E157-2770 Screening compound: 4-ethoxy-N-{5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]-1,3,4-thiadiazol-2-yl}benzamide

E157-2770 Screening compound: 4-ethoxy-N-{5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]-1,3,4-thiadiazol-2-yl}benzamide
E157-2770 Screening compound: 4-ethoxy-N-{5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]-1,3,4-thiadiazol-2-yl}benzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E157-2770
4-ethoxy-N-{5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]-1,3,4-thiadiazol-2-yl}benzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E157-2770

Molecular Formula

C20H20N4O4S2 (C20 H20 N4 O4 S2)

Compound Name

4-ethoxy-N-{5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]-1,3,4-thiadiazol-2-yl}benzamide

IUPAC name

4-ethoxy-N-{5-[(2-methyl-23-dihydro-1H-indol-1-yl)sulfonyl]-134-thiadiazol-2-yl}benzamide

SMILES

CCOc(cc1)ccc1C(Nc(s1)nnc1S(N(C(C)C1)c2c1cccc2)(=O)=O)=O

InChI

InChI=1S/C20H20N4O4S2/c1-3-28-16-10-8-14(9-11-16)18(25)21-19-22-23-20(29-19)30(26,27)24-13(2)12-15-6-4-5-7-17(15)24/h4-11,13H,3,12H2,1-2H3,(H,21,22,25)/t13-/m0/s1

InChI Key

HSXXYVZSZOTIJU-ZDUSSCGKSA-N

MDL Number (MFCD)

MFCD14843671

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

444.54

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

4.392

Distribution Coefficient, logD

3.295

Water Solubility, LogSw

-4.11

Polar Surface Area

85.007

Acid Dissociation Constant (pKa)

6.34

Base Dissociation Constant (pKb)

-8.70

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

25.00

E157-2770 in Drug Discovery

Included in Screening Libraries

Allosteric Kinases Inhibitors Library (23117 compounds)

Antimitotic Tubulin Library (17355 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Female
  • Congenital
  • Skin
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with E157-2770 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E157-2770?
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What is the minimum amount of E157-2770 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E157-2770
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E157-2770
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E157-2770 available by request