D282-0435 Screening compound: 2-(2-phenyl-1,3-thiazol-4-yl)-N-{4-[(pyridin-2-yl)sulfamoyl]phenyl}acetamide

D282-0435 Screening compound: 2-(2-phenyl-1,3-thiazol-4-yl)-N-{4-[(pyridin-2-yl)sulfamoyl]phenyl}acetamide
D282-0435 Screening compound: 2-(2-phenyl-1,3-thiazol-4-yl)-N-{4-[(pyridin-2-yl)sulfamoyl]phenyl}acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound D282-0435
2-(2-phenyl-1,3-thiazol-4-yl)-N-{4-[(pyridin-2-yl)sulfamoyl]phenyl}acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

D282-0435

Molecular Formula

C22H18N4O3S2 (C22 H18 N4 O3 S2)

Compound Name

2-(2-phenyl-1,3-thiazol-4-yl)-N-{4-[(pyridin-2-yl)sulfamoyl]phenyl}acetamide

IUPAC name

2-(2-phenyl-13-thiazol-4-yl)-N-{4-[(pyridin-2-yl)sulfamoyl]phenyl}acetamide

SMILES

O=C(Cc1csc(-c2ccccc2)n1)Nc(cc1)ccc1S(Nc1ncccc1)(=O)=O

InChI

InChI=1S/C22H18N4O3S2/c27-21(14-18-15-30-22(25-18)16-6-2-1-3-7-16)24-17-9-11-19(12-10-17)31(28,29)26-20-8-4-5-13-23-20/h1-13,15H,14H2,(H,23,26)(H,24,27)

InChI Key

OLKGDELBFHIBPM-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD08568277

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

450.54

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.847

Distribution Coefficient, logD

3.693

Water Solubility, LogSw

-4.16

Polar Surface Area

83.610

Acid Dissociation Constant (pKa)

7.77

Base Dissociation Constant (pKb)

0.97

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

4.50

D282-0435 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with D282-0435 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound D282-0435?
Check Price and Availability of D282-0435, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of D282-0435 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for D282-0435
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for D282-0435
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of D282-0435 available by request