E922-1445 Screening compound: 1-(4-chlorophenyl)-4-[1-(2-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazine

E922-1445 Screening compound: 1-(4-chlorophenyl)-4-[1-(2-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazine
E922-1445 Screening compound: 1-(4-chlorophenyl)-4-[1-(2-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound E922-1445
1-(4-chlorophenyl)-4-[1-(2-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E922-1445

Molecular Formula

C25H27Cl2N5O (C25 H27 Cl2 N5 O)

Compound Name

1-(4-chlorophenyl)-4-[1-(2-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazine

IUPAC name

1-(4-chlorophenyl)-4-[1-(2-chlorophenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]piperazine

SMILES

O=C(c1c(C2CCNCC2)n(-c(cccc2)c2Cl)nc1)N(CC1)CCN1c(cc1)ccc1Cl

InChI

InChI=1S/C25H27Cl2N5O/c26-19-5-7-20(8-6-19)30-13-15-31(16-14-30)25(33)21-17-29-32(23-4-2-1-3-22(23)27)24(21)18-9-11-28-12-10-18/h1-8,17-18,28H,9-16H2

InChI Key

WDGBUNOUXZXDCB-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14928550

Chemical and Physical Properties

Saltdata

HCl

Molecular Weight

484.43

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.567

Distribution Coefficient, logD

0.086

Water Solubility, LogSw

-3.94

Polar Surface Area

44.822

Acid Dissociation Constant (pKa)

21.79

Base Dissociation Constant (pKb)

10.88

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

36.00

E922-1445 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with E922-1445 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E922-1445?
Check Price and Availability of E922-1445, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E922-1445 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E922-1445
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E922-1445
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E922-1445 available by request