D374-0121 Screening compound: 2-(4-bromophenoxy)-N-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)acetamide

D374-0121 Screening compound: 2-(4-bromophenoxy)-N-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)acetamide
D374-0121 Screening compound: 2-(4-bromophenoxy)-N-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound D374-0121
2-(4-bromophenoxy)-N-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

D374-0121

Molecular Formula

C16H13BrN2O4 (C16 H13 BrN2 O4)

Compound Name

2-(4-bromophenoxy)-N-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)acetamide

IUPAC name

2-(4-bromophenoxy)-N-(3-oxo-34-dihydro-2H-14-benzoxazin-6-yl)acetamide

SMILES

O=C(COc(cc1)ccc1Br)Nc(cc1)cc(N2)c1OCC2=O

InChI

InChI=1S/C16H13BrN2O4/c17-10-1-4-12(5-2-10)22-8-15(20)18-11-3-6-14-13(7-11)19-16(21)9-23-14/h1-7H,8-9H2,(H,18,20)(H,19,21)

InChI Key

PHLZDYXWVNEAHH-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD12914463

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

377.19

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

2.759

Distribution Coefficient, logD

2.759

Water Solubility, LogSw

-3.22

Polar Surface Area

63.886

Acid Dissociation Constant (pKa)

11.39

Base Dissociation Constant (pKb)

1.23

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

12.50

D374-0121 in Drug Discovery

Included in Screening Libraries

Anti-Aging Library (44940 compounds)

KRAS-Targeted Library (16000 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Metabolic
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Mechanism of action:
  • Epigenetic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with D374-0121 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound D374-0121?
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What is the minimum amount of D374-0121 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for D374-0121
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for D374-0121
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of D374-0121 available by request