G274-0192 Screening compound: N-[2-(4-sulfamoylphenyl)ethyl]-1-[6-(thiophen-2-yl)pyridazin-3-yl]piperidine-4-carboxamide

G274-0192 Screening compound: N-[2-(4-sulfamoylphenyl)ethyl]-1-[6-(thiophen-2-yl)pyridazin-3-yl]piperidine-4-carboxamide
G274-0192 Screening compound: N-[2-(4-sulfamoylphenyl)ethyl]-1-[6-(thiophen-2-yl)pyridazin-3-yl]piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G274-0192
N-[2-(4-sulfamoylphenyl)ethyl]-1-[6-(thiophen-2-yl)pyridazin-3-yl]piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G274-0192

Molecular Formula

C22H25N5O3S2 (C22 H25 N5 O3 S2)

Compound Name

N-[2-(4-sulfamoylphenyl)ethyl]-1-[6-(thiophen-2-yl)pyridazin-3-yl]piperidine-4-carboxamide

IUPAC name

N-[2-(4-sulfamoylphenyl)ethyl]-1-[6-(thiophen-2-yl)pyridazin-3-yl]piperidine-4-carboxamide

SMILES

NS(c1ccc(CCNC(C(CC2)CCN2c(cc2)nnc2-c2cccs2)=O)cc1)(=O)=O

InChI

InChI=1S/C22H25N5O3S2/c23-32(29,30)18-5-3-16(4-6-18)9-12-24-22(28)17-10-13-27(14-11-17)21-8-7-19(25-26-21)20-2-1-15-31-20/h1-8,15,17H,9-14H2,(H,24,28)(H2,23,29,30)

InChI Key

LPGPBRVFXMNJCT-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14992851

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

471.6

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

3.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

1.832

Distribution Coefficient, logD

1.832

Water Solubility, LogSw

-2.32

Polar Surface Area

100.502

Acid Dissociation Constant (pKa)

10.18

Base Dissociation Constant (pKb)

3.44

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

31.80

G274-0192 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Protein-Protein Interaction Library (218420 compounds)

Antibacterial Compounds Library (13827 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Hemic and lymphatic
  • Cardiovascular
  • Infections
  • Immune system
  • animal
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with G274-0192 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G274-0192?
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What is the minimum amount of G274-0192 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G274-0192
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G274-0192
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G274-0192 available by request