G282-8199 Screening compound: 7-cyclopropyl-N1-(2,4-dimethylphenyl)-N6-[(2-methoxyphenyl)methyl]-6-methyl-8-oxo-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1,6-dicarboxamide

G282-8199 Screening compound: 7-cyclopropyl-N1-(2,4-dimethylphenyl)-N6-[(2-methoxyphenyl)methyl]-6-methyl-8-oxo-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1,6-dicarboxamide
G282-8199 Screening compound: 7-cyclopropyl-N1-(2,4-dimethylphenyl)-N6-[(2-methoxyphenyl)methyl]-6-methyl-8-oxo-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1,6-dicarboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G282-8199
7-cyclopropyl-N1-(2,4-dimethylphenyl)-N6-[(2-methoxyphenyl)methyl]-6-methyl-8-oxo-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1,6-dicarboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G282-8199

Molecular Formula

C28H31N5O4 (C28 H31 N5 O4)

Compound Name

7-cyclopropyl-N1-(2,4-dimethylphenyl)-N6-[(2-methoxyphenyl)methyl]-6-methyl-8-oxo-5H,6H,7H,8H-imidazo[1,5-a]pyrazine-1,6-dicarboxamide

IUPAC name

7-cyclopropyl-N1-(24-dimethylphenyl)-N6-[(2-methoxyphenyl)methyl]-6-methyl-8-oxo-5H6H7H8H-imidazo[15-a]pyrazine-16-dicarboxamide

SMILES

CC(Cn1c2c(C(Nc3c(C)cc(C)cc3)=O)nc1)(C(NCc(cccc1)c1OC)=O)N(C1CC1)C2=O

InChI

InChI=1S/C28H31N5O4/c1-17-9-12-21(18(2)13-17)31-25(34)23-24-26(35)33(20-10-11-20)28(3,15-32(24)16-30-23)27(36)29-14-19-7-5-6-8-22(19)37-4/h5-9,12-13,16,20H,10-11,14-15H2,1-4H3,(H,29,36)(H,31,34)/t28-/m0/s1

InChI Key

PNYGERMWIKJUCO-NDEPHWFRSA-N

MDL Number (MFCD)

MFCD27213310

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

501.59

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

3.386

Distribution Coefficient, logD

3.386

Water Solubility, LogSw

-3.56

Polar Surface Area

81.261

Acid Dissociation Constant (pKa)

12.14

Base Dissociation Constant (pKb)

1.66

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

35.70

G282-8199 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Cyclic Ugi PPI Library (9586 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

Protein-Protein Interaction Library (218420 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds
  • Mimetics

References: we are preparing a list of scientific research reports with G282-8199 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G282-8199?
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What is the minimum amount of G282-8199 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G282-8199
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G282-8199
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G282-8199 available by request