E146-1389 Screening compound: N-[2-(adamantan-1-yloxy)ethyl]-1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carboxamide

E146-1389 Screening compound: N-[2-(adamantan-1-yloxy)ethyl]-1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carboxamide
E146-1389 Screening compound: N-[2-(adamantan-1-yloxy)ethyl]-1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E146-1389
N-[2-(adamantan-1-yloxy)ethyl]-1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E146-1389

Molecular Formula

C24H29N3O3 (C24 H29 N3 O3)

Compound Name

N-[2-(adamantan-1-yloxy)ethyl]-1-methyl-1H,4H-chromeno[4,3-c]pyrazole-3-carboxamide

IUPAC name

N-[2-(adamantan-1-yloxy)ethyl]-1-methyl-1H4H-chromeno[43-c]pyrazole-3-carboxamide

SMILES

Cn1nc(C(NCCOC2(CC(C3)C4)CC4CC3C2)=O)c2c1-c(cccc1)c1OC2

InChI

InChI=1S/C24H29N3O3/c1-27-22-18-4-2-3-5-20(18)29-14-19(22)21(26-27)23(28)25-6-7-30-24-11-15-8-16(12-24)10-17(9-15)13-24/h2-5,15-17H,6-14H2,1H3,(H,25,28)

InChI Key

QQLYMQXPJBFNOQ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14843119

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

407.51

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.906

Distribution Coefficient, logD

3.906

Water Solubility, LogSw

-4.20

Polar Surface Area

53.526

Acid Dissociation Constant (pKa)

13.73

Base Dissociation Constant (pKb)

-1.51

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

58.30

E146-1389 in Drug Discovery

Included in Screening Libraries

GPCR Targeted Library (31838 compounds)

Regenerative Medicine Focused Library (23016 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Musculoskeletal
  • Digestive system
  • Hemic and lymphatic
  • Cardiovascular
  • Skin
  • wounds
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Targets:
  • GPCR
  • Phosphatases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E146-1389 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E146-1389?
Check Price and Availability of E146-1389, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E146-1389 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E146-1389
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E146-1389
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E146-1389 available by request