E947-0493 Screening compound: 6-methyl-3-(2-methylpropyl)-5-[4-(pyridin-2-yl)piperazine-1-carbonyl]-3H,4H-furo[2,3-d]pyrimidin-4-one

E947-0493 Screening compound: 6-methyl-3-(2-methylpropyl)-5-[4-(pyridin-2-yl)piperazine-1-carbonyl]-3H,4H-furo[2,3-d]pyrimidin-4-one
E947-0493 Screening compound: 6-methyl-3-(2-methylpropyl)-5-[4-(pyridin-2-yl)piperazine-1-carbonyl]-3H,4H-furo[2,3-d]pyrimidin-4-one alternative view

Chemical Structure Depiction of ChemDiv screening compound E947-0493
6-methyl-3-(2-methylpropyl)-5-[4-(pyridin-2-yl)piperazine-1-carbonyl]-3H,4H-furo[2,3-d]pyrimidin-4-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E947-0493

Molecular Formula

C21H25N5O3 (C21 H25 N5 O3)

Compound Name

6-methyl-3-(2-methylpropyl)-5-[4-(pyridin-2-yl)piperazine-1-carbonyl]-3H,4H-furo[2,3-d]pyrimidin-4-one

IUPAC name

6-methyl-3-(2-methylpropyl)-5-[4-(pyridin-2-yl)piperazine-1-carbonyl]-3H4H-furo[23-d]pyrimidin-4-one

SMILES

CC(C)CN(C=Nc1c2c(C(N(CC3)CCN3c3ncccc3)=O)c(C)o1)C2=O

InChI

InChI=1S/C21H25N5O3/c1-14(2)12-26-13-23-19-18(21(26)28)17(15(3)29-19)20(27)25-10-8-24(9-11-25)16-6-4-5-7-22-16/h4-7,13-14H,8-12H2,1-3H3

InChI Key

UXQOHOZVVFYHJF-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27093867

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

395.46

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

2.187

Distribution Coefficient, logD

2.178

Water Solubility, LogSw

-2.22

Polar Surface Area

62.413

Acid Dissociation Constant (pKa)

24.69

Base Dissociation Constant (pKb)

5.71

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

42.90

E947-0493 in Drug Discovery

Included in Screening Libraries

PI3K-Targeted Library (17255 compounds)

SmartTM Library (51161 compounds)

Adenosine Receptors Targeted Library (19896 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Cancer
  • Digestive system
  • Respiratory tract
  • Nervous system
  • Eye
  • Cardiovascular
Targets:
  • Kinases
  • GPCR
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E947-0493 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E947-0493?
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What is the minimum amount of E947-0493 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E947-0493
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E947-0493
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E947-0493 available by request