E973-0183 Screening compound: 2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-2-(4-methoxyphenyl)-1H-indene-1,3(2H)-dione

E973-0183 Screening compound: 2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-2-(4-methoxyphenyl)-1H-indene-1,3(2H)-dione
E973-0183 Screening compound: 2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-2-(4-methoxyphenyl)-1H-indene-1,3(2H)-dione alternative view

Chemical Structure Depiction of ChemDiv screening compound E973-0183
2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-2-(4-methoxyphenyl)-1H-indene-1,3(2H)-dione

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E973-0183

Molecular Formula

C23H23NO5 (C23 H23 NO5)

Compound Name

2-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-2-(4-methoxyphenyl)-1H-indene-1,3(2H)-dione

IUPAC name

2-{14-dioxa-8-azaspiro[4.5]decan-8-yl}-2-(4-methoxyphenyl)-23-dihydro-1H-indene-13-dione

SMILES

COc1ccc(C(C(c2c3cccc2)=O)(C3=O)N(CC2)CCC22OCCO2)cc1

InChI

InChI=1S/C23H23NO5/c1-27-17-8-6-16(7-9-17)23(20(25)18-4-2-3-5-19(18)21(23)26)24-12-10-22(11-13-24)28-14-15-29-22/h2-9H,10-15H2,1H3

InChI Key

RSQBZSSNWDOTMQ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD09696456

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

393.44

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.468

Distribution Coefficient, logD

3.468

Water Solubility, LogSw

-3.81

Polar Surface Area

50.534

Acid Dissociation Constant (pKa)

25.77

Base Dissociation Constant (pKb)

-0.66

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

39.13

E973-0183 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

GPCR Targeted Library (31838 compounds)

Neuropeptide S Library (2850 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Digestive system
  • Nervous system
Targets:
  • GPCR
  • GPCR
Mechanism of action:
  • Receptor's ligands
  • Receptor's ligands

References: we are preparing a list of scientific research reports with E973-0183 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E973-0183?
Check Price and Availability of E973-0183, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of E973-0183 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E973-0183
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E973-0183
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E973-0183 available by request