G283-0320 Screening compound: N~1~-(2,4-difluorophenyl)-2-{[5-(4-fluorophenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}acetamide

G283-0320 Screening compound: N~1~-(2,4-difluorophenyl)-2-{[5-(4-fluorophenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}acetamide
G283-0320 Screening compound: N~1~-(2,4-difluorophenyl)-2-{[5-(4-fluorophenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G283-0320
N~1~-(2,4-difluorophenyl)-2-{[5-(4-fluorophenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G283-0320

Molecular Formula

C18H14F3N3O3S (C18 H14 F3 N3 O3 S)

Compound Name

N~1~-(2,4-difluorophenyl)-2-{[5-(4-fluorophenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}acetamide

IUPAC name

N-(24-difluorophenyl)-2-{[5-(4-fluorophenyl)-4-methyl-11-dioxo-1lambda62-thiazol-3-yl]amino}acetamide

SMILES

CC(C(NCC(Nc(ccc(F)c1)c1F)=O)=N1)=C(c(cc2)ccc2F)S1(=O)=O

InChI

InChI=1S/C18H14F3N3O3S/c1-10-17(11-2-4-12(19)5-3-11)28(26,27)24-18(10)22-9-16(25)23-15-7-6-13(20)8-14(15)21/h2-8H,9H2,1H3,(H,22,24)(H,23,25)

InChI Key

JOIFGUSMBGSYQK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14994480

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

409.39

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

2.785

Distribution Coefficient, logD

2.779

Water Solubility, LogSw

-3.39

Polar Surface Area

74.618

Acid Dissociation Constant (pKa)

9.25

Base Dissociation Constant (pKb)

-3.05

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

11.10

G283-0320 in Drug Discovery

Included in Screening Libraries

Protein Arginine Methyltransferases Library (27925 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with G283-0320 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G283-0320?
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What is the minimum amount of G283-0320 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G283-0320
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G283-0320
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G283-0320 available by request