G283-1820 Screening compound: 2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-(3-ethoxy-4-methoxybenzyl)acetamide

G283-1820 Screening compound: 2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-(3-ethoxy-4-methoxybenzyl)acetamide
G283-1820 Screening compound: 2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-(3-ethoxy-4-methoxybenzyl)acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound G283-1820
2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-(3-ethoxy-4-methoxybenzyl)acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

G283-1820

Molecular Formula

C24H29N3O5S (C24 H29 N3 O5 S)

Compound Name

2-{[5-(3,4-dimethylphenyl)-4-methyl-1,1-dioxo-1H-1lambda~6~-isothiazol-3-yl]amino}-N~1~-(3-ethoxy-4-methoxybenzyl)acetamide

IUPAC name

2-{[5-(34-dimethylphenyl)-4-methyl-11-dioxo-1lambda62-thiazol-3-yl]amino}-N-[(3-ethoxy-4-methoxyphenyl)methyl]acetamide

SMILES

CCOc(cc(CNC(CNC(C(C)=C1c2cc(C)c(C)cc2)=NS1(=O)=O)=O)cc1)c1OC

InChI

InChI=1S/C24H29N3O5S/c1-6-32-21-12-18(8-10-20(21)31-5)13-25-22(28)14-26-24-17(4)23(33(29,30)27-24)19-9-7-15(2)16(3)11-19/h7-12H,6,13-14H2,1-5H3,(H,25,28)(H,26,27)

InChI Key

JTERLSCIWQEJLL-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD14994600

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

471.58

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

10.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.343

Distribution Coefficient, logD

3.343

Water Solubility, LogSw

-3.60

Polar Surface Area

91.479

Acid Dissociation Constant (pKa)

12.00

Base Dissociation Constant (pKb)

-2.20

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

33.30

G283-1820 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Arginine Methyltransferases Library (27925 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with G283-1820 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound G283-1820?
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What is the minimum amount of G283-1820 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for G283-1820
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for G283-1820
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of G283-1820 available by request