E760-1236 Screening compound: 8-(4-{2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl}benzoyl)-1,4-dioxa-8-azaspiro[4.5]decane

E760-1236 Screening compound: 8-(4-{2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl}benzoyl)-1,4-dioxa-8-azaspiro[4.5]decane
E760-1236 Screening compound: 8-(4-{2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl}benzoyl)-1,4-dioxa-8-azaspiro[4.5]decane alternative view

Chemical Structure Depiction of ChemDiv screening compound E760-1236
8-(4-{2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl}benzoyl)-1,4-dioxa-8-azaspiro[4.5]decane

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E760-1236

Molecular Formula

C26H24N4O3 (C26 H24 N4 O3)

Compound Name

8-(4-{2-phenyl-3H-imidazo[4,5-b]pyridin-3-yl}benzoyl)-1,4-dioxa-8-azaspiro[4.5]decane

IUPAC name

8-(4-{2-phenyl-3H-imidazo[45-b]pyridin-3-yl}benzoyl)-14-dioxa-8-azaspiro[4.5]decane

SMILES

O=C(c(cc1)ccc1-n1c(-c2ccccc2)nc2cccnc12)N(CC1)CCC11OCCO1

InChI

InChI=1S/C26H24N4O3/c31-25(29-15-12-26(13-16-29)32-17-18-33-26)20-8-10-21(11-9-20)30-23(19-5-2-1-3-6-19)28-22-7-4-14-27-24(22)30/h1-11,14H,12-13,15-18H2

InChI Key

UCRHZUZCZBTMAN-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14916603

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

440.5

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.103

Distribution Coefficient, logD

3.103

Water Solubility, LogSw

-3.20

Polar Surface Area

51.631

Acid Dissociation Constant (pKa)

27.30

Base Dissociation Constant (pKb)

4.03

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

26.90

E760-1236 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

CNS Targets (44014 compounds)

PI3K-Targeted Library (17255 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with E760-1236 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E760-1236?
Check Price and Availability of E760-1236, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E760-1236 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E760-1236
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E760-1236
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E760-1236 available by request