8018-2159 Screening compound: 2-amino-5-oxo-4-(2,4,5-trimethoxyphenyl)-5H-pyrido[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-3-yl cyanide

8018-2159 Screening compound: 2-amino-5-oxo-4-(2,4,5-trimethoxyphenyl)-5H-pyrido[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-3-yl cyanide
8018-2159 Screening compound: 2-amino-5-oxo-4-(2,4,5-trimethoxyphenyl)-5H-pyrido[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-3-yl cyanide alternative view

Chemical Structure Depiction of ChemDiv screening compound 8018-2159
2-amino-5-oxo-4-(2,4,5-trimethoxyphenyl)-5H-pyrido[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-3-yl cyanide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

8018-2159

Molecular Formula

C19H15N5O4S (C19 H15 N5 O4 S)

Compound Name

2-amino-5-oxo-4-(2,4,5-trimethoxyphenyl)-5H-pyrido[3,2-e][1,3]thiazolo[3,2-a]pyrimidin-3-yl cyanide

IUPAC name

12-amino-8-oxo-10-(245-trimethoxyphenyl)-5-thia-2713-triazatricyclo[7.4.0.0^{26}]trideca-1(9)361012-pentaene-11-carbonitrile

SMILES

COc(cc(c(OC)c1)OC)c1-c(c(C(N=C1SC=CN11)=O)c1nc1N)c1C#N

InChI

InChI=1S/C19H15N5O4S/c1-26-11-7-13(28-3)12(27-2)6-9(11)14-10(8-20)16(21)22-17-15(14)18(25)23-19-24(17)4-5-29-19/h4-7H,1-3H3,(H2,21,22)

InChI Key

UAAZABCYKSRJTI-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD07657360

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

409.43

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

1.559

Distribution Coefficient, logD

1.559

Water Solubility, LogSw

-2.19

Polar Surface Area

95.462

Acid Dissociation Constant (pKa)

16.99

Base Dissociation Constant (pKb)

1.99

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

15.80

8018-2159 in Drug Discovery

Included in Screening Libraries

Antimitotic Tubulin Library (17355 compounds)

C-Met Library (15277 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
Targets:
  • Kinases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with 8018-2159 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound 8018-2159?
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What is the minimum amount of 8018-2159 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for 8018-2159
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for 8018-2159
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of 8018-2159 available by request