E018-2127 Screening compound: 6-methoxy-3-[(4-methylphenyl)sulfanyl]-N-[(oxolan-2-yl)methyl]-1H-indole-2-carboxamide

E018-2127 Screening compound: 6-methoxy-3-[(4-methylphenyl)sulfanyl]-N-[(oxolan-2-yl)methyl]-1H-indole-2-carboxamide
E018-2127 Screening compound: 6-methoxy-3-[(4-methylphenyl)sulfanyl]-N-[(oxolan-2-yl)methyl]-1H-indole-2-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E018-2127
6-methoxy-3-[(4-methylphenyl)sulfanyl]-N-[(oxolan-2-yl)methyl]-1H-indole-2-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E018-2127

Molecular Formula

C22H24N2O3S (C22 H24 N2 O3 S)

Compound Name

6-methoxy-3-[(4-methylphenyl)sulfanyl]-N-[(oxolan-2-yl)methyl]-1H-indole-2-carboxamide

IUPAC name

6-methoxy-3-[(4-methylphenyl)sulfanyl]-N-[(oxolan-2-yl)methyl]-1H-indole-2-carboxamide

SMILES

Cc(cc1)ccc1Sc1c(C(NCC2OCCC2)=O)[nH]c2c1ccc(OC)c2

InChI

InChI=1S/C22H24N2O3S/c1-14-5-8-17(9-6-14)28-21-18-10-7-15(26-2)12-19(18)24-20(21)22(25)23-13-16-4-3-11-27-16/h5-10,12,16,24H,3-4,11,13H2,1-2H3,(H,23,25)/t16-/m1/s1

InChI Key

YJTNFZBIFSXLPM-MRXNPFEDSA-N

MDL Number (MFCD)

MFCD14839420

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

396.51

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

4.084

Distribution Coefficient, logD

4.084

Water Solubility, LogSw

-4.39

Polar Surface Area

50.698

Acid Dissociation Constant (pKa)

14.56

Base Dissociation Constant (pKb)

-2.21

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

31.80

E018-2127 in Drug Discovery

Included in Screening Libraries

Protein Arginine Methyltransferases Library (27925 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with E018-2127 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E018-2127?
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What is the minimum amount of E018-2127 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E018-2127
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E018-2127
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E018-2127 available by request