E677-1346 Screening compound: N-[3-(dimethylamino)propyl]-N-(4-fluoro-1,3-benzothiazol-2-yl)-2,2-diphenylacetamide

E677-1346 Screening compound: N-[3-(dimethylamino)propyl]-N-(4-fluoro-1,3-benzothiazol-2-yl)-2,2-diphenylacetamide
E677-1346 Screening compound: N-[3-(dimethylamino)propyl]-N-(4-fluoro-1,3-benzothiazol-2-yl)-2,2-diphenylacetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E677-1346
N-[3-(dimethylamino)propyl]-N-(4-fluoro-1,3-benzothiazol-2-yl)-2,2-diphenylacetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E677-1346

Molecular Formula

C26H26FN3OS (C26 H26 FN3 OS)

Compound Name

N-[3-(dimethylamino)propyl]-N-(4-fluoro-1,3-benzothiazol-2-yl)-2,2-diphenylacetamide

IUPAC name

N-[3-(dimethylamino)propyl]-N-(4-fluoro-13-benzothiazol-2-yl)-22-diphenylacetamide

SMILES

CN(C)CCCN(C(C(c1ccccc1)c1ccccc1)=O)c1nc(c(F)ccc2)c2s1

InChI

InChI=1S/C26H26FN3OS/c1-29(2)17-10-18-30(26-28-24-21(27)15-9-16-22(24)32-26)25(31)23(19-11-5-3-6-12-19)20-13-7-4-8-14-20/h3-9,11-16,23H,10,17-18H2,1-2H3

InChI Key

OFXBQXFGVNZGIU-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD09972676

Chemical and Physical Properties

Saltdata

HCl

Molecular Weight

447.58

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

5.561

Distribution Coefficient, logD

3.356

Water Solubility, LogSw

-5.37

Polar Surface Area

29.739

Acid Dissociation Constant (pKa)

15.53

Base Dissociation Constant (pKb)

9.60

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

23.10

E677-1346 in Drug Discovery

Included in Screening Libraries

CNS Targets (44014 compounds)

DGK Inhibitors Library (10558 compounds)

Protein Arginine Methyltransferases Library (27925 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Cancer
  • Digestive system
  • Hemic and lymphatic
  • Skin
  • Metabolic
  • Immune system
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Kinases
  • Others
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with E677-1346 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E677-1346?
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What is the minimum amount of E677-1346 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E677-1346
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E677-1346
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E677-1346 available by request