E922-2178 Screening compound: 1-[1-(3-chloro-2-methylphenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]-4-(2,4-dimethylphenyl)piperazine

E922-2178 Screening compound: 1-[1-(3-chloro-2-methylphenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]-4-(2,4-dimethylphenyl)piperazine
E922-2178 Screening compound: 1-[1-(3-chloro-2-methylphenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]-4-(2,4-dimethylphenyl)piperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound E922-2178
1-[1-(3-chloro-2-methylphenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]-4-(2,4-dimethylphenyl)piperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E922-2178

Molecular Formula

C28H34ClN5O (C28 H34 ClN5 O)

Compound Name

1-[1-(3-chloro-2-methylphenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]-4-(2,4-dimethylphenyl)piperazine

IUPAC name

1-[1-(3-chloro-2-methylphenyl)-5-(piperidin-4-yl)-1H-pyrazole-4-carbonyl]-4-(24-dimethylphenyl)piperazine

SMILES

Cc(cc1)cc(C)c1N(CC1)CCN1C(c1c(C2CCNCC2)n(-c2cccc(Cl)c2C)nc1)=O

InChI

InChI=1S/C28H34ClN5O/c1-19-7-8-25(20(2)17-19)32-13-15-33(16-14-32)28(35)23-18-31-34(26-6-4-5-24(29)21(26)3)27(23)22-9-11-30-12-10-22/h4-8,17-18,22,30H,9-16H2,1-3H3

InChI Key

XTYCHYKQOZFMBH-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14928706

Chemical and Physical Properties

Saltdata

HCl

Molecular Weight

492.06

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.804

Distribution Coefficient, logD

1.323

Water Solubility, LogSw

-4.79

Polar Surface Area

44.521

Acid Dissociation Constant (pKa)

21.63

Base Dissociation Constant (pKb)

10.88

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

42.90

E922-2178 in Drug Discovery

Included in Screening Libraries

Serine Proteases Inhibitors Library (32732 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Targets:
  • Proteases

References: we are preparing a list of scientific research reports with E922-2178 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E922-2178?
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What is the minimum amount of E922-2178 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E922-2178
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E922-2178
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E922-2178 available by request