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DNA encoded libraries-CDI-capabilities

DNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilitiesDNA encoded libraries-CDI-capabilities

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ChemDiv proposes design and synthesis of heterocyclic scaffolds for DEL:
 
Vast diversity of heterocyclic scaffolds,

Proprietary and continuously validated reactions and library protocols

 
High Fsp3 scaffolds
  • Flexible and conformationally constrained cores
  • Derivatives and mimics of natural compounds
  • Poly-functional derivatization
  • Multiple diversity points, ≥ 3
 
Defined chirality
  • Confirmed relative stereochemistry
  • Confirmed absolute stereochemistry

Protein-Protein Interaction modulation as a focus:

  • Macrocycles
  • Spiro-cycles
  • Natural templates

DNA Encoded Libraries-CDI-Capabilities

We offer vast diversity of heterocyclic scaffolds, proprietary and continuously validated reactions and library protocols, high Fsp3 scaffolds, flexible and conformationally constrained cores, derivatives and mimics of natural compounds, poly-functional derivatization with multiple diversity points and defined chirality or protein-protein interaction as a focus. Advantages of DNA-encoded libraries are:

  •       Easy preparation
  •       Easy deconvolution
  •       Large chemistry space
  •       Full library enumeration
  •       Validated u-HTS techniques

Challenges include the lack of scaffold diversity, limitations in synthetic methods.

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