D294-0365 Screening compound: N-{5-[1-(3,5-dimethylphenyl)-5-oxopyrrolidin-3-yl]-1,3,4-thiadiazol-2-yl}-2-methylbenzamide

D294-0365 Screening compound: N-{5-[1-(3,5-dimethylphenyl)-5-oxopyrrolidin-3-yl]-1,3,4-thiadiazol-2-yl}-2-methylbenzamide
D294-0365 Screening compound: N-{5-[1-(3,5-dimethylphenyl)-5-oxopyrrolidin-3-yl]-1,3,4-thiadiazol-2-yl}-2-methylbenzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound D294-0365
N-{5-[1-(3,5-dimethylphenyl)-5-oxopyrrolidin-3-yl]-1,3,4-thiadiazol-2-yl}-2-methylbenzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

D294-0365

Molecular Formula

C22H22N4O2S (C22 H22 N4 O2 S)

Compound Name

N-{5-[1-(3,5-dimethylphenyl)-5-oxopyrrolidin-3-yl]-1,3,4-thiadiazol-2-yl}-2-methylbenzamide

IUPAC name

N-{5-[1-(35-dimethylphenyl)-5-oxopyrrolidin-3-yl]-134-thiadiazol-2-yl}-2-methylbenzamide

SMILES

Cc1cc(N(CC(C2)c3nnc(NC(c4c(C)cccc4)=O)s3)C2=O)cc(C)c1

InChI

InChI=1S/C22H22N4O2S/c1-13-8-14(2)10-17(9-13)26-12-16(11-19(26)27)21-24-25-22(29-21)23-20(28)18-7-5-4-6-15(18)3/h4-10,16H,11-12H2,1-3H3,(H,23,25,28)/t16-/m0/s1

InChI Key

KUYRFPZXBYQJBU-INIZCTEOSA-N

MDL Number (MFCD)

MFCD09270530

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

406.51

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.376

Distribution Coefficient, logD

2.922

Water Solubility, LogSw

-4.32

Polar Surface Area

63.353

Acid Dissociation Constant (pKa)

5.96

Base Dissociation Constant (pKb)

-2.11

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

27.30

D294-0365 in Drug Discovery

Included in Screening Libraries

C-Met Library (15277 compounds)

Type II Kinase Inhibitors Library (6956 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
  • Digestive system
  • Hemic and lymphatic
  • Endocrine
Targets:
  • Kinases
  • Kinases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with D294-0365 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound D294-0365?
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What is the minimum amount of D294-0365 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for D294-0365
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for D294-0365
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of D294-0365 available by request