F186-0753 Screening compound: N-[4-({[(2,6-difluorophenyl)methyl]carbamoyl}methyl)-1,3-thiazol-2-yl]-3,5-dimethoxybenzamide

F186-0753 Screening compound: N-[4-({[(2,6-difluorophenyl)methyl]carbamoyl}methyl)-1,3-thiazol-2-yl]-3,5-dimethoxybenzamide
F186-0753 Screening compound: N-[4-({[(2,6-difluorophenyl)methyl]carbamoyl}methyl)-1,3-thiazol-2-yl]-3,5-dimethoxybenzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound F186-0753
N-[4-({[(2,6-difluorophenyl)methyl]carbamoyl}methyl)-1,3-thiazol-2-yl]-3,5-dimethoxybenzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

F186-0753

Molecular Formula

C21H19F2N3O4S (C21 H19 F2 N3 O4 S)

Compound Name

N-[4-({[(2,6-difluorophenyl)methyl]carbamoyl}methyl)-1,3-thiazol-2-yl]-3,5-dimethoxybenzamide

IUPAC name

N-[4-({[(26-difluorophenyl)methyl]carbamoyl}methyl)-13-thiazol-2-yl]-35-dimethoxybenzamide

SMILES

COc1cc(C(Nc2nc(CC(NCc(c(F)ccc3)c3F)=O)cs2)=O)cc(OC)c1

InChI

InChI=1S/C21H19F2N3O4S/c1-29-14-6-12(7-15(9-14)30-2)20(28)26-21-25-13(11-31-21)8-19(27)24-10-16-17(22)4-3-5-18(16)23/h3-7,9,11H,8,10H2,1-2H3,(H,24,27)(H,25,26,28)

InChI Key

BCHSBCIRTZYCRK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD09240782

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

447.46

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

10.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.033

Distribution Coefficient, logD

4.028

Water Solubility, LogSw

-4.36

Polar Surface Area

73.159

Acid Dissociation Constant (pKa)

9.39

Base Dissociation Constant (pKb)

-1.30

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

19.00

F186-0753 in Drug Discovery

Included in Screening Libraries

Allosteric Kinases Inhibitors Library (23117 compounds)

Protein-Protein Interaction Library (218420 compounds)

Targeted Diversity Library (40567 compounds)

Chemokine Receptor-Targeted Library (18382 compounds)

Peptidomimetic Library (37031 compounds)

Type II Kinase Inhibitors Library (6956 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Female
  • Congenital
  • Skin
  • Immune system
  • Digestive system
  • Hemic and lymphatic
  • Endocrine
Targets:
  • Kinases
  • Kinases
Mechanism of action:
  • PPI modulators
  • Receptor's ligands
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with F186-0753 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound F186-0753?
Check Price and Availability of F186-0753, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of F186-0753 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for F186-0753
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for F186-0753
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of F186-0753 available by request