C154-0026 Screening compound: N-(5-chloro-2-methoxyphenyl)-2-methyl-1-oxo-3-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

C154-0026 Screening compound: N-(5-chloro-2-methoxyphenyl)-2-methyl-1-oxo-3-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide
C154-0026 Screening compound: N-(5-chloro-2-methoxyphenyl)-2-methyl-1-oxo-3-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound C154-0026
N-(5-chloro-2-methoxyphenyl)-2-methyl-1-oxo-3-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

C154-0026

Molecular Formula

C22H19ClN2O3S (C22 H19 ClN2 O3 S)

Compound Name

N-(5-chloro-2-methoxyphenyl)-2-methyl-1-oxo-3-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

IUPAC name

N-(5-chloro-2-methoxyphenyl)-2-methyl-1-oxo-3-(thiophen-2-yl)-1234-tetrahydroisoquinoline-4-carboxamide

SMILES

CN(C(C(C(Nc(cc(cc1)Cl)c1OC)=O)c1c2cccc1)c1cccs1)C2=O

InChI

InChI=1S/C22H19ClN2O3S/c1-25-20(18-8-5-11-29-18)19(14-6-3-4-7-15(14)22(25)27)21(26)24-16-12-13(23)9-10-17(16)28-2/h3-12,19-20H,1-2H3,(H,24,26)

InChI Key

VNCJJNANIPHQDN-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14723160

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

426.92

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

3.811

Distribution Coefficient, logD

3.685

Water Solubility, LogSw

-4.32

Polar Surface Area

46.731

Acid Dissociation Constant (pKa)

7.87

Base Dissociation Constant (pKb)

-0.68

Number of Chiral Centers

2.00

Percent sp3 carbon bonding

18.20

C154-0026 in Drug Discovery

Included in Screening Libraries

MCE-18 Trends in Medicinal Chemistry (51288 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with C154-0026 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound C154-0026?
Check Price and Availability of C154-0026, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of C154-0026 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for C154-0026
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for C154-0026
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of C154-0026 available by request