D358-0973 Screening compound: 6-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-3-(4-methylphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

D358-0973 Screening compound: 6-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-3-(4-methylphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
D358-0973 Screening compound: 6-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-3-(4-methylphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one alternative view

Chemical Structure Depiction of ChemDiv screening compound D358-0973
6-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-3-(4-methylphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

D358-0973

Molecular Formula

C26H26N4O2S (C26 H26 N4 O2 S)

Compound Name

6-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-3-(4-methylphenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

IUPAC name

6-[4-(23-dimethylphenyl)piperazine-1-carbonyl]-3-(4-methylphenyl)-5H-[13]thiazolo[32-a]pyrimidin-5-one

SMILES

Cc(cc1)ccc1C(N12)=CSC2=NC=C(C(N(CC2)CCN2c2c(C)c(C)ccc2)=O)C1=O

InChI

InChI=1S/C26H26N4O2S/c1-17-7-9-20(10-8-17)23-16-33-26-27-15-21(25(32)30(23)26)24(31)29-13-11-28(12-14-29)22-6-4-5-18(2)19(22)3/h4-10,15-16H,11-14H2,1-3H3

InChI Key

ZRNLMSROVYQIOM-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD09777628

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

458.58

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.528

Distribution Coefficient, logD

4.528

Water Solubility, LogSw

-4.21

Polar Surface Area

44.852

Acid Dissociation Constant (pKa)

28.43

Base Dissociation Constant (pKb)

2.74

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

26.90

D358-0973 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

Protein-Protein Interaction Library (218420 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with D358-0973 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound D358-0973?
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What is the minimum amount of D358-0973 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for D358-0973
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for D358-0973
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of D358-0973 available by request