G282-6948 Screening compound: 7-cyclopropyl-N1-(2,5-difluorophenyl)-N6-[(4-fluorophenyl)methyl]-6-methyl-8-oxo-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1,6-dicarboxamide

G282-6948 Screening compound: 7-cyclopropyl-N1-(2,5-difluorophenyl)-N6-[(4-fluorophenyl)methyl]-6-methyl-8-oxo-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1,6-dicarboxamide
G282-6948 Screening compound: 7-cyclopropyl-N1-(2,5-difluorophenyl)-N6-[(4-fluorophenyl)methyl]-6-methyl-8-oxo-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1,6-dicarboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G282-6948
7-cyclopropyl-N1-(2,5-difluorophenyl)-N6-[(4-fluorophenyl)methyl]-6-methyl-8-oxo-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1,6-dicarboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G282-6948

Molecular Formula

C25H22F3N5O3 (C25 H22 F3 N5 O3)

Compound Name

7-cyclopropyl-N1-(2,5-difluorophenyl)-N6-[(4-fluorophenyl)methyl]-6-methyl-8-oxo-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1,6-dicarboxamide

IUPAC name

7-cyclopropyl-N1-(25-difluorophenyl)-N6-[(4-fluorophenyl)methyl]-6-methyl-8-oxo-5H6H7H8H-imidazo[15-a]pyrazine-16-dicarboxamide

SMILES

CC(Cn1c2c(C(Nc(cc(cc3)F)c3F)=O)nc1)(C(NCc(cc1)ccc1F)=O)N(C1CC1)C2=O

InChI

InChI=1S/C25H22F3N5O3/c1-25(24(36)29-11-14-2-4-15(26)5-3-14)12-32-13-30-20(21(32)23(35)33(25)17-7-8-17)22(34)31-19-10-16(27)6-9-18(19)28/h2-6,9-10,13,17H,7-8,11-12H2,1H3,(H,29,36)(H,31,34)/t25-/m0/s1

InChI Key

ADGGZYGTFDEFQL-VWLOTQADSA-N

MDL Number (MFCD)

MFCD27213135

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

497.48

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

2.878

Distribution Coefficient, logD

2.858

Water Solubility, LogSw

-3.19

Polar Surface Area

73.631

Acid Dissociation Constant (pKa)

8.73

Base Dissociation Constant (pKb)

0.39

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

28.00

G282-6948 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

Cyclic Ugi PPI Library (9586 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Protein-Protein Interaction Library (218420 compounds)

Peptidomimetic Library (37031 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds
  • Mimetics
  • Mimetics
  • Mimetics

References: we are preparing a list of scientific research reports with G282-6948 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G282-6948?
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What is the minimum amount of G282-6948 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G282-6948
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G282-6948
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G282-6948 available by request