4358-1580 Screening compound: 2-(2,4-dichlorophenyl)-N-[4-(morpholin-4-yl)phenyl]quinazolin-4-amine

4358-1580 Screening compound: 2-(2,4-dichlorophenyl)-N-[4-(morpholin-4-yl)phenyl]quinazolin-4-amine
4358-1580 Screening compound: 2-(2,4-dichlorophenyl)-N-[4-(morpholin-4-yl)phenyl]quinazolin-4-amine alternative view

Chemical Structure Depiction of ChemDiv screening compound 4358-1580
2-(2,4-dichlorophenyl)-N-[4-(morpholin-4-yl)phenyl]quinazolin-4-amine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

4358-1580

Molecular Formula

C24H20Cl2N4O (C24 H20 Cl2 N4 O)

Compound Name

2-(2,4-dichlorophenyl)-N-[4-(morpholin-4-yl)phenyl]quinazolin-4-amine

IUPAC name

2-(24-dichlorophenyl)-N-[4-(morpholin-4-yl)phenyl]quinazolin-4-amine

SMILES

Clc(cc1)cc(Cl)c1-c1nc2ccccc2c(Nc(cc2)ccc2N2CCOCC2)n1

InChI

InChI=1S/C24H20Cl2N4O/c25-16-5-10-19(21(26)15-16)23-28-22-4-2-1-3-20(22)24(29-23)27-17-6-8-18(9-7-17)30-11-13-31-14-12-30/h1-10,15H,11-14H2,(H,27,28,29)

InChI Key

GHQJKIFHPXMJKJ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD08052337

Chemical and Physical Properties

Saltdata

HCl

Molecular Weight

451.35

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

6.051

Distribution Coefficient, logD

5.992

Water Solubility, LogSw

-6.42

Polar Surface Area

39.166

Acid Dissociation Constant (pKa)

18.17

Base Dissociation Constant (pKb)

6.56

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

16.70

4358-1580 in Drug Discovery

Included in Screening Libraries

Antimitotic Tubulin Library (17355 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

PI3K-Targeted Library (17255 compounds)

Akt-Targeted Library (14764 compounds)

Epigenetics Focused Set (26518 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Targets:
  • Kinases
  • Kinases
  • Phosphatases

References: we are preparing a list of scientific research reports with 4358-1580 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound 4358-1580?
Check Price and Availability of 4358-1580, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of 4358-1580 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for 4358-1580
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for 4358-1580
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of 4358-1580 available by request