E146-0268 Screening compound: 4-benzyl-1-{4H-chromeno[3,4-d][1,2]oxazole-3-carbonyl}piperidine

E146-0268 Screening compound: 4-benzyl-1-{4H-chromeno[3,4-d][1,2]oxazole-3-carbonyl}piperidine
E146-0268 Screening compound: 4-benzyl-1-{4H-chromeno[3,4-d][1,2]oxazole-3-carbonyl}piperidine alternative view

Chemical Structure Depiction of ChemDiv screening compound E146-0268
4-benzyl-1-{4H-chromeno[3,4-d][1,2]oxazole-3-carbonyl}piperidine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E146-0268

Molecular Formula

C23H22N2O3 (C23 H22 N2 O3)

Compound Name

4-benzyl-1-{4H-chromeno[3,4-d][1,2]oxazole-3-carbonyl}piperidine

IUPAC name

4-benzyl-1-{4H-chromeno[34-d][12]oxazole-3-carbonyl}piperidine

SMILES

O=C(c1noc-2c1COc1c2cccc1)N1CCC(Cc2ccccc2)CC1

InChI

InChI=1S/C23H22N2O3/c26-23(25-12-10-17(11-13-25)14-16-6-2-1-3-7-16)21-19-15-27-20-9-5-4-8-18(20)22(19)28-24-21/h1-9,17H,10-15H2

InChI Key

NPLWSJYTVIIYQV-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14842530

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

374.44

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

4.490

Distribution Coefficient, logD

4.490

Water Solubility, LogSw

-4.65

Polar Surface Area

47.145

Acid Dissociation Constant (pKa)

19.32

Base Dissociation Constant (pKb)

-1.98

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

30.40

E146-0268 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

GPCR Targeted Library (31838 compounds)

Targeted Diversity Library (40567 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
Targets:
  • GPCR
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E146-0268 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E146-0268?
Check Price and Availability of E146-0268, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E146-0268 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E146-0268
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E146-0268
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E146-0268 available by request