E146-1172 Screening compound: 1-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carbonyl}-4-(pyridin-2-yl)piperazine

E146-1172 Screening compound: 1-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carbonyl}-4-(pyridin-2-yl)piperazine
E146-1172 Screening compound: 1-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carbonyl}-4-(pyridin-2-yl)piperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound E146-1172
1-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carbonyl}-4-(pyridin-2-yl)piperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E146-1172

Molecular Formula

C21H21N5O2 (C21 H21 N5 O2)

Compound Name

1-{1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carbonyl}-4-(pyridin-2-yl)piperazine

IUPAC name

1-{1-methyl-1H4H-chromeno[43-c]pyrazole-3-carbonyl}-4-(pyridin-2-yl)piperazine

SMILES

Cn1nc(C(N(CC2)CCN2c2ncccc2)=O)c2c1-c(cccc1)c1OC2

InChI

InChI=1S/C21H21N5O2/c1-24-20-15-6-2-3-7-17(15)28-14-16(20)19(23-24)21(27)26-12-10-25(11-13-26)18-8-4-5-9-22-18/h2-9H,10-14H2,1H3

InChI Key

ZJLIZEPWMMKZAZ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14842945

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

375.43

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

2.344

Distribution Coefficient, logD

2.336

Water Solubility, LogSw

-2.71

Polar Surface Area

51.431

Acid Dissociation Constant (pKa)

19.18

Base Dissociation Constant (pKb)

5.71

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

28.60

E146-1172 in Drug Discovery

Included in Screening Libraries

GPCR Targeted Library (31838 compounds)

Protein-Protein Interaction Library (218420 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Immune system
Targets:
  • GPCR
Mechanism of action:
  • Receptor's ligands
  • PPI modulators
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E146-1172 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E146-1172?
Check Price and Availability of E146-1172, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E146-1172 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E146-1172
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E146-1172
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E146-1172 available by request