E233-1870 Screening compound: 4-{2-[(3-chlorophenyl)methyl]-8-methyl-2H,4H,5H-furo[2,3-g]indazole-7-carbonyl}morpholine

E233-1870 Screening compound: 4-{2-[(3-chlorophenyl)methyl]-8-methyl-2H,4H,5H-furo[2,3-g]indazole-7-carbonyl}morpholine
E233-1870 Screening compound: 4-{2-[(3-chlorophenyl)methyl]-8-methyl-2H,4H,5H-furo[2,3-g]indazole-7-carbonyl}morpholine alternative view

Chemical Structure Depiction of ChemDiv screening compound E233-1870
4-{2-[(3-chlorophenyl)methyl]-8-methyl-2H,4H,5H-furo[2,3-g]indazole-7-carbonyl}morpholine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E233-1870

Molecular Formula

C22H22ClN3O3 (C22 H22 ClN3 O3)

Compound Name

4-{2-[(3-chlorophenyl)methyl]-8-methyl-2H,4H,5H-furo[2,3-g]indazole-7-carbonyl}morpholine

IUPAC name

4-{2-[(3-chlorophenyl)methyl]-8-methyl-2H4H5H-furo[23-g]indazole-7-carbonyl}morpholine

SMILES

Cc1c(C(N2CCOCC2)=O)oc2c1-c1nn(Cc3cccc(Cl)c3)cc1CC2

InChI

InChI=1S/C22H22ClN3O3/c1-14-19-18(29-21(14)22(27)25-7-9-28-10-8-25)6-5-16-13-26(24-20(16)19)12-15-3-2-4-17(23)11-15/h2-4,11,13H,5-10,12H2,1H3

InChI Key

PLHLTOCYMNCVFE-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14850693

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

411.89

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.326

Distribution Coefficient, logD

3.326

Water Solubility, LogSw

-3.89

Polar Surface Area

48.393

Acid Dissociation Constant (pKa)

21.84

Base Dissociation Constant (pKb)

-0.96

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

36.40

E233-1870 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

KRAS-Targeted Library (16000 compounds)

Protein-Protein Interaction Library (218420 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Immune system
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E233-1870 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E233-1870?
Check Price and Availability of E233-1870, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E233-1870 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E233-1870
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E233-1870
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E233-1870 available by request