E143-0100 Screening compound: 4-[(4-fluorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one

E143-0100 Screening compound: 4-[(4-fluorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one
E143-0100 Screening compound: 4-[(4-fluorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one alternative view

Chemical Structure Depiction of ChemDiv screening compound E143-0100
4-[(4-fluorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E143-0100

Molecular Formula

C23H17FN4O3 (C23 H17 FN4 O3)

Compound Name

4-[(4-fluorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)-4H,5H-[1,2,4]triazolo[4,3-a]quinazolin-5-one

IUPAC name

4-[(4-fluorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)-4H5H-[124]triazolo[43-a]quinazolin-5-one

SMILES

COc1cccc(-c(n2-c3c4cccc3)nnc2N(Cc(cc2)ccc2F)C4=O)c1O

InChI

InChI=1S/C23H17FN4O3/c1-31-19-8-4-6-17(20(19)29)21-25-26-23-27(13-14-9-11-15(24)12-10-14)22(30)16-5-2-3-7-18(16)28(21)23/h2-12,29H,13H2,1H3

InChI Key

UEMIVHIOLJHHBE-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14842181

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

416.41

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.681

Distribution Coefficient, logD

3.494

Water Solubility, LogSw

-3.96

Polar Surface Area

61.840

Acid Dissociation Constant (pKa)

7.67

Base Dissociation Constant (pKb)

-2.39

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

8.70

E143-0100 in Drug Discovery

Included in Screening Libraries

Angiogenesis library (14822 compounds)

Antiparasite Library (23996 compounds)

Antiviral Library (67538 compounds)

Protein-Protein Interaction Library (218420 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Infections
  • Immune system
  • animal
  • Antiviral
  • Infections
  • Immune system
  • Immune system
Agro:
  • Agro
Mechanism of action:
  • PPI modulators
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E143-0100 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E143-0100?
Check Price and Availability of E143-0100, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E143-0100 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E143-0100
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E143-0100
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E143-0100 available by request