G281-2436 Screening compound: 4-(4-chlorophenyl)-9-methyl-N~5~-(3-methylphenyl)-7,8,9,10-tetrahydro-4H-pyrido[4',3':4,5]thieno[3,2-f]pyrrolo[1,2-a][1,4]diazepine-5(6H)-carboxamide

G281-2436 Screening compound: 4-(4-chlorophenyl)-9-methyl-N~5~-(3-methylphenyl)-7,8,9,10-tetrahydro-4H-pyrido[4',3':4,5]thieno[3,2-f]pyrrolo[1,2-a][1,4]diazepine-5(6H)-carboxamide
G281-2436 Screening compound: 4-(4-chlorophenyl)-9-methyl-N~5~-(3-methylphenyl)-7,8,9,10-tetrahydro-4H-pyrido[4',3':4,5]thieno[3,2-f]pyrrolo[1,2-a][1,4]diazepine-5(6H)-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G281-2436
4-(4-chlorophenyl)-9-methyl-N~5~-(3-methylphenyl)-7,8,9,10-tetrahydro-4H-pyrido[4',3':4,5]thieno[3,2-f]pyrrolo[1,2-a][1,4]diazepine-5(6H)-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G281-2436

Molecular Formula

C28H27ClN4OS (C28 H27 ClN4 OS)

Compound Name

4-(4-chlorophenyl)-9-methyl-N~5~-(3-methylphenyl)-7,8,9,10-tetrahydro-4H-pyrido[4',3':4,5]thieno[3,2-f]pyrrolo[1,2-a][1,4]diazepine-5(6H)-carboxamide

IUPAC name

7-(4-chlorophenyl)-14-methyl-N-(3-methylphenyl)-17-thia-2814-triazatetracyclo[8.7.0.0^{26}.0^{1116}]heptadeca-1(10)3511(16)-tetraene-8-carboxamide

SMILES

Cc1cccc(NC(N(Cc2c(-n3c4ccc3)sc3c2CCN(C)C3)C4c(cc2)ccc2Cl)=O)c1

InChI

InChI=1S/C28H27ClN4OS/c1-18-5-3-6-21(15-18)30-28(34)33-16-23-22-12-14-31(2)17-25(22)35-27(23)32-13-4-7-24(32)26(33)19-8-10-20(29)11-9-19/h3-11,13,15,26H,12,14,16-17H2,1-2H3,(H,30,34)/t26-/m1/s1

InChI Key

PPGLHCXLAOPWOS-AREMUKBSSA-N

MDL Number (MFCD)

MFCD27212670

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

503.07

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

6.468

Distribution Coefficient, logD

4.704

Water Solubility, LogSw

-6.38

Polar Surface Area

30.353

Acid Dissociation Constant (pKa)

14.96

Base Dissociation Constant (pKb)

9.16

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

25.00

G281-2436 in Drug Discovery

Included in Screening Libraries

Protein-Protein Interaction Library (218420 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with G281-2436 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G281-2436?
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What is the minimum amount of G281-2436 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G281-2436
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G281-2436
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G281-2436 available by request