E848-1486 Screening compound: N-{[4-(dimethylamino)phenyl]methyl}-3-{5-[(4-methylpiperidin-1-yl)sulfonyl]-1H-indol-1-yl}propanamide

E848-1486 Screening compound: N-{[4-(dimethylamino)phenyl]methyl}-3-{5-[(4-methylpiperidin-1-yl)sulfonyl]-1H-indol-1-yl}propanamide
E848-1486 Screening compound: N-{[4-(dimethylamino)phenyl]methyl}-3-{5-[(4-methylpiperidin-1-yl)sulfonyl]-1H-indol-1-yl}propanamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E848-1486
N-{[4-(dimethylamino)phenyl]methyl}-3-{5-[(4-methylpiperidin-1-yl)sulfonyl]-1H-indol-1-yl}propanamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E848-1486

Molecular Formula

C26H34N4O3S (C26 H34 N4 O3 S)

Compound Name

N-{[4-(dimethylamino)phenyl]methyl}-3-{5-[(4-methylpiperidin-1-yl)sulfonyl]-1H-indol-1-yl}propanamide

IUPAC name

N-{[4-(dimethylamino)phenyl]methyl}-3-{5-[(4-methylpiperidin-1-yl)sulfonyl]-1H-indol-1-yl}propanamide

SMILES

CC(CC1)CCN1S(c(cc1)cc2c1n(CCC(NCc(cc1)ccc1N(C)C)=O)cc2)(=O)=O

InChI

InChI=1S/C26H34N4O3S/c1-20-10-16-30(17-11-20)34(32,33)24-8-9-25-22(18-24)12-14-29(25)15-13-26(31)27-19-21-4-6-23(7-5-21)28(2)3/h4-9,12,14,18,20H,10-11,13,15-17,19H2,1-3H3,(H,27,31)

InChI Key

SVVSDYZNLJHRCQ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14921343

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

482.65

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.030

Distribution Coefficient, logD

4.014

Water Solubility, LogSw

-3.99

Polar Surface Area

61.043

Acid Dissociation Constant (pKa)

13.40

Base Dissociation Constant (pKb)

5.96

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

42.30

E848-1486 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Lipid Metabolism Library (9174 compounds)

MCL1 Targeted Library (12200 compounds)

ChemoGenomic Annotated Library for Phenotypic Screening (89798 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cardiovascular
  • Metabolic
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic

References: we are preparing a list of scientific research reports with E848-1486 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E848-1486?
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What is the minimum amount of E848-1486 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E848-1486
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E848-1486
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E848-1486 available by request