E947-0158 Screening compound: 5-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-3,6-dimethyl-3H,4H-furo[2,3-d]pyrimidin-4-one

E947-0158 Screening compound: 5-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-3,6-dimethyl-3H,4H-furo[2,3-d]pyrimidin-4-one
E947-0158 Screening compound: 5-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-3,6-dimethyl-3H,4H-furo[2,3-d]pyrimidin-4-one alternative view

Chemical Structure Depiction of ChemDiv screening compound E947-0158
5-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-3,6-dimethyl-3H,4H-furo[2,3-d]pyrimidin-4-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E947-0158

Molecular Formula

C21H24N4O3 (C21 H24 N4 O3)

Compound Name

5-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-3,6-dimethyl-3H,4H-furo[2,3-d]pyrimidin-4-one

IUPAC name

5-[4-(25-dimethylphenyl)piperazine-1-carbonyl]-36-dimethyl-3H4H-furo[23-d]pyrimidin-4-one

SMILES

Cc1c(C(N(CC2)CCN2c2c(C)ccc(C)c2)=O)c(C(N(C)C=N2)=O)c2o1

InChI

InChI=1S/C21H24N4O3/c1-13-5-6-14(2)16(11-13)24-7-9-25(10-8-24)21(27)17-15(3)28-19-18(17)20(26)23(4)12-22-19/h5-6,11-12H,7-10H2,1-4H3

InChI Key

UGMMYGOEVMGEEV-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27093670

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

380.45

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

2.126

Distribution Coefficient, logD

2.126

Water Solubility, LogSw

-2.59

Polar Surface Area

53.316

Acid Dissociation Constant (pKa)

28.39

Base Dissociation Constant (pKb)

4.79

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

38.10

E947-0158 in Drug Discovery

Included in Screening Libraries

PI3K-Targeted Library (17255 compounds)

Adenosine Receptors Targeted Library (19896 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Cancer
  • Digestive system
  • Respiratory tract
  • Nervous system
  • Eye
  • Cardiovascular
Targets:
  • Kinases
  • GPCR
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E947-0158 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E947-0158?
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What is the minimum amount of E947-0158 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E947-0158
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E947-0158
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E947-0158 available by request