G274-0125 Screening compound: 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidin-1-yl]-6-(thiophen-2-yl)pyridazine

G274-0125 Screening compound: 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidin-1-yl]-6-(thiophen-2-yl)pyridazine
G274-0125 Screening compound: 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidin-1-yl]-6-(thiophen-2-yl)pyridazine alternative view

Chemical Structure Depiction of ChemDiv screening compound G274-0125
3-[4-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidin-1-yl]-6-(thiophen-2-yl)pyridazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G274-0125

Molecular Formula

C25H26N4OS (C25 H26 N4 OS)

Compound Name

3-[4-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidin-1-yl]-6-(thiophen-2-yl)pyridazine

IUPAC name

3-[4-(4-phenyl-1236-tetrahydropyridine-1-carbonyl)piperidin-1-yl]-6-(thiophen-2-yl)pyridazine

SMILES

O=C(C(CC1)CCN1c(cc1)nnc1-c1cccs1)N(CC1)CC=C1c1ccccc1

InChI

InChI=1S/C25H26N4OS/c30-25(29-16-10-20(11-17-29)19-5-2-1-3-6-19)21-12-14-28(15-13-21)24-9-8-22(26-27-24)23-7-4-18-31-23/h1-10,18,21H,11-17H2

InChI Key

GIZUUIMJILMBOE-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14992807

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

430.57

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

4.728

Distribution Coefficient, logD

4.728

Water Solubility, LogSw

-4.71

Polar Surface Area

42.021

Acid Dissociation Constant (pKa)

22.38

Base Dissociation Constant (pKb)

3.44

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

32.00

G274-0125 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

GPCR Targeted Library (31838 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
Targets:
  • GPCR
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with G274-0125 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G274-0125?
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What is the minimum amount of G274-0125 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G274-0125
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G274-0125
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G274-0125 available by request