E756-0273 Screening compound: 1-{5-fluoro-1-methyl-2-[3-methyl-4-(3-methylphenyl)piperazine-1-carbonyl]-1H-indol-3-yl}pyrrolidin-2-one

E756-0273 Screening compound: 1-{5-fluoro-1-methyl-2-[3-methyl-4-(3-methylphenyl)piperazine-1-carbonyl]-1H-indol-3-yl}pyrrolidin-2-one
E756-0273 Screening compound: 1-{5-fluoro-1-methyl-2-[3-methyl-4-(3-methylphenyl)piperazine-1-carbonyl]-1H-indol-3-yl}pyrrolidin-2-one alternative view

Chemical Structure Depiction of ChemDiv screening compound E756-0273
1-{5-fluoro-1-methyl-2-[3-methyl-4-(3-methylphenyl)piperazine-1-carbonyl]-1H-indol-3-yl}pyrrolidin-2-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E756-0273

Molecular Formula

C26H29FN4O2 (C26 H29 FN4 O2)

Compound Name

1-{5-fluoro-1-methyl-2-[3-methyl-4-(3-methylphenyl)piperazine-1-carbonyl]-1H-indol-3-yl}pyrrolidin-2-one

IUPAC name

1-{5-fluoro-1-methyl-2-[3-methyl-4-(3-methylphenyl)piperazine-1-carbonyl]-1H-indol-3-yl}pyrrolidin-2-one

SMILES

CC(CN(CC1)C(c(n(C)c(cc2)c3cc2F)c3N(CCC2)C2=O)=O)N1c1cc(C)ccc1

InChI

InChI=1S/C26H29FN4O2/c1-17-6-4-7-20(14-17)30-13-12-29(16-18(30)2)26(33)25-24(31-11-5-8-23(31)32)21-15-19(27)9-10-22(21)28(25)3/h4,6-7,9-10,14-15,18H,5,8,11-13,16H2,1-3H3/t18-/m0/s1

InChI Key

YONISIVHBRNFBA-SFHVURJKSA-N

MDL Number (MFCD)

MFCD14916130

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

448.54

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.219

Distribution Coefficient, logD

4.219

Water Solubility, LogSw

-4.36

Polar Surface Area

36.892

Acid Dissociation Constant (pKa)

14.51

Base Dissociation Constant (pKb)

6.89

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

38.50

E756-0273 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Anti-HIV1 Library (19540 compounds)

Aurora A-B Kinases Targeted Library (9426 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Antiviral
  • Infections
  • Immune system
  • Cancer
  • Digestive system
  • Male
  • Female
  • Hemic and lymphatic
Targets:
  • Kinases
  • Kinases

References: we are preparing a list of scientific research reports with E756-0273 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E756-0273?
Check Price and Availability of E756-0273, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E756-0273 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E756-0273
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E756-0273
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E756-0273 available by request