent publication No.: US-08784782-B2|Assignees: Senomyx, Inc. [US] | IPC: A61K8/00; A61K8/18; A61Q11/00; A01N43/64; A61K31/41; A61K9/00; A61K31/395 | Oldest priority date: 2005-02-04 | Publication date: 2014-07-22

Score: 10.928354 | Text size: 208599 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

Stat3 inhibitors

David J. Tweardy[US];Xuejun Xu [US]; Moses M.Kasembeli [US]

Publicationdate: 2014-07-15 | Patent publication No.: US-08779001-B2|Assignees: The United States of America National Institute of Health (NIH) [US]; TheUnited States of America Dept. of Health and Human Services (DHHS) [US] | IPC: A61K31/18 | Oldest priority date:2008-06-04 | Publication date: 2014-07-15

Score: 14.719831 | Text size: 226903 | Find: similardocuments

VITAMIN D RECEPTOR-COREGULATOR INHIBITORS

Alexander E.Arnold [US];Preetpal SinghSidhu [US];PremchendarNandhikonda [US]; Rakesh K. Singh[US]

Publicationdate: 2014-07-10 | Patent publication No.: US-20140194472-A1|Assignees: WOMEN AND INFANTS' HOSPITAL OF RHODE ISLAND [US]; UWM RESEARCH FOUNDATION,INC. [US] | IPC: C07D209/14; C07D209/10; C07D401/12 | Oldest priority date: 2011-08-26 |Publicationdate: 2014-07-10

Score: 10.633806 | Text size: 187291 | Find: similardocuments

The smallmolecule collection consisted of 275,000 unique compounds from commercialsources (ChemDiv, ChemBridge, and Life Chemicals).

Inhibitors of proline racemase enzymes for the treatment of Trypanosomaspp infections

MINOPRIO, Paola[FR];BERNEMAN, Armand[FR];BLONDEL, Arnaud[FR]

Score: 19.412693 | Text size: 88576 | Find: similardocuments

the virtualscreening of several thousand molecules out of two accessible chemicallibraries: ChemDiv, Inc(San Diego, California, USA) andChimiothèque Nationale (CNRS, France). ... for the virtual screening of31000 compounds of the Chimiothèque Nationale and 63000 compoundsof ChemDiv chemical libraries (www.chemdiv.com; www.chimiotheque-nationale.enscm.fr).... perform the virtual screening of about 700.000 molecules from twoaccessible chemical libraries: ChemDiv, Inc (San Diego,California, USA) and Chimiothèque Nationale (CN, CNRS, France). ...virtual screening of 31000 compounds of the Chimiothèque Nationale (CN)and 630000 compounds of ChemDiv chemical libraries.

External link

Anti-angiogenic compounds

Danzhi Huang[CH];Peter Kolb [AT]; Karine Lafleur[CH];Cristina Nevado[CH];Amedeo Caflisch[CH]

Score: 13.327991 | Text size: 103269 | Find: similar documents

example,three libraries were combined for a total of 728,202 compounds: the NCIdatabase, the ChemDivlibrary (Moscow, Russia) and the synthetic andnatural compound library of InterBioScreen (Moscow,

Rab7 GTPase inhibitors and related methods of treatment

Angela Wandinger-Ness[US];Larry Sklar [US]; Jacob Agola [US]; Zurab Surviladze[US];JeffreyAubé [US]; Jennifer Golden[US];Chad E.Schroeder [US]; Denise S.Simpson [US]

Score: 16.189404 | Text size: 229335 | Find: similardocuments

acid withcompound identification number (CID) 1067700 was from ChemDiv. ...acid was purchased fromChemdiv Inc. (CAS 314042-01-8) and purifiedby mass-directed reverse-phase chromatography to yield a white solid ... acidwith compound identification number (CID) 1067700 was from ChemDiv andfrom University of Kansas Specialized Chemistry Center, which also suppliedanalogs to

SirT INHIBITORS THAT BIND TO NAD

Andrew D. Napper[US];Peter DiStefano[US];Rory Curtis [US]; Jeffrey Hixon[US];Thomas E.McDonagh [US]; L. Julie Huber[US];Jonathan M.Solomon [US]; Russel J. Thomas[GB];Jean-francoisPons [GB]

Publicationdate: 2014-06-12 | Patent publication No.: US-20140163029-A1|Assignees: ELIXIR PHARMACEUTICALS, INC. [US] | IPC:C07D471/04; C07D209/94; C07D209/18; C07D209/88 | Oldest priority date: 2003-09-12 | Publication date: 2014-06-12

Score: 11.569273 | Text size: 176977 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, SanDiego, Calif.

RNF41 AS A BIOMARKER PREDICTING RESPONSE TO LENALIDOMIDE IN NON-DEL(5Q)MDS

LIST, Alan [US]

Publicationdate: 2014-06-12 | Patent publication No.: WO-2014089279-A1|Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US] | IPC: G01N33/68;G01N33/53; G01N33/48 | Oldestpriority date: 2012-12-05 | Publication date: 2014-06-12

Score: 14.831028 | Text size: 45617 | Find: similardocuments

ChemBridgeCorporation (16981 Via Tazon, Suite G, San Diego, CA, 92127, USA,www.chembridge.com);ChemDiv (6605 Nancy Ridge Drive, San Diego, CA92121, USA); Life Chemicals (1103 Orange Center Road,

SUBSTITUTED ISOXAZOLE AMIDE COMPOUNDS AS INHIBITORS OF STEAROYL-COADESATURASE 1 (SCD1)

ERICKSON, Shawn,David [US];GILLESPIE, Paul[US];MERTZ, Eric [US]

Publicationdate: 2014-06-12 | Patent publication No.: WO-2014086704-A1|Assignees: F. HOFFMANN-LA ROCHE AG [CH]; HOFFMANN-LA ROCHE INC. [US] | IPC: C07D413/04;C07D413/10; C07D413/12; C07D261/18; A61K31/42; A61K31/4439; A61P35/00 | Oldest priority date:2012-12-03 | Publication date: 2014-06-12

Score: 16.068731 | Text size: 138919 | Find: similardocuments

acid ethylester, the compound of formula 5, which is commercially available from vendorssuch as ChemDiv, Inc., 6605 Nancy Ridge Dr, San Diego, CA, 92121,USA. ... acid ethyl ester (available from ChemDiv Inc., 6605 NancyRidge Dr, San Diego, CA, 92121, USA; 15 g, 60.

Phenylalanine derivatives and their use as non-peptide GLP-1 receptormodulators

Jiayu Liao [US]; Yufeng Hong [US]; Yong Wang [US]; Thomas W. VonGeldern [US]; Kanyin E. Zhang[US]

Publicationdate: 2014-06-10 | Patent publication No.: US-08748412-B2|Assignees: Argusina Bioscience Inc. [KY] | IPC: A61K31/635; A61K31/341; A61K31/27; A61K31/4245; A61K31/4439; A61K31/506;A61K31/454; A61K31/5377; A61K31/551; C07C271/28; C07D271/06; C07D413/12;C07D413/14; C07D307/68 | Oldestpriority date: 2011-02-02 | Publication date: 2014-06-10

Score: 10.089907 | Text size: 308751 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

Methods of treating post-traumatic stress disorder using pro-neurogeniccompounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Score: 18.939768 | Text size: 456218 | Find: similardocuments

from ChemDiv,Inc. Example 59 1-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol[[image:EMI-C00130]] Purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00131]] Purchased from ChemDiv, Inc. Example 611-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00132]] Purchased fromChemDiv, Inc. Example 621-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00133]] Purchased from ChemDiv, Inc. Example 631-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00134]] Purchased from ChemDiv, Inc. Example

STRUCTURE OF THE C-TERMINAL REGION OF THE INSULIN RECEPTOR a-CHAIN AND OFTHE INSULIN-LIKE GROWTH FACTOR RECEPTOR a-CHAIN

Michael C.Lawrence [AU]; Brian J. Smith[AU];John G.T.Menting [AU]; Colin W. Ward[AU]

Publicationdate: 2014-06-05 | Patent publication No.: US-20140154817-A1|Assignees: Michael C. Lawrence [AU]; Brian J. Smith [AU]; John G.T. Menting [AU];Colin W. Ward [AU] | IPC: G06F19/12; G01N33/566 | Oldestpriority date: 2009-04-22 | Publication date: 2014-06-05

Score: 11.918776 | Text size: 191725 | Find: similardocuments

from, forexample, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest,Hungary) and ChemDiv(San Diego, Calif.), Specs (Delft, TheNetherlands).

Scyllo-Inositol Derivatives and Their Use in the Treatment of DiseasesCharacterized by Abnormal Protein Folding or Aggregation of Amyloid Formation,Deposition, Accumulation for Persistence

Antonio CRUZ[CA];Linda KURDYDYK[CA]

Score: 19.0931 | Text size: 214564 | Find: similardocuments

C 55.37% H7.75% O 36.88% IRL 2 [[image:EMI-C00186]] C 58.53% H 4.91% N 17.06% O19.49% ChemDiv 0 [[image:EMI-C00187]] C 67.82% H 4.38% O27.80% ChemDiv 0 [[image:EMI-C00188]] C 53.83% H 7.74% N17.94% O 20.49% ChemDiv 0 [[image:EMI-C00189]] C 48.00% H5.37% N 9.33% O 37.30% ChemDiv 0 [[image:EMI-C00190]] C 45.22%H 4.74% Cl 11.12% N 8.79% O 30.12% ChemDiv 0[[image:EMI-C00191]] C 49.75% H 5.57% Cl 12.24% N 4.83% O 27.61% ChemDiv 0[[image:EMI-C00192]] C 49.68% H 5.77% N 8.91% O 35.63% ChemDiv 0[[image:EMI-C00193]] C 49.75% H 5.57% Cl 12.24% N 4.83% O 27.61% ChemDiv 0[[image:EMI-C00194]] C 43.13% H 4.83% Br 23.91% N 4.19% O 23.94% ChemDiv 0[[image:EMI-C00195]] C 56.33% H 7.09% N 6.57% O 30.01% ChemDiv 0[[image:EMI-C00196]] C 66.93% H 11.70% N 6.50% O 14.

Pharmacophores for Amyloid Fibers Involved in Alzheimer's Disease

David S.Eisenberg [US]; Lin Jiang [US]; Meytal Landau[IL];Cong Liu [US]

Publicationdate: 2014-06-05 | Patent publication No.: US-20140154180-A1|Assignees: The Regents of the University of California [US] |IPC: G06F19/16; A61K31/12; G01N33/68; A61K31/473; A61K31/704; A61K31/655;A61K31/536 | Oldestpriority date: 2011-07-14 |Publicationdate: 2014-06-05

Score: 17.809187 | Text size: 246329 | Find: similardocuments

± 7.8ZINC28616347 BAF17 C23H25N5O2 404 Sigma-Aldrich 5.5 ± 3.4 ZINC00579168 BAF18C24H16O2 336ChemDiv 5.6 ± 2.2 ZINC02168932 BAF19 C18H14N2O6354 ChemDiv 3.1 ± 4.1 ZINC01507439 BAF20 C25H19N5OS 438 ChemDiv 7.6± 4.4 ZINC15859747 BAF21 C19H14Br2O 418 ChemDiv 6.1 ± 3.2ZINC38206526 BAF22 C21H16N2O3S2 408 Life Chemicals 2.8 ± 4.7 ZINC04496365 BAF23

Methods for treating amyotrophic lateral sclerosis using pro-neurogeniccompounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Score: 17.997265 | Text size: 718476 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 591-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol This compoundcan be purchased from ChemDiv, Inc. [[image:EMI-C00137]]Example 60 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00138]] This compound can be purchased from ChemDiv, Inc. Example61 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00139]] This compound can be purchased from ChemDiv, Inc. Example62 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol Thiscompound can be purchased from ChemDiv, Inc. [[image:EMI-C00140]]Example

Compositions and methods for treating alcohol use disorders, pain andother diseases

Jay Jie-Qiang Wu[US]

Publicationdate: 2014-05-20 | Patent publication No.: US-08729081-B2|Assignees: VM Discovery Inc. [US] | IPC: C07D413/12; C07D498/04; C07D471/04; A61K31/538; A61K31/498; A61K31/4375 | Oldest priority date: 2008-10-10 | Publication date: 2014-05-20

Score: 10.928354 | Text size: 250456 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.) or can be synthesized.

Paramyxovirus family inhibitors and methods of use thereof

Richard K.Plemper [US]; James P. Snyder[US];Aiming Sun [US]

Score: 12.892465 | Text size: 117292 | Find: similardocuments

The compoundlibrary used is a diversity set from ChemDiv (San Diego,Calif.). Example 3 Chemical Synthesis of Compound 16677.

ANTAGONISTS OF GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATEDTHERETO

JONES, Robert M.[US];SCHWARTZ, ThueWalter [DK];KRISTENSEN, LineVildbrad [DK]; MADSEN, TorbenAndreas Nygaard [DK]

Publicationdate: 2014-05-15 | Patent publication No.: WO-2014074700-A1|Assignees: ARENA PHARMACEUTICALS, INC. [US]; THE UNIVERSITY OF COPENHAGEN [DK] | IPC: C07D401/14;A61K31/506; A61P3/00; A61P35/00 | Oldestpriority date: 2012-11-08 | Publication date: 2014-05-15

Score: 11.569273 | Text size: 189485 | Find: similardocuments

6), as usedherein, refers to the following chemical structure: [[image:imgf000023_0001]] (ChemDiv,San Diego, USA).

MEANS AND METHODS FOR IDENTIFYING RIBOSOME ASSOCIATED RNA MOLECULES

NAIRZ, Knud [CH]; GERBER,André [CH]

Score: 16.644737 | Text size: 216162 | Find: similardocuments

LIPID CONTAINING FORMULATIONS

MuthiahManoharan [US]; KallanthottathilG. Rajeev [US]; Akin Akinc [US]; Narayanannair K.Jayaprakash [US]; MuthusamyJayaraman [US]; Martin Maier[US]

Publicationdate: 2014-05-01 | Patent publication No.: US-20140121393-A1|Assignees: Tekmira Pharmaceuticals Corporation [CA] | IPC:C07C219/06; C07C209/78; C07C323/25; C07C271/10; C07C233/36 | Oldest priority date: 2006-10-03 | Publication date: 2014-05-01

Score: 10.354719 | Text size: 279008 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, SanDiego, Calif.

Compounds that inhibit human DNA ligases and methods of treating cancer

Alan E.Tomkinson [US]; Xi Chen [US]; BarbaraDziegielewska [US]; Alexander D.Mackerell [US]; Shijun Zhong[MD];Gerald M. Wilson[US]

Publicationdate: 2014-04-24 | Patent publication No.: US-20140113891-A1|Assignees: University of Maryland, Baltimore [US]; STC.UNM [US] | IPC: C07D407/12; A61K31/4245;C07D271/12; A61K31/41; C07D257/04; A61K31/423; C07D263/58; A61K31/4184;C07D235/28; A61K31/404; C07D209/30; A61K31/428; C07D277/74; A61K31/4439;C07D401/12; A61K31/433; C07D285/14; A61K31/553; C07D267/18; A61K31/341;A61K31/436; A61K31/495; A61K31/175; A61K45/06 | Oldest priority date: 2008-04-10 | Publication date: 2014-04-24

Score: 12.892465 | Text size: 144346 | Find: similardocuments

Compounds identifiedby CADD screening were purchased from ChemBridge, ChemDiv,MayBridge, MDD, Nanosyn, Specs, Timtec, and Tripos.

IDENTIFICATION OF SMALL MOLECULE INHIBITORS OF JUMONJI AT-RICHINTERACTIVE DOMAIN 1A (JARID1A) AND 1B (JARID1B) HISTONE DEMETHYLASE

YAN, Qin [US]; SAYEGH, Joyce[US]

Score: 18.771336 | Text size: 207894 | Find: similardocuments

plus selectedplates from the Maybridge Diversity, ChemBridge MicroFormats, DIVERSetand ChemDivlibraries containing 8- hydroxyquinolone analogs. ...ChemBridge MW-set and ChemDiv compounds YU151035, YU129886,and YU151897 inhibited JARIDIA with IC50 values at or below 3 μΜ ...01305133 3-HYDROXYTYRATvI!NE 51.28 ΥΪ314994ί ChemBridge7963683 51.07 [[image:imgf000118_0003]] ChemDivG889- 1299 58. ...MW-Set 0.81 14.6 Maybridge 0.75 12.9 ChemBridge McF 0.77 13.9 ChemBridge DvS0.78 15ChemDiv 0.81 14.4 ChemBridge McF 0.8 19.25 ChemDiv 0.8117.46 ChemDiv 0,79 18.41 ChemDiv 0.78 17.

SWEET FLAVOR MODIFIER

CatherineTACHDJIAN [US]; DonaldKARANEWSKY [US]; Sara WERNER [US]; VincentDARMOHUSODO [US]; Jeff YAMAMOTO[US]

Score: 10.633806 | Text size: 221031 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

Pro-Neurogenic Compounds

Steven L.McKnight [US]; Joseph M. Ready[US];Andrew A. Pieper[US];Jef K. DeBrabander [US]

Publicationdate: 2014-04-03 | Patent publication No.: US-20140094480-A1|Assignees: Board of Regents of The University of Texas System [US] | IPC: C07D209/86;C07D413/06; C07D405/12; C07D403/12; C07D403/06; C07D401/06; C07D471/04 | Oldest priority date: 2009-01-09 | Publication date: 2014-04-03

Score: 19.449032 | Text size: 286319 | Find: similardocuments

from ChemDiv,Inc. Example 591-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol [[image:EMI-C00108]]Purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00109]] Purchased from ChemDiv, Inc. Example 611-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol [[image:EMI-C00110]]Purchased fromChemDiv, Inc. Example 621-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00111]] Purchased from ChemDiv, Inc. Example 631-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol [[image:EMI-C00112]]Purchased from ChemDiv, Inc. Example

STRUCTURE OF INSULIN IN COMPLEX WITH N- AND C-TERMINAL REGIONS OF THEINSULIN RECEPTOR ALPHA-CHAIN

LAWRENCE,Michael Colin [AU]; MENTING, JohnGerbrandt Tasman [AU]; SMITH, BrianJohn [AU]

Publicationdate: 2014-04-03 | Patent publication No.: WO-2014047673-A1|Assignees: THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH [AU] | IPC: G01N33/483;C07K1/32; C07K14/62; C07K14/72; G01N23/20 | Oldest priority date: 2012-09-25 | Publication date: 2014-04-03

Score: 10.928354 | Text size: 485443 | Find: similardocuments

from, forexample, Maybridge Chemical Co. (Tintagel, Cornwall, UK), AMRI (Budapest,Hungary) and ChemDiv(San Diego, CA), Specs (Delft, TheNetherlands).

INHIBITING MICROBIAL INFECTIONS

Susan M. Egan[US]

Score: 12.685205 | Text size: 127490 | Find: similardocuments

Compoundswere purchased from ChemBridge Corp. (San Diego, Calif.), Chemdiv, Inc. (SanDiego, Calif.), Prestwick Chemicals (Illkirch, France) and MicroSourceDiscovery Systems, Inc.

TETRAZOLO QUINOXALINE DERIVATIVES AS TANKYRASE INHIBITORS

MUELBAIER,Marcel [DE];RAMSDEN, Nigel[GB];THOMSON, Douglas[DE]

Publicationdate: 2014-03-27 | Patent publication No.: WO-2014045101-A1|Assignees: CELLZOME GMBH [DE] | IPC: C07D487/04; A61K31/495; A61K31/5377; A61K31/496; A61K31/541; A61K31/551;A61K31/506; A61K31/497; A61K31/501; A61P37/00; A61P29/00; A61P35/00 | Oldest priority date: 2012-09-21 | Publication date: 2014-03-27

Score: 12.685205 | Text size: 124953 | Find: similardocuments

Aurora FineChemicals Ltd., Graz (AT), AKos Consulting & Solutions Deutschland GmbH,Steinen (DE), ChemDiv.

INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS

Sanjay A. Desai[US];Ajay D. Pillai[IN]

Publicationdate: 2014-03-27 | Patent publication No.: US-20140088082-A1|Assignees: The U.S.A., as represented by the Secretary, Department of Health and HumanServices. [US] | IPC: C07D513/04; C07D417/06; C07D281/16; C07D263/57; A61K45/06; A61K31/4741;A61K31/554; A61K31/433; A61K31/423; A61K31/4245; C07D491/048; C07D413/14 | Oldest priority date: 2008-07-23 | Publication date:2014-03-27

Score: 14.293713 | Text size: 57700 | Find: similardocuments

methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, Calif. or Peakdale MolecularLimited, High Peak, England.

METHODS AND COMPOSITIONS FOR TREATING BETA-THALASSEMIA AND SICKLE CELLDISEASE

Che-Kun JamesShen [TW];Yu-Chi Chou [TW]

Score: 12.484504 | Text size: 137179 | Find: similardocuments

(7-Oxo-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinoline-3,4-dicarboxylicacid) were purchased fromChemDiv Co.

STRUCTURE-GUIDED IDENTIFICATION OF BINDING INTERACTIONS OF HUMAN LAMININRECEPTOR PRECURSOR WITH LAMININ AND IDENTIFICATION OF COMPOUNDS THAT AFFECTBINDING

Daniel Meruelo[US];Kelly Jamieson[US];VincentDiGiacomo [US]

Score: 14.165414 | Text size: 76264 | Find: similardocuments

which werediscovered by searching databases of publically available chemicals(ChemBridge, ChemDiv, Enamine and PubChem), interacted with thereceptor in a similar manner when virtually docked to

PLASMODIAL SURFACE ANION CHANNEL INHIBITORS FOR THE TREATMENT OR PREVENTIONOF MALARIA

Sanjay A. Desai[US]

Publicationdate: 2014-03-20 | Patent publication No.: US-20140079736-A1|Assignees: The United States of America, as represented by the Secretary, Departmentof Health and Human Services [US] | IPC: A61K39/015; A61K31/501; A61K31/519; C07D409/04; A61K31/4741; A61K31/422;C07D413/14; A61K31/517; C07D239/84; A61K31/554; C07K16/20; C07D513/04 | Oldest priority date: 2011-04-12 | Publication date: 2014-03-20

Score: 15.748037 | Text size: 139512 | Find: similardocuments

methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, Calif. or Peakdale MolecularLimited, High Peak, England. ... room temperature using a commercial library of50,000 compounds with >90% purity confirmed by NMR (ChemDiv). Screenswere performed in 384-well format with individual wells containing a singlecompound at

identification of compounds that disperse tdp-43 inclusions

Benjamin Wolozin[US]

Publicationdate: 2014-03-20 | Patent publication No.: US-20140080780-A1|Assignees: Benjamin WOLOZIN [US] | IPC: C07D487/04; A61K31/704; A61K31/365; C07D417/04; C07D401/12; C07D211/34;C07D401/04; C07D215/36; C07D207/36; C07D239/52; C07D211/52; C07D239/94;C07D215/227; C07D403/06; G01N33/50 | Oldestpriority date: 2011-05-20 | Publication date: 2014-03-20

Score: 15.290299 | Text size: 176314 | Find: similardocuments

Exemplaryembodiments of compounds of formulas (I)-(VI) may be obtained commercially from ChemDiv (SanDiego, Calif.; http://us.chemdiv.com), ChemBridge (San Diego, Calif.;http://www.chembridge. ... C279-0807) are available from ChemDiv.

SHP-2 phosphatase inhibitor

Cheng-Kui Qu[US];Wen-Mei Yu [US]; Olgun Guvench[US];Alexander D.Mackerell, Jr. [US]

Score: 13.556976 | Text size: 88255 | Find: similardocuments

chemicallydiverse list of approximately 200 compounds selected via CADD were purchasedfrom ChemDiv(San Diego, Calif.), ChemBridge (San Diego, Calif.

Method for the treatment of hearing loss

Huawei Li [CN]; Albert Edge [US]; Stefan Heller[US]

Score: 12.484504 | Text size: 135167 | Find: similardocuments

availablecompound libraries (suppliers include ChemBridge Corp (San Diego, Calif.)and ChemDiv (San Diego, Calif.)).

METHODS OF TREATING MUSCULAR DYSTROPHY

Ryan Wuebbles[US];Dean Burkin [US]; Ryan Wuebbles[US];Dean Burkin [US]; Dean Burkin [US]; Ryan Wuebbles[US]

Publicationdate: 2014-03-13 | Patent publication No.: US-20140072536-A1|Assignees: Board of Regents of the Nevada System of Higher Education On Behalf of theUniversity of Nevada [US] | IPC: A61K31/661; A61K31/16; A61K31/444; A61K31/343; A61K31/57; A61K45/06;A61K31/5383; A61K31/5377; A61K31/53; A61K31/551; A61K31/5375; A61K31/4418;A61K31/4709 | Oldestpriority date: 2012-09-10 |Publicationdate: 2014-03-13

Score: 14.450268 | Text size: 229478 | Find: similardocuments

Heidelberg);the DIVERSet library (Chembridge Corp., San Diego, Calif.) and compounds fromthe ChemDivlibrary. ... α7 integrin Compound (ObtainedIncreased A7 Expression Commercially from Myotubes + MyoblastsChemDiv LibraryEC100 Myoblasts Only 5α-cholestan-3β-ol- 6-one20 uM + NA 1080-0573

METHODS OF TREATING MUSCULAR DYSTROPHY

BURKIN, Dean[US];WUEBBLES, Ryan[US];BURKIN, Dean[US];WUEBBLES, Ryan[US]

Publicationdate: 2014-03-13 | Patent publication No.: WO-2014040077-A1|Assignees: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION, ON BEHALF OF THEUNIVERSISITY OF NEVADA, RENO [US] | IPC: A61K31/33; A61K31/38; A61K31/395; A61K31/335; A61K31/56; A61P21/04;A61P21/00 | Oldestpriority date: 2012-09-10 | Publication date: 2014-03-13

Score: 10.928354 | Text size: 241764 | Find: similardocuments

Basel,Heidelberg); the DrVERSet library (Chembridge Corp., San Diego, CA) andcompounds from theChemDiv library.

Structure of the C-terminal region of the insulin receptor α -chain and of the insulin-like growth factor receptorα-chain

Michael ColinLawrence [AU]; Brian John Smith[AU];John GerbrandtTasman Menting [AU]; Colin WesleyWard [AU]

Score: 11.918776 | Text size: 210466 | Find: similardocuments

from, forexample, Maybridge Chemical Co. (Tintagel, Cornwall; UK), AMRI (Budapest,Hungary) and ChemDiv(San Diego, Calif.), Specs (Delft, TheNetherlands).

PRO-NEUROGENIC COMPOUNDS

MCKNIGHT, StevenL. [US];PIEPER, AndrewA. [US];READY, Joseph M.[US];DE BRABANDER,Jef, K. [US]; MCKNIGHT, StevenL. [US];PIEPER, AndrewA. [US];READY, Joseph M.[US];DE BRABANDER,Jef, K. [US]

Publicationdate: 2014-02-27 | Patent publication No.: WO-2014031125-A1|Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US] | IPC: A01N43/38;A61K31/405; C07D209/82 | Oldestpriority date: 2012-08-24 | Publication date: 2014-02-27

Score: 17.703602 | Text size: 716992 | Find: similardocuments

[[image:imgf000161_0002]]This compound can be purchased from ChemDiv, Inc. Example 60.l-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:imgf000161_0003]] This compound can be purchased from ChemDiv,Inc. Example 61.l-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:imgf000162_0001]] This compound can be purchased fromChemDiv, Inc. Example62. l-(3,6-dibromo-9H-ca amino)propan-2-ol [[image:imgf000162_0002]] Thiscompound can be purchased from ChemDiv, Inc. Example 63.l-(3,6-dibromo-9H-ca pan-2-ol [[image:imgf000162_0003]] This compound can bepurchased from ChemDiv, Inc. Example 64. l-(3,6-dibromo-9H-caamino)propan-2-ol [[image:imgf000162_0004]] This compound can be purchased fromChemDiv,Inc. Example 65.

INHIBITING GRAM POSITIVE BACTERIA

RICHTER, Stefan[US];MISSIAKAS,Dominique, M. [US]; SCHNEEWIND, Olaf[US]

Score: 11.239684 | Text size: 224124 | Find: similardocuments

Smallmolecule libraries from different vendors (Asinex, ChemBridge, ChemDiv,Enamine, LifeChemicals, Maybridge, TimTec) were tested in duplicate at theNational Screening

Small molecule inhibitors of PDZinteractions

Michael P.Belmares [US]; Kenneth A.Mendoza [US]; Peter S. Lu [US]; David Garman[US];MichaelTymianski [CA]

Score: 15.5924425 | Text size: 158187 | Find: similardocuments

withAccelrys software (Accelrys, San Diego, Calif.) to model and dock a 650,000molecule library (ChemDiv, San Diego, Calif.; Blanca Pharmaceuticals,Mountain View, Calif. ... multiple conformations for each molecule; and, 4)From approximately 650,000 test compounds (ChemDiv, San Diego, Calif.;Blanca Pharmaceutical, Mountain View, Calif.

INHIBITORS OF BACTERIAL DIGUANYLATE CYCLASE

NEIDITCH,Matthew [US]; PARASHAR, Vijay[US];SEMMELHACK,Martin [US];WATERS,Christopher [US]; KARTHIK,Sambanthamoorthy [US];NEIDITCH,Matthew [US]; PARASHAR, Vijay[US];SEMMELHACK, Martin[US]

Publicationdate: 2014-01-16 | Patent publication No.: WO-2014011663-A1|Assignees: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY [US] | IPC: A61K31/10;A61K45/06; A61K31/16; A61K31/165; A61K31/381; A61L2/16 | Oldest priority date: 2012-07-09 |Publicationdate: 2014-01-16

Score: 12.685205 | Text size: 125791 | Find: similardocuments

Thecompounds were obtained from the ChemDiv diversity set, from theMaybrige HF library, from the Chembridge build block set, from the MS2000

QUINOLINONE DERIVATIVES FOR USE IN THE TREATMENT OF AN AUTOIMMUNE DISEASEAND/OR AN INFLAMMATORY DISEASE

Karl FredrikWallner [SE]; Jan PeterOlofsson [SE]; Malin KristinHultqvist [SE]; Benjamin HarryPelcman [SE]

Publicationdate: 2014-01-16 | Patent publication No.: US-20140018384-A1|Assignees: PRONOXIS AB [SE] | IPC: A61K31/4741; C07D215/233; G01N33/50; C07D471/04; A61K31/4375; A61K45/06;C07D491/04; A61K31/47 | Oldestpriority date: 2011-03-18 | Publication date: 2014-01-16

Score: 13.327991 | Text size: 135346 | Find: similardocuments

as describedabove, certain compounds in Table 4 were commercially available and purchasedfrom ChemDivor Enamine.

Identification Of PCNA Targeting Compounds For Cancer Therapy And PCNAFunction Regulation

Zhongyun Dong[US];Matthew Wortman[US];Zonqing Tan [US]; Kelsey Dillehay[US]

Score: 16.750965 | Text size: 83462 | Find: similardocuments

Center(UC-DDC, Cincinnati, Ohio) or were purchased from Chembridge Co (San Diego,Calif.), ChemDiv (San Diego, Calif.), and/or Sigma-Aldrich (StLouis, Mo. ... Center (UC-DDC, Cincinnati, Ohio) or were purchased fromChembridge Co (San Diego, Calif.), ChemDiv (San Diego,Calif.), and/or Sigma-Aldrich (St Louis, Mo.

Compounds that modulate negative-sense, single-stranded RNA virusreplication and uses thereof

Megan L. Shaw[US];Hans-HeinrichHoffmann [US]; AdolfoGarcia-Sastre [US]; Peter Palese[US]

Score: 18.17824 | Text size: 372313 | Find: similardocuments

includedAsinex 1—(12,378 compounds screened out of 12,378) by ASINEX, Winston-Salem,N.C.; ChemDiv 3—(1,760 compounds screened out of 16,544)by ChemDiv Inc., San Diego, Calif.; ChemDiv 4—(14,677compounds screened out of 14,677) by ChemDiv Inc., San Diego,Calif.; ChemDiv 5—(1,249 compounds screened out of 1,249)by ChemDiv Inc., San Diego, Calif.; ENAMINE 2—(352 compoundsscreened out of 26,576) by ENAMINE Ltd. ... Lead compound C2 was identified ina screen of the ChemDiv 4 source library (14,677compounds; ChemDiv Inc., San Diego, Calif., USA).

PLANT GENES THAT CONFER RESISTANCE TO TRICHOTHECENE MYCOTOXINS ANDFUSARIUM HEAD BLIGHT

Nilgun ErekenTumer [US];John EdwardMcLaughlin [US]; Mohamed AnwarBin-Umer [US]

Score: 13.327991 | Text size: 125980 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

SASPASE-FLG2 COMPLEX, MODULATING AGENTS, AND USES

DominiqueBernard [FR]; AgnesThomas-Collignon [FR]; Roger Rozot [FR]; Benoit Muller[FR]

Score: 18.326208 | Text size: 114176 | Find: similardocuments

THIOXOTHIAZOLIDINE INHIBITORS

Brian J. GEISS[US];Susan M. KEENAN[US];Hillary Jo BEEK[US]

Publicationdate: 2014-01-02 | Patent publication No.: US-20140004590-A1|Assignees: State of Colorado acting by and on behalf of the Board of Trustees of theUniversity of Northern Co [US]; Colorado State University Research Foundation[US] |IPC: C12N9/99; C12N7/00 |Oldest priority date: 2012-05-31 | Publicationdate: 2014-01-02

Score: 16.068731 | Text size: 117322 | Find: similardocuments

Compoundswere obtained from ChemDiv and Hit2Lead. ... The fourcompounds from Table 1 and Scheme A were ordered in 5 mg quantities from ChemDiv andHit2Lead.

Screening method for compounds that promote differentiation of inner earprogenitor cells

Stefan Heller[US];Albert Edge [US]

Score: 12.484504 | Text size: 138060 | Find: similardocuments

availablecompound libraries (suppliers include Chembridge Corp (San Diego, Calif.)and ChemDiv (San Diego, CA)).

Compositions and methods for apoptosis modulators

Jay Jie-Qiang Wu[US];Ling Wang [US]

Publicationdate: 2013-12-31 | Patent publication No.: US-08618110-B2|Assignees: VM Discovery Inc. [US] | IPC: A61K31/5377; A61K31/496; A61K31/454; A61K31/422; A61K31/4192; C07D487/04;C07D417/14; C07D413/14; C07D413/12; C07D413/10; C07D405/14; C07D401/14;C07D401/06; C07D403/14; C07D403/10; C07D403/06 | Oldest priority date: 2007-08-10 | Publication date: 2013-12-31

Score: 12.484504 | Text size: 128909 | Find: similardocuments

Inhibitors of the plasmodial surface anion channel as antimalarials

Sanjay A. Desai[US];Ajay D. Pillai[IN]

Publicationdate: 2013-12-31 | Patent publication No.: US-08618090-B2|Assignees: The United States of America, as represented by the Secretary, Departmentof Health and Human Services [US] | IPC: A61K31/00 | Oldestpriority date: 2008-07-23 | Publication date: 2013-12-31

Score: 14.557414 | Text size: 52386 | Find: similardocuments

methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, Calif. or Peakdale MolecularLimited, High Peak, England.

Modulators of GTPase and Use In Relevant Treatment

Publicationdate: 2013-12-26 | Patent publication No.: US-20130345277-A1|Assignees: Kansas University Center for Technology Commercialization, Inc. [US];STC.UNM [US] | IPC: A61K31/415; A61K45/06; C07D231/06 | Oldest priority date: 2010-06-17 | Publication date: 2013-12-26

Score: 12.290053 | Text size: 134642 | Find: similardocuments

In total1243 compounds were tested in dose response assays based on both MLSMRand ChemDiv virtual screening.

MUCOADHESIVE DEVICES FOR DELIVERY OF ACTIVE AGENTS

HARRIS, Baruch,Z. [US];MURTHY, Vijay,M., K. [US];STEINBERG,David, Adam [US]; PEARLMAN, Rodney[US];ROSEN, Howard,Brian [US];LANGER, Robert,Samuel [US];BARASH, Hila,Epstein [null]; BEHR, Jonathan,Robert [US];MITRAGOTRI,Samir, Suresh [US]; HARRIS, Baruch,Z. [US];MURTHY, Vijay,M., K. [US];STEINBERG,David, Adam [US]; PEARLMAN, Rodney[US];ROSEN, Howard,Brian [US];LANGER, Robert,Samuel [US];BARASH, Hila,Epstein [null]; BEHR, Jonathan,Robert [US];MITRAGOTRI,Samir, Suresh [US]

Score: 12.290053 | Text size: 145049 | Find: similardocuments

fromcommercial and academic sources, for example, from Sigma- Aldrich(www.sigmaaldrich.com), ChemDiv(www.chemdiv.com), Evotec(www.evotec.com ), or ICCB (iccb.med.harvard.

uPAR-uPA INTERACTION INHIBITORS AND METHODS FOR TREATING CANCER

Samy Meroueh[US]

Publicationdate: 2013-12-19 | Patent publication No.: US-20130338144-A1|Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] | IPC: C07D261/20;G01N33/50 | Oldestpriority date: 2011-03-03 | Publication date: 2013-12-19

Score: 13.327991 | Text size: 112556 | Find: similardocuments

In total,nearly 5 million lead-like compounds from six vendors (ChemDiv,ChemBridge, Enamine, Aurora, IBScreen) listed on ZINC8 website (105.

THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES

Robert P.RICCIARDI [US]

Publicationdate: 2013-12-19 | Patent publication No.: US-20130338117-A1|Assignees: The Trustees of the University of Pennsylvania [US] | IPC: A61K31/65;A61K31/198; A61K31/496; A61K31/519; A61K31/473; A61K31/429; A61K31/352;A61K31/341; A61K31/357; A61K31/427; A61K31/42; A61K31/10; A61K31/351 | Oldest priority date: 2007-02-06 | Publication date: 2013-12-19

Score: 17.610455 | Text size: 171977 | Find: similardocuments

A total of45,832 chemical compounds from the following libraries: ChemDiv 3(16,544 compounds), MixCommercial 5 (268 compounds), Maybridge 4 (4,576compounds), ActiMol ... 59 (6.9%) 57 (6.7%) 54 (6.3%) ICBG Fungal Extracts 2460 18 (3.9%) 30 (6.5%) 24 (5.2%) Synthetic ChemDiv 3 16,54421 (0.1%) 64 (0.4%) 89 (0.5%) Compounds MixCommercial 5 268 0 (0.0%) 0 (0.0%) 1(0. ... A total of 45832 synthetic compounds, representing 11 independentlibraries (ChemDiv 3 (16544 compounds), MixCommercial 5 (268compounds), Maybridge 4 (4576 compounds), ActiMol TimTec ... or failed to blockviral infection. bThe synthetic compounds belong to the followinglibraries: ChemDiv 3 (library 1); Maybridge 4 (library 3);ActiMol TimTec (library 4); and Bionet 2 (library 5).

COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS

KimberlyHartwell [US]; Malcolm A.S.Moore [US];David T. Scadden[US];Stuart L.Schreiber [US]; Todd R. Golub[US];Benito Munoz[US];Benjamin L.Ebert [US];Andrew M. Stern[US];Peter G. Miller[US];D. GaryGilliland [US]; Anne Van DykCarpenter [US]; David J. Logan[US];Joseph Negri[US];Nicola Tolliday[US];Alykhan Shamji[US];SiddharthaMukherjee [US]; Alison Stewart[US]

Publicationdate: 2013-12-19 | Patent publication No.: US-20130338092-A1|Assignees: The Broad Institute, Inc. [US]; The General Hospital Corporation [US];Dana-Farber Cancer Institute, Inc. [US]; The Brigham and Women's Hospital, Inc.[US]; President and Fellows of Harvard College [US]; Sloan-Kettering Institutefor Cancer Research [US] | IPC: G01N33/50; A61K31/4184; A61K31/395; A61K31/428; A61K31/423; A61K31/704;A61K31/4745; A61K31/405; A61K31/4418; A61K31/366; A61K31/22; A61K31/167;A61K31/444 | Oldestpriority date: 2011-02-19 | Publication date: 2013-12-19

Score: 10.928354 | Text size: 235910 | Find: similardocuments

HDAC) enzymeinhibitors Commercial A 2240 Commercial libraries (TimTec, Maybridge and ChemDiv)Kinase Biased 6080 Computationally selected for ATP binding site interactorsNatural Products 1600

Pyrimido-pyrrolo-quinoxalinedione inhibitors of cystic fibrosistransmembrane conductance regulator protein and uses therefor

Alan S. Verkman[US];LukmaneeTradtrantip [US]

Publicationdate: 2013-12-17 | Patent publication No.: US-08609661-B2|Assignees: The Regents of the University of California [US] | IPC:A61K31/519; A61P1/00; A61P1/12; A61P13/12 | Oldest priority date: 2009-08-10 | Publication date: 2013-12-17

Score: 15.5924425 | Text size: 154264 | Find: similardocuments

to identifyCFTR inhibitors included approximately 105,000 synthetic small moleculesfrom ChemDiv (San Diego, Calif.) and Asinex (San Diego, Calif.... Structure-activity analysis was performed using analogs purchasedfrom ChemDiv and Asinex.

Compounds for modulating TLR2

Robert W.Finberg [US]; Evelyn A.Kurt-Jones [US]; Shenghua Zhou[US]

Publicationdate: 2013-12-17 | Patent publication No.: US-08609663-B2|Assignees: University of Massachusetts [US] | IPC:A61K31/4725;A61K31/496; A61K31/454; A61K31/42; A61K31/422 | Oldest priority date: 2009-11-18 | Publication date: 2013-12-17

Score: 15.290299 | Text size: 148927 | Find: similardocuments

Othercommercial sources include ChemDiv, ChemBridge, Aurora, Tim Tec, andScientific exchange product list. ... Compound libraries screened includedthose from ChemDiv, Maybridge, ChemBridge, Biomol-TimTec, and someFungal Extracts.

Substituted triazolo[1,5-A]pyrimidines as antiviral agents

Andrea Cuconati[US];Timothy M. Block[US];Xiaodong Xu [US]

Publicationdate: 2013-12-17 | Patent publication No.: US-08609668-B2|Assignees: Philadelphia Health & Education Corporation [US]; Institute ForHepatitis and Virus Research [US] | IPC: A61K31/519; A61P31/20; C07D487/04 | Oldest priority date: 2006-05-04 | Publication date: 2013-12-17

Score: 18.874147 | Text size: 70937 | Find: similardocuments

Compoundscan also be obtained from ChemDiv, Inc. (San Diego, Calif. ...The IHVR small molecule collection consists of 80,288 compounds from thecomplete libraries of ChemDiv, Inc. (San Diego, Calif.),Asinex Inc. (Winston-Salem, N.C.), Chembridge Inc. (San Diego, Calif. ...Resynthesis of HBF-0259 and other compounds was carried out by ChemDivInc. Analogues of HBF-0259 and other compounds were obtainedfrom ChemDiv, Asinex, Chembridge, and Maybridge. High throughputassay and compound screen.

DEFENSIN-LIKE MOLECULES AS NOVEL ANTIMICROBIAL AGENTS

Erik DE LEEUW[US];Alexander D.MACKERELL, JR. [US]

Publicationdate: 2013-12-12 | Patent publication No.: US-20130331413-A1|Assignees: UNIVERSITY OF MARYLAND, BALTIMORE [US] |IPC: A61K31/428; A61K31/351; A61K31/4709; A61K31/09; A61K31/05; A61K31/404; A61K31/4174|Oldestpriority date: 2012-06-06 |Publicationdate: 2013-12-12

Score: 14.039395 | Text size: 88515 | Find: similardocuments

Maybridge(Thermo Fisher Scientific Inc., Wattham, Mass.), ChemBridge (San Diego,Calif.), and ChemDiv (San Diego, Calif.), which contain 59676,482276, and 533143 compounds, respectively.

ANTIBIOTIC COMPOUNDS ANDCOMPOSITIONS, AND METHODS FOR IDENTIFICATION THEREOF

SMITH, Gerald,R. [US];AMUNDSEN, Susan,K. [US];KARABULUT,Ahmet, C. [US]; BANNISTER,Thomas,D. [US]; NAIR, Reji,Narayanan [US]

Publicationdate: 2013-09-26 | Patent publication No.: WO-2013142628-A2|Assignees: FRED HUTCHINSON CANCER RESEARCH CENTER [US]; THE SCRIPPS RESEARCH INSTITUTE[US] |IPC: A61K31/519; A61K31/497; A61K31/495; A61K31/428; A61P31/04; A61P31/00 | Oldest priority date: 2012-03-20 | Publication date: 2013-09-26

Score: 12.290053 | Text size: 148228 | Find: similardocuments

2, 3, and 7(Vitas-M lab); Compounds 1 1 and 13 (Enamine); Compound 15 (Maybridge);Compound 12 (ChemDiv); and Compounds 16, 17 and 18 (Life Chemicals,Burlington, Canada).

Targeting Human Thymidylate Kinase Induces DNA Repair Toxicity inMalignant Tumor Cells

Zee-Fen Chang[TW];Jim-Min Fang[TW];Chun-Mei Hu [TW]; Ming-Tyng Yeh[TW]

Publicationdate: 2013-09-26 | Patent publication No.: US-20130252953-A1|Assignees: Zee-Fen Chang [TW]; Jim-Min Fang [TW]; Chun-Mei Hu [TW]; Ming-Tyng Yeh [TW]|IPC: C07D513/04; C07D275/06; C07D275/04 | Oldest priority date: 2010-11-29 | Publication date: 2013-09-26

Score: 10.928354 | Text size: 198992 | Find: similardocuments

2010) wasmodified and used to screen 21,120 structurally diversified compounds selectedfrom ChemDivlibrary (San Deigo, USA).

Methods to identify USP1 deubiquitinating enzyme complex inhibitors

Alan D. D'Andrea[US]

Score: 11.918776 | Text size: 162193 | Find: similardocuments

consists ofknown bioactive libraries, natural product libraries, and commercial librariessuch as ChemDiv, ChemBridge etc.

METHOD TO PREVENT CANCER METASTASIS AND INHIBIT INFLAMMATION BY INHIBITIONOF P68 INTERACTION WITH CALMODULIN

LIU, Zhi-Ren[US];WANG, Haizhen[US];LIU, Zhi-Ren[US]

Publicationdate: 2013-09-19 | Patent publication No.: WO-2013138484-A1|Assignees: PRODA BIOTECH LLC [US] | IPC: C07K19/00; A61K38/00; C12Q1/68; A61P35/04; A61P29/00; A61P35/00 | Oldest priority date: 2012-03-14 | Publication date: 2013-09-19

Score: 13.327991 | Text size: 94060 | Find: similardocuments

of chemicallibraries including but not limited to ChemBridge Corporation (San Diego, CA), ChemDiv (SanDiego, CA), Life Chemicals (Orange, CT), and Maybridge (Cornwall, UK).

POSITIVE ALLOSTERIC MODULATORS FOR MELANOCORTIN RECEPTORS

CONE, Roger, D.[US];SEBAG, Julien,A. [US];PANTEL, Jacques[FR];WILLIAMS,Savannah, Y. [US]; WEAVER, C.,David [US];SULIKOWSKI,Gary, A. [US]; LINDSLEY, Craig,W. [US];PORTONOVA,Padma, S. [US]; ZHANG, Chao [US]; CONE, Roger, D.[US];SEBAG, Julien,A. [US];PANTEL, Jacques[FR];WILLIAMS,Savannah, Y. [US]; WEAVER, C.,David [US];SULIKOWSKI,Gary, A. [US]; LINDSLEY, Craig,W. [US];PORTONOVA,Padma, S. [US];ZHANG, Chao [US]

Score: 14.293713 | Text size: 60592 | Find: similardocuments

from theVanderbilt Small Molecule Library, which includes over 160,000 compoundsobtained from ChemDivand ChemBridge. [0069] The present inventionis illustrated by the following examples.

DEFENSIN-LIKE MOLECULES AS NOVEL ANTIMICROBIAL AGENTS

Erik De Leeuw[US];Alexander D.MacKerell, Jr. [US]

Publicationdate: 2013-09-05 | Patent publication No.: US-20130231376-A1|Assignees: UNIVERSITY OF MARYLAND, BALTIMORE [US] |IPC: A61K31/428; A61K31/351; A61K31/05; A61K31/045 | Oldest priority date: 2010-11-04 | Publication date: 2013-09-05

Score: 19.160593 | Text size: 60059 | Find: similardocuments

FIG. 11depicts chemical structures, ID number, Molecular Weight and Chemical Formulaof ChemDivCorporation compounds tested for possible use with thepresent methods. FIG. ... Maybridge (Thermo Fisher Scientific Inc., Wattham,Mass.), ChemBridge (San Diego, Calif.), and ChemDiv (SanDiego, Calif. ... 6 compounds based on side-chain similarity, 13 compoundsbased on whole-chain similarity ChemDiv: 5 compounds based onside-chain similarity, 8 compounds based on whole-chain similarity ... FIG. 11depicts the Chemical structures, ID number, Molecular Weight and ChemicalFormula of ChemDiv Corporation compounds. FIG.

UNDERCARBOXYLATED/UNCARBOXYLATED OSTEOCALCIN INCREASES BETA-CELLPROLIFERATION, INSULIN SECRETION, INSULIN SENSITIVITY, GLUCOSE TOLERANCE ANDDECREASES FAT MASS

KARSENTY, Gerard[US];DUCY, PatriciaF. [US]

Publicationdate: 2013-09-04 | Patent publication No.: EP-2073832-B1|Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: A61K38/39;G01N33/50; A61K47/48 | Oldestpriority date: 2007-06-19 | Publication date: 2013-09-04

Score: 8.557886 | Text size: 379600 | Find: similardocuments

External link

Small molecules that replace or agonize p53 function

Rabizadeh,Shahrooz [US]; Niazi, Kayvan[US];Bredesen, DaleE. [US]

Publicationdate: 2013-09-04 | Patent publication No.: EP-2633858-A2|Assignees: Buck Institute for Age Research [US] | IPC:A61K31/555; A61P35/00; A61K31/4418; A61K31/505; G01N33/50 | Oldest priority date: 2004-08-20 | Publication date: 2013-09-04

Score: 19.10261 | Text size: 51211 | Find: similardocuments

of ChemBridge DiverSet E, Bionet 1, CEREP, Maybridge 1, Maybridge 2, Peakdale 1,Peakdale 2, ChemDivCombilab and International, Mixed CommercialPlate 1, Mixed Commercial Plate 2, Mixed Commercial ... compounds), Maybridge 2(704 compounds), Peakdale 1 (2,816 compounds), Peakdale 2 (352 compounds),ChemDiv Combilaband International (28,864 compounds), Mixed Commercial Plate 1 (352 compounds),Mixed ... of Chem Bridge DiverSet E, Bionet 1, CEREP, Maybridge 1, Maybridge 2,Peakdale 1, Peakdale 2,ChemDiv Combilab and International, MixedCommercial Plate 1, Mixed Commercial Plate 2, Mixed Commercial ... of ChemBridge DiverSet E, Bionet 1, CEREP, Maybridge 1, Maybridge 2, Peakdale 1,Peakdale 2,ChemDiv Combilab and International, Mixed CommercialPlate 1, Mixed Commercial Plate 2, Mixed Commercial

External link

Therapeutic compounds for blocking DNA synthesis of pox viruses

Robert P.Ricciardi [US]

Score: 17.610455 | Text size: 167176 | Find: similardocuments

BENZODIAZEPINE COMPOUNDS WITH ANTI-FLAVIVIRUS ACTIVITY

CUCONATI, Andrea[US];CHANG, Jinhong[US];BLOCK, Timothy,M. [US];JU-TAO, Guo [US]

Score: 15.639392 | Text size: 22461 | Find: similardocuments

Compoundlibrary: 26.900 compounds from a library (ChemDiv Inc.) were tested at asingle concentration of 10 micromolar.

Compositions and Methods Useful for the Treatment and Diagnosis ofInflammatory Bowel Disease

Joshua R.Friedman [US]; Adam Zahm [US]; Meena Thayu [US]

Score: 13.793969 | Text size: 97123 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Compositions and Methods for Reducing Cancer Cell Proliferation andModulating Importin-Beta Function

Karsten Weis[US];Rebecca Heald[US];Jonathan F.Soderholm [US]; Stephen L. Bird[US];Petr Kalab [US]

Score: 12.892465 | Text size: 122725 | Find: similardocuments

Compoundswere from ChemBridge, ChemDiv, SPECS, ChemRX, and Microsource.

Dimethylarginine Dimethylaminohydrolase Inhibitors and Methods of UseThereof

Yohannes T.Ghebremariam [US]; John P. Cooke[US]

Publicationdate: 2013-08-29 | Patent publication No.: US-20130224259-A1|Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/542;A61K31/437; A61M16/14; A61M11/04; A61M15/00; A61K31/4439; A61K31/428 | Oldest priority date:2012-02-14 | Publication date: 2013-08-29

Score: 16.679808 | Text size: 236457 | Find: similardocuments

Center(HTBC) contains over 130,000 small molecules selected from diverse sourcesincluding Sigma,ChemDiv, MicroSource, ChemBridge, the NIH clinicalcollection (NIH CC), National Cancer Institute (NCI), ... compounds such asphenylmercuric acetate (IC50<0.78 μM) and quinone-type compoundssuch as ChemDiv2548-0707 (IC50=5.5 μM) and 2548-0703 (IC50=9.0 μM). ...showing inhibition of human DDAH-1 activity by selected small molecules usingthe CPM assay: A) ChemDiv Compound 2548-0707; B) ChemDiv Compound2548-0703; C) 4-MMP; and D) SCH-202676.

DIMETHYLARGININE DIMETHYLAMINOHYDROLASE INHIBITORS AND METHODS OF USETHEREOF

GHEBREMARIAM,Yohannes, Tsegai [US]; COOKE, John, P.[US]

Publicationdate: 2013-08-22 | Patent publication No.: WO-2013123033-A1|Assignees: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US] | IPC: A61K31/4184;A61K31/4188 | Oldest prioritydate: 2012-02-14 | Publication date: 2013-08-22

Score: 16.679808 | Text size: 242570 | Find: similardocuments

Center(HTBC) contains over 130,000 small molecules selected from diverse sourcesincluding Sigma,ChemDiv, MicroSource, ChemBridge, the NIH clinicalcollection (NIH CC), National Cancer Institute (NCI), ... compounds such asphenylmercuric acetate (IC50 < 0.78 μΜ) and quinone-type compounds suchas ChemDiv2548-0707 (IC50=5.5 μΜ) and 2548- 0703 (IC50=9.0 μΜ). ...showing inhibition of human DDAH- 1 activity by selected small molecules usingthe CPM assay: A) ChemDiv Compound 2548-0707; B) ChemDiv Compound2548-0703; C) 4-MMP; and D) SCH- 202676.

Methods for Producing Enteroendocrine Cells That Make and Secrete Insulin

Chutima Talchai[US];Domenico Accili[US]

Score: 10.928354 | Text size: 187309 | Find: similardocuments

MODULATORS OF TOUSLED KINASE IN CELLULAR PROCESSES

DE BENEDETTI,Arrigo [US];SUNAVALA,Gulshan [US]; DE BENEDETTI,Arrigo [US];SUNAVALA,Gulshan [US]

Score: 11.239684 | Text size: 176295 | Find: similardocuments

the FWCC)screened the Prestwick library, two other proprietary libraries, and a subsetof the ChemDiv library (-6000 compounds).

YEAST CELLS EXPRESSING TAR DNA-BINDING PROTEIN 43 AND USES THEREFOR

LINDQUIST,Susan, L. [US]; GITLER, Aaron D.[US]

Score: 14.039395 | Text size: 88023 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

External link

Association of Rare Recurrent Genetic Variations to Attention-Deficit,Hyperactivity Disorder (ADHD) and Methods of Use Thereof for the Diagnosis andTreatment of the Same

Joseph Glessner[US];Josephine Elia[US];Hakon Hakonarson[US]

Score: 10.633806 | Text size: 237250 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

Pyrrolinone derivative and pharmaceutical composition comprising the same

Hiroyuki Kai[JP];Shunji Shinohara[JP];TakayukiKameyama [JP]

Publicationdate: 2013-07-30 | Patent publication No.: US-08497263-B2|Assignees: Shionogi & Co., Ltd. [JP] | IPC: A61K31/422; A61K31/454; A61K31/551; A61K31/4439; A61K31/4025; C07D413/14;C07D487/04; C07D413/10; C07D207/26; C07D261/06 | Oldest priority date: 2007-03-30 | Publication date: 2013-07-30

Score: 20.863457 | Text size: 432584 | Find: similardocuments

IFLABF0907-1024 432 I-119 [[image:EMI-C00179]] IFLAB F0908-5466 429 I-120[[image:EMI-C00180]]ChemDiv C390-0148 429 I-121 [[image:EMI-C00181]] ChemDiv C390-0158426 I-122 [[image:EMI-C00182]]ChemDiv C390-0130 399 I-123[[image:EMI-C00183]] ChemDiv C390-0241 364 I-124[[image:EMI-C00184]]ChemDiv C390-0577 350 I-125[[image:EMI-C00185]] ChemDiv C390-0573 346 I-126 [[image:EMI-C00186]]ChemDiv C390-0587332 I-127 [[image:EMI-C00187]] ChemDiv C390-0571 324 I-128[[image:EMI-C00188]]ChemDiv C390-0605 324 I-129[[image:EMI-C00189]] ChemDiv C390-0540 310 I-130[[image:EMI-C00190]]ChemDiv C390-0594 306 I-131[[image:EMI-C00191]] ChemDiv C390-0569 304 I-132[[image:EMI-C00192]]ChemDiv C390-0545 304 I-133[[image:EMI-C00193]] CSC D50050981 297 I-134 [[image:EMI-C00194]]ChemDiv C390-0565

Pro-Neurogenic Compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Publicationdate: 2013-07-25 | Patent publication No.: US-20130190339-A1|Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US] | IPC: C07D209/88;C07D413/06; C07D403/06; C07D471/04; C07D403/12; C07D401/06; C07D209/08 | Oldest priority date:2009-01-09 | Publication date: 2013-07-25

Score: 18.775887 | Text size: 432486 | Find: similardocuments

from ChemDiv,Inc. Example 591-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol [[image:EMI-C00129]]Purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00130]] Purchased from ChemDiv, Inc. Example 611-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol [[image:EMI-C00131]]Purchased fromChemDiv, Inc. Example 621-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00132]] Purchased from ChemDiv, Inc. Example 631-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol [[image:EMI-C00133]]Purchased from ChemDiv, Inc. Example

TREATMENT OF ABNORMALITIES OFGLUCOSE METABOLISM WITH AN ANTAGONIST OF INHIBITOR OF DIFFERENTIATION 1

Mia Akerfeldt[AU];Ross Laybutt[AU]

Publicationdate: 2013-07-04 | Patent publication No.: US-20130171158-A1|Assignees: GARVAN INSTITUTE OF MEDICAL RESEARCH [AU] |IPC: A61K38/17; A61K31/165; A61K31/495; A61K31/4725; A61K31/519; A61K31/40;A61K31/554; A61K31/445; A61K31/381; A61K31/36; A61K31/366; A61K31/4162;A61K31/496; A61K31/5377; A61K31/713 | Oldestpriority date: 2010-06-30 | Publication date: 2013-07-04

Score: 15.906768 | Text size: 115670 | Find: similardocuments

Forexample, Chemdiv Inc produces1-(4-methoxybenzyl)-4-(2,4,5-trimethoxybenzyl)piperazine; ...dibenzo[b,f][1,4]thiazepin-10(11H)-yl]acetamide from Chemdiv Inc. Ethyl1-(3-[(2,5-dimethyloxyphenyl)amino]-3-oxopropyl)-4-piperidinecarboxylatehydrochloride; ethyl

ANTI-CANCER COMPOUNDS TARGETING RAL GTPASES AND METHODS OF USING THE SAME

THEODORESCU, Dan[US];WEMPE, Michael,Fitzpatrick [US]; ROSS, David [US]; MEROUEH, Samy[US];SCHWARTZ,Martin, A. [US]; REIGAN, Phillip[US]

Publicationdate: 2013-06-27 | Patent publication No.: WO-2013096820-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO [US]; THE UNIVERSITY OF VIRGINIAPATENT FOUNDATION [US]; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION[US] |IPC:A61K31/4162|Oldestpriority date: 2011-12-21 | Publication date: 2013-06-27

Score: 12.685205 | Text size: 136598 | Find: similardocuments

To do so,RalA- GDP was set up for docking, and the ChemDiv library(V2006.

Proteasome inhibitors having chymotrypsin-like activity

HarshaniLawrence [US]; Yiyu Ge [US]; Said M. Sebti[US];Wayne Guida [US]

Publicationdate: 2013-06-18 | Patent publication No.: US-08466157-B2|Assignees: University of South Florida [US]; H. Lee Moffitt Cancer Center and ResearchInstitute, Inc. [US] | IPC: A61K31/47; A61K31/497; C07D215/00; C07D333/08; C07D401/00 | Oldest priority date: 2009-03-06 | Publication date: 2013-06-18

Score: 16.234026 | Text size: 126837 | Find: similardocuments

The inventionincludes a small molecule HLM-008182, identified from 20,000 in-house ChemDiv library,was confirmed by in-house synthesis as a proteasome chymotrypsin-likeinhibitor. ... proteasome inhibitors, HLM-008182 (1) (FIG. 2) was identified asa ‘hit’ from a 20,000 in-house ChemDiv library that showspotent inhibition against chymotrypsin-like proteasome activity with an IC50

INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS

Alan S. Verkman[US];Ricardo De LaFuente Gonzalez [ES]

Publicationdate: 2013-06-06 | Patent publication No.: US-20130143765-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: C40B30/06;C07D333/80; C07D277/46; C07D409/12; C07D333/68; C07D277/42; A61K31/426;A61K31/381 | Oldestpriority date:2007-12-14 | Publication date: 2013-06-06

Score: 14.719831 | Text size: 192707 | Find: similardocuments

Compoundsfor primary screening were purchased from ChemDiv (San Diego,Calif. ... Compounds for the secondary screening were purchased from ChemDiv andAsinex.

INHIBITORS OF PHOSPHODIESTERASES 11 (PDE11) AND METHODS OF USE TO ELEVATECORTISOL PRODUCTION

HOFFMAN, CharlesStuart [US];CEYHAN, Ozge[US]

Score: 14.592621 | Text size: 347090 | Find: similardocuments

1 (0.8%; 68hits from 8,518 compounds), Chembridge 3 (0.7%; 74 hits from 10,560 compounds),and ChemDiv6 (0.64%; 283 from 44,000 compounds) libraries. Incontrast, the lowest frequency of hits was observed in theChemDiv 1library (0. ... four different companies (BCl l-15, Enamine T0515-1965; BC11-19, Maybridge BTB 12009; BCl l-28, ChemDiv K405-0344; BCll-38, Life Chemicals F0579-0060).

Estrogen receptor modulators and uses thereof

William J. Welsh[US];Ching Y. Wang[US];Ni Ai [US]

Publicationdate: 2013-06-04 | Patent publication No.: US-08455537-B2|Assignees: University of Medicine and Dentistry of New Jersey [US] | IPC: A61K31/40;A61K31/12; C07C253/00; C07D209/48 | Oldestpriority date: 2006-07-06 | Publication date: 2013-06-04

Score: 17.30191 | Text size: 49882 | Find: similardocuments

compoundwherein R4 is OH and R5 is H is referred to herein as “Compound B” or“3257-4404” (ChemDiv, Inc., San Diego, Calif. ... Louis, Mo.), Maybridge(Geel, Belgium), and ChemDiv, Inc. (San Diego, Calif.

Antiviral Compounds and Uses Thereof

Megan Shaw [US]; Hans-HeinrichHoffmann [US]; AdolfoGarcia-Sastre [US]; Peter Palese[US]

Score: 13.019692 | Text size: 303085 | Find: similardocuments

LeadCompound C2 was identified in a screen of the ChemDiv 4 sourcelibrary (14,677 Compounds; ChemDiv Inc., San Diego, Calif., USA).

Molecules for regulating cell death

Jodi Nunnari[US];AnnCassidy-Stone [US]; Mark Kurth [US]

Score: 13.10661 | Text size: 112951 | Find: similardocuments

1,900 0 0Peakdale 2,800 0 0 Bionet 4,800 6 2 Cerep 4,800 3 2 Maybridge 8,800 22 10 ChemDiv 29,00054 23 KnownBioactives 1,040 1 0 Total 52,100 86 (.0017) 37 (.0007) Smallmolecules were

Heme oxygenase inhibitors, screening methods for heme oxygenaseinhibitors and methods of use of heme oxygenase inhibitors for antimicrobialtherapy

Angela Wilks[US];AlexanderMacKerrel, Jr. [US]; Lena Furci [US]; Pedro Lopes [US]

Score: 20.79865 | Text size: 141250 | Find: similardocuments

Chemicaldiversity compounds Compound ID Formula MW Solvent Solubility Km (uM) E. coliAssay ChemDiv 1 0091-0260 C16H11N3O6 341.2826 EtOH I — — ChemDiv 20139-0251 C10H7NO4 205.1716 EtOH S + —ChemDiv 3 0173-0031 C9H11N4O3223.213 EtOH I — — ChemDiv 4 0812-1008 C15H8N2O3 264.2426 EtOHI — — ChemDiv 5 1300-0270 C10H10N2O2 190.2034 EtOH S — — ChemDiv 61824-0926 C10H9FN4O2 236.2072 EtOH I — — ChemDiv 7 1988-0303C12H10N6O5 318.2507 EtOH I — — ChemDiv 8 2181-0037 C18H16N4O304.3544 EtOH I — — ChemDiv 9 2226-0401 C10H11N3O2 205.2181EtOH S — —ChemDiv 10 2825-0171 C15H11NO3 253.2598 EtOH I — — ChemDiv 114335-0782 C15H11N3O3 281.2732 EtOH I — — ChemDiv 12 4696-0935C12H14O4 222.243 EtOH S + — ChemDiv 13 8005-4121 C13H13NO3231.2535 MeOH S + — ChemDiv 14 8010-0630 C14H13Cl2NO 282.

Compounds that inhibit human DNA ligases and methods of treating cancer

Alan E.Tomkinson [US]; Xi Chen [US]; BarbaraDziegielewska [US]; Alexander D.Mackerell [US]; Shijun Zhong[US];Gerald M. Wilson[US]

Score: 12.892465 | Text size: 154612 | Find: similardocuments

Compoundsidentified by CADD screening were purchased from ChemBridge, ChemDiv,MayBridge, MDD, Nanosyn, Specs, Timtec, and Tripos.

LIN28/LET-7 CRYSTAL STRUCTURES, PURIFICATION PROTOCOLS, AND MOLECULARPROBES SUITABLE FOR SCREENING ASSAYS AND THERAPEUTICS

SLIZ, Piotr [US]; NAM, Yunsun [US]

Publicationdate: 2013-05-16 | Patent publication No.: WO-2013071079-A1|Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: C12N15/11;A61K31/7105; C07K1/18; A61P35/00 | Oldestpriority date: 2011-11-09 | Publication date: 2013-05-16

Score: 9.838301 | Text size: 319986 | Find: similardocuments

2, Prestwick2 Collection, MSDiscovery 1 , Biomol ICCB Know Bioactives, Asinex 1, ChemBridge3, ChemDiv 4 and 6, Life Chemicals 1, and Maybridge 4 and 5.These libraries can be screened using the

INSECT AND TICK G-COUPLED RECEPTORS USEFUL AS TARGETS FOR INSECTICIDESAND COMPOUNDS AND REAGENTS IDENTIFIED USING THE SAME

HILL, Catherine,A. [US];WATTS, Val, J.[US]

Score: 15.290299 | Text size: 213333 | Find: similardocuments

Additionally,a screen of 10,000 chemistries from the ChemDiv library (SanDiego, CA) was completed. ... l,3-dioxolene 5.820 ST095663(phenylethyl)(2-piperazinylquinazolin-4-yl)amine 4.841 (ChemDiv, Inc)G869-0096 N-(4-((4-methyl-6-(phenylamino)pyrimidin-2-yl)amino)phenyl)prop 4.741ionamide G869-0097

Compounds, Compositions, And Methods For Reducing Or Eliminating BitterTaste

Jane V. Leland[US];Louise Slade[US];David Hayashi[US];William P. Jones[US];Peter H. Brown[US];Joseph Gunnet[US];Daniel Lavery[US];Jessica Langer[US];Kambiz Shekdar[US]

Publicationdate: 2013-04-25 | Patent publication No.: US-20130101684-A1|Assignees: Chromocell Corporation [US] | IPC: A23L1/22; C07C251/24; C07C217/58; C07C321/28; C07D319/20; C07D215/48;C07D219/08; C07D215/233; C07C233/25; C07C235/24; C07C43/205; C07D231/14 | Oldest priority date: 2010-04-15 | Publication date: 2013-04-25

Score: 8.94598 | Text size: 322346 | Find: similardocuments

wereobtained from commercial vendors for synthetic and natural compounds, includingVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OR ELIMINATING BITTERTASTE

BRENNAN, FrancisXavier [US];JONES, WilliamP. [US];LELAND, Jane V.[US];HAYASHI, David[US];BRENNAN, FrancisXavier [US];JONES, WilliamP. [US];LELAND, Jane V.[US];HAYASHI, David[US]

Score: 10.928354 | Text size: 203427 | Find: similardocuments

may beobtained from commercial vendors for synthetic and natural compounds, such asVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine, [0297] The

Compounds, Compositions, And Methods For Reducing Or Eliminating BitterTaste

David Hayashi[US];William P. Jones[US];Jane V. Leland[US];Peter H. Brown[US];Joseph Gunnet[US];Daniel Lavery[US];Louise Slade[US];Kambiz Shekdar[US];Jessica Langer[US]

Publicationdate: 2013-04-18 | Patent publication No.: US-20130096209-A1|Assignees: Kraft Foods Global Brands LLC [US]; Chromocell Corporation [US] | IPC: A23L1/22;A61K47/12; A61K47/44; A61K47/22; A61K47/10; A61K47/06; A61K47/08; A61K47/14 | Oldest priority date:2010-04-15 | Publication date: 2013-04-18

Score: 8.557886 | Text size: 402265 | Find: similardocuments

wereobtained from commercial vendors for synthetic and natural compounds, includingVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

Compounds for inhibiting mammalian s-nitrosoglutathione reductase

Sanghani, Paresh[US]

Publicationdate: 2013-04-17 | Patent publication No.: EP-2581451-A1|Assignees: Indiana University Research and Technology Corporation [US] | IPC: C12Q1/25;A61P11/06; A61P11/00; A61P9/00; A61P15/00; A61P17/00; A61P25/28; A61K31/519;A61P29/00; A61P13/00; A61P35/00 | Oldestpriority date: 2008-01-17 | Publication date: 2013-04-17

Score: 12.892465 | Text size: 100041 | Find: similardocuments

Thescreening for GSNOR inhibitors was performed using a library of 60,000compounds from ChemDiv Inc in the Chemical Genomics Corefacility at Indiana University.

External link

Anti-cancer agents based on N-acyl-2, 3-dihydro-1H-pyrrolo[2,3-b]quinoline derivatives and a method of making

Andrei A. Gakh[US];Mikhail Krasavin[RU];Ruben Karapetian[RU];Konstantin A.Rufanov [RU]; IgorKonstantinov [RU]; Elena Godovykh[RU];Olga Soldatkina[RU];Andrey V. Sosnov[RU]

Score: 15.756501 | Text size: 22865 | Find: similardocuments

It was aimedat identifying new small heterocyclic molecules in the ChemDiv, Inc. collectionthat would be specifically inhibitory to DU-145 human prostate carcinoma cellline (a

Compositions and Methods for Inhibiting Human Host Factors Required forInfluenza Virus Replication

Megan Shaw [US]; Peter Palese[US];AdolfoGarcia-Sastre [US]; Silke Stertz[CH];John Young [US]; RenateKönig [US]; Sumit Chanda[US]

Publicationdate: 2013-04-11 | Patent publication No.: US-20130090367-A1|Assignees: Megan Shaw [US]; Peter Palese [US]; Adolfo Garcia-Sastre [US]; Silke Stertz[CH]; John Young [US]; Renate König [US]; Sumit Chanda [US] | IPC: C12N15/113 | Oldest priority date: 2009-12-11 | Publication date: 2013-04-11

Score: 7.032474 | Text size: 568357 | Find: similardocuments

previously(Hoffmann et al., 2008) and diphyllin was identified from a library suppliedby ChemDiv (San Diego, Calif.

Anti-bacterial drug targeting of genome maintenance interfaces

James L. Keck[US];Douglas A.Bernstein [US]

Publicationdate: 2013-04-09 | Patent publication No.: US-08415393-B2|Assignees: Wisconsin Alumni Research Foundation [US] | IPC:A61K31/03; A61K31/085; A61K31/136; A61K31/192; C07C229/58 | Oldest priority date: 2007-05-22 | Publication date: 2013-04-09

Score: 10.633806 | Text size: 584388 | Find: similardocuments

Calif.),from the Maybridge HitFinder library (Thermo Fisher Scientific, Waltham,Mass.), from the ChemDivlibrary (Chemical Diversity Labs, SanDiego, Calif.), or from the Known Bioactive Library—KBA01.

SMALL MOLECULES THAT REPLACE OR AGONIZE P53 FUNCTION

RABIZADEH,Shahrooz [US]; NIAZI, Kayvan[US];BREDESEN, Dale,E. [US]

Score: 17.493702 | Text size: 53938 | Find: similardocuments

External link

SMALL MOLECULE ACTIVATORS OFCALCIUM-ACTIVATED CHLORIDE CHANNELS AND METHODS OF USE

VERKMAN, Alan,S. [US];NAMKUNG, Wan[US];VERKMAN, Alan,S. [US];NAMKUNG, Wan[US]

Score: 15.5924425 | Text size: 144813 | Find: similardocuments

The compoundcollections used for screening included: ~100,000 synthetic small moleculesfrom ChemDiv(San Diego, CA) and Asinex, and -7500 purified naturalproducts from Analyticon (Potsdam, Germany), ... Structure- activity analysiswas done on analogs purchased from ChemDiv and Asinex.

Pro-Neurogenic Compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Publicationdate: 2013-02-14 | Patent publication No.: US-20130040977-A1|Assignees: Board of Regents of The University of Texas System | IPC: C07D209/58;C07D401/06; A61K31/4439; C07D413/06; A61K31/422; C07D209/08; C07D471/14;A61K31/437; C07D403/06; C07D401/12; C07D403/12; A61K31/506; A61K31/4192;A61K31/4155; C07D405/12; A61P25/28; A61P25/18; A61P25/24; A61P25/08; A61P25/16;A61P25/14; A61K31/403 | Oldestpriority date: 2009-01-09 | Publication date: 2013-02-14

Score: 17.703602 | Text size: 720110 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00139]] This compound can be purchased from ChemDiv, Inc.Example61 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00140]] This compound can be purchased from ChemDiv, Inc. Example62 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00141]] This compound can be purchased from ChemDiv, Inc. Example63 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol [[image:EMI-C00142]]This compound can be purchased from ChemDiv, Inc. Example

SWEET FLAVOR MODIFIER

Publicationdate: 2013-02-14 | Patent publication No.: US-20130041046-A1|Assignees: SENOMYX, INC. [US] | IPC: A23L1/236; A61K47/22; A23L2/60; C07D401/12; C07D413/12; C07D471/08;C07D215/42; C07D405/12 | Oldestpriority date: 2011-08-12 | Publication date: 2013-02-14

Score: 10.928354 | Text size: 192014 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

METHODS OF MODIFYING AMYLOID ß OLIGOMERS USING NON-PEPTIDICCOMPOUNDS

KRAFFT, Grant A.[US];PRAY, Todd [US]; GOURE, WilliamF. [US]

Score: 14.165414 | Text size: 88829 | Find: similardocuments

3.2 ChemDiv 6.[[image:ib0006]](E)-2-hydroxy-N'-((1-hydroxynaphthalen-2-yl)ethylene)benzohydrazide 3.8

External link

SMALL MOLECULES FOR THE MODULATION OF MCL-1 AND METHODS OF MODULATINGCELL DEATH, CELL DIVISION, CELL DIFFERENTIATION AND METHODS OF TREATINGDISORDERS

Loren D.Walensky [US]; Michelle L.Stewart [US]; Nicole Cohen[US];Loren D.Walensky [US]; Michelle L.Stewart [US]; Nicole Cohen[US];Loren D.Walensky [US]; Michelle L.Stewart [US]; Nicole Cohen[US]

Publicationdate: 2013-02-07 | Patent publication No.: US-20130035304-A1|Assignees: Loren D. Walensky [US]; Michelle L. Stewart [US]; Nicole Cohen [US] | IPC: A61K31/7034;C07D311/30; A61K31/352; A61P35/00; C07C255/42; A61K31/26; C07D407/04;A61K31/351; C07J43/00; A61K31/58; C07D493/04; A61K31/366; C07C321/30;A61K31/10; C07C39/16; A61K31/055; C07H15/203; C07D405/14; A61K31/498;A61K31/53; C07D409/12; A61K31/5415; C07D279/06; A61K31/54; C07D409/14;A61K31/55; C12N5/071 | Oldestpriority date: 2010-01-29 | Publication date: 2013-02-07

Score: 11.918776 | Text size: 167722 | Find: similardocuments

CellularBiology at Harvard Medical School and employed commercial libraries (Asinex,Chembridge,ChemDiv, Enamine, Life Chemicals, and Maybridge).

OSTEOCALCIN AS A TREATMENT FOR MALE REPRODUCTIVE DISORDERS

Gerard Karsenty[US];Patricia F. Ducy[US];Gerard Karsenty[US];Patricia F. Ducy[US];Gerard Karsenty[US];Patricia F. Ducy[US]

Publicationdate: 2013-01-31 | Patent publication No.: US-20130028902-A1|Assignees: The Trustees of Columbia University in the City of New York [US] | IPC: A61K38/22;A61P15/10; G01N33/566; A61K39/395; A61K31/713; A61P15/16; A61P15/08; A61K31/366|Oldestpriority date: 2010-01-19 | Publication date: 2013-01-31

Score: 9.838301 | Text size: 287210 | Find: similardocuments

MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USESTHEREOF

John J. Turchi[US];Sarah Shuck [US]; John J. Turchi[US];Sarah Shuck [US]; John J. Turchi[US];Sarah Shuck [US]

Publicationdate: 2013-01-31 | Patent publication No.: US-20130028989-A1|Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] | IPC: A61K31/5377;A61K31/415; A61K31/4155; A61K31/4741; A61P35/00; A61P31/00; A61K33/24;A61K31/7048; C07D413/14; A61K31/675; A61K31/655; A61K31/7028; A61K31/4375;A61K31/4188; G01N33/566; C12N5/00; C12N5/09; A61K31/4709 | Oldest priority date: 2010-02-05 | Publication date: 2013-01-31

Score: 18.248644 | Text size: 67434 | Find: similardocuments

Pro-neurogenic compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]; Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]; Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Score: 18.939768 | Text size: 452453 | Find: similardocuments

from ChemDiv,Inc. Example 59 1-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol[[image:EMI-C00129]] Purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00130]] Purchased from ChemDiv, Inc. Example 611-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00131]] Purchased fromChemDiv, Inc. Example 621-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00132]] Purchased from ChemDiv, Inc. Example 631-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00133]] Purchased from ChemDiv, Inc. Example

Anti-cancer agents based on 4-(hetero)Ary1-1,2,5-oxadiazol-3-yl Aminoderivatives and a method of making

Andrei A. Gakh[US];Mikhail Krasavin[RU];Ruben Karapetian[RU];Konstantin A.Rufanov [RU]; IgorKonstantinov [RU]; Elena Godovykh[RU];Olga Soldatkina[RU];Andrey V. Sosnov[RU];Andrei A. Gakh[US];Mikhail Krasavin[RU];Ruben Karapetian[RU];Konstantin A.Rufanov [RU]; IgorKonstantinov [RU]; Elena Godovykh[RU];Olga Soldatkina[RU];Andrey V. Sosnov[RU];Andrei A. Gakh[US];Mikhail Krasavin[RU];Ruben Karapetian[RU];Konstantin A.Rufanov [RU]; IgorKonstantinov [RU]; Elena Godovykh[RU];Olga Soldatkina[RU];Andrey V. Sosnov[RU]

Score: 15.756501 | Text size: 24128 | Find: similardocuments

It was aimedat identifying new small heterocyclic molecules in ChemDiv, Inc. collectionthat would be specifically inhibitory to DU-145 human prostate carcinoma cellline (a

YEAST CELLS EXPRESSING AMYLOID BETA AND USES THEREFOR

Kent E.S.Matlack [US]; Susan L.Lindquist [US]; Kent E.S.Matlack [US]; Susan L.Lindquist [US]; Kent E.S.Matlack [US]; Susan L.Lindquist [US]

Score: 14.039395 | Text size: 76388 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

PROLYLHYDROXYLASE INHIBITORS AND METHODS OF USE

Rajiv R. Ratan[US];Irina Gazaryan[US];Natalya Smirnova[US];Rajiv R. Ratan[US];Irina Gazaryan[US];Natalya Smirnova[US];Rajiv R. Ratan[US];Irina Gazaryan[US];Natalya Smirnova[US]

Publicationdate: 2013-01-24 | Patent publication No.: US-20130023528-A1|Assignees: CORNELL UNIVERSITY [US] | IPC: A61K31/5383; A61K31/47; A61K31/4709; A61K31/433; A61K31/427; C07D498/04;C07D239/42; C07D215/26; C07D417/12; C07D401/12; A61K31/426; C07D277/38; A61P7/06;A61P9/10; A61P13/12; A61P27/02; A61P25/00; A61P25/16; A61K31/505 | Oldest priority date: 2010-02-23 |Publicationdate: 2013-01-24

Score: 16.068731 | Text size: 133715 | Find: similardocuments

160Validated Hits The screen of 85,000 compounds library (including those fromSpectrum, ChemDiv, AMRI, ChemBridge. ... Extended SAR AnalysisOxyquinolines were purchased from ChemDiv (San Diego, Calif.)and tested in 96-format plates with varied concentrations of an inhibitor (0.

Galactokinase inhibitors

Kent Lai [US]; Klass JanWierenga [US]; Manshu Tang [US]; Kent Lai [US]; Klass JanWierenga [US]; Manshu Tang [US]; Kent Lai [US]; Klass JanWierenga [US]; Manshu Tang [US]

Publicationdate: 2013-01-22 | Patent publication No.: US-08357701-B2|Assignees: University of Miami [US] | IPC: A61K31/4709; A61K31/055; A61K31/10; A61K31/343; A61P3/00; C40B30/00 | Oldest priority date: 2007-08-15 | Publication date: 2013-01-22

Score: 21.21774 | Text size: 164814 | Find: similardocuments

3553-1484;SPBio—001210 (Hexachlorophene); SMP2—000049 Sigma E9259 (Erythrosin B);ChemDiv3—007133 ChemDiv 7218-1483; TimTec1—001324 TimTec ST014236;ChemDiv3—007089 ChemDiv 7218-1459; Maybridge4—001932 JFD03061;TimTec1—000233 TimTec ST000572; ChemDiv3—014119 ChemDiv7218-1576;ChemDiv3—001694 ChemDiv 3241-0272; SPBio—000126Spectrum2—000113 (Bithionol); SPBio—001697 Spectrum2—001629 (Rhodomyrtoxin);ChemDiv3—002334 ChemDiv 3696-0201; ChemDiv3—000903 ChemDiv 1887-0088;TimTec1—001108 TimTec ST014268; Maybridge4—001288 HTS01859; SMP2—000320 SigmaS1014 (Streptonigrin); TimTec1—001055 TimTec ST012305; ChemDiv3—001508 ChemDiv3229-1543;ChemDiv3—007160 ChemDiv 8012-2663; ChemDiv3—001677 ChemDiv 3062-0036;TimTec1—003525 TimTec ST048025; BiomolKI2—000062 BiomolEI-307;ChemDiv3—001693 ChemDiv

Integrin-binding small molecules

Neamati, Nouri[US];Dayam, Raveendra[US]

Publicationdate: 2013-01-16 | Patent publication No.: EP-2298308-B1|Assignees: University Of Southern California [US] | IPC:A61K31/426; C07D277/54; A61P35/00; A61P19/02; A61P19/10; A61P9/10;A61P31/12; A61P1/00; A61P9/00; A61P11/00; A61P17/00; A61P7/00; A61P29/00;A61P37/00; A61P37/08 | Oldestpriority date: 2005-11-14 | Publication date: 2013-01-16

Score: 15.5924425 | Text size: 162920 | Find: similardocuments

A search ofthe Chemical Diversity (ChemDiv, Inc, San Diego, CA) database of 359,224compounds produced 148 hits. ... The novel drug candidates (NVX-188 andanalogues) are synthesized by and purchased fromChemDiv (San Diego,CA). Compounds are stored as 1 mM stock solutions in DMSO at -20°C until use.

External link

COMPOSITIONS AND METHODS FOR TREATING ENTEROBACTERIACEAE

SPINOLA, StanleyM [US];SPINOLA, StanleyM [US]

Publicationdate: 2013-01-10 | Patent publication No.: WO-2013006854-A2|Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] | IPC: A61K31/495;A61K31/404; A61K31/165; A61K31/135; A61P31/00 | Oldest priority date: 2011-07-07 |Publicationdate: 2013-01-10

Score: 18.534403 | Text size: 53560 | Find: similardocuments

structurallydiverse, drug-like, small molecule library of 35,904 compounds was obtainedfrom ChemDiv and ChemBridge collections and was screened at 10μΜ against thewild-type strain, E. coli strain ... library of 170,000 nonredundant, smallmolecule compounds selected from the ChemBridge and ChemDiv collectionsin the Chemical Genomics Core Facility is being screened to identify additional... dihydroquinoline-3-carboxylic acid, a norfloxacin derivative (ChemDiv 5706-4098)that is not in clinical use.

Compounds and assays for controlling Wnt activity

Dakai Liu [US]; Xiaofeng Li [US]; Richard Jin [US]; Yuaxin Liang[US];Wei Cheng [US]; RiddhiBhattacharyya [US]; Guangrong Zhang[US];Dakai Liu [US]; Xiaofeng Li [US]; Richard Jin [US]; Yuaxin Liang[US];Wei Cheng [US]; RiddhiBhattacharyya [US]; Guangrong Zhang[US]

Publicationdate: 2012-12-20 | Patent publication No.: US-20120322717-A9|Assignees: Dakai Liu [US]; Xiaofeng Li [US]; Richard Jin [US]; Yuaxin Liang [US]; WeiCheng [US]; Riddhi Bhattacharyya [US]; Guangrong Zhang [US] | IPC: A61K38/02;C07C309/53; C07C235/56; C07D251/70; C07C229/66; A61K31/538; A61K31/196;A61K31/185; A61K31/277; A61K31/53; A61K31/245; A61K31/366; A61K31/12;A61K31/165; A61K31/167; A61K31/505; A61K31/122; A61K31/235; A61K31/05;A61K31/365; A61K31/343; A61P31/12; A61P25/00; A61P19/00; A61P35/00; A61P3/08;A61P3/06; G01N33/00; C12Q1/02; C12Q1/68; G01N33/53; G01N33/542; C40B30/04;C40B30/02; C12N5/10; C12Q1/66; C07D265/38 | Oldest priority date: 2009-05-22 | Publication date: 2012-12-20

Score: 11.569273 | Text size: 181882 | Find: similardocuments

from the NCldatabase/chemical library as well as commercial database/chemical librariesfrom ChemDiv, Inc.(San Diego, Calif.), Chembridge Corporation (SanDiego, Calif.

THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES

Robert P.RICCIARDI [US]; Robert P.RICCIARDI [US]

Publicationdate: 2012-12-20 | Patent publication No.: US-20120322770-A1|Assignees: Robert P. RICCIARDI [US] | IPC: A61K31/16; A61K31/10; A61K31/198; A61K31/352; A61K31/519; A61K31/196;A61K31/24; A61K31/4196; A61K31/4709; A61K31/404; A61K31/444; A61K31/4985;A61K31/5377; A61K31/4164; A61K31/506; A61K31/42; A61K31/429; A61K31/517;A61K31/65; A61P31/20; C12N9/99 | Oldestpriority date: 2007-02-06 | Publication date: 2012-12-20

Score: 17.610455 | Text size: 171271 | Find: similardocuments

PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS

HADDACH,Mustapha [US]; TRAN, Joe A.[US];PIERRE, Fabrice[US];REGAN, Collin F.[US];RAFFAELE,Nicholas B. [US]; RAVULA, Suchitra[US];RYCKMAN, DavidM. [US];HADDACH,Mustapha [US]; TRAN, Joe A.[US];PIERRE, Fabrice[US];REGAN, Collin F.[US];RAFFAELE,Nicholas B. [US];RAVULA, Suchitra[US];RYCKMAN, DavidM. [US]

Score: 9.838301 | Text size: 319323 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (SanDiego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands),Timtec (Newark, DE), or alternatively can be

TREATMENT AND PREVENTION OF CANCER WITH HMGB1 ANTAGONISTS

YANG, Haining[US];CARBONE, Michele[US];BIANCHI, Marco,E. [IT];YANG, Haining[US];CARBONE, Michele[US];BIANCHI, Marco,E. [IT]

Score: 15.970954 | Text size: 243653 | Find: similardocuments

PROTEOSTASIS REGULATORS

Megan Foley [US]; Bradley Tait[US];Matthew Cullen[US];Megan Foley [US]; Bradley Tait[US];Matthew Cullen[US]

Publicationdate: 2012-12-13 | Patent publication No.: US-20120316193-A1|Assignees: PROTEOSTASIS THERAPEUTICS, INC. | IPC:C07D207/333;C07D401/06; C07D403/06; C07D471/04; C07D405/06; C07D231/12; C07D413/06;C07D417/06; C07D409/06; C07D207/34; A61K31/402; A61K31/454; A61K31/4025;A61K31/4178; A61K31/4745; A61K31/404; A61K31/4155; A61K31/415; A61K31/4535;A61K31/4192; A61P25/28; A61P25/16; A61P25/00; A61P3/10; A61P35/00; C07D207/337|Oldestpriority date: 2011-05-12 | Publication date: 2012-12-13

Score: 10.928354 | Text size: 257380 | Find: similardocuments

Compound A47(also shown below) was purchased from ChemDiv, San Diego, Calif.

INTERFERON-INDUCING COMPOUNDS AND USES THEREOF

Megan Shaw [US]; Mila Ortigoza[US];AdolfoGarcia-Sastre [US]; Peter Palese[US];Megan Shaw [US]; Mila Ortigoza[US];AdolfoGarcia-Sastre [US]; Peter Palese[US]

Publicationdate: 2012-12-06 | Patent publication No.: US-20120308608-A1|Assignees: Megan Shaw [US]; Mila Ortigoza [US]; Adolfo Garcia-Sastre [US]; PeterPalese [US] | IPC: A61K31/404; A61P31/14; A61P31/20; A61P31/22; A61P35/00; A61P25/00;A61P31/04; A61K31/704; A61K31/473; A61K31/4745; A61K31/428; A61K31/4706;A61K31/498; A61K31/502; A61K31/42; A61K31/415; A61K31/422; A61K31/427;A61K31/44; A61K31/55; A61K31/34; A61P31/16 | Oldest priority date: 2011-01-31 | Publication date: 2012-12-06

Score: 17.439129 | Text size: 255124 | Find: similardocuments

MountPleasant, S.C.), Chembridge 3 (10,560 Compounds; ChemBridge Corp., San Diego,Calif.), ChemDiv 2 (8,560 Compounds; ChemDiv, Inc.,San Diego, Calif.), ChemDiv 4 (1,320 Compounds; ChemDiv,Inc., San Diego, Calif.), Enamine 2 (26,576 Compounds; ENAMINE Ltd. ...Compounds; Maybridge Ltd., Trevillett, England), Mixed Commercial Plate 5 (268Compounds from ChemDiv and Maybridge libraries), Peakdale 2(352 Compounds; Peakdale Molecular Ltd.

SMALL MOLECULE MODULATORS OF SIRT1ACTIVITY ACTIVATE P53 AND SUPPRESS TUMOR GROWTH

LU, Hua [US]; ZENG, Shelya[US];MEROUEH, Samy[US];ZHANG, Qi [null]; LU, Hua [US]; ZENG, Shelya[US];MEROUEH, Samy[US];ZHANG, Qi [null]

Publicationdate: 2012-10-04 | Patent publication No.: WO-2012135149-A2|Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] | IPC: A61K31/53;A61K31/5415; A61P35/00 | Oldestpriority date: 2011-03-25 | Publication date: 2012-10-04

Score: 16.234026 | Text size: 108346 | Find: similardocuments

initialcomputational screening of half a million of commercially available compoundsfrom the ChemDivchemical library, the 50 top candidates wereselected for further characterization. ... The compounds for the cell-basedscreen, Inauhzin and its analogues were purchased from Asinex, ChemDiv andChemBridge.

SPIROALKENE CARBOXAMIDE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTORMODULATORS

JORAND-LEBRUN,Catherine [FR]; SWINNEN,Dominique [FR]; GERBER, Patrick[CH];KULKARNI,Santosh [IN]; JORAND-LEBRUN,Catherine [FR];SWINNEN,Dominique [FR]; GERBER, Patrick[CH];KULKARNI,Santosh [IN]

Publicationdate: 2012-10-04 | Patent publication No.: WO-2012130915-A1|Assignees: ARES TRADING S.A. [CH] | IPC: C07D491/107; C07D519/00; A61K31/407; A61P29/00; A61P35/00; A61P37/00 | Oldest priority date: 2011-03-31 | Publication date: 2012-10-04

Score: 11.569273 | Text size: 222016 | Find: similardocuments

Example CD1and CD2 were purchased from ChemDiv, Inc. - 6605 Nancy RidgeDr San Diego, CA, 92121 , USA - (cat.

METHODS OF TREATING FUNGAL INFECTIONS

Kim Lewis [US]; Michael DavidLafleur [US]; Kim Lewis [US]; Michael DavidLafleur [US]

Publicationdate: 2012-10-04 | Patent publication No.: US-20120252820-A1|Assignees: NORTHEASTERN UNIVERSITY [US] | IPC:A61K31/13;A01N43/50; A01N33/04; A61K31/4015; A01N43/36; A61K31/495; A01N43/60; A61K31/16;A01N37/18; A61K31/18; A01N41/06; A61K31/045; A01N31/06; A01P3/00; A61P31/10;A61K31/4174 | Oldestpriority date: 2008-04-22 | Publication date: 2012-10-04

Score: 17.126425 | Text size: 131757 | Find: similardocuments

the NationalInstitutes of Health Molecular Library Screening Center, The ChemBridgeLibrary, the ChemDivLibrary, and the MayBridge Library. ... #Screened S M W TotalHit Rate (%) Asinex 1 12,378 1 12 13 0.11 ChemBridge 3 84485 42 47 0.56 ChemDiv 3 11,968 1 3 1 5 0.04 ChemDiv 41056 2 2 0.19 Enamine 2 26,224 2 25 148 175 0.67 Maybridge 5 3212 2 2 0.06Commercial Total

Small molecule inhibition of intracellular transport

David B. Haslam[US];David B. Haslam[US]

Publicationdate: 2012-10-02 | Patent publication No.: US-08278321-B2|Assignees: Washington University [US] | IPC: A01N43/42; A01N43/40; A61K31/44; A61K31/445; C07D221/22; C07D221/06;C07D211/06 | Oldestpriority date: 2008-12-23 | Publication date: 2012-10-02

Score: 18.541523 | Text size: 133398 | Find: similardocuments

The moleculeis commercially available from ChemDiv of San Deigo, Calif.The structure of GCA is provided in Formula (I): [[image:EMI-C00001]] Analysisof the compound of Formula (I) as obtained from ChemDiv byreverse-phase LC-MS revealed the compound to be present as a 10:1diastereomeric mixture. ... mixture was then determined to be identical to thatobtained as part of a screening library from ChemDiv using 1HNMR and LC-MS (1H NMR 600 MHz (CDCl3) δ 8.78 (d, J=1.5 Hz, 1H), 8.62(dd, J=1. ... Materials and Methods for Examples 1-8: Antibodies and Reagents:Compound GCA was purchased from ChemDiv, reconstituted to 10 mM inDMSO and stored at −20° C. The purity of GCA was confirmed by mass

Therapeutic compounds for blocking DNA synthesis of pox viruses

Robert P.Ricciardi [US]; Robert P.Ricciardi [US]

Score: 17.610455 | Text size: 167017 | Find: similardocuments

A total of45,832 chemical compounds from the following libraries: ChemDiv 3(16,544 compounds), MixCommercial 5 (268 compounds), Maybridge 4 (4,576compounds), ActiMol ... 59 (6.9%) 57 (6.7%) 54 (6.3%) ICBG Fungal Extracts 2460 18 (3.9%) 30 (6.5%) 24 (5.2%) Synthetic ChemDiv 3 16,54421 (0.1%) 64 (0.4%) 89 (0.5%) Compounds MixCommercial 5 268 0 (0.0%) 0 (0.0%) 1(0. ... A total of 45832 synthetic compounds, representing 11 independentlibraries (ChemDiv 3 (16544 compounds), MixCommercial 5 (268compounds), Maybridge 4 (4576 compounds), ActiMol TimTec ... or failed to blockviral infection. bThe synthetic compounds belong to the followinglibraries: ChemDiv 3 (library 1); Maybridge 4 (library 3);ActiMol TimTec (library 4); and Bionet 2 (library 5).

QUINOLINONE DERIVATIVES FOR USE IN THE TREATMENT OF AN AUTOIMMUNE DISEASEAND/OR AN INFLAMMATORY DISEASE

WALLNER, KarlFredrik [SE]; OLOFSSON, JanPeter [SE];HULTQVIST, MalinKristin [SE]; PELCMAN,Benjamin Harry [SE]; WALLNER, KarlFredrik [SE]; OLOFSSON, JanPeter [SE];HULTQVIST, MalinKristin [SE]; PELCMAN,Benjamin Harry [SE]

Score: 13.556976 | Text size: 124315 | Find: similardocuments

as describedabove, certain compounds in Table 4 were commercially available and purchasedfrom ChemDivor Enamine. Table 4. Chemical structure Example Name/V-p-Anisyl-2-(6,7-methyle "nedioxy-4.

SMALL MOLECULE INHIBITORS OF THE ALPHA4-PAXILLIN INTERACTION

Mark Ginsberg[US];ChristianeKummer [DE];Mark Ginsberg[US];ChristianeKummer [DE]

Publicationdate: 2012-09-27 | Patent publication No.: US-20120245194-A1|Assignees: University of California Technology Transfer [US] |IPC: A61K31/435; A61P25/00; A61P11/06; A61P1/00; A61P29/00; A61P35/04;A61P19/04; A61P7/00; A61P7/06; A61P31/14; A61P5/16; A61P35/00; C07D221/06;A61P3/10 | Oldestpriority date: 2009-09-18 | Publication date: 2012-09-27

Score: 18.761955 | Text size: 86245 | Find: similardocuments

Thefollowing libraries were screened: Mixed Commercials 1,2 & 4, ChemDiv 1& 2, Specplus, Maybridge 2 & 3, Peakdale2, Starr Foundation Extracts 1& 2, Philippines Plant ... compounds was screened at a concentration of 16 μg/ml usingthe Mixed Commercials 1,2 & 4, ChemDiv 1 & 2,Specplus, Maybridge 2 & 3, Peakdale2, Starr Foundation Extracts 1 & 2,Philippines Plant ... inhibitor—In dose response ELISA binding assays theinhibitory effect of compound 6-B345TTQ (ChemDiv, San Diego, Calif.) wasverified for the interaction of leupaxin with α4-integrin. Interestingly, anisomer (6-B234TTQ (ChemDiv, San Diego, Calif.

TRICYCLIC PYRAZOL AMINE DERIVATIVES

Pascale Gaillard[FR];IsabelleJeanclaude-Etter [CH]; Vincent Pomel[FR];Eric Sebille[FR];SeenisamyJeyaprakashnarayanan [IN]; MathildeMuzerelle [FR]; Pascale Gaillard[FR];IsabelleJeanclaude-Etter [CH]; Vincent Pomel[FR];Eric Sebille[FR];SeenisamyJeyaprakashnarayanan [IN];Mathilde Muzerelle[FR]

Publicationdate: 2012-09-20 | Patent publication No.: US-20120238545-A1|Assignees: MERCK SERONO SA [CH] | IPC: A61K31/5377; A61K31/553; A61P29/00; A61P37/00; A61P35/00; A61P25/00;A61P11/06; A61P17/14; A61P7/06; A61P31/14; A61P27/16; A61P1/00; A61P11/00;A61P17/00; A61P3/10; A61P15/00; A61P5/16; A61P19/04; A61P21/04; A61P17/06;A61P1/16; A61P25/18; A61P7/00; A61P1/04; C07D495/04 |Oldest priority date: 2009-11-13 | Publicationdate: 2012-09-20

Score: 7.032474 | Text size: 687250 | Find: similardocuments

compound B1,referenced under the Registry Number 931355-99-6, is commercially availablefrom ChemDivCompany. This compound was not used for any pharmaceuticalor medical indication.

MODULATION OF ADIPOSE TRIGLYCERIDE LIPASE FOR PREVENTION AND TREATMENT OFCACHEXIA, LOSS OF WEIGHT AND MUSCLE ATROPHY AND METHODS OF SCREENING THEREFOR

Robert Zimmerman[AT];Rudolf Zechner[AT];GüntherHaemmerle [AT]; GeraldHöfler [AT]; Suman Das [AT]; Achim Lass [AT]; Robert Zimmerman[AT];Rudolf Zechner[AT];GüntherHaemmerle [AT]; GeraldHöfler [AT]; Suman Das [AT]; Achim Lass [AT]

Publicationdate: 2012-09-13 | Patent publication No.: US-20120230943-A1|Assignees: Robert Zimmerman [AT]; Rudolf Zechner [AT]; Günther Haemmerle [AT];Gerald Höfler [AT]; Suman Das [AT]; Achim Lass [AT] | IPC: A61K31/7088;G01N33/573; G01N21/75; A61K31/713; A61K38/20; A61K31/4406; A61K38/19; A61P3/00;A61K31/495; A61K31/235; A61K31/4152; C12Q1/44; A61K38/21 | Oldest priority date: 2009-03-31 | Publication date: 2012-09-13

Score: 17.41611 | Text size: 186509 | Find: similardocuments

Furthermore,the compounds described in Example 3 can be ordered from: ChemDiv, Inc. (“ChemDiv”),6605 Nancy Ridge Drive, San Diego, Calif. 92121, USA (www.chemdiv.com); orASINEX Ltd. ... In particular, compounds 2, 3, 4, 6, 7, 8, and 9 as describedin Example 3 can be obtained from ChemDiv; their ChemDivsupplier'sID numbers are indicated in Example 3. Compound 5 as described in Example 3 canbe

Antimicrobial Compounds

Terence Moy [US]; Annie Conery[US];Kim Lewis [US]; Frederick M.Ausubel [US]; ReadPukkila-Worley [US]; Terence Moy [US]; Annie Conery[US];Kim Lewis [US]; Frederick M.Ausubel [US]; ReadPukkila-Worley [US]

Publicationdate: 2012-09-13 | Patent publication No.: US-20120232110-A1|Assignees: NORTHEASTERN UNIVERSITY [US]; THE GENERAL HOSPITAL CORPORATION [US] | IPC: A61K31/47;A61P31/04; A61K31/4709 | Oldestpriority date: 2009-06-26 | Publication date: 2012-09-13

Score: 18.04004 | Text size: 84087 | Find: similardocuments

BiologyProgram, Broad Institute, Cambridge, Mass.), ChemBridge kinases (San Diego, Calif.), ChemDiv (SanDiego, Calif.), TimTec (Newark, Del. ... Synthesis (DOS) 11,666 1 0.01%ChemBridge kinases Commercial compounds: 8,240 21 0.27% ChemDiv 11,61612 0.10% TimTec 8,512 7 0.08% MayBridge 5,448 3 0.06% ChemBridge 704 1 0.14%Total 53,946b ... Example 6 Antimicrobial Assay Methods Compounds 6, 7, 15 werepurchased from TimTec and ChemDiv, dissolved in DMSO at aconcentration of 5 or 10 mg/ml, and further diluted in DMSO as indicated.

Antimicrobial compounds and methods of use thereof

Eric Skaar [US]; Devin Stauff[US];Olusegun O.Aranmolate [US]; Eric Skaar [US]; Devin Stauff[US];Olusegun O.Aranmolate [US]

Score: 12.685205 | Text size: 128824 | Find: similardocuments

In a furtheraspect, the compound is identified from members of the ChemBridge Libraryand/or the ChemDivLibrary.

uPAR-uPA INTERACTION INHIBITORS AND METHODS FOR TREATING CANCER

MEROUEH, Samy[US];MEROUEH, Samy[US]

Publicationdate: 2012-09-07 | Patent publication No.: WO-2012119079-A1|Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US] | IPC: C07D261/02;C07D261/20; C07D261/06; C07D209/90 | Oldestpriority date: 2011-03-03 |Publicationdate: 2012-09-07

Score: 13.327991 | Text size: 115287 | Find: similardocuments

In total,nearly 5 million lead-like compounds from six vendors (ChemDiv,ChemBridge, Enamine, Aurora, IBScreen) listed on ZINC 8 website (105.

Tetrahydroquinoline derivatives

Nicole CorineRenee Van Straten [NL]; RudolfGijsbertus Van Someren [NL]; Jurgen Schulz[GB];Nicole CorineRenee Van Straten [NL]; RudolfGijsbertus Van Someren [NL]; Jurgen Schulz[GB]

Publicationdate: 2012-09-04 | Patent publication No.: US-08258293-B2|Assignees: MSD OSS B.V. [NL] | IPC: C07D215/08; C07D215/12; C07D215/20; C07D215/38; C07D215/48; C07D401/12;C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D417/12 | Oldest priority date: 2001-07-02 | Publication date: 2012-09-04

Score: 13.327991 | Text size: 103934 | Find: similardocuments

Collection,order nrs 28020-A0839/0039328 (CAS 310456-97-4) and -A0705/0032919 (CAS327981-38-4);ChemDiv.

VIRAL INHIBITORS

FONTOURA,Beatriz [US]; GARCIA-SASTRE,Adolfo [US];VERSTEEG, Gijs[US];ROTH, Michael[US];SATTERLY, Neal[US];FONTOURA,Beatriz [US];GARCIA-SASTRE,Adolfo [US];VERSTEEG, Gijs[US];ROTH, Michael[US];SATTERLY, Neal[US]

Publicationdate: 2012-08-30 | Patent publication No.: WO-2012115945-A1|Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US]; MOUNT SINAISCHOOL OF MEDICINE [US] | IPC: A61K31/4545 | Oldestpriority date: 2011-02-21 | Publication date:2012-08-30

Score: 15.5924425 | Text size: 160182 | Find: similardocuments

as describedabove, all the other compounds in this table can be obtained fromChemBridge, ChemDiv, ComGenex, TimTek, and their purities wereequal or above 90%. FIG. ... Library Library size 200,000 Library compositionCommercially available chemical compounds Source ChemDiv,ChemBridge, Comgenex, TimTek Additional comments Compounds in the libraryrepresent all the

Aryl Urea Derivatives for Treating Obesity

Jason Bloxham[GB];Matthew ColinThor Fyfe [GB]; James Horswill[GB];Revathy PerpetuaJeevaratnam [GB]; John Keily [GB]; Martin JamesProcter [GB]; Karen LesleySchofield [GB]; Salam Shaaban[US];Simon AndrewSwain [GB];PhilippeWong-Kai-In [GB]; Jason Bloxham[GB];Matthew ColinThor Fyfe [GB]; James Horswill[GB];Revathy PerpetuaJeevaratnam [GB]; John Keily [GB]; Martin JamesProcter [GB]; Karen LesleySchofield [GB]; Salam Shaaban[US];Simon AndrewSwain [GB];PhilippeWong-Kai-In [GB]

Publicationdate: 2012-08-23 | Patent publication No.: US-20120214808-A1|Assignees: Prosidion Limited [GB] | IPC: A61K31/5377; C07D277/38; A61K31/381; C07D333/50; C07D333/36; A61K31/17;C07C275/42; A61K31/4164; C07D233/56; A61K31/428; C07D277/82; A61K31/44;C07D213/72; A61K31/5375; C07D295/12; A61K31/505; C07D239/02; C07D413/04;A61P3/04; A61P25/18; A61P25/24; A61P3/00; A61P25/08; A61P25/00; A61K31/426 | Oldest priority date: 2004-08-16 | Publication date: 2012-08-23

Score: 12.484504 | Text size: 142257 | Find: similardocuments

291.2 [M +H]+ 139 [[image:EMI-C00153]] 4-[3-(3- Chlorophenyl)ureido] benzoic acid ethylester ChemDiv 4.33 319.

METHODS FOR IDENTIFYING SUBJECTS WITH A GENETIC RISK FOR DEVELOPING IGANEPHROPATHY

GHARAVI, Ali[US];KIRYLUK,Krzysztof [US]; GHARAVI, Ali[US];KIRYLUK,Krzysztof [US]

Score: 12.290053 | Text size: 173631 | Find: similardocuments

METHODS AND COMPOSITIONS FOR TREATING β-THALASSEMIA AND SICKLE CELL DISEASE

SHEN, Che-Kun,James [null]; CHOU, Yu-Chi[null];SHEN, Che-Kun,James [null]; CHOU, Yu-Chi[null]

Score: 12.484504 | Text size: 143659 | Find: similardocuments

(7-Oxo-7H-benzo[de]benzo[4,5]imidazo[2,l-a]isoquinoline-3,4-dicarboxylicacid) were purchased fromChemDiv Co.

PYRIMIDO-PYRROLO-QUINOXALINEDIONE INHIBITORS OF CYSTIC FIBROSISTRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND USES THEREFOR

Alan S. Verkman[US];LukmaneeTradtrantip [US]; Alan S. Verkman[US];LukmaneeTradtrantip [US]

Publicationdate: 2012-08-16 | Patent publication No.: US-20120208822-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/519;A61P1/00; A61P1/12; A61P13/12 | Oldestpriority date: 2009-08-10 | Publication date: 2012-08-16

Score: 15.5924425 | Text size: 156425 | Find: similardocuments

NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI ORSWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF

CatherineTachdjian [US]; Andrew P. Patron[US];Sara L.Adamski-Werner [US]; Farid Bakir [US]; Qing Chen [US]; VincentDarmohusodo [US];Stephen TerrenceHobson [US];Xiaodong Li [US]; Ming Qi [CN]; Daniel H. Rogers[US];Marketa Rinnova[US];Guy Servant [US]; Xiao-Qing Tang[US];Mark Zoller [US]; Daivd Wallace[US];Amy Xing [US]; Klaus Gubernator[US];CatherineTachdjian [US]; Andrew P. Patron[US];Sara L.Adamski-Werner [US]; Farid Bakir [US]; Qing Chen [US]; VincentDarmohusodo [US]; Stephen TerrenceHobson [US];Xiaodong Li [US]; Ming Qi [CN]; Daniel H. Rogers[US];Marketa Rinnova[US];Guy Servant [US]; Xiao-Qing Tang[US];Mark Zoller [US]; Daivd Wallace[US];Amy Xing [US];Klaus Gubernator[US]

Publicationdate: 2012-08-09 | Patent publication No.: US-20120201763-A1|Assignees: SENOMYX, INC. [US] | IPC: A61K8/49; C07D317/68; C07F9/655; C07C235/46; C07D405/12; C07D319/18;C07D321/10; C07D307/85; C07D263/56; C07D241/24; A61K8/55; A61K8/42; A61K47/22;A61K47/24; A61K47/18; A61Q11/00; A23L1/226 | Oldest priority date: 2003-08-06 | Publication date: 2012-08-09

Score: 8.94598 | Text size: 332611 | Find: similardocuments

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia Pa., ChemDiv of San Diego Calif., Chembridge ofSan Diego Calif.

TETRAHYDROQUINOLINE DERIVATIVES

Nicole CorineRenée Van Straten [NL]; RudolfGijsbertus Van Someren [NL]; Jurgen Schulz[GB];Nicole CorineRenée Van Straten [NL]; RudolfGijsbertus Van Someren [NL]; Jurgen Schulz[GB]

Score: 13.327991 | Text size: 103189 | Find: similardocuments

Collection,order nrs 28020-A0839/0039328 (CAS 310456-97-4) and -A0705/0032919 (CAS327981-38-4);ChemDiv.

TARGETING HUMAN THYMIDYLATE KINASEINDUCES DNA REPAIR TOXICITY IN MALIGNANT TUMOR CELLS

CHANG, Zee-Fen[CN];HU, Chun-Mei[CN];FANG, Jim-Min[CN];YEH, Ming-Tyng[CN];CHANG, Zee-Fen[CN];HU, Chun-Mei[CN];FANG, Jim-Min[CN];YEH, Ming-Tyng[CN]

Publicationdate: 2012-06-07 | Patent publication No.: WO-2012072019-A1|Assignees: CHANG, Zee-Fen [CN]; HU, Chun-Mei [CN]; FANG, Jim-Min [CN]; YEH, Ming-Tyng[CN] |IPC: A61K31/425; A61K31/403; C07D513/04; A61P35/00 | Oldest priority date: 2010-11-29 | Publication date: 2012-06-07

Score: 10.928354 | Text size: 200298 | Find: similardocuments

2010) wasmodified and used to screen 21 , 120 structurally diversified compoundsselected from ChemDivlibrary (San Deigo, USA).

PROTEASOME INHIBITORS HAVING CHYMOTRYPSIN-LIKE ACTIVITY

HarshaniLawrence [US]; Yiyu Ge [US]; Said M. Sebti[US];Wayne Guida [US]; HarshaniLawrence [US]; Yiyu Ge [US]; Said M. Sebti[US];Wayne Guida [US]

Publicationdate: 2012-06-07 | Patent publication No.: US-20120142917-A1|Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc. [US]; UNIVERSITYOF SOUTH FLORIDA [US] | IPC: C07D333/34; C07D409/12; C07D413/12; C07C323/67; C07C311/20 | Oldest priority date: 2009-03-06 | Publication date: 2012-06-07

Score: 16.234026 | Text size: 132107 | Find: similardocuments

Theinvention includes a small molecule HLM-008182, identified from 20,000in-house ChemDiv library, was confirmed by in-house synthesisas a proteasome chymotrypsin-like inhibitor. ... proteasome inhibitors,HLM-008182 (1) (FIG. 2) was identified as a ‘hit’ from a 20,000 in-house ChemDiv librarythat shows potent inhibition against chymotrypsin-like proteasome activity withan IC50

SCREENING METHODS FOR IDENTIFYING PLASMODIUM PROTEASES INHIBITORS

BARALE,Jean-Christophe [FR]; BOUILLON,Anthony [FR]; GIGANTI, David[FR];GORGETTE ,Olivier, Louis, Gabriel [FR]; STOVEN,Véronique [FR];NILGES , Michael[FR];PUIJALON , Odile[FR];BARALE,Jean-Christophe [FR]; BOUILLON,Anthony [FR]; GIGANTI, David[FR];GORGETTE ,Olivier, Louis, Gabriel [FR]; STOVEN,Véronique [FR]; NILGES , Michael[FR];PUIJALON , Odile[FR]

Score: 13.793969 | Text size: 88097 | Find: similardocuments

database Thevirtual screening was performed using the commercially available compoundsfrom Chemdiv, Inc (www.chemdiv.com). The Chemdiv moleculeswere filtered using the program Filter (www.openeye.

INHIBITORS OF APURINIC/APYRIMIDINIC ENDONUCLEASE 1 (APE1) AND THEIR USE

MADHUSUDAN,Srinivasan [GB]; FISCHER, Peter[GB];LAUGHTON,Charles [GB]; MADHUSUDAN,Srinivasan [GB]; FISCHER, Peter[GB];LAUGHTON,Charles [GB]

Publicationdate: 2012-06-07 | Patent publication No.: WO-2012073041-A2|Assignees: THE UNIVERSITY OF NOTTINGHAM [GB] | IPC:C07D209/42; C07D235/28; C07D249/10; C07D263/16; C07D277/82; C07D333/66;C07D403/12; C07D405/12; C07D409/12; C07D413/14; C07D417/06; C07D471/04;C07D491/056; C07D263/57; C07C50/00 | Oldestpriority date: 2010-12-02 | Publication date: 2012-06-07

Score: 14.831028 | Text size: 51654 | Find: similardocuments

GERMANY),Enamine Ltd (Kiev, Ukraine), Specs Chemicals (Delft, Netherlands), ChemDivInc. (CA, USA), Ukrorgsynthesis Ltd (Kiev, Ukraine) and Sigma-Aldrich.

USE OF KINESIN INHIBITORS IN HIV INFECTION TREATMENT AND A METHOD FORSCREENING THEM

BENAROCH,Philippe [FR]; GAUDIN,Raphaël [FR]; BENAROCH,Philippe [FR]; GAUDIN,Raphaël [FR]

Publicationdate: 2012-05-31 | Patent publication No.: WO-2012069432-A1|Assignees: INSTITUT CURIE [FR]; INSERM (Institut National de la Santé et de laRecherche Médicale) [FR] | IPC: C12N9/14; C12N15/113; A61K31/7105; C12N15/62; A61P31/18; C12Q1/34;G01N33/68 |Oldest priority date: 2010-11-22 | Publicationdate: 2012-05-31

Score: 12.685205 | Text size: 135459 | Find: similardocuments

Suitablegroups of compounds would include the Hembridge collection (16000compounds), ChemDivcollection (20000 compounds), and the NCI opencollection (140000 compounds).

DEUTERATED SERINE-THREONINE PROTEIN KINASE MODULATORS

Mustapha HADDACH[US];David M. Ryckman[US];Mustapha HADDACH[US];David M. Ryckman[US]

Publicationdate: 2012-05-24 | Patent publication No.: US-20120129849-A1|Assignees: CYLENE PHARMACEUTICALS, INC. [US] | IPC:A61K31/473; C07D471/04; A61K31/4745; A61K31/519; A61K31/5377; C12N5/02;A61P27/02; A61P37/00; A61P31/00; A61P29/00; A61P25/00; C07D221/12; A61P35/00 | Oldest priority date: 2010-10-22 | Publication date: 2012-05-24

Score: 10.928354 | Text size: 198157 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.

COMPOUNDS USEFUL AS A2A RECEPTOR INHIBITORS

MASON, JonathanStephen [GB]; ANDREWS, StephenPhilippe [GB]; CONGREVE, MilesStuart [GB];MASON, JonathanStephen [GB]; ANDREWS, StephenPhilippe [GB]; CONGREVE, MilesStuart [GB]

Score: 15.906768 | Text size: 149786 | Find: similardocuments

available(e.g. from Interbioscreen, Otava, Biofocus DPI, Princeton Biomolecular ResearchInc or ChemDiv Inc). General Procedures Commercial reagents wereutilized without further purification. ... were obtained from Interbioscreen,Otava, Biofocus DPI, Princeton Biomolecular Research Inc or ChemDiv Inc:(i){[5-methyl-3-(4-methyl-1,3-thiazol-2-yl)-4-oxo-4/-/-chromen-7-yl]oxy}acetic acid; (ii)

Use of kinesin inhibitors in HIV infection treatment and a method forscreening them

The designationof the inventor has not yet been filed

Publicationdate: 2012-05-23 | Patent publication No.: EP-2455456-A1|Assignees: Institut Curie [FR] | IPC: C12N9/14; C12N15/113; A61K31/7105; C12N15/62; A61P31/18; C12Q1/34;G01N33/68 | Oldestpriority date: 2010-11-22 | Publication date: 2012-05-23

Score: 12.892465 | Text size: 120572 | Find: similardocuments

Suitablegroups of compounds would include the Hembridge collection (16000compounds), ChemDivcollection (20000 compounds), and the NCl opencollection (140000 compounds).

External link

Compositions and Methods for the Diagnosis and Treatment of InflammatoryDisorders and Fibrotic Disease

Stephen I.Rennard [US]; Tadashi Sato[US];Xiang-der Liu[US];Olaf Holz [DE]; Helgo Magnussen[DE];Stephen I.Rennard [US]; Tadashi Sato[US];Xiang-der Liu[US];Olaf Holz [DE]; Helgo Magnussen[DE]

Publicationdate: 2012-05-17 | Patent publication No.: US-20120121697-A1|Assignees: Stephen I. Rennard [US]; Tadashi Sato [US]; Xiang-der Liu [US]; Olaf Holz[DE]; Helgo Magnussen [DE] | IPC: A61K31/7105; A61K9/133; C40B30/04; A61P11/00; C12N5/02; A61K9/127; C12Q1/68|Oldest priority date: 2009-06-24 | Publication date: 2012-05-17

Score: 11.569273 | Text size: 162920 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

STRUCTURE OF THE C-TERMINAL REGION OF THE INSULIN RECEPTOR a-CHAIN AND OFTHE INSULIN-LIKE GROWTH FACTOR RECEPTOR a-CHAIN

Michael ColinLawrence [AU]; Brian John Smith[AU];John GerbrandtTasman Menting [AU]; Colin WesleyWard [AU];Michael ColinLawrence [AU];Brian John Smith[AU];John GerbrandtTasman Menting [AU]; Colin WesleyWard [AU]

Publicationdate: 2012-05-17 | Patent publication No.: US-20120122771-A1|Assignees: Michael Colin Lawrence [AU]; Brian John Smith [AU]; John Gerbrandt TasmanMenting [AU]; Colin Wesley Ward [AU] | IPC: A61K38/10; C07K1/107; C07K7/08; C12N15/12; G06F19/00; A61P3/10; A61P9/10;A61P19/10; A61P35/00; A61P25/28; G01N33/53; A61P3/04 | Oldest priority date: 2009-04-22 | Publication date: 2012-05-17

Score: 11.569273 | Text size: 198055 | Find: similardocuments

from, forexample, Maybridge Chemical Co. (Tintagel, Cornwall; UK), AMRI (Budapest,Hungary) and ChemDiv(San Diego, Calif.), Specs (Delft, TheNetherlands).

DEFENSIN-LIKE MOLECULES AS NOVEL ANTIMICROBIAL AGENTS

DE LEEUW, Erik[US];MACKERELL, Jr.,Alexander [US]; DE LEEUW, Erik[US];MACKERELL, Jr.,Alexander [US]

Publicationdate: 2012-05-10 | Patent publication No.: WO-2012061767-A2|Assignees: UNIVERSITY OF MARYLAND, BALTIMORE [US] | IPC:A61K31/428; A61K31/404; A61K31/351; A61P31/04; A61P31/00 | Oldest priority date: 2010-11-04 | Publication date: 2012-05-10

Score: 19.160593 | Text size: 64554 | Find: similardocuments

1. [0021]FIG. 11 depicts chemical structures, ID number, Molecular Weight and ChemicalFormula of ChemDivCorporation compounds tested for possible usewith the present methods. [0022] FIG. ... databases, Maybridge (Thermo FisherScientific Inc., Wattham, MA), ChemBridge (San Diego, CA), and ChemDiv (SanDiego, CA), containing 59676, 482276, and 533143 compounds, respectively,identified -100 ... 6 compounds based on side-chain similiarity, 13 compoundsbased on whole-chain similarity [00100] ChemDiv: 5 compounds basedon side-chain similarity, 8 compounds based on whole-chain similarity ... FIG.11 depicts the Chemical structures, ID number, Molecular Weight and ChemicalFormula of ChemDiv Corporation compounds. [00108] FIG.

Hedgehog Pathway Antagonists and Methods of Use

James K. Chen[US];Joel M. Hyman[US];Cory A. Ocasio[IE];James K. Chen[US];Joel M. Hyman[US];Cory A. Ocasio[IE]

Publicationdate: 2012-05-03 | Patent publication No.: US-20120108630-A1|Assignees: The Board of Trustees of the Leland Stanford Junior University [US] | IPC: A61K31/47;C07D215/54; B65D85/00; C12N5/02 | Oldestpriority date: 2008-02-12 | Publication date: 2012-05-03

Score: 14.999643 | Text size: 176053 | Find: similardocuments

Smallmolecules HPI-1 through HPI-4 were purchased from ChemDiv, Spec,Chembridge, or Ambinter. ... screen and dose-response studies, additionalquantities of HPI-1 through HPI-4 were purchased fromChemDiv, Specs,Chembridge, or Abminter and their chemical compositions were verified by massspectrometry.

RECEPTOR ACTIVATOR OF THE RANK RECEPTOR COMPLEX INHIBITOR

RamachandranMurali [US];Mark I. Greene[US];RamachandranMurali [US];Mark I. Greene[US]

Publicationdate: 2012-05-03 | Patent publication No.: US-20120108559-A1|Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US] | IPC: A61K31/585;C07J17/00; A61P19/08 | Oldestpriority date: 2009-01-14 | Publication date: 2012-05-03

Score: 15.56228 | Text size: 22312 | Find: similardocuments

The compoundof Formula III-1 was obtained from ChemDiv.

Compounds and Methods for Treating Mammalian Gastrointestinal MicrobialInfections

Lizbeth K. Hedstrom[US];Gregory D. Cuny[US];Deviprasad R.Gollapalli [US]; SivapriyaKirubakaran [IN]; Sushil KumarMaurya [GB];Boris Striepen[US];Suresh KumarGorla [US];Corey RobertJohnson [US]; MandapatiKavitha [US]; Jihan Khan [US]; Lizbeth K.Hedstrom [US]; Gregory D. Cuny[US];Deviprasad R.Gollapalli [US]; SivapriyaKirubakaran [IN]; Sushil KumarMaurya [GB];Boris Striepen[US];Suresh KumarGorla [US];Corey RobertJohnson [US]; MandapatiKavitha [US]; Jihan Khan [US]

Publicationdate: 2012-04-26 | Patent publication No.: US-20120101096-A1|Assignees: University of Georgia Foundation, Inc. [US]; Brandeis University [US] | IPC: A61K31/535 | Oldest priority date: 2009-03-20 | Publication date: 2012-04-26

Score: 10.354719 | Text size: 237353 | Find: similardocuments

Compounds D,E, F, G, and H were purchased from ChemDiv Inc. (San Diego,Calif.), Compounds A, B and C were synthesized as described previously.

Compounds Having Activity in Increasing Ion Transport by Mutant-CFTR andUses Thereof

Alan Verkman[US];R. Kiplin Guy[US];NicolettaPedemonte [US]; Luis J.V.Galietta [IT]; Alan Verkman[US];R. Kiplin Guy[US];NicolettaPedemonte [US]; Luis J.V.Galietta [IT]

Publicationdate: 2012-04-26 | Patent publication No.: US-20120101143-A1|Assignees: Alan Verkman [US]; R. Kiplin Guy [US]; Nicoletta Pedemonte [US]; Luis J.V.Galietta [IT] | IPC: A61K31/405; A61P43/00; C12N5/071; A61K31/357 | Oldest priority date: 2004-06-04 |Publicationdate: 2012-04-26

Score: 12.290053 | Text size: 145321 | Find: similardocuments

Foroptimization, compounds identified in the primary screen were purchasedfrom ChemDiv (out of ̃600,000 available compounds).Compounds were prepared as 10 mM stock solutions in DMSO.

STRUCTURE-GUIDED IDENTIFICATION OF BINDING INTERACTIONS OF HUMAN LAMININRECEPTOR PRECURSOR WITH LAMININ AND IDENTIFICATION OF COMPOUNDS THAT AFFECTBINDING

MERUELO, Daniel[US];JAMIESON, Kelly[US];DIGIACOMO,Vincent [US]; MERUELO, Daniel[US];JAMIESON, Kelly[US];DIGIACOMO,Vincent [US]

Publicationdate: 2012-04-26 | Patent publication No.: WO-2012054739-A2|Assignees: NEW YORK UNIVERSITY [US] | IPC: A61K31/4995; A61K31/498; A61K31/495; A61K31/5375; A61P25/28; A61P25/00 | Oldest priority date: 2010-10-21 | Publication date: 2012-04-26

Score: 14.165414 | Text size: 77240 | Find: similardocuments

which werediscovered by searching databases of publically available chemicals(ChemBridge, ChemDiv, Enamine and PubChem), interacted with thereceptor in a similar manner when virtually docked to

DEUTERATED SERINE-THREONINE PROTEIN KINASE MODULATORS

HADDACH,Mustapha [US]; RYCKMAN, DavidM. [US];HADDACH,Mustapha [US]; RYCKMAN, DavidM. [US]

Score: 11.239684 | Text size: 200081 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston- Salem, NC), ChemBridge (SanDiego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, TheNetherlands), Timtec (Newark, DE), or alternatively can be

POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATEDPATHOLOGIES

WINSSINGER,Nicolas [FR]; BARLUENGA, Sofia[FR];WINSSINGER,Nicolas [FR]; BARLUENGA, Sofia[FR]

Publicationdate: 2012-04-26 | Patent publication No.: WO-2012052843-A1|Assignees: UNIVERSITE DE STRASBOURG [FR]; LE CENTRE NATIONAL DE LA RECHERCHESCIENTIFIQUE [FR] | IPC: C07D313/00; C07D495/04; C07H15/26; A61K31/335; A61K31/7048; A61P35/00 | Oldest priority date: 2010-10-22 | Publication date: 2012-04-26

Score: 11.918776 | Text size: 204210 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (SanDiego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, TheNetherlands), Timtec (Newark, DE), or alternatively can be

DETECTING AND TREATING BREAST CANCER RESISTANCE TO EGFR INHIBITORS

Roland Meier[CH];Sun-YoungMoonlee [KR]; Paraic A. Kenny[US];Mina J. Bissell[US];Saori Furuta[US];Roland Meier[CH];Sun-YoungMoonlee [KR]; Paraic A. Kenny[US];Mina J. Bissell[US];Saori Furuta[US]

Publicationdate: 2012-04-19 | Patent publication No.: US-20120094843-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: C40B30/06;C12Q1/02; G01N21/64; C40B20/00; G01N33/566 | Oldest priority date: 2009-04-01 | Publication date: 2012-04-19

Score: 16.189404 | Text size: 202109 | Find: similardocuments

molecules,such as beta-turn mimetic libraries and the like, may be purchased from forexample ChemDiv, Pharmacopia or Combichem or synthesized and aredescribed in Tietze and Lieb, Curr. Opin. Chem. ... For example, ChemDiv usesmore than 800 individual chemical cores, a unique Building Block Library, andproprietary ... In addition, ChemDiv's compounds are designed toensure their similarity to drugs adjusted according to proprietary

COMPOSITIONS AND METHODS USEFUL FOR THE TREATMENT AND DIAGNOSIS OFINFLAMMATORY BOWEL DISEASE

FRIEDMAN,Joshua, R. [US]; ZAHM, Adam [US]; THAYU, Meena[US];FRIEDMAN,Joshua, R. [US]; ZAHM, Adam [US]; THAYU, Meena[US]

Score: 14.039395 | Text size: 93935 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia),

Paramyxovirus family inhibitors andmethods of use thereof

Plemper, RichardK [US];Snyder, James P[US];Sun, Aiming [US]

Score: 12.892465 | Text size: 119928 | Find: similardocuments

The compoundlibrary used is a diversity set from ChemDiv (San Diego, CA).Example 3 Chemical synthesis of compound 16677.

External link

Flavors, flavor modifiers, tastants, taste enhancers, umami or sweettastants, and/or enhancers and use thereof

CatherineTachdjian [US]; Andrew P. Patron[US];Sara L.Adamski-Werner [US]; Farid Bakir [US]; Qing Chen [US]; VincentDarmohusodo [US];Stephen TerrenceHobson [US];Xiaodong Li [US]; Ming Qi [CN]; Daniel H. Rogers[US];Marketa Rinnova[US];Guy Servant [US]; Xiao-Qing Tang[US];Mark Zoller [US]; David Wallace[US];Amy Xing [US]; Klaus Gubernator[US];CatherineTachdjian [US]; Andrew P. Patron[US];Sara L.Adamski-Werner [US]; Farid Bakir [US]; Qing Chen [US]; VincentDarmohusodo [US]; Stephen TerrenceHobson [US];Xiaodong Li [US]; Ming Qi [CN]; Daniel H. Rogers[US];Marketa Rinnova[US];Guy Servant [US]; Xiao-Qing Tang[US];Mark Zoller [US]; David Wallace[US];Amy Xing [US];Klaus Gubernator[US]

Score: 8.94598 | Text size: 343481 | Find: similardocuments

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia Pa., ChemDiv of San Diego Calif., Chembridge ofSan Diego Calif.

LIPID CONTAINING FORMULATIONS

MuthiahMANOHARAN [US]; KallanthottathilG. Rajeev [US]; Akin Akinc [US]; Narayanannair K.Jayaprakash [US]; MuthusamyJayraman [US]; Martin Maier[US];MuthiahMANOHARAN [US]; KallanthottathilG. Rajeev [US]; Akin Akinc [US]; Narayanannair K.Jayaprakash [US]; MuthusamyJayraman [US]; Martin Maier[US]

Score: 9.838301 | Text size: 321525 | Find: similar documents

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, SanDiego, Calif.

Hedgehog pathway antagonists methods of use

James K. Chen[US];Joel M. Hyman[US];Cory A. Ocasio[US];James K. Chen[US];Joel M. Hyman[US];Cory A. Ocasio[US]

Score: 15.290299 | Text size: 151370 | Find: similardocuments

METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITIONCONTAINING STABILIZED SWEET ENHANCER

Catherine TACHDJIAN[US];Donald S.Karanewsky [US]; Xiao-Qing Tang[US];Hanghui Liu [US]; CatherineTACHDJIAN [US]; Donald S.Karanewsky [US]; Xiao-Qing Tang[US];Hanghui Liu [US]

Score: 8.202065 | Text size: 473844 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITIONCONTAINING STABILIZED SWEET ENHANCER

TACHDJIAN,Catherine [US]; KARANEWSKY,Donald S. [US]; TANG, Xiao-Qing[US];LIU, Hanghui[US];TACHDJIAN,Catherine [US]; KARANEWSKY,Donald S. [US]; TANG, Xiao-Qing[US];LIU, Hanghui[US]

Score: 8.94598 | Text size: 480208 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, PA, ChemDiv of San Diego, CA, Chembridge of SanDiego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the

SMALL MOLECULES THAT REPLACE OR AGONIZE P53 FUNCTION

ShahroozRabizadeh [US]; Kayvan Niazi[US];Dale E. Bredesen[US];ShahroozRabizadeh [US]; Kayvan Niazi[US];Dale E. Bredesen[US]

Publicationdate: 2012-02-16 | Patent publication No.: US-20120040457-A1|Assignees: Shahrooz Rabizadeh [US]; Kayvan Niazi [US]; Dale E. Bredesen [US] | IPC: C12N5/10;C40B30/06 | Oldestpriority date: 2004-08-20 | Publication date: 2012-02-16

Score: 18.607246 | Text size: 44557 | Find: similardocuments

Subunit Selective NMDA Receptor Potentiators For The Treatment OfNeurological Conditions

Stephen F.Traynelis [US]; Dennis C. Liotta[US];Rose M.Santangelo [US]; Ethel C. Garnier[US];Stephen F.Traynelis [US]; Dennis C. Liotta[US];Rose M.Santangelo [US]; Ethel C. Garnier[US]

Publicationdate: 2012-02-02 | Patent publication No.: US-20120028977-A1|Assignees: EMORY UNIVERSITY [US] | IPC: A61K31/472; C07D405/06; C07D413/06; C07D491/056; C07D239/56; C07D233/42;C07D333/68; C07D409/12; C07D333/38; C07D213/75; C07D261/14; C07C229/38;A61K31/4725; A61K31/5377; A61K31/4741; A61P25/18; A61P25/16; A61P25/24;A61P25/22; A61P25/00; A61P25/28; A61P25/08; A61P25/14; A61P29/00; A61P19/08;A61P19/10; A61P35/00; C07D217/16 | Oldestpriority date: 2009-01-28 | Publication date: 2012-02-02

Score: 16.644737 | Text size: 181804 | Find: similardocuments

ROS1 KINASE INHIBITORS FOR THE TREATMENT OF GLIOBLASTOMA AND OTHERP53-DEFICIENT CANCERS

GRUENEBERG,Dorre [US];HARLOW, Ed [US]; XIAN, Jun [US]; GRUENEBERG,Dorre [US];HARLOW, Ed [US]; XIAN, Jun [US]

Publicationdate: 2012-02-02 | Patent publication No.: WO-2012016133-A2|Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: A61K31/428;A61K31/5517; A61K31/437; A61K31/519; A61K31/495; A61K31/4196; A61K31/4985;A61P35/00 | Oldestpriority date:2010-07-29 | Publication date: 2012-02-02

Score: 13.10661 | Text size: 104374 | Find: similardocuments

Approximately50,000 compounds in a publicly available compound library (ChemDiv (SanDiego, Califorina)) compound library were used to screen for ROSl inhibitors.

Method of modulating human ENaC sodium channel

Guy Servant [US]; Hong Chang [US]; Cyril Redcrow[US];Sumita Ray [US]; Imran Clark [US]; Bryan Moyer [US]; Guy Servant [US]; Hong Chang [US]; Cyril Redcrow[US];Sumita Ray [US]; Imran Clark [US]; Bryan Moyer [US]

Score: 12.484504 | Text size: 151917 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

ANTIBACTERIAL COMPOUNDS

Paul James Davis[GB];Olivier De Moor[GB];Colin RichardDorgan [GB];Peter DavidJohnson [GB]; Alan GeoffreyRoach [GB];Richard Storer[GB];Richard JohnVickers [GB]; Francis XavierWilson [GB];Graham MichaelWynne [GB];Paul James Davis[GB];Olivier De Moor[GB];Colin RichardDorgan [GB];Peter David Johnson[GB];Alan GeoffreyRoach [GB];Richard Storer[GB];Richard JohnVickers [GB]; Francis XavierWilson [GB];Graham MichaelWynne [GB]

Publicationdate: 2012-01-26 | Patent publication No.: US-20120020950-A1|Assignees: SUMMIT CORPORATION PLC | IPC: A61K31/4184; C07D401/14; A61K31/444; A61K35/74; A61K39/40; A61P31/04;A01P1/00; A01N43/52; A01N43/40; A61K38/12; C07D403/10; A01N63/02 |Oldestpriority date: 2008-12-02 | Publication date: 2012-01-26

Score: 12.484504 | Text size: 129434 | Find: similardocuments

Vol. 26, No2, January 2006]. (ii) Commercial Compounds All compounds below were purchasedfromChemDiv:3,3′-(1H,1′H-5,5′-Bibenzo[d]imidazole-2,2′-diyl)dianiline(Compound 2).

PRO-NEUROGENIC COMPOUNDS

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]; Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. De Brabander[US]

Publicationdate: 2012-01-26 | Patent publication No.: US-20120022096-A1|Assignees: Board of Regents of The University of Texas System [US] | IPC: A61K31/437;C07D263/22; C07D471/04; A61K31/403; A61P25/02; A61P25/28; A61P25/08; A61P25/16;A61P25/22; A61P25/24; C07D209/56; A61K31/421 | Oldest priority date: 2009-01-09 | Publication date: 2012-01-26

Score: 18.14778 | Text size: 587471 | Find: similardocuments

compound canbe purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00132]] This compound can be purchased from ChemDiv, Inc.Example61 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00133]] This compound can be purchased from ChemDiv, Inc. Example62 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00134]] This compound can be purchased from ChemDiv, Inc. Example63 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00135]] This compound can be purchased from ChemDiv, Inc. Example

Neurofibromin pathway modulators

David Gutmann[US];Jason Weber [US]; David Gutmann[US];Jason Weber [US]

Score: 16.575033 | Text size: 76686 | Find: similardocuments

may be theNCI Structural Diversity Sets, Versions 1 or 2, the NCI Open Collection 1 orthe ChemDiv Combilab or International Collections from theNCI. ... Additional libraries from the NCI, such as the ChemDiv Combilaband International Collection, are available.

Pyrrolinone derivative and pharmaceutical composition comprising the same

Hiroyuki Kai[JP];Shunji Shinohara[JP];TakayukiKameyama [JP]; Hiroyuki Kai[JP];Shunji Shinohara[JP];TakayukiKameyama [JP]

Score: 20.881268 | Text size: 381872 | Find: similardocuments

IFLABF0907-1024 432 I-119 [[image:EMI-C00179]] IFLAB F0908-5466 429 I-120[[image:EMI-C00180]]ChemDiv C390-0148 429 I-121[[image:EMI-C00181]] ChemDiv C390-0158 426 I-122[[image:EMI-C00182]]ChemDiv C390-0130 399 I-123[[image:EMI-C00183]] ChemDiv C390-0241 364 I-124[[image:EMI-C00184]]ChemDiv C390-0577 350 I-125[[image:EMI-C00185]] ChemDiv C390-0573 346 I-126[[image:EMI-C00186]]ChemDiv C390-0587 332 I-127[[image:EMI-C00187]] ChemDiv C390-0571 324 I-128[[image:EMI-C00188]]ChemDiv C390-0605 324 I-129[[image:EMI-C00189]] ChemDiv C390-0540 310 I-130[[image:EMI-C00190]]ChemDiv C390-0594 306 I-131[[image:EMI-C00191]] ChemDiv C390-0569 304 I-132[[image:EMI-C00192]]ChemDiv C390-0545 304 I-133[[image:EMI-C00193]] CSC D500050981 297 I-134 [[image:EMI-C00194]]ChemDiv C390-0565

PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS

Philippe Nakache[IL];Nurit Livnah[IL];Philippe Nakache[IL];Nurit Livnah[IL]

Publicationdate: 2012-01-19 | Patent publication No.: US-20120015967-A1|Assignees: PROTEOLOGICS, LTD. [IL] | IPC: A61K31/505; A61K31/44; A61P31/12; A61P31/14; A61P25/24; A61P31/20;A61P25/00; A61P25/28; A61P25/16; A61P25/18; C07D213/76; A61P31/18 | Oldest priority date: 2007-08-22 | Publication date: 2012-01-19

Score: 12.290053 | Text size: 125644 | Find: similardocuments

Moscow,Russia; ChemDiv, San Diego USA) was then cherry-picked, collectedand then screened for their effect on

NOVEL PYRROLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISINGTHE SAME

Hiroyuki Kai[JP];Shunji Shinohara[JP];TakayukiKameyama [JP]; Hiroyuki Kai[JP];Shunji Shinohara[JP];TakayukiKameyama [JP]

Publicationdate: 2012-01-12 | Patent publication No.: US-20120010199-A1|Assignees: Hiroyuki Kai [JP]; Shunji Shinohara [JP]; Takayuki Kameyama [JP] | IPC: A61K31/422;C07D413/14; A61P25/00; A61K31/454; C07D487/04; A61K31/551; C07D413/10;A61K31/4439 | Oldestpriority date: 2007-03-30 | Publication date: 2012-01-12

Score: 20.863457 | Text size: 427673 | Find: similardocuments

IFLABF0907-1024 432 I-119 [[image:EMI-C00179]] IFLAB F0908-5466 429 I-120 [[image:EMI-C00180]]ChemDiv C390-0148429 I-121 [[image:EMI-C00181]] ChemDiv C390-0158 426 I-122[[image:EMI-C00182]]ChemDiv C390-0130 399 I-123[[image:EMI-C00183]] ChemDiv C390-0241 364 I-124[[image:EMI-C00184]]ChemDiv C390-0577 350 I-125 [[image:EMI-C00185]] ChemDiv C390-0573346 I-126 [[image:EMI-C00186]]ChemDiv C390-0587 332 I-127[[image:EMI-C00187]] ChemDiv C390-0571 324 I-128[[image:EMI-C00188]]ChemDiv C390-0605 324 I-129[[image:EMI-C00189]] ChemDiv C390-0540 310 I-130[[image:EMI-C00190]]ChemDiv C390-0594 306 I-131[[image:EMI-C00191]] ChemDiv C390-0569 304 I-132[[image:EMI-C00192]]ChemDiv C390-0545 304 I-133[[image:EMI-C00193]] CSC D50050981 297 I-134 [[image:EMI-C00194]]ChemDiv C390-0565

PRO-NEUROGENIC COMPOUNDS

MCKNIGHT, StevenL. [US];PIEPER, AndrewA. [US];READY, Joseph M.[US];DE BRABANDER,Jef K. [US];MCKNIGHT, StevenL. [US];PIEPER, AndrewA. [US];READY, Joseph M.[US];DE BRABANDER,Jef K. [US]

Publicationdate: 2012-01-12 | Patent publication No.: WO-2012006419-A2|Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US] | IPC: A01N43/38;A61K31/40; A61K31/405 | Oldestpriority date: 2010-07-07 | Publication date: 2012-01-12

Score: 18.300833 | Text size: 590194 | Find: similardocuments

[[image:imgf000166_0003]]This compound can be purchased from ChemDiv, Inc. Example 58.l-(2-chlorophenylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol[[image:imgf000166_0004]] This compound can be purchased from ChemDiv,Inc. Example 59. l-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol[[image:imgf000167_0001]] This compound can be purchased from ChemDiv,Inc. Example 60.l-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:imgf000167_0002]] This compound can be purchased from ChemDiv,Inc. Example 61.l-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:imgf000167_0003]] This compound can be purchased fromChemDiv, Inc. Example62.

TREATMENT OF ABNORMALITIES OF GLUCOSE METABOLISM WITH AN ANTAGONIST OFINHIBITOR OF DIFFERENTIATION 1

ACKERFELDT, Mia[AU];LAYBUTT, Ross[AU];ACKERFELDT, Mia[AU];LAYBUTT, Ross[AU]

Publicationdate: 2012-01-05 | Patent publication No.: WO-2012000036-A1|Assignees: GARVAN INSTITUTE OF MEDICAL RESEARCH [AU] |IPC: A61K31/381; A61K31/17; A61P3/08; A61K31/165; A61K31/36; A61P3/10 | Oldest priority date: 2010-06-30 | Publication date: 2012-01-05

Score: 16.068731 | Text size: 116854 | Find: similardocuments

Forexample, Chemdiv Inc produces l-(4-methoxybenzyl)-4-(2,4,5-trimethoxybenzyl)piperazine;N'- ... 11- oxodibenzo[b,fj[l,4]thiazepin-10(l lH)-yl]acetamide from ChemdivInc. Ethyl 1 -(3-[(2,5-dimethyloxyphenyl)amino]-3-oxopropyl)-4-piperidinecarboxylate hydrochloride;

PHENYLALANINE DERIVATIVES AND THEIR USE AS NON-PEPTIDE GLP-1 RECEPTORMODULATORS

Jiayu LIAO [US]; Yufeng Hong [US]; Yong Wang [US]; Thomas W. VonGeldern [US]; Kanyin E. Zhang[US];Jiayu LIAO [US]; Yufeng Hong [US]; Yong Wang [US]; Thomas W. VonGeldern [US]; Kanyin E. Zhang[US]

Publicationdate: 2012-01-05 | Patent publication No.: US-20120004198-A1|Assignees: ARGUSINA INC. [US] | IPC: A61K31/635; C07C271/28; C07D271/06; C07D413/12; C07D413/14; A61K31/341;A61K31/27; A61K31/4245; A61K31/4439; A61K31/506; A61K31/454; A61K31/5377;A61K31/551; C12N5/071; A61P3/04; A61P3/00; A61P3/10; A61P3/06; A61P9/00;C07D307/68 | Oldestpriority date: 2010-02-02 | Publication date: 2012-01-05

Score: 10.089907 | Text size: 293550 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

William Welsh[US];Ching Y. Wang[US];Ni Ai [US]; William Welsh[US];Ching Y. Wang[US];Ni Ai [US]

Publicationdate: 2011-12-29 | Patent publication No.: US-20110319465-A1|Assignees: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY [US] | IPC: A61K31/4035;C07D209/48; A61K31/122; A61P19/10; A61P9/10; G01N33/566; A61P43/00; A61P13/08;A61P7/00; A61P15/00; A61P17/00; A61P25/28; C07C49/753; A61P35/00 | Oldest priority date: 2006-07-06 | Publication date: 2011-12-29

Score: 17.397278 | Text size: 48869 | Find: similardocuments

METHODS FOR PRODUCINGENTEROENDOCRINE CELLS THAT MAKE AND SECRETE INSULIN

TALCHAI, Chutima[US];ACCILI, Domenico[US];TALCHAI, Chutima[US];ACCILI, Domenico[US]

Score: 11.239684 | Text size: 187803 | Find: similardocuments

Increasing lifespan by modulation of WWP-1 and UBC-18

Andrea C.Carrano [US]; Andrew Dillin[US];Tony Hunter [US]; Andrea C.Carrano [US]; Andrew Dillin[US];Tony Hunter [US]

Publicationdate: 2011-11-15 | Patent publication No.: US-08058502-B2|Assignees: The Salk Institute for Biological Studies [US] | IPC:G01N33/00; A01K67/00; C12P21/06; C12N5/00; C07H21/04; C07K1/00 | Oldest priority date: 2007-08-17 | Publication date: 2011-11-15

Score: 10.928354 | Text size: 271021 | Find: similardocuments

(San Diego,Calif.) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, Calif.

Cystic fibrosis transmembrane conductance regulator protein inhibitorsand uses thereof

Alan Verkman[US];Tonghui Ma [US]; Alan Verkman[US];Tonghui Ma [US]

Score: 12.290053 | Text size: 141923 | Find: similardocuments

Structure-activityanalysis was done on analogs purchased from ChemBridge and ChemDiv (SanDiego, Calif.

Tetrahydroquinoline derivatives

Nicole CorineRenée Van Straten [NL]; RudolfGijsbertus Van Someren [NL]; Jurgen Schulz[GB];Nicole CorineRenée Van Straten [NL]; RudolfGijsbertus Van Someren [NL]; Jurgen Schulz[GB]

Score: 13.327991 | Text size: 114015 | Find: similardocuments

Collection,order nrs 28020-A0839/0039328 (CAS 310456-97-4) and -A0705/0032919 (CAS327981-38-4);ChemDiv.

Oxindole derivative

Noriaki Shinobu[JP];Jun Shao [JP]; MasatakaKobayashi [JP]; Takao Mori [JP]; Noriaki Shinobu[JP];Jun Shao [JP]; MasatakaKobayashi [JP]; Takao Mori [JP]

Score: 14.039395 | Text size: 72938 | Find: similardocuments

compoundswere searched from a serine/threonine kinase inhibitory compound library(available fromChemDiv). Based on the information of correlation ofstructural activity of the obtained candidate

2'-F MODIFIED RNA INTERFERENCE AGENTS

MuthiahManoharan [US]; KallanthottathilG. Rajeev [US]; MuthiahManoharan [US]; KallanthottathilG. Rajeev [US]

Publicationdate: 2011-11-03 | Patent publication No.: US-20110269814-A1|Assignees: ALNYLAM PHARAMACEUTICALS, INC. [US] | IPC:A61K31/713; C07H21/02; C07K16/18; C07K2/00; C07K9/00; C07H1/00; C12N5/071 | Oldest priority date: 2008-03-26 | Publication date:2011-11-03

Score: 7.032474 | Text size: 556546 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, SanDiego, Calif.

SMALL MOLECULE INHIBITORS OF USP1 DEUBIQUITINATING ENZYME ACTIVITY

D'ANDREA, Alan, D. [US]; CUNY, Gregory,D. [US];STEIN, Ross, L.[US];GLICKSMAN,Marcie [US];CASE, April [US]; XIAN, Jun [US]; WILSON, David[US];HUANG, Min [CN]; D'ANDREA, Alan,D. [US];CUNY, Gregory,D. [US];STEIN, Ross, L.[US];GLICKSMAN,Marcie [US];CASE, April [US]; XIAN, Jun [US]; WILSON, David[US];HUANG, Min [CN]

Publicationdate: 2011-11-03 | Patent publication No.: WO-2011137320-A2|Assignees: DANA-FARBER CANCER INSTITUTE, INC. [US]; THE BRIGHAM AND WOMEN'S HOSPITAL,INC. [US] | IPC: A01N43/38; A61K31/40 | Oldestpriority date: 2010-04-30 | Publication date: 2011-11-03

Score: 10.928354 | Text size: 213939 | Find: similardocuments

consists ofknown bioactive libraries, natural product libraries, and commercial librariessuch as ChemDiv, ChemBridge, etc.

Methods of Identifying Functional Characteristics of Promoters,Transcription Modifying Proteins and Transcription Modulating Agents

Johan W. Jonker[NL];Michael Downes[US];Ronald M. Evans[US];Johan W. Jonker[NL];Michael Downes[US];Ronald M. Evans[US]

Score: 8.557886 | Text size: 323027 | Find: similardocuments

(San Diego,Calif.) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, Calif.

MICROSOMAL PROSTAGLANDIN E SYNTASE-1 INHIBITORS

BELLENIE,Benjamin, Richard [GB]; FARRE-GUTIERREZ,Irene [GB];BELLENIE,Benjamin, Richard [GB]; FARRE-GUTIERREZ,Irene [GB]

Publicationdate: 2011-10-27 | Patent publication No.: WO-2011131975-A1|Assignees: CONVERGENCE PHARMACEUTICALS LIMITED [GB] |IPC: A61K31/4525; A61K31/4535; C07D263/58; C07D275/06; A61P29/00 | Oldest priority date: 2010-04-23 | Publication date: 2011-10-27

Score: 18.04004 | Text size: 86065 | Find: similardocuments

-[6-(ethyloxy)-1,3- benzothiazol-2-yl]-3-piperidinecarboxamide are available from ChemDiv,Inc.(http://www.chemdiv.com). ... ChemDiv, Inc.). Examples 11aand 11 b: (3S)-N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-1 -(4,6- dimethyl-1... ChemDiv, Inc.). Biological activity The mPGES-1 assay has beenconfigured as a coupled product detection//'/!

COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OR ELIMINATING BITTERTASTE

SHEKDAR, Kambiz[US];LAVERY, Daniel[US];GUNNET, Joseph[US];LANGER, Jessica[US];LELAND, Jane V.[US];HAYASHI, David[US];BROWN, Peter H.[US];SLADE, Louise[US];JONES, WilliamP. [US];SHEKDAR, Kambiz[US];LAVERY, Daniel[US];GUNNET, Joseph[US];LANGER, Jessica[US];LELAND, Jane V.[US];HAYASHI, David[US];BROWN, Peter H.[US];SLADE, Louise[US];JONES, WilliamP. [US]

Score: 8.94598 | Text size: 337870 | Find: similardocuments

wereobtained from commercial vendors for synthetic and natural compounds, includingVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine, [0385] The

SHP-2 PHOSPHATASE INHIBITOR

Cheng-Kui Qu[US];Wen-Mei Yu [US]; Olgun Guvench[US];Alexander D.Mackerell, JR. [US]; Cheng-Kui Qu[US];Wen-Mei Yu [US]; Olgun Guvench[US];Alexander D.Mackerell, JR. [US]

Publicationdate: 2011-10-20 | Patent publication No.: US-20110257184-A1|Assignees: Cheng-Kui Qu [US]; Wen-Mei Yu [US]; Olgun Guvench [US]; Alexander D.Mackerell, JR. [US] | IPC: A61K31/53; C12N9/99; A61P35/02 | Oldestpriority date: 2009-11-13 | Publication date: 2011-10-20

Score: 13.327991 | Text size: 93211 | Find: similardocuments

chemicallydiverse list of approximately 200 compounds selected via CADD were purchasedfrom ChemDiv(San Diego, Calif.), ChemBridge (San Diego, Calif.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OR ELIMINATING BITTERTASTE

Score: 8.94598 | Text size: 336804 | Find: similardocuments

were obtainedfrom commercial vendors for synthetic and natural compounds, includingVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and Indofine.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING OR ELIMINATING BITTERTASTE

Publicationdate: 2011-10-20 | Patent publication No.: WO-2011130705-A1|Assignees: CHROMOCELL CORPORATION [US]; KRAFT FOODS GLOBAL BRANDS LLC [US] | IPC: A23L1/22;A23L2/56 | Oldestpriority date: 2010-04-15 | Publication date: 2011-10-20

Score: 8.557886 | Text size: 413478 | Find: similardocuments

wereobtained from commercial vendors for synthetic and natural compounds, includingVitasM, ChemDiv, ChemBridge, Chromadex, Sigma Aldrich, Penta,Spectrum Chemical, Vigon, and indofine.

GALACTOKINASE INHIBITORS

Kent Lai [US]; Klass JanWierenga [US]; Manshu Tang [US]; Kent Lai [US]; Klass JanWierenga [US]; Manshu Tang [US]

Publicationdate: 2011-10-13 | Patent publication No.: US-20110251236-A1|Assignees: University of Miami [US] | IPC: A61K31/4709; C07D311/82; C07C323/20; C07D401/04; C07D307/91; A61P3/00;C40B30/00; A61K31/055; A61K31/352; A61K31/10; A61K31/343; C07C39/367;C07D311/92 | Oldestpriority date: 2007-08-15 | Publication date: 2011-10-13

Score: 21.244547 | Text size: 179788 | Find: similardocuments

3553-1484;SPBio—001210 (Hexachlorophene); SMP2—000049 Sigma E9259 (Erythrosin B); ChemDiv3—007133 ChemDiv 7218-1483;TimTec1—001324 TimTec ST014236; ChemDiv3—007089 ChemDiv 7218-1459;Maybridge4—001932 JFD03061; TimTec1—000233 TimTec ST000572;ChemDiv3—014119 ChemDiv7218-1576; ChemDiv3—001694 ChemDiv 3241-0272;SPBio—000126 Spectrum2—000113 (Bithionol); SPBio—001697 Spectrum2—001629(Rhodomyrtoxin); ChemDiv3—002334 ChemDiv 3696-0201;ChemDiv3—000903 ChemDiv 1887-0088; TimTec1—001108 TimTecST014268; Maybridge4—001288 HTS01859; SMP2—000320 Sigma S1014 (Streptonigrin);TimTec1—001055 TimTec ST012305; ChemDiv3—001508 ChemDiv3229-1543;ChemDiv3—007160 ChemDiv 8012-2663; ChemDiv3—001677 ChemDiv 3062-0036;TimTec1—003525 TimTec ST048025; BiomolKI2—000062 BiomolEI-307;ChemDiv3—001693 ChemDiv

Lipid containing formulations

MuthiahManoharan [US]; KallanthottathilG. Rajeev [US]; Akin Akinc [US]; Narayanannair K.Jayaprakash [US]; MuthusamyJayraman [US]; Martin Maier[US];MuthiahManoharan [US]; KallanthottathilG. Rajeev [US]; Akin Akinc [US]; Narayanannair K.Jayaprakash [US]; MuthusamyJayraman [US]; Martin Maier[US]

Score: 10.354719 | Text size: 274423 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, SanDiego, Calif.

ACTIVE SUBSTANCE AND PHARMACEUTICAL COMPOSITION FOR TREATING ALCOHOLDEPENDENCE, AND A METHOD FOR OBTAINING AND THE USE OF SAID ACTIVE SUBSTANCE

AndreyAlexandrovich Ivashchenko [RU]; NikolayFilippovich Savchuk [US]; AndreyAlexandrovich Ivashchenko [RU]; NikolayFilippovich Savchuk [US]

Publicationdate: 2011-10-06 | Patent publication No.: US-20110245231-A1|Assignees: Alla Chem, LLC [US] | IPC: A61K31/554; C07D401/12; A61K31/4439; C07D235/28; A61K31/4184; C07D405/12;C07D409/12; C07D413/12; A61K31/4245; A61K31/5377; A61K31/454; C07D403/12;A61K31/4192; A61K31/496; A61K31/4985; A61P25/24; A61P25/32 | Oldest priority date: 2009-12-15 | Publication date: 2011-10-06

Score: 14.971729 | Text size: 40963 | Find: similardocuments

disorders,treatment of pains WO 2004014881; WO 20050773465 Other commerciallyavailable ChemDiv Inc.[www.chemdiv.

SWEET FLAVOR MODIFIER

TACHDJIAN,Catherine [US]; TANG, Xiao-Qing[US];KARANEWSKY,Donald, S. [US]; SERVANT, Guy[US];LI, Xiaodong[US];ZHANG, Feng [US]; CHEN, Qing [US]; ZHANG, Hong [US]; DAVIS, Timothy[US];DARMOHUSODO,Vincent [US]; WONG, Melissa[US];SELCHAU, Victor[US];TACHDJIAN,Catherine [US]; TANG, Xiao-Qing[US];KARANEWSKY,Donald, S. [US]; SERVANT, Guy[US];LI, Xiaodong[US];ZHANG, Feng [US]; CHEN, Qing [US];ZHANG, Hong [US]; DAVIS, Timothy[US];DARMOHUSODO,Vincent [US]; WONG, Melissa[US];SELCHAU, Victor[US]

Score: 9.838301 | Text size: 307073 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, PA, ChemDiv of San Diego, CA, Chembridge of SanDiego, CA, Asinex of Moscow, Russia, SPECS/BIOSPECS of the

NOVEL GENE TARGETS ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS ANDMETHODS OF USE THEREOF

GITLER, Aaron,D. [US];GITLER, Aaron,D. [US]

Score: 12.892465 | Text size: 127019 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia),

SWEET FLAVOR MODIFIER

CatherineTACHDJIAN [US]; Xiao Qing TANG[US];Donald S.KARANEWSKY [US]; Guy SERVANT [US]; Xiaodong LI [US]; Feng ZHANG [US]; Qing CHEN [US]; Hong ZHANG [US]; Timothy DAVIS[US];VincentDARMOHUSODO [US]; Melissa WONG[US];Victor SELCHAU[US];CatherineTACHDJIAN [US]; Xiao Qing TANG[US];Donald S.KARANEWSKY [US]; Guy SERVANT [US]; Xiaodong LI [US]; Feng ZHANG [US]; Qing CHEN [US];Hong ZHANG [US]; Timothy DAVIS[US];VincentDARMOHUSODO [US]; Melissa WONG[US];Victor SELCHAU[US]

Publicationdate: 2011-10-06 | Patent publication No.: US-20110245353-A1|Assignees: SENOMYS, INC. [US] | IPC: A61K47/22; C07D215/54; C07D471/04; C07D495/04; C07D401/12; C07D405/12;C07D491/048; A23L1/226; A23L1/30; A23L1/302; A23L1/304; A23L1/305 |Oldestpriority date: 2010-04-02 | Publication date: 2011-10-06

Score: 9.838301 | Text size: 307363 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

Genetic Alterations on Chromosomes 21q, 6q and 15q and Methods of UseThereof for the Diagnosis and Treatment of Type I Diabetes

Hakon Hakonarson[US];Struan Grant[US];JonathanBradfield [US]; ConstantinPolychronakos [CA]; Hui-Qi Qu [CA]; Hakon Hakonarson[US];Struan Grant[US];JonathanBradfield [US]; ConstantinPolychronakos [CA]; Hui-Qi Qu [CA]

Publicationdate: 2011-09-29 | Patent publication No.: US-20110236370-A1|Assignees: Hakon Hakonarson [US]; Struan Grant [US]; Jonathan Bradfield [US];Constantin Polychronakos [CA]; Hui-Qi Qu [CA] | IPC: A61K39/395;C12Q1/68; C40B40/06; C07H21/00; A61K38/02; A61K31/7088; A61K31/7105; C12Q1/02;G01N33/53; A61P3/10 | Oldestpriority date: 2008-05-16 | Publication date: 2011-09-29

Score: 13.10661 | Text size: 141213 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

SMALL MOLECULES FOR THE MODULATIONOF MCL-1 AND METHODS OF MODULATIING CELL DEATH, CELL DIVISION, CELL DIFFERENTIATIONAND METHODS OF TREATING DISORDERS

WALENSKY, Loren,D. [US];STEWART,Michelle, L. [US]; COHEN, Nicole[US];WALENSKY, Loren,D. [US];STEWART,Michelle, L. [US]; COHEN, Nicole[US]

Publicationdate: 2011-08-04 | Patent publication No.: WO-2011094708-A2|Assignees: DANA-FARBER CANCER INSTITUTE, INC [US] | IPC:C07C251/20; C07D215/16; C07D249/08; A61K31/41; A61P35/00 | Oldest priority date: 2010-01-29 | Publication date: 2011-08-04

Score: 11.918776 | Text size: 150420 | Find: similardocuments

CellularBiology at Harvard Medical School and employed commercial libraries (Asinex,Chembridge,ChemDiv, Enamine, Life Chemicals, and Maybridge).

NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONSAND METHODS OF TREATMENT OF CANCER

HROMAS, Robert[US];LEITAO, Andrei[US];OPREA, Tudor, I.[US];SKLAR, Larry, A.[US];WILLIAMSON,Elizabeth, A. [US]; WRAY, Justin[US];WANG, Wei [US]; HROMAS, Robert[US];LEITAO, Andrei[US];OPREA, Tudor, I.[US];SKLAR, Larry, A.[US];WILLIAMSON,Elizabeth, A. [US]; WRAY, Justin[US];WANG, Wei [US]

Publicationdate: 2011-08-04 | Patent publication No.: WO-2011094260-A2|Assignees: STC. UNM [US] | IPC: C07D215/233; C07D401/04; C07D401/14; A61K31/47; A61K31/4709; A61P35/00 | Oldest priority date: 2010-01-26 | Publication date: 2011-08-04

Score: 11.569273 | Text size: 158092 | Find: similardocuments

Example 2Metnasc/Intnase Inhibitor ChemDiv 5483-0023 and RelatedStudies Virtually screening for compounds that can dock within the active

INTERFERON-INDUCING COMPOUNDS AND USES THEREOF

GARCIA-SASTRE,Adolfo [US];ORTIGOZA, Mila[US];PALESE, Peter[US];SHAW, Megan [US]; GARCIA-SASTRE,Adolfo [US];ORTIGOZA, Mila[US];PALESE, Peter[US];SHAW, Megan [US]

Score: 17.439129 | Text size: 261697 | Find: similardocuments

Scientific,Mount Pleasant, SC), Chembridge 3 (10,560 Compounds; ChemBridge Corp., SanDiego, CA),ChemDiv 2 (8,560 Compounds; ChemDiv, Inc.,San Diego, CA), ChemDiv 4 (1 ,320 Compounds; ChemDiv,Inc., San Diego, CA), Enamine 2 (26,576 Compounds; ΕΝΑΜΓΝΕ Ltd. ...Compounds; Maybridge Ltd., Trevillett, England), Mixed Commercial Plate 5 (268Compounds from ChemDiv and Maybridge libraries), Peakdale 2(352 Compounds; Peakdale Molecular Ltd.

TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX

LoriEmert-Sedlak [US]; Toshiaki Kodama[US];Billy W. Day[US];Weixiang Dai[US];Ronald P. Trible[US];Thomas E.Smithgall [US]; LoriEmert-Sedlak [US]; Toshiaki Kodama[US];Billy W. Day[US];Weixiang Dai[US];Ronald P. Trible[US];Thomas E.Smithgall [US]

Publicationdate: 2011-08-04 | Patent publication No.: US-20110190241-A1|Assignees: Lori Emert-Sedlak [US]; Toshiaki Kodama [US]; Billy W. Day [US]; WeixiangDai [US]; Ronald P. Trible [US]; Thomas E. Smithgall [US] | IPC: A61K31/635;C07D241/44; C07D405/12; C07D491/048; A61K31/498; A61K31/519; A61K31/5377;A61P31/18 | Oldestpriority date: 2008-05-14 | Publication date: 2011-08-04

Score: 18.761955 | Text size: 96510 | Find: similardocuments

Carlsbad,Calif.) as described by Trible et al. (Id.) Chemical libraries were purchased from ChemDiv,Inc. (San Diego, Calif. ... μL) were plated in duplicatewells of a 96-well plate in the presence of each compound from theChemDiv kinase-biasedinhibitor library (ChemDiv, Inc., San Diego, Calif. ... observed withA-419259 were obtained in powder form from the provider of the original library(ChemDiv) and assayed a third time in triplicate at 1, 3, 10, and 30 μM incomparison with 5 μM A-419259.

SMALL MOLECULE INHIBITORS OF PDZ INTERACTIONS

BELMARES,Michael P. [US]; LU, Peter S.[US];MENDOZA, KennethA. [US]

Score: 16.234026 | Text size: 107715 | Find: similardocuments

withAccelrys software (Accelrys, San Diego, CA) to model and dock a 650,000molecule library (ChemDiv, San Diego, CA; Blanca Pharmaceuticals,Mountain View, CA) with 4 different PDZ domain mimics. ... multipleconformations for each molecule; and, 4) From approximately 650,000 testcompounds (ChemDiv, San Diego, CA; Blanca Pharmaceutical, Mountain View,CA.

External link

Estrogen receptor modulators and uses thereof

William J. Welsh[US];Nina Ching Y.Wang [US];Ni Ai [US]; William J. Welsh[US];Nina Ching Y.Wang [US];Ni Ai [US]

Score: 17.30191 | Text size: 49559 | Find: similardocuments

OSTEOCALCIN AS A TREATMENT FOR MALE REPRODUCTIVE DISORDERS

KARSENTY, Gerard[US];DUCY, Patricia,F. [US];KARSENTY, Gerard[US];DUCY, Patricia,F. [US]

Score: 9.838301 | Text size: 294633 | Find: similardocuments

YEAST CELLS EXPRESSING AMYLOID BETA AND USES THEREFOR

MATLACK, KentE.S. [US];LINDQUIST, SusanL. [US];MATLACK, KentE.S. [US];LINDQUIST, SusanL. [US]

Score: 14.039395 | Text size: 79644 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

SCREEN FOR INHIBITORS OF HIV REPLICATION

James W. Bruce[US];Paul G. Ahlquist[US];John A.T. Young[US];James W. Bruce[US];Paul G. Ahlquist[US];John A.T. Young[US]

Publicationdate: 2011-07-07 | Patent publication No.: US-20110165266-A1|Assignees: James W. Bruce [US]; Paul G. Ahlquist [US]; John A.T. Young [US] | IPC: A61K33/20;C12Q1/70; A61K31/085; A61P31/18 | Oldestpriority date: 2008-05-02 | Publication date: 2011-07-07

Score: 13.327991 | Text size: 104209 | Find: similardocuments

Othersuitable groups of compounds would include the Chembridge collection (16,000compounds), ChemDivcollection (20,000 compounds), and the NCI opencollection (140,000 compounds).

A CELL-BASED SCREENING ASSAY TO IDENTIFY MOLECULES THAT STIMULATEIFN-ALPHA/BETA TARGET GENES

VIDALAIN,Pierre-Olivier [FR]; TANGY,Frédéric [FR]; MUNIER-LEHMANN,Hélène [FR]; LUPAN, Alexandru[FR];LUCAS-HOURANI,Marianne [FR];JACOB, Yves [FR]; VIDALAIN,Pierre-Olivier [FR]; TANGY,Frédéric [FR]; MUNIER-LEHMANN,Hélène [FR]; LUPAN, Alexandru[FR];LUCAS-HOURANI,Marianne [FR]; JACOB, Yves [FR]

Publicationdate: 2011-07-07 | Patent publication No.: WO-2011080686-A1|Assignees: INSTITUT PASTEUR [FR]; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR] | IPC: G01N33/50;C12Q1/68 | Oldestpriority date: 2009-12-28 | Publication date: 2011-07-07

Score: 15.410318 | Text size: 37061 | Find: similardocuments

Threechemical compound libraries were used in this assay: Prestwick Chemical (1120molecules), ChemDivkinase inhibitors (9360 molecules) and NECANnucleoside analogs library (4880 molecules).

Amide, aryl sulfonamide, aryl urea, and α,β-diketone derived carboxylesteraseinhibitors, and their methods of use

Philip MichaelPotter [US];Janice LouiseHyatt [US];Christopher LeeMorton [US];Paul P. Beroza[US];Komath V.Damoradan [US]; Philip Michael Potter[US];Janice LouiseHyatt [US];Christopher LeeMorton [US];Paul P. Beroza[US];Komath V.Damoradan [US]

Score: 20.217176 | Text size: 68797 | Find: similardocuments

Louis,Mo.), ChemDiv (San Diego, Calif. ... Compounds Identified inTable 3 Com- pound Alternate Code Source Catalog # Source Catalog # 42 ChemDiv 1125-0434Asinex BAS 3819227 43 ChemDiv 000A-0340 Asinex BAS 1057195 44Asinex BAS 0126340 45 ChemDiv 0896-7238 Asinex BAS 012633546 ChemDiv 4049-0210ChemDiv 3365-0568 47 AsinexBAS 0459805 48 ChemDiv 0262-0298 Asinex BAS 0116665 49 SigmaAldrich S739391 50 Synthesis described herein 51 ChemDiv 0896-723952 ChemDiv 4063-0024 Asinex BAS 1358536 53 Sigma AldrichS607258 54 Sigma Aldrich S713805 55 Sigma Aldrich

CELL-BASED SCREENING ASSAY TO IDENTIFY MOLECULES THAT STIMULATEIFN-ALPHA/BETA TARGET GENES

Pierre-OlivierVidalain [FR]; Frederic Tangy[FR];HeleneMunier-Lehmann [FR]; Alexandru Lupan[FR];MarianneLucas-Hourani [FR]; Yves Jacob [FR]; Pierre-OlivierVidalain [FR]; Frederic Tangy[FR];HeleneMunier-Lehmann [FR]; Alexandru Lupan[FR];MarianneLucas-Hourani [FR]; Yves Jacob [FR]

Score: 15.3354435 | Text size: 35212 | Find: similardocuments

chemicalcompound libraries were used in this assay: Prestwick Chemical (1120molecules), ChemDiv kinase inhibitors (9360 molecules) andNECAN nucleoside analogs library (4880 molecules).

PARAMYXOVIRUS FAMILY INHIBITORS AND METHODS OF USE THEREOF

Richard K.Plemper [US]; James P. Snyder[US];Aiming Sun [US]; Richard K.Plemper [US]; James P. Snyder[US];Aiming Sun [US]

Publicationdate: 2011-06-30 | Patent publication No.: US-20110160188-A1|Assignees: Richard K. Plemper [US]; James P. Snyder [US]; Aiming Sun [US] | IPC: A61K31/55; C12Q1/70;C40B30/06; C07D401/12; C12N15/63; A61K31/4155; A61K31/454; A61P31/12 | Oldest priority date: 2007-02-09 | Publication date: 2011-06-30

Score: 12.892465 | Text size: 117471 | Find: similardocuments

The compoundlibrary used is a diversity set from ChemDiv (San Diego,Calif.). Example 3 Chemical synthesis of compound 16677.

COMPOUNDS FOR MODULATING TLR2

Robert W.Finberg [US]; Evelyn A.Kurt-Jones [US]; Shenghua Zhou[US];Robert W.Finberg [US]; Evelyn A.Kurt-Jones [US]; Shenghua Zhou[US]

Publicationdate: 2011-06-23 | Patent publication No.: US-20110152251-A1|Assignees: UNIVERSITY OF MASSACHUSETTS [US] | IPC:A61K31/5513;A61K31/496; A61K31/506; A61K31/437; A61K31/4725; A61K31/4433; A61K31/429;A61K31/423; C07D243/10; C07D403/10; C07D413/12; C07D471/04; C07D401/12;C07D513/04; C07D261/20; A61P31/12 | Oldestpriority date: 2009-11-18 | Publication date: 2011-06-23

Score: 14.999643 | Text size: 158710 | Find: similardocuments

Other commercialsources include ChemDiv, ChemBridge, Aurora, Tim Tec, andScientific exchange product list. ... Compound libraries screened includedthose from ChemDiv, Maybridge, ChemBridge, Biomol-TimTec, and someFungal Extracts.

Compositions and Methods for the Diagnosis and Treatment of AmyotrophicLateral Sclerosis

Aaron D. Gitler[US];Nancy Bonini[US];Aaron D. Gitler[US];Nancy Bonini[US]

Publicationdate: 2011-06-16 | Patent publication No.: US-20110142789-A1|Assignees: The Trustees of the University of Pennsylvania [US] | IPC: A61K31/79;C12Q1/68; C12Q1/02; A61P25/00; C08F8/32 | Oldest priority date: 2009-12-10 | Publication date: 2011-06-16

Score: 13.10661 | Text size: 109289 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS

Sanjay A. Desai[US];Ajay D. Pillai[IN];Sanjay A. Desai[US];Ajay D. Pillai[IN]

Publicationdate: 2011-06-16 | Patent publication No.: US-20110144086-A1|Assignees: The United States of America, as represented by the Secretary, Dept ofHealth and Human Service [US] | IPC: A61K31/554; A61K31/433; A61K31/423; A61K31/437; A61K31/4439; A61P33/06 |Oldestpriority date: 2008-07-23 | Publication date: 2011-06-16

Score: 14.165414 | Text size: 59520 | Find: similardocuments

methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, Calif. or Peakdale MolecularLimited, High Peak, England.

COMPOSITIONS AND METHODS FOR INHIBITING HUMAN HOST CELL FACTORS REQUIREDFOR INFLUENZA VIRUS REPLICATION

SHAW, Megan [US]; STERTZ, Silke[US];GARCIA-SASTRE,Adolfo [US];PALESE, Peter[US];YOUNG, John [US]; KONIG, Renate[US];CHANDA, Sumit[US];SHAW, Megan [US]; STERTZ, Silke[US];GARCIA-SASTRE,Adolfo [US];PALESE, Peter[US];YOUNG, John [US]; KONIG, Renate[US];CHANDA, Sumit[US]

Publicationdate: 2011-06-16 | Patent publication No.: WO-2011071535-A2|Assignees: MOUNT SINAI SCHOOL OF MEDICINE [US]; SALK INSTITUTE FOR BIOLOGICAL STUDIES[null]; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE [US] | IPC: C07H21/04 | Oldest priority date:2009-12-11 | Publication date: 2011-06-16

Score: 9.370946 | Text size: 338139 | Find: similardocuments

previously(Hoffmann et al., 2008) and diphyllin was identified from a library suppliedby ChemDiv (San Diego, CA).

COMPOUNDS FOR MODULATING TLR2

FINBERG, RobertW. [US];KURT-JONES,Evelyn A. [US]; ZHOU, Shenghua[US];FINBERG, RobertW. [US];KURT-JONES,Evelyn A. [US]; ZHOU, Shenghua[US]

Publicationdate: 2011-05-26 | Patent publication No.: WO-2011062955-A2|Assignees: UNIVERSITY OF MASSACHUSETTS [US] | IPC:A61K31/4245;A61K31/42; A61K31/505; A61K31/551; A61P29/00; A61P31/12 | Oldest priority date: 2009-11-18 | Publication date: 2011-05-26

Score: 15.290299 | Text size: 153556 | Find: similardocuments

COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGENPROTEINS

TYLER, Brett[US];KALE, Shiv [US]; ANTIGNANI,Vincenzo [US]; GU, Bioa [null]; TYLER, Brett[US];KALE, Shiv [US]; ANTIGNANI,Vincenzo [US]; GU, Bioa [null]

Publicationdate: 2011-05-19 | Patent publication No.: WO-2011060144-A2|Assignees: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. [US] | IPC: C07K5/08;C07K5/10; A61K38/06; A61K38/07; A01N63/02; C12N15/09 | Oldest priority date: 2009-11-11 | Publication date:2011-05-19

Score: 11.569273 | Text size: 190986 | Find: similardocuments

severalsources including established chemical vendors like Asinex, Analyticon, Biomol,Bionet, ChemDiv, Enami ne, Maybridge, Spectrum, TimTec as well as arange of diversity oriented synthesis

TRICYCLIC PYRAZOL AMINE DERIVATIVES

GAILLARD,Pascale [FR]; JEANCLAUDE-ETTER,Isabelle [CH]; POMEL, Vincent[FR];SEBILLE, Eric[FR];JEYAPRAKASHNARAYANAN,Seenisamy [IN];MUZERELLE,Mathilde [FR]; GAILLARD,Pascale [FR]; JEANCLAUDE-ETTER,Isabelle [CH]; POMEL, Vincent[FR];SEBILLE, Eric[FR];JEYAPRAKASHNARAYANAN,Seenisamy [IN]; MUZERELLE,Mathilde [FR]

Score: 8.557886 | Text size: 529678 | Find: similardocuments

compound B1, referenced under the Registry Number 931355-99-6, is commercially availablefrom ChemDivCompany. This compound was not used for anypharmaceutical or medical indication.

Methods for identifying small molecules that modulate prematuretranslation termination and nonsense mediated mRNA decay

Ellen M. Welch[US];Neil GregoryAlmstead [US]; Robert F. Rando[US];Mathew C.Pellegrini [US]; Ellen M. Welch[US];Neil GregoryAlmstead [US]; Robert F. Rando[US];Mathew C.Pellegrini [US]

Score: 7.2924438 | Text size: 522280 | Find: similardocuments

BIOMARKERS FOR PREDICTING THE SENSITIVITY AND RESPONSE OF PROTEIN KINASECK2-MEDIATED DISEASES TO CK2 INHIBITORS

DRYGIN, Denis[US];O'BRIEN, Sean [US]; ANDERES, Kenna[US];VONHOFF, Daniel,D. [US];LIM, John, K.,C. [US];PADGETT, Claire,S. [US];BLIESATH,Joshua, R. [US]; HO, Caroline, B.[US];RICE, William G.[US];SIDDIQUI-JAIN,Adam [US];DRYGIN, Denis[US];O'BRIEN, Sean [US];ANDERES, Kenna[US];VONHOFF, Daniel,D. [US];LIM, John, K.,C. [US];PADGETT, Claire,S. [US];BLIESATH,Joshua, R. [US]; HO, Caroline, B.[US];RICE, William G.[US];SIDDIQUI-JAIN,Adam [US]

Score: 9.838301 | Text size: 255247 | Find: similardocuments

Mo.), Maybridge(Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (San Diego, CA), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands),Timtec (Newark, DE), or alternatively can be

ANTI-ANGIOGENIC COMPOUNDS

Danzhi Huang[CH];Peter Kolb [AT]; Karine Lafleur[CH];Cristina Nevado[CH];Amedeo Caflisch[CH];Danzhi Huang[CH];Peter Kolb [AT]; Karine Lafleur[CH];Cristina Nevado[CH];Amedeo Caflisch[CH]

Score: 12.685205 | Text size: 119829 | Find: similardocuments

SMALL MOLECULE INHIBITORS OF THE ALPHA4-PAXILLIN INTERACTION

GINSBERG, Mark[US];KUMMER,Christiane [US]; GINSBERG, Mark[US];KUMMER,Christiane [US]

Publicationdate: 2011-03-24 | Patent publication No.: WO-2011034896-A2|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/4375;A61P11/06; A61P19/02; A61P29/00; A61P37/00 | Oldest priority date: 2009-09-18 | Publication date: 2011-03-24

Score: 18.761955 | Text size: 92270 | Find: similardocuments

Thefollowing libraries were screened: Mixed Commercials 1, 2 & 4, ChemDiv 1& 2, Specplus, Maybridge 2 & 3, Peakdale2, Starr Foundation Extracts 1& 2, Philippines Plant ... compounds was screened at a concentration of 16 μg/ml usingthe Mixed Commercials 1 , 2 & 4, ChemDiv 1 & 2, Specplus,Maybridge 2 & 3, Peakdale2, Starr Foundation Extracts 1 & 2,Philippines Plant ... inhibitor - In dose response ELTSA binding assays theinhibitory effect of compound 6-B345TTQ (ChemDiv, San Diego, CA) wasverified for the interaction of leupaxin with α4- integrin. Interestingly, anisomer (6-B234TTQ (ChemDiv, San Diego, CA)) that differed in theposition of one methoxy group was completely inactive towards

Integrin-binding small molecules

Neamati, Nouri[US];Dayam, Raveendra[US]

Publicationdate: 2011-03-23 | Patent publication No.: EP-2298308-A2|Assignees: University Of Southern California [US] | IPC:A61K31/52; A61K31/517; A61K31/195; A61K31/41; A61K31/4155; A61K31/4178;A61K31/425; A61K31/426; A61K31/427; A61K31/428; A61K31/4375; A61K31/4985;A61K31/519; A61K31/53; A61K31/635; A61K45/06; A61P35/00; A61P19/02; A61P19/10;A61P9/10 | Oldest prioritydate: 2005-11-14 | Publication date: 2011-03-23

Score: 14.719831 | Text size: 195056 | Find: similardocuments

External link

COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA

JolantaGrembecka [US]; Tomasz Cierpicki[US];Jay Hess [US]; JolantaGrembecka [US]; Tomasz Cierpicki[US];Jay Hess [US]

Publicationdate: 2011-03-17 | Patent publication No.: US-20110065690-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]; UNIVERSITY OF VIRGINIAPATENT FOUNDATION [US] | IPC: A61K31/519; C07D495/04; C07D491/048; A61K31/5377; A61K31/551; C07D401/04;C07D405/10; C07D243/38; A61P35/04; C12N5/02 | Oldest priority date: 2009-09-04 | Publication date: 2011-03-17

Score: 20.573181 | Text size: 69975 | Find: similardocuments

assay withFLSNMLL (μM)Vendor/Cat # IC50 in HTRF assay (μM) Compound 32[[image:EMI-C00065]] 13ChemDiv Inc. Cat # 4780-0051 7 Compound 33[[image:EMI-C00066]] 29 ChemDiv Inc. Cat # 5742-0717 28Compound 34 [[image:EMI-C00067]] 12 ChemDiv Inc. Cat #3393-0109 ND Compound 35 [[image:EMI-C00068]] 35 ChemDiv Inc. Cat# 3393-0126 ND Compound 36 [[image:EMI-C00069]] 63 ChemDiv Inc. Cat# 3170-5216 ND Compound 37 [[image:EMI-C00070]] 100 ChemDiv Inc. Cat# 3404-5359 ND Compound 38 [[image:EMI-C00071]] 115 ChemBridge Cat # 6369841 NDCompound 39 [[image:EMI-C00072]] 230 ChemDiv Inc. Cat #3170-5232 ND Compound 40 [[image:EMI-C00073]] NA ChemDiv Inc. Cat# 5531-8211 ND Compound 41 [[image:EMI-C00074]] NA ChemDiv Inc. Cat# 3770-0060 ND Compound 84 [[image:EMI-C00075]] 100 Interbioscreen STOCK2S-

NOVEL AGENTS OF CALCIUM ION CHANNEL MODULATORS

Jay Jie-Qiang Wu[US];Jay Jie-Qiang Wu[US]

Publicationdate: 2011-03-17 | Patent publication No.: US-20110065703-A1|Assignees: Jay Jie-Qiang Wu [US] | IPC: A61K31/5377; C07D491/08; C07D498/08; A61K31/444; A61K31/407; A61K31/496;A61K31/424; A61K31/4355; A61K31/4439; A61P25/08; A61P25/16; A61P25/00;A61P25/18; A61P9/12; A61P9/10; A61P25/22; A61P25/28; A61P35/00; A61P3/10;C07D487/04; C07D401/14; C07D403/06; C07D513/04; C07D215/56; C07D401/04;C07D413/14; A61K31/475; A61K31/519; A61K31/517; A61K31/4745; A61K31/404;A61K31/4985; A61K31/10 | Oldestpriority date: 2007-03-12 | Publication date: 2011-03-17

Score: 10.354719 | Text size: 255920 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

METHODS OF IDENTIFYING COMPOUNDS THAT INHIBIT THE ACTIVATION OF ABIOMOLECULE AND METHODS OF TREATMENT USING THE COMPOUNDS

ThérèseMalliavin [FR]; Elodie Laine[FR];Arnaud Blondel[FR];Daniel Ladant[FR];Johanna Karst[FR];Sylvain Rault[FR];AurélienLesnard [FR];ThérèseMalliavin [FR]; Elodie Laine[FR];Arnaud Blondel[FR];Daniel Ladant[FR];Johanna Karst[FR];Sylvain Rault[FR];AurélienLesnard [FR]

Publicationdate: 2011-03-17 | Patent publication No.: US-20110065782-A1|Assignees: Thérèse Malliavin [FR]; Elodie Laine [FR]; Arnaud Blondel[FR]; Daniel Ladant [FR]; Johanna Karst [FR]; Sylvain Rault [FR];Aurélien Lesnard [FR] | IPC: A61K31/38; C40B30/00; C40B30/02; C07D333/36 | Oldest priority date: 2009-09-15 | Publication date: 2011-03-17

Score: 13.793969 | Text size: 116780 | Find: similardocuments

Nationale(France) and corporate entities like Chembridge Corp., San Diego, Calif.and ChemDiv Inc., San Diego, Calif.

DIHYDROPYRIDINE DERIVATIVES

VAN STRATEN,Nicole, Corine Renee [NL]; GERRITSMA,Gerritdina Geziena [NL]; VAN DER VEEN,Lars Anders [NL]

Score: 14.293713 | Text size: 71760 | Find: similardocuments

sources likeChembridge Corp, MicroChemistry Ltd, Ambinter, Asinex, Scientific Exchange Inc,and ChemDiv Inc. Suitable methods for the preparation of thecompounds of the invention are outlined below.

External link

COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA

HESS, Jay [US]; GREMBECKA,Jolanta [US]; CIERPICKI,Tomasz [US];HESS, Jay [US]; GREMBECKA,Jolanta [US]; CIERPICKI,Tomasz [US]

Publicationdate: 2011-03-10 | Patent publication No.: WO-2011029054-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]; UNIVERSITY OF VIRGINIAPATENT FOUNDATION [US] | IPC: A01N43/90; A61K31/519 | Oldest prioritydate: 2009-09-04 | Publication date: 2011-03-10

Score: 14.039395 | Text size: 69593 | Find: similardocuments

availablefrom Interbio Screen Ltd., Compounds 11 and 32-41 are commercially availablefrom Chemdiv Inc.Compounds 12-27 and 31 are commercially availablefrom Enamine.

YEAST CELLS EXPRESSING TAR DNA-BINDING PROTEIN 43 AND USES THEREFOR

Susan L.Lindquist [US]; Aaron D. Gitler[US];Susan L.Lindquist [US]; Aaron D. Gitler[US]

Publicationdate: 2011-03-03 | Patent publication No.: US-20110053857-A1|Assignees: Whitehead Institute for Biomedical Research [US] | IPC: A61K38/02;C12N1/19; C12N1/06; C12Q1/68; C12N5/071; A61P25/28 | Oldest priority date: 2008-02-15 | Publication date: 2011-03-03

Score: 14.039395 | Text size: 78467 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

SMALL MOLECULE E2F INHIBITOR

Douglas W. Cress[US];Yihong Ma [US]; Douglas W. Cress[US];Yihong Ma [US]

Publicationdate: 2011-03-03 | Patent publication No.: US-20110053977-A1|Assignees: UNIVERSITY OF SOUTH FLORIDA [US]; H. Lee Moffitt Cancer Center and ResearchInstitute, Inc. [US] | IPC: A61K31/4709; C12N5/071; A61P35/00; A61P35/02 | Oldest priority date: 2008-03-18 | Publication date: 2011-03-03

Score: 17.021982 | Text size: 63712 | Find: similardocuments

Schrödinger,Portland, Oreg.) was used to screen a 20,000 compound 3D chemical database(from ChemDiv, Inc) (see He Y, Armanious M K, Thomas M J, Cress WD. Identification of E2F-3B, an alternative form of ... LigPrep 1.5 was used toconvert a 2D structural database of these 20,000 compounds (obtained from ChemDiv asan MDL sdf file) into a database of 3D structures for virtual screening.

HETEROCYCLIC INHIBITORS OF AN Hh-SIGNAL CASCADE, MEDICINAL COMPOSITIONSBASED THEREON AND METHODS FOR TREATING DISEASES CAUSED BY THE ABERRANT ACTIVITYOF AN Hh-SIGNAL SYSTEM

AndreyAlexandrovich Ivaschenko [RU]; Yan VadimovichLavrovsky [US]; SergeyViktorovich Malyarchuk [US]; Ilya MatusovichOkun [US];NikolayFilippovich Savchuk [US]; SergeyYevgenievich Tkachenko [US]; AlexanderViktorovich Khvat [US]; AlexanderVasilievich Ivaschenko [US]; AndreyAlexandrovich Ivaschenko [RU]; Yan VadimovichLavrovsky [US]; SergeyViktorovich Malyarchuk [US]; Ilya MatusovichOkun [US];NikolayFilippovich Savchuk [US]; SergeyYevgenievich Tkachenko [US]; AlexanderViktorovich Khvat [US]; AlexanderVasilievich Ivaschenko [US]

Publicationdate: 2011-03-03 | Patent publication No.: US-20110053915-A1|Assignees: ALLA CHEM, LLC [US] | IPC: A61K31/55; A61K31/5025; C07D487/04; A61K31/5377; A61K31/542; C07D513/04;A61P35/00; A61K31/437; C07D471/04; A61K31/519; C07D495/04; A61K31/454;A61K31/496; A61K31/438; A61K31/4545; C07D401/04; C07D215/58; A61K31/47;A61K31/4365 | Oldestpriority date: 2007-12-14 | Publication date: 2011-03-03

Score: 12.290053 | Text size: 208303 | Find: similardocuments

fromcommercial sources, such as Acros (Belgium), Sigma-Aldrich (USA), Lancaster(England) and ChemDiv(USA). Melting points were determined withinstrument Buchi (Switzerland), model B-520.

METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS

Jay Jie-Qiang WU[US];Jay Jie-Qiang WU[US]

Publicationdate: 2011-03-03 | Patent publication No.: US-20110053960-A1|Assignees: VM DISCOVERY INC. [US] | IPC: A61K31/519; A61P29/00; A61P25/06; A61P25/08; A61P35/00; A61P3/10; A61P9/10;A61P31/12; A61P19/02; A61P25/30; A61P25/22; A61P25/24; A61P25/28; C12N5/00 | Oldest priority date: 2008-02-29 | Publication date: 2011-03-03

Score: 12.685205 | Text size: 100463 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, N.C.), ChemBridge (SanDiego, Calif.), ChemDiv(San Diego, Calif.), SPECS (Delft, TheNetherlands), Timtec (Newark, Del.

BENZENESULFONANILIDE COMPOUND INHIBITORS OF UREA TRANSPORTERS

Alan S. Verkman[US];Marc HarrisLevin [US];Alan S. Verkman[US];Marc HarrisLevin [US]

Publicationdate: 2011-03-03 | Patent publication No.: US-20110053995-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/423;A61K31/18; A61K31/357; C12N5/071; C12N5/079; C12N5/078; A61P13/00; A61P9/00;A61P1/16; A61P13/12; A61P9/12; A61P9/04 | Oldest priority date: 2006-11-16 | Publication date: 2011-03-03

Score: 15.290299 | Text size: 145022 | Find: similardocuments

drug-likecompounds (>90% with molecular size of 250-500 Da) obtained from acommercial source (CHEMDIV Inc., San Diego, Calif. ... Studies of UT-BInhibitors The activity of approximately 700 commercially available analogs (ChemDivInc. and Asinex; Moscow, Russia) of active compounds from the fourdistinct chemical structural classes

DETECTING METHODS OF DNA AMPLIFICATION USING NEW INTERCALATING AGENT

LEE, Jun Hee[KR];PARK, Hwang Seo[KR];HAN, Eun Su [KR]; LEE, Jae Don[KR];PARK, Han Oh[KR];LEE, Jun Hee[KR];PARK, Hwang Seo[KR];HAN, Eun Su [KR]; LEE, Jae Don[KR];PARK, Han Oh[KR]

Score: 15.261294 | Text size: 36882 | Find: similardocuments

fluorescentcompounds [86] Compound libraries were purchased from InterBioScreen, ASINEX,Specs,ChemDiv, etc.

Method for determining inhibitors of neurotrypsin

PeterSonderegger [CH]; Stefan Hettwer[CH];Marc F. Bolliger[CH];Birgit Dreier[CH];Beat Kunz [CH]; DanielLüscher [CH]; Raymond Reif[CH];Susanne Sales[CH];PeterSonderegger [CH]; Stefan Hettwer[CH];Marc F. Bolliger[CH];Birgit Dreier[CH];Beat Kunz [CH]; DanielLüscher [CH];Raymond Reif[CH];Susanne Sales[CH]

Score: 11.918776 | Text size: 159471 | Find: similardocuments

Compound No.7 (identification number 1672-3440 from ChemDiv, San Diego, Calif.

ANTIBIOTIC COMPOUNDS

Kim Lewis [US]; Gabriele Casadei[US];Kim Lewis [US]; Gabriele Casadei[US]

Publicationdate: 2011-02-24 | Patent publication No.: US-20110046142-A1|Assignees: Northeastern University [US] | IPC: A61K31/53; A61K31/34; A61K31/381; A61K31/496; A61K31/436; A61K31/498;A61K31/47; A61K31/407; A61P31/00; A61P31/04; A61P31/10; A61P33/02; A61P17/02;A61P11/00; A61P9/00 | Oldestpriority date: 2007-06-13 | Publication date: 2011-02-24

Score: 15.75832 | Text size: 198049 | Find: similardocuments

the NationalInstitutes of Health Molecular Library Screening Center, The ChemBridge Library,the ChemDivLibrary, and the MayBridge Library. ... Microformat50,000 0686-0842 ChemDiv1 (Combilab and International) 28,864 0587-0668 ChemDiv 28,560 1369-1393 ChemDiv 3 16,544 1473-1519ChemDiv-Anti-Mitotic Collection 1,254 1157-1160 Enamine 1 6,004 1394-1411 I.F.

INHIBITORS OF BOTULINUM NEUROTOXINS

BOWLIN, Terry,L. [US];PEET, Norton, P.[US];BUTLER,Michelle, M. [US]; CARDINALE,Steven, C. [US]; LI, Bing [US]; PAI, Ramdas [US]; BOWLIN, Terry,L. [US];PEET, Norton, P.[US];BUTLER,Michelle, M. [US]; CARDINALE,Steven, C. [US]; LI, Bing [US]; PAI, Ramdas [US]

Score: 17.9036 | Text size: 88094 | Find: similardocuments

such asChemBridge Corporation (San Diego, CA, USA), Life Chemicals hie. (Burlington,ON, Canada), ChemDiv Inc. (San Diego, CA, USA), MicrosourceCorporation (Gaylordsville, CT, USA), Timtec LLC (Newark, DE, ... AssayChemical compound libraries were purchased from Chembridge Corporation (SanDiego, CA), ChemDiv Incorporated (San Diego, CA), and fromMicrosource Corporation (Gaylordsville, CT). ... Quinolones were the onlystructural class of inhibitors identified in both the Chembridge and ChemDiv screeninglibraries used in the screens.

TRP INHIBITORS AND USES THEREOF

CRAWFORD, John,Stuart [US];OSTERTAG, Eric[US];CRAWFORD, John,Stuart [US];OSTERTAG, Eric[US]

Publicationdate: 2011-02-24 | Patent publication No.: WO-2011022638-A1|Assignees: TRANSPOSAGEN BIOPHARMACEUTICALS, INC. [US] | IPC: C07K14/705;A61K31/00; C12N15/113; A61P25/04 | Oldestpriority date: 2009-08-20 | Publication date: 2011-02-24

Score: 12.290053 | Text size: 132063 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigrna-Aldrich (St.Louis, Mo.

Pro-Neurogenic Compounds

STEVEN L.MCKNIGHT [US]; ANDREW A. PIEPER[US];JOSEPH M. READY[US];JEF K. DEBRABANDER [US]; STEVEN L.MCKNIGHT [US]; ANDREW A. PIEPER[US];JOSEPH M. READY[US];JEF K. DEBRABANDER [US]

Publicationdate: 2011-01-20 | Patent publication No.: US-20110015217-A1|Assignees: STEVEN L. MCKNIGHT [US]; ANDREW A. PIEPER [US]; JOSEPH M. READY [US]; JEFK. DE BRABANDER [US] | IPC: A61K31/506; A61P25/28; A61P25/16; A61P25/30; A61K31/403; A61K31/4439;A61K31/422; A61K31/4045; A61K31/437; A61K31/4155 | Oldest priority date: 2009-01-09 | Publication date: 2011-01-20

Score: 19.36226 | Text size: 300817 | Find: similardocuments

from ChemDiv,Inc. Example 591-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol[[image:EMI-C00109]] Purchased from ChemDiv, Inc. Example 60 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00110]] Purchased from ChemDiv, Inc. Example 611-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00111]] Purchased fromChemDiv, Inc. Example 62 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00112]] Purchased from ChemDiv, Inc. Example 631-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00113]] Purchased from ChemDiv, Inc. Example

INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS

Alan S. Verkman[US];Ricardo De LaFuente Gonzalez [ES]; Alan S. Verkman[US];Ricardo De LaFuente Gonzalez [ES]

Publicationdate: 2011-01-20 | Patent publication No.: US-20110015239-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/426;C12N5/07; C12Q1/02; A61K31/381; A61P1/12; A61P11/06; A61P11/00 | Oldest priority date: 2007-12-14 |Publicationdate: 2011-01-20

Score: 14.450268 | Text size: 203567 | Find: similardocuments

Compoundsfor primary screening were purchased from ChemDiv (San Diego,Calif. ... Compounds for the secondary screening were purchased from ChemDiv andAsinex.

NEW INHIBITORS OF PROLINE RACEMASE ENZYMES

MINOPRIO, Paola[FR];BERNEMAN, Armand[FR];BLONDEL, Arnaud[FR];MINOPRIO, Paola[FR];BERNEMAN, Armand[FR];BLONDEL, Arnaud[FR]

Score: 19.46057 | Text size: 83229 | Find: similardocuments

the virtualscreening of several thousand molecules out of two accessible chemicallibraries: ChemDiv, Inc(San Diego, California, USA) andChimiotheque Nationale (CNRS, France). ... for the virtual screening of 31000compounds of the Chimioheque Nationale and 63000 compounds of ChemDiv chemicallibraries (www.chemdiv.com; www.chimiotheque-nationale.enscm. ... perform thevirtual screening of about 700.000 molecules from two accessible chemicallibraries: ChemDiv, Inc (San Diego, California, USA) andChimiotheque Nationale (CN, CNRS, France). ... virtual screening of 31000compounds of the Chimiotheque Nationale (CN) and 630000 compounds of ChemDiv chemicallibraries.

Inhibitors of the proline racemase of trypanosoma cruzi

Minoprio, paola[FR];Berneman, Armand[FR];Blondel, Arnaud[FR]

Score: 19.508682 | Text size: 73051 | Find: similardocuments

the virtualscreening of several thousand molecules out of two accessible chemicallibraries: ChemDiv, Inc(San Diego, California, USA) andChimiothèque Nationale (CNRS, France). ... for the virtual screening of31000 compounds of the Chimiohèque Nationale and 63000 compoundsof ChemDiv chemical libraries (www.chemdiv.com;www.chimiotheque-nationale.enscm. ... perform the virtual screening of about700.000 molecules from two accessible chemical libraries: ChemDiv, Inc (SanDiego, California, USA) and Chimiothèque Nationale (CN, CNRS, France).... virtual screening of 31000 compounds of the Chimiothèque Nationale(CN) and 630000 compounds of ChemDiv chemical libraries.

External link

Pro-Neurogenic Compounds

Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]; Steven L.McKnight [US]; Andrew A. Pieper[US];Joseph M. Ready[US];Jef K. DeBrabander [US]

Publicationdate: 2011-01-06 | Patent publication No.: US-20110003836-A1|Assignees: Steven L. McKnight [US]; Andrew A. Pieper [US]; Joseph M. Ready [US]; JefK. De Brabander [US] | IPC: A61K31/404; C07D209/88; C07D401/06; A61K31/4439; C07D471/04; A61K31/437;C07D403/12; A61K31/506; C07D209/08; A61K31/4045; A61P25/28; A61P25/18;A61P25/30; A61P25/00; A61P25/08; A61P25/14; A61P25/24 |Oldest priority date: 2009-01-09 | Publicationdate: 2011-01-06

Score: 18.614819 | Text size: 463556 | Find: similardocuments

from ChemDiv,Inc. Example 59 1-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol[[image:EMI-C00129]] Purchased from ChemDiv, Inc. Example 601-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:EMI-C00130]] Purchased from ChemDiv, Inc. Example 611-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan-2-ol[[image:EMI-C00131]] Purchased fromChemDiv, Inc. Example 621-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan-2-ol[[image:EMI-C00132]] Purchased from ChemDiv, Inc. Example 631-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:EMI-C00133]] Purchased from ChemDiv, Inc. Example

CRYSTAL OF XPA AND ERCC1 COMPLEX AND USES THEREOF

Orlando D.Schärer [US]; Tom Ellenberger[US];Oleg V. Tsodikov[US];Orlando D.Schärer [US]; Tom Ellenberger[US];Oleg V. Tsodikov[US]

Publicationdate: 2010-12-30 | Patent publication No.: US-20100331233-A1|Assignees: Orlando D. Schärer [US]; Tom Ellenberger [US]; Oleg V. Tsodikov [US] | IPC: A61K38/00;G01N33/566; C07K7/00; C07K14/435; C07K7/08; C07K7/06; A61P35/00 | Oldest priority date: 2007-10-05 | Publication date: 2010-12-30

Score: 11.918776 | Text size: 214474 | Find: similardocuments

MaybridgeHitFinder (14,379 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352 compounds);ChemDiv Combilaband International (28,864 compounds); Mixed Commercial Plate 1 (352 compounds);Mixed

INHIBITORS OF USP1 DEUBIQUITINATING ENZYME COMPLEX

Alan D'Andrea[US];Alan D'Andrea[US]

Score: 11.569273 | Text size: 156921 | Find: similardocuments

consists ofknown bioactive libraries, natural product libraries, and commercial librariessuch as ChemDiv, ChemBridge etc.

ANTIMICROBIAL COMPOUNDS

MOY, Terence [US]; CONERY, Annie[US];LEWIS, Kim [US]; AUSUBEL,Frederick, M. [US]; PUKKILA-WORLEY,Read [US];MOY, Terence[US];CONERY, Annie[US];LEWIS, Kim [US]; AUSUBEL,Frederick, M. [US]; PUKKILA-WORLEY,Read [US]

Publicationdate: 2010-12-29 | Patent publication No.: WO-2010151784-A2|Assignees: THE GENERAL HOSPITAL CORPORATION [US]; NORTHEASTERN UNIVERSITY [US] | IPC: A61K31/4427;A61K31/4725; A61K31/427; A61K31/501; A61P11/00; A61P29/00 | Oldest priority date:2009-06-26 | Publication date: 2010-12-29

Score: 17.9036 | Text size: 86484 | Find: similardocuments

BiologyProgram, Broad Institute, Cambridge, MA), ChemBridge kinases (San Diego,CA), ChemDiv (San Diego, CA), TimTec (Newark, DE), MayBridge(Cornwall, UK), and ChemBridge (San Diego, CA). ... Synthesis (DOS) 11,666 10.01% ChemBridge kinases 8,240 21 0.27% Commercial compounds: ChemDiv 11,61612 0.10% TimTec 8,512 7 0.08% MayBridge 5,448 3 0.06% ChemBridge 704 1 0.14%Total 53,946* ... Example 6: Antimicrobial Assay METHODS Compounds 6, 7, 15were purchased from TimTec and ChemDiv, dissolved in DMSO at aconcentration of 5 or 10 mg/ml, and further diluted in DMSO as indicated.

COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF INFLAMMATORYDISORDERS AND FIBROTIC DISEASE

RENNARD,Stephen, I. [US]; SATO, Tadashi[US];LIU, Xiang-der[US];HOLZ, Olaf [DE]; MAGNUSSEN, Helgo[DE];RENNARD,Stephen, I. [US]; SATO, Tadashi[US];LIU, Xiang-der[US];HOLZ, Olaf [DE]; MAGNUSSEN, Helgo[DE]

Publicationdate: 2010-12-29 | Patent publication No.: WO-2010151640-A2|Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA [US] | IPC: C12N15/63;C12N15/113; C12Q1/68; A61K48/00; A61P31/00 | Oldest priority date: 2009-06-24 | Publication date:2010-12-29

Score: 11.569273 | Text size: 167102 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

COMPOUNDS AND METHODS

Johan Wannberg[SE];Mathias Alterman[SE];Patric Stenberg[SE];Jacob Westman[SE];Johan Wannberg[SE];Mathias Alterman[SE];Patric Stenberg[SE];Jacob Westman[SE]

Publicationdate: 2010-12-23 | Patent publication No.: US-20100324086-A1|Assignees: Novasaid AB [SE] | IPC: A61K31/472; C07C237/52; A61K31/167; A61P35/00; A61P29/00; C07D215/42;A61K31/4706; C07D217/02; A61K31/44; C07D213/40; C07D235/30; A61K31/4184;C07D277/82; A61K31/428 | Oldestpriority date: 2008-02-19 | Publication date: 2010-12-23

Score: 12.484504 | Text size: 152390 | Find: similardocuments

iscommercially available from several sources such as ChemDiv,(http://www.chemdiv.com/) and ChemBridge (http://www.chembridge.com) etc.

INHIBITORS OF CONSTITUTIVELY ACTIVE JANUS KINASES AND USES THEREOF

CONSTANTINESCU,Stefan N. [BE]; DUSA, Alexandra[BE];CONSTANTINESCU,Stefan N. [BE]; DUSA, Alexandra[BE]

Score: 12.685205 | Text size: 153571 | Find: similardocuments

fromcommercial and academic sources, for example, from Sigma- Aldrich(www.sigmaaldrich.com), ChemDiv(www.chemdiv.com), Evotec(www.evotec.com ), or ICCB (iccb.med.harvard.

TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

Steven AlbertEverett [US]; Saraj Ulhaq [GB]; Steven AlbertEverett [US]; Saraj Ulhaq [GB]

Publicationdate: 2010-12-02 | Patent publication No.: US-20100305070-A1|Assignees: The University Court of the University of Dundee [GB] | IPC: A61K31/665;C07F9/24; C07D407/12; C07D311/08; C07D405/12; C07D417/12; C07D405/04;C07D405/14; C07D307/81; C07D471/12; C07D487/04; A61K31/352; A61K31/4184;A61K31/428; A61K31/513; A61K31/343; A61K31/4375; A61K31/5025; A61K31/519;A61K31/517; G01N33/567; C12Q1/26; G01N33/566; A61P35/00; A61P35/02; A61P17/06;A61P19/08; A61P9/10 | Oldestpriority date: 2009-05-01 |Publicationdate: 2010-12-02

Score: 15.970954 | Text size: 231278 | Find: similardocuments

PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS

Alan S. Verkman[US];Marc HarrisLevin [US];Alan S. Verkman[US];Marc HarrisLevin [US]

Publicationdate: 2010-12-02 | Patent publication No.: US-20100305105-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/55;A61K31/421; A61K31/5377; A61K31/4164; C12N5/07; A61P13/12; A61P9/00; A61P5/00;A61P1/16 | Oldestpriority date: 2006-11-16 | Publication date: 2010-12-02

Score: 15.290299 | Text size: 156146 | Find: similardocuments

Bis-aromatic amides and their uses as sweet flavor modifiers, tastants,and taste enhancers

CatherineTachdjian [US]; Andrew P. Patron[US];Farid Bakir [US]; Claudia Averbuj[US];Chad Priest [US]; Sara L.Adamski-Werner [US]; Qing Chen [US]; VincentDarmohusodo [US]; Marketa Lebl-Rinnova[US];Rachel D. A.Kimmich [US]; Xiao-Qing Tang[US];Rhondi Shigemura[US];CatherineTachdjian [US]; Andrew P. Patron[US];Farid Bakir [US]; Claudia Averbuj[US];Chad Priest [US]; Sara L.Adamski-Werner [US]; Qing Chen [US]; VincentDarmohusodo [US]; MarketaLebl-Rinnova [US]; Rachel D. A.Kimmich [US]; Xiao-Qing Tang[US];Rhondi Shigemura[US]

Score: 9.370946 | Text size: 325715 | Find: similardocuments

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia Pa., ChemDiv of San Diego, Calif., Chembridge of SanDiego, Calif.

SMALL MOLECULE INHIBITORS OF PDZ INTERACTIONS

MICHAEL P.BELMARES [US]; Peter S. Lu [US]; Kenneth A.Mendoza [US]; MICHAEL P.BELMARES [US]; Peter S. Lu [US]; Kenneth A.Mendoza [US]

Publicationdate: 2010-11-25 | Patent publication No.: US-20100298360-A1|Assignees: MICHAEL P. BELMARES [US]; Peter S. Lu [US]; Kenneth A. Mendoza [US] | IPC: A61K31/519;A61K31/405; A61K31/196; A61P9/00; A61P29/00 | Oldest priority date: 2005-12-30 |Publicationdate: 2010-11-25

Score: 16.068731 | Text size: 119816 | Find: similardocuments

Compounds and assays for controlling Wnt activity

Publicationdate: 2010-11-25 | Patent publication No.: US-20100298200-A1|Assignees: Dakai Liu [US]; Xiaofeng Li [US]; Richard Jin [US]; Yuaxin Liang [US]; WeiCheng [US]; Riddhi Bhattacharyya [US]; Guangrong Zhang [US] | IPC: A61K38/02;C07D265/38; C07C309/53; C07C235/56; C07D251/70; C07C229/66; A61K31/538;A61K31/196; A61K31/185; A61K31/277; A61K31/53; A61K31/245; A61K31/366;A61K31/12; A61K31/165; A61K31/167; A61K31/505; A61K31/122; A61K31/235;A61K31/05; A61K31/365; A61K31/343; A61P31/12; A61P25/00; A61P19/00; A61P35/00;A61P3/08; A61P3/06; G01N33/00; C12Q1/02; C12Q1/68; G01N33/53; G01N33/542;C40B30/04; C40B30/02; C12N5/10; C12Q1/66 | Oldest priority date: 2009-05-22 | Publication date: 2010-11-25

Score: 11.569273 | Text size: 181907 | Find: similardocuments

from the NCldatabase/chemical library as well as commercial database/chemical librariesfrom ChemDiv, Inc.(San Diego, Calif.), Chembridge Corporation (SanDiego, Calif.

IMIDAZO [ 1, 2 -A] PYRIDIN-2 -YL-PHENYL DERIVATIVES TO BE USED IN CANCERTREATMENT

KHVAT, Alexander[US];TKACHENKO,Sergey [US];OKUN, Ilya [US]; ROGOVOY, BorysV. [US];SAVCHUK, Nikolay[US];MAY, John [US]; O'CONNOR,Patrick [US]; RIPKA, William[US];VERNIER,Jean-Michel [US]; MATTHEWS, David[US];KHVAT, Alexander[US];TKACHENKO,Sergey [US];OKUN, Ilya [US]; ROGOVOY, BorysV. [US];SAVCHUK, Nikolay[US];MAY, John [US]; O'CONNOR,Patrick [US]; RIPKA, William[US];VERNIER,Jean-Michel [US]; MATTHEWS, David[US]

Publicationdate: 2010-11-11 | Patent publication No.: WO-2010129620-A1|Assignees: LIMITED LIABILITY COMPANY "INNOVATIVE PHARMA" [null] | IPC: C07D471/04;A61K31/437; A61P35/00 | Oldestpriority date: 2009-05-05 | Publication date: 2010-11-11

Score: 13.556976 | Text size: 87580 | Find: similardocuments

fromcommercial sources, such as Acros (Belgium), Sigma-Aldrich (USA), Lancaster(England) and ChemDiv(USA). Melting points were determined with instrumentBuchi (Switzerland) model B-520.

PLASMODIAL POLYNUCLEOTIDES, PROTEINS AND USES THEREOF

COWMAN, Alan[AU];CRABB, BrendanScott [AU];DE KONING-WARD,Tania Frances [AU]; GILSON, PaulRene [AU];COWMAN, Alan[AU];CRABB, BrendanScott [AU];DE KONING-WARD,Tania Frances [AU]; GILSON, PaulRene [AU]

Publicationdate: 2010-11-11 | Patent publication No.: WO-2010127398-A1|Assignees: THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH [AU]; THE BURNETINSTITUTE [AU] | IPC: C07K14/445; A61P33/06; G01N33/569; A61K39/015; C12Q1/00; G01N33/68 |Oldestpriority date: 2009-05-05 | Publication date: 2010-11-11

Score: 13.939713 | Text size: 262071 | Find: similardocuments

librariesinclude libraries such as the ChemBridge Library (ChemBridge Corp., San Diego,CA), the ChemDivlibrary (ChemDiv, Inc., San Diego, CA),Prestwick Library, (Prestwick Chemical's, lllkirch, France), MicroSourceLibrary

TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

EVERETT, Steven,Albert [US];ULHAQ, Saraj[GB];EVERETT, Steven,Albert [US];ULHAQ, Saraj[GB]

Publicationdate: 2010-11-04 | Patent publication No.: WO-2010125350-A1|Assignees: UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE [GB] | IPC: A61K31/343;A61K31/352; A61K31/4184; A61K31/428; A61K31/664; C07D307/80; C07D311/16;C07D405/12; C07D405/14; C07D407/12; C07D409/12; C07D417/12; A61P35/00; A61P9/10|Oldestpriority date: 2009-05-01 | Publication date: 2010-11-04

Score: 15.970954 | Text size: 238216 | Find: similardocuments

METHODS AND COMPOSITIONS FOR TREATING SKIN CONDITIONS

Kevin Pojasek[US];David Steinberg[US];Daphne Zohar[US];Kevin Pojasek[US];David Steinberg[US];Daphne Zohar[US]

Score: 10.354719 | Text size: 179028 | Find: similardocuments

receptorkinase inhibitors (Affymax), KDR kinase inhibitors (Wyeth), XL 820, VEGFR2inhibitors (ChemDiv), CHIR 265, KDR kinase inhibitors (Amgen), VEGFantagonists (Vegenics), PTC 299, VEGF receptor 2

COMPOUNDS AND METHODS FOR TREATINGMAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS

HEDSTROM,Lizbeth, K. [US]; CUNY, Gregory,D. [US];GOLLAPALLI,Deviprasad, R. [US]; KIRUBAKARAN,Sivapriya [IN]; STRIEPEN, Boris[US];GORLA, Suresh,Kumar [US];MAURYA, Sushi,K. [GB];JOHNSON, Corey,Robert [US];KAVITHA,Mandapati [US]; KHAN, JIHAN,[US];HEDSTROM,Lizbeth, K. [US]; CUNY, Gregory,D. [US];GOLLAPALLI,Deviprasad, R. [US]; KIRUBAKARAN,Sivapriya [IN]; STRIEPEN, Boris[US];GORLA, Suresh,Kumar [US];MAURYA, Sushi,K. [GB];JOHNSON, Corey,Robert [US];KAVITHA,Mandapati [US]; KHAN, JIHAN,[US]

Publicationdate: 2010-09-23 | Patent publication No.: WO-2010108187-A2|Assignees: BRANDEIS UNIVERSITY [US]; UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.[US] |IPC: C07D249/06; C07D401/12; C07D417/14; C07D401/14; A61K31/4192; A61P37/00;A61P19/02 | Oldestpriority date: 2009-03-20 | Publication date: 2010-09-23

Score: 10.633806 | Text size: 241925 | Find: similardocuments

Compounds D,E, F, G, and H were purchased from ChemDiv Inc. (San Diego,CA), Compounds A, B and C were synthesized as described previously.

COMPOSITIONS AND METHODS FOR POTENTIATING ANTIBIOTIC ACTIVITY

GuillaumeCottarel [US]; Timothy S.Gardner [US]; Xiaoguang Lei[CN];John Porco [US]; Scott E. Schaus[US];JameyWierzbowski [US]; Kollol Pal [US]; GuillaumeCottarel [US]; Timothy S.Gardner [US]; Xiaoguang Lei[CN];John Porco [US]; Scott E. Schaus[US];JameyWierzbowski [US]; Kollol Pal [US]

Publicationdate: 2010-09-16 | Patent publication No.: US-20100234348-A1|Assignees: TRUSTEES OF BOSTON UNIVERSITY [US] | IPC:A61K31/4035; C07D405/08; C07D487/04; C07D498/06; C07C69/00; C07D231/56;A61K31/5025; A61K31/553; A61K31/22; A61K31/416; C12Q1/18; C12Q1/68; A61P31/00 | Oldest priority date: 2006-08-04 | Publication date: 2010-09-16

Score: 12.685205 | Text size: 126067 | Find: similardocuments

The ChemDiv compoundsare all combinatorial chemistry based and a large set of analogs are readilyavailable.

PROTEASOME INHIBITORS HAVING CHYMOTRYPSIN-LIKE ACTIVITY

LAWRENCE,Harshani [US]; GE, Yiyu [US]; SEBTI, Said, M.[US];GUIDA, Wayne[US];LAWRENCE,Harshani [US]; GE, Yiyu [US]; SEBTI, Said, M.[US];GUIDA, Wayne[US]

Publicationdate: 2010-09-10 | Patent publication No.: WO-2010102286-A2|Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. [US]; UNIVERSITYOF SOUTH FLORIDA [US] | IPC: A61K31/045; A61K31/41; A61K31/4196; A61K31/38; A61P35/00 | Oldest priority date: 2009-03-06 | Publication date: 2010-09-10

Score: 16.575033 | Text size: 121558 | Find: similardocuments

Theinvention includes a small molecule HLM-008182, identified from 20,000in-house ChemDiv library, was confirmed by in-house synthesisas a proteasome chymotrypsin-like inhibitor. ... proteasome inhibitors, HLM-008182(1 ) (Figure 2) was identified as a 'hit' from a 20,000 in-house ChemDiv librarythat shows potent inhibition against chymotrypsin-like proteasome activity withan IC50

NOVEL PYRROLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISINGTHE SAME

Hiroyuki Kai[JP];Shunji Shinohara[JP];TakayukiKameyama [JP]; Hiroyuki Kai[JP];Shunji Shinohara[JP];TakayukiKameyama [JP]

Publicationdate: 2010-08-19 | Patent publication No.: US-20100210632-A1|Assignees: Hiroyuki Kai [JP]; Shunji Shinohara [JP]; Takayuki Kameyama [JP] | IPC: A61K31/551;C07D413/10; A61K31/42; C07D401/06; A61K31/4439; C07D487/04; C07D413/14;A61K31/5377; A61P19/02 |Oldest priority date: 2007-03-30 | Publicationdate: 2010-08-19

Score: 20.863457 | Text size: 383934 | Find: similardocuments

IFLABF0907-1024 432 I-119 [[image:EMI-C00179]] IFLAB F0908-5466 429 I-120 [[image:EMI-C00180]]ChemDiv C390-0148429 I-121 [[image:EMI-C00181]] ChemDiv C390-0158 426 I-122[[image:EMI-C00182]]ChemDiv C390-0130 399 I-123[[image:EMI-C00183]] ChemDiv C390-0241 364 I-124[[image:EMI-C00184]]ChemDiv C390-0577 350 I-125 [[image:EMI-C00185]] ChemDiv C390-0573346 I-126 [[image:EMI-C00186]]ChemDiv C390-0587 332 I-127[[image:EMI-C00187]] ChemDiv C390-0571 324 I-128[[image:EMI-C00188]]ChemDiv C390-0605 324 I-129[[image:EMI-C00189]] ChemDiv C390-0540 310 I-130[[image:EMI-C00190]]ChemDiv C390-0594 306 I-131[[image:EMI-C00191]] ChemDiv C390-0569 304 I-132[[image:EMI-C00192]]ChemDiv C390-0545 304 I-133[[image:EMI-C00193]] CSC D500050981 297 I-134 [[image:EMI-C00194]]ChemDiv C390-0565

QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS

MALHERBE,Parichehr [CH]; MASCIADRI,Raffaello [CH]; NORCROSS, Roger,David [CH];RATNI, Hasane[FR];THOMAS, Andrew,William [CH]

Publicationdate: 2010-08-11 | Patent publication No.: EP-1809605-B1|Assignees: F. Hoffmann-La Roche AG [CH] | IPC: C07D215/18; C07D215/20; C07D491/04; C07D215/38; C07D401/04; A61K31/4738;A61P25/22 | Oldestpriority date: 2004-11-01 | Publication date: 2010-08-11

Score: 17.021982 | Text size: 104337 | Find: similardocuments

759-768;Synlett 2003, 203-206; Database Chemical Abstracts, database accession no.2002:977034; ChemDiv Inc. Product Library (ChemDiv Inc.,San Diego, CA, USA) order-numbers: 3740-0533, 2085-0043, 2403-0022, 0663-0788,0590-0585,

External link

SUBUNIT SELECTIVE NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OFNEUROLOGICAL CONDITIONS

TRAYNELIS,Stephen, F. [US]; LIOTTA, Dennis,C. [US];MOSLEY, Cara[US];ACKER, Timothy,M. [US];SHELLEY, Sommer[US];TRAYNELIS,Stephen, F. [US]; LIOTTA, Dennis,C. [US];MOSLEY, Cara[US];ACKER, Timothy,M. [US];SHELLEY, Sommer[US]

Publicationdate: 2010-08-05 | Patent publication No.: WO-2010088408-A2|Assignees: EMORY UNIVERSITY [US] | IPC: C07D239/69; A61P19/00; A61P25/16; A61P25/14; A61P25/28; A61P25/04 | Oldest priority date: 2009-01-28 | Publication date: 2010-08-05

Score: 16.413914 | Text size: 196952 | Find: similardocuments

molecules,such as beta-turn mimetic libraries and the like, may be purchased from, forexample, ChemDiv, Pharmacopia or Combichem or synthesized and aredescribed in Tietze and Lieb, Curr. Opin. Chem. ... For example, ChemDiv usesmore than 800 individual chemical cores, a unique Building Block Library, andproprietary ... In addition, ChemDiv's compounds are designed toensure their similarity to drugs adjusted according to proprietary

SUBUNIT SELECTIVE NMDA RECEPTOR POTENTIATORS FOR THE TREATMENT OFNEUROLOGICAL CONDITIONS

TRAYNELIS,Stephen, F. [US]; LIOTTA, Dennis,C. [US];SANTANGELO,Rose, M. [US]; GARNIER, Ethel,C. [US];TRAYNELIS,Stephen, F. [US]; LIOTTA, Dennis,C. [US];SANTANGELO,Rose, M. [US]; GARNIER, Ethel,C. [US]

Score: 16.882145 | Text size: 178013 | Find: similardocuments

molecules,such as beta-turn mimetic libraries and the like, may be purchased from forexample ChemDiv, Pharmacopia or Combichem or synthesized and aredescribed in Tietze and Lieb, Curr. ... For example,ChemDiv usesmore than 800 individual chemical cores, a unique Building Block Library, andproprietary ... In addition, ChemDiv's compounds are designed toensure their similarity to drugs adjusted according to proprietary

UNDERCARBOXYLATED/UNCARBOXYLATED OSTEOCALCIN INCREASES BETA-CELLPROLIFERATION, INSULIN SECRETION, INSULIN SENSITIVITY, GLUCOSE TOLERANCE ANDDECREASES FAT MASS

Gerard Karsenty[US];Patricia F. Ducy[US];Gerard Karsenty[US];Patricia F. Ducy[US]

Publicationdate: 2010-07-29 | Patent publication No.: US-20100190697-A1|Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY IF [US] | IPC: A61K38/16;A61P3/10; A61P3/04; A61P3/14; A61P3/00; C07K14/435; G01N33/68 | Oldest priority date: 2006-09-13 |Publicationdate: 2010-07-29

Score: 8.94598 | Text size: 361302 | Find: similardocuments

METHODS FOR IDENTIFYING INHIBITORS OF SOLUTE TRANSPORTERS

Alan S. Verkman[US];Marc HarrisLevin [US];Alan S. Verkman[US];Marc HarrisLevin [US]

Publicationdate: 2010-07-29 | Patent publication No.: US-20100190796-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/502;C12Q1/02; A61K31/4184 | Oldest prioritydate: 2006-11-16 | Publication date: 2010-07-29

Score: 14.450268 | Text size: 195195 | Find: similardocuments

ALPHA-HELIX MIMETIC USING A 2,5-OLIGOPYRIMIDINE SCAFFOLD

MCLAUGHLIN, MarkL. [US];ANDERSON, Laura[US];ZHOU, Mingzhou[US];MCLAUGHLIN, MarkL. [US];ANDERSON, Laura[US];ZHOU, Mingzhou[US]

Publicationdate: 2010-07-22 | Patent publication No.: WO-2010083501-A2|Assignees: UNIVERSITY OF SOUTH FLORIDA [US]; H. LEE MOFFITT CANCER CENTER AND RESEARCHINSTITUTE, INC. [US] | IPC: C07D403/14; A61K31/435; A61P35/00 | Oldest priority date: 2009-01-16 | Publication date: 2010-07-22

Score: 12.484504 | Text size: 172232 | Find: similardocuments

the chemicaldiversity of the oligopyrimidine library, software such as ChemoSoft (availablefrom ChemDiv, Inc.) or Canvas (currently in beta release from Schrόdinger, LLC)can be employed.

RECEPTOR ACTIVATOR OF THE RANK RECEPTOR COMPLEX INHIBITOR

MURALI,Ramachandran [US]; GREENE, Mark, I.[US];MURALI,Ramachandran [US]; GREENE, Mark, I.[US]

Publicationdate: 2010-07-22 | Patent publication No.: WO-2010083084-A1|Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US] | IPC: A01N43/04;A01N45/00; A61K31/70 | Oldestpriority date: 2009-01-14 | Publication date: 2010-07-22

Score: 15.56228 | Text size: 23940 | Find: similardocuments

The compoundof Formula HI-I was obtained from ChemDiv.

PRO-NEUROGENIC COMPOUNDS

MCKNIGHT,Steven, L. [US]; PIEPER, Andrew,A. [US];READY, Joseph,M. [US];DE BRABANDER,Jef [US];MCKNIGHT,Steven, L. [US]; PIEPER, Andrew,A. [US];READY, Joseph,M. [US];DE BRABANDER,Jef [US]

Publicationdate: 2010-07-15 | Patent publication No.: WO-2010081115-A1|Assignees: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US] | IPC: A61K31/00;A61K31/403; A61K31/415; A61K31/437; A61K31/44; A61K31/506; A61P25/00 | Oldest priority date: 2009-01-09 | Publication date: 2010-07-15

Score: 19.449032 | Text size: 302629 | Find: similardocuments

ol[[image:imgf000135_0003]] Purchased from ChemDiv, Inc. Example59. l-(tert-butylamino)-3-(3,6-dibromo-9H-carbazol-9-yl)propan-2-ol[[image:imgf000136_0001]] Purchased from ChemDiv, Inc. Example60. l-(3,6-dibromo-9H-carbazol-9-yl)-3-(isopropylamino)propan-2-ol[[image:imgf000136_0002]] Purchased fromChemDiv, Inc. Example 61.l-(3,6-dibromo-9H-carbazol-9-yl)-3-(4-methoxyphenylamino)propan- 2-ol[[image:imgf000136_0003]] Purchased from ChemDiv, Inc. Example62. l-(3,6-dibromo-9H-carbazol-9-yl)-3-(3-methoxyphenylamino)propan- 2-ol[[image:imgf000137_0001]] Purchased from ChemDiv, Inc. Example63. l-(3,6-dibromo-9H-carbazol-9-yl)-3-(m-tolylamino)propan-2-ol[[image:imgf000137_0002]] Purchased fromChemDiv, Inc. Example 64.

SCREENING ASSAYS FOR INHIBITORS OF BETA AMYLOID PEPTIDE ION CHANNELFORMATION

Michael Mayer[US];Jerry Yang [US]; Michael Mayer[US];Jerry Yang [US]

Score: 14.039395 | Text size: 70653 | Find: similardocuments

formationand/or activity can be obtained from many suppliers of chemical compounds,including ChemDiv(San Diego, Calif., USA), Sigma-Aldrich (St.Louis, Mo., USA.

Inhibitors of USP1 Deubiquitinating Enzyme Complex

Alan D'Andrea[US];Alan D'Andrea[US]

Score: 11.918776 | Text size: 155127 | Find: similardocuments

consists ofknown bioactive libraries, natural product libraries, and commercial librariessuch as ChemDiv, ChemBridge etc.

High throughput screening assay for the TRPM5 ion channel

Robert W. Bryant[US];S. Paul Lee [US]; R. Kyle Palmer[US];Qifeng Yang [US]; M. N. Tulu Buber[US];Robert W. Bryant[US];S. Paul Lee [US]; R. Kyle Palmer[US];Qifeng Yang [US]; M. N. Tulu Buber[US]

Score: 14.039395 | Text size: 81196 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS)

Agnes BOMBRUN[FR];Patrick Gerber[CH];Dennis Church[CH];Agnes BOMBRUN[FR];Patrick Gerber[CH];Dennis Church[CH]

Publicationdate: 2010-07-01 | Patent publication No.: US-20100168101-A1|Assignees: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. [NL] | IPC: A61K31/5377;A61K31/404; C07D209/40; C07D413/12; A61K31/4245; C07D405/12; A61K31/427;C07D417/14; C07D401/12; A61K31/4439; A61P3/10 | Oldest priority date: 2001-10-30 | Publication date: 2010-07-01

Score: 10.089907 | Text size: 270097 | Find: similardocuments

a), b), e),f) and g) are commercially available from catalogues of ChemDiv.

SMALL MOLECULE INHIBITION OF INTRACELLULAR TRANSPORT

David B. Haslam[US];David B. Haslam[US]

Publicationdate: 2010-06-24 | Patent publication No.: US-20100159468-A1|Assignees: THE WASHINGTON UNIVERSITY [US] | IPC:C12Q1/68;C12N5/07; C12N5/071; C07H21/00; C12N15/74 | Oldest priority date: 2008-12-23 | Publication date: 2010-06-24

Score: 18.541523 | Text size: 119323 | Find: similardocuments

ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

William J. Welsh[US];Nina Ching Y.Wang [US];Ni Ai [US]; William J. Welsh[US];Nina Ching Y.Wang [US];Ni Ai [US]

Publicationdate: 2010-06-17 | Patent publication No.: US-20100152271-A1|Assignees: UNIVERSIT OF MEDICINE AND DENISTRY OF NEW JERSEY [US] | IPC: A61K31/4035;A61K31/122; A61P19/10; A61P9/10; A61P35/00; A61P25/28; A61P3/00; C07C49/175;C07D209/48; G01N33/53 | Oldestpriority date: 2006-07-06 | Publication date: 2010-06-17

Score: 17.30191 | Text size: 48905 | Find: similardocuments

ALPHAVIRUS INHIBITORS AND USES THEREOF

David J. Miller[US];Daniel C.Peltier [US]; Weiping Peng[US];David J. Miller[US];Daniel C.Peltier [US]; Weiping Peng[US]

Publicationdate: 2010-06-17 | Patent publication No.: US-20100152200-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US] | IPC: A61K31/496;C07D495/04; A61K31/454; C07D401/14; A61P31/12 | Oldest priority date: 2008-11-17 | Publication date: 2010-06-17

Score: 14.039395 | Text size: 72501 | Find: similar documents

libraryconsisted of compounds from four smaller collections: Chembridge (13,028compounds), ChemDiv(20,000 compounds), Maybridge (16,000compounds), and MS Spectrum 2000 (2,000 compounds), the

ASSAYS FOR IDENTIFYING GENES ENCODING SALTY TASTE RECEPTORS ANDMODULATORS

MOYER, Bryan[US];ZLOTNIK, Albert[US];HEVEZI, Peter[US];SOTO, Hortensia[US];LU, Min [US]; GAO, Na [US]; SAGANICH,Michael [US];DAHAN, Michael[US];LAITA, Bianca[US];SERVANT, Guy[US];BRUST, Paul [US]; WILLIAMS, Mark[US];MOYER, Bryan[US];ZLOTNIK, Albert[US];HEVEZI, Peter[US];SOTO, Hortensia[US];LU, Min [US]; GAO, Na [US]; SAGANICH,Michael [US]; DAHAN, Michael[US];LAITA, Bianca[US];SERVANT, Guy[US];BRUST, Paul [US]; WILLIAMS, Mark[US]

Score: 7.874651 | Text size: 422665 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma- Aldrich (St.Louis, Mo.

COMPOUNDS THAT INHIBIT HUMAN DNALIGASES AND METHODS OF TREATING CANCER

Alan E.TOMKINSON [US]; Xi CHEN [US]; BarbaraDZIEGIELEWSKA [US]; Alexander D.MACKERELL [US]; Shijun ZHONG[US];Gerald M. Wilson[US];Alan E.TOMKINSON [US]; Xi CHEN [US]; BarbaraDZIEGIELEWSKA [US]; Alexander D.MACKERELL [US]; Shijun ZHONG[US];Gerald M. Wilson[US]

Publicationdate: 2010-04-22 | Patent publication No.: US-20100099683-A1|Assignees: Alan E. TOMKINSON [US]; Xi CHEN [US]; Barbara DZIEGIELEWSKA [US]; AlexanderD. MACKERELL [US]; Shijun ZHONG [US]; Gerald M. Wilson [US] | IPC: A61K31/519;C12Q1/68; C12N5/00; A61K31/50; A61K31/506; A61K31/505; A61K31/44; A61K31/437;A61K31/4245; A61K31/428; A61K31/4196; A61K31/404; A61K31/381; A61K31/341;A61K31/165; A61P35/00 | Oldestpriority date: 2007-04-10 | Publication date: 2010-04-22

Score: 12.685205 | Text size: 149601 | Find: similardocuments

Compoundsidentified by CADD screening were purchased from ChemBridge, ChemDiv,MayBridge, MDD, Nanosyn, Specs, Timtec, and Tripos.

COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGENPROTEINS

Brett Tyler [US]; Daolong Dou [CN]; Shiv Kale [US]; Biao Gu [CN]; Brett Tyler [US]; Daolong Dou [CN]; Shiv Kale [US]; Biao Gu [CN]

Publicationdate: 2010-04-15 | Patent publication No.: US-20100093601-A1|Assignees: Brett Tyler [US]; Daolong Dou [CN]; Shiv Kale [US]; Biao Gu [CN] | IPC: A61K38/02;A61K31/661; A61K31/255 | Oldestpriority date: 2008-05-19 | Publication date: 2010-04-15

Score: 12.290053 | Text size: 149321 | Find: similardocuments

COMPOSITIONS AND METHODS FOR TREATING ALCOHOL USE DISORDERS, PAIN ANDOTHER DISEASES

WU, JayJie-Quiang [US]; WU, JayJie-Quiang [US]

Publicationdate: 2010-04-15 | Patent publication No.: WO-2010042925-A2|Assignees: WU, Jay Jie-Quiang [US] | IPC: C07D401/14; C07D401/02; C07D279/14; C07D241/40; C07D487/04; C07D265/36;C07D498/04; A61K31/4162; A61P35/00 | Oldestpriority date: 2008-10-10 | Publication date: 2010-04-15

Score: 10.928354 | Text size: 213284 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (SanDiego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, The Netherlands),Timtec (Newark, DE) or can be synthesized.

Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs)

Agnes Bombrun[FR];Patrick Gerber[CH];Denis Church[CH];Agnes Bombrun[FR];Patrick Gerber[CH];Denis Church[CH]

Score: 10.354719 | Text size: 277060 | Find: similardocuments

a), b), e),f) and g) are commercially available from catalogues of ChemDiv.

Compounds having activity in increasing ion transport by mutant-CFTR anduses thereof

Alan Verkman[US];Luis J. V.Galietta [US]; R. Kiplin Guy[US];Alan Verkman[US];Luis J. V.Galietta [US]; R. Kiplin Guy[US]

Score: 12.685205 | Text size: 128883 | Find: similardocuments

>1000analogs of the compounds identified in the primary screen were purchased fromChemBridge orChemDiv (out of ̃600,000 available compounds) orsynthesized/purified.

HEME OXYGENASE INHIBITORS, SCREENING METHODS FOR HEME OXYGENASEINHIBITORS AND METHODS OF USE OF HEME OXYGENASE INHIBITORS FOR ANTIMICROBIALTHERAPY

Angela Wilks[US];AlexanderMacKerrel, JR. [US]; Lena Furci [US]; Pedro Lopes [US]; Angela Wilks[US];AlexanderMacKerrel, JR. [US]; Lena Furci [US]; Pedro Lopes [US]

Publicationdate: 2010-04-01 | Patent publication No.: US-20100081661-A1|Assignees: UNIVERSITY OF MARYLAND, BALTIMORE [US] |IPC: A61K31/53; A61K31/444; A61K31/403; A61K31/405; A61K31/195; A61K31/155;A61K31/135 | Oldestpriority date: 2006-07-24 |Publicationdate: 2010-04-01

Score: 20.777588 | Text size: 156138 | Find: similardocuments

Chemicaldiversity compounds Compound ID Formula MW Solvent Solubility Km (uM) E. coliAssay ChemDiv 1 0091-0260 C16H11N3O6 341.2826 EtOH I — — ChemDiv 20139-0251 C10H7NO4 205.1716 EtOH S + —ChemDiv 3 0173-0031 C9H11N4O3223.213 EtOH I — — ChemDiv 4 0812-1008 C15H8N2O3 264.2426 EtOHI — — ChemDiv 5 1300-0270 C10H10N2O2 190.2034 EtOH S — — ChemDiv 61824-0926 C10H9FN4O2 236.2072 EtOH I — — ChemDiv 7 1988-0303C12H10N6O5 318.2507 EtOH I — — ChemDiv 8 2181-0037 C18H16N4O304.3544 EtOH I — — ChemDiv 9 2226-0401 C10H11N3O2 205.2181EtOH S — —ChemDiv 10 2825-0171 C15H11NO3 253.2598 EtOH I — — ChemDiv 114335-0782 C15H11N3O3 281.2732 EtOH I — — ChemDiv 12 4696-0935C12H14O4 222.243 EtOH S + — ChemDiv 13 8005-4121 C13H13NO3231.2535 MeOH S + — ChemDiv 14 8010-0630 C14H13Cl2NO 282.

NOVEL OXINDOLE DERIVATIVE

Noriaki Shinobu[JP];Jun Shao [JP]; MasatakaKobayashi [JP]; Takao Mori [JP]; Noriaki Shinobu[JP];Jun Shao [JP]; MasatakaKobayashi [JP]; Takao Mori [JP]

Score: 13.793969 | Text size: 71469 | Find: similardocuments

compoundswere searched from a serine/threonine kinase inhibitory compound library(available fromChemDiv). Based on the information of correlation ofstructural activity of the obtained candidate

SYNAPTIC VESICLE CYCLING ASSAYS AND SYSTEMS

GERBER, David,J. [US];COTTRELL,Jeffrey, R. [US]; RYAN, Timothy,A. [US];LEVENSON,Jonathan, M. [US]; GERBER, David,J. [US];COTTRELL,Jeffrey, R. [US]; RYAN, Timothy,A. [US];LEVENSON,Jonathan, M. [US]

Score: 13.939713 | Text size: 306147 | Find: similardocuments

Screening assay for inhibitors of TRPA1 activation by a lower alkyl phenol

Seunghun PaulLee [US];Qifeng Yang [US]; Robert W. Bryant[US];Tulu Buber [US]; Seunghun PaulLee [US];Qifeng Yang [US]; Robert W. Bryant[US];Tulu Buber [US]

Score: 13.327991 | Text size: 99315 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

METHODS OF IDENTIFYING FUNCTIONAL CHARACTERISTICS OF PROMOTERS,TRANSCRIPTION MODIFYING PROTEINS AND TRANSCRIPTION MODULATING AGENTS

JONKER, Johan,W. [US];DOWNES, Michael[US];EVANS, Ronald,M. [US];JONKER, Johan,W. [US];DOWNES, Michael[US];EVANS, Ronald,M. [US]

Score: 11.239684 | Text size: 214184 | Find: similardocuments

(San Diego,CA) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, CA) providing a variety ofcompound diversity libraries including CombiLab and the

METHODS FOR IDENTIFYING OR ASSAYING FOR AGENTS THAT INCREASE BETA-CELLPROLIFERATION, INSULIN SECRETION, INSULIN SENSITIVITY, GLUCOSE TOLERANCE ANDDECREASE FAT MASS

Gerard Karsenty[US];Patricia F. Ducy[US];Gerard Karsenty[US];Patricia F. Ducy[US]

Score: 8.94598 | Text size: 366455 | Find: similardocuments

Compounds, Compositions and Methods for Treating Hormone-DependentMaladies

Kurtis E.Bachman [US]; Ben Ho Park [US]; Kurtis E.Bachman [US]; Ben Ho Park [US]

Publicationdate: 2010-02-25 | Patent publication No.: US-20100048523-A1|Assignees: Kurtis E. Bachman [US]; Ben Ho Park [US] | IPC:A61K31/58; A61P35/00; A61P15/00; A61P15/18 | Oldest priority date: 2006-04-07 | Publication date: 2010-02-25

Score: 14.831028 | Text size: 40469 | Find: similardocuments

Approximately40,000 diverse small molecules are obtained from ChemDiv, Inc. (SanDiego, Calif.

STAT3 INHIBITORS

David J. Tweardy[US];Xuejun Xu [US]; Moses M.Kasembeli [US]; David J. Tweardy[US];Xuejun Xu [US]; Moses M.Kasembeli [US]

Publicationdate: 2010-02-18 | Patent publication No.: US-20100041685-A1|Assignees: David J. Tweardy [US]; Xuejun Xu [US]; Moses M. Kasembeli [US] | IPC: A61K31/505;A61K31/357; A61K31/427; A61K31/195; A61P35/00; A61P11/00; A61P1/00; A61K31/366|Oldestpriority date: 2008-06-04 | Publication date: 2010-02-18

Score: 14.719831 | Text size: 223943 | Find: similardocuments

THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES

Robert P.RICCIARDI [US]; Robert P.RICCIARDI [US]

Publicationdate: 2010-02-11 | Patent publication No.: US-20100035887-A1|Assignees: Robert P. RICCIARDI [US] | IPC: A61K31/4985; A61K31/497; A61K31/519; A61K31/429; A61K31/427 | Oldest priority date: 2007-02-06 | Publication date: 2010-02-11

Score: 17.610455 | Text size: 170537 | Find: similardocuments

Inhibitors of Cyclic Nucleotide Synthesis and Their Use for Therapy ofVarious Diseases

Richard L.Guerrant [US]; Alexander Y.Kots [US];Ferid Murad [US]; Byung-Kwon Choi[US];Richard L.Guerrant [US]; Alexander Y.Kots [US];Ferid Murad [US]; Byung-Kwon Choi[US]

Publicationdate: 2010-02-11 | Patent publication No.: US-20100035867-A1|Assignees: Richard L. Guerrant [US]; Alexander Y. Kots [US]; Ferid Murad [US];Byung-Kwon Choi [US] | IPC: A61K31/5415; A61K31/519 | Oldestpriority date: 2006-07-11 | Publication date: 2010-02-11

Score: 13.793969 | Text size: 71296 | Find: similardocuments

Thecompounds were purchased from ChemDiv, Inc., San Diego, Calif.

INHIBITORS OF THE PLASMODIAL SURFACE ANION CHANNEL AS ANTIMALARIALS

DESAI, Sanjay,A. [US];PILLAI, Ajay, D.[US];DESAI, Sanjay,A. [US];PILLAI, Ajay, D.[US]

Publicationdate: 2010-01-28 | Patent publication No.: WO-2010011537-A1|Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENTOF HEALTH AND HUMAN SERVICES [US] | IPC: A61K31/554; A61K31/165; A61K31/421; A61K31/4245; A61K31/433; A61K31/4355;A61K31/437; A61P33/06 | Oldestpriority date: 2008-07-23 | Publication date: 2010-01-28

Score: 14.039395 | Text size: 73991 | Find: similardocuments

methods aswould be known to those skilled in the art or obtained from commercial sourcessuch as ChemDiv Inc., San Diego, CA or Peakdale Molecular Limited,High Peak, England.

WNT pathway antagonists

Philip A. Beachy[US];James K. Chen[US];Ronald K. Mann[US];Philip A. Beachy[US];James K. Chen[US];Ronald K. Mann[US]

Score: 12.290053 | Text size: 128647 | Find: similardocuments

format and,using pin transfers on Biomek FX robotics (Beckman), we screened 40,000compounds fromChemDiv and ChemBridge collections (at aconcentration of approx.

PRRG4-ASSOCIATED COMPOSITIONS AND METHODS OF USE THEREOF IN METHODS OFTUMOR DIAGNOSIS

Katherine A.High [US];Fayaz R. Khazi[US];Kirk Chu [US]; Luca Monaldini[IT];Mustafa NaciYazicioglu [US]; Samuel Murphy[US];Katherine A.High [US];Fayaz R. Khazi[US];Kirk Chu [US]; Luca Monaldini[IT];Mustafa NaciYazicioglu [US]; Samuel Murphy[US]

Publicationdate: 2010-01-21 | Patent publication No.: US-20100017897-A1|Assignees: Katherine A. High [US]; Fayaz R. Khazi [US]; Kirk Chu [US]; Luca Monaldini[IT]; Mustafa Naci Yazicioglu [US]; Samuel Murphy [US] | IPC: A01K67/027;C12Q1/68; C12Q1/02; G01N33/53; C40B30/04; G01N33/68; A61K31/7088 | Oldest priority date: 2006-12-08 | Publication date: 2010-01-21

Score: 13.556976 | Text size: 91570 | Find: similardocuments

Austria),BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (San Diego,Calif.), ChemDiv, (San Diego, Calif.

METHODS FOR TREATING ARTHRITIS AND OTHER INFLAMMATORY OR AUTOIMMUNEDISEASES

GELB, Michael,H. [US];LEE, David, M.[US];LAMBEAU, Gerard[FR];BALESTRIERI,Barbara [US]; BOILARD, Eric[US];ARM, Jonathan,P. [US];GELB, Michael,H. [US];LEE, David, M.[US];LAMBEAU, Gerard[FR];BALESTRIERI,Barbara [US]; BOILARD, Eric[US];ARM, Jonathan,P. [US]

Publicationdate: 2010-01-21 | Patent publication No.: WO-2010009403-A2|Assignees: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US]; UNIVERSITY OF WASHINGTON [US]|IPC: A61K38/46 | Oldestpriority date: 2008-07-18 | Publication date: 2010-01-21

Score: 11.569273 | Text size: 214097 | Find: similardocuments

vendors suchas ChemBridge Libraries (www.chembridge.com), BIOMOL International,ASINEX, ChemDiv, ChemDB, ICCB- Longwood.

METHOD FOR EVOLVING MOLECULES AND COMPUTER PROGRAM FOR IMPLEMENTING THESAME

Hans Louis JosDe Winter [BE]; Wilfried GertRoger Langenaeker [BE]; Hans Louis JosDe Winter [BE]; Wilfried GertRoger Langenaeker [BE]

Score: 14.165414 | Text size: 135804 | Find: similardocuments

2,224 549Asinex 372,703 127,963 Aurora Feinchemie 1,019,555 305,231 ChemBridge 482,993200,666ChemDiv 605,230 207,539 Cerep 29,231 10,179 CMC 8,757 2,657ChemStar 60,260 15,128 Chem T&I 323,127

Inhibitors for Extracellular Signal-Regulated Kinase Docking Domains and UsesTherefor

Paul Shapiro[US];Alexander D.MacKerell, JR. [US]; Paul Shapiro[US];Alexander D.MacKerell, JR. [US]

Publicationdate: 2009-12-03 | Patent publication No.: US-20090299063-A1|Assignees: Paul Shapiro [US]; Alexander D. MacKerell, JR. [US] | IPC: C07D413/12;C07D417/04; C07D265/30; C07D241/04 | Oldestpriority date: 2005-03-29 | Publication date: 2009-12-03

Score: 13.327991 | Text size: 100323 | Find: similardocuments

Compounds17, 36, 67-68, 76, and 79-81 selected via CADD were purchased from ChemDiv (SanDiego, Calif.) or ChenBridge (San Diego, Calif.

COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGENPROTEINS

KALE, Shiv [US]; TYLER, Brett[US];DOU, Daolong[US];KALE, Shiv [US]; TYLER, Brett[US];DOU, Daolong[US]

Publicationdate: 2009-11-26 | Patent publication No.: WO-2009143133-A2|Assignees: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. [US] | IPC: A61K31/6615;A61K38/02; C07K14/44; G01N33/68; A61P31/00 | Oldest priority date: 2008-05-19 | Publication date: 2009-11-26

Score: 12.290053 | Text size: 149223 | Find: similardocuments

COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF CANCER

WIEST, David[US];LOOK, A., Thomas[US];WIEST, David[US];LOOK, A., Thomas[US]

Publicationdate: 2009-11-26 | Patent publication No.: WO-2009143239-A1|Assignees: FOX CHASE CANCER CENTER [US]; DANA-FARBER CANCER INSTITUTE, INC. [US] | IPC: C12Q1/68;C12P19/34 | Oldestpriority date: 2008-05-20 | Publication date: 2009-11-26

Score: 14.039395 | Text size: 76107 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

ASTHMA SUSCEPTIBILITY LOCI LOCATED AT CHROMOSOME 1q31 FOR USE INDIAGNOSTIC AND THERAPEUTIC METHODS

HAKONARSON,Hakon [US];SLEIMAN,Patrick, M., A. [US]; HAKONARSON,Hakon [US];SLEIMAN,Patrick, M., A. [US]

Score: 13.556976 | Text size: 115584 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

GENETIC ALTERATIONS ON CHROMOSOMES 21Q, 6Q AND 15Q AND METHODS OF USETHEREOF FOR THE DIAGNOSIS AND TREATMENT OF TYPE I DIABETES

HAKONARSON,Hakon [US];GRANT, Struan[US];BRADFIELD,Jonathan [US]; POLYCHRONAKOS,Constantin [CA]; QU, Hui-Qi [CA]; HAKONARSON,Hakon [US];GRANT, Struan[US];BRADFIELD,Jonathan [US]; POLYCHRONAKOS,Constantin [CA]; QU, Hui-Qi [CA]

Publicationdate: 2009-11-19 | Patent publication No.: WO-2009140679-A2|Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US]; THE ROYAL INSTITUTION FOR THEADVANCEMENT OF LEARNING/McGILL UNIVERSITY [CA] | IPC: G01N33/48 | Oldest priority date: 2008-05-16 | Publication date: 2009-11-19

Score: 13.327991 | Text size: 128218 | Find: similardocuments

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX

EMERT-SEDLAK,Lori [US];KODAMA, Toshiaki[JP];DAY, Billy, W.[US];DAI, Weixiang[CN];TRIBLE, Ronald,P. [US];SMITHGALL,Thomas, E. [US];EMERT-SEDLAK,Lori [US];KODAMA, Toshiaki[JP];DAY, Billy, W.[US];DAI, Weixiang[CN];TRIBLE, Ronald,P. [US];SMITHGALL,Thomas, E. [US]

Publicationdate: 2009-11-19 | Patent publication No.: WO-2009139886-A2|Assignees: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION[US] |IPC: C07D241/44; C07D241/40; A61K31/498; A61P31/18 | Oldest priority date:2008-05-14 | Publication date: 2009-11-19

Score: 18.761955 | Text size: 98510 | Find: similardocuments

Carlsbad,CA) as described by Trible et al. (Id.) Chemical libraries were purchasedfrom ChemDiv, Inc. (San Diego, CA) and include a kinase-directedlibrary (2500 compounds), a phosphatase directed ... μL) wereplated in duplicate wells of a 96-well plate in the presence of each compoundfrom the ChemDiv kinase-biased inhibitor library (ChemDiv,Inc., San Diego, CA). All compounds were initially screened at 10 μM with 0.5%DMSO as carrier solvent. ... observed with A-419259 were obtained in powderform from the provider of the original library (ChemDiv) and assayed athird time in triplicate at 1, 3, 10, and 30 μM in comparison with 5 μM A-419259.

GENETIC ALTERATIONS ON CHROMOSOMES 21Q, 6Q AND 15Q AND METHODS OF USETHEREOF FOR THE DIAGNOSIS AND TREATMENT OF TYPE I DIABETES

Publicationdate: 2009-11-19 | Patent publication No.: WO-2009140679-A9|Assignees: THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US]; THE ROYAL INSTITUTION FOR THEADVANCEMENT OF LEARNING/McGILL UNIVERSITY [CA] | IPC: G01N33/48 | Oldest priority date: 2008-05-16 | Publication date: 2009-11-19

Score: 13.327991 | Text size: 134058 | Find: similar documents

(Graz,Austria), BioFocus DPI, Switzerland, Bionet (Camelford, UK), ChemBridge, (SanDiego, CA), ChemDiv, (San Diego, CA), Chemical Block Lt, (Moscow,Russia), ChemStar (Moscow, Russia), Exclusive

ASSAY USING TRPML3 (MCOLN3) SALTY TASTE RECEPTOR AND USE IN IDENTIFYINGTASTE (SALTY) MODULATORS

SERVANT, Guy[US];BRUST, Paul [US]; WILLIAMS, Mark[US];SERVANT, Guy[US];BRUST, Paul [US]; WILLIAMS, Mark[US]

Score: 8.202065 | Text size: 445338 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma -Aldrich (St.Louis, Mo.

METHODS OF INHIBITING OSTEOCLAST ACTIVITY

MURALI,Ramachandran [US]; GREENE, Mark, I.[US];KINOSAKI,Masahiko [JP]

Publicationdate: 2009-11-18 | Patent publication No.: EP-1207873-B1|Assignees: The Trustees of The University of Pennsylvania [US] |IPC: A61K31/195; A61K31/235; A61K31/56; A61K45/06; A61K31/05; A61K31/02;A61K31/06; A61K31/055; A61K31/085 | Oldestpriority date:1999-07-28 | Publication date: 2009-11-18

Score: 19.22352 | Text size: 99364 | Find: similardocuments

entitledFormulae and are described in the table below which includes catalogue numbersfrom ChemDiv, Inc., San Diego, CA. ... entitled Formulae and aredescribed in the table below which includes catalogue numbers from ChemDiv,Inc., San Diego, CA. ... entitled Formulae and are described in the tablebelow which includes catalogue numbers from ChemDiv, Inc., SanDiego, CA. ... entitled Formulae and are described in the table below whichincludes catalogue numbers from ChemDiv, Inc., San Diego, CA. ...of Formulae VIII to XII and are described in the table below which includescatalogue numbers from ChemDiv, Inc., San Diego, CA.

External link

COMPOUNDS THAT MODULATE NEGATIVE-SENSE, SINGLE-STRANDED RNA VIRUSREPLICATION AND USES THEREOF

SHAW, Megan, L.[US];HOFFMANN,Hans-Heinrich [US]; GARCIA-SASTRE,Adolfo [US];PALESE, Peter[US];SHAW, Megan, L.[US];HOFFMANN,Hans-Heinrich [US]; GARCIA-SASTRE,Adolfo [US];PALESE, Peter[US]

Publicationdate: 2009-11-12 | Patent publication No.: WO-2009136979-A2|Assignees: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY [US] | IPC: A61K31/00;A61K31/4245; A61P31/16 | Oldestpriority date: 2008-03-06 | Publication date: 2009-11-12

Score: 18.17824 | Text size: 385824 | Find: similardocuments

includedAsinex 1 - (12,378 compounds screened out of 12,378) by ASINEX, Winston-Salem,NC; ChemDiv 3 - (1,760 compounds screened out of 16,544)by ChemDiv Inc., San Diego, CA; ChemDiv 4 -(14,677 compounds screened out of 14,677) by ChemDiv Inc., SanDiego, CA; ChemDiv 5 - (1,249 compounds screened out of 1,249)by ChemDiv Inc., San Diego, CA; ENAMINE 2 - (352 compounds screenedout of 26,576) by ENAMINE Ltd. ... 13), NDV (Fig. 14A) and VSV (Fig. 14B).[00438] Lead compound C2 was identified in a screen of theChemDiv 4source library (14,677 compounds; ChemDiv Inc., San Diego, CA,USA).

SCREEN FOR INHIBITORS OF HIV REPLICATION

BRUCE, James, W.[US];AHLQUIST, Paul,G. [US];YOUNG, John, A.T. [US];BRUCE, James, W.[US];AHLQUIST, Paul,G. [US];YOUNG, John, A.T. [US]

Publicationdate: 2009-11-05 | Patent publication No.: WO-2009134988-A1|Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION [US]; THE SALK INSTITUTE FORBIOLOGICAL STUDIES [US] | IPC: G01N33/68 | Oldestpriority date: 2008-05-02 | Publication date: 2009-11-05

Score: 13.327991 | Text size: 108996 | Find: similardocuments

Othersuitable groups of compounds would include the Chembridge collection (16,000compounds), ChemDivcollection (20,000 compounds), and the NCI opencollection (140,000 compounds).

EPIGENETIC SILENCING OF TUMOR SUPPRESSOR GENES

WITCHER, Michael[US];EMERSON,Beverly, M. [US]; WITCHER, Michael[US];EMERSON,Beverly, M. [US]

Publicationdate: 2009-11-05 | Patent publication No.: WO-2009134420-A2|Assignees: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES [US] | IPC: G01N33/68;C07K14/435; G01N33/574; A61K38/17 | Oldestpriority date: 2008-05-01 | Publication date: 2009-11-05

Score: 10.089907 | Text size: 271665 | Find: similardocuments

(San Diego,CA) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, CA) providing a variety ofcompound diversity libraries including CombiLab and the

Prostaglandin EP4 antagonists

Larry A. Wheeler[US];Michael E. Garst[US];Yanbin Liang[US];David F.Woodward [US]; Achim H.-P.Krauss [US];Robert M. Burk[US];Yariv Donde [US]; Mark Holoboski[US];David W. Old[US];June Chen [US]; Larry A. Wheeler[US];Michael E. Garst[US];Yanbin Liang[US];David F.Woodward [US]; Achim H.-P.Krauss [US];Robert M. Burk[US];Yariv Donde [US]; Mark Holoboski[US];David W. Old[US];June Chen [US]

Score: 15.410318 | Text size: 25167 | Find: similardocuments

Thesecompounds can be purchased from several companies including ChemDiv.

METHODS OF TREATING FUNGAL INFECTIONS

LEWIS, Kim [US]; LAFLEUR,Michael, David [US]; LEWIS, Kim [US]; LAFLEUR,Michael, David [US]

Publicationdate: 2009-10-29 | Patent publication No.: WO-2009132101-A1|Assignees: NORTHEASTERN UNIVERSITY [US] | IPC:A61K31/13;A61K31/4015; A61K31/4164; A61K31/496; A61P31/10 | Oldest priority date: 2008-04-22 | Publication date: 2009-10-29

Score: 12.290053 | Text size: 135626 | Find: similardocuments

the NationalInstitutes of Health Molecular Library Screening Center, The ChemBridgeLibrary, the ChemDivLibrary, and the MayBridge Library.

HIGH-THROUGHPUT CELL-BASED CFTR ASSAY

GARDENER,Matthew, James [GB]; SHEARER, Joanne,Lesley [GB];CRONK, David,William [GB]; GARDENER,Matthew, James [GB]; SHEARER, Joanne,Lesley [GB];CRONK, David,William [GB]

Score: 14.424358 | Text size: 58997 | Find: similardocuments

They can besynthesized de novo or purchased from a supplier such as ChemDiv (SanDiego, Calif), Sigma-Aldrich (St. Louis, Mo.

High-Throughput Cell-Based CFTR Assay

Matthew JamesGardener [GB]; Joanne LesleyShearer [GB]; David WilliamCronk [GB];Matthew JamesGardener [GB]; Joanne LesleyShearer [GB]; David WilliamCronk [GB]

Score: 14.424358 | Text size: 56260 | Find: similardocuments

They can besynthesized de novo or purchased from a supplier such as ChemDiv (SanDiego, Calif.), Sigma-Aldrich (St. Louis, Mo.

COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY

Aleksey G.Kazantsev [US]; Aleksey G.Kazantsev [US]

Score: 12.484504 | Text size: 136766 | Find: similardocuments

Sourcesinclude Asinex (Moscow, Russia); Bionet (Camelford, England); ChemDiv (SanDiego, Calif.

Mammalian sour/acid taste and CSF receptor genes, polypeptides and assays

Charles Zuker[US];Angela L. Huang[US];Charles Zuker[US];Angela L. Huang[US]

Score: 10.633806 | Text size: 264278 | Find: similardocuments

(San Diego,Calif.) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, Calif.

USE OF A POLYPHENOLIC TYPE COMPOUND FOR PREVENTING OR TREATING APOLYGLUTAMINE EXPANSION NEURODEGENERATIVE DISEASE

NERI, Christian[FR];NERI, Christian[FR]

Publicationdate: 2009-10-01 | Patent publication No.: WO-2009118338-A2|Assignees: INSERM (Institut National de la Santé et de la RechercheMédicale) [FR] | IPC: A61K31/085; A61K31/09; A61K31/353; A61K31/7004; A61K31/7048; A61P25/28 | Oldest priority date: 2008-03-27 | Publication date: 2009-10-01

Score: 14.971729 | Text size: 46480 | Find: similardocuments

providers ofchemical compounds, including companies like, for example, Cerep (Paris,France), Chemdiv Inc.(San Diego, United States), Chembridge (SanDiego, United States), Maybridge subsidiary of Thermo

Methods and compositions for diagnosis and treatment of influenza

Peter S. Lu [US]; Michael P.Belmares [US]; Dave Garman [US]; Peter S. Lu [US]; Michael P.Belmares [US]; Dave Garman [US]

Score: 9.370946 | Text size: 368863 | Find: similardocuments

software(Accelrys, San Diego, Calif.) was used to model and dock a 650,000 moleculelibrary (ChemDiv, San Diego, Calif.; Blanca Pharmaceuticals, MountainView, Calif.

ANTI-BACTERIAL DRUG TARGETING OFGENOME MAINTENANCE INTERFACES

James L. Keck[US];Douglas A.Bernstein [US]; James L. Keck[US];Douglas A.Bernstein [US]

Publicationdate: 2009-08-13 | Patent publication No.: US-20090203754-A1|Assignees: James L. Keck [US]; Douglas A. Bernstein [US] |IPC: A61K31/427; G01N33/566; G01N33/573; A61P31/00; C12N9/99; G06G7/50 | Oldest priority date: 2007-05-22 | Publication date: 2009-08-13

Score: 10.633806 | Text size: 580038 | Find: similardocuments

Calif.), fromthe Maybridge HitFinder library (Thermo Fisher Scientific, Waltham, Mass.),from the ChemDivlibrary (Chemical Diversity Labs, San Diego,Calif.), or from the Known Bioactive Library—KBA01.

ANTI-ANGIOGENIC COMPOUNDS

HUANG, Danzhi[CH];KOLB, Peter [AT]; NEVADO, Cristina[CH];CAFLISCH, Amedeo[CH];LAFLEUR, Karine[CH];HUANG, Danzhi[CH];KOLB, Peter [AT]; NEVADO, Cristina[CH];CAFLISCH, Amedeo[CH];LAFLEUR, Karine[CH]

Score: 12.685205 | Text size: 120713 | Find: similardocuments

example,three libraries were combined for a total of 728'202 compounds: the NCIdatabase, the ChemDivlibrary (Moscow, Russia) and the synthetic andnatural compound library of InterBioScreen (Moscow,

Methods of inhibiting osteoclast activity

Mark I. Greene[US];RamachandranMurali [US];MasahikoKinosaki [JP]; Mark I. Greene[US];RamachandranMurali [US];MasahikoKinosaki [JP]

Publicationdate: 2009-07-28 | Patent publication No.: US-07566741-B2|Assignees: The Trustees of the University of Pennsylvania [US] |IPC: A61K31/05; A61K31/03; A61K31/085; A61K31/131; A61P19/08; A61P19/10 | Oldest priority date: 2003-07-22 | Publication date: 2009-07-28

Score: 19.317642 | Text size: 87460 | Find: similardocuments

entitledFormulae and are described in the table below which includes catalogue numbersfrom ChemDiv, Inc., San Diego, Calif. ... entitled Formulae and aredescribed in the table below which includes catalogue numbers from ChemDiv,Inc., San Diego, Calif. ... entitled Formulae and are described in thetable below which includes catalogue numbers from ChemDiv, Inc.,San Diego, Calif. ... entitled Formulae and are described in the table belowwhich includes catalogue numbers from ChemDiv, Inc., San Diego,Calif. ... of Formulae VIII to XII and are described in the table below whichincludes catalogue numbers from ChemDiv, Inc., San Diego, Calif.

ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7

WELLS, Jim [US]; RENSLO, Adam R.[US];WOLAN, Dennis[US];ZORN, Julie [US]; WELLS, Jim [US]; RENSLO, Adam R.[US];WOLAN, Dennis[US];ZORN, Julie [US]

Score: 13.4640045 | Text size: 274935 | Find: similardocuments

The smallmolecule HTS libraries screened included approximately 12,000 compounds fromthe ChemDivDiversity set, 10,000 compounds from the ChemDiv Kinaselibrary and 40,000 small molecules from a custom library housed at UCSF in theSMDC.

Non-Peptidic Inhibitors of AKAP/PKA Interaction

Enno Klussmann[DE];Walter Rosenthal[DE];Jorg Rademann[DE];Frank Christian[DE];Sina Meyer [DE]; Enno Klussmann[DE];Walter Rosenthal[DE];Jorg Rademann[DE];Frank Christian[DE];Sina Meyer [DE]

Publicationdate: 2009-07-09 | Patent publication No.: US-20090176773-A1|Assignees: FORSCHUNGSVERBUND BERLIN E.V. [DE] | IPC:A61K31/536; C07D207/44; A61K31/40; C07K16/44; A01K67/027; C12N5/00;C07D265/30; C07D241/04; A61K31/5375; A61K31/495; C07D319/12; A61K31/357;C07D413/06; A61K31/421; C07D257/06; A61K31/41; C07D233/96; A61K31/4166;C07D211/82; A61K31/44; C07D413/10; C07D407/12; A61K31/5355; A61P3/04; A61P3/10;A61P9/00; A61P11/00; A61P9/04; A61P25/18; A61P11/06; A61P29/00; A61P31/18 | Oldest priority date: 2005-05-18 | Publication date: 2009-07-09

Score: 17.040009 | Text size: 220156 | Find: similardocuments

availablesubstances in 10 mM stock solutions in DMSO on 57 MTPs, each having 384 wells (ChemDiv,San Diego, USA). ... The substances were reordered in higher quantitiesfrom ChemDiv (San Diego, USA) for further investigations. ...2 3 3 TABLE B: Inhibitors of the PKA-RIIα-GST-AKAP 185 interaction(substance library FMP20000 (ChemDiv)) ID_No. MW IC50/μMComp_ID ChemDiv Struktur Formula g/mol RIIa-18d 147411602-1355 [[image:EMI-C00293]] C11H17N3 191.

Modulation of the Cooperativity Between the Ion Channels TRPM5 and TRPA1

S. Paul Lee [US]; Tulu Buber [US]; Rok Cerne [US]; Robert W. Bryant[US];S. Paul Lee [US]; Tulu Buber [US]; Rok Cerne [US]; Robert W. Bryant[US]

Publicationdate: 2009-07-09 | Patent publication No.: US-20090175848-A1|Assignees: S. Paul Lee [US]; Tulu Buber [US]; Rok Cerne [US]; Robert W. Bryant [US] | IPC: A61K39/395;C12N5/06; C12N5/08; A61K31/7105; A61K31/7088; C12Q1/68; C12Q1/44 | Oldest priority date:2007-09-17 | Publication date: 2009-07-09

Score: 13.10661 | Text size: 100868 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigrna-Aldrich (St.Louis, Mo.

Inhibitors Of Neurotrypsin

PeterSonderegger [CH]; Stefan Hettwer[CH];Marc F. Bolliger[CH];Birgit Dreier[CH];Beat Kunz [CH]; Daniel Luscher[CH];Raymond Reif[CH];Susanne Sales[CH];PeterSonderegger [CH]; Stefan Hettwer[CH];Marc F. Bolliger[CH];Birgit Dreier[CH];Beat Kunz [CH]; Daniel Luscher[CH];Raymond Reif[CH];Susanne Sales[CH]

Publicationdate: 2009-07-02 | Patent publication No.: US-20090170950-A1|Assignees: Peter Sonderegger [CH]; Stefan Hettwer [CH]; Marc F. Bolliger [CH]; BirgitDreier [CH]; Beat Kunz [CH]; Daniel Luscher [CH]; Raymond Reif [CH]; SusanneSales [CH] | IPC: A61K31/18; A61P43/00; C07C303/00; C12Q1/00 | Oldest priority date: 2005-03-30 | Publication date: 2009-07-02

Score: 11.918776 | Text size: 159468 | Find: similardocuments

Compound No.7 (identification number 1672-3440 from ChemDiv, San Diego, Calif.

SCYLLO-INOSITOL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASESCHARACTERIZED BY ABNORMAL PROTEIN FOLDING OR AGGREGATION OR AMYLOID FORMATION,DEPOSITION, ACCUMULATION OR PERSISTENCE

Antonio Cruz[CA];Linda Kurdydyk[CA];Antonio Cruz[CA];Linda Kurdydyk[CA]

Score: 19.185947 | Text size: 203075 | Find: similardocuments

C 55.37% H7.75% O 36.88% IRL 2 [[image:EMI-C00185]] C 58.53% H 4.91% N 17.06% O19.49% ChemDiv 0 [[image:EMI-C00186]] C 67.82% H 4.38% O27.80% ChemDiv 0 [[image:EMI-C00187]] C 53.83% H 7.74% N17.94% O 20.49% ChemDiv 0 [[image:EMI-C00188]] C 48.00% H5.37% N 9.33% O 37.30% ChemDiv 0 [[image:EMI-C00189]] C 45.22%H 4.74% Cl 11.12% N 8.79% O 30.12% ChemDiv 0[[image:EMI-C00190]] C 49.75% H 5.57% Cl 12.24% N 4.83% O 27.61% ChemDiv 0[[image:EMI-C00191]] C 49.68% H 5.77% N 8.91% O 35.63% ChemDiv 0[[image:EMI-C00192]] C 49.75% H 5.57% Cl 12.24% N 4.83% O 27.61% ChemDiv 0[[image:EMI-C00193]] C 43.13% H 4.83% Br 23.91% N 4.19% O 23.94% ChemDiv 0[[image:EMI-C00194]] C 56.33% H 7.09% N 6.57% O 30.01% ChemDiv 0[[image:EMI-C00195]] C 66.93% H 11.70% N 6.50% O 14.

Methods and compositions for specific inhibition of protein splicing bysmall molecules

Henry Paulus[US];Henry Paulus[US]

Score: 19.994432 | Text size: 65600 | Find: similardocuments

Set 5,056 21(0.42%) Diversity Oriented Synthesis 16,030 23 (0.14%) ICCB Bioactives 489 4(0.82%) ChemDivCombilab/International 28,864 91 (0.32%) Bionet6,168 33 (0.54%) Maybridge 16,807 68 (0. ... — — 45 347 3.46 −4.59 N N NN −8.39 0.34 Bionet 5 <5 5 2.5 51 561 4.43 −5.53 Hi N N N−2.46 0.12 ChemDiv 2 <5 — — 53 472 3.10 −6.20Hi N Med Med −6.50 0.10 ChemDiv 1 1 <<5 ~20 — 54375 5.49 −5.95 N N N N −7.45 0.20ChemDiv 6 11 5 10 55384 4.54 −5.08 N N N N −14.00 0.21 ChemDiv 1 15 75 20 56 373 2.84 −4.23 N N N N −3.14 0.38 ChemDiv 9<35* 10* — — 57 354 4.19 −5.28 N N N N −8.25 0.28 Bionet <5 5— — 58 385 4.66 −6.

INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS

VERKMAN, Alan,S. [US];DE LA FUENTEGONZALEZ, Ricardo [ES]; VERKMAN, Alan,S. [US];DE LA FUENTEGONZALEZ, Ricardo [ES]

Score: 14.450268 | Text size: 207446 | Find: similardocuments

Compoundsfor primary screening were purchased from ChemDiv (San Diego,CA). ... Compounds for the secondary screening were purchased from ChemDiv andAsinex.

CATIONIC LIPIDS

MuthiahManoharan [US]; KallanthottahilG. Rajeev [US]; MuthusamyJayraman [US]; K. NarayanannairJayaprakash [US]; MuthiahManoharan [US];KallanthottahilG. Rajeev [US]; MuthusamyJayraman [US]; K. NarayanannairJayaprakash [US]

Score: 10.354719 | Text size: 284389 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, SanDiego, Calif.

BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS

Paul Gillespie[US];Robert AlanGoodnow, JR. [US]; Jefferson WrightTilley [US];Paul Gillespie[US];Robert AlanGoodnow, JR. [US]; Jefferson WrightTilley [US]

Publicationdate: 2009-06-18 | Patent publication No.: US-20090156635-A1|Assignees: Paul Gillespie [US]; Robert Alan Goodnow, JR. [US]; Jefferson Wright Tilley[US] |IPC: A61K31/4709; C07D401/10; A61P3/10 | Oldest priority date: 2004-12-03 | Publication date: 2009-06-18

Score: 17.377876 | Text size: 144849 | Find: similardocuments

Specs andBiospecs, Rijswijk, Netherlands 2-(3,5-Dimethyl-pyrazol-1-yl)phenol ChemDiv,Inc. San Diego, CA 4-(5-Methyl-furan-2-yl)-phenol ChemDiv,Inc. San Diego, CA 1-Phenyl-1H-5-(5′-chloro-2′hydroxy-4′-methylphenyl)pyrazoleAldrich Chemical Company, Inc., Milwaukee, WI2-(3,5-Dimethyl-1-phenyl-1Hpyrazol-4-yl)-phenol ChemDiv, Inc. SanDiego, CA Compounds of formula 4 that are not known in the literature may beprepared using

MATERIALS AND METHODS FOR INHIBITING MAMMALIAN S-NITROSOGLUTATHIONEREDUCTASE

SANGHANI, Paresh[US];SANGHANI, Paresh[US]

Score: 13.327991 | Text size: 91037 | Find: similardocuments

Thescreening for GSNOR inhibitors was performed using a library of 60,000compounds from ChemDiv Inc in the Chemical Genomics Corefacility at Indiana University.

A MAMMALIAN CELL-BASED SCREENING ASSAY TO IDENTIFY INHIBITORS OFALPHAVIRUSES

VIDALAIN,Pierre-Olivier [FR]; TANGY,Frédéric [FR]; JACOB, Yves [FR]; LUCAS-HOURANI,Marianne [FR]; MUNIER-LEHMANN,Hélène [FR]; LUPAN, Alexandre[FR];VIDALAIN,Pierre-Olivier [FR]; TANGY,Frédéric [FR]; JACOB, Yves [FR]; LUCAS-HOURANI,Marianne [FR]; MUNIER-LEHMANN,Hélène [FR]; LUPAN, Alexandre[FR]

Publicationdate: 2009-06-04 | Patent publication No.: WO-2009068998-A1|Assignees: INSTITUT PASTEUR [FR]; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR];INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR] | IPC: C12Q1/68 | Oldest priority date: 2007-11-30 | Publication date: 2009-06-04

Score: 14.293713 | Text size: 75578 | Find: similardocuments

performedupon five chemical compound libraries were tested: Prestwick Chemical (1120molecules),ChemDiv kinase inhibitors (9360 molecules), NECANnucleoside analogs library (4880 molecules), Institut

Non-desensitizing mutant of the transient receptor potential TRPM5 ionchannel

Robert W. Bryant[US];S. Paul Lee [US]; Rok Cerne [US]; M.N. Tulu Buber[US];Ivona Bakaj [US]; Kyle Palmer [US]; Robert W. Bryant[US];S. Paul Lee [US]; Rok Cerne [US]; M.N. Tulu Buber[US];Ivona Bakaj [US]; Kyle Palmer [US]

Publicationdate: 2009-05-28 | Patent publication No.: US-20090136975-A1|Assignees: Robert W. Bryant [US]; S. Paul Lee [US]; Rok Cerne [US]; M.N. Tulu Buber[US]; Ivona Bakaj [US]; Kyle Palmer [US] | IPC: C12Q1/56;C12N15/11; C12N15/00; C12N5/08; C07K14/00; C12P21/04; C12Q1/02 | Oldest priority date: 2007-10-01 | Publication date: 2009-05-28

Score: 13.327991 | Text size: 98261 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

USE OF STEM CELLS TO GENERATE INNER EAR CELLS

Stefan Heller[US];Albert Edge [US]; Stefan Heller[US];Albert Edge [US]

Score: 12.484504 | Text size: 126751 | Find: similardocuments

availablecompound libraries (suppliers include Chembridge Corp (San Diego, Calif.)and ChemDiv (San Diego, CA)).

Electrophysiological assays using oocytes that express human enac and theuse of phenamil to improve the effect of enac enhancers in assays usingmembrane potential reporting dyes

Score: 12.290053 | Text size: 168469 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis,Mo.

Identification of TRPML3 (MCOLN3) as a Salty Taste Receptor and Use inAssays for Identifying Taste (Salty) Modulators and/or Therapeutics that ModulateSodium Transport, Absorption or Excretion and/or Aldosterone and/or VasopressinProduction or Release

Bryan Moyer [US]; Albert Zlotnik[US];Peter Hevezi[US];Hortensia Soto[US];Dalia Kalabat[US];Min Lu [US]; Na Gao [US]; Evan Carl White[US];Guy Servant [US]; Paul Brust [US]; Mark Williams[US];Bryan Moyer [US]; Albert Zlotnik[US];Peter Hevezi[US];Hortensia Soto[US];Dalia Kalabat[US];Min Lu [US]; Na Gao [US]; Evan Carl White[US];Guy Servant [US]; Paul Brust [US]; Mark Williams[US]

Publicationdate: 2009-05-07 | Patent publication No.: US-20090117563-A1|Assignees: Bryan Moyer [US]; Albert Zlotnik [US]; Peter Hevezi [US]; Hortensia Soto[US]; Dalia Kalabat [US]; Min Lu [US]; Na Gao [US]; Evan Carl White [US]; GuyServant [US]; Paul Brust [US]; Mark Williams [US] | IPC: C12Q1/68;C12N5/00; C07K14/705; C12N5/06; G01N33/53; C12N1/21; C12N1/19; C12Q1/02 | Oldest priority date: 2007-06-08 | Publication date: 2009-05-07

Score: 8.202065 | Text size: 444233 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

Compositions and Methods for Treating Cancer

Peter S. Lu [US]; Michael P.Belmares [US]; Jingjing Wang[US];JohannesSchweizer [US]; Aida A. Fantaye[US];Peter S. Lu [US]; Michael P.Belmares [US]; Jingjing Wang[US];Johannes Schweizer[US];Aida A. Fantaye[US]

Publicationdate: 2009-05-07 | Patent publication No.: US-20090118301-A1|Assignees: Arbor Vita Corporation [US] | IPC: A61K31/497; A61K31/40; A61K31/34; C07D403/14; C07D403/04; A61K31/4164 | Oldest priority date: 2007-11-02 | Publication date: 2009-05-07

Score: 14.165414 | Text size: 62984 | Find: similardocuments

Accelryssoftware (Accelrys, San Diego, Calif.) was used to model and dock a moleculelibrary (ChemDiv, San Diego, Calif.; Blanca Pharmaceuticals, MountainView, Calif.

COMPOSITIONS AND METHODS FOR TREATING CANCER

LU, Peter, S.[US];BELMARES,Michael, P. [US]; WANG, Jingjing[US];SCHWEIZER,Johannes [US]; FANTAYE, Aida,A. [US];LU, Peter, S.[US];BELMARES,Michael, P. [US]; WANG, Jingjing[US];SCHWEIZER,Johannes [US]; FANTAYE, Aida,A. [US]

Score: 14.293713 | Text size: 64439 | Find: similardocuments

Accelryssoftware (Accelrys, San Diego, Calif.) was used to model and dock a moleculelibrary (ChemDiv, San Diego, Calif.; Blanca Pharmaceuticals, MountainView, Calif.

CHEMICAL INHIBITORS OF BFL-1 ANDRELATED METHODS

John C. Reed[US];Dayong Zhai [US]; Shinichi Kitada[US];Eduard Sergienko[US];John C. Reed[US];Dayong Zhai [US]; Shinichi Kitada[US];Eduard Sergienko[US]

Score: 19.664068 | Text size: 179498 | Find: similardocuments

Bfl-1FPABfl-1 TRFRET IC50 PubChem— Vendor Cat # R1 R2 R3 Mol Wt ClogP IC50 (uM) (uM)SID ChemDivC071-0649 [[image:EMI-C00078]] [[image:EMI-C00079]] H460.4 3.7 40.4 11.4 4252027 ChemDiv C164-0003 H[[image:EMI-C00080]] H 302. ... ASN05990586 [[image:EMI-C00098]][[image:EMI-C00099]] H 491.5 4.1 11.3 5.3 852701 ChemDiv C164-0006H [[image:EMI-C00100]] H 292.2 2.8 7.2 6.0 4243100 ChemDiv C164-0014H [[image:EMI-C00101]] H 362.3 3.4 40.7/5.92/27.2/28.8/22.9/Avg25.15.29/3.73/10.1/Avg 6.38 ChemDivC164-0017 H [[image:EMI-C00102]][[image:EMI-C00103]] 294.3 3.2 nodisplacement nodisplacement 4252269 ChemBridge7979496 [[image:EMI-C00104]] [[image:EMI-C00105]] H 440.4 3.4 14.6 9.24254739 ChemDivC071-0415 [[image:EMI-C00106]] [[image:EMI-C00107]]H 484.

FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF

KazumasaHamamura [JP]; Tsuneo Oda [JP]; Tomohiro Kaku[JP];Tomohiro Suzaki[JP];KazumasaHamamura [JP]; Tsuneo Oda [JP]; Tomohiro Kaku[JP];Tomohiro Suzaki[JP]

Publicationdate: 2009-03-05 | Patent publication No.: US-20090062258-A1|Assignees: Takeda Pharmaceutical Company Limited [JP] |IPC: A61K31/55; C07D239/70; A61K31/519; C07D495/04 | Oldest priority date: 2005-02-03 | Publication date: 2009-03-05

Score: 9.370946 | Text size: 345550 | Find: similardocuments

27(5), p.1341-4 (1990), Journal of the Chinese Chemical Society, vol. 49(3), p. 407-414(2002), ChemDiv, Inc.Product Library catalog, and ScientificExchange Product List.

Small Molecule Inhibitors of PDZ Interactions

Michael P.Belmares [US]; Kenneth A.Mendoza [US]; Peter S. Lu [US]; David Garman[US];MichaelTymianski [CA]; Michael P.Belmares [US];Kenneth A.Mendoza [US]; Peter S. Lu [US]; David Garman[US];MichaelTymianski [CA]

Publicationdate: 2009-03-05 | Patent publication No.: US-20090062213-A1|Assignees: Arbor Vita Corporation [US]; NoNO Inc. [CA] | IPC:A61K38/06; A61K38/02; A61P25/28; A61P25/00 | Oldest priority date: 2005-12-30 | Publication date: 2009-03-05

Score: 15.5924425 | Text size: 151821 | Find: similardocuments

PYRIMIDINE AND PYRIDINE DERIVATIVES AS POSH AND POSH-AP INHIBITORS

NAKACHE,Philippe [IL]; LIVNAH, Nurit[IL];NAKACHE,Philippe [IL]; LIVNAH, Nurit[IL]

Publicationdate: 2009-02-26 | Patent publication No.: WO-2009024980-A2|Assignees: PROTEOLOGICS LTD [IL] | IPC: A61K31/505; A61P31/18; A61K31/44; A61P25/16; A61P25/00; A61P25/28;A61P31/12; A61P25/24; A61P31/14; C07D213/75 | Oldest priority date: 2007-08-22 | Publication date: 2009-02-26

Score: 12.484504 | Text size: 126663 | Find: similardocuments

Moscow,Russia; ChemDiv, San Diego USA) was then cherry-picked, collectedand then screened for their effect on

PROTEASOME INHIBITORS AND THEIR USE IN TREATING PATHOGEN INFECTION ANDCANCER

NATHAN, Carl[US];LIN, Gang [US]; NATHAN, Carl[US];LIN, Gang [US]

Score: 16.930674 | Text size: 84794 | Find: similardocuments

GLl, GL2,GL3, GL4 were purchased from TimTec LLC (DE, USA) and GL5, GL6, GL7 from ChemDiv,Inc. (CA, USA). Bortezomib was purchased from LC Laboratories (MA,USA). ... Example 2 - High Throughput Screen [0054] The screening was conductedwith compounds from ChemDiv, Chembridge, Spectrum, Preswick, andCerep.

HYDRAZIDE-CONTAINING CFTR INHIBITOR COMPOUNDS AND USES THEREOF

Alan Verkman[US];Nitin DattatrayaSonawane [US]; ChatchaiMuanprasat [TH]; Alan Verkman[US];Nitin DattatrayaSonawane [US]; ChatchaiMuanprasat [TH]

Publicationdate: 2009-02-19 | Patent publication No.: US-20090048207-A1|Assignees: The Regents of the University of California [US] |IPC: A61K31/7016; A61K31/16; C12N5/02; A61K31/195; A61K31/47 | Oldest priority date: 2004-03-30 | Publication date: 2009-02-19

Score: 11.569273 | Text size: 174196 | Find: similardocuments

(most350-550 daltons) were selected for screening from commercial sources (ChemBridgeand ChemDiv, both of San Diego, Calif.

GALACTOKINASE INHIBITORS

LAI, Kent [US]; KLAAS, JanWierenga [US]; TANG, Manshu[US];LAI, Kent [US]; KLAAS, JanWierenga [US]; TANG, Manshu[US]

Score: 21.2422 | Text size: 165071 | Find: similardocuments

(Hexachlorophene);SMP2_000049 Sigma E9259 (Erythrosin B); ChemDiv3_007133 ChemDiv 7218-1483;TimTecl_001324 TimTec ST014236; ChemDiv3_007089 ChemDiv 7218-1459;Maybridge4_001932 JFD03061; TimTec l_O00233 TimTec ST000572;ChemDiv3_014119 ChemDiv 7218-1576; ChemDiv3_001694 ChemDiv3241-0272;SPBio_000126 Spectrum2_000113 (Bithionol); SPBio_001697 Spectrum2_001629(Rhodomyrtoxin); ChemDiv3_002334 ChemDiv 3696- 0201;ChemDiv3_OOO9O3 ChemDiv 1887-0088; TimTec l_001108 TimTecST014268; Maybridge4_001288 HTSOl 859; SMP2_000320 Sigma S 1014(Streptonigrin); TimTec l_001055 TimTec STO 12305; ChemDiv3_001508 ChemDiv 3229-1543;ChemDiv3_007160 ChemDiv 8012-2663; ChemDiv3_001677 ChemDiv 3062-0036;TimTec l_003525 TimTec ST048025; BiomolKI2_000062 BiomolEI-307;ChemDiv3_001693 ChemDiv

GALACTOKINASE INHIBITORS

LAI, Kent [US]; KLAAS, JanWierenga [US]; TANG, Manshu[US];LAI, Kent [US]; KLAAS, JanWierenga [US]; TANG, Manshu[US]

Score: 21.2422 | Text size: 165384 | Find: similardocuments

ANTI-BACTERIAL DRUG TARGETING OF GENOME MAINTENANCE INTERFACES

KECK, James, L.[US];BERNSTEIN,Douglas, A. [US]; KECK, James, L.[US];BERNSTEIN,Douglas, A. [US]

Score: 11.918776 | Text size: 570976 | Find: similardocuments

Diego, CA),from the Maybridge HitFinder library (Thermo Fisher Scientific, Waltham, MA),from the ChemDivlibrary (Chemical Diversity Labs, San Diego, CA),or from the Known Bioactive Library - KBA01.

COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS

WU, JayJie-qiang [US]; WANG, Ling [US]; WU, JayJie-qiang [US]; WANG, Ling [US]

Score: 11.239684 | Text size: 184002 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (SanDiego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, TheNetherlands), Timtec (Newark, DE) or can be synthesized.

Tetrahydrocarbazoles as Active Agents for Inhibiting VEGF Production byTranslational Control

William Lennox[US];Hongyan Qi [US]; Duck-Hyung Lee[KR];Soongyu Choi[US];Young-Choon Moon[US];William Lennox[US];Hongyan Qi [US];Duck-Hyung Lee[KR];Soongyu Choi[US];Young-Choon Moon[US]

Publicationdate: 2009-02-12 | Patent publication No.: US-20090042866-A1|Assignees: William Lennox [US]; Hongyan Qi [US]; Duck-Hyung Lee [KR]; Soongyu Choi[US]; Young-Choon Moon [US] | IPC: A61K31/5513; C07D209/82; A61K31/403; A61K31/497; C07D403/02; C07D413/02;A61K31/5377; A61K31/422; C07D401/02; A61K31/4439; A61K31/423; C07D498/00;A61K31/4245; A61K31/41; C07D285/06; C07D307/77; A61K31/343; A61K31/4155;A61P9/10; A61P3/04; A61P29/00; A61P17/06; A61P19/02; A61P27/02; A61P35/00;A61P7/00; A61K31/4196; A61K31/4192; A61K31/541; C07D417/02; C07D243/10;A61K31/4178; C07D487/00; C07D235/02; C07D498/02; A61K31/424; A61K31/4162;A61K31/506; C07D241/36; A61K31/498 | Oldestpriority date: 2004-11-23 | Publication date: 2009-02-12

Score: 19.295942 | Text size: 178765 | Find: similardocuments

ChemBridge5133291 [[image:EMI-C00301]] ChemBridge 5309760 [[image:EMI-C00302]] ChemDiv 8010-1969[[image:EMI-C00303]] ChemBridge 5259158 [[image:EMI-C00304]] Tripos 2000-13782[[image:EMI-C00305]] Chem Div 3606-0172 [[image:EMI-C00306]] ChemDiv 3474-0005[[image:EMI-C00307]] ChemDiv 0075-0033[[image:EMI-C00308]] ChemDiv 3606-0516 [[image:EMI-C00309]]Tripos 2000-12661 [[image:EMI-C00310]] Tripos ... ChemBridge 7111705[[image:EMI-C00323]] ChemBridge 5277652 [[image:EMI-C00324]] ChemDiv3474-0005[[image:EMI-C00325]] ChemDiv 3606-0161[[image:EMI-C00326]] ChemDiv 8005-8953 REFERENCES 1. CarmelietP. Angiogenesis in health and disease. Nat Med.

GENOMIC MUTATION INHIBITORS THAT INHIBIT Y FAMILY DNA POLYMERASES

ROMESBERG,Floyd, E. [US]; BACHOVCHIN,Daniel, A. [US]; ROMESBERG,Floyd, E. [US]; BACHOVCHIN,Daniel, A. [US]

Score: 10.928354 | Text size: 195699 | Find: similardocuments

(San Diego,CA) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, CA) providing a variety ofcompound diversity libraries including CombiLab and the

BENZOIND0L-2-ONE DERIVATIVES FOR USE IN THERAPY

WESTMAN, Jacob[SE];KULL, Björn[SE];STENBERG, Patric[SE];WESTMAN, Jacob[SE];KULL, Björn[SE];STENBERG, Patric[SE]

Publicationdate: 2009-02-05 | Patent publication No.: WO-2009016081-A2|Assignees: NOVASAID AB [SE] | IPC: C07D209/90; C07D405/12; A61K31/404; A61P9/00; A61P35/00; A61P37/00 | Oldest priority date: 2007-08-02 | Publication date: 2009-02-05

Score: 15.261294 | Text size: 38756 | Find: similardocuments

compounds ofthe present invention are commercially available from several sources suchas ChemDiv, ChemBridge etc.

LIPID CONTAINING FORMULATIONS

Publicationdate: 2009-01-22 | Patent publication No.: US-20090023673-A1|Assignees: Muthiah Manoharan [US]; Kallanthottathil G. Rajeev [US]; Akin Akinc [US];Narayanannair K. Jayaprakash [US]; Muthusamy Jayraman [US]; Martin Maier [US] | IPC: A61K47/14;A61K31/7088 |Oldest priority date: 2006-10-03 | Publicationdate: 2009-01-22

Score: 10.354719 | Text size: 273989 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, SanDiego, Calif.

IDENTIFICATION OF TRPML3 (MCOLN3) AS A SALTY TASTE RECEPTOR AND USE INASSAYS FOR IDENTIFYING TASTE (SALTY) MODULATORS AND/OR THERAPEUTICS THATMODULATE SODIUM TRANSPORT, ABSORPTION OR EXCRETION AND/OR ALDOSTERONE AND/ORVASOPRESSIN PRODUCTION OR RELEASE

MOYER, Bryan[US];ZLOTNIK, Albert[US];HEVEZI, Peter[US];SOTO, Hortensia[US];LU, Min [US]; GAO, Na [US]; SERVANT, Guy[US];BRUST, Paul [US]; WILLIAMS, Mark[US];KALABAT, Dalia[US];WHITE, Evan,Carl [US];SAGANICH,Michael [US]; LAITA, Bianca[US];DAHAN, David[US];MOYER, Bryan[US];ZLOTNIK, Albert[US];HEVEZI, Peter[US];SOTO, Hortensia[US];LU, Min [US]; GAO, Na [US]; SERVANT, Guy[US];BRUST, Paul [US]; WILLIAMS, Mark[US];KALABAT, Dalia[US];WHITE, Evan,Carl [US];SAGANICH,Michael [US]; LAITA, Bianca[US];DAHAN, David[US]

Score: 7.874651 | Text size: 406479 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES

RICCIARDI,Robert, P. [US]; YOUNG, Janice,Elaine P. [US]; CIUSTEA, Mihai[US];RICCIARDI,Robert, P. [US]; YOUNG, Janice,Elaine P. [US]; CIUSTEA, Mihai[US]

Score: 12.290053 | Text size: 150516 | Find: similardocuments

A total of45,832 chemical compounds from the following libraries: ChemDiv 3(16,544 compounds), MixCommercial 5 (268 compounds), Maybridge 4 (4,576compounds), ActiMol

METHODS OF RESTORING COGNITIVE ABILITY USING NON-PEPTIDIC COMPOUNDS

Grant A. KRAFFT[US];Todd Pray [US]; William F. Goure[US];Grant A. KRAFFT[US];Todd Pray [US]; William F. Goure[US]

Score: 20.652145 | Text size: 84830 | Find: similardocuments

3.2 ChemDiv 12.[[image:EMI-C00013]] (5-hydroxy-3-propyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)(2-hydroxyphenyl)methanone8.5 ChemDiv 13. [[image:EMI-C00014]]N-(4-bromophenyl)-2-(3-ethyl-5-hydroxy-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoacetamide17.0 ChemDiv 14. [[image:EMI-C00015]]2-(5-hydroxy-3-propyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-oxo-N-phenethylacetamide34.4 ChemDiv15. [[image:EMI-C00016]]N-(4-bromophenyl)-2-(5-hydroxy-3-propyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoacetamide7.8 ChemDiv 16. [[image:EMI-C00017]]2-(3-butyl-5-hydroxy-5-trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-oxo-N-phenethylacetamide38.8 ChemDiv 17.

METHODS OF MODIFYING AMYLOID beta OLIGOMERS USING NON-PEPTIDIC COMPOUNDS

Grant A. Krafft[US];Todd Pray [US]; William F. Goure[US];Grant A. Krafft[US];Todd Pray [US]; William F. Goure[US]

Score: 14.039395 | Text size: 80203 | Find: similardocuments

3.2 ChemDiv 6.[[image:EMI-C00007]](E)-2-hydroxy-N′-((1-hydroxynaphthalen-2-yl)methylene)benzo-hydrazide 3.8

Compounds and methods for modulating functions of nonclassical cadherins

Orest W Blaschuk[CA];Stephanie DMichaud [CA]; Orest W Blaschuk[CA];Stephanie DMichaud [CA]

Score: 10.089907 | Text size: 333345 | Find: similardocuments

from adatabase (e.g., Cambridge Crystallographic Database, Maybridge StructuralDatabase, and ChemDivDatabase).

Flavors, flavor modifiers, tastants, taste enhancers, umami or sweettastants, and/or enhancers and use thereof

CatherineTachdjian [US]; Xiaodong Li [US]; Ming Qi [CN]; Marketa Rinnova[US];Guy Servant [US]; Mark Zoller [US]; CatherineTachdjian [US];Xiaodong Li [US]; Ming Qi [CN]; Marketa Rinnova[US];Guy Servant [US]; Mark Zoller [US]

Score: 8.94598 | Text size: 339533 | Find: similardocuments

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia Pa., ChemDiv of San Diego Calif., Chembridge ofSan Diego Calif.

METHODS AND COMPOSITIONS FORTREATING SKIN CONDITIONS

POJASEK, Kevin[US];STEINBERG, David[US];ZOHAR, Daphne[US];POJASEK, Kevin[US];STEINBERG, David[US];ZOHAR, Daphne[US]

Score: 10.089907 | Text size: 204734 | Find: similardocuments

Compounds and methods for modulating functions of classical cadherins

Orest W.Blaschuk [CA]; Stephanie D.Michaud [CA]; Orest W.Blaschuk [CA]; Stephanie D.Michaud [CA]

Score: 13.939713 | Text size: 267579 | Find: similardocuments

from adatabase (e.g., Cambridge Crystallographic Database, Maybridge StructuralDatabase, and ChemDivDatabase). ... The other database used in thestructure-based screen, ChemDiv (CDC) database, includes298,440 compounds, 175,316 compounds from the international diversity

NOVEL MOLECULES FOR REGULATING CELL DEATH

Jodi Nunnari[US];AnnCassidy-Stone [US]; Mark Kurth [US]; Jodi Nunnari[US];AnnCassidy-Stone [US]; Mark Kurth [US]

Score: 13.10661 | Text size: 112757 | Find: similardocuments

1,900 0 0Peakdale 2,800 0 0 Bionet 4,800 6 2 Cerep 4,800 3 2 Maybridge 8,800 22 10 ChemDiv 29,00054 23 KnownBioactives 1,040 1 0 Total 52,100 86 (.0017) 37 (.0007) Smallmolecules were

G protein coupled receptor signaling modulation

AnnetteGilchrist [US]; Heidi M. Hamm[US];AnnetteGilchrist [US]; Heidi M. Hamm[US]

Publicationdate: 2008-11-13 | Patent publication No.: US-20080280308-A1|Assignees: Caden Biosciences [US] | IPC: G01N33/53; C07K2/00; C07K7/06; C12N15/63; C12N5/06; C40B30/04 | Oldest priority date: 2001-03-14 | Publication date: 2008-11-13

Score: 17.226006 | Text size: 241987 | Find: similardocuments

smallmolecules, such as β-turnmimetic libraries and the like, may be purchased from for example ChemDiv,Pharmacopia or Combichem or synthesized and are described in Tietze and Lieb,Curr. Opin. Chem. ... For example, ChemDiv uses more than 800individual chemical cores, a unique Building Block Library, and proprietary ...In addition, ChemDiv's compounds are designed to ensure their similarityto drugs adjusted according to proprietary ... were employed to screen a smallmolecule library (a 10,000 compound library representative of ChemDiv'sDiverse Collection of drug-like molecules) for compounds that bind activatedrhodopsin and

METHODS OF TREATING FUNGAL INFECTIONS

LEWIS, Kim [US]; LAFLEUR,Michael, David [US]; LEWIS, Kim [US]; LAFLEUR,Michael, David [US]

Publicationdate: 2008-11-13 | Patent publication No.: WO-2008137128-A2|Assignees: NORTHEASTERN UNIVERSITY [US] | IPC:A61K31/05;A61K31/10; A61K31/166; A61K31/4412; A61K31/472; A61K31/473; A61K31/655;A61P31/10 | Oldestpriority date: 2007-05-03 |Publicationdate: 2008-11-13

Score: 17.251234 | Text size: 120410 | Find: similardocuments

Use of stem cells to generate inner ear cells

Huawei Li [CN]; Albert Edge [US]; Stefan Heller[US];Huawei Li [CN]; Albert Edge [US]; Stefan Heller[US]

Publicationdate: 2008-10-30 | Patent publication No.: US-20080267929-A1|Assignees: Huawei Li [CN]; Albert Edge [US]; Stefan Heller [US] | IPC: A61K35/30;C12N5/02; C12Q1/68; A61P27/16; G01N33/53 | Oldest priority date: 2003-11-13 | Publication date: 2008-10-30

Score: 12.290053 | Text size: 134646 | Find: similardocuments

availablecompound libraries (suppliers include ChemBridge Corp (San Diego, Calif.)and ChemDiv (San Diego, Calif.)).

Aryl Urea Derivatives for Treating Obesity

Jason Bloxham[GB];Matthew ColinThor Fyfe [GB]; James Horswill[GB];Revathy PerpetuaJeevaratnam [GB]; John Keily [GB]; Martin JamesProcter [GB]; Karen LesleySchofield [GB]; Salam Shaaban[US];Andrew SimonSwain [GB];PhillppeWong-Kai-In [GB]; Jason Bloxham[GB];Matthew ColinThor Fyfe [GB]; James Horswill[GB];Revathy PerpetuaJeevaratnam [GB]; John Keily [GB]; Martin JamesProcter [GB]; Karen LesleySchofield [GB]; Salam Shaaban[US];Andrew SimonSwain [GB];PhillppeWong-Kai-In [GB]

Publicationdate: 2008-10-23 | Patent publication No.: US-20080261952-A1|Assignees: Jason Bloxham [GB]; Matthew Colin Thor Fyfe [GB]; James Horswill [GB];Revathy Perpetua Jeevaratnam [GB]; John Keily [GB]; Martin James Procter [GB];Karen Lesley Schofield [GB]; Salam Shaaban [US]; Andrew Simon Swain [GB];Phillppe Wong-Kai-In [GB] | IPC: A61K31/167; A61P1/00 | Oldestpriority date: 2004-08-16 |Publicationdate: 2008-10-23

Score: 12.290053 | Text size: 141571 | Find: similardocuments

3.73 291.2[M+ H]+ 139 [[image:EMI-C00152]] 4-[3-(3-Chlorophenyl)ureido]benzoic acidethylester ChemDiv4.33 319.

COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER

TOMKINSON, AlanE. [US];CHEN, Xi [US]; DZIEGIELEWSKA,Barbara [US]; MACKERELL,Alexander D. [US]; ZHONG, Shijun[US];WILSON, GeraldM. [US];TOMKINSON, AlanE. [US];CHEN, Xi [US]; DZIEGIELEWSKA,Barbara [US]; MACKERELL,Alexander D. [US]; ZHONG, Shijun[US];WILSON, GeraldM. [US]

Score: 13.327991 | Text size: 110689 | Find: similardocuments

Chemicals.[40] Compounds identified by CADD screening were purchased fromChemBridge, ChemDiv, MayBridge, MDD, Nanosyn, Specs, Timtec, andTripos.

Substituted Sulfonamide Compounds

StefanOBERBOERSCH [DE]; Melanie Reich[DE];Stefan Schunk[DE];Sabine Hees [DE]; Ruth Jostock[DE];Michael Engels[DE];Achim Kless [DE];Thomas Christoph[DE];Klaus Schiene[DE];Tieno Germann[DE];EdwardBijsterveld [NL]; StefanOBERBOERSCH [DE]; Melanie Reich[DE];Stefan Schunk[DE];Sabine Hees [DE]; Ruth Jostock[DE];Michael Engels[DE];Achim Kless [DE]; Thomas Christoph[DE];Klaus Schiene[DE];Tieno Germann[DE];EdwardBijsterveld [NL]

Publicationdate: 2008-10-09 | Patent publication No.: US-20080249128-A1|Assignees: GRUENENTHAL GmbH [DE] | IPC: A61K31/4545; C07D409/14; C07D401/14; C07D401/04; A61P25/00; A61P11/00;A61P29/00; A61P3/10; A61K31/4725; C07D409/04; C07D401/02 | Oldest priority date: 2006-10-16 | Publication date: 2008-10-09

Score: 11.569273 | Text size: 239982 | Find: similardocuments

Fluka,Lancaster, Maybridge, Merck, Sigma, TCi, Fulcrum Scientific, Array Biopharma,Asinex, ChemDiv etc.). Silica gel 60 (0.040-0.

INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK

PELLECCHIA,Maurizio [US]; PELLECCHIA,Maurizio [US]

Score: 11.569273 | Text size: 179282 | Find: similardocuments

from severalcommercially available repositories (Maybridge, UK; Chembridge, USA; Asinex, Russia; ChemDiv,USA; SIGMA rare, USA; ASDI, USA) were screened in silico.

HOX-GENE EXPRESSION AS A BIOMARKER FOR IGF-1R THERAPEUTICS

BERTRAND, Fred,Edmond, III [US]; WHELAN, Jarrett,Thomas [US];BERTRAND, Fred,Edmond, III [US]; WHELAN, Jarrett,Thomas [US]

Publicationdate: 2008-09-25 | Patent publication No.: WO-2008115470-A2|Assignees: EAST CAROLINA UNIVERSITY [US] | IPC:A61K39/395;G01N33/53; C12Q1/68; A61K31/70; C07H21/04; C07K16/22; C07K16/28 | Oldest priority date: 2007-03-16 | Publication date:2008-09-25

Score: 12.290053 | Text size: 164553 | Find: similardocuments

Forexample, ChemDiv (San Diego, CA) provides high throughput hithunting services involving assay development and

NOVEL AGENTS OF CALCIUM ION CHANNEL MODULATORS

WU, JayJie-Qiang [US]; GUO, Jian-Xin[US];NGUYEN, Luat T.[US];WU, JayJie-Qiang [US]; GUO, Jian-Xin[US];NGUYEN, Luat T.[US]

Score: 10.633806 | Text size: 256718 | Find: similardocuments

Mo.),Maybridge (Cornwall, England), Asinex (Winston-Salem, NC), ChemBridge (SanDiego, CA ), ChemDiv (San Diego, CA), SPECS (Delft, TheNetherlands), Timtec (Newark, DE) or the compounds can be

Small Molecule Inhibitors of PDZ Interactions

MICHAEL P.BELMARES [US]; Peter S. Lu [US]; Kenneth A.Mendoza [US]; MICHAEL P.BELMARES [US]; Peter S. Lu [US]; Kenneth A.Mendoza [US]

Publicationdate: 2008-09-18 | Patent publication No.: US-20080227684-A1|Assignees: MICHAEL P. BELMARES [US]; Peter S. Lu [US]; Kenneth A. Mendoza [US] | IPC: A61K31/404;A61K31/195; A61P25/00; A61K31/519; C07K2/00; C07D209/10; C07C311/46;C07D491/147; A61K38/00 | Oldestpriority date: 2005-12-30 | Publication date: 2008-09-18

Score: 15.748037 | Text size: 131774 | Find: similardocuments

withAccelrys software (Accelrys, San Diego, Calif.) to model and dock a 650,000molecule library (ChemDiv, San Diego, Calif.; Blanca Pharmaceuticals,Mountain View, Calif. ... multiple conformations for each molecule; and, 4)From approximately 650,000 test compounds (ChemDiv, San Diego, Calif.;Blanca Pharmaceutical, Mountain View, Calif.

Methods and Systems for the Identification of Rna Regulatory Sequencesand Compounds that Modulate their Function

Matthew C.Pellegrini [US]; Christopher R.Trotta [US];Shah I. Huq [US]; Matthew C.Pellegrini [US]; Christopher R.Trotta [US];Shah I. Huq [US]

Publicationdate: 2008-09-18 | Patent publication No.: US-20080227085-A1|Assignees: Matthew C. Pellegrini [US]; Christopher R. Trotta [US]; Shah I. Huq [US] | IPC: C12Q1/68;G01N33/00 | Oldestpriority date: 2003-01-17 | Publication date: 2008-09-18

Score: 13.793969 | Text size: 109123 | Find: similardocuments

Methods and compositions for soluble CPG15

Elly Nedivi [US]; Ulrich Putz [US]; Elly Nedivi [US]; Ulrich Putz [US]

Score: 12.290053 | Text size: 141550 | Find: similardocuments

arecommercially available from Nanoscale Combinatorial Synthesis Inc., MountainView, Calif., ChemDiv Inc., San Diego, Calif., Pharmacopeia DrugDiscovery, Princeton, N.J., and ArQule Inc., Medford, Mass.

NEW TUMOR MOUSE MODELS USING LENTIVIRAL VECTORS

MARUMOTO,Tomotoshi [US]; VERMA, Inder[US];SODA, Yasushi[US];XIA, Yifeng [US]; MARUMOTO,Tomotoshi [US]; VERMA, Inder[US];SODA, Yasushi[US];XIA, Yifeng [US]

Score: 11.569273 | Text size: 210845 | Find: similardocuments

(San Diego,CA) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, CA) providing a variety ofcompound diversity libraries including CombiLab and the

SIRT INHIBITORS THAT BIND TO NAD

Manuel A. Navia[US];Jeffrey O.Saunders [US]; Manuel A. Navia[US];Jeffrey O.Saunders [US]

Score: 11.569273 | Text size: 177907 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, San Diego, Calif.

Hydrazide-containing CFTR inhibitor compounds and uses thereof

Alan Verkman[US];Nitin DattatrayaSonawane [US]; ChatchaiMuanprasat [TH]; Alan Verkman[US];Nitin DattatrayaSonawane [US]; ChatchaiMuanprasat [TH]

Score: 11.239684 | Text size: 185964 | Find: similar documents

(most350-550 daltons) were selected for screening from commercial sources(ChemBridge and ChemDiv, both of San Diego, Calif.

PARAMYXOVIRUS FAMILY INHIBITORS AND METHODS OF USE THEREOF

PLEMPER,Richard, K. [US]; SNYDER, James,P. [US];SUN, Aiming [US]; PLEMPER,Richard, K. [US]; SNYDER, James,P. [US];SUN, Aiming [US]

Score: 12.892465 | Text size: 117039 | Find: similardocuments

The compoundlibrary used is a diversity set from ChemDiv (San Diego, CA).Example 3 Chemical synthesis of compound 16677.

GHRELIN RECEPTOR MODULATORS

LINNANEN, Tero[DK];RIST,Øystein [DK]; GRIMSTRUP, Marie[DK];FRIMURER, Thomas[DK];HOEGBERG, Thomas[SE];NIELSEN,Flemming, Elmelund [DK]; GERLACH,Lars-Ole [DK]; LINNANEN, Tero[DK];RIST,Øystein [DK]; GRIMSTRUP, Marie[DK];FRIMURER, Thomas[DK];HOEGBERG, Thomas[SE];NIELSEN,Flemming, Elmelund [DK]; GERLACH,Lars-Ole [DK]

Publicationdate: 2008-08-07 | Patent publication No.: WO-2008092681-A1|Assignees: PROSIDION LIMITED [GB] | IPC: C07D307/00; C07D491/08; A61K31/075; A61K31/34; A61K31/407; C07D209/56;C07D307/93; C07D491/18; C07D491/153; A61P3/04; A61P3/06; A61P3/10; A61P19/02;A61P43/00 | Oldestpriority date: 2007-02-02 | Publication date: 2008-08-07

Score: 17.251234 | Text size: 134779 | Find: similardocuments

Suchcollections can be obtained from ChemDiv INCTM, 6605 Nancy RidgeDrive, San Diego CA 92121- 2253, USA, or from Aurora Fine Chemicals Ltd ...Such collections can currently be obtained from ChemDiv INCTM,6605 Nancy Ridge Drive, San Diego CA 92121- 2253, USA, or from Aurora FineChemicals Ltd ... [[image:imgf000090_0001]] [[image:imgf000091_0002]] Thecommercial Examples were obtained from theChemDiv INCTM, 6605 NancyRidge Drive, San Diego CA 92121- 2253, USA.

Pharmaceutical compositionscomprising thieno[2,3-c]pyridine derivatives and use thereof

Paul Gregor [IL]; Nicholas Harris[IL];Juraj Koppel[IL];Regina Zhuk [IL]; Paul Gregor [IL]; Nicholas Harris[IL];Juraj Koppel[IL];Regina Zhuk [IL]

Publicationdate: 2008-04-29 | Patent publication No.: US-07365080-B2|Assignees: Rimonyx Pharmaceuticals Ltd. [IL] | IPC: A01N43/42;A61K31/44; C07D471/02; C07D491/02; C07D498/02 | Oldest priority date: 2003-02-05 | Publication date: 2008-04-29

Score: 12.290053 | Text size: 142351 | Find: similardocuments

Compoundswere synthesized or purchased from ChemDiv Labs (San Diego,Calif.

Sequences encoding hepatitis C virus glycoproteins

Julie Dumonceaux[FR];Emmanuel G.Cormier [US]; Jason P. Gardner[US];Tatjana Dragic[US];Julie Dumonceaux[FR];Emmanuel G.Cormier [US]; Jason P. Gardner[US];Tatjana Dragic[US]

Publicationdate: 2008-04-22 | Patent publication No.: US-07361503-B2|Assignees: Albert Einstein College of Medicine of Yeshiva University [US]; ProgenicsPharmaceuticals, Inc. [US] | IPC: C12N15/63 | Oldestpriority date: 2003-11-12 | Publication date: 2008-04-22

Score: 15.290299 | Text size: 201036 | Find: similardocuments

Forexample, ChemDiv (San Diego, Calif. ... ChemDiv hasa large number of small molecules that are usable as building blocks foridentifying and

UNDERCARBOXYLATED/UNCARBOXYLATED OSTEOCALCIN INCREASES BETA-CELLPROLIFERATION, INSULIN SECRETION, INSULIN SENSITIVITY, GLUCOSE TOLERANCE ANDDECREASES FAT MASS

KARSENTY, Gerard[US];DUCY, Patricia,F. [US];KARSENTY, Gerard[US];DUCY, Patricia,F. [US]

Score: 8.557886 | Text size: 416207 | Find: similardocuments

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN INHIBITORSAND USES THEREOF

Alan Verkman[US];Tonghui Ma [US]; Alan Verkman[US];Tonghui Ma [US]

Publicationdate: 2008-03-13 | Patent publication No.: US-20080064666-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A61K31/655;A61K31/426; A61P43/00; C12N5/08 | Oldestpriority date: 2002-09-30 | Publication date: 2008-03-13

Score: 12.290053 | Text size: 136147 | Find: similardocuments

Structure-activityanalysis was done on analogs purchased from ChemBridge and ChemDiv (SanDiego, Calif.

Method for evolving molecules and computer program for implementing thesame

De Winter, HansLouis Jos [BE]; Langenaeker,Wilfried Gert Roger [BE]

Score: 14.557414 | Text size: 101382 | Find: similardocuments

2,224 549Asinex 372,703 127,963 Aurora Feinchemie 1,019,555 305,231 ChemBridge 482,993200,666ChemDiv 605,230 207,539 Cerep 29,231 10,179 CMC 8,757 2,657ChemStar 60,260 15,128 Chem T&I 323,127

External link

Screening Assay for Inhibitors of TRPA1 Activation by a Lower AlkylPhenol

Paul LEE [US]; Qifeng Yang [US]; W. Bryant [US]; Tulu Buber [US]; Paul LEE [US]; Qifeng Yang [US]; W. Bryant [US]; Tulu Buber [US]

Score: 13.10661 | Text size: 99127 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St. Louis,Mo.

COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLSOVER-EXPRESSING BCL-2 FAMILY MEMBER PROTEINS

WU, JayJie-Qiang [US]; HOCKENBERY,David M. [US]; WANG, Ling [US]; GUO, Jianxin[US];WU, JayJie-Qiang [US]; HOCKENBERY,David M. [US];WANG, Ling [US]; GUO, Jianxin[US]

Score: 20.780664 | Text size: 104319 | Find: similardocuments

acid(2-oxo-l-phenethyl-l,2-dihydro- indol-3-ylidene-hydrazinocarbonylmethyl)-amide(ChemDiv., Inc., 1805-1390) 5:5-Naphthalen-2-yl-2H-pyrazole-3-carboxylic acid[3-(2-nitro-phenyl)-allylidene]- hydrazide (ChemDiv., Inc., 3254-3290)6: 1 -[5-Hydroxy-3-(3-methoxy-pheny.l)-5 -txifluoromethyl-4,5 -dihydro-pyrazol-1 -yl]- 3-phenyl-propan-l-one (ChemDiv., Inc., 3852-0615) 7:3-[2-(2-Methoxy-phenyl)-ethylamino]-l-(4-phenylazo-phenyl)-pyrrolidine-2,5-dione (ChemDiv., Inc., 4295-0309) 8: 3-Fluoro-benzoic acid 2,4-dibromo-6-{[2-(2-cyano-phenoxy)-acetyl]-hydrazonomethyl}-phenyl ester (ChemDiv., Inc., 8005-7568) 9:4-Methyl-3-{4-morρholin-4-yl-6-[N'-(2-nitro-benzylidene)-hydrazino]-[1, 3, 5]triazin-2-ylamino> -phenol (ChemDiv.

COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLSOVER-EXPRESSING BCL-2 FAMILY MEMBER PROTEINS

SCHWARTZ, PamelaS. [IL];MANION, MichaelK. [US];FRY, John S.[US];HOCKENBERY,David M. [US]; SCHWARTZ, PamelaS. [IL];MANION, MichaelK. [US];FRY, John S.[US];HOCKENBERY,David M. [US]

Score: 13.793969 | Text size: 86789 | Find: similardocuments

vendors thatprovide these compounds are Asinex (347,725 compounds), ChemBridge(411,532), ChemDiv(493,524 compounds), SPECS (261,875 compounds),Timtec (216,277 compounds), and CNC-2D (4,062,088

COMPOSITIONS AND METHODS FOR POTENTIATING ANTIBIOTIC ACTIVITY

COTTAREL,Guillaume [US]; GARDNER,Timothy, S. [US]; LEI, Xiaoguang[US];PORCO, John [US]; SCHAUS, Scott,E. [US];WIERZBOWSKI,Jamey [US];PAL, Kollol [US]; COTTAREL,Guillaume [US]; GARDNER,Timothy, S. [US]; LEI, Xiaoguang[US];PORCO, John [US]; SCHAUS, Scott,E. [US];WIERZBOWSKI,Jamey [US];PAL, Kollol [US]

Publicationdate: 2008-02-14 | Patent publication No.: WO-2008019292-A2|Assignees: TRUSTEES OF BOSTON UNIVERSITY [US] | IPC:C07D405/04; C07D487/04; C07D311/30; C07D311/16; C07D311/32; C07D231/56;C07D241/44; C07D261/16; C07D277/74; C07D307/68; C07D405/06; C07D495/04;A61K31/4035; A61K31/4196; A61K31/353 | Oldestpriority date: 2006-08-04 | Publication date: 2008-02-14

Score: 12.484504 | Text size: 131457 | Find: similardocuments

The ChemDiv compoundsare all combinatorial chemistry based and a large set of analogs are readilyavailable.

CRAC channel and modulator screening methods

D. Cahalan [US]; L. Zhang [US]; V. Yeromin [US]; D. Cahalan [US]; L. Zhang [US]; V. Yeromin [US]

Publicationdate: 2008-02-14 | Patent publication No.: US-20080039392-A1|Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US] | IPC: A01K67/00;A61K31/70; A61P35/00; C07K19/00; C12N15/00; C12N5/04; C12Q1/68; G01N33/53 | Oldest priority date: 2006-05-26 |Publicationdate: 2008-02-14

Score: 10.354719 | Text size: 259735 | Find: similardocuments

(San Diego,Calif.) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, Calif.

CYCLOPENTANECARBOXYLIC ACID DERIVATIVES AND THEIR USE IN THE TREATMENT OFBACTERIAL INFECTIOUS DISEASES

ORCHARD, MichaelGlen [GB];BENGHEZAL,Mohammed [CH]; BRAILLARD,Stéphanie [CH]; BURN, Christine[CH];DEUSCHEL,Christine [CH];LUCAS, Aurore[FR];VALENTINO,Emilio [CH];JANSSEN,Christian [SG]; BOYCE, Rustum S.[SG];ORCHARD, MichaelGlen [GB];BENGHEZAL,Mohammed [CH]; BRAILLARD,Stéphanie [CH]; BURN, Christine[CH];DEUSCHEL,Christine [CH]; LUCAS, Aurore[FR];VALENTINO,Emilio [CH];JANSSEN,Christian [SG]; BOYCE, Rustum S.[SG]

Publicationdate: 2008-02-14 | Patent publication No.: WO-2008017840-A1|Assignees: MERLION PHARMACEUTICALS SA [CH]; MERLION PHARMACEUTICALS PTE LTD [SG] | IPC: C07C229/46;C07C233/58; C07C233/59; C07C233/60; C07C233/63; C07C255/60; C07C311/46;C07D235/16; C07D277/82; C07D295/182; A61K31/192; A61K31/196; A61K31/165;A61K31/428; A61K31/4453 | Oldestpriority date: 2006-08-08 | Publication date: 2008-02-14

Score: 13.793969 | Text size: 84860 | Find: similardocuments

Sampledissolved in methanol. ^ Commercially available compound; (a) ChemDiv,Inc. of San Diego, CA, USA; (b) Vitas-M Laboratory, Moscow, Russia;(c) Asinex, Moscow, Russia.

HEME OXYGENASE INHIBITORS AND METHODS OF THERAPEUTIC USE

WILKS, Angela[US];MACKERELL, JR.,Alexander D. [US]; LOPES, Pedro[US];FURCI, Lena M.[US];WILKS, Angela[US];MACKERELL, JR.,Alexander D. [US]; LOPES, Pedro[US];FURCI, Lena M.[US]

Score: 13.793969 | Text size: 101498 | Find: similardocuments

wereselected for biological assay and purchased from ChemB ridge Corporation, SanDiego, CA.; ChemDiv Inc., San Diego, CA; Maybridge, Cornwall UK;and Specs, Cumberland, MD.

Prodrug antibiotic screens

Kim Lewis [US]; Gabriele Casadei[US];Kim Lewis [US]; Gabriele Casadei[US]

Publicationdate: 2008-01-31 | Patent publication No.: US-20080027044-A1|Assignees: Kim Lewis [US]; Gabriele Casadei [US] | IPC:A61K31/549; A61K31/17; A61K31/351; A61K31/381; A61K31/40; A61K31/403;A61P43/00; A61P31/00; A61K31/4184; A61K31/435; A61K31/498; A61K31/4985 | Oldest priority date: 2006-06-13 | Publication date: 2008-01-31

Score: 18.390068 | Text size: 276564 | Find: similardocuments

the NationalInstitutes of Health Molecular Library Screening Center, The ChemBridgeLibrary, the ChemDivLibrary, and the MayBridge Library. ... theNational Institutes of Health Molecular Library Screening Center, TheChemBridge Library, the ChemDiv Library, or the MayBridgeLibrary. ... the National Institutes of Health Molecular Library Screening Center,The ChemBridge Library, the ChemDiv Library, or the MayBridgeLibrary. ... Microformat 50,000 0686-0842 ChemDiv1 (Combilab and International)28,864 0587-0668 ChemDiv 2 8,560 1369-1393 ChemDiv 316,544 1473-1519 ChemDiv-Anti-Mitotic Collection 1,254 1157-1160 *CommercialDiversity Set 1

HEME OXYGENASE INHIBITORS AND METHODS OF THERAPEUTIC USE

WILKS, Angela[US];MACKERELL, JR.,Alexander D. [US]; LOPES, Pedro[US];FURCI, Lena M.[US];WILKS, Angela[US];MACKERELL, JR.,Alexander D. [US]; LOPES, Pedro[US];FURCI, Lena M.[US]

Score: 13.327991 | Text size: 131712 | Find: similardocuments

wereselected for biological assay and purchased from ChemB ridge Corporation, SanDiego, CA.; ChemDiv Inc., San Diego, CA; Maybridge, Cornwall UK;and Specs, Cumberland, MD.

SCREENING ASSAY FOR INHIBITORS OF TRPA1 ACTIVATION BY A LOWER ALKYLPHENOL

S. Paul, Lee[US];YANG, Qifeng[US];BRYANT, Robert,W. [US];BUBER, Tulu [US]; S. Paul, Lee[US];YANG, Qifeng[US];BRYANT, Robert,W. [US];BUBER, Tulu [US]

Score: 13.327991 | Text size: 101244 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, CA), Sigma-Aldrich (St.

COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY

KAZANTSEV,Aleksey G. [US]; KAZANTSEV,Aleksey G. [US]

Score: 12.685205 | Text size: 133132 | Find: similardocuments

Sourcesinclude Asinex (Moscow, Russia); Bionet (Camelford, England); ChemDiv (SanDiego, California); Comgenex (Budapest, Hungary); Enamine (Kiev, Ukraine); IFLab (Ukraine);

Compositions and methods for modulating sirtuin activity

Aleksey G.Kazantsev [US]; Aleksey G.Kazantsev [US]

Score: 12.892465 | Text size: 120999 | Find: similardocuments

Sourcesinclude Asinex (Moscow, Russia); Bionet (Camelford, England); ChemDiv (SanDiego, Calif.

INHIBITORS OF CYCLIC NUCLEOTIDE SYNTHESIS AND THEIR USE FOR THERAPY OFVARIOUS DISEASES

MURAD, Ferid[US];KOTS, Alexander,Y. [US];CHOI, Byung-Kwon[US];GUERRANT,Richard, L. [US]; MURAD, Ferid[US];KOTS, Alexander,Y. [US];CHOI, Byung-Kwon[US];GUERRANT, Richard,L. [US]

Score: 13.793969 | Text size: 74972 | Find: similardocuments

Thecompounds were purchased from ChemDiv, Inc., San Diego, CA.

ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

WELSH, William,J. [US];WANG, Ching Y.,Nina [US];AL, Ni [US]; WELSH, William,J. [US];WANG, Ching Y.,Nina [US];AL, Ni [US]

Score: 17.397278 | Text size: 50487 | Find: similardocuments

compoundwherein R4 is OH and R5 is H is referred to herein as "Compound B" or"3257-4404" (ChemDiv, Inc., San Diego, California). ... Louis,Missouri), Maybridge (Geel, Belgium), and ChemDiv, Inc. (SanDiego, California).

INHIBITORS OF USP1 DEUBIQUITINATING ENZYME COMPLEX

D'ANDREA, Alan [US]; D'ANDREA, Alan[US]

Score: 11.918776 | Text size: 160822 | Find: similardocuments

consists ofknown bioactive libraries, natural product libraries, and commercial librariessuch as ChemDiv, ChemBridge etc.

Antiviral methods and compositions

M. Coen [US]; Arianna Loregian[US];M. Coen [US]; Arianna Loregian[US]

Publicationdate: 2007-09-27 | Patent publication No.: US-20070225310-A1|Assignees: M. Coen [US]; Arianna Loregian [US] | IPC:A61K31/505; A61K31/04; A61K31/12; A61K31/41; A61K31/415 | Oldest priority date: 2004-07-14 | Publication date: 2007-09-27

Score: 15.290299 | Text size: 156385 | Find: similardocuments

screen thePeakdale (2,816 compounds), Bionet (4,800 compounds), Maybridge (8,800compounds), andChemDiv (28,864 compounds) libraries, and 4,348compounds out of the 50,000 of the Chembridge Microformat ... high throughputscreening, small molecules (5 mg/ml in DMSO) of the Maybridge, Bionet,Peakdale, ChemDiv, and Chembridge Microformat libraries wereobtained from the ICCB, and 100 nl of each compound were

Wnt Pathway Antagonists

A. Beachy [US]; K. Chen [US]; K. Mann [US]; A. Beachy [US]; K. Chen [US]; K. Mann [US]

Publicationdate: 2007-09-20 | Patent publication No.: US-20070219257-A1|Assignees: A. Beachy [US]; K. Chen [US]; K. Mann [US] | IPC:A61K31/4192; C07D211/08; C07D249/24; C07D487/04; C12N5/06; C12N5/08;C12Q1/06; C12Q1/18 | Oldestpriority date: 2004-09-29 |Publicationdate: 2007-09-20

Score: 12.290053 | Text size: 134806 | Find: similardocuments

format and,using pin transfers on Biomek FX robotics (Beckman), we screened 40,000compounds fromChemDiv and ChemBridge collections (at aconcentration of approx.

Methods for identifying modulators of hedgehog autoprocessing

Xingbin Ai [US]; Charles Emerson[US];Henry Paulus[US];Xingbin Ai [US]; Charles Emerson[US];Henry Paulus[US]

Publicationdate: 2007-09-13 | Patent publication No.: US-20070212712-A1|Assignees: Xingbin Ai [US]; Charles Emerson [US]; Henry Paulus [US] | IPC: C12Q1/68;C12Q1/66; C12Q1/37; C07F9/80 | Oldest prioritydate: 2005-12-05 | Publication date: 2007-09-13

Score: 14.692947 | Text size: 58816 | Find: similardocuments

(5,056reagents), Diversity Oriented Synthesis (16,030 reagents), ICCB Bioactives (489reagents), ChemDivCombilab/Intemational (28,864 reagents), Bionet(6,168 reagents), Maybridge (16,807 reagents),

Pharmaceutical compositions comprising anti-inflammatoryquinazolinecarboxamide derivatives

Paul Gregor [IL]; Nicholas Harris[IL];Juraj Koppel[SK];Regina Zhuk [IL]; Paul Gregor [IL]; Nicholas Harris[IL];Juraj Koppel[SK];Regina Zhuk [IL]

Score: 15.906768 | Text size: 115904 | Find: similardocuments

Compoundswere synthesized or purchased from suppliers of chemical compounds suchas ChemDiv Labs (San Diego, Calif. ... The compound collectionwas purchased from ChemDiv Inc. (San Diego, Calif.

Screening of anti-viral drugs and pharmaceuticals composition containingthiazolidinone derivatives

Paul Gregor [IL]; Nicholas Harris[IL];Regina Zhuk [IL]; Paul Gregor [IL]; Nicholas Harris[IL];Regina Zhuk [IL]

Publicationdate: 2007-08-02 | Patent publication No.: US-20070179137-A1|Assignees: RIMONYX PHARMACEUTICALS LTD. [IL] | IPC:A61K31/5377; A61K31/519; A61K31/427; C07D487/04; C07D417/02; C12Q1/70 | Oldest priority date: 2004-03-24 | Publication date: 2007-08-02

Score: 13.327991 | Text size: 86373 | Find: similardocuments

Thecompounds were purchased from ChemDiv Inc. (San Diego, Calif.

3,4-diarylpyrazoles and their use in the therapy of cancer

Martin JamesDrysdale [GB]; Brian WilliamDymock [GB];XavierBarril-Alonso [GB]; Paul Workman[GB];Laurence HarrisPearl [GB];ChrisostomosProdromou [GB]; Edward McDonald[GB];Martin JamesDrysdale [GB]; Brian WilliamDymock [GB];XavierBarril-Alonso [GB]; Paul Workman[GB];Laurence HarrisPearl [GB];ChrisostomosProdromou [GB]; Edward McDonald[GB]

Publicationdate: 2007-07-24 | Patent publication No.: US-07247734-B2|Assignees: Vernalis (Cambridge) Limited [GB]; Cancer Research Technology Ltd. [GB];Institute of Cancer Research of Royal Cancer Hospital [GB] | IPC: C07D231/10 | Oldest priority date: 2001-12-21 |Publicationdate: 2007-07-24

Score: 9.838301 | Text size: 335791 | Find: similardocuments

examples ofcompounds of the present invention were obtained from commercial sources(e.g., ChemDiv Inc., San Diego, Calif., USA).

SMALL MOLECULE INHIBITORS OF PDZ INTERACTIONS

BELMARES,Michael, P. [US]; LU, Peter, S.[US];MENDOZA,Kenneth, A. [US]; BELMARES,Michael, P. [US]; LU, Peter, S.[US];MENDOZA,Kenneth, A. [US]

Score: 15.906768 | Text size: 132566 | Find: similardocuments

Methods and compositions for diagnosis and treatment of influenza

S. Lu [US]; D. Rabinowitz[US];P. Belmares [US]; S. Lu [US]; D. Rabinowitz[US];P. Belmares [US]

Score: 8.94598 | Text size: 375767 | Find: similardocuments

software(Accelrys, San Diego, Calif.) was used to model and dock a 650,000 moleculelibrary (ChemDiv, San Diego, Calif.; Blanca Pharmaceuticals, MountainView, Calif.

INTEGRIN-BINDING SMALL MOLECULES

Nouri NEAMATI[US];Raveendra DAYAM[US];Nouri NEAMATI[US];Raveendra DAYAM[US]

Score: 14.719831 | Text size: 193900 | Find: similardocuments

A search ofthe Chemical Diversity (ChemDiv, Inc, San Diego, Calif.) database of359,224 compounds produced 148 hits. ... The novel drug candidates (NVX-188 andanalogues) are synthesized by and purchased fromChemDiv (San Diego,Calif.). Compounds are stored as 1 mM stock solutions in DMSO at −20° C.until use.

Novel therapeutic target for protozoal diseases

DharmenderRathore [US]; Dewal Jani [US]; Rana Nagarkatti[US];DharmenderRathore [US]; Dewal Jani [US]; Rana Nagarkatti[US]

Publicationdate: 2007-06-28 | Patent publication No.: US-20070148185-A1|Assignees: Dharmender Rathore [US]; Dewal Jani [US]; Rana Nagarkatti [US] | IPC: A61K39/00;A61K31/7024; A61K31/538; A61K31/5377; A61K31/4709; A61K31/4706 | Oldest priority date: 2006-10-13 |Publicationdate: 2007-06-28

Score: 10.354719 | Text size: 366170 | Find: similardocuments

from severalsources including established chemical vendors (Asinex, Analyticon, Biomol,Bionet, ChemDiv, Enamine, Maybridge, Spectrum, TimTec) as well as arange of diversity oriented synthesis compounds

Antiviral Compositions and Methods

Yuan-Ping Pang[US];J. Dooley [US]; Giew Park [US]; Yuan-Ping Pang[US];J. Dooley [US]; Giew Park [US]

Publicationdate: 2007-06-28 | Patent publication No.: US-20070149487-A1|Assignees: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH [US] | IPC: A61K31/655;A61K31/47; A61K31/403; A61K31/381; A61K31/343 | Oldest priority date: 2005-11-08 | Publication date: 2007-06-28

Score: 16.234026 | Text size: 98336 | Find: similardocuments

herein maybe obtained from commercial sources (e.g., Asinex, Array BioPharma, Bionet,ChemBridge,ChemDiv, Enamine, Interbioscreen, Microchem Ltd, Maybridge,Peakdale, Sigma-Aldrich, Specs Biospecs, and ... All tested compounds werepurchased from Asinex, Array BioPharma, Bionet, ChemBridge, ChemDiv,Enamine, Interbioscreen, Microchem Ltd, Maybridge, Peakdale, Sigma-Aldrich,Specs Biospecs, and

Methods of treating secretory diarrhea using cystic fibrosis transmembraneconductance regulator protein inhibitors

Alan Verkman[US];Tonghui Ma [US]; Alan Verkman[US];Tonghui Ma [US]

Score: 12.290053 | Text size: 137501 | Find: similar documents

Structure-activityanalysis was done on analogs purchased from ChemBridge and ChemDiv (SanDiego, Calif.

METHODS FOR IDENTIFYING MODULATORS OF HEDGEHOG AUTOPROCESSING

HENRY, Paulus[US];XINGBIN, Ai [US]; CHARLES, Emerson[US]

Score: 14.692947 | Text size: 60430 | Find: similardocuments

(5,056reagents), Diversity Oriented Synthesis (16,030 reagents), ICCB Bioactives (489reagents), ChemDivCombilab/International (28,864 reagents), Bionet(6,168 reagents), Maybridge (16,807 reagents),

SOUR/ACID TASTE RECEPTOR ASSAYS, GENES AND PROTEINS

ZUKER, Charles[US];HUANG, Angela,L. [US];ZUKER, Charles[US];HUANG, Angela,L. [US]

Score: 10.354719 | Text size: 274618 | Find: similardocuments

(San Diego,CA) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, CA) providing a variety ofcompound diversity libraries including CombiLab and the

INTEGRIN-BINDING SMALL MOLECULES

NEAMATI, Nouri[US];DAYAM, Raveendra[US];NEAMATI, Nouri[US];DAYAM, Raveendra[US]

Score: 14.999643 | Text size: 192727 | Find: similardocuments

A search ofthe Chemical Diversity (ChemDiv, Inc, San Diego, CA) database of 3δ9,224compounds produced 148 hits. ... The novel drug candidates (NVX-188 andanalogues) are synthesized by and purchased fromChemDiv (San Diego,CA). Compounds are stored as 1 mM stock solutions in DMSO at -200C until use.

HIGH THROUGHPUT SCREENING ASSAY FOR THE TRPM5 ION CHANNEL

BRYANT, RobertW. [US];LEE, S. Paul[US];PALMER, R. Kyle[US];YANG, Qifeng[US];BUBER, M. N.Tulu [US];BRYANT, RobertW. [US];LEE, S. Paul[US];PALMER, R. Kyle[US];YANG, Qifeng[US];BUBER, M. N.Tulu [US]

Score: 13.793969 | Text size: 82143 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, CA), Sigma-Aldrich (St.

Inositol compounds and uses of same in the treatment of diseasescharacterized by abnormal protein folding or aggregation or amyloid formation,desposition, accumulation or persistence

Antonio Cruz[CA];Linda Kurdydyk[CA];Antonio Cruz[CA];Linda Kurdydyk[CA]

Publicationdate: 2007-05-17 | Patent publication No.: US-20070111970-A1|Assignees: Antonio Cruz [CA]; Linda Kurdydyk [CA] | IPC:A61K31/66; A61K31/16; A61K31/075; A61K31/045 | Oldest priority date: 2005-10-13 | Publication date: 2007-05-17

Score: 19.0931 | Text size: 225803 | Find: similardocuments

C 55.37% H7.75% O 36.88% IRL 2 [[image:EMI-C00193]] C 58.53% H 4.91% N 17.06% O19.49% ChemDiv 0 [[image:EMI-C00194]] C 67.82% H 4.38% O 27.80% ChemDiv 0[[image:EMI-C00195]] C 53.83% H 7.74% N 17.94% O 20.49% ChemDiv 0[[image:EMI-C00196]] C 48.00% H 5.37% N 9.33% O 37.30% ChemDiv 0[[image:EMI-C00197]] C 45.22% H 4.74% Cl 11.12% N 8.79% O 30.12% ChemDiv 0[[image:EMI-C00198]] C 49.75% H 5.57% Cl 12.24% N 4.83% O 27.61% ChemDiv 0[[image:EMI-C00199]] C 49.68% H 5.77% N 8.91% O 35.63% ChemDiv 0+00 [[image:EMI-C00200]] C 49.75% H 5.57% Cl 12.24% N 4.83% O 27.61% ChemDiv 0[[image:EMI-C00201]] C 43.13% H 4.83% Br 23.91% N 4.19% O 23.94% ChemDiv 0[[image:EMI-C00202]] C 56.33% H 7.09% N 6.57% O 30.01% ChemDiv 0[[image:EMI-C00203]] C 66.93% H 11.70% N 6.50% O 14.

High throughput screening assay for the TRPM5 ion channel

W. Bryant [US]; Paul Lee [US]; Kyle Palmer [US]; Qifeng Yang [US]; Tulu Buber [US]; W. Bryant [US]; Paul Lee [US]; Kyle Palmer [US]; Qifeng Yang [US]; Tulu Buber [US]

Publicationdate: 2007-05-17 | Patent publication No.: US-20070111264-A1|Assignees: W. Bryant [US]; Paul Lee [US]; Kyle Palmer [US]; Qifeng Yang [US]; TuluBuber [US] | IPC: G01N33/567 | Oldestpriority date: 2005-11-03 | Publication date: 2007-05-17

Score: 13.793969 | Text size: 80264 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES

RATHORE,Dharmendar [US]; JANI, Dewal [US]; NAGARKATTI, Rana[US];RATHORE,Dharmendar [US]; JANI, Dewal [US]; NAGARKATTI, Rana[US]

Score: 10.354719 | Text size: 341357 | Find: similardocuments

Method for identifying inhibitors of G protein coupled receptor signaling

AnnetteGilchrist [US]; Heidi M. Hamm[US];AnnetteGilchrist [US]; Heidi M. Hamm[US]

Score: 12.484504 | Text size: 167127 | Find: similardocuments

Methods for reducing plateletactivation platelet aggregaton or thrombosis

Robert CharlesFlaumenhaft [US]; Robert CharlesFlaumenhaft [US]

Score: 14.999643 | Text size: 166228 | Find: similardocuments

from thecompound 3-(acetyloxy)-4,4,4-trichloro-1-(2,4-dichlorophenyl)-1-butanone,available from ChemDiv, Inc. (San Diego, Calif.), Contact ServiceCo. ... Synthesis, Inc., Enamine, AsInEx, Aldrich Chemical Company, Inc.(Milwaukee, Wis.), and ChemDiv, Inc. Compounds having H or NO2at R1 and/or H, alkyl, aralkyl, alkenyl, cycloalkyl, cycloalkenyl and

MAMMALIAN SOUR/ ACID TASTE AND CSF RECEPTOR GENES, POLYPEPTIDES ANDASSAYS

ZUKER, Charles[US];HUANG, Angela,L. [US];ZUKER, Charles[US];HUANG, Angela,L. [US]

Score: 10.633806 | Text size: 271291 | Find: similardocuments

(San Diego,CA) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, CA) providing a variety of compounddiversity libraries including CombiLab and the

Novel ion channel preferentially expressed in mammalian taste receptorcells

Charles Zucker[US];L. Huang [US]; Charles Zucker[US];L. Huang [US]

Score: 11.918776 | Text size: 171358 | Find: similardocuments

(San Diego,Calif.) including a wide array of targeted or general and custom or stocklibraries; ChemDiv (San Diego, Calif.

INHIBITORS OF EPSTEIN BARR VIRUS NUCLEAR ANTIGEN 1

KIEFF, Elliott[US];KANG, Myung-Soo[US];KIEFF, Elliott[US];KANG, Myung-Soo[US]

Score: 18.651087 | Text size: 104389 | Find: similardocuments

Examples oflibraries are those provided by ChemDiv, Inc. (San Diego, CA),The ChemBridge Corporation Library (ChemBridge Corporation, San Diego, CA), the... ChemDiv, Inc. provides custom libraries for discovery orhit profiling. ... of Chemistry and Cell Biology (ICCB) facilities and 44,000compounds including Bioactive NINDS, ChemDiv, Chembridge, and NCIopen libraries. ... The initial screen of a diverse ChemDiv (SanDiego, CA) combilab 28,864 component chemical library required approximately200 plates for

FUSED QUINAZOLINONE DERIVATIVES AND USES THEREOF

GREGOR, Paul[IL];HARRIS, Nicholas[IL];ZHUK, Regina[IL];KOPPEL, Juraj[SK];GREGOR, Paul[IL];HARRIS, Nicholas[IL];ZHUK, Regina[IL];KOPPEL, Juraj[SK]

Score: 13.556976 | Text size: 100929 | Find: similardocuments

The testcompound (synthesized or purchased from suppliers of chemical compounds suchas ChemDiv Labs.

Bis-aromatic amides and their uses as sweet flavor modifiers, tastants,and taste enhancers

CatherineTachdjian [US]; P. Patron [US]; Farid Bakir [US]; Claudia Averbuj[US];Chad Priest [US]; L.Adamski-Werner [US]; Qing Chen [US];VincentDarmohusodo [US]; MarketaLebl-Rinnova [US]; D. A. Kimmich[US];Xiao-Qing Tang[US];Rhondi Shigemura[US];CatherineTachdjian [US]; P. Patron [US]; Farid Bakir [US]; Claudia Averbuj[US];Chad Priest [US]; L.Adamski-Werner [US]; Qing Chen [US]; VincentDarmohusodo [US]; MarketaLebl-Rinnova [US]; D. A. Kimmich[US];Xiao-Qing Tang[US];Rhondi Shigemura[US]

Publicationdate: 2007-01-04 | Patent publication No.: US-20070003680-A1|Assignees: Catherine Tachdjian [US]; P. Patron [US]; Farid Bakir [US]; Claudia Averbuj[US]; Chad Priest [US]; L. Adamski-Werner [US]; Qing Chen [US]; VincentDarmohusodo [US]; Marketa Lebl-Rinnova [US]; D. A. Kimmich [US]; Xiao-Qing Tang[US]; Rhondi Shigemura [US] | IPC: A23L1/236 | Oldest prioritydate: 2005-06-15 | Publication date:2007-01-04

Score: 9.370946 | Text size: 316072 | Find: similardocuments

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

BIS-AROMATIC AMIDES AND THEIR USES AS SWEET FLAVOR MODIFIERS, TASTANTSAND TASTE ENHANCERS

TACHDJIAN,Catherine [US]; PATRON, Andrew,P. [US];BAKIR, Farid[US];AVERBUJ, Claudia[US];PRIEST, Chad[US];ADAMSKI-WERNER,Sara, L. [US]; CHEN, Qing [US]; DARMOHUSODO,Vincent [US]; LEBL-RINNOVA,Marketa [US]; KIMMICH, Rachel,D., A. [US];TANG, Xiao-Qing[US];SHIGEMURA,Rhondi [US];TACHDJIAN,Catherine [US]; PATRON, Andrew,P. [US];BAKIR, Farid[US];AVERBUJ, Claudia[US];PRIEST, Chad[US];ADAMSKI-WERNER,Sara, L. [US]; CHEN, Qing [US]; DARMOHUSODO,Vincent [US]; LEBL-RINNOVA,Marketa [US]; KIMMICH, Rachel,D., A. [US];TANG, Xiao-Qing[US];SHIGEMURA,Rhondi [US]

Publicationdate: 2006-12-28 | Patent publication No.: WO-2006138512-A2|Assignees: SENOMYX, INC. [US] | IPC: C07C233/01; A23L2/39; A23L2/60; A23G3/36; A23G9/32; A23L1/236; A23L1/164 | Oldest priority date: 2005-06-15 | Publication date: 2006-12-28

Score: 9.370946 | Text size: 313113 | Find: similardocuments

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia PA, ChemDiv of San Diego, CA, Chembridge of SanDiego, California, Asinex of Moscow, Russia, SPECS/BIOSPECS of

L-SIGN polymorphisms and methods involving use of same

P. Gardner [GB]; C. Olson [US]; P. Gardner [GB]; C. Olson [US]

Score: 14.999643 | Text size: 216376 | Find: similardocuments

Forexample, ChemDiv (San Diego, Calif. ... ChemDiv hasa large number of small molecules that are usable as building blocks foridentifying and

PHARMACOLOGICAL CHAPERONES FOR TREATING OBESITY

FAN, Jian-qiang[US];VANLENZANO, Ken[US];LEE, Gary [US]; BOUVIER, Michel[CA];FAN, Jian-qiang[US];VANLENZANO, Ken[US];LEE, Gary [US]; BOUVIER, Michel[CA]

Publicationdate: 2006-12-14 | Patent publication No.: WO-2006133098-A2|Assignees: AMICUS THERAPEUTICS, INC. [US] | IPC:C07K14/72;C12N5/06; A61K31/505; A61K31/495; A61K31/4164 | Oldest priority date: 2005-06-03 | Publication date: 2006-12-14

Score: 17.126425 | Text size: 136065 | Find: similardocuments

Methods of screening for anti-inflammatory drugs and use thereof

Paul Gregor [IL]; Nicholas Harris[IL];Juraj Koppel[SK];Paul Gregor [IL]; Nicholas Harris[IL];Juraj Koppel[SK]

Publicationdate: 2006-12-07 | Patent publication No.: US-20060275214-A1|Assignees: Rimonyx Pharmaceuticals LTD. [IL] | IPC:A61K51/00; G01N33/53; G01N33/574; A61K38/16; A61K31/737; A61K31/727; A61K39/395;C07K16/30 | Oldestpriority date: 2003-12-30 |Publicationdate: 2006-12-07

Score: 12.685205 | Text size: 116838 | Find: similardocuments

A diversecollection of small molecule compounds was purchased from ChemDiv Inc. (SanDiego, Calif.). Compounds were dissolved in DMSO at 10 mM and further dilutedprior to assay.

Compounds comprising linked heteroaryl moieties and their use as novelumami flavor modifiers, tastants and taste enhancers for comestiblecompositions

CatherineTachdjian [US]; MarketaLebl-Rinnova [US]; David Wallace[US];CatherineTachdjian [US]; MarketaLebl-Rinnova [US]; David Wallace[US]

Publicationdate: 2006-11-23 | Patent publication No.: US-20060263411-A1|Assignees: Catherine Tachdjian [US]; Marketa Lebl-Rinnova [US]; David Wallace [US] | IPC: A61K47/00;A23L1/22; A23L2/56 | Oldestpriority date: 2005-02-04 | Publication date: 2006-11-23

Score: 10.633806 | Text size: 210019 | Find: similardocuments

other wellknown chemical suppliers such as Fisher Scientific, TCI America ofPhiladelphia, Pa., ChemDiv of San Diego, Calif., Chembridge ofSan Diego, Calif.

Methods for identifying small molecules that modulate prematuretranslation termination and nonsense mediated mrna decay

M. Welch [US]; Gregory Almstead[US];F. Rando [US]; C. Pellegrini[US];M. Welch [US]; Gregory Almstead[US];F. Rando [US]; C. Pellegrini[US]

Publicationdate: 2006-11-16 | Patent publication No.: US-20060257866-A1|Assignees: M. Welch [US]; Gregory Almstead [US]; F. Rando [US]; C. Pellegrini [US] | IPC: C40B30/06;C12Q1/68 | Oldestpriority date: 2002-07-24 | Publication date: 2006-11-16

Score: 7.2924438 | Text size: 493583 | Find: similardocuments

Molecules comprising linked organic moieties as flavor modifiers forcomestible compositions

CatherineTachdjian [US]; P. Patron [US]; MarketaLebl-Rinnova [US]; Xiao-Qing Tang[US];VincentDarmohusodo [US]; Chad Priest [US]; CatherineTachdjian [US]; P. Patron [US]; MarketaLebl-Rinnova [US]; Xiao-Qing Tang[US];VincentDarmohusodo [US]; Chad Priest [US]

Publicationdate: 2006-11-16 | Patent publication No.: US-20060257543-A1|Assignees: Catherine Tachdjian [US]; P. Patron [US]; Marketa Lebl-Rinnova [US];Xiao-Qing Tang [US]; Vincent Darmohusodo [US]; Chad Priest [US] | IPC: A23L1/22 | Oldest priority date: 2005-02-04 |Publicationdate: 2006-11-16

Score: 9.370946 | Text size: 269894 | Find: similardocuments

and otherwell know suppliers such as Fisher Scientific, TCI America of Philadelphia,Pa., ChemDiv of San Diego, Calif., Chembridge of San Diego,Calif.

DIHYDROPYRIDINE DERIVATIVES

VAN STRATEN,Nicole, Corine, Renee [NL]; GERRITSMA,Gerritdina, Geziena [NL]; VAN DER VEEN,Lars, Anders [NL]; VAN STRATEN,Nicole, Corine, Renee [NL]; GERRITSMA,Gerritdina, Geziena [NL]; VAN DER VEEN,Lars, Anders [NL]

Score: 14.424358 | Text size: 65279 | Find: similardocuments

NOVEL CHEMICAL INHIBITORS OF NEUTROPHIL ACTIVATION THROUGH THESAC-DEPENDENT PATHWAY

NATHAN, Carl, F.[US];BUCK, Jochen[US];LEVIN, Lonny, R.[US];HAN, Hyunsil[US];NATHAN, Carl, F.[US];BUCK, Jochen[US];LEVIN, Lonny, R.[US];HAN, Hyunsil[US]

Score: 13.793969 | Text size: 81836 | Find: similardocuments

AssayScreening [0047] A collection of 15,000 compounds with drug-likecharacteristics from ChemDiv Labs (San Diego, CA) was screenedrobotically in the High Throughput Screening Facility at

Methods for identifying small molecules that bind specific RNA structuralmotifs

F. Rando [US]; Ellen Welch [US]; F. Rando [US]; Ellen Welch [US]

Score: 11.918776 | Text size: 253358 | Find: similardocuments

INHIBITORS OF NEUROTRYPSIN AND DETERMINATION THEREOF

SONDEREGGER,Peter [CH];HETTWER, Stefan[CH];BOLLIGER, Marc,F. [CH];DREIER, Birgit[CH];KUNZ, Beat [CH]; LÜSCHER,Daniel [CH];REIF, Raymond[CH];SALES, Susanne[CH];SONDEREGGER,Peter [CH];HETTWER, Stefan[CH];BOLLIGER, Marc,F. [CH];DREIER, Birgit[CH];KUNZ, Beat [CH]; LÜSCHER,Daniel [CH];REIF, Raymond[CH];SALES, Susanne[CH]

Score: 11.918776 | Text size: 160239 | Find: similardocuments

Compound No.7 (identification number 1672-3440 from ChemDiv, San Diego, CA,USA, N1-amidino-N4-(3,5-dibromosalicylidene)-sulfanilamide, IUPAC name:

Novel splice variants of human epithelial sodium channel genes expressedin human taste tissue and uses thereof

Bryan Moyer [US]; FernandoEcheverri [US]; Min Lu [US]; Bianca Laita[US];Bryan Moyer [US]; FernandoEcheverri [US]; Min Lu [US]; Bianca Laita[US]

Score: 13.793969 | Text size: 160505 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, Calif.), Sigma-Aldrich (St.Louis, Mo.

INHIBITORS FOR EXTRACELLULAR SIGNAL-REGULATED KINASE DOCKING DOMAINS ANDUSES THEREFOR

SHAPIRO, Paul[US];MACKERREL,Alexander [US]; SHAPIRO, Paul[US];MACKERREL,Alexander [US]

Score: 13.10661 | Text size: 110237 | Find: similardocuments

Compounds17, 36, 67-68, 76, and 79-81 selected via CADD were purchased from ChemDiv (SanDiego, CA) or ChemBridge (San Diego, CA) and dissolved in DMSO at a stockconcentration of 25,

INHIBITORS OF NEUROTRYPSIN AND DETERMINATION THEREOF

Score: 11.918776 | Text size: 160359 | Find: similardocuments

Compound No.7 (identification number 1672-3440 from ChemDiv, San Diego, CA,USA, N1-amidino-N4-(3,5-dibromosalicylidene)-sulfanilamide, IUPAC name:

Structural requirements for STAT3binding and recruitment to phosphotyrosine ligands

J. Tweardy [US]; J. Tweardy [US]

Score: 11.569273 | Text size: 184771 | Find: similardocuments

Chemicaldatabases were obtained from ChemBridge, Asinex, ChemDiv, Enamine,KeyOrganics and LifeChemicals.

STRUCTURAL REQUIREMENTS FOR STAT3 BINDING AND RECRUITMENT TO PHOSPHOTOTYROSINELIGANDS

TWEARDY, DavidJ. [US];TWEARDY, DavidJ. [US]

Publicationdate: 2006-06-29 | Patent publication No.: WO-2006069001-A2|Assignees: BAYLOR COLLEGE OF MEDICINE [US] | IPC:C07K1/00;C07K4/00; C07K7/00; C07K7/08; A61K38/00; A61K38/03; A61K38/12 | Oldest priority date: 2004-12-20 | Publication date: 2006-06-29

Score: 11.918776 | Text size: 186392 | Find: similardocuments

Chemicaldatabases were obtained from ChemBridge, Asinex, ChemDiv, Enamine,KeyOrganics and LifeChemicals.

Repairing or replacing tissues or organs

K Jain [US]; Dai Fukumura[US];K Jain [US]; Dai Fukumura[US]

Score: 11.918776 | Text size: 137879 | Find: similardocuments

are commerciallyavailable from Nanoscale Combinatorial Synthesis Inc., Mountain View,Calif., ChemDiv Inc., San Diego, Calif., Pharmacopeia DrugDiscovery, Princeton, N.J., and ArQule Inc., Medford, Mass.

Pharmaceutical compositions comprising thieno[2,3-c]pyridine derivativesand use thereof

Paul Gregor [IL]; Nicholas Harris[IL];Juraj Koppel[SK];Regina Zhuk [IL]; Paul Gregor [IL]; Nicholas Harris[IL];Juraj Koppel[SK];Regina Zhuk [IL]

Score: 12.290053 | Text size: 148489 | Find: similardocuments

Compoundswere synthesized or purchased from ChemDiv Labs (San Diego,Calif.

POLYPEPTIDES INVOLVED IN CANDIDA BIOFILM FORMATION AND USES THEREOF

JANBON, Guilhem[FR];IRAQUIHOUSSAINI, Ismail [FR]; D'ENFERT,Christophe, Didier [FR]; JANBON, Guilhem[FR];IRAQUIHOUSSAINI, Ismail [FR];D'ENFERT, Christophe, Didier [FR]

Score: 16.750965 | Text size: 116606 | Find: similardocuments

of in vivoinhibitors ofbiofilm formation in Candida The kinase focused collection (ChemDiv,Inc) will be screened to select inhibitors of biofilm formation in aYakip-dependent or -independent ... A collection of 3000 molecules of thekinase focused library will be selected (ChemDiv, Inc) and tested fortheir inhibitory potency on the Yak1 activity.

Biaryloxymethylarenecarboxylic acids as glycogen synthase activators

Paul Gillespie[US];Alan Goodnow[US];Wright Tilley[US];Paul Gillespie[US];Alan Goodnow[US];Wright Tilley[US]

Publicationdate: 2006-06-08 | Patent publication No.: US-20060122256-A1|Assignees: Paul Gillespie [US]; Alan Goodnow [US]; Wright Tilley [US] | IPC: A61K31/381;A61K31/34; A61K31/192 | Oldest prioritydate: 2004-12-03 | Publication date: 2006-06-08

Score: 17.251234 | Text size: 151117 | Find: similardocuments

Specs andBiospecs, Rijswijk, phenol Netherlands2-(3,5-Dimethyl-pyrazol-1-yl)phenol ChemDiv, Inc. San Diego,CA 4-(5-Methyl-furan-2-yl)-phenol ChemDiv, Inc. San Diego, CA1-Phenyl-1H-5-(5′-chloro-2′hydroxy-4′methylphenyl)pyrazoleAldrich Chemical Company, Inc., Milwaukee, WI 2-(3,5-Dimethyl-1-phenyl-1Hpyrazol-4-yl)-phenol ChemDiv,Inc. San Diego, CA Compounds of formula 4 that are not known in theliterature may be prepared using

PROSTAGLANDIN EP4 ANTAGONISTS

WHEELER, Larry,A. [US];GARST, Michael,E. [US];LIANG, Yanbin[US];WOODWARD, David,F. [US];KRAUSS, Achim,H.P [US];BURK, Robert, M.[US];DONDE, Yariv[US];HOLOBOSKI, Mark[US];OLD, David, W.[US];CHEN, June [US]; WHEELER, Larry,A. [US];GARST, Michael,E. [US];LIANG, Yanbin[US];WOODWARD, David,F. [US];KRAUSS, Achim,H.P [US];BURK, Robert, M.[US];DONDE, Yariv[US];HOLOBOSKI, Mark[US];OLD, David, W.[US];CHEN, June [US]

Score: 15.115125 | Text size: 33172 | Find: similardocuments

Thesecompounds can be purchased from several companies including ChemDiv.

Prostaglandin EP4 antagonists

A. Wheeler [US]; E. Garst [US]; Yanbin Liang[US];David Woodward[US];H. P. Krauss[US];M. Burk [US]; Yariv Donde [US]; Mark Holoboski[US];W. Old [US]; June Chen [US]; A. Wheeler [US]; E. Garst [US]; Yanbin Liang [US]; David Woodward[US];H. P. Krauss[US];M. Burk [US]; Yariv Donde [US]; Mark Holoboski[US];W. Old [US]; June Chen [US]

Score: 15.115125 | Text size: 31908 | Find: similar documents

Thesecompounds can be purchased from several companies including ChemDiv.

Small molecules that replace or agonize p53 function

ShahroozRabizadeh [US]; Kayvan Niazi[US];E. Bredesen [US]; ShahroozRabizadeh [US]; Kayvan Niazi[US];E. Bredesen [US]

Score: 18.534403 | Text size: 47120 | Find: similardocuments

Compositions and methods for inhibiting mucin-type O-linked glycosylation

R. Bertozzi [US]; C. Hang [US]; R. Bertozzi [US]; C. Hang [US]

Score: 12.290053 | Text size: 140723 | Find: similardocuments

Aldehydeswere purchased from Aldrich, ChemDiv or ChemBlock as listed inthe Supplementary Material.

USE OF STEM CELLS TO GENERATE INNER EAR CELLS

LI, Huawei [CN]; EDGE, Albert[US];HELLER, Stefan[US];LI, Huawei [CN]; EDGE, Albert[US];HELLER, Stefan[US]

Score: 12.290053 | Text size: 132427 | Find: similardocuments

commerciallyavailable compound libraries (suppliers include ChemBridge Corp (San Diego, CA)and ChemDiv(San Diego, CA)).

TETRAHYDROQUINOLINE DERIVATIVES

VAN STRATEN,Nicole Corine Renée, N.V. Organon [NL]; VAN SOMEREN,Rudolf Gijsbertus, N.V. Organon [NL]; SCHULZ, Jurgen,Organon Laboratories Ltd. [GB]

Publicationdate: 2006-03-08 | Patent publication No.: EP-1406628-B1|Assignees: Akzo Nobel N.V. [NL] | IPC: A61K31/47; C07D215/38; C07D401/12; C07D405/14; C07D417/12; C07D215/48;C07D215/20; C07D215/08; C07D413/12; A61K31/4709; A61P5/06 | Oldest priority date:2001-07-02 | Publication date: 2006-03-08

Score: 13.327991 | Text size: 128753 | Find: similardocuments

(CAS310456-97-4), -A0705/0032919 (CAS 327981-38-4) and 4723-A1028/0048172 (CAS339273-93-7);ChemDiv.

External link

SMALL MOLECULES THAT REPLACE OR AGONIZE P53 FUNCTION

RABIZADEH,Shahrooz [US]; NIAZI, Kayvan[US];BREDESEN, Dale,E. [US];RABIZADEH,Shahrooz [US]; NIAZI, Kayvan[US];BREDESEN, Dale,E. [US]

Score: 18.534403 | Text size: 48237 | Find: similardocuments

Aromatic amides and ureas and their uses as sweet and/or umami flavormodifiers, tastants and taste enhancers

CatherineTachdjian [US]; P. Patron [US]; Ming Qi [CN]; L.Adamski-Werner [US]; Xiao-Qing Tang[US];Qing Chen [US]; VincentDarmohusodo [US];MarketaLebl-Rinnova [US]; Chad Priest [US]; CatherineTachdjian [US]; P. Patron [US]; Ming Qi [CN]; L.Adamski-Werner [US]; Xiao-Qing Tang [US];Qing Chen [US]; VincentDarmohusodo [US]; MarketaLebl-Rinnova [US]; Chad Priest [US]

Publicationdate: 2006-03-02 | Patent publication No.: US-20060045953-A1|Assignees: Catherine Tachdjian [US]; P. Patron [US]; Ming Qi [CN]; L. Adamski-Werner[US]; Xiao-Qing Tang [US]; Qing Chen [US]; Vincent Darmohusodo [US]; MarketaLebl-Rinnova [US]; Chad Priest [US] |IPC: A23L1/22 | Oldestpriority date: 2005-02-04 | Publication date: 2006-03-02

Score: 7.874651 | Text size: 448058 | Find: similardocuments

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia Pa., ChemDiv of San Diego Calif., Chembridge ofSan Diego Calif.

ANTIVIRAL METHODS AND COMPOSITIONS

COEN, Donald, M[US];LOREGIAN,Arianna [US]; COEN, Donald, M[US];LOREGIAN,Arianna [US]

Publicationdate: 2006-02-23 | Patent publication No.: WO-2006019955-A2|Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: A61K31/473;A61K31/075; A61K31/4745; A61K31/175; A61K31/122; A61K31/53; C07D221/18;C07C205/34; C07D471/04; C07C337/08; C07C225/34; C07D487/04; A61P31/22 | Oldest priority date: 2004-07-14 | Publication date: 2006-02-23

Score: 15.290299 | Text size: 155061 | Find: similardocuments

screen thePeakdale (2,816 compounds), Bionet (4,800 compounds), Maybridge (8,800compounds), andChemDiv (28,864 compounds) libraries, and 4,348compounds out of the 50,000 of the Chembridge Microformat ... high throughputscreening, small molecules (5 mg/ml in DMSO) of the Maybridge, Bionet,Peakdale, ChemDiv, and Chembridge Microformat libraries wereobtained from the ICCB, and 100 nl of each compound were

Anti-viral therapeutics

Peter Distefano[US];D. Watson [US]; Rory Curtis [US]; J. Geesaman [US]; Edward Cannon[US];A. Navia [US]; Peter Distefano[US];D. Watson [US]; Rory Curtis [US]; J. Geesaman [US]; Edward Cannon[US];A. Navia [US]

Score: 11.918776 | Text size: 153251 | Find: similar documents

be purchasedcommercially, for example from Asinex, Moscow, Russia; Bionet, Camelford,England; ChemDiv, San Diego, Calif.

Use of stem cells to generate inner ear cells

Huawei Li [CN]; Albert Edge [US]; Stefan Heller[US];Huawei Li [CN]; Albert Edge [US]; Stefan Heller[US]

Score: 12.290053 | Text size: 131129 | Find: similardocuments

availablecompound libraries (suppliers include ChemBridge Corp (San Diego, Calif.)and ChemDiv (San Diego, Calif.)).

COMPOUNDS HAVING ACTIVITY IN INCREASING ION TRANSPORT BY MUTANT-CFTR ANDUSES THEREOF

VERKMAN, Alan[US];GUY, R. Kiplin[US];PEDEMONTE,Nicoletta [US]; GALIETTA, LuisJ.V. [US];VERKMAN, Alan[US];GUY, R. Kiplin[US];PEDEMONTE,Nicoletta [US]; GALIETTA, LuisJ.V. [US]

Score: 11.918776 | Text size: 154337 | Find: similardocuments

Foroptimization, compounds identified in the primary screen were purchasedfrom ChemDiv (out of -600,000 available compounds). Compoundswere prepared as 10 mM stock solutions in DMSO.

CANCER TREATMENT METHOD BY INHIBITING MAGE GENE EXPRESSION OR FUNCTION

LONGLEY, B.,Jack [US];YANG, Bing [US]; LONGLEY, B.,Jack [US];YANG, Bing [US]

Score: 16.750965 | Text size: 90618 | Find: similardocuments

Finally, twohighly complex libraries, the Chembridge and ChemDiv Librariesare screened. ... to cover the broadest part of biologically relevantpharmacophore diversity space. [00123] ChemDiv Library: Thislibrary is a 20,000 member compound library from Chemical Diversity Labs, inc.

Novel sequences encoding hepatitis C virus glycoproteins

Julie Dumonceaux[FR];G. Cormier [US]; P. Gardner [US]; Tatjana Dragic[US];Julie Dumonceaux[FR];G. Cormier [US]; P. Gardner [US]; Tatjana Dragic[US]

Publicationdate: 2005-12-01 | Patent publication No.: US-20050266400-A1|Assignees: Julie Dumonceaux [FR]; G. Cormier [US]; P. Gardner [US]; Tatjana Dragic[US] |IPC: C07H21/02 | Oldestpriority date: 2003-11-12 | Publication date: 2005-12-01

Score: 15.290299 | Text size: 185773 | Find: similardocuments

Forexample, ChemDiv (San Diego, Calif. ... ChemDiv hasa large number of small molecules that are usable as building blocks foridentifying and

METABOLIC KINASE MODULATORS ANDMETHODS OF USE AS PESTICIDES

MCMILLAN, Kirk[US];MCMILLAN, Kirk[US]

Score: 14.039395 | Text size: 77609 | Find: similardocuments

remainingentries are available from ChemBridge Research Laboratories 16981 Via Tazon,Suite K andChemDiv, Inc. 11558 Sorrento Valley Road, Suite 5 SanDiego, CA 92121 USA.

Methods of treating a disorder

Andrew Napper[US];Peter Distefano[US];A. Curtis [US]; Jeffrey Hixon[US];Thomas McDonagh[US];Julie Huber [US]; M. Solomon [US]; J. Thomas [IT]; Jean-FrancoisPons [GB];Andrew Napper[US];Peter Distefano[US];A. Curtis [US]; Jeffrey Hixon[US];Thomas McDonagh[US];Julie Huber [US]; M. Solomon [US]; J. Thomas [IT]; Jean-FrancoisPons [GB]

Publicationdate: 2005-09-22 | Patent publication No.: US-20050209300-A1|Assignees: Andrew Napper [US]; Peter Distefano [US]; A. Curtis [US]; Jeffrey Hixon[US]; Thomas McDonagh [US]; Julie Huber [US]; M. Solomon [US]; J. Thomas [IT];Jean-Francois Pons [GB] | IPC:A61K31/403 | Oldest priority date: 2003-09-12 | Publication date: 2005-09-22

Score: 11.569273 | Text size: 178682 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet, Camelford,England; ChemDiv, SanDiego, Calif.

FUNCTIONAL METHOD FOR GENERATING OR SCREENING FOR LIGANDS WHICH MODULATESTEROID HORMONE RECEPTORS

BARLETTA, Frank[US];O'DONNELL, Greg [US]; CHESKIS, Boris,J. [US];BARLETTA, Frank[US];O'DONNELL, Greg [US]; CHESKIS, Boris,J. [US]

Score: 17.377876 | Text size: 116846 | Find: similardocuments

ResearchBiochemicals; Cetek Coφoration;Charybdis Technologies, Inc.; ChemBridge Coφoration; ChemDiv, Inc.;ChemGenics Pharmaceuticals Inc.; ChemOvation Ltd.; ChemStar, Ltd.; Chrysalon;ComGenex, Inc. ... compounds); Maybridge 2 (704 compounds); Peakdale 1 (2,816compounds); Peakdale 2 (352 compounds);ChemDiv Combilab andInternational (28,864 compounds); Mixed Commercial Plate 1 (352 compounds);Mixed ... ActiMol; Aral Biosynthetics; ASDI Biosciences; Biotechnology Coφoration ofAmerica; Chembridge;ChemDiv; Florida Center - Heterocyclic Compounds;Microsource /MSDI; NorthStar; Peakdale; Texas Retaining

Functional method for generating or screening for ligands which modulatesteroid hormone receptors

Frank Barletta[US];Greg O'Donnell[US];J. Cheskis [US]; Frank Barletta[US];Greg O'Donnell[US];J. Cheskis [US]

Score: 17.377876 | Text size: 115948 | Find: similardocuments

ResearchBiochemicals; Cetek Corporation; Charybdis Technologies, Inc.; ChemBridgeCorporation; ChemDiv, Inc.; ChemGenics Pharmaceuticals Inc.;ChemOvation Ltd.; ChemStar, Ltd.; Chrysalon; ComGenex, Inc. ... compounds);Maybridge 2 (704 compounds); Peakdale 1 (2,816 compounds); Peakdale 2 (352compounds);ChemDiv Combilab and International (28,864 compounds);Mixed Commercial Plate 1 (352 compounds); Mixed ... ActiMol; AralBiosynthetics; ASDI Biosciences; Biotechnology Corporation of America;Chembridge;ChemDiv; Florida Center—Heterocyclic Compounds;Microsource/MSDI; NorthStar; Peakdale; Texas Retaining

Methods and compositions for CPG15-2

Elly Nedivi [US]; Tadahiro Fujino[US];Elly Nedivi [US]; Tadahiro Fujino[US]

Score: 11.918776 | Text size: 181001 | Find: similardocuments

availablefrom, for example, Nanoscale Combinatorial Synthesis Inc., Mountain View,Calif., ChemDiv Inc., San Diego, Calif., Pharmacopeia Drug Discovery,Princeton, N.J., and ArQule Inc., Medford, Mass.

ANTI-VIRAL THERAPEUTICS

DISTEFANO, Peter[US];WATSON, Alan, D.[US];CANNON, Edward,L. [US];NAVIA, Manuel,A. [US];CURTIS, Rory[US];GEESAMAN, Bard,J. [US];DISTEFANO, Peter[US];WATSON, Alan, D.[US];CANNON, Edward,L. [US];NAVIA, Manuel,A. [US];CURTIS, Rory[US];GEESAMAN, Bard,J. [US]

Publicationdate: 2005-08-11 | Patent publication No.: WO-2005072412-A2|Assignees: ELIXIR PHARMACEUTICALS, INC. [US] | IPC:A61K31/517; A61K31/54; A61K31/41; A61K31/415; A61K31/40; A61K31/38;A61K31/34 | Oldestpriority date: 2004-01-29 | Publication date:2005-08-11

Score: 12.290053 | Text size: 148806 | Find: similardocuments

be purchasedcommercially, for example from Asinex, Moscow, Russia; Bionet, Camelford,England; ChemDiv, SanDiego, CA; Comgenex, Budapest, Hungary;Enamine, Kiev, Ukraine; IF Lab, Ukraine;

Novel leukotriene, B4 receptor

MasazumiKamohara [JP]; MitsuyukiMatsumoto [JP]; Jun Takasaki[JP];Tetsu Saito [JP]; Takahide Ohishi[JP];MasazumiKamohara [JP]; MitsuyukiMatsumoto [JP]; Jun Takasaki[JP];Tetsu Saito [JP]; Takahide Ohishi[JP]

Score: 13.793969 | Text size: 84963 | Find: similardocuments

arecommercially available reagents, and compound A is on the market as a codenumber 0199-0032 ofChemDiv, Inc, and compound B as a code number TPB-488of InterBioScreen.

Medicaments

John Alberti[US];Stephen Garland[GB];Kendall Jung[US];Marvin Veal [US]; JasonWitherington [GB]; John Alberti[US];Stephen Garland[GB];Kendall Jung[US];Marvin Veal [US]; JasonWitherington [GB]

Publicationdate: 2005-07-14 | Patent publication No.: US-20050153978-A1|Assignees: John Alberti [US]; Stephen Garland [GB]; Kendall Jung [US]; Marvin Veal[US]; Jason Witherington [GB] | IPC: C07D43/14 | Oldestpriority date: 2002-03-22 | Publication date: 2005-07-14

Score: 13.556976 | Text size: 85760 | Find: similardocuments

16981 ViaTazon, Suite G, San Diego CA 92127 USA 47 4-(1H-benzoimidazol-2-yl)furazan-3-ylamine ChemDiv Inc., P.O. Box90639, San Diego CA 92169 USA EXAMPLE 48

METHODS OF TREATING A DISORDER

NAPPER, Andrew[US];DISTEFANO, Peter[US];HIXON, Jeffrey[US];MCDONAGH, Thomas[US];CURTIS, Rory[US];NAPPER, Andrew[US];DISTEFANO, Peter[US];HIXON, Jeffrey[US];MCDONAGH, Thomas[US];CURTIS, Rory[US]

Score: 10.928354 | Text size: 207466 | Find: similardocuments

be purchasedcommercially, for example from Asinex, Moscow, Russia; Bionet, Camelford,England; ChemDiv, SanDiego CA; Comgenex, Budapest, Hungary;Enamine, Kiev, Ukraine; IF Lab, Ukraine; Interbioscreen,

Oxytocin inhibitors

Duncan RobertArmour [GB];Andrew SimonBell [GB];Paul JohnEdwards [GB]; David Ellis [GB]; David Hepworth[GB];Mark LlewellynLewis [GB];ChristopherRonald Smith [GB]; Duncan RobertArmour [GB];Andrew SimonBell [GB];Paul JohnEdwards [GB]; David Ellis [GB]; David Hepworth[GB];Mark LlewellynLewis [GB];ChristopherRonald Smith [GB]

Score: 13.10661 | Text size: 123627 | Find: similardocuments

[[image:EMI-C00178]][[image:EMI-C00179]] 1.23 a=2-(2-fluorophenoxy)ethylamine was obtained fromChemDivInc. Building Blocks b=2-(1H-pyrazol-1-yl)ethylamine was obtainedfrom Peakdale EXAMPLES 63 TO 218 The

Methods for identifying small molecules that bind specific rna structuralmotifs

Morgan Conn [US]; MatthewPelligrini [US]; Seongwoo Hwang[US];Young-Choon Moon[US];Neil Almstead[US];Morgan Conn [US]; MatthewPelligrini [US]; Seongwoo Hwang[US];Young-Choon Moon[US];Neil Almstead[US]

Publicationdate: 2005-06-30 | Patent publication No.: US-20050142545-A1|Assignees: Morgan Conn [US]; Matthew Pelligrini [US]; Seongwoo Hwang [US]; Young-ChoonMoon [US]; Neil Almstead [US] | IPC: C12Q1/68 | Oldestpriority date: 2001-04-11 | Publication date:2005-06-30

Score: 12.484504 | Text size: 219261 | Find: similardocuments

Compounds and methods for modulating functions of classical cadherins

W. Blaschuk [CA]; D. Michaud [CA]; W. Blaschuk [CA]; D. Michaud [CA]

Score: 13.4640045 | Text size: 276124 | Find: similardocuments

from a database(e.g., Cambridge Crystallographic Database, Maybridge Structural Database,and ChemDivDatabase). ... The other database used in thestructure-based screen, ChemDiv (CDC) database, includes298,440 compounds, 175,316 compounds from the international diversity

NOVEL SEQUENCES ENCODING HAPATITIS C VIRUS GLYCOPROTEINS

CORMIER,Emmanuel, G. [US]; GARDNER, Jason[US];DRAGIC, Tatjana[US];DUMONCEAUX,Julie [FR]

Publicationdate: 2005-05-26 | Patent publication No.: WO-2005047481-A2|Assignees: PROGENICS PHARMACEUTICALS, INC. [US]; ALBERT EINSTEIN COLLEGE OF MEDICINEOF YESHIVA UNIVERSITY [US] | IPC: C07H21/04; C12N7/00; C12N7/01; C12Q1/70 | Oldest priority date:2003-11-12 | Publication date: 2005-05-26

Score: 14.719831 | Text size: 224757 | Find: similardocuments

Forexample, ChemDiv (San Diego, CA) has an InternationalDiversity collection of small molecules comprising over ... ChemDiv hasa large number of small molecules that are usable as building blocks foridentifying and

NOVEL FLAVORS, FLAVOR MODIFIERS, TASTANTS, TASTE ENHANCERS, UMAMI ORSWEET TASTANTS, AND/OR ENHANCERS AND USE THEREOF

TACHDJIAN,Catherine [US]; PATRON, Andrew,P. [US];ADAMSKI-WERNER,Sara, L. [US]; BAKIR, Farid[US];CHEN, Qing [US]; DARMOHUSODO,Vincent [US]; HOBSON, Stephen,Terrence [US]; LI, Xiadong [US]; QI, Ming [CN]; ROGERS, Daniel,Harry [US];RINNOVA, Marketa[US];SERVANT, Guy[US];TANG, Xiao-Qing[US];ZOLLER, Mark[US];WALLACE, Mark[US];XING, Amy [US]; GUBERNATOR,Klaus [US]

Score: 8.557886 | Text size: 387815 | Find: similardocuments

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia PA, ChemDiv of San Diego CA, Chembridge of SanDiego CA, Asinex of Moscow Russia, SPECS/BIOSPECS of the

Novel flavors, flavor modifiers, tastants, taste enhancers, umami orsweet tastants, and/or enhancers and use thereof

CatherineTachdjian [US]; P. Patron [US]; L.Adamski-Werner [US]; Farid Bakir [US]; Qing Chen [US]; VincentDarmohusodo [US]; Terrence Hobson[US];Xiaodong Li [US]; Ming Qi [CN]; Harry Rogers[AU];Marketa Rinnova[US];Guy Servant [US]; Xiao-Qing Tang[US];Mark Zoller [US];David Wallace[US];Amy Xing [US]; Klaus Gubernator[US];CatherineTachdjian [US]; P. Patron [US]; L.Adamski-Werner [US]; Farid Bakir [US];Qing Chen [US]; VincentDarmohusodo [US]; Terrence Hobson[US];Xiaodong Li [US]; Ming Qi [CN]; Harry Rogers[AU];Marketa Rinnova[US];Guy Servant [US]; Xiao-Qing Tang[US];Mark Zoller [US]; David Wallace[US];Amy Xing [US]; Klaus Gubernator[US]

Publicationdate: 2005-04-21 | Patent publication No.: US-20050084506-A1|Assignees: Catherine Tachdjian [US]; P. Patron [US]; L. Adamski-Werner [US]; FaridBakir [US]; Qing Chen [US]; Vincent Darmohusodo [US]; Terrence Hobson [US];Xiaodong Li [US]; Ming Qi [CN]; Harry Rogers [AU]; Marketa Rinnova [US]; GuyServant [US]; Xiao-Qing Tang [US]; Mark Zoller [US]; David Wallace [US]; AmyXing [US]; Klaus Gubernator [US] | IPC: A61K47/00 | Oldestpriority date: 2003-08-06 | Publication date: 2005-04-21

Score: 8.202065 | Text size: 411358 | Find: similar documents

offices, andother well know suppliers such as Fisher Scientific, TCI America ofPhiladelphia Pa., ChemDiv of San Diego Calif., Chembridge ofSan Diego Calif.

HEDGEHOG PATHWAY ANTAGONISTS

BEACHY, Philip,A. [US];CHEN, James, K.[US];TAIPALE, Anssi,J. [US];BEACHY, Philip,A. [US];CHEN, James, K.[US];TAIPALE, Anssi,J. [US]

Publicationdate: 2005-04-14 | Patent publication No.: WO-2005033288-A2|Assignees: THE JOHNS HOPKINS UNIVERSITY [US] | IPC:A61K31/385; A61K31/425; A61K31/44; C07D211/70; C07D239/00; C07D311/80;C07D311/82; C07D417/00 | Oldestpriority date: 2003-09-29 |Publicationdate: 2005-04-14

Score: 11.918776 | Text size: 163075 | Find: similardocuments

the testagent. [0262] In an exemplary embodiment, a library of candidate compoundsobtained fromChemDiv, Inc. (San Diego, CA) was screened for Hhpathway modulators utilizing a scheme adapted to the techniques

Methods of inhibiting osteoclast activity

I. Greene [US]; RamachandranMurali [US];MasahikoKinosaki [JP]; I. Greene [US]; RamachandranMurali [US];MasahikoKinosaki [JP]

Score: 19.22352 | Text size: 82660 | Find: similardocuments

WNT PATHWAY ANTAGONISTS

BEACHY, Philip,A. [US];CHEN, James, K.[US];MANN, Randall,K. [US];BEACHY, Philip,A. [US];CHEN, James, K.[US];MANN, Randall,K. [US]

Score: 12.290053 | Text size: 137243 | Find: similardocuments

format and,using pin transfers on Biomek FX robotics (Beckman), we screened 40,000compounds fromChemDiv and ChemBridge collections (at a concentrationof approx.

METHODS AND COMPOSITIONS FOR CPG15-2

NEDIVI, Elly[US];FUJINO, Tadahiro[US];NEDIVI, Elly[US];FUJINO, Tadahiro[US]

Score: 11.569273 | Text size: 194311 | Find: similardocuments

availablefrom, for example, Nanoscale Combinatorial Synthesis Inc., Mountain View,CA, ChemDiv Inc., San Diego, CA, Pharmacopeia Dmg Discovery,Princeton, NJ, and ArQule Inc., Medford, MA.

METHODS OF TREATING A DISORDER

NAPPER, Andrew[US];DISTEFANO, Peter[US];HIXON, Jeffrey[US];MCDONAGH, Thomas[US];SOLOMON,Jonathan, M. [US]; HUBER, L. Julie[US];CURTIS, Rory[US];NAPPER, Andrew[US];DISTEFANO, Peter[US];HIXON, Jeffrey[US];MCDONAGH, Thomas[US];SOLOMON,Jonathan, M. [US]; HUBER, L. Julie[US];CURTIS, Rory[US]

Score: 11.918776 | Text size: 175310 | Find: similardocuments

can beobtained from commercial sources (e.g., Asinex, Moscow, Russia; Bionet,Camelford, England; ChemDiv, SanDiego, CA; Comgenex, Budapest,Hungary; Enamine, Kiev, Ukraine; IF Lab,

Tetrahydroquinoline derivatives

Corine Renee VanStraten [NZ]; Gijsbertus VanSomeren [NL]; Jurgen Schulz[GB]

Publicationdate: 2004-11-25 | Patent publication No.: US-20040236109-A1|IPC: C07D215/36; C07D215/60 | Oldestpriority date: 2001-07-02 | Publication date: 2004-11-25

Score: 13.327991 | Text size: 111738 | Find: similardocuments

Collection,order nrs 28020-A0839/0039328 (CAS 310456-97-4) and -A0705/0032919 (CAS327981-38-4);ChemDiv.

Cystic fibrosis transmembrane conductance regulator protein inhibitorsand uses thereof

Alan Verkman[US];Tonghui Ma [US]

Publicationdate: 2004-11-25 | Patent publication No.: US-20040235800-A1|IPC: A61K31/655; A61K31/426 | Oldestpriority date: 2003-09-30 | Publication date: 2004-11-25

Score: 11.918776 | Text size: 145843 | Find: similardocuments

Structure-activityanalysis was done on analogs purchased from ChemBridge and ChemDiv (SanDiego, Calif.

DRUG DISCOVERY METHOD AND APPARATUS

CHEN, Hao [US]; MANYAK, David,M. [US];CARLSON, Peter,S. [US];WANG, Fong, Liu[US];LIU, Ming [US]

Score: 12.484504 | Text size: 158480 | Find: similardocuments

librarieswere processed using above described in silico screening methods, namely,ASINEX, ChemDiv, Enamine, ComGenex, Would Molecule(MDD), MayBridge,RCL, hnation, IBX, SPECS, WSB.

HIV INTEGRASE INHIBITORS

VERSCHUEREN,Wim, Gaston [BE]; DIERYNCK, Inge[BE];SURLERAUX,Dominique, Louis, Nestor, Ghislain [BE]; DAEYAERT,Frederik, Frans, Desiré [BE]; VERSCHUEREN,Wim, Gaston [BE]; DIERYNCK, Inge[BE];SURLERAUX,Dominique, Louis, Nestor, Ghislain [BE]; DAEYAERT,Frederik, Frans, Desiré [BE]

Score: 11.918776 | Text size: 198992 | Find: similardocuments

lH-l,2,3-Triazole-4,5-dicarboxylicacid, dimethyl is commercially available from ChemDiv, Inc. ProductLibrary.

Methods for identifying small molecules that bind specific rna structuralmotifs

F. Rando [US]; Eleln Welch [US]

Publicationdate: 2004-11-04 | Patent publication No.: US-20040219545-A1|IPC: C12Q1/68 | Oldestpriority date: 2004-02-03 |Publicationdate: 2004-11-04

Score: 11.918776 | Text size: 256139 | Find: similardocuments

METHOD FOR IDENTIFYING MODULATORS OF G PROTEIN COUPLED RECEPTOR SIGNALING

GILCHRIST,Annette [US]; HAMM, Heidi, M.[US];GILCHRIST,Annette [US]; HAMM, Heidi, M.[US]

Score: 17.040009 | Text size: 252368 | Find: similardocuments

smallmolecules, such as β-turnmimetic libraries and the like, may be purchased from for example ChemDiv(http://www.chemdiv.com),Pharmacopia (http://www.pcop.com or Combichem (http://www.combichemlab. ... Forexample, ChemDiv uses more than 800 individual chemical cores,a unique Building Block Library, and proprietary ... In addition, ChemDiv'scompounds are designed to ensure their similarity to drugs adjusted accordingto proprietary ... were employed to screen a small molecule library (a 10,000compound library representative of ChemDiv' s Diverse Collection ofdrug-like molecules) for compounds that bind activated rhodopsin and

Oxa(thia)zolidine compounds, process for preparation thereof andanti-inflammatory agents

Masae Takagi[JP];Tadayuki Nishibe[JP];KeiichiIshimitsu [JP]

Publicationdate: 2004-09-23 | Patent publication No.: US-20040186096-A1|IPC: A61K31/55; A61K31/454; A61K31/421; A61K31/426 |Oldest priority date: 2001-06-25 | Publicationdate: 2004-09-23

Score: 14.039395 | Text size: 78413 | Find: similardocuments

by thefollowing chemical formula are disclosed in the catalogue for manufacturedgoods dealt by ChemDiv, Inc. or ChemStar, Ltd.

Methods and compositions for soluble CPG15

Elly Nedivi [US]; Ulrich Putz [US]

Publicationdate: 2004-09-09 | Patent publication No.: US-20040176291-A1|IPC: A61K38/17 | Oldestpriority date: 2003-09-24 |Publicationdate: 2004-09-09

Score: 12.290053 | Text size: 147124 | Find: similardocuments

Compounds and methods for modulating functions of nonclassical cadherins

W. Blaschuk [CA]; D. Michaud [CA]

Score: 9.838301 | Text size: 338277 | Find: similardocuments

from adatabase (e.g., Cambridge Crystallographic Database, Maybridge StructuralDatabase, and ChemDivDatabase).

PHARMACEUTICAL COMPOSITIONS COMPRISING THIENO[2,3-C]PYRIDINE DERIVATIVESAND USE THEREOF

GREGOR, Paul[IL];HARRIS, Nicholas[IL];KOPPEL, Juraj[SK];ZHUK, Regina[IL];GREGOR, Paul[IL];HARRIS, Nicholas[IL];KOPPEL, Juraj[SK];ZHUK, Regina[IL]

Score: 12.290053 | Text size: 147711 | Find: similardocuments

Compoundswere synthesized or purchased from ChemDiv Labs (San Diego,CA), dissolved in DMSO, diluted in PBS and added to the wells at various

Method for screening compounds using consensus selection

M. Van Rhee [US]

Score: 15.115125 | Text size: 70635 | Find: similardocuments

compoundstargeted, 14,431 compounds obtained from then available stock of the followingvendors:ChemDiv Inc, San Diego, Calif, Tripos Inc., St. Louis, Mo.,ChemBridge Inc., San Diego, Calif., and AsInEx Inc.

METHODS AND SYSTEMS FOR THE IDENTIFICATION OF RNA REGULATORY SEQUENCESAND COMPOUNDS THAT MODULATE THEIR FUNCTION

PELLEGRINI,Matthew, C. [US]; TROTTA,Christopher, R. [US]; HUQ, Shah, I.[US]

Score: 13.793969 | Text size: 109336 | Find: similardocuments

division ofKey Organics Limited), Camelford, UK; ChemBridge Corporation, San Diego,California; ChemDiv hie, San Diego, California; ChemRxAdvanced Technologies, South San Francisco, California; ComGenex

METHOD FOR SCREENING COMPOUNDS USING CONSENSUS SELECTION

VAN RHEE,Albert, Michiel [US]; VAN RHEE,Albert, Michiel [US]

Score: 15.115125 | Text size: 72111 | Find: similardocuments

compoundstargeted, 14,431 compounds obtained from then available stock of the followingvendors:ChemDiv hie, San Diego, CA, Tripos Inc., St. Louis, MO,ChemBridge Inc., San Diego, CA, and AsInEx Inc.

Compositions and methods for inhibiting platelet activation andthrombosis

CharlesFlaumenhaft [US]

Score: 14.719831 | Text size: 188605 | Find: similardocuments

from thecompound 3-(acetyloxy)-4,4,4-trichloro-1-(2,4-dichlorophenyl)-1-butanone,available from ChemDiv, Inc. (San Diego, Calif.), ContactService Co. ... Synthesis, Inc., Enamine, AsInEx, Aldrich Chemical Company,Inc. (Milwaukee, Wis.), and ChemDiv, Inc. Compounds having Hor NO2 at R1 and/or H, alkyl, aralkyl, alkenyl, cycloalkyl, cycloalkenyl and

METHODS OF SCREENING FOR ANTI-INFLAMMATORY DRUGS AND USE THEREOF

GREGOR, Paul[IL];HARRIS, Nicholas[IL];KOPPEL, Juraj[SK];GREGOR, Paul[IL];HARRIS, Nicholas[IL];KOPPEL, Juraj[SK]

Score: 12.685205 | Text size: 116916 | Find: similardocuments

A diversecollection of small molecule compounds was purchased from ChemDiv Inc. (SanDiego, CA). Compounds were dissolved in DMSO at 10 mM and further diluted priorto assay.

Drug discovery method and apparatus

Hao Chen [US]; M. Manyak [US]; S. Carlson [US]; Liu Wang [US]; Ming Liu [US]

Publicationdate: 2004-06-17 | Patent publication No.: US-20040117125-A1|IPC: G06F19/00; G01N33/48; G01N33/50; G01N31/00 |Oldest priority date: 2003-09-25 | Publicationdate: 2004-06-17

Score: 12.484504 | Text size: 163083 | Find: similardocuments

librarieswere processed using above described in silico screening methods, namely,ASINEX, ChemDiv, Enamine, ComGenex, Would Molecule(MDD), MayBridge,RCL, Imation, IBX, SPECS, WSB.

COMPOUNDS AND METHODS FOR MODULATING DESMOSOMAL AND ATYPICALCADHERIN-MEDIATED CELL ADHESION

BLASCHUK, Orest,W. [CA];MICHAUD,Stephanie, D. [CA]; BLASCHUK, Orest,W. [CA];MICHAUD,Stephanie, D. [CA]

Publicationdate: 2004-06-10 | Patent publication No.: WO-2004048411-A2|Assignees: ADHEREX TECHNOLOGIES, INC. [CA] | IPC:A61K9/00;A61K9/70; A61K38/00; C07K14/705; C07K16/28; G01N33/50; G01N33/68 | Oldest priority date: 2002-11-14 | Publication date:2004-06-10

Score: 9.838301 | Text size: 334215 | Find: similardocuments

from adatabase (e.g., Cambridge Crystallographic Database, Maybridge StructuralDatabase, and ChemDivDatabase).

COMPOUNDS AND METHODS FOR MODULATING FUNCTIONS OF CLASSICAL CADHERINS

BLASCHUK, Orest,W. [CA];MICHAUD,Stephanie, Denise [CA]; BLASCHUK, Orest,W. [CA];MICHAUD,Stephanie, Denise [CA]

Publicationdate: 2004-05-27 | Patent publication No.: WO-2004044000-A2|Assignees: ADHEREX TECHNOLOGIES, INC. [CA] | IPC:A61K38/00;C07D211/58; C07K5/103; C07K5/113; C07K5/117; C07K14/705 | Oldest priority date: 2002-11-14 | Publication date: 2004-05-27

Score: 13.697729 | Text size: 277232 | Find: similardocuments

Compounds regulating cell proliferation and differentiation

Philip Leder[US];R. Fantin [US]

Publicationdate: 2004-05-20 | Patent publication No.: US-20040097408-A1|IPC: A61K38/00 | Oldestpriority date: 2003-07-03 |Publicationdate: 2004-05-20

Score: 11.239684 | Text size: 188477 | Find: similardocuments

F16 is2S-13965); Asinex Ltd., Moscow, Russia (the catalogue number for F16 is BAS1027104); and ChemDiv, Inc., U.S. QR is available fromAldrich-Sigma, under catalog no. 20,131-6.

REPAIRING OR REPLACING TISSUES OR ORGANS

JAIN, Rakesh, K.[US];FUKUMURA, Dai[US];JAIN, Rakesh, K.[US];FUKUMURA, Dai[US]

Score: 11.569273 | Text size: 149791 | Find: similardocuments

arecommercially available from Nanoscale Combinatorial Synthesis Inc., Mountain View,CA, ChemDiv Inc., San Diego, CA, Pharmacopeia Drug Discovery,Princeton, NJ, and ArQule Inc., Medford, MA.

3,4-DIARYLPYRAZOLES AND THEIR USEIN THE THERAPY OF CANCER

DRYSDALE,Martin, James [GB]; DYMOCK, Brian,William [GB]; BARRIL-ALONSO,Xavier [GB];WORKMAN, Paul[GB];PEARL, Laurence,Harris [GB];PRODROMOU,Chrisostomos [GB]; MACDONALD,Edward [GB];DRYSDALE,Martin, James [GB]; DYMOCK, Brian,William [GB]; BARRIL-ALONSO,Xavier [GB];WORKMAN, Paul[GB];PEARL, Laurence,Harris [GB];PRODROMOU,Chrisostomos [GB]; MACDONALD,Edward [GB]

Publication date: 2003-07-10 | Patentpublication No.: WO-2003055860-A1|Assignees: VERNALIS (CAMBRIDGE) LIMITED [GB]; CANCER RESEARCH TECHNOLOGY LTD. [GB];THE INSTITUTE OF CANCER RESEARCH [GB] | IPC: A61K31/415;C07D231/12; C07D231/14; C07D231/16; C07D401/04; C07D401/10; C07D403/04;C07D405/04; C07D405/12; C07D405/14; C07D409/04; C07D417/04 | Oldest priority date: 2001-12-21 | Publication date: 2003-07-10

Score: 9.838301 | Text size: 357486 | Find: similardocuments

examples ofcompounds of the present invention were obtained from commercial sources(e.g., ChemDiv Inc., San Diego, California, USA).

MULTI-PARAMETER HIGH THROUGHPUT SCREENING ASSAYS (MPHTS)

ALTAR, Anthony,C. [US];BROCKMAN,Jeffrey, A. [US]; EVANS, David[US];HOOK, Derek [US]; KLIMCZAK, Leszek[US];LAENG, Pascal[US];PALFREYMAN,Michael [US]; RAJAN, Prithi[US];ALTAR, Anthony,C. [US];BROCKMAN,Jeffrey, A. [US]; EVANS, David[US];HOOK, Derek [US];KLIMCZAK, Leszek[US];LAENG, Pascal[US];PALFREYMAN,Michael [US]; RAJAN, Prithi[US]

Score: 12.290053 | Text size: 195696 | Find: similardocuments

Louis MO),ChemBridge (ChemBridge Corp., San Diego CA), Chemdiv (ChemDiv Inc., SanDiego CA) and Prestwick (Prestwick Chemical, Inc. , Washington DC), to name afew.

Method for identifying inhibitors of G protein coupled receptor signaling

AnnetteGilchrist [US]; M. Hamm [US]

Publicationdate: 2003-05-22 | Patent publication No.: US-20030096297-A1|IPC: G01N33/53; G01N33/567; A61K31/00; C07K14/435; C07K14/705 | Oldest priority date: 2001-05-11 | Publication date: 2003-05-22

Score: 12.290053 | Text size: 170662 | Find: similardocuments

OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS)

BOMBRUN,Agnès [FR]; GERBER, Patrick[CH];CHURCH, Dennis[CH];BOMBRUN,Agnès [FR]; GERBER, Patrick[CH];CHURCH, Dennis[CH]

Publicationdate: 2003-05-08 | Patent publication No.: WO-2003037328-A1|Assignees: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. [NL] | IPC: A61K31/404;C07D209/38; C07D209/40; C07D211/62; C07D257/04; C07D295/096; C07D307/68;C07D317/60; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D409/14;C07D413/12; C07D417/14; C07D513/04 | Oldestpriority date: 2001-10-30 |Publicationdate: 2003-05-08

Score: 10.354719 | Text size: 284971 | Find: similardocuments

a), b), e),f) and g) are commercially available from catalogues of ChemDiv.

Novel leukotriene B4 receptor

MasazumiKamohara [JP]; MitsuyukiMatsumoto [JP]; Jun Takasaki[JP];Tetsu Saito [JP]; Takahide Ohishi[JP]

Publicationdate: 2003-04-24 | Patent publication No.: US-20030077709-A1|IPC: C07K14/715; C12P21/02; C12N5/06 | Oldestpriority date: 2000-03-21 | Publication date: 2003-04-24

Score: 13.556976 | Text size: 87208 | Find: similardocuments

arecommercially available reagents, and compound A is on the market as a codenumber 0199-0032 ofChemDiv, Inc, and compound B as a code number TPB-488of InterBioScreen.

Protein aggregation assays and uses thereof

Les Kondejewski[CA];AvijitChakrabartty [CA]; Xiao-Fei Qi [CA]; Neil Cashman[CA]

Publicationdate: 2003-01-30 | Patent publication No.: US-20030022243-A1|IPC: G01N33/53; G01N33/567 | Oldestpriority date: 2002-06-20 | Publication date: 2003-01-30

Score: 11.918776 | Text size: 154370 | Find: similardocuments

TETRAHYDROQUINOLINE DERIVATIVES

VAN STRATEN,Nicole, Corine, Renée [NL]; VAN SOMEREN,Rudolf, Gijsbertus [NL]; SCHULZ, Jurgen[GB];VAN STRATEN,Nicole, Corine, Renée [NL]; VAN SOMEREN,Rudolf, Gijsbertus [NL]; SCHULZ, Jurgen[GB]

Publicationdate: 2003-01-16 | Patent publication No.: WO-2003004028-A1|Assignees: AKZO NOBEL N.V. [NL] | IPC: A61K31/47; A61K31/4709; C07D215/08; C07D215/20; C07D215/38; C07D215/48 | Oldest priority date: 2001-07-02 | Publication date: 2003-01-16

Score: 13.327991 | Text size: 117862 | Find: similardocuments

order nrs28020-A0839/0039328 (CAS 310456-97-4) and -A0705/0032919 (CAS 327981-38- 04); ChemDiv.

COMPOSITIONS AND METHODS FOR INHIBITING PLATELET ACTIVATION ANDTHROMBOSIS

FLAUMENHAFT,Robert, Charles [US]; FLAUMENHAFT,Robert, Charles [US]

Publicationdate: 2003-01-09 | Patent publication No.: WO-2003001968-A2|Assignees: BETH ISRAEL DEACONESS MEDICAL CENTER [US] |IPC: A61K31/215; A61K31/41; A61K31/435; A61K31/473; A61K31/495; A61K31/54;A61K45/06; C12Q1/48; C12Q1/56 | Oldestpriority date:2001-06-26 | Publication date: 2003-01-09

Score: 14.719831 | Text size: 175566 | Find: similardocuments

from thecompound 3-(acetyloxy)- 4,4,4-trichloro-l-(2,4-dichlorophenyl)-l-butanone,available from ChemDiv, Inc. (San Diego, CA), Contact ServiceCo. ... Synthesis, Inc., Enamine, AsInEx, Aldrich Chemical Company, Inc.(Milwaukee, WI), and ChemDiv, Inc. Compounds having H or NO2at Ri and/or H, alkyl, aralkyl, alkenyl, cycloalkyl, cycloalkenyl and

PROTEIN AGGREGATION ASSAYS AND USES THEREOF

KONDEJEWSKI, Les[CA];CHAKRABARTTY,Avijit [CA];QI, Xiao-Fei[CA];CASHMAN, Neil[CA];KONDEJEWSKI, Les[CA];CHAKRABARTTY,Avijit [CA];QI, Xiao-Fei[CA];CASHMAN, Neil[CA]

Score: 11.918776 | Text size: 153847 | Find: similardocuments

arecommercially available from Nanoscale Combinatorial Synthesis Inc., MountainView, CA, ChemDiv Inc., San Diego, CA, Pharmacopeia Drag Discovery,Princeton, NJ, and ArQule Inc., Medford, MA.

NOVEL LEUKOTRIENE B4 RECEPTOR

KAMOHARA,Masazumi, Yamanouchi Pharm. Co., Ltd [JP]; MATSUMOTO,Mitsuyuki [JP]; TAKASAKI, Jun[JP];SAITO, Tetsu[JP];OHISHI, Takahide[JP]

Publicationdate: 2003-01-02 | Patent publication No.: EP-1270589-A1|Assignees: YAMANOUCHI PHARMACEUTICAL CO., LTD. [JP] | IPC:C07K14/705; C12N15/12; C12N1/21; C12N1/19; C12N5/10; C12P21/02; C07K16/28;C12Q1/02; G01N33/50; G01N33/15 | Oldest prioritydate:2000-06-22 | Publicationdate: 2003-01-02

Score: 13.556976 | Text size: 86677 | Find: similardocuments

arecommercially available reagents, and compound A is on the market as a codenumber 0199-0032 ofChemDiv, Inc, and compound B as a code number TPB-488of InterBioScreen.

External link

HIGH THROUGHPUT CELL-BASED ASSAY FOR MONITORING SODIUM CHANNEL ACTIVITYAND DISCOVERY OF SALTY TASTE MODULATING COMPOUNDS

CALLAMARAS,Nicholas [US]; CHANG, Hong [US]; CALLAMARAS,Nicholas [US]; CHANG, Hong [US]

Score: 13.556976 | Text size: 119525 | Find: similardocuments

It will beappreciated that there are many suppliers of chemical compounds,including ChemDiv (San Diego, CA), Sigma-Aldrich (St.

METHODS FOR IDENTIFYING SMALL MOLECULES THAT BIND SPECIFIC RNA STRUCTURALMOTIFS

RANDO, Robert[US];WELCH, Ellen[US];RANDO, Robert[US];WELCH, Ellen[US]

Score: 11.918776 | Text size: 254320 | Find: similardocuments

division ofKey Organics Limited ), Camelford, UK; ChemBridge Corporation, San Diego,California; ChemDiv Inc, San Diego, California.

METHODS FOR IDENTIFYING SMALL MOLECULES THAT BIND SPECIFIC RNA STRUCTURALMOTIFS

ALMSTEAD, Neil,G. [US];ALMSTEAD, Neil,G. [US]

Score: 12.484504 | Text size: 223581 | Find: similardocuments

division ofKey Organics Limited ), Camelford, UK; ChemBridge Corporation, San Diego,California; ChemDiv Inc, San Diego, California.

METHOD FOR IDENTIFYING INHIBITORS OF G PROTEIN COUPLED RECEPTOR SIGNALING

GILCHRIST,Annette [US]; HAMM, Heidi, E.[US]

Score: 12.290053 | Text size: 166012 | Find: similardocuments

COMPOUNDS REGULATING CELL PROLIFERATION AND DIFFERENTIATION

LEDER, Philip[US];FANTIN, Valeria,R. [US];LEDER, Philip[US];FANTIN, Valeria,R. [US]

Publicationdate: 2002-08-08 | Patent publication No.: WO-2002060426-A2|Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US] | IPC: A61K31/00;A61K31/4184; A61K31/4422; A61K31/4439; A61K31/47; A61K31/498; A61K31/55 | Oldest priority date: 2001-01-03 |Publicationdate: 2002-08-08

Score: 11.239684 | Text size: 185281 | Find: similardocuments

F16 is2S-13965); Asinex Ltd., Moscow, Russia (the catalogue number for F16 is BAS1027104); and ChemDiv, Inc., U.S. QR is available fromAldrich-Sigma, under catalog no. 20,131-6.

CARBAZOLE DERIVATIVES AND THEIR USES AS HEPARANASE INHIBITORS

AYAL-HERSHKOVITZ,Maty [IL];MIRON, Daphna[IL];KOLLER, Avi [IL]; ILAN, Neta [IL]; LEVY, Ofra [IL]; AYAL-HERSHKOVITZ,Maty [IL];MIRON, Daphna[IL];KOLLER, Avi [IL]; ILAN, Neta [IL]; LEVY, Ofra [IL]

Publicationdate: 2002-08-08 | Patent publication No.: WO-2002060867-A2|Assignees: INSIGHT STRATEGY AND MARKETING LTD [IL] | IPC:A61K31/00; A61K31/18; A61K31/496; A61K31/517; C07D209/88; C07D403/12 | Oldest priority date: 2001-01-29 | Publication date: 2002-08-08

Score: 12.685205 | Text size: 117159 | Find: similardocuments

Compounds 1,2, 5, and 6 were purchased from ChemDiv, Chemical Diversity (SanDiego, CA, USA). Compound 4 was purchased from Tripos Inc. (St.

DIPHENYL ETHER DERIVATIVES AND THEIR USES AS HEPARANASE INHIBITORS

AYAL-HERSHKOVITZ,Maty [IL];MIRON, Daphna[IL];KOLLER, Avi [IL]; ILAN, Neta [IL]; LEVY, Ofra [IL]; AYAL-HERSHKOVITZ,Maty [IL];MIRON, Daphna[IL];KOLLER, Avi [IL]; ILAN, Neta [IL]; LEVY, Ofra [IL]

Score: 12.892465 | Text size: 107283 | Find: similardocuments

Compounds 1,3 and 4 were purchased from ChemDiv, Chemical Diversity (San Diego,CA, USA).

BENZ-1,3-AZOLE DERIVATIVES AND THEIR USES AS HEPARANASE INHIBITORS

AYAL-HERSHKOVITZ,Maty [IL];MIRON, Daphna[IL];LEVY, Ofra [IL]; AYAL-HERSHKOVITZ,Maty [IL];MIRON, Daphna[IL];LEVY, Ofra [IL]

Publicationdate: 2002-08-08 | Patent publication No.: WO-2002060374-A2|Assignees: INSIGHT STRATEGY AND MARKETING LTD [IL] | IPC:A61K31/4184; A61K31/428; A61K31/4709; C07D235/18; C07D277/28; C07D277/84;C07D401/14; C07D417/06 | Oldestpriority date: 2001-01-29 | Publication date: 2002-08-08

Score: 12.290053 | Text size: 156782 | Find: similardocuments

Compounds 8,9, 11, 14, 15, 16, and 17 of the invention were purchased from ChemDiv,Chemical Diversity (San-Diego, CA, USA).

INDOLE DERIVATIVES AND THEIR USES AS HEPARANASE INHIBITORS

AYAL-HERSHKOVITZ,Maty [IL];MIRON, Daphna[IL];LEVY, Ofra [IL]; AYAL-HERSHKOVITZ,Maty [IL];MIRON, Daphna[IL];LEVY, Ofra [IL]

Score: 12.685205 | Text size: 116246 | Find: similardocuments

Compounds 1,2, 3, 4, 5, 6, and 9 were purchased from ChemDiv, ChemicalDiversity (San-Diego, CA, USA).

METHODS OF INHIBITING OSTEOCLAST ACTIVITY

MURALI,Ramachandran [US]; GREENE, Mark, I.[US];KINOSAKI,Masahiko [JP]

Publicationdate: 2001-02-08 | Patent publication No.: WO-2001008677-A1|Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US] | IPC: A61K31/00;A61K31/03; A61K31/235; A61K31/565; A61K31/585; A61K38/00; A61K38/17; C07K5/103;C07K5/107; C07K5/113; C07K14/705 | Oldestpriority date: 1999-07-28 | Publication date: 2001-02-08

Score: 19.22352 | Text size: 91866 | Find: similardocuments

entitledFormulae and are described in the table below which includes catalogue numbers from ChemDiv,Inc., San Diego, CA. ... entitled Formulae and are described in the tablebelow which includes catalogue numbers from ChemDiv, Inc., SanDiego, CA. ... entitled Formulae and are described in the table below whichincludes catalogue numbers from ChemDiv, Inc., San Diego, CA. ...entitled Formulae and are described in the table below which includes cataloguenumbers from ChemDiv, Inc., San Diego, CA. ... of Formulae VIII toXII and are described in the table below which includes catalogue numbersfrom ChemDiv, Inc., San Diego, CA.

Prevention of White Matter Injury in Premature Infants

MEDOSOME BIOTEC,LLC

Publicationdate: 2019-05-17

Originaldocument: NIH | Score: 18.324297 | Text size: 4981 | Find: similardocuments

who directthe University of Florida Translational Drug Development Core; Charles Riverand ChemDivLaboratories, which are CROs with extensive experiencein the execution of pre-IND testing; and

High-throughput Discovery of Chemical Probes for HIV-1 Nef Function

UNIVERSITY OFPITTSBURGH AT PITTSBURGH

Publicationdate: 2015-03-01

Original document: NIH | Score: 18.491371 | Text size: 5205 | Find: similar documents

Theseinclude 10,000 non-peptide peptidomimetics from ChemDiv designedto block diverse protein-protein interfaces and 50,000 structures selected fromthe

High-throughput Discovery of Chemical Probes for HIV-1 Nef Function

UNIVERSITY OF PITTSBURGHAT PITTSBURGH

Publicationdate: 2015-03-01

Originaldocument: NIH | Score: 18.491371 | Text size: 5207 | Find: similardocuments

Theseinclude 10,000 non-peptide peptidomimetics from ChemDiv designedto block diverse protein-protein interfaces and 50,000 structures selected fromthe

High-throughput Discovery of Chemical Probes for HIV-1 Nef Function

UNIVERSITY OFPITTSBURGH AT PITTSBURGH

Publicationdate: 2015-03-01

Originaldocument: NIH | Score: 18.491371 | Text size: 5263 | Find: similardocuments

Theseinclude 10,000 non-peptide peptidomimetics from ChemDiv designedto block diverse protein-protein interfaces and 50,000 structures selected fromthe

High-throughput Discovery of Chemical Probes for HIV-1 Nef Function

UNIVERSITY OFPITTSBURGH AT PITTSBURGH

Publicationdate: 2015-03-01

Original document: NIH | Score: 18.576057 | Text size: 5182 | Find: similar documents

Theseinclude 10,000 non-peptide peptidomimetics from ChemDiv designedto block diverse protein-protein interfaces and 50,000 structures selected fromthe

USP34 as a novel target for treatment of idiopathic pulmonary fibrosis

PROGENRA, INC.

Publicationdate: 2010-01-15

Originaldocument: NIH | Score: 18.160212 | Text size: 4292 | Find: similardocuments

Next, itwill be employed to screen three small molecule libraries - the ChemDiv ProteaseLibrary (2000 compounds), the Maybridge HitFinder diversity library (14,000compounds),

Discovery of Small Molecule hACC2 Inhibitors for Treatment of Obesity

CHEMDIV, INC.

Publicationdate: 2007-05-01

Originaldocument: NIH | Score: 19.282526 | Text size: 2414 | Find: similardocuments

CHEMDIV,INC.; City: SAN DIEGO; Country: UNITED STATES Project Start Date: 2007-05-01 ProjectEnd Date:

EXPLORATION OF NEW REGIONS OF DIVERSITY SPACE IN ERGOT-BASED LIBRARIES

CHEMDIV, INC.

Publicationdate: 2006-09-20

Originaldocument: NIH | Score: 19.191292 | Text size: 2945 | Find: similardocuments

CHEMDIV,INC.; City: SAN DIEGO; Country: UNITED STATES Project Start Date: 2006-09-20 ProjectEnd Date:

EXPLORATION OF NEW REGIONS OF DIVERSITY SPACE IN ERGOT-BASED LIBRARIES

CHEMDIV, INC.

Publicationdate: 2006-09-20

Originaldocument: NIH | Score: 19.704044 | Text size: 2042 | Find: similardocuments

CHEMDIV,INC.; City: SAN DIEGO; Country: UNITED STATES Project Start Date: 2006-09-20 ProjectEnd Date:

NEW REGIONS OF DIVERSITY SPACE IN ERGOT-BASED LIBRARIES

CHEMDIV, INC.

Publicationdate: 2006-09-20

Originaldocument: NIH | Score: 19.704044 | Text size: 2027 | Find: similardocuments

CHEMDIV,INC.; City: SAN DIEGO; Country: UNITED STATES Project Start Date: 2006-09-20 ProjectEnd Date:

Identification of Novel ACTH small molecule Antagonists

CHEMDIV, INC.

Publicationdate: 2004-09-30

Originaldocument: NIH | Score: 19.100918 | Text size: 2811 | Find: similardocuments

CHEMDIV,INC.; City: SAN DIEGO; Country: UNITED STATES Project Start Date: 2004-09-30Project End Date:

Identification of Novel ACTH Small Molecule Antagonists

CHEMDIV, INC.

Publicationdate: 2004-09-30

Originaldocument: NIH | Score: 21.956474 | Text size: 3169 | Find: similardocuments

CHEMDIV,INC.; City: SAN DIEGO; Country: UNITED STATES Project Start Date: 2004-09-30Project End Date: ... These studies combine ChemDiv's expertise indrug discovery with a Yale laboratory with expertise in GPCR action andtreatment of

Identification of Novel ACTH Small Molecule Antagonists

CHEMDIV, INC.

Publicationdate: 2004-09-30

Originaldocument: NIH | Score: 21.956474 | Text size: 3136 | Find: similardocuments

CHEMDIV,INC.; City: SAN DIEGO; Country: UNITED STATES Project Start Date: 2004-09-30Project End Date: ... These studies combine ChemDiv's expertise indrug discovery with a Yale laboratory with expertise in GPCR action andtreatment of

DRUG DISCOVERY FOR TREATMENT OF OBESITY

CHEMDIV, INC.

Publicationdate: 2004-05-01

Originaldocument: NIH | Score: 19.236801 | Text size: 2184 | Find: similardocuments

CHEMDIV,INC.; City: SAN DIEGO; Country: UNITED STATES Project Start Date: 2004-05-01 ProjectEnd Date:

A Phase 2A Evaluation of the Safety, Tolerability, Pharmacokinetics,Efficacy of Clofazimine (CFZ) in Cryptosporidiosis

Publisher: National Library of Medicine | Publicationdate: 2017-10-26

Score: 16.088373 | Text size: 76081 | Find: similardocuments

powders(> 95% purity) from Selleck Chemicals, Calbiochem, Ambinter, Enzo LifeSciences, NCI, ChemDiv, or Life Chemicals.

External link

Someinternal Publications

1. Ivachtchenko A.V., Dmitriev D.E., Golovina E.S., Dubrovskaya E.S.,Kadieva M.G., Koryakova A.G., Kysil V.M., Mitkin O.D., Tkachenko S.E., OkunI.M., Vorobiov A.A. Synthesis of cycloalkane-annelated3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT(6)receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 2010 Feb14. in press.

2. Kysil V., Khvat A., Tsirulnikov S., Tkachenko S, Williams C.,Churakova M., Ivachtchenko A. General Multicomponent Strategy for the Synthesisof 2-Amino-1,4-diazaheterocycles: Scope, Limitations, and Utility. EuropeanJournal of Organic Chemistry. 2010; 1525-1543.

3. Ivachtchenko A., Golovina E., Kadieva M., Koryakova A.,Kovalenko S., Mitkin O., Okun I., Ravnyeyko I., Tkachenko S., Zaremba O.Solution Phase Parallel Synthesis of Substituted 3-Phenylsulfonyl-[1,2,3]triazolo[1,5-a]quinazolines– Selective Serotonin 5-HT(6) Receptor Antagonists. Journal of CombinatorialChemistry. 2010; in press.

4. Ivachtchenko A.V., Mitkin O.D., Tkachenko S.E., Okun I.M.,Kysil V.M. 8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT(6)receptor antagonists. European Journal of Medicinal Chemistry. 2010; 45(2):782-789.

5. Ivachtchenko A.V., Frolov E.B., Mitkin O.D., Tkachenko S.E.,Okun I.M., Khvat A.V. Synthesis and biological activity of 5-styryl and5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. Bioorganic& Medicinal Chemistry Letters. 2010; 20(1): 78-82.

6. Okun I., Tkachenko S.E., Khvat A., Mitkin O., Kazey V.,Ivachtchenko V.A. From Anti-allergic to Anti-Alzheimer’s: MolecularPharmacology of Dimebon. Current Alzheimer Research. 2009 Nov 26. [Epub aheadof print].

7. Ivachtchenko A.V., Frolov E.B., Mitkin O.D., Kysil V.M.,Khvat A.V., Tkachenko S.E. Synthesis and Biological Evaluation of Novel5,8-Disubstituted-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indoles as5-HT(6) and H(1) Receptors Antagonists. Archiv der Pharmazie (Weinheim). 2009;342(12):740-747.

8. Tkachenko S., Ivachtchenko A., Okun I., Lavrovsky Y., MitkinO., Salimov R. P4-212: Comparision of highly selective and non-selective 5-HT6receptor antagonists in in vitro and in vivo neurodegenerative models.Alzheimer’s and Dementia. 2009; 4(4); Supplement 1: P492.

9. Ivachtchenko A.V., Frolov E.B., Mitkin O.D., Kysil V.M.,Khvat A.V., Okun I.M., Tkachenko S.E. Synthesis and biological evaluation ofnovel Î³-carboline analogues of Dimebon as potent 5-HT6 receptorantagonists. Bioorganic & Medicinal Chemistry Letters. 2009; 19(12):3183-3187.

10. Kysil V.M., Khvat A., Tsirulnikov S., Tkachenko S.,Ivachtchenko A. Multicomponent approach to unique 1,4-diazepine-2-amines.Tetrahedron Letters. 2009; 50(24): 2854-2856.

11. Balakin KV, Ivanenkov YA, Savchuk NP. Compound librarydesign for target families. Methods Molecular Biology. 2009; 575: 21-46.

12. Ivanenkov YA, Savchuk NP, Ekins S, Balakin KV. Computationalmapping tools for drug discovery. Drug Discovery Today. 2009; 14(15-16):767-75.
13. Bushkova E, Parchinsky V, Krasavin M. Efficient entry intohydrazinopeptide-like structures via sequential Ugi reactions. MolecularDiversity. 2009 Nov 10. [Epub ahead of print]

14. Krasavin M, Karapetian R, Konstantinov I, Gezentsvey Y,Bukhryakov K, Godovykh E, Soldatkina O, Lavrovsky Y, Sosnov AV, Gakh AA.Discovery and potency optimization of 2-amino-5-arylmethyl-1,3-thiazolederivatives as potential therapeutic agents for prostate cancer. Archiv derPharmazie (Weinheim). 2009; 342(7): 420-7.

15. Krasavin M, Shkavrov S, Parchinsky V, Bukhryakov K.Imidazo[1,2-a]quinoxalines accessed via two sequential isocyanide-based multicomponentreactions. Journal of Organic Chemistry. 2009; 74(6): 2627-9.

16. Salimov R., Tkachenko S. P1-019: Effect of Tacrine andDimebon on scopolamine- and dizocipline-induced memory impairment in mice.Alzheimer’s and Dementia. 2008; 4(4); Supplement 1: T211.

17. Tkachenko S.E. P2-478: Discovery and in vivo evaluation ofpotent 5-HT6 receptor antagonists for cognition enhancement in treatingAlzheimer’s disease. Alzheimer’s and Dementia. 2008; 4(4); Supplement 1: T514.

18. Sandulenko Yu.B., Ivashchenko A.V., Kravchenko D.V.,Tkachenko S.E., Vvedensky V.Yu. Parallel solid-phase synthesis of novel3,7-diazabicyclo[3.3.1]nonane derivatives starting from natural alkaloidcytisine. Russian Chemical Bulletin. 2008; 57(9): 1999-2004.

19. Ivanenkov Y.A., Balakin K.V., Tkachenko S.E. New approachesto the treatment of inflammatory disease: focus on small-molecule inhibitors ofsignal transduction pathways. Drugs in R&D. 2008; 9(6): 397-434.

20. Balakin K.V., Ivanenkov Y.A., Tkachenko S.E., Kiselyov A.S.,Ivachtchenko A.V. Regulators of chemokine receptor activity as promisinganticancer therapeutics. Current Cancer Drug Targets. 2008; 8(4): 299-34.

21. Okun I., Balakin K.V., Tkachenko S.E., Ivachtchenko A.V.Caspase activity modulators as anticancer agents. Anti-Cancer Agents inMedicinal Chemistry. 2008; 8(3): 322-341.

22. Lavrovsky Y, Ivanenkov YA, Balakin KV, Medvedeva DA,Ivachtchenko AV. CXCR4 receptor as a promising target for oncolytic drugs. MiniReviews in Medicinal Chemistry. 2008; 8(11): 1075-87.

23. Chekmarev DS, Kholodovych V, Balakin KV, Ivanenkov Y, EkinsS, Welsh WJ. Shape signatures: new descriptors for predicting cardiotoxicity insilico. Chemical Research in Toxicology. 2008; 21(6): 1304-14.

24. Koryakova AG, Ivanenkov YA, Ryzhova EA, Bulanova EA,Karapetian RN, Mikitas OV, Katrukha EA, Kazey VI, Okun I, Kravchenko DV,Lavrovsky YV, Korzinov OM, Ivachtchenko AV. Novel aryl and heteroarylsubstitutedN-[3-(4-phenylpiperazin-1-yl)propyl]-1,2,4-oxadiazole-5-carboxamides asselective GSK-3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008;18(12): 3661-6.

25. Ivachtchenko A.V.; Kiselyov A.S.; Tkachenko S.E.; IvanenkovY.A.; Balakin K.V. Novel Mitotic Targets and Their Small-Molecule Inhibitors.Current Cancer Drug Targets. 2007; 7(8): 766-784.

26. Balakin K.V., Ivanenkov Y.A., Kiselyov A.S., Tkachenko S.E.Histone deacetylase inhibitors in cancer therapy: latest developments, trendsand medicinal chemistry perspective. Anti-Cancer Agents in Medicinal Chemistry.2007; 7(5): 576-92.

27. Kysil V., Tkachenko S., Khvat A., Williams C., TsirulnikovS., Churakova M., Ivachtchenko A. TMSCl-Promoted Isocyanide-Based MCR ofEthylenediamines: an Efficient Assembling of 2-Aminopyrazine Core. TetrahedronLetters, 2007; 48(36): 6239-6244.

28. Kiselyov A.S., Tkachenko S.E., Balakin K.V., IvachtchenkoA.V. Small-molecule modulators of Hh and Wnt signaling pathways. Expert Opinionon Therapeutic Targets. 2007; 11(8): 1087-1101.

29. Kiselyov A.S., Balakin K.V., Tkachenko S.E., Savchuk N.P.,Ivachtchenko A.V. Recent Progress in Discovery of Antimitotic Agent.Anti-Cancer Agents in Medicinal Chemistry. 2007; 7: 189-208.

30. Ilyin AP, Dmitrieva IG, Kustova VA, Manaev AV, IvachtchenkoAV. Synthesis of heterocyclic compounds possessing the 4H-thieno[3,2-b]pyrrolemoiety. Journal of Combinatorial Chemistry. 2007; 9(1): 96-106.

31. Balakin K.V., Tkachenko S.E., Kiselyov A.S., Savchuk N.P.Focused chemistry from annotated libraries. Drug Discovery Today: Technologies.2006; 3(4): 397-403.

32. Kiselyov A., Balakin K.V., Tkachenko S.E. VEGF/VEGFRsignalling as a target for inhibiting angiogenesis. Expert Opinion onInvestigational Drugs. 2007; 16(1): 83-107.

33. Dorogov M.V., Ivanovsky S.A., Khakhina M.Y., KravchenkoD.V., Tkachenko S.E., Ivachtchenko A.V. Synthesis of 7-sulfamoyl-substituted2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepines. Synthetic Communications. 2006;36(23): 3525-3535

34. Savchuk N.P., Tkachenko S.E., Balakin K.V. Design ofpGPCR-targeted Libraries. In Rognan D., ed. Ligand Design for G Protein-coupledReceptors. Methods and Principles in Medicinal Chemistry (Volume 30). Weinheim:Wiley VCH. 2006, pp. 137-164.

35. Filimonov S.I., Korsakov M.K., Kravchenko D.V., DorogovM.V., Tkachenko S.E., Ivachtchenko A.V. Convenient synthesis of novel5-substituted 3-methylisoxazole-4-sulfonamides. Journal of HeterocyclicChemistry. 2006; 43(3): 663-671.

36. Okun I., Malarchuk S., Dubrovskaya E., Khvat A., TkachenkoS., Kysil V., Kravchenko D., Ivachtchenko A. Screening for Caspase-3Inhibitors: Effect of a Reducing Agent on Identified Hit Chemotypes. Journal ofBiomolecular Screening. 2006; 11(6): 694-703.

37. Kravchenko D.V., Kysil V.M., Tkachenko S.E., Maliarchouk S.,Okun I.M., Ivachtchenko A.V. New variant of the Pfizinger reaction. Synthesisand chemical transformations of substituted2-aminomethyl-quinoline-3,4-dicarboxylic acids. Heterocyclic Communications.2006; 12(1): 15-18.

38. Trifilenkov A.S., Kobak V.V., Kuzovkova J.A., Ilyin A.P.,Khvat A.V., Tkachenko S.E., Ivachtchenko A.V. Liquid-Phase Parallel Synthesisof Combinatorial Libraries of Substituted6-Carbamoyl-3,4-dihydro-2H-benzo[1,4]thiazines. Journal of CombinatorialChemistry. 2006; 8(4): 469-479.

39. Kiselyov A., Balakin K.V., Tkachenko S.E., Savchuk N.P.Recent Progress in Development of Non-ATP Competitive Small-Molecule Inhibitorsof Protein Kinases. Mini Reviews in Medicinal Chemistry. 2006; 6(6): 711-717.

40. Shevyakov S.V., Davydova O.I., Pershin D.G., Krasavin M.,Kravchenko D.V., Kiselyov A., Tkachenko S.E., Ivachtchenko A.V. Naturalproducts as templates for bioactive compound libraries: synthesis of biarylderivatives of (+/-)-vasicine. Natural Product Research. 2006; 20(8): 735-741.

41. Ilyn A.P., Loseva M.V., Vvedensky V.Y., Putsykina E.B.,Tkachenko S.E., Kravchenko D.V., Khvat A.V., Krasavin M.Y., Ivachtchenko A.V.One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines.Journal of Organic Chemistry. 2006; 71(7): 2811-2819.

42. Bologa C.G., Revankar C.M., Young S.M., Edwards B.S.,Arterburn J.B., Kiselyov A.S., Parker M.A., Tkachenko S.E., Savchuck N.P.,Sklar L.A., Oprea T.I., Prossnitz E.R. Virtual and biomolecular screeningconverge on a selective agonist for GPR30. Nature Chemical Biology. 2006; 2(4):207-212.

43. Kravchenko D.V., Kuzovkova J.A., Kysil V.M. Tkachenko S.E.,Malarchuk S., Okun I.M., Ivachtchenko A.V. Pyrrolo[3,4-c]Quinoline-1,3-Dionesas Potent Caspase-3 Inhibitors: Synthesis and SAR of8-Sulfamoyl-1,3-Dioxo-2,3-Dihydro-1H-Pyrrolo[3,4- c]Quinolines. Letters in DrugDesign & Discovery. 2006; 3(1): 61-70.

44. Okun I., Malarchuk S., Dubrovskaya E., Khvat A., TkachenkoS., Kysil V., Ilyin A., Kravchenko D., Prossnitz E.R., Sklar L., IvachtchenkoA. Screening for Caspase-3 Inhibitors: A New Class of Potent Small-MoleculeInhibitors of Caspase-3. Journal of Biomolecular Screening. 2006; 11(3):277-85.

45. Kravchenko D.V., Kysil V.M., Ilyn A.P., Tkachenko S.E.,Maliarchouk S., Okun I.M., Ivachtchenko A.V. Synthesis and ChemicalTransformations of 6-(Morpholine-4-sulfonyl)-quinoline-2,3,4-tricarboxylicAcid. Synthetic Communications. 2006; 36: 911-917.

46. Ilyin A.P., Kobak V.V., Dmitrieva I.G., Peregudova Y.N.,Kustova V.A., Mishunina Y.S., Ivachtchenko A.V. Synthesis of7,8-Dihydrothieno-[3′,2′:4,5]pyrrolo[1,2-a]pyrazin-5(6H)-ones Usinga Modification of Four-Component Ugi Reaction. Synthetic Communications. 2006;36: 903-910.

47. Ilyin A.P., Parchinski V.Z., Peregudova J.N., Tri.lenkovA.S., Poutsykina E.B., Tkachenko S.E., Kravchenko D.V. Ivachtchenko A.V.One-step assembly of carbamoyl substituted annulated 1,4-oxazepines.Tetrahedron Letters. 2006; 47(15): 2649-2653.

48. Ekins S, Balakin KV, Savchuk N, Ivanenkov Y. Insights forhuman ether-a-go-go-related gene potassium channel inhibition using recursivepartitioning and Kohonen and Sammon mapping techniques. Journal of MedicinalChemistry. 2006; 49(17): 5059-71.

49. Balakin KV, Kozintsev AV, Kiselyov AS, Savchuk NP. Rationaldesign approaches to chemical libraries for hit identification. Current DrugDiscovery Technologies. 2006; 3(1): 49-65.

50. Balakin KV, Savchuk NP, Tetko IV. In silico approaches toprediction of aqueous and DMSO solubility of drug-like compounds: trends,problems and solutions. Current Medicinal Chemistry. 2006; 13(2): 223-41.

51. Shevyakov SV, Davydova OI, Kiselyov AS, Kravchenko DV,Ivachtchenko AV, Krasavin M. Natural products as templates for bioactivecompound libraries: part 2. Novel modifications of vasicine (peganine) core viaefficient and regioselective generation of 3-lithiodeoxyvasicine and itsstereoselective addition to aliphatic ketones section sign. Natural ProductResearch. 2006; 20(9): 871-81.

52. Ilyin A, Kysil V, Krasavin M, Kurashvili I, Ivachtchenko AV.Complexity-enhancing acid-promoted rearrangement of tricyclic products oftandem Ugi 4CC/intramolecular Diels-Alder reaction. Journal of OrganicChemistry. 2006; 71(25): 9544-7.

53. Kravchenko D.V., Kysil V.M., Tkachenko S.E., Maliarchouk S.,Okun I.M., Ivachtchenko A.V. Synthesis and caspase-3 inhibitory activity of8-sulfonyl-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines. Farmaco. 2005;60(10): 804-9.

54. Ilyin A.P., Kobak V.V., Dmitrieva I.G., Peregudova Y.N.,Kustova V.A., Mishunina Y.S., Tkachenko S.E., Ivachtchenko A.V. Synthesis ofannelated azaheterocycles containing a 5-carbamoylpyrazin-3-one fragment by amodification of the four-component Ugi reaction. European Journal of OrganicChemistry. 2005; (21): 4670-4679.

55. Kravchenko D.V., Kysil V.M., Tkachenko S.E., Maliarchouk S.,Okun I.M., Ivachtchenko A.V. Pyrrolo[3,4-c]quinoline-1,3-diones as potentcaspase-3 inhibitors. Synthesis and SAR of 2-substituted4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones. EuropeanJournal of Medicinal Chemistry. 2005; 40(12): 1377-1383.

56. Vvedensky V.Y., Ivanov Y.V., Kysil V., Williams C.,Tkachenko S., Kiselyov A., Khvat A.V., Ivachtchenko A.V. Microwave-mediatedreactions of 3-aminomethylpyridines with acetylenedicarboxylates. A novelsynthetic route to dihydronaphthyridines and naphthyridine-1-ones TetrahedronLetters. 2005; 46: 3953-3956.

57. Kravchenko D.V., Kysil V.M., Ilyn A.P., Tkachenko S.E.,Maliarchouk S., Okun I.M., Ivachtchenko A.V.1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3inhibitors. Bioorganic & Medicinal Chemistry Letters. 2005; 15(7):1841-1845.

58. Kravchenko D.V., Kuzovkova Y.A., Kysil V.M., Tkachenko S.E.,Maliarchouk S., Okun I.M., Balakin K.V., Ivachtchenko A.V. Synthesis andStructure-Activity Relationship of 4-Substituted2-(2-Acetyloxyethyl)-8-(morpholine- 4-sulfonyl)pyrrolo[3,4-c]quinoline- 1,3-dionesas Potent Caspase-3 Inhibitors Journal of Medicinal Chemistry. 2005; 48(11):3680-3683.

59. Ilyin A.P., Kuzovkova J.A., Potapov V.V., Shkirando A.M.,Kovrigin D.I., Tkachenko S.E., Ivachtchenko A.V. An efficient synthesis ofnovel heterocycle-fused derivatives of 1-oxo-1,2,3,4-tetrahydropyrazine usingUgi condensation. Tetrahedron Letters. 2005; 46(5): 881-884.

60. Balakin KV, Ivanenkov YA, Savchuk NP, Ivashchenko AA, EkinsS. Comprehensive computational assessment of ADME properties using mapping techniques.Current Drug Discovery Technologies. 2005; 2(2): 99-113.

61. Zhuravel’ IO, Kovalenko SM, Ivachtchenko AV, Balakin KV,Kazmirchuk VV. Synthesis and antimicrobial activity of 5-hydroxymethyl-8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides.Bioorganic & Medicinal Chemistry Letters. 2005; 15(24):5483-7.

62. Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER,Savchuck NP, Sklar LA, Oprea TI. Integration of virtual screening withhigh-throughput flow cytometry to identify novel small molecule formylpeptidereceptor antagonists. Molecular Pharmacology. 2005; 68(5): 1301-10.

63. Savchuk N.P., Tkachenko S.E., Balakin K.V. Rational designof GPCR-specific combinatorial libraries based on the concept of privilegedsubstructures. In T Oprea, ed. Cheminformatics in Drug Discovery. Weinheim:Wiley VCH. 2005, pp. 287-313.

64. Ilyn AP, Trifilenkov AS, Tsirulnikov SA, Kurashvily ID,Ivachtchenko AV. Synthesis of4-Oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-6-carboxamides using a modificationof Ugi condensation. Journal of Combinatorial Chemistry. 2005; 7(6):806-8.

65. Ilyin AP, Trifilenkov AS, Kurashvili ID, Krasavin M,Ivachtchenko AV. One-step construction of peptidomimetic5-carbamoyl-4-sulfonyl-2-piperazinones. Journal of Combinatorial Chemistry.2005; 7(3): 360-3.

66. Ivachtchenko AV, Kobak VV, Ilyn AP, Khvat AV, Kysil VM,Williams CT, Kuzovkova JA, Kravchenko DV. Parallel liquid-phase synthesis ofN-substituted 6-aminosulfonyl-2-oxo-1,2-dihydroquinoline-4-carboxamide and6-aminosulfonylquinoline-4-carboxamide derivatives. Journal of CombinatorialChemistry. 2005; 7(2): 227-35.

67. Ilyn AP, Trifilenkov AS, Kuzovkova JA, Kutepov SA, NikitinAV, Ivachtchenko AV. New four-component Ugi-type reaction. Synthesis ofheterocyclic structures containing a pyrrolo[1,2-a][1,4]diazepine fragment.Journal of Organic Chemistry. 2005; 70(4): 1478-81.

68. Ivachtchenko A.V., Tkachenko S.E., Khvat A.V., SandulenkoY.V., Vvedensky V.Y. A parallel solution-phase synthesis of substituted3,7-diazabicyclo[3.3.1]nonanes. Journal of Combinatorial Chemistry. 2004; 6(5):828-834.

69. Ivachtchenko A.V., Khvat A.V., Tkachenko S.E., SandulenkoY.B., Vvedensky V.Y. Access to novel substituted diazaadamantanes viaseminatural tetrahydrocytisine. Tetrahedron Letters. 2004; 45(36): 6733-6736.

70. Savchuk N.P., Balakin K.V., Tkachenko S.E. Exploring thechemogenomic knowledge space with annotated chemical libraries. Current Opinionin Chemical Biology. 2004; 8(4): 412-417.

71. Balakin A., Tkachenko S., .Okun I., Scorenko A., IvanenkovY., Savchuk N., Ivashchenko A., Nikolsky Y. Bioisosteric Morphing in PrimaryHit Optimization. Chimica OGGI/Chemistry Today. 2004; 22(1/2): 15-18.

72. Tkachenko S., Okun I., Balakin K., Petersen C., IvanenkovY., Savchuk N., Ivashchenko A. Efficient Optimization Strategy for MarginalHits Active Against abl Tyrosine Kinases. Current Drug Discovery Technologies.2004; 1(3): 201-210.

73. Balakin KV, Ekins S, Bugrim A, Ivanenkov YA, Korolev D,Nikolsky YV, Ivashchenko AA, Savchuk NP, Nikolskaya T. Quantitativestructure-metabolism relationship modeling of metabolic N-dealkylation reactionrates. Drug Metabolism and Disposition. 2004; 32(10): 1111-20.

74. Balakin KV, Ekins S, Bugrim A, Ivanenkov YA, Korolev D,Nikolsky YV, Skorenko AV, Ivashchenko AA, Savchuk NP, Nikolskaya T. Kohonenmaps for prediction of binding to human cytochrome P450 3A4. Drug Metabolismand Disposition. 2004; 32(10): 1183-9.

75. Balakin KV, Ivanenkov YA, Skorenko AV, Nikolsky YV, SavchukNP, Ivashchenko AA. In silico estimation of DMSO solubility of organiccompounds for bioscreening. Journal of Biomolecular Screening. 2004; 9(1):22-31.

76. Balakin K.V., Lang S.A., Skorenko A.V., Tkachenko S.E.,Ivashchenko A.A., Savchuk N.P. Structure-based versus property-based approachesin the design of G-protein-coupled receptor-targeted libraries. Journal ofChemical Information and Computer Science. 2003; 43(5): 1553-1562.

77. Ivanenkov Ya., Balakin K., Skorenko A., Tkachenko S.,Savchuk N., Ivashchenko A.A., Nikolsky Yu. Application of advanced machinelearning algorithm for profiling specific GPCR-active compounds. ChimicaOGGI/Chemistry Today. 2003; 21(6): 72-75.

78. Balakin AV, Lang SA, Tkachenko SE, Ivashchenko A.A., SavchukN.P. Pre-synthetic Combinatorial Design: Trends Toward IntelligentComputational Technologies. Chimica OGGI/Chemistry Today. 2003; 21(3/4): 63-66.

79. Zernov VV, Balakin KV, Ivaschenko AA, Savchuk NP, PletnevIV. Drug discovery using support vector machines. The case studies ofdrug-likeness, agrochemical-likeness, and enzyme inhibition predictions.Journal of Chemical Information and Computer Science. 2003; 43(6): 2048-56.

80. Korolev D, Balakin KV, Nikolsky Y, Kirillov E, Ivanenkov YA,Savchuk NP, Ivashchenko AA, Nikolskaya T. Modeling of human cytochrome p450-mediateddrug metabolism using unsupervised machine learning approach. Journal ofMedicinal Chemistry. 2003; 46(17): 3631-43.

81. Trepalin SV, Skorenko AV, Balakin KV, Nasonov AF, Lang SA,Ivashchenko AA, Savchuk NP. Advanced exact structure searching in largedatabases of chemical compounds. Journal of Chemical Information and ComputerScience. 2003; 43(3): 852-60.

82. Ivachtchenko AV, Kovalenko SM, Drushlyak OG. Synthesis ofsubstituted 4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolines and 4-oxo-3,4-dihydroquinazoline-2-thioles.Journal of Combinatorial Chemistry. 2003; 5(6): 775-88.

83. Balakin AV, Tkachenko SE, Lang SA, Okun IM, Ivashchenko AA,Savchuk NP. Property-Based Design of GPCR-Targeted Library. Journal of ChemicalInformation and Computer Science. 2002; 42(6): 1332-1346.

84. Ivachtchenko AV, Il’yin AP, Kobak VV, Zolotarev DA, BokshaLV, Trifilenkov AS, Ugoleva DM. New scaffolds for combinatorial synthesis. 1.5-sulfamoylisatins and their reactions with 1,2-diamines. Journal ofCombinatorial Chemistry. 2002; 4(5): 419-28.