6392-0369 Screening compound: (2E)-3-[2-(4-chloro-3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(3-ethoxypropyl)prop-2-enamide

6392-0369 Screening compound: (2E)-3-[2-(4-chloro-3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(3-ethoxypropyl)prop-2-enamide
6392-0369 Screening compound: (2E)-3-[2-(4-chloro-3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(3-ethoxypropyl)prop-2-enamide alternative view

Chemical Structure Depiction of ChemDiv screening compound 6392-0369
(2E)-3-[2-(4-chloro-3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(3-ethoxypropyl)prop-2-enamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

6392-0369

Molecular Formula

C24H23ClN4O4 (C24 H23 ClN4 O4)

Compound Name

(2E)-3-[2-(4-chloro-3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(3-ethoxypropyl)prop-2-enamide

IUPAC name

(2E)-3-[2-(4-chloro-3-methylphenoxy)-4-oxo-4H-pyrido[12-a]pyrimidin-3-yl]-2-cyano-N-(3-ethoxypropyl)prop-2-enamide

SMILES

CCOCCCNC(/C(/C#N)=C/C(C(N(C=CC=C1)C1=N1)=O)=C1Oc(cc1)cc(C)c1Cl)=O

InChI

InChI=1S/C24H23ClN4O4/c1-3-32-12-6-10-27-22(30)17(15-26)14-19-23(33-18-8-9-20(25)16(2)13-18)28-21-7-4-5-11-29(21)24(19)31/h4-5,7-9,11,13-14H,3,6,10,12H2,1-2H3,(H,27,30)

InChI Key

ZGKPXJVBBJDFQV-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD04154723

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

466.92

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

11.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.351

Distribution Coefficient, logD

3.351

Water Solubility, LogSw

-3.75

Polar Surface Area

82.302

Acid Dissociation Constant (pKa)

10.88

Base Dissociation Constant (pKb)

0.56

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

25.00

6392-0369 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

Covalent Inhibitors Library (7986 compounds)

?ysteine Targeted Covalent Library (39471 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases
Structure:
  • Cyclic compounds
  • 3D
  • Fragments

References: we are preparing a list of scientific research reports with 6392-0369 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound 6392-0369?
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What is the minimum amount of 6392-0369 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for 6392-0369
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for 6392-0369
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of 6392-0369 available by request