G283-1751 Screening compound: 2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-(4-fluoro-2-methylphenyl)acetamide

G283-1751 Screening compound: 2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-(4-fluoro-2-methylphenyl)acetamide
G283-1751 Screening compound: 2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-(4-fluoro-2-methylphenyl)acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G283-1751
2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-(4-fluoro-2-methylphenyl)acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G283-1751

Molecular Formula

C21H22FN3O3S (C21 H22 FN3 O3 S)

Compound Name

2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-(4-fluoro-2-methylphenyl)acetamide

IUPAC name

2-{[5-(34-dimethylphenyl)-4-methyl-11-dioxo-1lambda62-thiazol-3-yl]amino}-N-(4-fluoro-2-methylphenyl)acetamide

SMILES

CC(C(NCC(Nc(cc1)c(C)cc1F)=O)=N1)=C(c2cc(C)c(C)cc2)S1(=O)=O

InChI

InChI=1S/C21H22FN3O3S/c1-12-5-6-16(9-13(12)2)20-15(4)21(25-29(20,27)28)23-11-19(26)24-18-8-7-17(22)10-14(18)3/h5-10H,11H2,1-4H3,(H,23,25)(H,24,26)

InChI Key

SWGBHHGPVRCLKM-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14994597

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

415.49

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.780

Distribution Coefficient, logD

3.780

Water Solubility, LogSw

-3.92

Polar Surface Area

74.618

Acid Dissociation Constant (pKa)

10.89

Base Dissociation Constant (pKb)

-1.73

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

23.80

G283-1751 in Drug Discovery

Included in Screening Libraries

Protein Arginine Methyltransferases Library (27925 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with G283-1751 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G283-1751?
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What is the minimum amount of G283-1751 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G283-1751
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G283-1751
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G283-1751 available by request