E912-0186 Screening compound: N-(3-bromophenyl)-5-(6-oxo-1,6-dihydropyridazin-3-yl)thiophene-2-sulfonamide

E912-0186 Screening compound: N-(3-bromophenyl)-5-(6-oxo-1,6-dihydropyridazin-3-yl)thiophene-2-sulfonamide
E912-0186 Screening compound: N-(3-bromophenyl)-5-(6-oxo-1,6-dihydropyridazin-3-yl)thiophene-2-sulfonamide alternative view

Chemical Structure Depiction of ChemDiv screening compound E912-0186
N-(3-bromophenyl)-5-(6-oxo-1,6-dihydropyridazin-3-yl)thiophene-2-sulfonamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E912-0186

Molecular Formula

C14H10BrN3O3S2 (C14 H10 BrN3 O3 S2)

Compound Name

N-(3-bromophenyl)-5-(6-oxo-1,6-dihydropyridazin-3-yl)thiophene-2-sulfonamide

IUPAC name

N-(3-bromophenyl)-5-(6-oxo-16-dihydropyridazin-3-yl)thiophene-2-sulfonamide

SMILES

O=C(C=C1)NN=C1c(s1)ccc1S(Nc1cccc(Br)c1)(=O)=O

InChI

InChI=1S/C14H10BrN3O3S2/c15-9-2-1-3-10(8-9)18-23(20,21)14-7-5-12(22-14)11-4-6-13(19)17-16-11/h1-8,18H,(H,17,19)

InChI Key

YVFVPRHRFKMILP-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14927295

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

412.29

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.854

Distribution Coefficient, logD

3.689

Water Solubility, LogSw

-4.06

Polar Surface Area

79.044

Acid Dissociation Constant (pKa)

7.74

Base Dissociation Constant (pKb)

-1.15

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

0.00

E912-0186 in Drug Discovery

Included in Screening Libraries

Angiogenesis library (14822 compounds)

KRAS-Targeted Library (16000 compounds)

NOTUM (Wnt signaling) Library (3881 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with E912-0186 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E912-0186?
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What is the minimum amount of E912-0186 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E912-0186
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E912-0186
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E912-0186 available by request