F455-0665 Screening compound: 1-(4-fluorophenyl)-3-hydroxy-4-(4-methoxyphenyl)-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one

F455-0665 Screening compound: 1-(4-fluorophenyl)-3-hydroxy-4-(4-methoxyphenyl)-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one
F455-0665 Screening compound: 1-(4-fluorophenyl)-3-hydroxy-4-(4-methoxyphenyl)-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one alternative view

Chemical Structure Depiction of ChemDiv screening compound F455-0665
1-(4-fluorophenyl)-3-hydroxy-4-(4-methoxyphenyl)-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

F455-0665

Molecular Formula

C26H24FNO3 (C26 H24 FNO3)

Compound Name

1-(4-fluorophenyl)-3-hydroxy-4-(4-methoxyphenyl)-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one

IUPAC name

1-(4-fluorophenyl)-3-hydroxy-4-(4-methoxyphenyl)-5-[4-(propan-2-yl)phenyl]-25-dihydro-1H-pyrrol-2-one

SMILES

CC(C)c1ccc(C(C(c(cc2)ccc2OC)=C(C2=O)O)N2c(cc2)ccc2F)cc1

InChI

InChI=1S/C26H24FNO3/c1-16(2)17-4-6-19(7-5-17)24-23(18-8-14-22(31-3)15-9-18)25(29)26(30)28(24)21-12-10-20(27)11-13-21/h4-16,24,29H,1-3H3/t24-/m1/s1

InChI Key

ZWNDBPSKNFXGGG-XMMPIXPASA-N

MDL Number (MFCD)

MFCD27130539

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

417.48

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

5.645

Distribution Coefficient, logD

5.645

Water Solubility, LogSw

-5.58

Polar Surface Area

38.021

Acid Dissociation Constant (pKa)

10.72

Base Dissociation Constant (pKb)

-4.42

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

19.20

F455-0665 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Cysteine Proteases Inhibitors Library (7839 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Nervous system
  • Cardiovascular
  • Skin
  • Metabolic
  • Endocrine
  • Immune system
  • Cancer
Targets:
  • Proteases
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with F455-0665 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound F455-0665?
Check Price and Availability of F455-0665, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of F455-0665 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for F455-0665
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for F455-0665
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of F455-0665 available by request