E146-1136 Screening compound: 1-(2-fluorophenyl)-4-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carbonyl}piperazine

E146-1136 Screening compound: 1-(2-fluorophenyl)-4-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carbonyl}piperazine
E146-1136 Screening compound: 1-(2-fluorophenyl)-4-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carbonyl}piperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound E146-1136
1-(2-fluorophenyl)-4-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carbonyl}piperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E146-1136

Molecular Formula

C22H21FN4O2 (C22 H21 FN4 O2)

Compound Name

1-(2-fluorophenyl)-4-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carbonyl}piperazine

IUPAC name

1-(2-fluorophenyl)-4-{1-methyl-1H4H-chromeno[43-c]pyrazole-3-carbonyl}piperazine

SMILES

Cn1nc(C(N(CC2)CCN2c(cccc2)c2F)=O)c2c1-c(cccc1)c1OC2

InChI

InChI=1S/C22H21FN4O2/c1-25-21-15-6-2-5-9-19(15)29-14-16(21)20(24-25)22(28)27-12-10-26(11-13-27)18-8-4-3-7-17(18)23/h2-9H,10-14H2,1H3

InChI Key

AMSCJCVRONULEE-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14842916

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

392.43

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

2.855

Distribution Coefficient, logD

2.855

Water Solubility, LogSw

-3.61

Polar Surface Area

42.618

Acid Dissociation Constant (pKa)

19.18

Base Dissociation Constant (pKb)

1.36

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

27.30

E146-1136 in Drug Discovery

Included in Screening Libraries

Protein-Protein Interaction Library (218420 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • Receptor's ligands
Therapeutical areas:
  • Immune system

References: we are preparing a list of scientific research reports with E146-1136 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E146-1136?
Check Price and Availability of E146-1136, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E146-1136 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E146-1136
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E146-1136
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E146-1136 available by request