F186-0427 Screening compound: N-(4-{[(5-chloro-2-methoxyphenyl)carbamoyl]methyl}-1,3-thiazol-2-yl)-4-methoxybenzamide
Chemical Structure Depiction of ChemDiv screening compound F186-0427
N-(4-{[(5-chloro-2-methoxyphenyl)carbamoyl]methyl}-1,3-thiazol-2-yl)-4-methoxybenzamide
Available from 1 mg
Formats:
- Glass Vials (4ml Glass Vials VWR #97047-678)
- 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)
Shiptime: 1 week worldwide delivery in most cases
Compound Identifiers
ChemDiv Compound ID
F186-0427
Molecular Formula
C20H18ClN3O4S (C20 H18 ClN3 O4 S)
Compound Name
N-(4-{[(5-chloro-2-methoxyphenyl)carbamoyl]methyl}-1,3-thiazol-2-yl)-4-methoxybenzamide
IUPAC name
N-(4-{[(5-chloro-2-methoxyphenyl)carbamoyl]methyl}-13-thiazol-2-yl)-4-methoxybenzamide
SMILES
COc(cc1)ccc1C(Nc1nc(CC(Nc(cc(cc2)Cl)c2OC)=O)cs1)=O
InChI Key
MDL Number (MFCD)
Chemical and Physical Properties
Saltdata
n/a
Molecular Weight
431.9
Hydrogen Bond Acceptors Count
7.00
Hydrogen Bond Donors Count
2.00
Rotatable Bond Count
9.00
Number of Nitrogen and Oxygen Atoms
7
Partition Coefficient, logP
3.975
Distribution Coefficient, logD
3.940
Water Solubility, LogSw
-4.53
Polar Surface Area
71.225
Acid Dissociation Constant (pKa)
8.48
Base Dissociation Constant (pKb)
0.07
Number of Chiral Centers
0.00
Percent sp3 carbon bonding
15.00
F186-0427 in Drug Discovery
Included in Screening Libraries
Allosteric Kinases Inhibitors Library (23117 compounds)
Anticancer Library (62698 compounds)
Protein-Protein Interaction Library (218420 compounds)
Adenosine Receptors Targeted Library (19896 compounds)
Chemokine Receptor-Targeted Library (18382 compounds)
Type II Kinase Inhibitors Library (6956 compounds)
Included in 1.7M Stock Database
- Cancer
- Female
- Congenital
- Skin
- Cancer
- Cancer
- Digestive system
- Respiratory tract
- Nervous system
- Eye
- Cardiovascular
- Immune system
- Digestive system
- Hemic and lymphatic
- Endocrine
- Kinases
- GPCR
- Kinases
- PPI modulators
- Receptor's ligands
- Receptor's ligands
References: we are preparing a list of scientific research reports with F186-0427 chemical compound. It will be published here after verification.
Frequently Asked Questions
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Available from 1 mg in Glass Vials or 96-tube racks.
ChemDiv sends parcels with Express services (UPS, WC).
- 1–2 days for small orders
- 2–4 weeks for large selections
- 0.5–50 mg of dry powder sample in single glass vials, custom vials
- DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)