D278-0546 Screening compound: 6-methyl-2-(methylsulfanyl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-4-amine

D278-0546 Screening compound: 6-methyl-2-(methylsulfanyl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-4-amine
D278-0546 Screening compound: 6-methyl-2-(methylsulfanyl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-4-amine alternative view

Chemical Structure Depiction of ChemDiv screening compound D278-0546
6-methyl-2-(methylsulfanyl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-4-amine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

D278-0546

Molecular Formula

C16H20N4OS (C16 H20 N4 OS)

Compound Name

6-methyl-2-(methylsulfanyl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-4-amine

IUPAC name

6-methyl-2-(methylsulfanyl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-4-amine

SMILES

Cc1nc(SC)nc(Nc(cc2)ccc2N2CCOCC2)c1

InChI

InChI=1S/C16H20N4OS/c1-12-11-15(19-16(17-12)22-2)18-13-3-5-14(6-4-13)20-7-9-21-10-8-20/h3-6,11H,7-10H2,1-2H3,(H,17,18,19)

InChI Key

JIMIVJRMNMWSHW-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD10044472

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

316.43

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

3.262

Distribution Coefficient, logD

3.248

Water Solubility, LogSw

-3.30

Polar Surface Area

38.179

Acid Dissociation Constant (pKa)

18.00

Base Dissociation Constant (pKb)

5.92

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

37.50

D278-0546 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

CNS MPO Library (28609 compounds)

Akt-Targeted Library (14764 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with D278-0546 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound D278-0546?
Check Price and Availability of D278-0546, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of D278-0546 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for D278-0546
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for D278-0546
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of D278-0546 available by request