6528-0120 Screening compound: 3'-(4-chlorobenzoyl)-4'-hydroxy-1'-[(oxolan-2-yl)methyl]-1-(prop-2-en-1-yl)-1,1',2,5'-tetrahydrospiro[indole-3,2'-pyrrole]-2,5'-dione

6528-0120 Screening compound: 3'-(4-chlorobenzoyl)-4'-hydroxy-1'-[(oxolan-2-yl)methyl]-1-(prop-2-en-1-yl)-1,1',2,5'-tetrahydrospiro[indole-3,2'-pyrrole]-2,5'-dione
6528-0120 Screening compound: 3'-(4-chlorobenzoyl)-4'-hydroxy-1'-[(oxolan-2-yl)methyl]-1-(prop-2-en-1-yl)-1,1',2,5'-tetrahydrospiro[indole-3,2'-pyrrole]-2,5'-dione alternative view

Chemical Structure Depiction of ChemDiv screening compound 6528-0120
3'-(4-chlorobenzoyl)-4'-hydroxy-1'-[(oxolan-2-yl)methyl]-1-(prop-2-en-1-yl)-1,1',2,5'-tetrahydrospiro[indole-3,2'-pyrrole]-2,5'-dione

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

6528-0120

Molecular Formula

C26H23ClN2O5 (C26 H23 ClN2 O5)

Compound Name

3'-(4-chlorobenzoyl)-4'-hydroxy-1'-[(oxolan-2-yl)methyl]-1-(prop-2-en-1-yl)-1,1',2,5'-tetrahydrospiro[indole-3,2'-pyrrole]-2,5'-dione

IUPAC name

3'-(4-chlorobenzoyl)-4'-hydroxy-1'-[(oxolan-2-yl)methyl]-1-(prop-2-en-1-yl)-11'25'-tetrahydrospiro[indole-32'-pyrrole]-25'-dione

SMILES

C=CCN(C(C1(C(C(c(cc2)ccc2Cl)=O)=C2O)N(CC3OCCC3)C2=O)=O)c2c1cccc2

InChI

InChI=1S/C26H23ClN2O5/c1-2-13-28-20-8-4-3-7-19(20)26(25(28)33)21(22(30)16-9-11-17(27)12-10-16)23(31)24(32)29(26)15-18-6-5-14-34-18/h2-4,7-12,18,31H,1,5-6,13-15H2

InChI Key

WZKMZULDVNCVRR-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD04448697

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

478.93

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.391

Distribution Coefficient, logD

3.388

Water Solubility, LogSw

-4.12

Polar Surface Area

68.634

Acid Dissociation Constant (pKa)

9.57

Base Dissociation Constant (pKb)

-2.11

Number of Chiral Centers

2.00

Percent sp3 carbon bonding

26.90

6528-0120 in Drug Discovery

Included in Screening Libraries

Protein Arginine Methyltransferases Library (27925 compounds)

Protein-Protein Interaction Library (218420 compounds)

Spiro Library (21655 compounds)

Akt-Targeted Library (14764 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

MCE-18 Trends in Medicinal Chemistry (51288 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Others
  • Kinases
Mechanism of action:
  • Epigenetic
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds
  • Cyclic compounds

References: we are preparing a list of scientific research reports with 6528-0120 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound 6528-0120?
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What is the minimum amount of 6528-0120 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for 6528-0120
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for 6528-0120
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of 6528-0120 available by request