E746-0446 Screening compound: N-cyclohexyl-2-[3-oxo-6-(phenylsulfamoyl)-3,4-dihydro-2H-1,4-benzoxazin-4-yl]acetamide

E746-0446 Screening compound: N-cyclohexyl-2-[3-oxo-6-(phenylsulfamoyl)-3,4-dihydro-2H-1,4-benzoxazin-4-yl]acetamide
E746-0446 Screening compound: N-cyclohexyl-2-[3-oxo-6-(phenylsulfamoyl)-3,4-dihydro-2H-1,4-benzoxazin-4-yl]acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E746-0446
N-cyclohexyl-2-[3-oxo-6-(phenylsulfamoyl)-3,4-dihydro-2H-1,4-benzoxazin-4-yl]acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E746-0446

Molecular Formula

C22H25N3O5S (C22 H25 N3 O5 S)

Compound Name

N-cyclohexyl-2-[3-oxo-6-(phenylsulfamoyl)-3,4-dihydro-2H-1,4-benzoxazin-4-yl]acetamide

IUPAC name

N-cyclohexyl-2-[3-oxo-6-(phenylsulfamoyl)-34-dihydro-2H-14-benzoxazin-4-yl]acetamide

SMILES

O=C(CN1c(cc(cc2)S(Nc3ccccc3)(=O)=O)c2OCC1=O)NC1CCCCC1

MDL Number (MFCD)

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

443.52

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

2.765

Distribution Coefficient, logD

2.762

Water Solubility, LogSw

-3.49

Polar Surface Area

88.915

Acid Dissociation Constant (pKa)

9.64

Base Dissociation Constant (pKb)

1.69

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

36.40

E746-0446 in Drug Discovery

Included in Screening Libraries

GPCR Targeted Library (31838 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
Targets:
  • GPCR
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E746-0446 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E746-0446?
Check Price and Availability of E746-0446, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E746-0446 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E746-0446
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E746-0446
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E746-0446 available by request