F389-0146 Screening compound: (2Z)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-2-[(4-chlorophenyl)methylidene]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide

F389-0146 Screening compound: (2Z)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-2-[(4-chlorophenyl)methylidene]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
F389-0146 Screening compound: (2Z)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-2-[(4-chlorophenyl)methylidene]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound F389-0146
(2Z)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-2-[(4-chlorophenyl)methylidene]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

F389-0146

Molecular Formula

C26H19Cl2N3O3 (C26 H19 Cl2 N3 O3)

Compound Name

(2Z)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-2-[(4-chlorophenyl)methylidene]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide

IUPAC name

(2Z)-N-[2-(5-chloro-1H-indol-3-yl)ethyl]-2-[(4-chlorophenyl)methylidene]-3-oxo-34-dihydro-2H-14-benzoxazine-6-carboxamide

SMILES

O=C(c(cc1)cc(NC2=O)c1O/C2=C\c(cc1)ccc1Cl)NCCc1c[nH]c(cc2)c1cc2Cl

InChI

InChI=1S/C26H19Cl2N3O3/c27-18-4-1-15(2-5-18)11-24-26(33)31-22-12-16(3-8-23(22)34-24)25(32)29-10-9-17-14-30-21-7-6-19(28)13-20(17)21/h1-8,11-14,30H,9-10H2,(H,29,32)(H,31,33)

InChI Key

IDOWUSDOCQFGCD-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14952876

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

492.36

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

3.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

5.563

Distribution Coefficient, logD

5.563

Water Solubility, LogSw

-6.24

Polar Surface Area

66.933

Acid Dissociation Constant (pKa)

11.97

Base Dissociation Constant (pKb)

-1.66

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

7.70

F389-0146 in Drug Discovery

Included in Screening Libraries

Aurora A-B Kinases Targeted Library (9426 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Male
  • Female
  • Hemic and lymphatic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with F389-0146 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound F389-0146?
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What is the minimum amount of F389-0146 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for F389-0146
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for F389-0146
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of F389-0146 available by request