F489-0273 Screening compound: N-[2-(4-chlorophenyl)ethyl]-4-[4-(4-methoxyphenyl)-3-methyl-7-oxo-6H,7H-[1,2]oxazolo[3,4-d]pyridazin-6-yl]butanamide

F489-0273 Screening compound: N-[2-(4-chlorophenyl)ethyl]-4-[4-(4-methoxyphenyl)-3-methyl-7-oxo-6H,7H-[1,2]oxazolo[3,4-d]pyridazin-6-yl]butanamide
F489-0273 Screening compound: N-[2-(4-chlorophenyl)ethyl]-4-[4-(4-methoxyphenyl)-3-methyl-7-oxo-6H,7H-[1,2]oxazolo[3,4-d]pyridazin-6-yl]butanamide alternative view

Chemical Structure Depiction of ChemDiv screening compound F489-0273
N-[2-(4-chlorophenyl)ethyl]-4-[4-(4-methoxyphenyl)-3-methyl-7-oxo-6H,7H-[1,2]oxazolo[3,4-d]pyridazin-6-yl]butanamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

F489-0273

Molecular Formula

C25H25ClN4O4 (C25 H25 ClN4 O4)

Compound Name

N-[2-(4-chlorophenyl)ethyl]-4-[4-(4-methoxyphenyl)-3-methyl-7-oxo-6H,7H-[1,2]oxazolo[3,4-d]pyridazin-6-yl]butanamide

IUPAC name

N-[2-(4-chlorophenyl)ethyl]-4-[4-(4-methoxyphenyl)-3-methyl-7-oxo-6H7H-[12]oxazolo[34-d]pyridazin-6-yl]butanamide

SMILES

Cc(onc12)c2C(c(cc2)ccc2OC)=NN(CCCC(NCCc(cc2)ccc2Cl)=O)C1=O

InChI

InChI=1S/C25H25ClN4O4/c1-16-22-23(18-7-11-20(33-2)12-8-18)28-30(25(32)24(22)29-34-16)15-3-4-21(31)27-14-13-17-5-9-19(26)10-6-17/h5-12H,3-4,13-15H2,1-2H3,(H,27,31)

InChI Key

LFLPOQAISAQKHF-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27134299

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

480.95

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

10.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

2.512

Distribution Coefficient, logD

2.509

Water Solubility, LogSw

-3.68

Polar Surface Area

81.353

Acid Dissociation Constant (pKa)

14.38

Base Dissociation Constant (pKb)

5.27

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

28.00

F489-0273 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Targeted Diversity Library (40567 compounds)

Adenosine Receptors Targeted Library (19896 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Digestive system
  • Respiratory tract
  • Nervous system
  • Eye
  • Cardiovascular
Targets:
  • Kinases
  • GPCR
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with F489-0273 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound F489-0273?
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What is the minimum amount of F489-0273 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for F489-0273
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for F489-0273
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of F489-0273 available by request