8014-1484 Screening compound: 6-chloro-3-[4-(2-hydroxyethyl)piperazino]-4-phenyl-2(1H)-quinolinone

8014-1484 Screening compound: 6-chloro-3-[4-(2-hydroxyethyl)piperazino]-4-phenyl-2(1H)-quinolinone
8014-1484 Screening compound: 6-chloro-3-[4-(2-hydroxyethyl)piperazino]-4-phenyl-2(1H)-quinolinone alternative view

Chemical Structure Depiction of ChemDiv screening compound 8014-1484
6-chloro-3-[4-(2-hydroxyethyl)piperazino]-4-phenyl-2(1H)-quinolinone

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

8014-1484

Molecular Formula

C21H22ClN3O2 (C21 H22 ClN3 O2)

Compound Name

6-chloro-3-[4-(2-hydroxyethyl)piperazino]-4-phenyl-2(1H)-quinolinone

IUPAC name

6-chloro-3-[4-(2-hydroxyethyl)piperazin-1-yl]-4-phenyl-12-dihydroquinolin-2-one

SMILES

OCCN(CC1)CCN1C1=C(c2ccccc2)c(cc(cc2)Cl)c2NC1=O

InChI

InChI=1S/C21H22ClN3O2/c22-16-6-7-18-17(14-16)19(15-4-2-1-3-5-15)20(21(27)23-18)25-10-8-24(9-11-25)12-13-26/h1-7,14,26H,8-13H2,(H,23,27)

InChI Key

XLYSDMZAMKIWBN-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD03488937

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

383.88

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

3.433

Distribution Coefficient, logD

3.333

Water Solubility, LogSw

-3.89

Polar Surface Area

48.661

Acid Dissociation Constant (pKa)

8.04

Base Dissociation Constant (pKb)

5.82

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

28.57

8014-1484 in Drug Discovery

Included in Screening Libraries

3CLpro Library (4801 compounds)

Anti-infective Library (19449 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

CNS Targets (44014 compounds)

CORONAVIRUS Library (20774 compounds)

Neurotransmitter Transporter Inhibitors Library (11024 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Antiviral
  • Infections
  • Immune system
  • Infections
  • Immune system
  • animal
  • Nervous system
  • Antiviral
  • Infections
  • Immune system
  • Nervous system
Targets:
  • GPCR
  • Ion Channels

References: we are preparing a list of scientific research reports with 8014-1484 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound 8014-1484?
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What is the minimum amount of 8014-1484 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for 8014-1484
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for 8014-1484
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of 8014-1484 available by request