E153-0457 Screening compound: N-(2-methyl-5-{[1,3]thiazolo[5,4-b]pyridin-2-yl}phenyl)-2,2-diphenylacetamide

E153-0457 Screening compound: N-(2-methyl-5-{[1,3]thiazolo[5,4-b]pyridin-2-yl}phenyl)-2,2-diphenylacetamide
E153-0457 Screening compound: N-(2-methyl-5-{[1,3]thiazolo[5,4-b]pyridin-2-yl}phenyl)-2,2-diphenylacetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E153-0457
N-(2-methyl-5-{[1,3]thiazolo[5,4-b]pyridin-2-yl}phenyl)-2,2-diphenylacetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E153-0457

Molecular Formula

C27H21N3OS (C27 H21 N3 OS)

Compound Name

N-(2-methyl-5-{[1,3]thiazolo[5,4-b]pyridin-2-yl}phenyl)-2,2-diphenylacetamide

IUPAC name

N-(2-methyl-5-{[13]thiazolo[54-b]pyridin-2-yl}phenyl)-22-diphenylacetamide

SMILES

Cc(ccc(-c1nc2cccnc2s1)c1)c1NC(C(c1ccccc1)c1ccccc1)=O

InChI

InChI=1S/C27H21N3OS/c1-18-14-15-21(26-30-22-13-8-16-28-27(22)32-26)17-23(18)29-25(31)24(19-9-4-2-5-10-19)20-11-6-3-7-12-20/h2-17,24H,1H3,(H,29,31)

InChI Key

FNBWCKHFBSBTAK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD05894496

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

435.55

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

6.113

Distribution Coefficient, logD

6.113

Water Solubility, LogSw

-5.52

Polar Surface Area

41.215

Acid Dissociation Constant (pKa)

11.48

Base Dissociation Constant (pKb)

2.55

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

7.40

E153-0457 in Drug Discovery

Included in Screening Libraries

DGK Inhibitors Library (10558 compounds)

Akt-Targeted Library (14764 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Hemic and lymphatic
  • Skin
  • Metabolic
  • Immune system
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases
  • Kinases

References: we are preparing a list of scientific research reports with E153-0457 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E153-0457?
Check Price and Availability of E153-0457, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E153-0457 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E153-0457
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E153-0457
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E153-0457 available by request