E977-0185 Screening compound: N-(2-CHLORO-4,6-DIMETHOXYPHENYL)-2-OXO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-7-SULFONAMIDE

E977-0185 Screening compound: N-(2-CHLORO-4,6-DIMETHOXYPHENYL)-2-OXO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-7-SULFONAMIDE
E977-0185 Screening compound: N-(2-CHLORO-4,6-DIMETHOXYPHENYL)-2-OXO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-7-SULFONAMIDE alternative view

Chemical Structure Depiction of ChemDiv screening compound E977-0185
N-(2-CHLORO-4,6-DIMETHOXYPHENYL)-2-OXO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-7-SULFONAMIDE

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

E977-0185

Molecular Formula

C18H19ClN2O5S (C18 H19 ClN2 O5 S)

Compound Name

N-(2-CHLORO-4,6-DIMETHOXYPHENYL)-2-OXO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-7-SULFONAMIDE

IUPAC name

N-(2-chloro-46-dimethoxyphenyl)-2-oxo-2345-tetrahydro-1H-1-benzazepine-7-sulfonamide

SMILES

COc(cc1OC)cc(Cl)c1NS(c(cc1)cc(CCC2)c1NC2=O)(=O)=O

InChI

InChI=1S/C18H19ClN2O5S/c1-25-12-9-14(19)18(16(10-12)26-2)21-27(23,24)13-6-7-15-11(8-13)4-3-5-17(22)20-15/h6-10,21H,3-5H2,1-2H3,(H,20,22)

InChI Key

GFVCHYGQCBFONA-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14934539

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

410.88

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

2.197

Distribution Coefficient, logD

0.803

Water Solubility, LogSw

-3.13

Polar Surface Area

79.818

Acid Dissociation Constant (pKa)

6.02

Base Dissociation Constant (pKb)

-2.93

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

27.80

E977-0185 in Drug Discovery

Included in Screening Libraries

Allosteric Kinases Inhibitors Library (23117 compounds)

Anti-Inflammatory Library (24602 compounds)

Anticancer Library (62698 compounds)

Protein-Protein Interaction Library (218420 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Female
  • Congenital
  • Skin
  • Immune system
  • Cancer
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with E977-0185 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound E977-0185?
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What is the minimum amount of E977-0185 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for E977-0185
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for E977-0185
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of E977-0185 available by request