D754-0238 Screening compound: 2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]-N~1~-[(2S)-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenylpropyl]acetamide

D754-0238 Screening compound: 2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]-N~1~-[(2S)-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenylpropyl]acetamide
D754-0238 Screening compound: 2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]-N~1~-[(2S)-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenylpropyl]acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound D754-0238
2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]-N~1~-[(2S)-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenylpropyl]acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

D754-0238

Molecular Formula

C28H24FN3O2S (C28 H24 FN3 O2 S)

Compound Name

2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]-N~1~-[(2S)-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenylpropyl]acetamide

IUPAC name

2-[2-(4-fluorophenyl)-13-thiazol-4-yl]-N-[(2S)-3-(1-oxo-23-dihydro-1H-isoindol-2-yl)-2-phenylpropyl]acetamide

SMILES

O=C(Cc1csc(-c(cc2)ccc2F)n1)NC[C@@H](CN(Cc1c2cccc1)C2=O)c1ccccc1

InChI

InChI=1S/C28H24FN3O2S/c29-23-12-10-20(11-13-23)27-31-24(18-35-27)14-26(33)30-15-22(19-6-2-1-3-7-19)17-32-16-21-8-4-5-9-25(21)28(32)34/h1-13,18,22H,14-17H2,(H,30,33)/t22-/m0/s1

InChI Key

FALRQFCOSLKNFP-QFIPXVFZSA-N

MDL Number (MFCD)

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

485.58

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

5.153

Distribution Coefficient, logD

5.153

Water Solubility, LogSw

-5.32

Polar Surface Area

51.314

Acid Dissociation Constant (pKa)

14.89

Base Dissociation Constant (pKb)

-0.37

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

17.86

D754-0238 in Drug Discovery

Included in Screening Libraries

Akt-Targeted Library (14764 compounds)

MCE-18 Trends in Medicinal Chemistry (51288 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Targets:
  • Kinases
  • Phosphatases

References: we are preparing a list of scientific research reports with D754-0238 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound D754-0238?
Check Price and Availability of D754-0238, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of D754-0238 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for D754-0238
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for D754-0238
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of D754-0238 available by request