E146-1677 Screening compound: N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-1-methyl-1H,4H-thiochromeno[4,3-c]pyrazole-3-carboxamide

E146-1677 Screening compound: N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-1-methyl-1H,4H-thiochromeno[4,3-c]pyrazole-3-carboxamide
E146-1677 Screening compound: N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-1-methyl-1H,4H-thiochromeno[4,3-c]pyrazole-3-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E146-1677
N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-1-methyl-1H,4H-thiochromeno[4,3-c]pyrazole-3-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E146-1677

Molecular Formula

C22H30N4OS (C22 H30 N4 OS)

Compound Name

N-[3-(2,6-dimethylpiperidin-1-yl)propyl]-1-methyl-1H,4H-thiochromeno[4,3-c]pyrazole-3-carboxamide

IUPAC name

N-[3-(26-dimethylpiperidin-1-yl)propyl]-1-methyl-1H4H-thiochromeno[43-c]pyrazole-3-carboxamide

SMILES

CC1N(CCCNC(c2nn(C)c-3c2CSc2c3cccc2)=O)C(C)CCC1

InChI

InChI=1S/C22H30N4OS/c1-15-8-6-9-16(2)26(15)13-7-12-23-22(27)20-18-14-28-19-11-5-4-10-17(19)21(18)25(3)24-20/h4-5,10-11,15-16H,6-9,12-14H2,1-3H3,(H,23,27)

InChI Key

NNUUXVLGCLCFMP-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14843322

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

398.57

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

2.872

Distribution Coefficient, logD

-0.229

Water Solubility, LogSw

-3.55

Polar Surface Area

41.354

Acid Dissociation Constant (pKa)

14.79

Base Dissociation Constant (pKb)

10.50

Number of Chiral Centers

2.00

Percent sp3 carbon bonding

54.50

E146-1677 in Drug Discovery

Included in Screening Libraries

Antiviral Annotated Library (21441 compounds)

CNS targets activity set (6557 compounds)

Human Kinases Annotated Library (2415 compounds)

Protein-Protein Interaction Library (218420 compounds)

Selective Target Activity Profiling Library (14702 compounds)

ChemoGenomic Annotated Library for Phenotypic Screening (89798 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • Receptor's ligands
Therapeutical areas:
  • Immune system

References: we are preparing a list of scientific research reports with E146-1677 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E146-1677?
Check Price and Availability of E146-1677, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E146-1677 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E146-1677
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E146-1677
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E146-1677 available by request